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Aliases & Descriptions for CBR3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase, and/or 9Nature:405,311-319 and CroW21) About This Section
|
| Aliases |
|---|
| EC 1.1.1.184 3 | | SDR21C2 1, 2 | | hCBR3 2 |
| | | Descriptions |
|---|
| NADPH-dependent carbonyl reductase 3 2, 3 | | carbonyl reductase (NADPH) 3 2 | | carbonyl reductase (NADPH) 3, EC 1.1.1.184 9 | | carbonyl reductase 3 2 | | short chain dehydrogenase/reductase family 21C, member 2 2 |
|
| | Search outside databases for aliases for CBR3 genePrevious GC identifers: GC21P034084 GC21P034167 GC21P036427 |
Summaries for CBR3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for CBR3: Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq] Gene Wiki entry for CBR3 |
Genomic Location for CBR3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences, Whole Chromsome Sequence According to
Nature (Cited Here with Permission):405,311-319 and CroW21) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21q22.2 Ensembl cytogenetic band: 21q22.12 HGNC cytogenetic band: 21q22.2 Nature(405: 311-319) cytogenetic band: 21q22.13 | CBR3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 |
| GC21P036429: |
GeneLoc |
Nature:405,311-319 |
Start:
|
36,429,133 bp from pter |
23,084,242 bp from centromere |
End:
|
36,440,730 bp from pter |
23,095,605 bp from centromere |
Size:
|
11,598 bases |
11,364 bases |
Orientation:
|
plus strand |
plus strand |
RefSeq DNA sequence:- NC_000021.7 NT_011512.10
| Whole chromosome sequencing: |
| cDNA sequence: |
AB004854 | | genomic clones: |
KB795B7 |
Proteins for CBR3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: CBR3_HUMAN, O75828 (See
protein sequence)Recommended Name: Carbonyl reductase [NADPH] 3 Size: 277 amino acids; 30850 Da
Subcellular location: Cytoplasm (Potential)
PDB structures from and Proteopedia :2HRB (3D)
 
Secondary accessions: Q6FHP2REFSEQ proteins: NP_001227.1
ENSEMBL proteins: ENSP00000290354
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: CBR3 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | About this table
Antibodies for CBR3: Assays for CBR3: | Protein
Domains/ Families for CBR3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O75828
ProtoNet protein and cluster: O75828 2 Blocks protein families: IPB002198 Short-chain dehydrogenase/reductase SDR IPB002347 Glucose/ribitol dehydrogenase family signature
UniProtKB/Swiss-Prot: CBR3_HUMAN, O75828Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family | Gene Function for CBR3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC002812
Applied Biosystems Silencer® siRNAs for CBR3
Sigma-Aldrich siRNA and siRNA Panels for CBR3  Sigma-Aldrich shRNA for CBR3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001236                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001236                                  untagged cDNA clones in CMV expression vector (see all 2): BC002812 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001236
UniProtKB/Swiss-Prot: CBR3_HUMAN, O75828Catalytic activity: R-CHOH-R' + NADP(+) = R-CO-R' + NADPHEnzyme Number (IUBMB): EC 1.1.1.184 Genatlas biochemistry entry for CBR3:carbonyl reductase,NADPH-dependent oxidoreductase3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for CBR3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for CBR3 (Your Favorite Gene powered by Ingenuity) 
5/6 Interacting proteins for CBR3 (O758282 ENSP000002903543) via UniProtKB, MINT, and/or STRING (see all 6
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0055114 | oxidation reduction |
IEA | -- | About this table
|
Drugs & Compounds for CBR3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for CBR3 2 Novoseek chemical compound relationships for CBR3 gene
About this table
|
Transcripts for CBR3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC002812
Sigma-Aldrich siRNA and siRNA Panels for CBR3  Sigma-Aldrich shRNA for CBR3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001236 REFSEQ mRNAs for CBR3 gene: NM_001236.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001236               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001236                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001236                                  untagged cDNA clones in CMV expression vector (see all 2): BC002812  Additional cDNA sequence: AB004850.1 AB004854.1 AB041012.1 AB124847.1 AJ000095.1 AJ000096.1 AK223429.1 BC002812.2 CR541709.1 2 DOTS entries: DT.429473 DT.121132730 24/55 AceView cDNA sequences (see all 55
):AB004854 BI084483 AB004850 AA071157 AI352345 CB159246 CN479593 AI658832 BU150098 AW383669 BM763268 BE408293 BV206129 BG714047 BG165774 BV184417 AW450998 AI652553 CR541709 AA070863 BQ440869 BM762172 AI375520 BM765037
highest scoring ESTs for CBR3:AA070863 AA320697 AA887663 AB004854 AI352345 AI375520 AI652553 AI658832 AI686685 AW371669 Unigene Cluster for CBR3: Carbonyl reductase 3 Hs.154510 [show with all ESTs]Unigene Representative Sequence: AB041012
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000290354
|
Expression for CBR3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| CBR3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for CBR3
1 / 2 / 3 3 probe-sets matching CBR3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACAAAGTTGT
SOURCE GeneReport for Unigene cluster: Hs.154510
Expression variation in blood from EXPOLDB for CBR3 |
Orthologs for CBR3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CBR3 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for CBR3
ENSEMBL Gene Tree for CBR3 | Paralogs for CBR3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for CBR3 gene
- CBR12
|
SNPs/Variants for CBR3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for CBR3 (up to first 250kb)
|
Disorders & Mutations for CBR3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603608
Human Gene Mutation Database: CBR3 Human Genome Epidemiology Navigator: CBR3 (4 documents)
|
Medical News for CBR3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for CBR3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/26 PubMed articles for CBR3 gene (see all 26
):- Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2. (PubMed id 9740676)1, 2, 3, 4 Watanabe K.... Nomura T. (1998)
- The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)2, 3 Persson B....Oppermann U. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 21. (PubMed id 10830953)3, 4 Hattori M....Yaspo M.L. (2000)
- Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1. (PubMed id 18493841)1, 3 Miura T....Terada T. (2008)
- Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3). (PubMed id 15537833)1, 3 Lakhman S.S....Blanco J.G. (2005)
- CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients. (PubMed id 19016765)1, 3 Lal S....Chowbay B. (2008)
- Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer. (PubMed id 18457324)1, 3 Blanco J.G....Bhatia S. (2008)
- Genotype of human carbonyl reductase CBR3 correlates with doxorubicin disposition and toxicity. (PubMed id 18551042)3 Fan L....Lee S.C. (2008)
- Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)3 Hosgood H.D....Lan Q. (2008)
|
Search for CBR3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CBR3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing CBR3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CBR3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| SeattleSNPs | http://pga.gs.washington.edu/data/cbr3/ |
|
| | | About This Section
| --
| Services for CBR3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for CBR3:

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