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CBR4 Gene

protein-coding   GIFtS: 53
GCID: GC04M169815

Carbonyl Reductase 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carbonyl Reductase 41 2     Carbonyl Reductase Family Member 42
Quinone Reductase CBR42 3     Short Chain Dehydrogenase/Reductase Family 45C, Member 12
3-Oxoacyl-[Acyl-Carrier-Protein] Reductase2 3     EC 1.-.-.-3
Member 11     EC 1.1.1.-3
Short Chain Dehydrogenase/Reductase Family 45C1     EC 1.1.18
SDR45C12     EC 1.1.1.1008
Carbonic Reductase 42     

External Ids:    HGNC: 258911   Entrez Gene: 848692   Ensembl: ENSG000001454397   UniProtKB: Q8N4T83   

Export aliases for CBR4 gene to outside databases

Previous GC identifers: GC04M170283 GC04M170145 GC04M165662


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CBR4 Gene:
CBR4 (carbonyl reductase 4) is a protein-coding gene. Diseases associated with CBR4 include horner's syndrome, and pneumonia. GO annotations related to this gene include quinone binding and NAD(P)H dehydrogenase (quinone) activity. An important paralog of this gene is HPGD.

UniProtKB/Swiss-Prot: CBR4_HUMAN, Q8N4T8
Function: The heteroteramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity.
May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent
quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and
various other o-quinones and p-quinones (in vitro)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CBR4 gene promoter:
         TBP   POU3F1   Bach2   Pax-2   Pax-2a   HNF-1A   Pax-2b   HNF-1   HFH-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCBR4 promoter sequence
   Search Chromatin IP Primers for CBR4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CBR4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.3   Ensembl cytogenetic band:  4q32.3   HGNC cytogenetic band: 4q32.3

CBR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBR4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M169815:  view genomic region     (about GC identifiers)

Start:
169,784,921 bp from pter      End:
169,931,468 bp from pter
Size:
146,548 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CBR4_HUMAN, Q8N4T8 (See protein sequence)
Recommended Name: Carbonyl reductase family member 4  
Size: 237 amino acids; 25301 Da
Subunit: Homotetramer. Heterotetramer with HSD17B8; contains two molecules of HSD17B8 and CBR4
Secondary accessions: Q8WTW8 Q96K93
Alternative splicing: 2 isoforms:  Q8N4T8-1   Q8N4T8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CBR4: NX_Q8N4T8

Explore proteomics data for CBR4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys96, Lys140, Lys152, Lys187
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CBR4 (Q8N4T8) (see all 5)
     GGSRGIG  GSIVNVGS  VNVVAPGF  FLVNAAGINRD 


    See CBR4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116172.2  
    ENSEMBL proteins: 
     ENSP00000424717   ENSP00000303525   ENSP00000427615   ENSP00000423128   ENSP00000421254  
     ENSP00000425671  

    CBR4 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CBR4
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    Novus Biologicals CBR4 Proteins
    Novus Biologicals CBR4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CBR4
    Cloud-Clone Corp. Proteins for CBR4

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    CBR4 Assay Products:

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    Cloud-Clone Corp. CLIAs for CBR4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDRC1: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

    4 InterPro protein domains:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q8N4T8

    ProtoNet protein and cluster: Q8N4T8

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: CBR4_HUMAN, Q8N4T8
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    CBR4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBR4_HUMAN, Q8N4T8
    Function: The heteroteramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity.
    May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent
    quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and
    various other o-quinones and p-quinones (in vitro)
    Biophysicochemical properties: Kinetic parameters: KM=11 uM for NADPH; KM=1.6 uM for 9,10-phenanthrenequinone;
    KM=1.9 uM for 1,4-benzoquinone; pH dependence: Optimum pH is 6-8;

         Enzyme Numbers (IUBMB): EC 1.1.1.1002 EC 1.1.12 EC 1.1.1.-1 EC 1.-.-.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003955NAD(P)H dehydrogenase (quinone) activity IDA--
    GO:0005515protein binding IPI19571038
    GO:0008753NADPH dehydrogenase (quinone) activity ISS--
    GO:0016491oxidoreductase activity ----
    GO:0048038quinone binding ISS--
         
    CBR4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CBR4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CBR4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CBR4

    miRNA
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    miRTarBase miRNAs that target CBR4:
    hsa-let-7d-5p (MIRT032121), hsa-mir-1 (MIRT023498), hsa-mir-155-5p (MIRT020570)

    Block miRNA regulation of human, mouse, rat CBR4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CBR4 (see all 9):
    hsa-miR-3163 hsa-miR-196a* hsa-miR-374c hsa-miR-182 hsa-miR-3675-3p hsa-miR-655 hsa-miR-599 hsa-miR-15b*
    SwitchGear 3'UTR luciferase reporter plasmidCBR4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CBR4
    Predesigned siRNA for gene silencing in human, mouse, rat CBR4

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for CBR4 (see all 8)
    OriGene ORF clones in mouse, rat for CBR4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CBR4 (NM_032783)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBR4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBR4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CBR4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBR4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CBR4_HUMAN, Q8N4T8: Mitochondrion matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    golgi apparatus1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix ISS--

    CBR4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: CBR4_HUMAN, Q8N4T8
    Pathway: Lipid metabolism; fatty acid biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CBR4
    Interactions:

        Search GeneGlobe Interaction Network for CBR4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CBR4 (ENSP000003035254) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0008152metabolic process ----
    GO:0044597daunorubicin metabolic process IMP--
    GO:0044598doxorubicin metabolic process IMP--
    GO:0051289protein homotetramerization IPI19000905

    CBR4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CBR4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CBR4 gene: 
    NM_032783.4  

    Unigene Cluster for CBR4:

    Carbonyl reductase 4
    Hs.659311  [show with all ESTs]
    Unigene Representative Sequence: NM_032783
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510042(uc011cjy.2) ENST00000509108 ENST00000306193(uc003iry.3)
    ENST00000504480(uc003irz.2) ENST00000504561 ENST00000506808 ENST00000507752

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CBR4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CBR4 (see all 9):
    hsa-miR-3163 hsa-miR-196a* hsa-miR-374c hsa-miR-182 hsa-miR-3675-3p hsa-miR-655 hsa-miR-599 hsa-miR-15b*
    SwitchGear 3'UTR luciferase reporter plasmidCBR4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CBR4
    Predesigned siRNA for gene silencing in human, mouse, rat CBR4
    Clone
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    OriGene clones in human, mouse for CBR4 (see all 8)
    OriGene ORF clones in mouse, rat for CBR4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CBR4 (NM_032783)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBR4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBR4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CBR4
    OriGene qSTAR qPCR primer pairs in human, mouse for CBR4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBR4
      QuantiTect SYBR Green Assays in human, mouse, rat CBR4
      QuantiFast Probe-based Assays in human, mouse, rat CBR4

    Additional mRNA sequence: 

    AK027337.1 AK291756.1 AL049442.1 AL833393.1 BC021973.2 BC033650.1 

    11 DOTS entries:

    DT.208506  DT.100817086  DT.100817089  DT.121241929  DT.121241863  DT.121241970  DT.40127198  DT.91847597 
    DT.121242004  DT.97821654  DT.40288175 

    Selected AceView cDNA sequences (see all 80):

    BM466406 AW304923 BI259796 BX100983 AI148822 CB132625 CB070392 AA992811 
    BM722991 CB853053 CR595317 CA418785 BM473021 BI914473 AA679646 BC021973 
    NM_032783 BX441923 AW002842 AA730907 BG403642 BF431622 AA136080 BG116516 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CBR4 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
    SP1:              -     -                             -                 -                           
    SP2:              -     -                             -                 -     -     -               
    SP3:                                                  -                 -                           
    SP4:              -                                                                                 
    SP5:              -     -                             -                                             


    ECgene alternative splicing isoforms for CBR4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CBR4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGGCTTTA
    CBR4 Expression
    About this image

    CBR4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CBR4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.659311

    UniProtKB/Swiss-Prot: CBR4_HUMAN, Q8N4T8
    Tissue specificity: Detected in liver and kidney (at protein level)

        Custom PCR Arrays for CBR4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBR4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CBR4 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cbr41 , 5 carbonyl reductase 41, 5 86.04(n)1
    87.18(a)1
      8 (31.18 cM)5
    2343091  NM_145595.21  NP_663570.21 
     614877345 
    chicken
    (Gallus gallus)
    Aves CBR41 carbonyl reductase 4 74.12(n)
    72.57(a)
      422435  XM_004940932.1  XP_004940989.1 
    lizard
    (Anolis carolinensis)
    Reptilia CBR46
    carbonyl reductase 4
    76(a)
    1 ↔ 1
    GL343216.1(508833-521176)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.115452 Xenopus laevis transcribed sequence with weak similarity more 74.8(n)    BX842804.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cbr41 carbonyl reductase 4 62.01(n)
    63.98(a)
      402954  NM_205656.1  NP_991219.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G243601 AT1G24360 49.43(n)
    42.31(a)
      839053  NM_102282.3  NP_564216.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g02427001 Os12g0242700 46.76(n)
    42.48(a)
      4351870  NM_001073013.1  NP_001066481.1 


    ENSEMBL Gene Tree for CBR4 (if available)
    TreeFam Gene Tree for CBR4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CBR4 gene
    HPGD2  DCXR2  DECR22  PECR2  HSD17B142  DHRS22  HSD17B102  DHRS42  
    BDH22  DHRS4L22  HSD17B82  DECR12  
    9 SIMAP similar genes for CBR4 using alignment to 5 protein entries:     CBR4_HUMAN (see all proteins):
    HSD17B10    HSD17B8    DHRS4    HSD17B14    BDH2    DHRS4L1
    DECR2    DHRS2    HPGD

    CBR4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CBR4 (see all 502)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1851156301,2
    C--169908259(+) TCTCCA/GTTTGG 1 -- int10--------
    rs283685131,2
    C,F--169908264(+) ATTTGG/TATTAT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1879495771,2
    --169908518(+) TTTTAC/GTGCAT 1 -- int10--------
    rs1924213991,2
    --169908522(+) ACTGCA/GTATAT 1 -- int10--------
    rs1848177261,2
    C--169908562(+) TGTGGA/G/TTATCA 1 -- int10--------
    rs96839881,2
    C,F,A,H--169908628(+) CTAAAT/GGAATG 1 -- int15Minor allele frequency- G:0.01NS EA WA 536
    rs170546031,2
    C,F,H--169908706(+) TCTTAT/CAGTTG 1 -- int120Minor allele frequency- C:0.14NA NS EA WA 2114
    rs1130333241,2
    F--169908737(+) ATCAGG/AAAGTT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1926768791,2
    --169908932(+) AATTAA/GATTAT 1 -- ut310--------
    rs1849748761,2
    --169909145(+) GCTCAC/TAGGAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CBR4 (169784921 - 169931468 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CBR4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34043CNV Loss18971310
    nsv880897CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for CBR4:    
    About MalaCards
    horner's syndrome    pneumonia    tuberculosis

    1 disease from the University of Copenhagen DISEASES database for CBR4:
    Horner's syndrome

    CBR4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CBR4
    Human Genome Epidemiology (HuGE) Navigator: CBR4 (1 document)

    Export disorders for CBR4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CBR4 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with CBR4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. 17beta-Hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS. (PubMed id 19571038)1, 2 Chen Z.... Hiltunen J.K. (FASEB J. 2009)
    3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    4. Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase. (PubMed id 19000905)1, 2 Endo S....Hara A. (Biochem. Biophys. Res. Commun. 2008)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84869 HGNC: 25891 AceView: CBR4 Ensembl:ENSG00000145439 euGenes: HUgn84869
    ECgene: CBR4 H-InvDB: CBR4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CBR4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CBR4 gene:
    Search GeneIP for patents involving CBR4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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