Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CBR3 Gene

protein-coding   GIFtS: 69
GCID: GC21P037507

Carbonyl Reductase 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

TryGeneCards Plus

Aliases
Carbonyl Reductase 31 2     SDR21C22
NADPH-Dependent Carbonyl Reductase 32 3     Carbonyl Reductase (NADPH) 32
EC 1.1.1.1843 8     Carbonyl Reductase [NADPH] 32
Member 21     Epididymis Secretory Protein Li 252
Short Chain Dehydrogenase/Reductase Family 21C1     hCBR32
Carbonyl Reductase (NADPH) 3, EC 1.1.1.18411     Short Chain Dehydrogenase/Reductase Family 21C, Member 22
HEL-S-252     EC 1.1.18

External Ids:    HGNC: 15491   Entrez Gene: 8742   Ensembl: ENSG000001592317   OMIM: 6036085   UniProtKB: O758283   

Export aliases for CBR3 gene to outside databases

Previous GC identifers: GC21P034084 GC21P034167 GC21P036427 GC21P036429 GC21P022984


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CBR3 Gene:
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active
carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent
oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl
reductase gene - CBR1. (provided by RefSeq, Jul 2008)

GeneCards Summary for CBR3 Gene:
CBR3 (carbonyl reductase 3) is a protein-coding gene. Diseases associated with CBR3 include congestive heart failure, and lung cancer susceptibility. GO annotations related to this gene include 3-keto sterol reductase activity and NADPH binding. An important paralog of this gene is CBR1.

UniProtKB/Swiss-Prot: CBR3_HUMAN, O75828
Function: Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro)

Gene Wiki entry for CBR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000021.9  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CBR3 gene promoter:
         HFH-3   Lmo2   STAT5A   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx5-1   POU3F2   FOXI1   CBF-A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCBR3 promoter sequence

   Search Chromatin IP Primers for CBR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CBR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.2   Ensembl cytogenetic band:  21q22.12   HGNC cytogenetic band: 21q22.2
Nature(405: 311-319) cytogenetic band:   21q22.13
CBR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBR3 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P037507:   GeneLoc Nature:405,311-319
Start:
37,507,210 bp from pter       23,084,242 bp from centromere
End:
37,518,864 bp from pter 23,095,605 bp from centromere
Size:
11,655 bases 11,364 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: AB004854
genomic clones: KB795B7


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CBR3_HUMAN, O75828 (See protein sequence)
Recommended Name: Carbonyl reductase [NADPH] 3  
Size: 277 amino acids; 30850 Da
1 PDB 3D structure from and Proteopedia for CBR3:
2HRB (3D)    
Secondary accessions: Q6FHP2

Explore the universe of human proteins at neXtProt for CBR3: NX_O75828

Explore proteomics data for CBR3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys112
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for CBR3 (O75828)
     KFVEDTK  GRVVNISS  QSIRALRDFL  AAVQQLQAEGLSP 


    See CBR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001227.1  
    ENSEMBL proteins: 
     ENSP00000290354  

    CBR3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CBR3
    OriGene Protein Over-expression Lysate for CBR3
    OriGene MassSpec for CBR3
    OriGene Custom Protein Services for CBR3
    GenScript Custom Purified and Recombinant Proteins Services for CBR3
    Novus Biologicals CBR3 Proteins
    Novus Biologicals CBR3 Lysates
    Sino Biological Recombinant Protein for CBR3
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CBR3
    Cloud-Clone Corp. Proteins for CBR3

    CBR3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CBR3
    OriGene Custom Antibody Services for CBR3
    Novus Biologicals CBR3 Antibodies
    Abcam antibodies for CBR3
    Cloud-Clone Corp. Antibodies for CBR3
    ThermoFisher Antibodies for CBR3
    LSBio Antibodies in human, mouse, rat for CBR3

    CBR3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CBR3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CBR3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CBR3
    Cloud-Clone Corp. CLIAs for CBR3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SDRC1: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

    4 InterPro protein domains:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry O75828

    ProtoNet protein and cluster: O75828

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: CBR3_HUMAN, O75828
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    CBR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBR3_HUMAN, O75828
    Function: Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro)
    Catalytic activity: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH
    Biophysicochemical properties: Kinetic parameters: KM=25 uM for menadione (PubMed:15537833); KM=43 uM for
    menadione (PubMed:18493841); KM=90 uM for NADPH (PubMed:15537833); KM=38 uM for NADPH (PubMed:18493841); pH
    dependence: Optimum pH is 5.5-7;

         Genatlas biochemistry entry for CBR3:
    carbonyl reductase,NADPH-dependent oxidoreductase

         Enzyme Numbers (IUBMB): EC 1.1.1.1841 2 EC 1.1.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00002533-keto sterol reductase activity IEA--
    GO:0004090carbonyl reductase (NADPH) activity IDA18493841
    GO:0016491oxidoreductase activity ----
    GO:0070402NADPH binding IDA18493841
         
    CBR3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CBR3:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CBR3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CBR3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CBR3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CBR3

    miRNA
    Products:
        
    miRTarBase miRNAs that target CBR3:
    hsa-mir-124-3p (MIRT022826)

    Block miRNA regulation of human, mouse, rat CBR3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CBR3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CBR3
    Predesigned siRNA for gene silencing in human, mouse, rat CBR3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CBR3

    Clone
    Products:
         
    OriGene clones in human, mouse for CBR3 (see all 6)
    OriGene ORF clones in mouse, rat for CBR3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CBR3 (NM_001236)
    Sino Biological Human cDNA Clone for CBR3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBR3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CBR3
    Browse ESI BIO Cell Lines and PureStem Progenitors for CBR3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBR3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CBR3_HUMAN, O75828: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus4
    mitochondrion2
    endoplasmic reticulum1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA18493841

    CBR3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CBR3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Chemical carcinogenesis
    Metabolism of xenobiotics by cytochrome P4500.71
    2Doxorubicin Pathway, Pharmacokinetics
    Doxorubicin Pathway, Pharmacokinetics0.43
    3Arachidonic acid metabolism
    Arachidonic acid metabolism0.41
    4Metabolism
    Metabolic pathways0.38
    5Prostaglandin 2 biosynthesis and metabolism FM
    Prostaglandin 2 biosynthesis and metabolism FM

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CBR3
        Prostaglandin 2 biosynthesis and metabolism FM


    2 PharmGKB Pathways for CBR3
        Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics

    3 Kegg Pathways  (Kegg details for CBR3):
        Arachidonic acid metabolism
    Metabolism of xenobiotics by cytochrome P450
    Metabolic pathways


    CBR3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CBR3
    Interactions:

        Search GeneGlobe Interaction Network for CBR3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for CBR3 (O758282, 3 ENSP000002903544) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARIH2O953762, 3MINT-63289 I2D: score=5 
    RAB35Q152862, 3MINT-64229 I2D: score=5 
    USP3Q9Y6I43, ENSP000003696814I2D: score=2 STRING: ENSP00000369681
    SGK1O001413, ENSP000003568324I2D: score=1 STRING: ENSP00000356832
    GABARAPO951663I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0042376phylloquinone catabolic process IEA--

    CBR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CBR3

    9 HMDB Compounds for CBR3    About this table
    CompoundSynonyms CAS #PubMed Ids
    10,11-dihydro-12-oxo-LTB412-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoic acid anion (see all 4)----
    10,11-dihydro-leukotriene B410,11-dihydro-LTB(,4) (see all 6)----
    12-Oxo-20-carboxy-leukotriene B412-oxo-20-COOH-leukotriene B(,4) (see all 5)----
    12-oxo-10,11-dihydro-20-COOH-LTB412-oxo-10,11-dihydro-20-carboxy-LTB(,4) (see all 3)----
    20-COOH-10,11-dihydro-LTB410,11-dihydro-20-COOH-leukotriene B(,4);20-carboxy-10,11-dihydro-LTB(,4);(5S,12R)-dihydroxy-(6Z,8E,14Z)-eicosatrien-1,20-dicarboxylic acid anion ----
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Prostaglandin E2(-)-Prostaglandin E2 (see all 22)363-24-6--
    Prostaglandin F2aProtamodin (see all 37)551-11-1--

    2 Novoseek inferred chemical compound relationships for CBR3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 49.1 8 18983987 (2), 19061875 (1)
    atp 2.53 1 15606508 (1)

    2 PharmGKB related drug/compound annotations for CBR3 gene    About this table
    Drug/compound PharmGKB Annotation
    anthracyclines and related substancesCA  
    doxorubicinCA  



    CBR3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CBR3 gene: 
    NM_001236.3  

    Unigene Cluster for CBR3:

    Carbonyl reductase 3
    Hs.154510  [show with all ESTs]
    Unigene Representative Sequence: AB041012
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000290354(uc002yve.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CBR3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CBR3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CBR3
    Predesigned siRNA for gene silencing in human, mouse, rat CBR3
    Clone
    Products:
         
    OriGene clones in human, mouse for CBR3 (see all 6)
    OriGene ORF clones in mouse, rat for CBR3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CBR3 (NM_001236)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBR3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CBR3
    OriGene qSTAR qPCR primer pairs in human, mouse for CBR3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBR3
      QuantiTect SYBR Green Assays in human, mouse, rat CBR3
      QuantiFast Probe-based Assays in human, mouse, rat CBR3

    Additional mRNA sequence: 

    AB004850.1 AB004854.1 AB041012.1 AB124847.1 AJ000095.1 AJ000096.1 AK223429.1 BC002812.2 
    CR541709.1 

    3 DOTS entries:

    DT.429473  DT.121132730  DT.435430 

    Selected AceView cDNA sequences (see all 55):

    AI352345 AB004850 CN479593 AB004854 AA071157 BI084483 CB159246 BG165774 
    BU150098 BM765037 BM772797 BU629438 BV184417 AI658832 NM_001236 AI652553 
    BQ669678 BM762172 BC002812 BQ440869 AI375520 BG714047 BE408293 AA070863 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CBR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAAGTTGT
    CBR3 Expression
    About this image


    CBR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Gonad
             XY Germ Cells Testis Cord
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Cells Epiblast
    CBR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CBR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.154510

    UniProtKB/Swiss-Prot: CBR3_HUMAN, O75828
    Tissue specificity: Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver,
    spleen, leukocyte, prostate and testis

        Custom PCR Arrays for CBR3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CBR3
    OriGene qSTAR qPCR primer pairs in human, mouse for CBR3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBR3
    QuantiTect SYBR Green Assays in human, mouse, rat CBR3
    QuantiFast Probe-based Assays in human, mouse, rat CBR3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CBR3 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cbr31 , 5 carbonyl reductase 31, 5 83.75(n)1
    85.2(a)1
      16 (54.58 cM)5
    1098571  NM_173047.31  NP_766635.11 
     936832155 
    chicken
    (Gallus gallus)
    Aves CBR16
    Gallus gallus carbonyl reductase 1 (CBR1), mRNA.
    67(a)
    1 → many
    1(105950595-105956078)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    67(a)
    65(a)
    many ↔ many
    many ↔ many
    GL344111.1(4917-14374)
    GL344111.1(16092-20050)
    zebrafish
    (Danio rerio)
    Actinopterygii cbr16
    carbonyl reductase 1
    56(a)
    1 → many
    1(47662949-47670284) ENSDARG00000036587


    ENSEMBL Gene Tree for CBR3 (if available)
    TreeFam Gene Tree for CBR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CBR3 gene
    CBR12  
    1 SIMAP similar gene for CBR3 using alignment to 1 protein entry:     CBR3_HUMAN:
    CBR1

    CBR3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    7 SNPs for CBR3    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10568921,2,4
    ----see VAR_0338732 mis40--------
    rs81330521,2,4
    ----see VAR_0338682 mis40--------
    rs169939291,2,4
    ----see VAR_0338712 mis40--------
    rs92826281,2,4
    ----see VAR_0338692 mis40--------
    rs49871211,2,4
    ----see VAR_0338722 mis40--------
    rs28352851,2,4
    ----see VAR_0338702 mis40--------
    rs3734458571,2
    ----22982936(+) CCCAGC/GCACGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CBR3 (37507210 - 37518864 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CBR3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1434184CNV Deletion17803354
    esv33578CNV Loss17666407
    nsv913733CNV Loss21882294
    esv2751927CNV Gain17911159
    esv2751928CNV Gain17911159
    nsv516175CNV Gain19592680
    nsv459249CNV Gain19166990

    Human Gene Mutation Database (HGMD): CBR3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CBR3
    DNA2.0 Custom Variant and Variant Library Synthesis for CBR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603608    OMIM disorders: --

    12 diseases for CBR3:    
    About MalaCards
    congestive heart failure    lung cancer susceptibility    keloids    down syndrome
    parkinson's disease    insulin resistance    lung cancer    ovarian cancer
    esophagitis    breast cancer    hepatitis    prostatitis


    CBR3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CBR3
    Human Genome Epidemiology (HuGE) Navigator: CBR3 (9 documents)

    Export disorders for CBR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CBR3 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with CBR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2. (PubMed id 9740676)1, 2, 3, 9 Watanabe K.... Nomura T. (Genomics 1998)
    2. Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1. (PubMed id 18493841)1, 2, 9 Miura T.... Terada T. (Mol. Cell. Biochem. 2008)
    3. Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3). (PubMed id 15537833)1, 2, 9 Lakhman S.S.... Blanco J.G. (Drug Metab. Dispos. 2005)
    4. CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients. (PubMed id 19016765)1, 4, 9 Lal S....Chowbay B. (Cancer Sci. 2008)
    5. Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer. (PubMed id 18457324)1, 4, 9 Blanco J.G....Bhatia S. (Cancer 2008)
    6. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    7. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    8. Nitric oxide synthase variants and disease-free survival among treated and untreated breast cancer patients in a Southwest Oncology Group clinical trial. (PubMed id 19671875)1, 4 Choi J.Y....Ambrosone C.B. (Clin. Cancer Res. 2009)
    9. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    10. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 874 HGNC: 1549 AceView: CBR3 Ensembl:ENSG00000159231 euGenes: HUgn874
    ECgene: CBR3 Kegg: 874 H-InvDB: CBR3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CBR3 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/cbr3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CBR3 gene:
    Search GeneIP for patents involving CBR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CBR3   OriGene RNAi products in human, mouse, rat for CBR3  
     OriGene qPCR primer pairs and template standards for CBR3   OriGene Protein Over-expression Lysate for CBR3  
     OriGene MassSpec something-or-other for CBR3   OriGene clones in human, mouse for CBR3  
     OriGene qSTAR qPCR primer pairs in human, mouse for CBR3   OriGene Purified Protein for CBR3  
     OriGene ORF clones in mouse, rat for CBR3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CBR3   OriGene Custom Protein Services for CBR3  

     
     
     Block miRNA regulation of human, mouse, rat CBR3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CBR3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CBR3 Predesigned siRNA for gene silencing in human, mouse, rat CBR3
     QuantiFast Probe-based Assays in human, mouse, rat CBR3 QuantiTect SYBR Green Assays in human, mouse, rat CBR3
     Custom PCR Arrays for CBR3 Search Chromatin IP Primers for CBR3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBR3  Search GeneGlobe Interaction Network for CBR3
     Regulatory tfbs in CBR3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CBR3 GenScript cDNA clones with any tag delivered in your preferred vector for CBR3
     GenScript Custom Assay Services for CBR3 GenScript Custom overexpressing Cell Line Services for CBR3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CBR3
     Proteins for CBR3
     Browse Sino Biological Cell Lysates
     cDNA Clones for CBR3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CBR3 antibodies
     CBR3 proteins
     CBR3 lysates
     Antibodies for CBR3
     See all of Abcam's Antibodies, Kits and Proteins for CBR3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CBR3
     Proteins for CBR3
     Antibodies for CBR3
     ELISAs for CBR3
     CLIAs for CBR3



     Browse ESI BIO Cell Lines and PureStem Progenitors for CBR3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBR3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CBR3
     SwitchGear Promoter luciferase reporter plasmids for CBR3
     ThermoFisher Antibodies for CBR3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBR3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CBR3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CBR3
     LSBio Antibodies in human, mouse, rat for CBR3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CBR3 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4