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Aliases for CBSL Gene

Aliases for CBSL Gene

  • Cystathionine-Beta-Synthase Like 2 3 5
  • Serine Sulfhydrase 3 4
  • Beta-Thionase 3 4
  • Cystathionine Beta-Synthase-Like Protein 3
  • EC 4.2.1.22 4

External Ids for CBSL Gene

Summaries for CBSL Gene

GeneCards Summary for CBSL Gene

CBSL (Cystathionine-Beta-Synthase Like) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Metabolism. An important paralog of this gene is CBS.

UniProtKB/Swiss-Prot for CBSL Gene

  • Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.

Additional gene information for CBSL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBSL Gene

Genomics for CBSL Gene

Regulatory Elements for CBSL Gene

Enhancers for CBSL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21H006428 0.2 Ensembl 0.3 +39.6 39607 0 CBSL ENSG00000276902
GH21H006436 0.2 Ensembl 0.3 +31.1 31144 1 CBSL ENSG00000276902
GH21H006444 0.2 Ensembl 0.3 +23.6 23606 0 CBSL ENSG00000276902
GH21H006368 0.2 Ensembl 0.1 +97.1 97107 6 ENSG00000276902 CBSL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CBSL on UCSC Golden Path with GeneCards custom track

Promoters for CBSL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000140159 1107 2401

Genomic Location for CBSL Gene

Chromosome:
21
Start:
6,444,869 bp from pter
End:
6,468,507 bp from pter
Size:
23,639 bases
Orientation:
Minus strand

Genomic View for CBSL Gene

Genes around CBSL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBSL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBSL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBSL Gene

Proteins for CBSL Gene

  • Protein details for CBSL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DN79-CBSL_HUMAN
    Recommended name:
    Cystathionine beta-synthase-like protein
    Protein Accession:
    P0DN79

    Protein attributes for CBSL Gene

    Size:
    551 amino acids
    Molecular mass:
    60587 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homotetramer.

neXtProt entry for CBSL Gene

Post-translational modifications for CBSL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CBSL Gene

Domains & Families for CBSL Gene

Gene Families for CBSL Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for CBSL Gene

Graphical View of Domain Structure for InterPro Entry

P0DN79

UniProtKB/Swiss-Prot:

CBSL_HUMAN :
  • Belongs to the cysteine synthase/cystathionine beta-synthase family.
Family:
  • Belongs to the cysteine synthase/cystathionine beta-synthase family.
genes like me logo Genes that share domains with CBSL: view

No data available for Suggested Antigen Peptide Sequences for CBSL Gene

Function for CBSL Gene

Molecular function for CBSL Gene

UniProtKB/Swiss-Prot CatalyticActivity:
L-serine + L-homocysteine = L-cystathionine + H(2)O.
UniProtKB/Swiss-Prot EnzymeRegulation:
Allosterically activated by S-adenosyl-methionine/AdoMet. Activated by S-adenosylhomocysteine/AdoHcy. Binds non-covalently to a heme group that may control the redox sensitivity of the enzyme.
UniProtKB/Swiss-Prot Function:
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.

Enzyme Numbers (IUBMB) for CBSL Gene

Gene Ontology (GO) - Molecular Function for CBSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004122 cystathionine beta-synthase activity IEA --
GO:0016829 lyase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CBSL: view
genes like me logo Genes that share phenotypes with CBSL: view

Animal Models for CBSL Gene

MGI Knock Outs for CBSL:

Animal Model Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CBSL Gene

Localization for CBSL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBSL Gene

Cytoplasm. Nucleus.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CBSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CBSL: view

No data available for Subcellular locations from COMPARTMENTS for CBSL Gene

Pathways & Interactions for CBSL Gene

genes like me logo Genes that share pathways with CBSL: view

UniProtKB/Swiss-Prot P0DN79-CBSL_HUMAN

  • Pathway: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.

Interacting Proteins for CBSL Gene

Gene Ontology (GO) - Biological Process for CBSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006535 cysteine biosynthetic process from serine IEA --
GO:0008652 cellular amino acid biosynthetic process IEA --
GO:0019343 cysteine biosynthetic process via cystathionine IEA --
GO:0019344 cysteine biosynthetic process IEA --
genes like me logo Genes that share ontologies with CBSL: view

No data available for SIGNOR curated interactions for CBSL Gene

Drugs & Compounds for CBSL Gene

No Compound Related Data Available

Transcripts for CBSL Gene

mRNA/cDNA for CBSL Gene

(24) REFSEQ mRNAs :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CBSL Gene

No ASD Table

Relevant External Links for CBSL Gene

GeneLoc Exon Structure for
CBSL
ECgene alternative splicing isoforms for
CBSL

Expression for CBSL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CBSL Gene:

CBSL
genes like me logo Genes that share expression patterns with CBSL: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBSL Gene

Orthologs for CBSL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CBSL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CBS 33
  • 99.27 (n)
cow
(Bos Taurus)
Mammalia CBS 33
  • 87.84 (n)
dog
(Canis familiaris)
Mammalia CBS 33
  • 86.81 (n)
rat
(Rattus norvegicus)
Mammalia Cbs 33
  • 82.69 (n)
mouse
(Mus musculus)
Mammalia Cbs 33 16
  • 82.6 (n)
chicken
(Gallus gallus)
Aves CBS 33
  • 74.25 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cbs 33
  • 72.68 (n)
zebrafish
(Danio rerio)
Actinopterygii cbsa 33
  • 69.27 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000162 33
  • 60.22 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cbs 33
  • 59.58 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR012C 33
  • 55.46 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CYS4 33
  • 50.93 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F09317g 33
  • 50.53 (n)
rice
(Oryza sativa)
Liliopsida Os06g0564500 33
  • 47.51 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08216 33
  • 56.24 (n)
Species where no ortholog for CBSL was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBSL Gene

ENSEMBL:
Gene Tree for CBSL (if available)
TreeFam:
Gene Tree for CBSL (if available)

Paralogs for CBSL Gene

Paralogs for CBSL Gene

genes like me logo Genes that share paralogs with CBSL: view

Variants for CBSL Gene

Relevant External Links for CBSL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CBSL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for CBSL Gene

Disorders for CBSL Gene

Relevant External Links for CBSL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBSL

No disorders were found for CBSL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBSL Gene

Publications for CBSL Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60
  3. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4 60
  4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt KT … Blagoev B (Science signaling 2011) 4 60
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S … Mohammed S (Analytical chemistry 2009) 4 60

Products for CBSL Gene

Sources for CBSL Gene

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