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Aliases for CBLN4 Gene

Aliases for CBLN4 Gene

  • Cerebellin 4 Precursor 2 3 5
  • Cerebellin-Like Glycoprotein 1 3 4
  • Cerebellin Precursor-Like 1 2 3
  • CBLNL1 3 4

External Ids for CBLN4 Gene

Previous HGNC Symbols for CBLN4 Gene

  • CBLNL1

Previous GeneCards Identifiers for CBLN4 Gene

  • GC20M054005
  • GC20M054572
  • GC20M051353

Summaries for CBLN4 Gene

Entrez Gene Summary for CBLN4 Gene

  • This gene encodes a member of a family of small secreted proteins containing C1Q domains. Members of this family are involved in regulation of neurexin signalling during synapse development. The mouse homolog of the protein encoded by this gene competes with netrin to bind to the deleted in colorectal cancer receptor. [provided by RefSeq, Aug 2012]

GeneCards Summary for CBLN4 Gene

CBLN4 (Cerebellin 4 Precursor) is a Protein Coding gene. An important paralog of this gene is C1QL4.

UniProtKB/Swiss-Prot for CBLN4 Gene

  • May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBLN4 Gene

Genomics for CBLN4 Gene

Regulatory Elements for CBLN4 Gene

Genomic Location for CBLN4 Gene

Chromosome:
20
Start:
55,997,357 bp from pter
End:
56,005,474 bp from pter
Size:
8,118 bases
Orientation:
Minus strand

Genomic View for CBLN4 Gene

Genes around CBLN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBLN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBLN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBLN4 Gene

Proteins for CBLN4 Gene

  • Protein details for CBLN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTU7-CBLN4_HUMAN
    Recommended name:
    Cerebellin-4
    Protein Accession:
    Q9NTU7
    Secondary Accessions:
    • A8K0S5

    Protein attributes for CBLN4 Gene

    Size:
    201 amino acids
    Molecular mass:
    21808 Da
    Quaternary structure:
    • Homohexamer; disulfide-linked homotrimers. The trimers are assembled via the globular C1q domains. The trimers associate via N-terminal cysteine residues to form disulfide-linked hexamers (By similarity). May form oligomers with CBLN1, CBLN2 and CBLN3 prior to secretion (By similarity). Strongly interacts with DCC in a NTN1-displaceable fashion (By similarity). Weakly binds to NRXN1 and NRXN2 long and short isoforms produced by alternative promoter usage. Interaction with NRXN3 short isoform is hardly detectable; no interaction at all with NRXN3 long isoform (By similarity).

neXtProt entry for CBLN4 Gene

Proteomics data for CBLN4 Gene at MOPED

Post-translational modifications for CBLN4 Gene

  • Glycosylation at Asn 29 and Asn 88
  • Modification sites at PhosphoSitePlus

Other Protein References for CBLN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CBLN4 Gene

Domains & Families for CBLN4 Gene

Protein Domains for CBLN4 Gene

Suggested Antigen Peptide Sequences for CBLN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NTU7

UniProtKB/Swiss-Prot:

CBLN4_HUMAN :
  • Contains 1 C1q domain.
Domain:
  • Contains 1 C1q domain.
genes like me logo Genes that share domains with CBLN4: view

No data available for Gene Families for CBLN4 Gene

Function for CBLN4 Gene

Molecular function for CBLN4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity).
genes like me logo Genes that share phenotypes with CBLN4: view

Animal Models for CBLN4 Gene

MGI Knock Outs for CBLN4:

Animal Model Products

  • Taconic Biosciences Mouse Models for CBLN4

miRNA for CBLN4 Gene

miRTarBase miRNAs that target CBLN4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBLN4 Gene

Localization for CBLN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBLN4 Gene

Secreted. Cell junction, synapse.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBLN4 Gene COMPARTMENTS Subcellular localization image for CBLN4 gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for CBLN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with CBLN4: view

Pathways & Interactions for CBLN4 Gene

SuperPathways for CBLN4 Gene

No Data Available

Interacting Proteins for CBLN4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000064571%0d%0a9606.ENSP00000267406%0d%0a9606.ENSP00000377262%0d%0a
Selected Interacting proteins: ENSP00000064571 Q9NTU7-CBLN4_HUMAN for CBLN4 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CBLN4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CBLN4 Gene

Drugs & Compounds for CBLN4 Gene

No Compound Related Data Available

Transcripts for CBLN4 Gene

mRNA/cDNA for CBLN4 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CBLN4 Gene

Cerebellin 4 precursor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CBLN4 Gene

No ASD Table

Relevant External Links for CBLN4 Gene

GeneLoc Exon Structure for
CBLN4
ECgene alternative splicing isoforms for
CBLN4

Expression for CBLN4 Gene

mRNA expression in normal human tissues for CBLN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CBLN4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.6), Brain - Anterior cingulate cortex (BA24) (x7.6), Brain - Hypothalamus (x6.8), Brain - Cortex (x6.2), and Brain - Amygdala (x4.8).

Protein differential expression in normal tissues from HIPED for CBLN4 Gene

This gene is overexpressed in Plasma (32.8) and Cerebrospinal fluid (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CBLN4 Gene



SOURCE GeneReport for Unigene cluster for CBLN4 Gene Hs.126141

genes like me logo Genes that share expression patterns with CBLN4: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CBLN4 Gene

Orthologs for CBLN4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CBLN4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CBLN4 35
  • 91.15 (n)
  • 100 (a)
CBLN4 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CBLN4 35
  • 93.2 (n)
  • 98.01 (a)
CBLN4 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cbln4 35
  • 88.89 (n)
  • 97.47 (a)
Cbln4 16
Cbln4 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CBLN4 35
  • 99.83 (n)
  • 100 (a)
CBLN4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cbln4 35
  • 88.55 (n)
  • 97.98 (a)
oppossum
(Monodelphis domestica)
Mammalia CBLN4 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CBLN4 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves CBLN4 35
  • 86.91 (n)
  • 93.72 (a)
CBLN4 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CBLN4 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cbln4 35
  • 76.63 (n)
  • 92.78 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC64424 35
zebrafish
(Danio rerio)
Actinopterygii cbln4 35
  • 75.25 (n)
  • 86.87 (a)
cbln4 36
  • 83 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for CBLN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBLN4 Gene

ENSEMBL:
Gene Tree for CBLN4 (if available)
TreeFam:
Gene Tree for CBLN4 (if available)

Paralogs for CBLN4 Gene

(4) SIMAP similar genes for CBLN4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CBLN4: view

Variants for CBLN4 Gene

Sequence variations from dbSNP and Humsavar for CBLN4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs415364 -- 56,003,119(-) GCTGG(G/T)GAAAG intron-variant
rs422330 -- 56,003,787(-) GATTG(C/G)GAAAT intron-variant
rs878428 -- 56,007,270(+) CTCTC(G/T)CAGTA upstream-variant-2KB
rs6014571 -- 55,997,030(+) TATGA(A/G)AATAT downstream-variant-500B
rs6014572 -- 55,999,488(+) GCCTG(A/G)TTGGT intron-variant

Variation tolerance for CBLN4 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CBLN4 Gene

HapMap Linkage Disequilibrium report
CBLN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CBLN4 Gene

Disorders for CBLN4 Gene

Relevant External Links for CBLN4

Genetic Association Database (GAD)
CBLN4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBLN4

No disorders were found for CBLN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBLN4 Gene

Publications for CBLN4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Precerebellin-related genes and precerebellin 1 peptide in the adrenal gland of the rat: expression pattern, localization, developmental regulation and effects on corticosteroidogenesis. (PMID: 19212655) Rucinski M. … Malendowicz L.K. (Int. J. Mol. Med. 2009) 3 23
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  4. Glutamate receptor I'1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes. (PMID: 22191730) Yasumura M. … Mishina M. (J. Neurochem. 2012) 3
  5. The Cbln family of proteins interact with multiple signaling pathways. (PMID: 22220752) Wei P. … Morgan J.I. (J. Neurochem. 2012) 3

Products for CBLN4 Gene

Sources for CBLN4 Gene

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