Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CBLN4 Gene

Aliases for CBLN4 Gene

  • Cerebellin 4 Precursor 2 3
  • Cerebellin-Like Glycoprotein 1 3 4
  • Cerebellin Precursor-Like 1 2 3
  • CBLNL1 3 4
  • Cerebellin-4 3

External Ids for CBLN4 Gene

Previous Symbols for CBLN4 Gene

  • CBLNL1

Summaries for CBLN4 Gene

Entrez Gene Summary for CBLN4 Gene

  • This gene encodes a member of a family of small secreted proteins containing C1Q domains. Members of this family are involved in regulation of neurexin signalling during synapse development. The mouse homolog of the protein encoded by this gene competes with netrin to bind to the deleted in colorectal cancer receptor. [provided by RefSeq, Aug 2012]

GeneCards Summary for CBLN4 Gene

CBLN4 (Cerebellin 4 Precursor) is a Protein Coding gene. Diseases associated with CBLN4 include colorectal cancer. An important paralog of this gene is C1QL4.

UniProtKB/Swiss-Prot for CBLN4 Gene

  • May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBLN4 Gene

Genomics for CBLN4 Gene

Genomic Location for CBLN4 Gene

Start:
55,997,357 bp from pter
End:
56,005,472 bp from pter
Size:
8,116 bases
Orientation:
Minus strand

Genomic View for CBLN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CBLN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBLN4 Gene

Regulatory Elements for CBLN4 Gene

Proteins for CBLN4 Gene

  • Protein details for CBLN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTU7-CBLN4_HUMAN
    Recommended name:
    Cerebellin-4
    Protein Accession:
    Q9NTU7
    Secondary Accessions:
    • A8K0S5

    Protein attributes for CBLN4 Gene

    Size:
    201 amino acids
    Molecular mass:
    21808 Da
    Quaternary structure:
    • Homohexamer; disulfide-linked homotrimers. The trimers are assembled via the globular C1q domains. The trimers associate via N-terminal cysteine residues to form disulfide-linked hexamers (By similarity). May form oligomers with CBLN1, CBLN2 and CBLN3 prior to secretion (By similarity). Strongly interacts with DCC in a NTN1-displaceable fashion (By similarity). Weakly binds to NRXN1 and NRXN2 long and short isoforms produced by alternative promoter usage. Interaction with NRXN3 short isoform is hardly detectable; no interaction at all with NRXN3 long isoform (By similarity).

neXtProt entry for CBLN4 Gene

Proteomics data for CBLN4 Gene at MOPED

Post-translational modifications for CBLN4 Gene

Other Protein References for CBLN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CBLN4 Gene

Domains for CBLN4 Gene

Protein Domains for CBLN4 Gene

Suggested Antigen Peptide Sequences for CBLN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NTU7

UniProtKB/Swiss-Prot:

CBLN4_HUMAN
Domain:
  • Contains 1 C1q domain.:
    • Q9NTU7
genes like me logo Genes that share domains with CBLN4: view

No data available for Gene Families for CBLN4 Gene

Function for CBLN4 Gene

Molecular function for CBLN4 Gene

UniProtKB/Swiss-Prot Function: May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity).

Gene Ontology (GO) - Molecular Function for CBLN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CBLN4: view

Phenotypes for CBLN4 Gene

MGI mutant phenotypes for CBLN4:
inferred from 1 alleles
GenomeRNAi human phenotypes for CBLN4:
genes like me logo Genes that share phenotypes with CBLN4: view

Animal Models for CBLN4 Gene

MGI Knock Outs for CBLN4:

miRNA for CBLN4 Gene

miRTarBase miRNAs that target CBLN4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CBLN4 Gene

Localization for CBLN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBLN4 Gene

Secreted. Cell junction, synapse.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBLN4 Gene COMPARTMENTS Subcellular localization image for CBLN4 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CBLN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with CBLN4: view

Pathways for CBLN4 Gene

SuperPathways for CBLN4 Gene

No Data Available

Interacting Proteins for CBLN4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000064571%0d%0a9606.ENSP00000267406%0d%0a9606.ENSP00000377262%0d%0a
Selected Interacting proteins: ENSP00000064571 Q9NTU7-CBLN4_HUMAN for CBLN4 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CBLN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009306 protein secretion IEA --
genes like me logo Genes that share ontologies with CBLN4: view

No data available for Pathways by source for CBLN4 Gene

Transcripts for CBLN4 Gene

mRNA/cDNA for CBLN4 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CBLN4 Gene

Cerebellin 4 precursor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CBLN4 Gene

No ASD Table

Relevant External Links for CBLN4 Gene

GeneLoc Exon Structure for
CBLN4
ECgene alternative splicing isoforms for
CBLN4

Expression for CBLN4 Gene

mRNA expression in normal human tissues for CBLN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CBLN4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (9.6), Brain - Anterior cingulate cortex (BA24) (7.6), Brain - Hypothalamus (6.8), Brain - Cortex (6.2), and Brain - Amygdala (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CBLN4 Gene

SOURCE GeneReport for Unigene cluster for CBLN4 Gene Hs.126141

genes like me logo Genes that share expressions with CBLN4: view

No data available for mRNA Expression by UniProt/SwissProt for CBLN4 Gene

Orthologs for CBLN4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CBLN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CBLN4 35
  • 99.83 (n)
  • 100 (a)
CBLN4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CBLN4 35
  • 91.15 (n)
  • 100 (a)
CBLN4 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CBLN4 35
  • 93.2 (n)
  • 98.01 (a)
CBLN4 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cbln4 35
  • 88.89 (n)
  • 97.47 (a)
Cbln4 16
Cbln4 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CBLN4 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CBLN4 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cbln4 35
  • 88.55 (n)
  • 97.98 (a)
chicken
(Gallus gallus)
Aves CBLN4 35
  • 86.91 (n)
  • 93.72 (a)
CBLN4 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CBLN4 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64424 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cbln4 35
  • 76.63 (n)
  • 92.78 (a)
zebrafish
(Danio rerio)
Actinopterygii cbln4 35
  • 75.25 (n)
  • 86.87 (a)
cbln4 36
  • 83 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for CBLN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBLN4 Gene

ENSEMBL:
Gene Tree for CBLN4 (if available)
TreeFam:
Gene Tree for CBLN4 (if available)

Paralogs for CBLN4 Gene

Selected SIMAP similar genes for CBLN4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CBLN4: view

Variants for CBLN4 Gene

Sequence variations from dbSNP and Humsavar for CBLN4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs415364 -- 56,003,119(-) GCTGG(G/T)GAAAG intron-variant
rs422330 -- 56,003,787(-) GATTG(C/G)GAAAT intron-variant
rs878428 -- 56,007,270(+) CTCTC(G/T)CAGTA upstream-variant-2KB
rs878429 -- 56,006,971(+) TGACa(A/C)aaaaa upstream-variant-2KB
rs6014571 -- 55,997,030(+) TATGA(A/G)AATAT downstream-variant-500B

Relevant External Links for CBLN4 Gene

HapMap Linkage Disequilibrium report
CBLN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CBLN4 Gene

Disorders for CBLN4 Gene

(1) MalaCards Diseases for CBLN4 Gene

Search for CBLN4 Gene in MalaCards »

Relevant External Links for CBLN4

Genetic Association Database (GAD)
CBLN4
genes like me logo Genes that share disorders with CBLN4: view

No data available for UniProtKB/Swiss-Prot for CBLN4 Gene

Publications for CBLN4 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Precerebellin-related genes and precerebellin 1 peptide in the adrenal gland of the rat: expression pattern, localization, developmental regulation and effects on corticosteroidogenesis. (PMID: 19212655) Rucinski M. … Malendowicz L.K. (Int. J. Mol. Med. 2009) 3 23
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for CBLN4 Gene

Sources for CBLN4 Gene

Back to Top

Content