Aliases for CBSL Gene
Aliases for CBSL Gene
External Ids for CBSL Gene
- HGNC: 51829
- Entrez Gene: 102724560
- Ensembl: ENSG00000274276
- UniProtKB: P0DN79
Summaries for CBSL Gene
GeneCards Summary for CBSL Gene
CBSL (Cystathionine-Beta-Synthase Like) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Sulfur amino acid metabolism. An important paralog of this gene is CBS.
UniProtKB/Swiss-Prot for CBSL Gene
-
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBSL Gene
Genomics for CBSL Gene
Regulatory Elements for CBSL Gene
Enhancers for CBSL Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH21G006436 | 0.2 | Ensembl | 0.3 | +31.1 | 31144 | 1.5 | CBSL ENSG00000276902 | |
| GH21G006428 | 0.2 | Ensembl | 0.3 | +39.6 | 39607 | 0.2 | CBSL ENSG00000276902 | |
| GH21G006444 | 0.2 | Ensembl | 0.3 | +23.6 | 23606 | 0.6 | CBSL ENSG00000276902 | |
| GH21G006368 | 0.2 | Ensembl | 0.1 | +97.1 | 97107 | 6.0 | ENSG00000276902 CBSL |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CBSL on UCSC Golden Path with GeneCards custom track
Promoters for CBSL Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|---|---|---|
| ENSR00000140159 | 1107 | 2401 |
Regulatory Element Products
Genomic Location for CBSL Gene
- Chromosome:
- 21
- Start:
- 6,444,869 bp from pter
- End:
- 6,468,507 bp from pter
- Size:
- 23,639 bases
- Orientation:
- Minus strand
Genomic View for CBSL Gene
Genes around CBSL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21p12 by Ensembl
- 21p12 by Entrez Gene
- 21p12 by HGNC
CBSL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBSL Gene
Proteins for CBSL Gene
-
Protein details for CBSL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0DN79-CBSL_HUMAN
- Recommended name:
- Cystathionine beta-synthase-like protein
- Protein Accession:
- P0DN79
Protein attributes for CBSL Gene
- Size:
- 551 amino acids
- Molecular mass:
- 60587 Da
- Cofactor:
- Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
- Quaternary structure:
-
- Homotetramer.
Post-translational modifications for CBSL Gene
Other Protein References for CBSL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for CBSL
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CBSL
- Origene Custom Protein Services for CBSL
- Search GeneTex for Proteins for CBSL
Assay Products
No data available for DME Specific Peptides for CBSL Gene
Domains & Families for CBSL Gene
Protein Domains for CBSL Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
P0DN79UniProtKB/Swiss-Prot:
CBSL_HUMAN :- Belongs to the cysteine synthase/cystathionine beta-synthase family.
- Family:
-
- Belongs to the cysteine synthase/cystathionine beta-synthase family.
No data available for Gene Families and Suggested Antigen Peptide Sequences for CBSL Gene
Function for CBSL Gene
Molecular function for CBSL Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- L-serine + L-homocysteine = L-cystathionine + H(2)O.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Allosterically activated by S-adenosyl-methionine/AdoMet. Activated by S-adenosylhomocysteine/AdoHcy. Binds non-covalently to a heme group that may control the redox sensitivity of the enzyme.
- UniProtKB/Swiss-Prot Function:
- Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.
Enzyme Numbers (IUBMB) for CBSL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004122 | cystathionine beta-synthase activity | IEA | -- |
| GO:0016829 | lyase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for CBSL Gene
- MGI mutant phenotypes for CBSL:
-
inferred from 1 alleles
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- immune system phenotype
- muscle phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- respiratory system phenotype
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- integument phenotype
- limbs/digits/tail phenotype
- embryo phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
Animal Models for CBSL Gene
- MGI Knock Outs for CBSL:
-
- Cbs tm1Unc
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBSL
-
- Search ViGene Biosciences for CBSL
CRISPR Products
- Browse CRISPR knockouts for CBSL
miRNA Products
- Search ViGene Biosciences for CBSL
Inhibitory RNA Products
- Search ViGene Biosciences for CBSL
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CBSL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBSL
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
- Search ViGene Biosciences for CBSL
Flow Cytometry Products
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CBSL Gene
Localization for CBSL Gene
Subcellular locations from UniProtKB/Swiss-Prot for CBSL Gene
- Cytoplasm. Nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
No data available for Subcellular locations from COMPARTMENTS for CBSL Gene
Pathways & Interactions for CBSL Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation | ||
| 2 | Sulfur amino acid metabolism | ||
| 3 | Metabolism |
.37
|
|
| 4 | Carbon metabolism | ||
| 5 | Glycine, serine and threonine metabolism | ||
Pathways by source for CBSL Gene
4 KEGG pathways for CBSL Gene
UniProtKB/Swiss-Prot P0DN79-CBSL_HUMAN
- Pathway: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.
Interacting Proteins for CBSL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006535 | cysteine biosynthetic process from serine | IEA | -- |
| GO:0008652 | cellular amino acid biosynthetic process | IEA | -- |
| GO:0019343 | cysteine biosynthetic process via cystathionine | IEA | -- |
| GO:0019344 | cysteine biosynthetic process | IEA | -- |
No data available for SIGNOR curated interactions for CBSL Gene
Transcripts for CBSL Gene
mRNA/cDNA for CBSL Gene
- (16) REFSEQ mRNAs :
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for CBSL
miRNA Products
- Search ViGene Biosciences for CBSL
Inhibitory RNA Products
- Search ViGene Biosciences for CBSL
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CBSL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBSL
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CBSL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Glial Cells
- Protoplasmic Astrocyte Cells Neocortex
NURSA nuclear receptor signaling pathways regulating expression of CBSL Gene:
CBSLPrimer Products
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBSL Gene
Orthologs for CBSL Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CBS 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CBS 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CBS 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cbs 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cbs 34 16 |
|
||
| chicken (Gallus gallus) |
Aves | CBS 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cbs 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cbsa 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000162 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Cbs 34 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AGR012C 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CYS4 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F09317g 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os06g0564500 34 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU08216 34 |
|
- Species where no ortholog for CBSL was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CBSL Gene
Variants for CBSL Gene
Relevant External Links for CBSL Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CBSL
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for CBSL Gene
Disorders for CBSL Gene
Relevant External Links for CBSL
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CBSL
No disorders were found for CBSL Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBSL Gene
Publications for CBSL Gene
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
- Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
- Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4 64
Products for CBSL Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CBSL
- Origene Custom Protein Services for CBSL
- Browse OriGene Inhibitory RNA Products For CBSL
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for CBSL
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CBSL
- GenScript: Next-day shipping cDNA ORF clone for CBSL in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CBSL
- GenScript Custom Assay Services for CBSL
- GenScript Custom overexpressing Cell Line Services for CBSL
- Browse GenScript CRISPR for CBSL
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CBSL
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Search ViGene Biosciences for CBSL
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBSL
- VectorBuilder custom plasmid, inducible vectors for CBSL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBSL
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CBSL Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer