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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CBR3 Gene

protein-coding   GIFtS: 64
GCID: GC21P037507

carbonyl reductase 3
 Explore 11 diseases affiliated with
CBR3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CBR3    

Aliases
for CBR3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
Aliases
Carbonyl Reductase 31 2     Carbonyl Reductase (NADPH) 32
SDR21C21 2     Carbonyl Reductase [NADPH] 32
NADPH-Dependent Carbonyl Reductase 32 3     HCBR31
EC 1.1.1.1843 8     Short Chain Dehydrogenase/Reductase Family 21C, Member 22
Carbonyl Reductase (NADPH) 3, EC 1.1.1.18411     EC 1.1.18

External Ids:    HGNC: 15491   Entrez Gene: 8742   Ensembl: ENSG000001592317   OMIM: 6036085   UniProtKB: O758283   

Export aliases for CBR3 gene to outside databases

Previous GC identifers: GC21P034084 GC21P034167 GC21P036427 GC21P036429 GC21P022984


Summaries
for CBR3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CBR3:
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl
compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase.
CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CBR3_HUMAN, O75828
Function: Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro)

Gene Wiki entry for CBR3


Genomic Views
for CBR3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CBR3 gene promoter:
         HFH-3   Lmo2   STAT5A   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx5-1   POU3F2   FOXI1   CBF-A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CBR3 promoter sequence

   Search SABiosciences Chromatin IP Primers for CBR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.2   Ensembl cytogenetic band:  21q22.12   HGNC cytogenetic band: 21q22.2
Nature(405: 311-319) cytogenetic band:   21q22.13
CBR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBR3 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P037507:   GeneLoc Nature:405,311-319
Start:
 37,507,210 bp from pter       23,084,242 bp from centromere
End:
 37,518,864 bp from pter 23,095,605 bp from centromere
Size:
 11,655 bases 11,364 bases
Orientation:
 plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: AB004854
genomic clones: KB795B7


Proteins
for CBR3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CBR3_HUMAN, O75828 (See protein sequence)
Recommended Name: Carbonyl reductase [NADPH] 3  
Size: 277 amino acids; 30850 Da
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for CBR3:
2HRB (3D)    
Secondary accessions: Q6FHP2

Explore the universe of human proteins at neXtProt for CBR3: NX_O75828

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75828

    • 4 DME Specific Peptides for CBR3 (O75828)
     KFVEDTK  GRVVNISS  QSIRALRDFL  AAVQQLQAEGLSP 

    CBR3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001227.1  
    ENSEMBL proteins: 
     ENSP00000290354  

    Human Recombinant Protein Products: 
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    Novus Biologicals CBR3 Proteins
    Novus Biologicals CBR3 Lysates
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    ProSpec Recombinant Protein for CBR3
    Uscn Proteins for CBR3

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA18493841


    CBR3 for ontologies           About GeneDecksing



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    Uscn Antibodies for CBR3
    Search ThermoFisher Antibodies for CBR3

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    Uscn ELISAs and CLIAs for CBR3

    Protein Domains /
    Families
    for CBR3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CBR3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry O75828

    ProtoNet protein and cluster: O75828

    2 Blocks protein families:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: CBR3_HUMAN, O75828
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    Function
    for CBR3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CBR3_HUMAN, O75828
    Function: Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro)
    Catalytic activity: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH
    Biophysicochemical properties: Kinetic parameters: KM=25 uM for menadione (PubMed:15537833); KM=43 uM for menadione
    (PubMed:18493841); KM=90 uM for NADPH (PubMed:15537833); KM=38 uM for NADPH (PubMed:18493841); pH dependence: Optimum
    pH is 5.5-7;

         Genatlas biochemistry entry for CBR3:
    carbonyl reductase,NADPH-dependent oxidoreductase

    Enzyme Numbers (IUBMB): EC 1.1.1.1841 2 EC 1.1.12

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CBR3 (see all 7)
    OriGene shRNA RFP: CBR3
    OriGene siRNA: CBR3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CBR3

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBR3 (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBR3 

    Cell Line
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    Search LifeMap BioReagents cell lines for CBR3

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00002533-keto sterol reductase activity IEA--
    GO:0004090carbonyl reductase (NADPH) activity IDA18493841
    GO:0070402NADPH binding IDA18493841


    CBR3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CBR3:
     Synthetic lethal with Ras 


    Pathways & Interactions
    for CBR3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    		Prostaglandin 2 biosynthesis and metabolism FM0.44
    		Prostaglandin 2 biosynthesis and metabolism FM0.44
    2Doxorubicin Pathway, Pharmacokinetics
    		Doxorubicin Pathway, Pharmacokinetics1.00
    3Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics
    		Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics1.00
    4Arachidonic acid metabolism
    		Arachidonic acid metabolism0.42
    5Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CBR3
        Prostaglandin 2 biosynthesis and metabolism FM


    1 GeneGo (Thomson Reuters) Pathway for CBR3
        Prostaglandin 2 biosynthesis and metabolism FM

    2 PharmGKB Pathways for CBR3
        Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics

    2         Kegg Pathways  (Kegg details for CBR3):
        Arachidonic acid metabolism
    Metabolic pathways


    CBR3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CBR3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/23 Interacting proteins for CBR3 (O758282, 3 ENSP000002903544) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARIH2O953762, 3MINT-63289 I2D: score=5 
    RAB35Q152862, 3MINT-64229 I2D: score=5 
    USP3Q9Y6I43, ENSP000003696814I2D: score=2 STRING: ENSP00000369681
    SGK1O001413, ENSP000003568324I2D: score=1 STRING: ENSP00000356832
    GABARAPO951663I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042376phylloquinone catabolic process IEA--


    CBR3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CBR3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CBR3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CBR3

    9 HMDB Compounds for CBR3    About this table
    CompoundSynonyms CAS #PubMed Ids
    10,11-dihydro-12-oxo-LTB412-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoic acid anion (see all 4)----
    10,11-dihydro-leukotriene B410,11-dihydro-LTB(,4) (see all 6)----
    12-Oxo-20-carboxy-leukotriene B412-oxo-20-COOH-leukotriene B(,4) (see all 5)----
    12-oxo-10,11-dihydro-20-COOH-LTB412-oxo-10,11-dihydro-20-carboxy-LTB(,4) (see all 3)----
    20-COOH-10,11-dihydro-LTB410,11-dihydro-20-COOH-leukotriene B(,4);20-carboxy-10,11-dihydro-LTB(,4);(5S,12R)-dihydroxy-(6Z,8E,14Z)-eicosatrien-1,20-dicarboxylic acid anion ----
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Prostaglandin E2(-)-Prostaglandin E2 (see all 22)363-24-6--
    Prostaglandin F2aProtamodin (see all 37)551-11-1--
    2 Novoseek chemical compound relationships for CBR3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 49.1 8 18983987 (2), 19061875 (1)
    atp 2.53 1 15606508 (1)

    2 PharmGKB related drug/compound annotations for CBR3 gene
    Drug/compound PharmGKB Annotation
    anthracyclines and related substancesCA  
    doxorubicinCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about CBR3 

    Transcripts
    for CBR3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CBR3 gene: 
    NM_001236.3  

    Unigene Cluster for CBR3:

    Carbonyl reductase 3
    Hs.154510  [show with all ESTs]
    Unigene Representative Sequence: AB041012
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000290354(uc002yve.3)

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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CBR3 (see all 7)
    OriGene shRNA RFP: CBR3
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    Clone
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    Additional cDNA sequence: 

    AB004850.1 AB004854.1 AB041012.1 AB124847.1 AJ000095.1 AJ000096.1 AK223429.1 BC002812.2 
    CR541709.1 

    3 DOTS entries:

    DT.429473  DT.121132730  DT.435430 

    24/55 AceView cDNA sequences (see all 55):

    AB004854 AI352345 CN479593 AB004850 AA071157 CB159246 BI084483 BV184417 
    AW383666 BG714047 BI083816 BU150098 BV197248 BE408293 AI652553 AI375520 
    AW383669 CR541709 NM_001236 AA070863 BM762172 AI658832 AW450998 BV206129 

    GeneLoc Exon Structure


    Expression
    for CBR3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CBR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAAAGTTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CBR3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CBR3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CBR3

    SOURCE GeneReport for Unigene cluster: Hs.154510

    UniProtKB/Swiss-Prot: CBR3_HUMAN, O75828
    Tissue specificity: Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen,
    leukocyte, prostate and testis

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    In Situ
    Assay Products:     
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    Orthologs
    for CBR3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CBR3 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cbr31 , 5 carbonyl reductase 31, 5 83.75(n)1
    85.2(a)1    		   16 (54.58 cM)5
    1098571  NM_173047.31  NP_766635.11 
     936832155 
    chicken
    (Gallus gallus)    		 Aves F1P2X1_CHICK6
    		 carbonyl reductase 1
    		 66(a)
    		 1 → many
    		 1(110028120-110033816)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 65(a)
    		 1 → many
    		 GL344111.1(5462-10687)
    zebrafish
    (Danio rerio)    		 Actinopterygii cbr16
    cbr1l6
    		 carbonyl reductase 1-like
    		 56(a)
    53(a)
    		 many → 1
    possible ortholog
    		 1(47662949-47670284)
    21(20520407-20528388)
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 45(a)
    		 1 → many
    		 Group10.17(73535-74683)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G597101 Rossmann-fold NAD(P)-binding domain-containing protein 46.28(n)
    38.84(a)    		   825140  NM_115833.2  NP_191530.1 
    rice
    (Oryza sativa)    		 Liliopsida Os02g06077001 hypothetical protein 51.82(n)
    46.15(a)    		   4329932  NM_001053918.1  NP_001047383.1 


    ENSEMBL Gene Tree for CBR3 (if available)
    TreeFam Gene Tree for CBR3 (if available) 

    Paralogs
    for CBR3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CBR3 gene
    CBR12  
    1 SIMAP similar gene for CBR3 using alignment to 1 protein entry:     CBR3_HUMAN:
    CBR1

    CBR3 for paralogs           About GeneDecksing



    Genomic Variants
    for CBR3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/321 NCBI SNPs in CBR3 are shown (see all 321)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1450568281,2
    		--37505316(+) ATGACA/GAGGAG 3 -- nc-transcript-variantus2k10--------
    rs1869203271,2
    		--37505325(+) AGGAGA/GAATAA 3 -- nc-transcript-variantus2k10--------
    rs1922276131,2
    		--37505423(+) AATTAA/TGAAAA 3 -- int1 us2k10--------
    rs1417654071,2
    		--37505464(+) GGCCAA/GGCACG 3 -- int1 us2k10--------
    rs1147256481,2
    		C,F,--37505468(+) AGGCAC/TGGTGA 3 -- int1 us2k11Minor allele frequency- T:0.05WA 118
    rs603768981,2
    		C,F,--37505704(+) ACCAGC/ACTGGC 3 -- us2k1 int12Minor allele frequency- A:0.50NA WA 4
    rs600431021,2
    		C,F,--37505827(+) AGGATG/TCGGAG 3 -- us2k1 int13Minor allele frequency- T:0.50WA NA 6
    rs788413121,2
    		C--37505922(+) AATTAC/TCCAGG 3 -- us2k1 int10--------
    rs670132311,2
    		C,F,--37506102(+) TAGAAA/CGCCTA 3 -- int1 us2k18Minor allele frequency- C:0.36NA WA EA 368
    rs357823961,2
    		C--37506146(+) TTTTTT/-GAAAA 3 -- int1 us2k11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for CBR3 (37507210 - 37518864 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for CBR3
         5 CNVs: 8894 8893 50772 34484 7322
         1 Indel: 26958
    Human Gene Mutation Database (HGMD): CBR3

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    Disorders / Diseases
    for CBR3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CBR3 for disorders           About GeneDecksing

    OMIM gene information: 603608    OMIM disorders: --

    11 diseases for CBR3:    About MalaCards
    congestive heart failure    epithelial ovarian cancer    alcoholism    down syndrome
    keloids    ovarian cancer    parkinson's disease    pulmonary disease
    breast cancer    hepatitis    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: CBR3 (9 documents)

    Export disorders for CBR3 gene to outside databases

    Publications
    for CBR3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CBR3 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with CBR3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2. (PubMed id 9740676)1, 2, 3, 9 Watanabe K.... Nomura T. (1998)
    2. Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1. (PubMed id 18493841)1, 2, 9 Miura T....Terada T. (2008)
    3. Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3). (PubMed id 15537833)1, 2, 9 Lakhman S.S.... Blanco J.G. (2005)
    4. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    7. Structural basis for substrate specificity in human m onomeric carbonyl reductases. (PubMed id 19841672)1, 9 Pilka E.S....Oppermann U. (2009)
    8. CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients. (PubMed id 19016765)1, 9 Lal S....Chowbay B. (2008)
    9. Identification of the promoter of human carbonyl redu ctase 3 (CBR3) and impact of common promoter polymorphisms on hepatic CBR3 mRNA expression. (PubMed id 19590938)1, 9 Zhang J. and Blanco J.G. (2009)
    10. Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer. (PubMed id 18457324)1, 9 Blanco J.G....Bhatia S. (2008)

    External Searches for CBR3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing CBR3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 874 HGNC: 1549 AceView: CBR3 Ensembl:ENSG00000159231 euGenes: HUgn874
    ECgene: CBR3 Kegg: 874 H-InvDB: CBR3

    Other Databases showing CBR3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CBR3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CBR3 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/cbr3/

    Intellectual Property
    for CBR3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CBR3 gene:
    Search GeneIP for patents involving CBR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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