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Aliases for CBWD1 Gene

Aliases for CBWD1 Gene

  • COBW Domain Containing 1 2 3 5
  • Cobalamin Synthase W Domain-Containing Protein 1 3 4
  • NPC-A-6 COBW Domain-Containing Protein 1 3 4
  • COBP 3 4
  • Cobalamin Synthetase W Domain-Containing Protein 1 3
  • COBW-Like Protein 3
  • NPC-A-6 4

External Ids for CBWD1 Gene

Previous GeneCards Identifiers for CBWD1 Gene

  • GC00U991133
  • GC09M000111

Summaries for CBWD1 Gene

GeneCards Summary for CBWD1 Gene

CBWD1 (COBW Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is CBWD3.

Gene Wiki entry for CBWD1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBWD1 Gene

Genomics for CBWD1 Gene

Regulatory Elements for CBWD1 Gene

Enhancers for CBWD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CBWD1 on UCSC Golden Path with GeneCards custom track

Promoters for CBWD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CBWD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CBWD1 Gene

121,038 bp from pter
179,147 bp from pter
58,110 bases
Minus strand

Genomic View for CBWD1 Gene

Genes around CBWD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBWD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBWD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBWD1 Gene

Proteins for CBWD1 Gene

  • Protein details for CBWD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COBW domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A2RU55
    • A8K3N3
    • B0AZR4
    • Q49AJ1
    • Q5VVK2
    • Q6VBU6
    • Q7Z5Z0
    • Q7Z652
    • Q9BY38
    • Q9NYD0

    Protein attributes for CBWD1 Gene

    395 amino acids
    Molecular mass:
    44068 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CBWD1 Gene


neXtProt entry for CBWD1 Gene

Proteomics data for CBWD1 Gene at MOPED

Post-translational modifications for CBWD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CBWD1 Gene

Domains & Families for CBWD1 Gene

Suggested Antigen Peptide Sequences for CBWD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 cobW C-terminal domain.
  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
  • Contains 1 cobW C-terminal domain.
  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
genes like me logo Genes that share domains with CBWD1: view

No data available for Gene Families for CBWD1 Gene

Function for CBWD1 Gene

Molecular function for CBWD1 Gene

UniProtKB/Swiss-Prot Induction:
Increased expression in response to dopamine treatment. Down-regulated by ZNF658 in response to zinc.

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBWD1 Gene

Localization for CBWD1 Gene

Subcellular locations from

Jensen Localization Image for CBWD1 Gene COMPARTMENTS Subcellular localization image for CBWD1 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CBWD1 Gene

Pathways & Interactions for CBWD1 Gene

SuperPathways for CBWD1 Gene

No Data Available

Interacting Proteins for CBWD1 Gene

Gene Ontology (GO) - Biological Process for CBWD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CBWD1 Gene

Drugs & Compounds for CBWD1 Gene

No Compound Related Data Available

Transcripts for CBWD1 Gene

Unigene Clusters for CBWD1 Gene

COBW domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CBWD1 Gene

No ASD Table

Relevant External Links for CBWD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CBWD1 Gene

mRNA expression in normal human tissues for CBWD1 Gene

Protein differential expression in normal tissues from HIPED for CBWD1 Gene

This gene is overexpressed in Pancreas (33.8), Bone (25.4), and Peripheral blood mononuclear cells (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CBWD1 Gene

SOURCE GeneReport for Unigene cluster for CBWD1 Gene Hs.531330

mRNA Expression by UniProt/SwissProt for CBWD1 Gene

Tissue specificity: Ubiquitously expressed. Up-regulated in cultured astrocytes treated with dopamine.
genes like me logo Genes that share expression patterns with CBWD1: view

Protein tissue co-expression partners for CBWD1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CBWD1 Gene

Orthologs for CBWD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CBWD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CBWD2 35
  • 90.02 (n)
  • 88.83 (a)
-- 36
  • 88 (a)
(Canis familiaris)
Mammalia CBWD2 35
  • 90.1 (n)
  • 89.59 (a)
-- 36
  • 89 (a)
(Mus musculus)
Mammalia Cbwd1 35
  • 84.7 (n)
  • 81.79 (a)
Cbwd1 16
Cbwd1 36
  • 81 (a)
(Pan troglodytes)
Mammalia CBWD2 35
  • 99.16 (n)
  • 98.99 (a)
-- 36
  • 98 (a)
-- 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Cbwd1 35
  • 82.44 (n)
  • 80.05 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
(Gallus gallus)
Aves CBWD1 35
  • 74.07 (n)
  • 78.06 (a)
CBWD1 36
  • 73 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cbwd2 35
  • 71.87 (n)
  • 74.72 (a)
(Danio rerio)
Actinopterygii cbwd 35
  • 68.93 (n)
  • 74.29 (a)
cbwd 36
  • 72 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8293 35
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR044W 35
  • 49.85 (n)
  • 44.04 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C08613g 35
  • 54.8 (n)
  • 46.75 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNR029C 35
  • 52.68 (n)
  • 44.07 (a)
-- 36
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G26520 35
  • 53.4 (n)
  • 42.01 (a)
(Hordeum vulgare)
Liliopsida Hv.9552 35
(Oryza sativa)
Liliopsida Os.47385 35
Os07g0598900 35
  • 51.11 (n)
  • 41.45 (a)
(Triticum aestivum)
Liliopsida Ta.20404 35
(Zea mays)
Liliopsida Zm.3533 35
bread mold
(Neurospora crassa)
Ascomycetes NCU11371 35
  • 50.66 (n)
  • 46.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC15D4.05 35
  • 52.38 (n)
  • 44.44 (a)
Species with no ortholog for CBWD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for CBWD1 Gene

Gene Tree for CBWD1 (if available)
Gene Tree for CBWD1 (if available)

Paralogs for CBWD1 Gene

Paralogs for CBWD1 Gene

(5) SIMAP similar genes for CBWD1 Gene using alignment to 4 proteins: Pseudogenes for CBWD1 Gene

genes like me logo Genes that share paralogs with CBWD1: view

Variants for CBWD1 Gene

Sequence variations from dbSNP and Humsavar for CBWD1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_026979 -
rs701800 -- 121,495(-) AACAC(A/G)TTTCC reference, missense, utr-variant-3-prime
rs7470333 -- 168,197(+) gaaga(A/T)gtagc intron-variant, upstream-variant-2KB
rs7848153 -- 162,534(+) AACCA(G/T)ACTTC intron-variant
rs7854164 -- 141,523(+) cccta(A/C)aagag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CBWD1 Gene

Variant ID Type Subtype PubMed ID
nsv891939 CNV Loss 21882294
dgv2266e1 CNV Complex 17122850
esv735 CNV CNV 17122850
dgv253e55 CNV Gain 17911159
dgv254e55 CNV Gain 17911159
nsv891940 CNV Gain 21882294
nsv515505 CNV Gain+Loss 19592680
esv27644 CNV Gain 19812545
nsv8403 CNV Gain+Loss 18304495
dgv7989n71 CNV Loss 21882294
nsv891942 CNV Gain 21882294
nsv891943 CNV Gain 21882294
nsv471465 CNV Duplication 19718026
esv2674955 CNV Deletion 23128226
essv1889 CNV CNV 17122850
dgv2267e1 CNV Complex 17122850
esv2668459 CNV Deletion 23128226
nsv442127 CNV CNV 18776908
dgv7990n71 CNV Gain 21882294
dgv7991n71 CNV Gain 21882294

Variation tolerance for CBWD1 Gene

Gene Damage Index Score: 3.27; 52.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CBWD1 Gene

Disorders for CBWD1 Gene

Relevant External Links for CBWD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CBWD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBWD1 Gene

Publications for CBWD1 Gene

  1. Diverse fates of paralogs following segmental duplication of telomeric genes. (PMID: 15233989) Wong A. … Ledbetter D.H. (Genomics 2004) 2 3 4 67
  2. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PMID: 12421752) Fan Y. … Trask B.J. (Genome Res. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3

Products for CBWD1 Gene

Sources for CBWD1 Gene