Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CBR4 Gene

Aliases for CBR4 Gene

  • Carbonyl Reductase 4 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 45C Member 1 3 4
  • 3-Oxoacyl-[Acyl-Carrier-Protein] Reductase 3 4
  • Quinone Reductase CBR4 3 4
  • SDR45C1 3 4
  • Short Chain Dehydrogenase/Reductase Family 45C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 45C 2
  • Carbonic Reductase 4 3
  • EC 1.1.1.100 63
  • EC 1.-.-.- 4
  • EC 1.1.1.- 4
  • Member 1 2
  • EC 1.1.1 63

External Ids for CBR4 Gene

Previous GeneCards Identifiers for CBR4 Gene

  • GC04M170283
  • GC04M170145
  • GC04M169815
  • GC04M165662

Summaries for CBR4 Gene

GeneCards Summary for CBR4 Gene

CBR4 (Carbonyl Reductase 4) is a Protein Coding gene. Diseases associated with CBR4 include horner's syndrome and autonomic nervous system disease. GO annotations related to this gene include oxidoreductase activity and NADPH binding. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for CBR4 Gene

  • The heteroteramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBR4 Gene

Genomics for CBR4 Gene

Regulatory Elements for CBR4 Gene

Promoters for CBR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CBR4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CBR4 Gene

Chromosome:
4
Start:
168,863,770 bp from pter
End:
169,010,317 bp from pter
Size:
146,548 bases
Orientation:
Minus strand

Genomic View for CBR4 Gene

Genes around CBR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBR4 Gene

Proteins for CBR4 Gene

  • Protein details for CBR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4T8-CBR4_HUMAN
    Recommended name:
    Carbonyl reductase family member 4
    Protein Accession:
    Q8N4T8
    Secondary Accessions:
    • Q8WTW8
    • Q96K93

    Protein attributes for CBR4 Gene

    Size:
    237 amino acids
    Molecular mass:
    25301 Da
    Quaternary structure:
    • Homotetramer. Heterotetramer with HSD17B8; contains two molecules of HSD17B8 and CBR4.

    Three dimensional structures from OCA and Proteopedia for CBR4 Gene

    Alternative splice isoforms for CBR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CBR4 Gene

Proteomics data for CBR4 Gene at MOPED

Selected DME Specific Peptides for CBR4 Gene

Post-translational modifications for CBR4 Gene

  • Ubiquitination at Lys 96, Lys 140, Lys 152, and Lys 187
  • Modification sites at PhosphoSitePlus

Other Protein References for CBR4 Gene

Domains & Families for CBR4 Gene

Gene Families for CBR4 Gene

Suggested Antigen Peptide Sequences for CBR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4T8

UniProtKB/Swiss-Prot:

CBR4_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with CBR4: view

Function for CBR4 Gene

Molecular function for CBR4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=11 uM for NADPH; KM=1.6 uM for 9,10-phenanthrenequinone; KM=1.9 uM for 1,4-benzoquinone; pH dependence: Optimum pH is 6-8.;
UniProtKB/Swiss-Prot Function:
The heteroteramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro).

Enzyme Numbers (IUBMB) for CBR4 Gene

Gene Ontology (GO) - Molecular Function for CBR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003955 NAD(P)H dehydrogenase (quinone) activity IDA 20837989
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with CBR4: view
genes like me logo Genes that share phenotypes with CBR4: view

Animal Model Products

miRNA for CBR4 Gene

miRTarBase miRNAs that target CBR4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBR4 Gene

Localization for CBR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBR4 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBR4 Gene COMPARTMENTS Subcellular localization image for CBR4 gene
Compartment Confidence
mitochondrion 5
cytosol 2
golgi apparatus 1
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CBR4 Gene

Pathways & Interactions for CBR4 Gene

SuperPathways for CBR4 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N4T8-CBR4_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis.

Interacting Proteins for CBR4 Gene

Gene Ontology (GO) - Biological Process for CBR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CBR4: view

No data available for Pathways by source and SIGNOR curated interactions for CBR4 Gene

Drugs & Compounds for CBR4 Gene

No Compound Related Data Available

Transcripts for CBR4 Gene

Unigene Clusters for CBR4 Gene

Carbonyl reductase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CBR4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
SP1: - - - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - -
SP7:
SP8: - - - - -

Relevant External Links for CBR4 Gene

GeneLoc Exon Structure for
CBR4
ECgene alternative splicing isoforms for
CBR4

Expression for CBR4 Gene

mRNA expression in normal human tissues for CBR4 Gene

Protein differential expression in normal tissues from HIPED for CBR4 Gene

This gene is overexpressed in Liver (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CBR4 Gene



SOURCE GeneReport for Unigene cluster for CBR4 Gene Hs.659311

mRNA Expression by UniProt/SwissProt for CBR4 Gene

Q8N4T8-CBR4_HUMAN
Tissue specificity: Detected in liver and kidney (at protein level).
genes like me logo Genes that share expression patterns with CBR4: view

Protein tissue co-expression partners for CBR4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CBR4 Gene

Orthologs for CBR4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CBR4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CBR4 35
  • 85.37 (n)
  • 86.92 (a)
CBR4 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC477352 35
  • 91 (n)
  • 92.41 (a)
CBR4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cbr4 35
  • 86.04 (n)
  • 87.18 (a)
Cbr4 16
Cbr4 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CBR4 35
  • 99.72 (n)
  • 99.58 (a)
CBR4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cbr4 35
  • 84.9 (n)
  • 85.47 (a)
oppossum
(Monodelphis domestica)
Mammalia CBR4 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CBR4 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves CBR4 35
  • 74.12 (n)
  • 72.57 (a)
CBR4 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CBR4 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cbr4 35
  • 66.95 (n)
  • 67.09 (a)
Str.15559 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.11545 35
zebrafish
(Danio rerio)
Actinopterygii cbr4 35
  • 62.01 (n)
  • 63.98 (a)
cbr4 36
  • 65 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G24360 35
  • 49.43 (n)
  • 42.31 (a)
rice
(Oryza sativa)
Liliopsida Os12g0242700 35
  • 46.76 (n)
  • 42.48 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03525 35
  • 46.17 (n)
  • 36.9 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes oar2 35
  • 45.35 (n)
  • 35.59 (a)
Species with no ortholog for CBR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBR4 Gene

ENSEMBL:
Gene Tree for CBR4 (if available)
TreeFam:
Gene Tree for CBR4 (if available)

Paralogs for CBR4 Gene

(9) SIMAP similar genes for CBR4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CBR4: view

Variants for CBR4 Gene

Sequence variations from dbSNP and Humsavar for CBR4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2877380 - 169,007,691(-) AAGAG(A/C)TGGAG intron-variant, nc-transcript-variant, reference, missense
rs3942 -- 168,974,991(+) ttgtc(A/G)tatta intron-variant
rs8484 -- 169,001,293(-) CACCT(A/G)ATGGG intron-variant
rs11894 -- 169,001,353(+) tgtaa(C/T)cttag intron-variant
rs1115717 -- 168,942,819(+) tgaac(A/G)gatat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CBR4 Gene

Variant ID Type Subtype PubMed ID
nsv880897 CNV Gain 21882294
esv34043 CNV Loss 18971310

Variation tolerance for CBR4 Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CBR4 Gene

HapMap Linkage Disequilibrium report
CBR4
Human Gene Mutation Database (HGMD)
CBR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBR4 Gene

Disorders for CBR4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CBR4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
horner's syndrome
  • bernard horner syndrome
autonomic nervous system disease
  • autonomic nervous system disorder
- elite association - COSMIC cancer census association via MalaCards
Search CBR4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CBR4

Genetic Association Database (GAD)
CBR4
Human Genome Epidemiology (HuGE) Navigator
CBR4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBR4
genes like me logo Genes that share disorders with CBR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CBR4 Gene

Publications for CBR4 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin. (PMID: 20837989) Bains O.S. … Riggs K.W. (J. Pharmacol. Exp. Ther. 2010) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for CBR4 Gene

Sources for CBR4 Gene

Back to Top

Content