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CBR3 Gene(Protein Coding)

Carbonyl Reductase 3

GCID:
GC21P036134
GIFtS:
63
Genes Participants
UDN Logo

Aliases for CBR3 Gene

Aliases for CBR3 Gene

  • Carbonyl Reductase 3 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 21C Member 2 3 4
  • NADPH-Dependent Carbonyl Reductase 3 3 4
  • EC 1.1.1.184 4 61
  • Short Chain Dehydrogenase/Reductase Family 21C, Member 2 2
  • Epididymis Secretory Protein Li 25 3
  • Carbonyl Reductase (NADPH) 3 3
  • Carbonyl Reductase [NADPH] 3 3
  • HEL-S-25 3
  • EC 1.1.1 61
  • SDR21C2 3
  • HCBR3 3

External Ids for CBR3 Gene

Previous GeneCards Identifiers for CBR3 Gene

  • GC21P034084
  • GC21P034167
  • GC21P036427
  • GC21P036429
  • GC21P037507
  • GC21P022984

Summaries for CBR3 Gene

Entrez Gene Summary for CBR3 Gene

  • Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]

GeneCards Summary for CBR3 Gene

CBR3 (Carbonyl Reductase 3) is a Protein Coding gene. Among its related pathways are Doxorubicin Pathway, Pharmacokinetics and NRF2 pathway. GO annotations related to this gene include oxidoreductase activity and carbonyl reductase (NADPH) activity. An important paralog of this gene is CBR1.

UniProtKB/Swiss-Prot for CBR3 Gene

  • Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro).

Gene Wiki entry for CBR3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBR3 Gene

Genomics for CBR3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CBR3 Gene

Enhancers for CBR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G036112 1.9 FANTOM5 Ensembl ENCODE dbSUPER 20.2 -21.2 -21171 2.7 PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 DOPEY2 CBR3 SETD4 LOC105369295 TTC3 LOC105369306 LOC100133286
GH21G036155 1.6 FANTOM5 ENCODE dbSUPER 12.5 +21.6 21607 2.6 HDGF PKNOX1 AGO1 SIN3A YY1 ZNF207 SP3 ZNF662 SREBF1 ZNF610 DOPEY2 SETD4 RIMKLBP1 CBR3 LOC100133286 CBR1 GC21P036137
GH21G036141 1.5 Ensembl ENCODE dbSUPER 12.9 +6.8 6782 1.2 PKNOX1 FOXA2 ARID4B SIN3A YY1 ZNF143 FOS DEK ZNF263 SP3 DOPEY2 CBR3 MORC3 GC21P036137
GH21G036162 1.5 Ensembl ENCODE dbSUPER 12.2 +28.9 28921 1.9 ATF1 FOXA2 MLX CREB3L1 ARID4B CBX5 KLF13 SP5 NCOA1 MXD4 DOPEY2 CBR3 RPL3P1
GH21G036133 1.3 ENCODE dbSUPER 12.8 +0.5 497 2.9 HDGF SIN3A GLI4 ZNF2 ZNF121 GLIS2 ZNF416 KLF7 ZNF548 SP3 DOPEY2 MORC3 CBR3 RPL23AP3 SETD4 CBR1 ENSG00000228107 GC21P036137
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CBR3 on UCSC Golden Path with GeneCards custom track

Promoters for CBR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000141986 700 1601 HDGF GLI4 ZNF2 ZNF121 GLIS2 ZNF416 KLF7 ZNF548 SP3 REST

Transcription factor binding sites by QIAGEN in the CBR3 gene promoter:

Genomic Location for CBR3 Gene

Chromosome:
21
Start:
36,134,900 bp from pter
End:
36,146,566 bp from pter
Size:
11,667 bases
Orientation:
Plus strand

Genomic View for CBR3 Gene

Genes around CBR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBR3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CBR3 Gene

Proteins for CBR3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CBR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75828-CBR3_HUMAN
    Recommended name:
    Carbonyl reductase [NADPH] 3
    Protein Accession:
    O75828
    Secondary Accessions:
    • Q6FHP2

    Protein attributes for CBR3 Gene

    Size:
    277 amino acids
    Molecular mass:
    30850 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CBR3 Gene

neXtProt entry for CBR3 Gene

Protein Expression for CBR3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CBR3 Gene

O75828:
  • GRVVNISS
  • KFVEDTK
  • QSIRALRDFL
  • AAVQQLQAEGLSP

Post-translational modifications for CBR3 Gene

  • Ubiquitination at Lys112
  • Modification sites at PhosphoSitePlus

Other Protein References for CBR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CBR3

Domains & Families for CBR3 Gene

Gene Families for CBR3 Gene

HGNC:

Protein Domains for CBR3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CBR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75828

UniProtKB/Swiss-Prot:

CBR3_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with CBR3: view

Function for CBR3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CBR3 Gene

GENATLAS Biochemistry:
carbonyl reductase,NADPH-dependent oxidoreductase
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=25 uM for menadione {ECO:0000269 PubMed:15537833, ECO:0000269 PubMed:18493841}; KM=43 uM for menadione {ECO:0000269 PubMed:15537833, ECO:0000269 PubMed:18493841}; KM=90 uM for NADPH {ECO:0000269 PubMed:15537833, ECO:0000269 PubMed:18493841}; KM=38 uM for NADPH {ECO:0000269 PubMed:15537833, ECO:0000269 PubMed:18493841}; pH dependence: Optimum pH is 5.5-7. {ECO:0000269 PubMed:15537833, ECO:0000269 PubMed:18493841};
UniProtKB/Swiss-Prot CatalyticActivity:
R-CHOH-R + NADP(+) = R-CO-R + NADPH.
UniProtKB/Swiss-Prot Function:
Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro).

Enzyme Numbers (IUBMB) for CBR3 Gene

Gene Ontology (GO) - Molecular Function for CBR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000253 3-keto sterol reductase activity IEA --
GO:0004090 carbonyl reductase (NADPH) activity TAS --
GO:0005515 protein binding IPI 25910212
GO:0016491 oxidoreductase activity IEA --
GO:0070402 NADPH binding IDA 18493841
genes like me logo Genes that share ontologies with CBR3: view
genes like me logo Genes that share phenotypes with CBR3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CBR3

miRNA for CBR3 Gene

miRTarBase miRNAs that target CBR3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CBR3

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBR3 Gene

Localization for CBR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBR3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CBR3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CBR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CBR3: view

Pathways & Interactions for CBR3 Gene

genes like me logo Genes that share pathways with CBR3: view

Pathways by source for CBR3 Gene

1 BioSystems pathway for CBR3 Gene
1 GeneGo (Thomson Reuters) pathway for CBR3 Gene

Gene Ontology (GO) - Biological Process for CBR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0042376 phylloquinone catabolic process IEA --
GO:0050890 cognition IMP 23227193
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CBR3: view

No data available for SIGNOR curated interactions for CBR3 Gene

Drugs & Compounds for CBR3 Gene

Products:

  1. Drug

(7) Drugs for CBR3 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxorubicin Approved, Investigational Pharma Enzyme, substrate Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1751
Deutetrabenazine Approved, Investigational Pharma Enzyme, substrate 0
Doxil Approved June 1999 Pharma DNA intercalator and TOPO II inhibitor, Topoisomerase 2 Inhibitors 1751
anthracyclines and related substances Pharma 0
Prostaglandin E2 Pharma activates the PGE2 receptor, Major endogenous prostanoid 0

(6) Additional Compounds for CBR3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
  • NNAL
 76014-81-8
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
  • 4-(Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
  • 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
  • 4-(Methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
  • 4-(Methylnitrosoamino)-1-(3-pyridyl)-1-butanone
  • 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
 64091-91-4
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
 53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
 53-57-6
genes like me logo Genes that share compounds with CBR3: view

Transcripts for CBR3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CBR3 Gene

(55) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CBR3 Gene

Carbonyl reductase 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CBR3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CBR3 Gene

No ASD Table

Relevant External Links for CBR3 Gene

GeneLoc Exon Structure for
CBR3
ECgene alternative splicing isoforms for
CBR3

Expression for CBR3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CBR3 Gene

mRNA expression in normal human tissues for CBR3 Gene
mRNA expression by BioGPS for CBR3 GenemRNA expression by GTEx for CBR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CBR3 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.3).

Protein differential expression in normal tissues from HIPED for CBR3 Gene

This gene is overexpressed in Oral epithelium (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CBR3 Gene



Protein tissue co-expression partners for CBR3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CBR3 Gene:

CBR3

SOURCE GeneReport for Unigene cluster for CBR3 Gene:

Hs.154510

mRNA Expression by UniProt/SwissProt for CBR3 Gene:

O75828-CBR3_HUMAN
Tissue specificity: Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis.

Evidence on tissue expression from TISSUES for CBR3 Gene

  • Nervous system(4.1)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with CBR3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CBR3 Gene

Orthologs for CBR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CBR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CBR3 34 35
  • 99.4 (n)
dog
(Canis familiaris)
 Mammalia CBR3 34 35
  • 88.57 (n)
cow
(Bos Taurus)
 Mammalia CBR3 34 35
  • 85.8 (n)
mouse
(Mus musculus)
 Mammalia Cbr3 34 16 35
  • 83.75 (n)
rat
(Rattus norvegicus)
 Mammalia Cbr3 34
  • 83.75 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 67 (a)
 ManyToMany
-- 35
  • 64 (a)
 ManyToMany
-- 35
  • 62 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 63 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves CBR1 35
  • 67 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 67 (a)
 ManyToMany
-- 35
  • 65 (a)
 ManyToMany
zebrafish
(Danio rerio)
 Actinopterygii cbr1 35
  • 56 (a)
 OneToMany
Species where no ortholog for CBR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBR3 Gene

ENSEMBL:
Gene Tree for CBR3 (if available)
TreeFam:
Gene Tree for CBR3 (if available)

Paralogs for CBR3 Gene

Paralogs for CBR3 Gene

(1) SIMAP similar genes for CBR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CBR3: view

Variants for CBR3 Gene

Sequence variations from dbSNP and Humsavar for CBR3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1056892 drug-response 36,146,408(+) GGACT(A/G)TGGAG intron-variant, reference, missense
rs1000526584 -- 36,142,317(+) GTCCC(A/C)GCTAC intron-variant, downstream-variant-500B
rs1000846926 -- 36,136,543(+) GGGGA(C/T)TAACA intron-variant
rs1000868433 -- 36,142,541(+) ATATG(G/T)GCTGT intron-variant, downstream-variant-500B
rs1000877726 -- 36,141,241(+) TGGGC(A/G)ACAGA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CBR3 Gene

Variant ID Type Subtype PubMed ID
dgv4427n100 CNV gain 25217958
dgv7832n54 CNV gain 21841781
dgv813e214 CNV gain 21293372
esv1434184 CNV deletion 17803354
esv2751927 CNV gain 17911159
esv2751928 CNV gain 17911159
esv2763686 CNV gain+loss 21179565
esv33578 CNV loss 17666407
esv3575388 CNV gain 25503493
esv3646963 CNV gain 21293372
nsv1071754 CNV deletion 25765185
nsv459249 CNV gain 19166990
nsv516175 CNV gain 19592680
nsv587464 CNV gain 21841781
nsv587466 CNV gain 21841781
nsv587469 CNV loss 21841781

Variation tolerance for CBR3 Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.22; 98.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CBR3 Gene

Human Gene Mutation Database (HGMD)
CBR3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CBR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBR3 Gene

Disorders for CBR3 Gene

Relevant External Links for CBR3

Genetic Association Database (GAD)
CBR3
Human Genome Epidemiology (HuGE) Navigator
CBR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBR3

No disorders were found for CBR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBR3 Gene

Publications for CBR3 Gene

  1. Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2. (PMID: 9740676) Watanabe K. … Nomura T. (Genomics 1998) 2 3 4 22 64
  2. Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer. (PMID: 18457324) Blanco J.G. … Bhatia S. (Cancer 2008) 3 22 46 64
  3. Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1. (PMID: 18493841) Miura T. … Terada T. (Mol. Cell. Biochem. 2008) 3 4 22 64
  4. CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients. (PMID: 19016765) Lal S. … Chowbay B. (Cancer Sci. 2008) 3 22 46 64
  5. Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3). (PMID: 15537833) Lakhman S.S. … Blanco J.G. (Drug Metab. Dispos. 2005) 3 4 22 64

Products for CBR3 Gene

  • Cloud-Clone Corp. Antibodies for CBR3
  • Cloud-Clone Corp. Proteins for CBR3
  • Cloud-Clone Corp Assay Kits for CBR3
  • Addgene plasmids for CBR3

Sources for CBR3 Gene

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