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Aliases for CBR4 Gene

Aliases for CBR4 Gene

  • Carbonyl Reductase 4 2 3
  • Short Chain Dehydrogenase/Reductase Family 45C Member 1 3 4
  • 3-Oxoacyl-[Acyl-Carrier-Protein] Reductase 3 4
  • Quinone Reductase CBR4 3 4
  • SDR45C1 3 4
  • Short Chain Dehydrogenase/Reductase Family 45C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 45C 2
  • Carbonyl Reductase Family Member 4 3
  • Carbonic Reductase 4 3
  • EC 1.1.1.100 63
  • EC 1.-.-.- 4
  • EC 1.1.1.- 4
  • Member 1 2
  • EC 1.1.1 63

External Ids for CBR4 Gene

Previous GeneCards Identifiers for CBR4 Gene

  • GC04M170283
  • GC04M170145
  • GC04M169815
  • GC04M165662

Summaries for CBR4 Gene

GeneCards Summary for CBR4 Gene

CBR4 (Carbonyl Reductase 4) is a Protein Coding gene. GO annotations related to this gene include quinone binding and NAD(P)H dehydrogenase (quinone) activity. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for CBR4 Gene

  • The heteroteramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBR4 Gene

Genomics for CBR4 Gene

Regulatory Elements for CBR4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CBR4 Gene

Start:
168,863,770 bp from pter
End:
169,010,317 bp from pter
Size:
146,548 bases
Orientation:
Minus strand

Genomic View for CBR4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CBR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBR4 Gene

Proteins for CBR4 Gene

  • Protein details for CBR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4T8-CBR4_HUMAN
    Recommended name:
    Carbonyl reductase family member 4
    Protein Accession:
    Q8N4T8
    Secondary Accessions:
    • Q8WTW8
    • Q96K93

    Protein attributes for CBR4 Gene

    Size:
    237 amino acids
    Molecular mass:
    25301 Da
    Quaternary structure:
    • Homotetramer. Heterotetramer with HSD17B8; contains two molecules of HSD17B8 and CBR4.

    Three dimensional structures from OCA and Proteopedia for CBR4 Gene

    Alternative splice isoforms for CBR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CBR4 Gene

Proteomics data for CBR4 Gene at MOPED

Selected DME Specific Peptides for CBR4 Gene

Post-translational modifications for CBR4 Gene

  • Ubiquitination at Lys96, Lys140, Lys152, and Lys187
  • Modification sites at PhosphoSitePlus

Other Protein References for CBR4 Gene

Domains for CBR4 Gene

Gene Families for CBR4 Gene

HGNC:
  • SDRC1 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

Suggested Antigen Peptide Sequences for CBR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4T8

UniProtKB/Swiss-Prot:

CBR4_HUMAN :
  • Q8N4T8
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with CBR4: view

Function for CBR4 Gene

Molecular function for CBR4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=11 uM for NADPH; KM=1.6 uM for 9,10-phenanthrenequinone; KM=1.9 uM for 1,4-benzoquinone; pH dependence: Optimum pH is 6-8.;
UniProtKB/Swiss-Prot Function: The heteroteramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro).

Enzyme Numbers (IUBMB) for CBR4 Gene

Gene Ontology (GO) - Molecular Function for CBR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003955 NAD(P)H dehydrogenase (quinone) activity IDA 20837989
GO:0005515 protein binding IPI 19571038
GO:0008753 NADPH dehydrogenase (quinone) activity ISS --
GO:0016491 oxidoreductase activity --
GO:0048038 quinone binding ISS --
genes like me logo Genes that share ontologies with CBR4: view

Animal Model Products

CRISPR Products

miRNA for CBR4 Gene

miRTarBase miRNAs that target CBR4

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CBR4 Gene

Localization for CBR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBR4 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBR4 Gene COMPARTMENTS Subcellular localization image for CBR4 gene
Compartment Confidence
mitochondrion 5
cytosol 2
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CBR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix ISS --
genes like me logo Genes that share ontologies with CBR4: view

Pathways for CBR4 Gene

SuperPathways for CBR4 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N4T8-CBR4_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis

Interacting Proteins for CBR4 Gene

Gene Ontology (GO) - Biological Process for CBR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006633 fatty acid biosynthetic process IEA --
GO:0008152 metabolic process --
GO:0044597 daunorubicin metabolic process IMP 20837989
GO:0044598 doxorubicin metabolic process IMP 20837989
GO:0051289 protein homotetramerization IPI 19000905
genes like me logo Genes that share ontologies with CBR4: view

No data available for Pathways by source for CBR4 Gene

Transcripts for CBR4 Gene

Unigene Clusters for CBR4 Gene

Carbonyl reductase 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CBR4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CBR4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
SP1: - - - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - -
SP7:
SP8: - - - - -

Relevant External Links for CBR4 Gene

GeneLoc Exon Structure for
CBR4
ECgene alternative splicing isoforms for
CBR4

Expression for CBR4 Gene

mRNA expression in normal human tissues for CBR4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CBR4 Gene

SOURCE GeneReport for Unigene cluster for CBR4 Gene Hs.659311

mRNA Expression by UniProt/SwissProt for CBR4 Gene

Q8N4T8-CBR4_HUMAN
Tissue specificity: Detected in liver and kidney (at protein level).
genes like me logo Genes that share expressions with CBR4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CBR4 Gene

Orthologs for CBR4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CBR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CBR4 35
  • 99.72 (n)
  • 99.58 (a)
CBR4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CBR4 35
  • 85.37 (n)
  • 86.92 (a)
CBR4 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CBR4 36
  • 92 (a)
OneToOne
LOC477352 35
  • 91 (n)
  • 92.41 (a)
mouse
(Mus musculus)
Mammalia Cbr4 35
  • 86.04 (n)
  • 87.18 (a)
Cbr4 16
Cbr4 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CBR4 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CBR4 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cbr4 35
  • 84.9 (n)
  • 85.47 (a)
chicken
(Gallus gallus)
Aves CBR4 35
  • 74.12 (n)
  • 72.57 (a)
CBR4 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CBR4 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11545 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cbr4 35
  • 66.95 (n)
  • 67.09 (a)
Str.15559 35
zebrafish
(Danio rerio)
Actinopterygii cbr4 35
  • 62.01 (n)
  • 63.98 (a)
cbr4 36
  • 65 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G24360 35
  • 49.43 (n)
  • 42.31 (a)
rice
(Oryza sativa)
Liliopsida Os12g0242700 35
  • 46.76 (n)
  • 42.48 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03525 35
  • 46.17 (n)
  • 36.9 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes oar2 35
  • 45.35 (n)
  • 35.59 (a)
Species with no ortholog for CBR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBR4 Gene

ENSEMBL:
Gene Tree for CBR4 (if available)
TreeFam:
Gene Tree for CBR4 (if available)

Paralogs for CBR4 Gene

Selected SIMAP similar genes for CBR4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CBR4: view

Variants for CBR4 Gene

Sequence variations from dbSNP and Humsavar for CBR4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3942 -- 168,974,991(+) ttgtc(A/G)tatta intron-variant
rs8484 -- 169,001,293(-) CACCT(A/G)ATGGG intron-variant
rs11894 -- 169,001,353(+) tgtaa(C/T)cttag intron-variant
rs898002 -- 168,996,094(+) CACAA(C/T)CTCTC intron-variant
rs1061504 -- 168,995,178(-) AAGAA(C/T)TGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CBR4 Gene

Variant ID Type Subtype PubMed ID
nsv880897 CNV Gain 21882294
esv34043 CNV Loss 18971310

Relevant External Links for CBR4 Gene

HapMap Linkage Disequilibrium report
CBR4
Human Gene Mutation Database (HGMD)
CBR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBR4 Gene

Disorders for CBR4 Gene

(1) University of Copenhagen DISEASES for CBR4 Gene

Relevant External Links for CBR4

Genetic Association Database (GAD)
CBR4
Human Genome Epidemiology (HuGE) Navigator
CBR4
genes like me logo Genes that share disorders with CBR4: view

No data available for UniProtKB/Swiss-Prot for CBR4 Gene

Publications for CBR4 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase. (PMID: 19000905) Endo S. … Hara A. (Biochem. Biophys. Res. Commun. 2008) 3 4
  4. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  5. 17beta-Hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS. (PMID: 19571038) Chen Z. … Hiltunen J.K. (FASEB J. 2009) 3 4

Products for CBR4 Gene

Sources for CBR4 Gene

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