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Aliases for CBR3 Gene

Aliases for CBR3 Gene

  • Carbonyl Reductase 3 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 21C Member 2 3 4
  • NADPH-Dependent Carbonyl Reductase 3 3 4
  • EC 1.1.1.184 4 63
  • Short Chain Dehydrogenase/Reductase Family 21C, Member 2 3
  • Short Chain Dehydrogenase/Reductase Family 21C 2
  • Epididymis Secretory Protein Li 25 3
  • Carbonyl Reductase (NADPH) 3 3
  • Member 2 2
  • HEL-S-25 3
  • EC 1.1.1 63
  • SDR21C2 3
  • HCBR3 3

External Ids for CBR3 Gene

Previous GeneCards Identifiers for CBR3 Gene

  • GC21P034084
  • GC21P034167
  • GC21P036427
  • GC21P036429
  • GC21P037507
  • GC21P022984

Summaries for CBR3 Gene

Entrez Gene Summary for CBR3 Gene

  • Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]

GeneCards Summary for CBR3 Gene

CBR3 (Carbonyl Reductase 3) is a Protein Coding gene. Among its related pathways are Linoleic acid metabolism and Metabolism. GO annotations related to this gene include oxidoreductase activity and carbonyl reductase (NADPH) activity. An important paralog of this gene is CBR1.

UniProtKB/Swiss-Prot for CBR3 Gene

  • Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro).

Gene Wiki entry for CBR3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBR3 Gene

Genomics for CBR3 Gene

Regulatory Elements for CBR3 Gene

Enhancers for CBR3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CBR3 on UCSC Golden Path with GeneCards custom track

Promoters for CBR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CBR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CBR3 Gene

Chromosome:
21
Start:
36,134,900 bp from pter
End:
36,146,566 bp from pter
Size:
11,667 bases
Orientation:
Plus strand

Genomic View for CBR3 Gene

Genes around CBR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBR3 Gene

Proteins for CBR3 Gene

  • Protein details for CBR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75828-CBR3_HUMAN
    Recommended name:
    Carbonyl reductase [NADPH] 3
    Protein Accession:
    O75828
    Secondary Accessions:
    • Q6FHP2

    Protein attributes for CBR3 Gene

    Size:
    277 amino acids
    Molecular mass:
    30850 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CBR3 Gene

neXtProt entry for CBR3 Gene

Proteomics data for CBR3 Gene at MOPED

Selected DME Specific Peptides for CBR3 Gene

Post-translational modifications for CBR3 Gene

  • Ubiquitination at Lys 112
  • Modification sites at PhosphoSitePlus

Other Protein References for CBR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CBR3 Gene

Gene Families for CBR3 Gene

Suggested Antigen Peptide Sequences for CBR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75828

UniProtKB/Swiss-Prot:

CBR3_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with CBR3: view

Function for CBR3 Gene

Molecular function for CBR3 Gene

GENATLAS Biochemistry:
carbonyl reductase,NADPH-dependent oxidoreductase
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=25 uM for menadione {ECO:0000269 PubMed:15537833, ECO:0000269 PubMed:18493841}; KM=43 uM for menadione {ECO:0000269 PubMed:15537833, ECO:0000269 PubMed:18493841}; KM=90 uM for NADPH {ECO:0000269 PubMed:15537833, ECO:0000269 PubMed:18493841}; KM=38 uM for NADPH {ECO:0000269 PubMed:15537833, ECO:0000269 PubMed:18493841}; pH dependence: Optimum pH is 5.5-7. {ECO:0000269 PubMed:15537833, ECO:0000269 PubMed:18493841};
UniProtKB/Swiss-Prot CatalyticActivity:
R-CHOH-R + NADP(+) = R-CO-R + NADPH.
UniProtKB/Swiss-Prot Function:
Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro).

Enzyme Numbers (IUBMB) for CBR3 Gene

genes like me logo Genes that share phenotypes with CBR3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CBR3

miRNA for CBR3 Gene

miRTarBase miRNAs that target CBR3

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBR3 Gene

Localization for CBR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBR3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBR3 Gene COMPARTMENTS Subcellular localization image for CBR3 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CBR3 Gene

Pathways & Interactions for CBR3 Gene

genes like me logo Genes that share pathways with CBR3: view

Gene Ontology (GO) - Biological Process for CBR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with CBR3: view

No data available for SIGNOR curated interactions for CBR3 Gene

Drugs & Compounds for CBR3 Gene

(6) Drugs for CBR3 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxorubicin Approved, Investigational Pharma Enzyme, substrate Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1649
Doxil Approved June 1999 Pharma DNA intercalator and TOPO II inhibitor, Topoisomerase 2 Inhibitors 1649
Dinoprostone Approved Pharma Major endogenous prostanoid 78
anthracyclines and related substances Pharma 0

(6) Additional Compounds for CBR3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
  • NNAL
76014-81-8
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
  • 4-(Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
  • 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
  • 4-(Methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
  • 4-(Methylnitrosoamino)-1-(3-pyridyl)-1-butanone
  • 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
64091-91-4
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with CBR3: view

Transcripts for CBR3 Gene

mRNA/cDNA for CBR3 Gene

Unigene Clusters for CBR3 Gene

Carbonyl reductase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CBR3 Gene

No ASD Table

Relevant External Links for CBR3 Gene

GeneLoc Exon Structure for
CBR3
ECgene alternative splicing isoforms for
CBR3

Expression for CBR3 Gene

mRNA expression in normal human tissues for CBR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CBR3 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.3).

Protein differential expression in normal tissues from HIPED for CBR3 Gene

This gene is overexpressed in Oral epithelium (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CBR3 Gene



SOURCE GeneReport for Unigene cluster for CBR3 Gene Hs.154510

mRNA Expression by UniProt/SwissProt for CBR3 Gene

O75828-CBR3_HUMAN
Tissue specificity: Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis.
genes like me logo Genes that share expression patterns with CBR3: view

Protein tissue co-expression partners for CBR3 Gene

Primer Products

In Situ Assay Products

Orthologs for CBR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CBR3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CBR3 35
  • 85.8 (n)
  • 85.92 (a)
CBR3 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CBR3 35
  • 88.57 (n)
  • 87 (a)
CBR3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cbr3 35
  • 83.75 (n)
  • 85.2 (a)
Cbr3 16
Cbr3 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CBR3 35
  • 99.4 (n)
  • 99.64 (a)
CBR3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cbr3 35
  • 83.75 (n)
  • 84.84 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves CBR1 36
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii cbr1 36
  • 56 (a)
OneToMany
Species with no ortholog for CBR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBR3 Gene

ENSEMBL:
Gene Tree for CBR3 (if available)
TreeFam:
Gene Tree for CBR3 (if available)

Paralogs for CBR3 Gene

Paralogs for CBR3 Gene

(1) SIMAP similar genes for CBR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CBR3: view

Variants for CBR3 Gene

Sequence variations from dbSNP and Humsavar for CBR3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
VAR_033868 -
VAR_033869 -
VAR_033870 -
VAR_033871 -
VAR_033872 -

Structural Variations from Database of Genomic Variants (DGV) for CBR3 Gene

Variant ID Type Subtype PubMed ID
esv2751927 CNV Gain 17911159
esv2751928 CNV Gain 17911159
esv33578 CNV Loss 17666407
nsv459249 CNV Gain 19166990
nsv913733 CNV Loss 21882294
nsv516175 CNV Gain 19592680
esv1434184 CNV Deletion 17803354

Variation tolerance for CBR3 Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.22; 98.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CBR3 Gene

HapMap Linkage Disequilibrium report
CBR3
Human Gene Mutation Database (HGMD)
CBR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBR3 Gene

Disorders for CBR3 Gene

Relevant External Links for CBR3

Genetic Association Database (GAD)
CBR3
Human Genome Epidemiology (HuGE) Navigator
CBR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBR3

No disorders were found for CBR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBR3 Gene

Publications for CBR3 Gene

  1. Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2. (PMID: 9740676) Watanabe K. … Nomura T. (Genomics 1998) 2 3 4 23 67
  2. Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism. (PMID: 20007405) Bains O.S. … Riggs K.W. (J. Pharmacol. Exp. Ther. 2010) 23 25
  3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  4. Structural basis for substrate specificity in human monomeric carbonyl reductases. (PMID: 19841672) Pilka E.S. … Oppermann U. (PLoS ONE 2009) 3 23
  5. Identification of the promoter of human carbonyl reductase 3 (CBR3) and impact of common promoter polymorphisms on hepatic CBR3 mRNA expression. (PMID: 19590938) Zhang J. … Blanco J.G. (Pharm. Res. 2009) 3 23

Products for CBR3 Gene

Sources for CBR3 Gene

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