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Aliases for CBR1 Gene

Aliases for CBR1 Gene

  • Carbonyl Reductase 1 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 21C Member 1 3 4
  • NADPH-Dependent Carbonyl Reductase 1 3 4
  • Prostaglandin-E(2) 9-Reductase 3 4
  • Prostaglandin 9-Ketoreductase 3 4
  • EC 1.1.1.184 4 61
  • SDR21C1 3 4
  • CBR 3 4
  • Short Chain Dehydrogenase/Reductase Family 21C, Member 1 2
  • 15-Hydroxyprostaglandin Dehydrogenase [NADP(+)] 4
  • 15-Hydroxyprostaglandin Dehydrogenase 3
  • Carbonyl Reductase (NADPH) 1 3
  • Carbonyl Reductase [NADPH] 1 3
  • EC 1.1.1.197 4
  • EC 1.1.1.189 4
  • HCBR1 3
  • CRN 4

External Ids for CBR1 Gene

Previous HGNC Symbols for CBR1 Gene

  • CBR

Previous GeneCards Identifiers for CBR1 Gene

  • GC21P034019
  • GC21P036362
  • GC21P036364
  • GC21P037442
  • GC21P022920

Summaries for CBR1 Gene

Entrez Gene Summary for CBR1 Gene

  • The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for CBR1 Gene

CBR1 (Carbonyl Reductase 1) is a Protein Coding gene. Diseases associated with CBR1 include Retinitis Pigmentosa 58. Among its related pathways are Arachidonic acid metabolism and Doxorubicin Pathway, Pharmacokinetics. GO annotations related to this gene include oxidoreductase activity and carbonyl reductase (NADPH) activity. An important paralog of this gene is CBR3.

UniProtKB/Swiss-Prot for CBR1 Gene

  • NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

Gene Wiki entry for CBR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBR1 Gene

Genomics for CBR1 Gene

Regulatory Elements for CBR1 Gene

Enhancers for CBR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G036059 1.1 ENCODE 38.6 -9.5 -9487 2.5 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 ZNF207 ZNF143 LINC01436 CBR1 SETD4 LOC105369306 LOC105369295 RNU6-992P
GH21G036063 0.7 ENCODE 43.3 -5.9 -5858 1.2 NR2F1 MAFG DPF2 TCF12 ARID1B SMARCA4 ZNF512 IKZF1 NR2F6 HNF4A CBR1 LINC01436 RNU6-992P LOC105369295
GH21G036081 0.7 dbSUPER 39.4 +12.0 11997 0.9 TAL1 YY1 TCF12 FOXM1 HNF4G BHLHE40 ZEB2 ZNF592 FOXA1 ARID1B CBR1 LOC105369295 LINC01436 SETD4 ENSG00000236119
GH21G036076 1.4 Ensembl ENCODE dbSUPER 18.2 +7.3 7284 1.6 HDAC1 HDGF YBX3 CREB3L1 YY1 TCF12 CEBPB USF2 ZNF398 ZNF592 LINC01436 CBR1 LOC105369306 SETD4
GH21G036078 1.5 Ensembl ENCODE dbSUPER 16.8 +9.3 9316 2.0 HNRNPUL1 ATF1 CREB3L1 YY1 TCF12 ZNF766 GATA2 FOS KLF13 ZNF263 LINC01436 CBR1 RIMKLBP1 SETD4 LOC105369306 CBR3-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CBR1 on UCSC Golden Path with GeneCards custom track

Promoters for CBR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000141972 476 1201 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF263 SP3 SP5 ZHX2 NFYC

Genomic Location for CBR1 Gene

Chromosome:
21
Start:
36,069,924 bp from pter
End:
36,073,177 bp from pter
Size:
3,254 bases
Orientation:
Plus strand

Genomic View for CBR1 Gene

Genes around CBR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBR1 Gene

Proteins for CBR1 Gene

  • Protein details for CBR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16152-CBR1_HUMAN
    Recommended name:
    Carbonyl reductase [NADPH] 1
    Protein Accession:
    P16152
    Secondary Accessions:
    • B2RBZ7
    • B4DFK7
    • Q3LHW8

    Protein attributes for CBR1 Gene

    Size:
    277 amino acids
    Molecular mass:
    30375 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CBR1 Gene

    Alternative splice isoforms for CBR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CBR1 Gene

Selected DME Specific Peptides for CBR1 Gene

P16152:
  • AEGPHGQFV
  • NACCPGWVRTDM
  • GTRDVCTELLPL
  • AAVQQLQAEGLSP
  • TPFHIQAEVTMKTNF
  • KFVEDTK
  • QSIRALRDFL

Post-translational modifications for CBR1 Gene

  • Ubiquitination at posLast=174174 and posLast=186186
  • Modification sites at PhosphoSitePlus

Other Protein References for CBR1 Gene

Domains & Families for CBR1 Gene

Gene Families for CBR1 Gene

Suggested Antigen Peptide Sequences for CBR1 Gene

Graphical View of Domain Structure for InterPro Entry

P16152

UniProtKB/Swiss-Prot:

CBR1_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with CBR1: view

Function for CBR1 Gene

Molecular function for CBR1 Gene

GENATLAS Biochemistry:
carbonyl reductase,NADPH-dependent oxidoreductase,cytosolic,involved in the metabolism of many carbonyl compounds,including antitumor anthracyne antibiotics
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=30 uM for S-nitrosoglutathione {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=22 uM for menadione {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=309 uM for prostaglandin E2 {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=173 uM for daunorubicin {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=247 uM for NADPH {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943};
UniProtKB/Swiss-Prot CatalyticActivity:
R-CHOH-R + NADP(+) = R-CO-R + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity:
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity:
(13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by quercetin, rutenin and its derivatives.
UniProtKB/Swiss-Prot Function:
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

Enzyme Numbers (IUBMB) for CBR1 Gene

Gene Ontology (GO) - Molecular Function for CBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004090 carbonyl reductase (NADPH) activity IDA 18449627
GO:0016491 oxidoreductase activity IEA --
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA 19442656
GO:0047021 15-hydroxyprostaglandin dehydrogenase (NADP+) activity IEA --
GO:0050221 prostaglandin-E2 9-reductase activity TAS --
genes like me logo Genes that share ontologies with CBR1: view
genes like me logo Genes that share phenotypes with CBR1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CBR1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBR1 Gene

Localization for CBR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBR1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CBR1 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
GO:1903561 extracellular vesicle IDA 24769233
genes like me logo Genes that share ontologies with CBR1: view

Pathways & Interactions for CBR1 Gene

genes like me logo Genes that share pathways with CBR1: view

Gene Ontology (GO) - Biological Process for CBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017144 drug metabolic process IDA 18449627
GO:0019371 cyclooxygenase pathway TAS --
GO:0030855 epithelial cell differentiation IEP 21492153
GO:0042373 vitamin K metabolic process IDA 18449627
GO:0055114 oxidation-reduction process IEA,IDA 19442656
genes like me logo Genes that share ontologies with CBR1: view

No data available for SIGNOR curated interactions for CBR1 Gene

Drugs & Compounds for CBR1 Gene

(19) Drugs for CBR1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxorubicin Approved, Investigational Pharma Enzyme, substrate Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1751
Haloperidol Approved Pharma Antagonist, Enzyme, substrate Antipsychotic drug 147
Lubiprostone Approved, Investigational Pharma Activator, Enzyme, substrate 46
Deutetrabenazine Approved, Investigational Pharma Enzyme, substrate 0
Tetrabenazine Approved Pharma Inhibition, Inhibitor, Enzyme, substrate Potent inhibitor of vesicular monoamine transport 16

(14) Additional Compounds for CBR1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
(13E)-11a-Hydroxy-9,15-dioxoprost-13-enoic acid
  • (11a,13E)-11-hydroxy-9,15-dioxoprost-13-en-1-oate
  • (11a,13E)-11-hydroxy-9,15-dioxoprost-13-en-1-oic acid
  • (11alpha,13E)-11-hydroxy-9,15-dioxoprost-13-en-1-oate
  • (11alpha,13E)-11-hydroxy-9,15-dioxoprost-13-en-1-oic acid
  • (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate
22973-19-9
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
  • NNAL
76014-81-8
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
  • 4-(Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
  • 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
  • 4-(Methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
  • 4-(Methylnitrosoamino)-1-(3-pyridyl)-1-butanone
  • 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
64091-91-4
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton

(1) ApexBio Compounds for CBR1 Gene

Compound Action Cas Number
N6022 GSNOR inhibitor 1208315-24-5
genes like me logo Genes that share compounds with CBR1: view

Drug Products

Transcripts for CBR1 Gene

Unigene Clusters for CBR1 Gene

Carbonyl reductase 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CBR1

Alternative Splicing Database (ASD) splice patterns (SP) for CBR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for CBR1 Gene

GeneLoc Exon Structure for
CBR1
ECgene alternative splicing isoforms for
CBR1

Expression for CBR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CBR1 Gene

Protein differential expression in normal tissues from HIPED for CBR1 Gene

This gene is overexpressed in Liver, secretome (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CBR1 Gene



Protein tissue co-expression partners for CBR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CBR1 Gene:

CBR1

SOURCE GeneReport for Unigene cluster for CBR1 Gene:

Hs.88778

Evidence on tissue expression from TISSUES for CBR1 Gene

  • Nervous system(4.9)
  • Skin(4.4)
  • Liver(3.2)
  • Kidney(2.3)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with CBR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBR1 Gene

Orthologs for CBR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CBR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CBR1 34 35
  • 99.04 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 88 (a)
OneToMany
CBR1 34
  • 86.4 (n)
MGC127133 35
  • 78 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 88 (a)
OneToMany
LOC610164 34
  • 86.88 (n)
-- 35
  • 79 (a)
OneToMany
-- 35
  • 74 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cbr1 34 16 35
  • 83.87 (n)
rat
(Rattus norvegicus)
Mammalia Cbr1 34
  • 83.63 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 83 (a)
ManyToMany
-- 35
  • 82 (a)
ManyToMany
-- 35
  • 73 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves CBR1 34 35
  • 72.12 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 77 (a)
ManyToMany
-- 35
  • 75 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cbr3 34
  • 71.83 (n)
Str.11980 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.21423 34
zebrafish
(Danio rerio)
Actinopterygii cbr1 34 35
  • 64.48 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9689 34
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G61830 34
  • 46.04 (n)
rice
(Oryza sativa)
Liliopsida Os01g0929500 34
  • 49.62 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1580 34
Species where no ortholog for CBR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBR1 Gene

ENSEMBL:
Gene Tree for CBR1 (if available)
TreeFam:
Gene Tree for CBR1 (if available)

Paralogs for CBR1 Gene

Paralogs for CBR1 Gene

(1) SIMAP similar genes for CBR1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CBR1 Gene

genes like me logo Genes that share paralogs with CBR1: view

Variants for CBR1 Gene

Sequence variations from dbSNP and Humsavar for CBR1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000335693 -- 36,070,386(+) ACAAC(A/G)CGGGC nc-transcript-variant, reference, missense
rs1000643873 -- 36,071,386(+) CCCTT(G/T)CTCTG intron-variant
rs1000673305 -- 36,071,663(+) TAATC(A/G)TTTAC intron-variant
rs1000857332 -- 36,073,350(+) CACAT(A/T)ATGTA intron-variant, downstream-variant-500B
rs1002191556 -- 36,071,189(+) CTCCT(C/G)CCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CBR1 Gene

Variant ID Type Subtype PubMed ID
esv2751927 CNV gain 17911159
nsv459247 CNV loss 19166990
nsv470899 CNV loss 18288195
nsv587461 CNV loss 21841781
nsv964547 CNV deletion 23825009

Variation tolerance for CBR1 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CBR1 Gene

Human Gene Mutation Database (HGMD)
CBR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CBR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBR1 Gene

Disorders for CBR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CBR1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 58
  • rp58
- elite association - COSMIC cancer census association via MalaCards
Search CBR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CBR1

Genetic Association Database (GAD)
CBR1
Human Genome Epidemiology (HuGE) Navigator
CBR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBR1
genes like me logo Genes that share disorders with CBR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CBR1 Gene

Publications for CBR1 Gene

  1. Pharmacogenetics of human carbonyl reductase 1 (CBR1) in livers from black and white donors. (PMID: 19022938) Gonzalez-Covarrubias V. … Blanco J.G. (Drug Metab. Dispos. 2009) 3 22 46 64
  2. CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients. (PMID: 19016765) Lal S. … Chowbay B. (Cancer Sci. 2008) 3 22 46 64
  3. Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER). (PMID: 18449627) Gonzalez-Covarrubias V. … Blanco J.G. (Pharm. Res. 2008) 3 4 22 64
  4. Human carbonyl reductase 1 is an S-nitrosoglutathione reductase. (PMID: 18826943) Bateman R.L. … Shokat K.M. (J. Biol. Chem. 2008) 3 4 22 64
  5. A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity. (PMID: 17344335) Gonzalez-Covarrubias V. … Blanco J.G. (Drug Metab. Dispos. 2007) 3 4 22 64

Products for CBR1 Gene

  • Addgene plasmids for CBR1

Sources for CBR1 Gene

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