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Aliases for CBR1 Gene

Aliases for CBR1 Gene

  • Carbonyl Reductase 1 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 21C Member 1 3 4
  • NADPH-Dependent Carbonyl Reductase 1 3 4
  • Prostaglandin-E(2) 9-Reductase 3 4
  • Prostaglandin 9-Ketoreductase 3 4
  • EC 1.1.1.184 4 63
  • SDR21C1 3 4
  • CBR 3 4
  • Short Chain Dehydrogenase/Reductase Family 21C, Member 1 3
  • 15-Hydroxyprostaglandin Dehydrogenase [NADP(+)] 4
  • Short Chain Dehydrogenase/Reductase Family 21C 2
  • 15-Hydroxyprostaglandin Dehydrogenase 3
  • Carbonyl Reductase (NADPH) 1 3
  • EC 1.1.1.197 4
  • EC 1.1.1.189 4
  • Member 1 2
  • HCBR1 3
  • CRN 4

External Ids for CBR1 Gene

Previous HGNC Symbols for CBR1 Gene

  • CBR

Previous GeneCards Identifiers for CBR1 Gene

  • GC21P034019
  • GC21P036362
  • GC21P036364
  • GC21P037442
  • GC21P022920

Summaries for CBR1 Gene

Entrez Gene Summary for CBR1 Gene

  • The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for CBR1 Gene

CBR1 (Carbonyl Reductase 1) is a Protein Coding gene. Diseases associated with CBR1 include preeclampsia/eclampsia 5. Among its related pathways are Linoleic acid metabolism and Metabolism of xenobiotics by cytochrome P450. GO annotations related to this gene include oxidoreductase activity and carbonyl reductase (NADPH) activity. An important paralog of this gene is CBR3.

UniProtKB/Swiss-Prot for CBR1 Gene

  • NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

Gene Wiki entry for CBR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBR1 Gene

Genomics for CBR1 Gene

Regulatory Elements for CBR1 Gene

Enhancers for CBR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CBR1 on UCSC Golden Path with GeneCards custom track

Promoters for CBR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CBR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CBR1 Gene

Chromosome:
21
Start:
36,069,924 bp from pter
End:
36,073,177 bp from pter
Size:
3,254 bases
Orientation:
Plus strand

Genomic View for CBR1 Gene

Genes around CBR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBR1 Gene

Proteins for CBR1 Gene

  • Protein details for CBR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16152-CBR1_HUMAN
    Recommended name:
    Carbonyl reductase [NADPH] 1
    Protein Accession:
    P16152
    Secondary Accessions:
    • B2RBZ7
    • B4DFK7
    • Q3LHW8

    Protein attributes for CBR1 Gene

    Size:
    277 amino acids
    Molecular mass:
    30375 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CBR1 Gene

    Alternative splice isoforms for CBR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CBR1 Gene

Proteomics data for CBR1 Gene at MOPED

Post-translational modifications for CBR1 Gene

  • Ubiquitination at Lys 174 and Lys 186
  • Modification sites at PhosphoSitePlus

Other Protein References for CBR1 Gene

Domains & Families for CBR1 Gene

Gene Families for CBR1 Gene

Suggested Antigen Peptide Sequences for CBR1 Gene

Graphical View of Domain Structure for InterPro Entry

P16152

UniProtKB/Swiss-Prot:

CBR1_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with CBR1: view

Function for CBR1 Gene

Molecular function for CBR1 Gene

GENATLAS Biochemistry:
carbonyl reductase,NADPH-dependent oxidoreductase,cytosolic,involved in the metabolism of many carbonyl compounds,including antitumor anthracyne antibiotics
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=30 uM for S-nitrosoglutathione {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=22 uM for menadione {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=309 uM for prostaglandin E2 {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=173 uM for daunorubicin {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=247 uM for NADPH {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943};
UniProtKB/Swiss-Prot CatalyticActivity:
R-CHOH-R + NADP(+) = R-CO-R + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity:
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity:
(13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by quercetin, rutenin and its derivatives.
UniProtKB/Swiss-Prot Function:
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

Enzyme Numbers (IUBMB) for CBR1 Gene

Gene Ontology (GO) - Molecular Function for CBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004090 carbonyl reductase (NADPH) activity IDA 18449627
genes like me logo Genes that share ontologies with CBR1: view
genes like me logo Genes that share phenotypes with CBR1: view

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBR1 Gene

Localization for CBR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBR1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBR1 Gene COMPARTMENTS Subcellular localization image for CBR1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CBR1 Gene

Pathways & Interactions for CBR1 Gene

genes like me logo Genes that share pathways with CBR1: view

Gene Ontology (GO) - Biological Process for CBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0019371 cyclooxygenase pathway TAS --
GO:0030855 epithelial cell differentiation IEP 21492153
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA,IDA 19442656
genes like me logo Genes that share ontologies with CBR1: view

No data available for SIGNOR curated interactions for CBR1 Gene

Drugs & Compounds for CBR1 Gene

(18) Drugs for CBR1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxorubicin Approved, Investigational Pharma Enzyme, substrate Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1649
Haloperidol Approved Pharma Antagonist, Enzyme, substrate Antipsychotic drug 136
Lubiprostone Approved, Investigational Pharma Activator, Enzyme, substrate 44
Tetrabenazine Approved Pharma Inhibition, Inhibitor, Enzyme, substrate Potent inhibitor of vesicular monoamine transport 16
Doxil Approved June 1999 Pharma DNA intercalator and TOPO II inhibitor, Topoisomerase 2 Inhibitors 1649

(14) Additional Compounds for CBR1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
(13E)-11a-Hydroxy-9,15-dioxoprost-13-enoic acid
  • (11a,13E)-11-hydroxy-9,15-dioxoprost-13-en-1-oate
  • (11a,13E)-11-hydroxy-9,15-dioxoprost-13-en-1-oic acid
  • (11alpha,13E)-11-hydroxy-9,15-dioxoprost-13-en-1-oate
  • (11alpha,13E)-11-hydroxy-9,15-dioxoprost-13-en-1-oic acid
  • (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate
22973-19-9
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
  • NNAL
76014-81-8
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
  • 4-(Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
  • 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
  • 4-(Methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
  • 4-(Methylnitrosoamino)-1-(3-pyridyl)-1-butanone
  • 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
64091-91-4
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton

(1) ApexBio Compounds for CBR1 Gene

Compound Action Cas Number
N6022 GSNOR inhibitor 1208315-24-5
genes like me logo Genes that share compounds with CBR1: view

Transcripts for CBR1 Gene

Unigene Clusters for CBR1 Gene

Carbonyl reductase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CBR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for CBR1 Gene

GeneLoc Exon Structure for
CBR1
ECgene alternative splicing isoforms for
CBR1

Expression for CBR1 Gene

mRNA expression in normal human tissues for CBR1 Gene

Protein differential expression in normal tissues from HIPED for CBR1 Gene

This gene is overexpressed in Liver, secretome (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CBR1 Gene



SOURCE GeneReport for Unigene cluster for CBR1 Gene Hs.88778

genes like me logo Genes that share expression patterns with CBR1: view

Protein tissue co-expression partners for CBR1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CBR1 Gene

Orthologs for CBR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CBR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CBR1 35
  • 86.4 (n)
  • 88.81 (a)
-- 36
  • 88 (a)
OneToMany
MGC127133 36
  • 78 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC610164 35
  • 86.88 (n)
  • 88.45 (a)
-- 36
  • 88 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cbr1 35
  • 83.87 (n)
  • 87.73 (a)
Cbr1 16
Cbr1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CBR1 35
  • 99.04 (n)
  • 100 (a)
CBR1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cbr1 35
  • 83.63 (n)
  • 85.92 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
ManyToMany
-- 36
  • 83 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves CBR1 35
  • 72.12 (n)
  • 78.55 (a)
CBR1 36
  • 78 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 75 (a)
ManyToMany
-- 36
  • 77 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cbr3 35
  • 71.83 (n)
  • 75.65 (a)
Str.11980 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.21423 35
zebrafish
(Danio rerio)
Actinopterygii cbr1 35
  • 64.48 (n)
  • 66.18 (a)
cbr1 36
  • 66 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9689 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G61830 35
  • 46.04 (n)
  • 40 (a)
rice
(Oryza sativa)
Liliopsida Os01g0929500 35
  • 49.62 (n)
  • 39.39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1580 35
Species with no ortholog for CBR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBR1 Gene

ENSEMBL:
Gene Tree for CBR1 (if available)
TreeFam:
Gene Tree for CBR1 (if available)

Paralogs for CBR1 Gene

Paralogs for CBR1 Gene

(1) SIMAP similar genes for CBR1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CBR1 Gene

genes like me logo Genes that share paralogs with CBR1: view

Variants for CBR1 Gene

Sequence variations from dbSNP and Humsavar for CBR1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
VAR_031706 -
VAR_059053 -
rs757483525 -- 36,069,070(+) AACTC(-/CTG)CTATT upstream-variant-2KB
rs576964020 -- 36,069,086(+) CCACA(G/T)GCAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CBR1 Gene

Variant ID Type Subtype PubMed ID
nsv913730 CNV Gain 21882294
nsv470899 CNV Loss 18288195
nsv459247 CNV Loss 19166990
esv2751927 CNV Gain 17911159

Variation tolerance for CBR1 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CBR1 Gene

HapMap Linkage Disequilibrium report
CBR1
Human Gene Mutation Database (HGMD)
CBR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBR1 Gene

Disorders for CBR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CBR1 Gene - From: OMIM

Disorder Aliases PubMed IDs
preeclampsia/eclampsia 5
  • gestational proteinuric hypertension
- elite association - COSMIC cancer census association via MalaCards
Search CBR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CBR1

Genetic Association Database (GAD)
CBR1
Human Genome Epidemiology (HuGE) Navigator
CBR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBR1
genes like me logo Genes that share disorders with CBR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CBR1 Gene

Publications for CBR1 Gene

  1. Pharmacogenetics of human carbonyl reductase 1 (CBR1) in livers from black and white donors. (PMID: 19022938) Gonzalez-Covarrubias V. … Blanco J.G. (Drug Metab. Dispos. 2009) 3 23 48 67
  2. Human carbonyl reductase (CBR) localized to band 21q22.1 by high-resolution fluorescence in situ hybridization displays gene dosage effects in trisomy 21 cells. (PMID: 8432528) Lemieux N. … Forrest G.L. (Genomics 1993) 2 3 23
  3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  4. Two nonsynonymous single nucleotide polymorphisms of human carbonyl reductase 1 demonstrate reduced in vitro metabolism of daunorubicin and doxorubicin. (PMID: 19204081) Bains O.S. … Riggs K.W. (Drug Metab. Dispos. 2009) 3 23
  5. Structural basis for substrate specificity in human monomeric carbonyl reductases. (PMID: 19841672) Pilka E.S. … Oppermann U. (PLoS ONE 2009) 3 23

Products for CBR1 Gene

Sources for CBR1 Gene

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