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CBR3 Gene

protein-coding   GIFtS: 63

GC21P036429
carbonyl reductase 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase, and/or 9Nature:405,311-319 and CroW21)
About This Section

Aliases
EC 1.1.1.184 3
SDR21C2 1, 2
hCBR3 2
Descriptions
NADPH-dependent carbonyl reductase 3 2, 3
carbonyl reductase (NADPH) 3 2
carbonyl reductase (NADPH) 3, EC 1.1.1.184 9
carbonyl reductase 3 2
short chain dehydrogenase/reductase family 21C, member 2 2
External Ids
HGNC: 15491
Entrez Gene: 8742
UniProtKB: O758283
Ensembl: ENSG000001592317
Search outside databases for aliases for CBR3 gene

Previous GC identifers: GC21P034084 GC21P034167 GC21P036427

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for CBR3:
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and
pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is
classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2
kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq]

Gene Wiki entry for CBR3
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.2   Ensembl cytogenetic band:  21q22.12   HGNC cytogenetic band: 21q22.2
Nature(405: 311-319) cytogenetic band:   21q22.13
CBR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P036429:   GeneLoc Nature:405,311-319
Start:
36,429,133 bp from pter       23,084,242 bp from centromere
End:
36,440,730 bp from pter 23,095,605 bp from centromere
Size:
11,598 bases 11,364 bases
Orientation:
plus strand plus strand
RefSeq DNA sequence:
NC_000021.7  NT_011512.10  

Whole chromosome sequencing:
cDNA sequence: AB004854
genomic clones: KB795B7

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CBR3_HUMAN, O75828 (See protein sequence)
Recommended Name: Carbonyl reductase [NADPH] 3  
Size: 277 amino acids; 30850 Da
Subcellular location: Cytoplasm (Potential)
PDB structures from and Proteopedia :
2HRB (3D)    
Secondary accessions: Q6FHP2

REFSEQ proteins: NP_001227.1  

ENSEMBL proteins: 
ENSP00000290354 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (CBR3)
Human Recombinant Proteins from Abnova (CBR3)
              OriGene Purified Recombinant Human Protein: CBR3 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IEA--
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Antibodies for CBR3: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for CBR3
Browse R&D Systems for Antibodies
Antibodies from Abcam (CBR3), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (CBR3)
Novus Biologicals Antibodies for CBR3

Assays for CBR3: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro domains/families:
 IPR002347 Glc/ribitol_DH
 IPR002198 DH_sc/Rdtase_SDR
 IPR016040 NAD(P)-bd_dom


   GeneDecks  CBR3 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry O75828

ProtoNet protein and cluster: O75828

2 Blocks protein families:
IPB002198 Short-chain dehydrogenase/reductase SDR
IPB002347 Glucose/ribitol dehydrogenase family signature


UniProtKB/Swiss-Prot: CBR3_HUMAN, O75828
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (CBR3)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (CBR3)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC002812

              Applied Biosystems Silencer® siRNAs for CBR3

              Sigma-Aldrich siRNA and siRNA Panels for CBR3  
                     Sigma-Aldrich shRNA for CBR3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for CBR3
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001236
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001236
                                 untagged cDNA clones in CMV expression vector (see all 2): BC002812 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001236

UniProtKB/Swiss-Prot: CBR3_HUMAN, O75828
Catalytic activity: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH
Enzyme Number (IUBMB): EC 1.1.1.184 

Genatlas biochemistry entry for CBR3:
carbonyl reductase,NADPH-dependent oxidoreductase

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004090 carbonyl reductase (NADPH) activity TAS9740676
GO:0005488 binding IEA--
GO:0016491 oxidoreductase activity IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


1 Millipore Pathway for CBR3
 Prostaglandin 2 biosynthesis and metabolism FM

   GeneDecks  CBR3 for the pathways selected above  
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for  CBR3  (Your Favorite Gene powered by Ingenuity) 
 Arachidonic Acid Metabolism
 Inositol Metabolism

   GeneDecks  CBR3 for the pathways selected above  
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1 Kegg Pathway  (Kegg details for CBR3):
 hsa00590 Arachidonic acid metabolism

   GeneDecks  CBR3 for the pathways selected above  
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5/6 Interacting proteins for CBR3 (O758282 ENSP000002903543) via UniProtKB, MINT, and/or STRING (see all 6 )
InteractantInteraction Details
GeneCardExternal ID(s)
ARIH2O953762MINT-63289
RAB35Q152862MINT-64229
PTGESENSP000003423853STRING (score=.899)
PTGES2ENSP000003453413STRING (score=.899)
CBR1ENSP000002903493STRING (score=.81)
About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0055114 oxidation reduction IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CBR3
2 Novoseek chemical compound relationships for CBR3 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
proline 53.53 8 18983987 (2), 19061875 (1)
atp 8.28 1 15606508 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (CBR3)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (CBR3)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC002812

              Sigma-Aldrich siRNA and siRNA Panels for CBR3  
                     Sigma-Aldrich shRNA for CBR3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001236  

REFSEQ mRNAs for CBR3 gene: 

NM_001236.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001236  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001236
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001236
                                 untagged cDNA clones in CMV expression vector (see all 2): BC002812 

Additional cDNA sequence: 

AB004850.1 AB004854.1 AB041012.1 AB124847.1 AJ000095.1 AJ000096.1 AK223429.1 BC002812.2 
CR541709.1 

2 DOTS entries:

DT.429473  DT.121132730 

24/55 AceView cDNA sequences (see all 55 ):

AB004854 BI084483 AB004850 AA071157 AI352345 CB159246 CN479593 AI658832 
BU150098 AW383669 BM763268 BE408293 BV206129 BG714047 BG165774 BV184417 
AW450998 AI652553 CR541709 AA070863 BQ440869 BM762172 AI375520 BM765037 

highest scoring ESTs for CBR3:

AA070863 AA320697 AA887663 AB004854 AI352345 AI375520 AI652553 AI658832 AI686685 AW371669 

Unigene Cluster for CBR3:

Carbonyl reductase 3
Hs.154510  [show with all ESTs]
Unigene Representative Sequence: AB041012


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000290354  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CBR3 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for CBR3

1 / 2 / 3

3 probe-sets matching CBR3 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

38172_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB003151 0.20 0.50 0.38 1

205379_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001236 0.60 1.00 0.82 1

205379_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: ACAAAGTTGT

SOURCE GeneReport for Unigene cluster: Hs.154510

Expression variation in blood from EXPOLDB for CBR3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for CBR3 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
CBR31   -- carbonyl reductase 3 88.57(n)
87(a)
487748  XM_544873.2  XP_544873.2 
chimpanzee
(Pan troglodytes)
CBR31   -- carbonyl reductase 3 99.4(n)
99.64(a)
458533  XM_514884.2  XP_514884.2 
cow
(Bos taurus)
CBR31   -- carbonyl reductase 3 85.8(n)
85.92(a)
516036  NM_001075734.1  NP_001069202.1 
rat
(Rattus norvegicus)
Cbr31   -- carbonyl reductase 3 83.75(n)
84.84(a)
304078  XM_221641.4  XP_221641.4 
mouse
(Mus musculus)
Cbr31, 5 16 (67.20 cM)5
carbonyl reductase 31, 5 83.75(n)1
85.2(a)1
1098571  NM_173047.21  NP_766635.11 
 AI3248015  AK0032325  (see all 12)
About this table        Species with no ortholog for CBR3

ENSEMBL Gene Tree for CBR3
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for CBR3 gene
CBR12  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/185 NCBI SNPs in CBR3 are shown (see all 185 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 38)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 21 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs81330521,2
A,C,F,H36429371(+) GTCCTG/ACAGCC 1 Y/C mis1 ese310Minor allele frequency- A:0.41NA EU EA WA NS 690
rs10568921,2
A,C,F,H36440576(+) GGACTG/ATGGAG 1 M/V mis1 ese326Minor allele frequency- A:0.37NA EA MN EU WA CSAM NS 2202
--
rs28352851,2
C,F,H,O36429637(+) CGGCCG/ATYGCC 1 I/V mis1 ese310Minor allele frequency- A:0.01NA MN CSAM EA EU WA 827
rs49871211,2
C,F,H36440549(+) CAGACA/TTGGAT 1 M/L mis1 ese319Minor allele frequency- T:0.01MN CSAM EA EU WA NS 1746
rs22395661,2
C,F,H36428636(+) GAGAAT/CATATG 1 -- ng51 tfbs310Minor allele frequency- C:0.16NA EA EU WA NS 2248
rs169939291,2
C,F,H36432094(+) TGAAAC/TCTCAT 1 P/S mis1 ese314Minor allele frequency- T:0.05NA EU EA WA NS 1118
--
rs92826281,2
C,F36429610(+) GGGGGC/GTCAAT 1 L/V mis17Minor allele frequency- G:0.03MN CSAM EA NS 484
--
rs81322431,2
C,F36429035(+) TGCCAT/AGAATC 1 -- ng512Minor allele frequency- A:0.09NS 82
--
rs349113621,2
C,F36440720(+) TGGTGG/AAATGA 1 -- ut312Minor allele frequency- A:0.05NS 94
--
rs350829471,2
C,F36441213(+) CCTCCT/CGAGCA 1 -- ng312Minor allele frequency- C:0.06NS 88
About this table

HapMap Linkage Disequilibrium images for CBR3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603608

Human Gene Mutation Database: CBR3
Human Genome Epidemiology Navigator: CBR3 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/26 PubMed articles for CBR3 gene (see all 26 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 874 HGNC: 1549 AceView: CBR3 Ensembl:ENSG00000159231 euGenes: HUgn874
ECgene: CBR3 H-InvDB: CBR3
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
SeattleSNPshttp://pga.gs.washington.edu/data/cbr3/
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for CBR3:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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  Invitrogen Antibodies  Invitrogen Assays
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 Predesigned and custom siRNAs for CBR3 Antibodies for CBR3
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for CBR3 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Custom Service for Rabbit Pab from Full-length Protein
  
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 Recombinant Proteins
(CBR3)
 Antibodies (CBR3)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for CBR3




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for CBR3

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