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CBR1 Gene

protein-coding   GIFtS: 72
GCID: GC21P037442

Carbonyl Reductase 1


(Previous symbol: CBR)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Carbonyl Reductase 11 2     SDR21C12
CBR1 2 3     Carbonyl Reductase (NADPH) 12
Prostaglandin 9-Ketoreductase2 3     Carbonyl Reductase [NADPH] 12
Prostaglandin-E(2) 9-Reductase2 3     hCBR12
NADPH-Dependent Carbonyl Reductase 12 3     Short Chain Dehydrogenase/Reductase Family 21C, Member 12
EC 1.1.1.1843 8     15-Hydroxyprostaglandin Dehydrogenase [NADP(+)]3
Member 11     CRN3
Short Chain Dehydrogenase/Reductase Family 21C1     EC 1.1.1.1893
Carbonyl Reductase (NADPH) 1, EC 1.1.1.18411     EC 1.1.1.1973
15-Hydroxyprostaglandin Dehydrogenase2     

External Ids:    HGNC: 15481   Entrez Gene: 8732   Ensembl: ENSG000001592287   OMIM: 1148305   UniProtKB: P161523   

Export aliases for CBR1 gene to outside databases

Previous GC identifers: GC21P034019 GC21P036362 GC21P036364 GC21P022920


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CBR1 Gene:
The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function
as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones,
prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene.
(provided by RefSeq, Nov 2013)

GeneCards Summary for CBR1 Gene:
CBR1 (carbonyl reductase 1) is a protein-coding gene. Diseases associated with CBR1 include lung cancer susceptibility, and down syndrome. GO annotations related to this gene include oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor and 15-hydroxyprostaglandin dehydrogenase (NADP+) activity. An important paralog of this gene is CBR3.

UniProtKB/Swiss-Prot: CBR1_HUMAN, P16152
Function: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of
carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the
reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol
and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains
its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione

Gene Wiki entry for CBR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CBR1 gene promoter:
         AML1a   Olf-1   FOXD3   RelA   NF-E2 p45   Ik-3   Max   ARP-1   NF-E2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCBR1 promoter sequence

   Search Chromatin IP Primers for CBR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CBR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.13   Ensembl cytogenetic band:  21q22.12   HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band:   21q22.13
CBR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBR1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P037442:   GeneLoc Nature:405,311-319
Start:
37,442,239 bp from pter       23,019,072 bp from centromere
End:
37,445,464 bp from pter 23,022,213 bp from centromere
Size:
3,226 bases 3,142 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: J04056
genomic clones: P27A22


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CBR1_HUMAN, P16152 (See protein sequence)
Recommended Name: Carbonyl reductase [NADPH] 1  
Size: 277 amino acids; 30375 Da
Subunit: Monomer
5 PDB 3D structures from and Proteopedia for CBR1:
1WMA (3D)        2PFG (3D)        3BHI (3D)        3BHJ (3D)        3BHM (3D)    
Secondary accessions: B2RBZ7 Q3LHW8

Explore the universe of human proteins at neXtProt for CBR1: NX_P16152

Explore proteomics data for CBR1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys174, Lys186
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CBR1 (P16152) (see all 7)
     KFVEDTK  AEGPHGQFV  QSIRALRDFL  GTRDVCTELLPL 


    See CBR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273718.1  NP_001748.1  

    ENSEMBL proteins: 
     ENSP00000434613   ENSP00000290349   ENSP00000395132   ENSP00000382143  
    Reactome Protein details: P16152

    CBR1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for CBR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDRC1: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

    IUPHAR Guide to PHARMACOLOGY protein family classification: CBR1
    Prostaglandin synthases

    4 InterPro protein domains:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P16152

    ProtoNet protein and cluster: P16152

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: CBR1_HUMAN, P16152
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    CBR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBR1_HUMAN, P16152
    Function: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of
    carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the
    reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol
    and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains
    its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione
    Catalytic activity: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH
    Catalytic activity: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) =
    (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH
    Catalytic activity: (13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) =
    (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH
    Enzyme regulation: Inhibited by quercetin, rutenin and its derivatives
    Biophysicochemical properties: Kinetic parameters: KM=30 uM for S-nitrosoglutathione; KM=22 uM for menadione;
    KM=309 uM for prostaglandin E2; KM=173 uM for daunorubicin; KM=247 uM for NADPH;

         Genatlas biochemistry entry for CBR1:
    carbonyl reductase,NADPH-dependent oxidoreductase,cytosolic,involved in the metabolism of many carbonyl
    compounds,including antitumor anthracyne antibiotics

         Enzyme Numbers (IUBMB): EC 1.1.1.1841 2 EC 1.1.1.1971 EC 1.1.1.1891

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004090carbonyl reductase (NADPH) activity IDA18449627
    GO:0016491oxidoreductase activity ----
    GO:0016655oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA19442656
    GO:004702115-hydroxyprostaglandin dehydrogenase (NADP+) activity IEA--
    GO:0050221prostaglandin-E2 9-reductase activity IEA--
         
    CBR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CBR1:
     Synthetic lethal with paclitax 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target CBR1:
    hsa-mir-484 (MIRT042005), hsa-mir-186-5p (MIRT045152), hsa-mir-92a-3p (MIRT049536), hsa-mir-93-3p (MIRT038897)

    Block miRNA regulation of human, mouse, rat CBR1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CBR1
    SwitchGear 3'UTR luciferase reporter plasmidCBR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CBR1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CBR1_HUMAN, P16152: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    CBR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CBR1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.41
    Synthesis of Prostaglandins (PG) and Thromboxanes (TX)0.00
    Arachidonic acid metabolism0.40
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3Chemical carcinogenesis
    Metabolism of xenobiotics by cytochrome P4500.71
    Chemical carcinogenesis0.71
    4Doxorubicin Pathway, Pharmacokinetics
    Doxorubicin Pathway, Pharmacokinetics0.43
    5Prostaglandin 2 biosynthesis and metabolism FM
    Prostaglandin 2 biosynthesis and metabolism FM

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CBR1
        Prostaglandin 2 biosynthesis and metabolism FM

    1 Reactome Pathway for CBR1
        Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

    2 PharmGKB Pathways for CBR1
        Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics

    4 Kegg Pathways  (Kegg details for CBR1):
        Arachidonic acid metabolism
    Metabolism of xenobiotics by cytochrome P450
    Metabolic pathways
    Chemical carcinogenesis


    CBR1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CBR1
    Interactions:

        Search GeneGlobe Interaction Network for CBR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for CBR1 (P161522, 3 ENSP000002903494) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206435P305043I2D: score=1 
    ENSG00000206452P305043I2D: score=1 
    HLA-CP305043I2D: score=1 
    ERCC8Q132162, 3, ENSP000002650384MINT-63481 I2D: score=4 STRING: ENSP00000265038
    UBA5Q9GZZ93, ENSP000003485654I2D: score=3 STRING: ENSP00000348565
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0017144drug metabolic process IDA18449627
    GO:0019369arachidonic acid metabolic process TAS--
    GO:0019371cyclooxygenase pathway TAS--
    GO:0030855epithelial cell differentiation IEP--

    CBR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CBR1

    Selected HMDB Compounds for CBR1 (see all 15)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (13E)-11a-Hydroxy-9,15-dioxoprost-13-enoic acid(13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate (see all 25)22973-19-9--
    10,11-dihydro-12-oxo-LTB412-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoic acid anion (see all 4)----
    10,11-dihydro-leukotriene B410,11-dihydro-LTB(,4) (see all 6)----
    12-Oxo-20-carboxy-leukotriene B412-oxo-20-COOH-leukotriene B(,4) (see all 5)----
    12-oxo-10,11-dihydro-20-COOH-LTB412-oxo-10,11-dihydro-20-carboxy-LTB(,4) (see all 3)----
    20-COOH-10,11-dihydro-LTB410,11-dihydro-20-COOH-leukotriene B(,4);20-carboxy-10,11-dihydro-LTB(,4);(5S,12R)-dihydroxy-(6Z,8E,14Z)-eicosatrien-1,20-dicarboxylic acid anion ----
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Prostaglandin E1(-)-Prostaglandin E1 (see all 30)745-65-3--
    Prostaglandin E2(-)-Prostaglandin E2 (see all 22)363-24-6--

    7 DrugBank Compounds for CBR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Acetohexamide-- 968-81-0enzymesubstrate15635190 8070312 9208371
    Lubiprostone-- 136790-76-6enzymesubstrate18686757 19236188
    3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol-- --target--10592235
    enzyme----
    DoxorubicinAdria (see all 4)23214-92-8enzymesubstrate18635746
    Haloperidol-- 52-86-8enzymesubstrate19515014
    TetrabenazineRo 1-9569 (see all 7)58-46-8enzymesubstrate22014129
    2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400-- --target----
    enzyme----

    Selected Novoseek inferred chemical compound relationships for CBR1 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    daunorubicinol 92.5 4 7553643 (1), 18449627 (1)
    9,10-phenanthrenequinone 83.5 2 7553643 (1)
    menadione 71.3 5 16478651 (2), 7553643 (1), 18449627 (1)
    daunorubicin 64.3 18 7553643 (4), 17482758 (2), 18449627 (2), 17344335 (1) (see all 6)
    nadph 51.8 4 19555696 (2), 17344335 (2)
    quinone 49.7 3 7553643 (1), 16478651 (1), 18449627 (1)
    prostaglandin 42 13 1449827 (3), 1597188 (2), 9408054 (2), 17697149 (1) (see all 5)
    aldose 41.7 2 17270157 (1), 17482758 (1)
    proline 38.2 4 19061875 (1), 18983987 (1)
    pge2 23.6 7 17344335 (1)

    3 PharmGKB related drug/compound annotations for CBR1 gene    About this table
    Drug/compound PharmGKB Annotation
    anthracyclines and related substancesCA  
    doxorubicinCA  
    doxorubicinolCA  



    CBR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CBR1 gene (2 alternative transcripts): 
    NM_001286789.1  NM_001757.3  

    Unigene Cluster for CBR1:

    Carbonyl reductase 1
    Hs.88778  [show with all ESTs]
    Unigene Representative Sequence: AK311219
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466328 ENST00000530908(uc010gmy.1) ENST00000290349(uc002yvb.1)
    ENST00000439427(uc010gmx.1) ENST00000399191

    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat CBR1

    Additional mRNA sequence: 

    AB124848.1 AK294142.1 AK308691.1 AK311219.1 AK314879.1 BC002511.2 BC015640.2 BT019843.1 
    CR541708.1 J04056.1 

    12 DOTS entries:

    DT.215805  DT.448351  DT.100817100  DT.121139210  DT.92444566  DT.95184834  DT.100810591  DT.100817103 
    DT.100817104  DT.121139196  DT.121139203  DT.91755272 

    Selected AceView cDNA sequences (see all 306):

    CB141311 BQ012069 CD364372 BQ431863 BU687215 CF128017 CF129047 BM697430 
    BU151649 CB138588 BP368845 BE385751 T83624 CR604950 BU188488 BM725822 
    AU134655 BF792860 BG680023 BM677941 CF127490 T83601 BF726301 AI355930 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CBR1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
    SP1:                                -     -     -               
    SP2:                                -                           
    SP3:                                -     -                     
    SP4:                                                            


    ECgene alternative splicing isoforms for CBR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CBR1 expression in normal human tissues (normalized intensities)      CBR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCCATTT
    CBR1 Expression
    About this image


    CBR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Thymus (Hematopoietic System)
             Thymus
    CBR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CBR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.88778
        Custom PCR Arrays for CBR1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CBR1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cbr11 , 5 carbonyl reductase 11, 5 83.87(n)1
    87.73(a)1
      16 (54.53 cM)5
    124081  NM_007620.21  NP_031646.21 
     936078375 
    chicken
    (Gallus gallus)
    Aves CBR11 carbonyl reductase 1 72.12(n)
    78.55(a)
      418512  NM_001030795.1  NP_001025966.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    77(a)
    75(a)
    many ↔ many
    many ↔ many
    GL344111.1(4917-14374)
    GL344111.1(16092-20050)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.214232 Xenopus laevis transcribed sequence with moderate similarity more 76.53(n)    CB558671.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cbr12 carbonyl reductase 1 77.93(n)   373866  BC054914.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G618301 AT5G61830 46.04(n)
    40(a)
      836305  NM_125577.4  NP_200991.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g09295001 Os01g0929500 49.62(n)
    39.39(a)
      4326939  NM_001051818.1  NP_001045283.1 


    ENSEMBL Gene Tree for CBR1 (if available)
    TreeFam Gene Tree for CBR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CBR1 gene
    CBR32  
    1 SIMAP similar gene for CBR1 using alignment to 4 protein entries:     CBR1_HUMAN (see all proteins):
    CBR3

    CBR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CBR1
    PGOHUM00000239755


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CBR1 (see all 33)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460085191,2
    --37440313(+) ATATGA/TTACTA 1 -- us2k10--------
    rs415564131,2
    C,F--37440393(+) TAGCTC/TGACAA 1 -- us2k13Minor allele frequency- T:0.04NS WA 212
    rs1386359701,2
    --37440579(+) TGACCA/GCTAAC 1 -- us2k10--------
    rs1493340901,2
    --37440603(+) GAGCAC/TTGGAG 1 -- us2k10--------
    rs415451151,2
    C--37440665(+) TTTATG/ATTTAA 1 -- us2k12Minor allele frequency- A:0.01NS 94
    rs1444390171,2
    --37440708(+) CAGCAC/GAGAAA 1 -- us2k10--------
    rs415637151,2
    C,F--37440750(+) AAGTAG/CGAAGG 1 -- us2k12Minor allele frequency- C:0.01NS 94
    rs415552141,2
    C,F--37440765(+) ACACTC/TACTTT 1 -- us2k12Minor allele frequency- T:0.04NS 88
    rs1471595251,2
    --37440785(+) CAATTA/GTCCCA 1 -- us2k10--------
    rs1404329241,2
    --37440887(+) ATCTCC/GGCTCG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CBR1 (37442239 - 37445464 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CBR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv459247CNV Loss19166990
    nsv470899CNV Loss18288195
    nsv913730CNV Gain21882294
    esv2751927CNV Gain17911159

    Human Gene Mutation Database (HGMD): CBR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CBR1
    DNA2.0 Custom Variant and Variant Library Synthesis for CBR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114830    OMIM disorders: --

    17 diseases for CBR1:    About MalaCards
    lung cancer susceptibility    down syndrome    alzheimer's disease    parkinson's disease
    lung cancer    tonsillitis    acute myeloid leukemia    myeloid leukemia
    cerebritis    esophagitis    schizophrenia    breast cancer
    thyroiditis    hepatitis    leukemia    endotheliitis
    prostatitis


    CBR1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for CBR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    down syndrome 44.1 8 8432528 (3), 11771743 (1)
    cancer 18.5 3 18493841 (1), 7553643 (1)
    tumors 0 7 16103446 (4), 7553643 (1)
    alzheimers disease 0 2 8432528 (1)

    Genetic Association Database (GAD): CBR1
    Human Genome Epidemiology (HuGE) Navigator: CBR1 (7 documents)

    Export disorders for CBR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CBR1 gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with CBR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pharmacogenetics of human carbonyl reductase 1 (CBR1) in livers from black and white donors. (PubMed id 19022938)1, 4, 9 Gonzalez-Covarrubias V....Blanco J.G. (Drug Metab. Dispos. 2009)
    2. Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER). (PubMed id 18449627)1, 2, 9 Gonzalez-Covarrubias V.... Blanco J.G. (Pharm. Res. 2008)
    3. Human carbonyl reductase 1 is an S-nitrosoglutathione reductase. (PubMed id 18826943)1, 2, 9 Bateman R.L.... Shokat K.M. (J. Biol. Chem. 2008)
    4. A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity. (PubMed id 17344335)1, 2, 9 Gonzalez-Covarrubias V....Blanco J.G. (Drug Metab. Dispos. 2007)
    5. Human carbonyl reductase (CBR) localized to band 21q22.1 by high-resolution fluorescence in situ hybridization displays gene dosage effects in trisomy 21 cells. (PubMed id 8432528)1, 3, 9 Lemieux N....Forrest G.L. (Genomics 1993)
    6. CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients. (PubMed id 19016765)1, 4, 9 Lal S....Chowbay B. (Cancer Sci. 2008)
    7. Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2. (PubMed id 9740676)1, 2, 9 Watanabe K.... Nomura T. (Genomics 1998)
    8. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    9. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    10. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 873 HGNC: 1548 AceView: CBR1 Ensembl:ENSG00000159228 euGenes: HUgn873
    ECgene: CBR1 Kegg: 873 H-InvDB: CBR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CBR1 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/cbr1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CBR1 gene:
    Search GeneIP for patents involving CBR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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