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Aliases for CBR1 Gene

Aliases for CBR1 Gene

  • Carbonyl Reductase 1 2 3
  • Short Chain Dehydrogenase/Reductase Family 21C Member 1 3 4
  • NADPH-Dependent Carbonyl Reductase 1 3 4
  • Prostaglandin-E(2) 9-Reductase 3 4
  • Prostaglandin 9-Ketoreductase 3 4
  • EC 1.1.1.184 4 64
  • SDR21C1 3 4
  • CBR 3 4
  • Short Chain Dehydrogenase/Reductase Family 21C, Member 1 3
  • 15-Hydroxyprostaglandin Dehydrogenase [NADP(+)] 4
  • Short Chain Dehydrogenase/Reductase Family 21C 2
  • 15-Hydroxyprostaglandin Dehydrogenase 3
  • Carbonyl Reductase (NADPH) 1 3
  • Carbonyl Reductase [NADPH] 1 3
  • EC 1.1.1.197 4
  • EC 1.1.1.189 4
  • Member 1 2
  • HCBR1 3
  • CRN 4

External Ids for CBR1 Gene

Previous Symbols for CBR1 Gene

  • CBR

Summaries for CBR1 Gene

Entrez Gene Summary for CBR1 Gene

  • The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for CBR1 Gene

CBR1 (Carbonyl Reductase 1) is a Protein Coding gene. Diseases associated with CBR1 include lung cancer. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor and 15-hydroxyprostaglandin dehydrogenase (NADP+) activity. An important paralog of this gene is CBR3.

UniProtKB/Swiss-Prot for CBR1 Gene

  • NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

Gene Wiki entry for CBR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBR1 Gene

Genomics for CBR1 Gene

Genomic Location for CBR1 Gene

Start:
36,069,924 bp from pter
End:
36,073,177 bp from pter
Size:
3,254 bases
Orientation:
Plus strand

Genomic View for CBR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CBR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBR1 Gene

Regulatory Elements for CBR1 Gene

Proteins for CBR1 Gene

  • Protein details for CBR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16152-CBR1_HUMAN
    Recommended name:
    Carbonyl reductase [NADPH] 1
    Protein Accession:
    P16152
    Secondary Accessions:
    • B2RBZ7
    • B4DFK7
    • Q3LHW8

    Protein attributes for CBR1 Gene

    Size:
    277 amino acids
    Molecular mass:
    30375 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CBR1 Gene

    Alternative splice isoforms for CBR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CBR1 Gene

Proteomics data for CBR1 Gene at MOPED

Post-translational modifications for CBR1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys174 and Lys186

Other Protein References for CBR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CBR1 Gene

Gene Families for CBR1 Gene

HGNC:
  • SDRC1 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1
IUPHAR :

UniProtKB/Swiss-Prot:

CBR1_HUMAN
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.:
    • P16152
genes like me logo Genes that share domains with CBR1: view

Function for CBR1 Gene

Molecular function for CBR1 Gene

GENATLAS Biochemistry: carbonyl reductase,NADPH-dependent oxidoreductase,cytosolic,involved in the metabolism of many carbonyl compounds,including antitumor anthracyne antibiotics
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=30 uM for S-nitrosoglutathione {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=22 uM for menadione {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=309 uM for prostaglandin E2 {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=173 uM for daunorubicin {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=247 uM for NADPH {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943};
UniProtKB/Swiss-Prot CatalyticActivity: R-CHOH-R + NADP(+) = R-CO-R + NADPH
UniProtKB/Swiss-Prot CatalyticActivity: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH
UniProtKB/Swiss-Prot CatalyticActivity: (13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by quercetin, rutenin and its derivatives.
UniProtKB/Swiss-Prot Function: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

Enzyme Numbers (IUBMB) for CBR1 Gene

Gene Ontology (GO) - Molecular Function for CBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004090 carbonyl reductase (NADPH) activity IDA 18449627
GO:0016491 oxidoreductase activity --
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA 19442656
GO:0047021 15-hydroxyprostaglandin dehydrogenase (NADP+) activity IEA --
GO:0050221 prostaglandin-E2 9-reductase activity IEA --
genes like me logo Genes that share ontologies with CBR1: view

Phenotypes for CBR1 Gene

GenomeRNAi human phenotypes for CBR1:
genes like me logo Genes that share phenotypes with CBR1: view

miRNA for CBR1 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CBR1 Gene

Localization for CBR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBR1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBR1 Gene COMPARTMENTS Subcellular localization image for CBR1 gene
Compartment Confidence
cytosol 4
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0031982 vesicle IDA 24769233
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CBR1: view

Pathways for CBR1 Gene

genes like me logo Genes that share pathways with CBR1: view

Gene Ontology (GO) - Biological Process for CBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0017144 drug metabolic process IDA 18449627
GO:0019369 arachidonic acid metabolic process TAS --
GO:0019371 cyclooxygenase pathway TAS --
GO:0030855 epithelial cell differentiation IEP 21492153
genes like me logo Genes that share ontologies with CBR1: view

Compounds for CBR1 Gene

(15) HMDB Compounds for CBR1 Gene

Compound Synonyms Cas Number PubMed IDs
(13E)-11a-Hydroxy-9,15-dioxoprost-13-enoic acid
  • (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate
22973-19-9
10,11-dihydro-12-oxo-LTB4
  • 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoic acid anion
Not Available
10,11-dihydro-leukotriene B4
  • 10,11-dihydro-LTB(,4)
Not Available
12-oxo-10,11-dihydro-20-COOH-LTB4
  • 12-oxo-10,11-dihydro-20-carboxy-LTB(,4)
Not Available
12-Oxo-20-carboxy-leukotriene B4
  • 12-oxo-20-COOH-leukotriene B(,4)
Not Available

(11) Novoseek inferred chemical compound relationships for CBR1 Gene

Compound -log(P) Hits PubMed IDs
daunorubicinol 92.5 2
9,10-phenanthrenequinone 83.5 1
menadione 71.3 4
daunorubicin 64.3 11
nadph 51.8 4

(3) PharmGKB related drug/compound annotations for CBR1 Gene

genes like me logo Genes that share compounds with CBR1: view

Transcripts for CBR1 Gene

Unigene Clusters for CBR1 Gene

Carbonyl reductase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CBR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for CBR1 Gene

GeneLoc Exon Structure for
CBR1
ECgene alternative splicing isoforms for
CBR1

Expression for CBR1 Gene

mRNA expression in normal human tissues for CBR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CBR1 Gene

SOURCE GeneReport for Unigene cluster for CBR1 Gene Hs.88778

genes like me logo Genes that share expressions with CBR1: view

Orthologs for CBR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CBR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CBR1 36
  • 99.04 (n)
  • 100 (a)
CBR1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 88 (a)
OneToMany
CBR1 36
  • 86.4 (n)
  • 88.81 (a)
MGC127133 37
  • 78 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 88 (a)
OneToMany
-- 37
  • 79 (a)
OneToMany
-- 37
  • 74 (a)
OneToMany
LOC610164 36
  • 86.88 (n)
  • 88.45 (a)
mouse
(Mus musculus)
Mammalia Cbr1 36
  • 83.87 (n)
  • 87.73 (a)
Cbr1 16
Cbr1 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 73 (a)
ManyToMany
-- 37
  • 83 (a)
ManyToMany
-- 37
  • 82 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 77 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cbr1 36
  • 83.63 (n)
  • 85.92 (a)
chicken
(Gallus gallus)
Aves CBR1 36
  • 72.12 (n)
  • 78.55 (a)
CBR1 37
  • 78 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 75 (a)
ManyToMany
-- 37
  • 77 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.21423 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cbr3 36
  • 71.83 (n)
  • 75.65 (a)
Str.11980 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9689 36
zebrafish
(Danio rerio)
Actinopterygii cbr1 36
  • 64.48 (n)
  • 66.18 (a)
cbr1 37
  • 66 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G61830 36
  • 46.04 (n)
  • 40 (a)
rice
(Oryza sativa)
Liliopsida Os01g0929500 36
  • 49.62 (n)
  • 39.39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1580 36
Species with no ortholog for CBR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBR1 Gene

ENSEMBL:
Gene Tree for CBR1 (if available)
TreeFam:
Gene Tree for CBR1 (if available)

Paralogs for CBR1 Gene

Paralogs for CBR1 Gene

Selected SIMAP similar genes for CBR1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CBR1 Gene

genes like me logo Genes that share paralogs with CBR1: view

Variants for CBR1 Gene

Sequence variations from dbSNP and Humsavar for CBR1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs3761354 -- 36,067,975(+) tgtca(A/G)tatct upstream-variant-2KB
rs6517327 -- 36,068,594(+) ggctc(A/G)ctgca upstream-variant-2KB
rs9974111 -- 36,068,810(+) gctga(A/G)attac upstream-variant-2KB
rs9974454 -- 36,068,696(+) ttttg(G/T)atttt upstream-variant-2KB
rs34005811 -- 36,068,720(+) TTTTT(-/T)TAGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CBR1 Gene

Variant ID Type Subtype PubMed ID
nsv913730 CNV Gain 21882294
nsv470899 CNV Loss 18288195
nsv459247 CNV Loss 19166990
esv2751927 CNV Gain 17911159

Relevant External Links for CBR1 Gene

HapMap Linkage Disequilibrium report
CBR1
Human Gene Mutation Database (HGMD)
CBR1

Disorders for CBR1 Gene

(1) MalaCards Diseases for CBR1 Gene

Search for CBR1 Gene in MalaCards »

(4) Novoseek inferred disease relationships for CBR1 Gene

Disease -log(P) Hits PubMed IDs
down syndrome 44.1 4
cancer 18.5 2
tumors 0 5
alzheimers disease 0 1

Relevant External Links for CBR1

Genetic Association Database (GAD)
CBR1
Human Genome Epidemiology (HuGE) Navigator
CBR1
genes like me logo Genes that share disorders with CBR1: view

No data available for UniProtKB/Swiss-Prot for CBR1 Gene

Publications for CBR1 Gene

  1. Human carbonyl reductase (CBR) localized to band 21q22.1 by high-resolution fluorescence in situ hybridization displays gene dosage effects in trisomy 21 cells. (PMID: 8432528) Lemieux N. … Forrest G.L. (Genomics 1993) 2 3 23
  2. Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2. (PMID: 9740676) Watanabe K. … Nomura T. (Genomics 1998) 3 4 23
  3. A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity. (PMID: 17344335) Gonzalez-Covarrubias V. … Blanco J.G. (Drug Metab. Dispos. 2007) 3 4 23
  4. Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER). (PMID: 18449627) Gonzalez-Covarrubias V. … Blanco J.G. (Pharm. Res. 2008) 3 4 23
  5. Human carbonyl reductase 1 is an S-nitrosoglutathione reductase. (PMID: 18826943) Bateman R.L. … Shokat K.M. (J. Biol. Chem. 2008) 3 4 23

Products for CBR1 Gene

Sources for CBR1 Gene

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