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Aliases for CBWD1 Gene

Aliases for CBWD1 Gene

  • COBW Domain Containing 1 2 3
  • Cobalamin Synthase W Domain-Containing Protein 1 3 4
  • NPC-A-6 COBW Domain-Containing Protein 1 3 4
  • COBP 3 4
  • Cobalamin Synthetase W Domain-Containing Protein 1 3
  • COBW Domain-Containing Protein 1 3
  • COBW-Like Protein 3
  • NPC-A-6 4

External Ids for CBWD1 Gene

Summaries for CBWD1 Gene

GeneCards Summary for CBWD1 Gene

CBWD1 (COBW Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is CBWD3.

Gene Wiki entry for CBWD1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBWD1 Gene

Genomics for CBWD1 Gene

Genomic Location for CBWD1 Gene

Start:
121,038 bp from pter
End:
179,147 bp from pter
Size:
58,110 bases
Orientation:
Minus strand

Genomic View for CBWD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CBWD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBWD1 Gene

Regulatory Elements for CBWD1 Gene

Proteins for CBWD1 Gene

  • Protein details for CBWD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRT8-CBWD1_HUMAN
    Recommended name:
    COBW domain-containing protein 1
    Protein Accession:
    Q9BRT8
    Secondary Accessions:
    • A2RU55
    • A8K3N3
    • B0AZR4
    • Q49AJ1
    • Q5VVK2
    • Q6VBU6
    • Q7Z5Z0
    • Q7Z652
    • Q9BY38
    • Q9NYD0

    Protein attributes for CBWD1 Gene

    Size:
    395 amino acids
    Molecular mass:
    44068 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CBWD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CBWD1 Gene

Proteomics data for CBWD1 Gene at MOPED

Post-translational modifications for CBWD1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys55, Lys69, Lys176, Lys306, and Lys370

No data available for DME Specific Peptides for CBWD1 Gene

Domains for CBWD1 Gene

UniProtKB/Swiss-Prot:

CBWD1_HUMAN
Domain:
  • Contains 1 cobW C-terminal domain.:
    • Q9BRT8
Family:
  • Belongs to the CobW family.:
    • Q9BRT8
genes like me logo Genes that share domains with CBWD1: view

No data available for Gene Families for CBWD1 Gene

Function for CBWD1 Gene

Molecular function for CBWD1 Gene

UniProtKB/Swiss-Prot Induction: Increased expression in response to dopamine treatment.

Gene Ontology (GO) - Molecular Function for CBWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CBWD1: view

miRNA for CBWD1 Gene

miRTarBase miRNAs that target CBWD1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CBWD1 Gene

Localization for CBWD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBWD1 Gene COMPARTMENTS Subcellular localization image for CBWD1 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CBWD1 Gene

Pathways for CBWD1 Gene

SuperPathways for CBWD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CBWD1 Gene

None

No data available for Pathways by source for CBWD1 Gene

Transcripts for CBWD1 Gene

Unigene Clusters for CBWD1 Gene

COBW domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CBWD1 Gene

No ASD Table

Relevant External Links for CBWD1 Gene

GeneLoc Exon Structure for
CBWD1
ECgene alternative splicing isoforms for
CBWD1

Expression for CBWD1 Gene

mRNA expression in normal human tissues for CBWD1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CBWD1 Gene

SOURCE GeneReport for Unigene cluster for CBWD1 Gene Hs.531330

mRNA Expression by UniProt/SwissProt for CBWD1 Gene

Q9BRT8-CBWD1_HUMAN
Tissue specificity: Ubiquitously expressed. Up-regulated in cultured astrocytes treated with dopamine.
genes like me logo Genes that share expressions with CBWD1: view

Orthologs for CBWD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CBWD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 98 (a)
ManyToMany
-- 37
  • 96 (a)
ManyToMany
CBWD2 36
  • 99.16 (n)
  • 98.99 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 88 (a)
OneToMany
CBWD2 36
  • 90.02 (n)
  • 88.83 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 89 (a)
OneToMany
CBWD2 36
  • 90.1 (n)
  • 89.59 (a)
mouse
(Mus musculus)
Mammalia Cbwd1 36
  • 84.7 (n)
  • 81.79 (a)
Cbwd1 16
Cbwd1 37
  • 81 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cbwd1 36
  • 82.44 (n)
  • 80.05 (a)
chicken
(Gallus gallus)
Aves CBWD1 36
  • 74.07 (n)
  • 78.06 (a)
CBWD1 37
  • 73 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cbwd2 36
  • 71.87 (n)
  • 74.72 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8293 36
zebrafish
(Danio rerio)
Actinopterygii cbwd 36
  • 68.93 (n)
  • 74.29 (a)
cbwd 37
  • 72 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR044W 36
  • 49.85 (n)
  • 44.04 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 32 (a)
OneToMany
YNR029C 36
  • 52.68 (n)
  • 44.07 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C08613g 36
  • 54.8 (n)
  • 46.75 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G26520 36
  • 53.4 (n)
  • 42.01 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.9552 36
corn
(Zea mays)
Liliopsida Zm.3533 36
rice
(Oryza sativa)
Liliopsida Os.47385 36
Os07g0598900 36
  • 51.11 (n)
  • 41.45 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.20404 36
bread mold
(Neurospora crassa)
Ascomycetes NCU11371 36
  • 50.66 (n)
  • 46.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC15D4.05 36
  • 52.38 (n)
  • 44.44 (a)
Species with no ortholog for CBWD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for CBWD1 Gene

ENSEMBL:
Gene Tree for CBWD1 (if available)
TreeFam:
Gene Tree for CBWD1 (if available)

Paralogs for CBWD1 Gene

Paralogs for CBWD1 Gene

Selected SIMAP similar genes for CBWD1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CBWD1 Gene

genes like me logo Genes that share paralogs with CBWD1: view

Variants for CBWD1 Gene

Sequence variations from dbSNP and Humsavar for CBWD1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs12380 -- 172,167(-) GGACA(A/G)TGGCC missense, reference, nc-transcript-variant
rs14412 -- 162,456(-) ACTAT(A/T)GTGGA synonymous-codon, reference, nc-transcript-variant
rs1756536 -- 136,656(+) TAAAA(C/T)TTCAA intron-variant
rs1757287 -- 168,121(-) gatgg(A/C)ttctt intron-variant
rs2152658 -- 140,020(+) cccac(A/G)gagtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CBWD1 Gene

Variant ID Type Subtype PubMed ID
nsv891939 CNV Loss 21882294
dgv2266e1 CNV Complex 17122850
esv735 CNV CNV 17122850
dgv253e55 CNV Gain 17911159
dgv254e55 CNV Gain 17911159
nsv891940 CNV Gain 21882294
nsv515505 CNV Gain+Loss 19592680
esv27644 CNV Gain 19812545
nsv8403 CNV Gain+Loss 18304495
dgv7989n71 CNV Loss 21882294
nsv891942 CNV Gain 21882294
nsv891943 CNV Gain 21882294
nsv471465 CNV Duplication 19718026
esv2674955 CNV Deletion 23128226
essv1889 CNV CNV 17122850
dgv2267e1 CNV Complex 17122850
esv2668459 CNV Deletion 23128226
nsv442127 CNV CNV 18776908
dgv7990n71 CNV Gain 21882294
dgv7991n71 CNV Gain 21882294

Relevant External Links for CBWD1 Gene

HapMap Linkage Disequilibrium report
CBWD1

Disorders for CBWD1 Gene

No disorders were found for CBWD1 Gene.

No data available for UniProtKB/Swiss-Prot for CBWD1 Gene

Publications for CBWD1 Gene

  1. Diverse fates of paralogs following segmental duplication of telomeric genes. (PMID: 15233989) Wong A. … Ledbetter D.H. (Genomics 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  4. Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization. (PMID: 11489251) Shi J. … Xie Y. (Brain Res. 2001) 3 4
  5. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PMID: 12421752) Fan Y. … Trask B.J. (Genome Res. 2002) 2 3

Products for CBWD1 Gene

Sources for CBWD1 Gene

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