Aliases for CBR1 Gene
External Ids for CBR1 Gene
Previous HGNC Symbols for CBR1 Gene
Previous GeneCards Identifiers for CBR1 Gene
The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
GeneCards Summary for CBR1 Gene
CBR1 (Carbonyl Reductase 1) is a Protein Coding gene. Diseases associated with CBR1 include Retinitis Pigmentosa 58. Among its related pathways are Arachidonic acid metabolism and Doxorubicin Pathway, Pharmacokinetics. GO annotations related to this gene include oxidoreductase activity and carbonyl reductase (NADPH) activity. An important paralog of this gene is CBR3.
UniProtKB/Swiss-Prot for CBR1 Gene
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.