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CBLN4 Gene(Protein Coding)

Cerebellin 4 Precursor

GCID:
GC20M055997
GIFtS:
47
Genes Participants
UDN Logo

Aliases for CBLN4 Gene

Aliases for CBLN4 Gene

  • Cerebellin 4 Precursor 2 3 5
  • Cerebellin-Like Glycoprotein 1 3 4
  • Cerebellin Precursor-Like 1 2 3
  • CBLNL1 3 4
  • Cerebellin-4 3

External Ids for CBLN4 Gene

Previous HGNC Symbols for CBLN4 Gene

  • CBLNL1

Previous GeneCards Identifiers for CBLN4 Gene

  • GC20M054005
  • GC20M054572
  • GC20M051353

Summaries for CBLN4 Gene

Entrez Gene Summary for CBLN4 Gene

  • This gene encodes a member of a family of small secreted proteins containing C1Q domains. Members of this family are involved in regulation of neurexin signalling during synapse development. The mouse homolog of the protein encoded by this gene competes with netrin to bind to the deleted in colorectal cancer receptor. [provided by RefSeq, Aug 2012]

GeneCards Summary for CBLN4 Gene

CBLN4 (Cerebellin 4 Precursor) is a Protein Coding gene. An important paralog of this gene is CBLN2.

UniProtKB/Swiss-Prot for CBLN4 Gene

  • May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBLN4 Gene

Genomics for CBLN4 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CBLN4 Gene


Transcription factor binding sites by QIAGEN in the CBLN4 gene promoter:

Genomic Location for CBLN4 Gene

Chromosome:
20
Start:
55,997,357 bp from pter
End:
56,005,474 bp from pter
Size:
8,118 bases
Orientation:
Minus strand

Genomic View for CBLN4 Gene

Genes around CBLN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBLN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBLN4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CBLN4 Gene

Proteins for CBLN4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CBLN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTU7-CBLN4_HUMAN
    Recommended name:
    Cerebellin-4
    Protein Accession:
    Q9NTU7
    Secondary Accessions:
    • A8K0S5

    Protein attributes for CBLN4 Gene

    Size:
    201 amino acids
    Molecular mass:
    21808 Da
    Quaternary structure:
    • Homohexamer; disulfide-linked homotrimers. The trimers are assembled via the globular C1q domains. The trimers associate via N-terminal cysteine residues to form disulfide-linked hexamers (By similarity). May form oligomers with CBLN1, CBLN2 and CBLN3 prior to secretion (By similarity). Strongly interacts with DCC in a NTN1-displaceable fashion (By similarity). Weakly binds to NRXN1 and NRXN2 long and short isoforms produced by alternative promoter usage. Interaction with NRXN3 short isoform is hardly detectable; no interaction at all with NRXN3 long isoform (By similarity).

neXtProt entry for CBLN4 Gene

Protein Expression for CBLN4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CBLN4 Gene

  • Glycosylation at posLast=2929 and Asn88
  • Modification sites at PhosphoSitePlus

Other Protein References for CBLN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CBLN4 Gene

Domains & Families for CBLN4 Gene

Protein Domains for CBLN4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CBLN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CBLN4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CBLN4 Gene

Function for CBLN4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CBLN4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity).
genes like me logo Genes that share phenotypes with CBLN4: view

Animal Models for CBLN4 Gene

MGI Knock Outs for CBLN4:

Animal Model Products

  • Taconic Biosciences Mouse Models for CBLN4

miRNA for CBLN4 Gene

miRTarBase miRNAs that target CBLN4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBLN4 Gene

Localization for CBLN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBLN4 Gene

Secreted. Cell junction, synapse.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CBLN4 gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for CBLN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with CBLN4: view

Pathways & Interactions for CBLN4 Gene

SuperPathways for CBLN4 Gene

PathCards logo More details on SuperPathways for CBLN4
No Data Available

Interacting Proteins for CBLN4 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000064571%0d%0a9606.ENSP00000267406%0d%0a9606.ENSP00000358739%0d%0a9606.ENSP00000377262%0d%0a
Selected Interacting proteins: ENSP00000064571 Q9NTU7-CBLN4_HUMAN for CBLN4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CBLN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009306 protein secretion IEA --
genes like me logo Genes that share ontologies with CBLN4: view

No data available for Pathways by source and SIGNOR curated interactions for CBLN4 Gene

Drugs & Compounds for CBLN4 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CBLN4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CBLN4 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CBLN4 Gene

Cerebellin 4 precursor:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CBLN4 Gene

No ASD Table

Relevant External Links for CBLN4 Gene

GeneLoc Exon Structure for
CBLN4
ECgene alternative splicing isoforms for
CBLN4

Expression for CBLN4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CBLN4 Gene

mRNA expression in normal human tissues for CBLN4 Gene
mRNA expression by BioGPS for CBLN4 GenemRNA expression by GTEx for CBLN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CBLN4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.6), Brain - Anterior cingulate cortex (BA24) (x7.6), Brain - Hypothalamus (x6.8), Brain - Cortex (x6.2), and Brain - Amygdala (x4.8).

Protein differential expression in normal tissues from HIPED for CBLN4 Gene

This gene is overexpressed in Plasma (32.8) and Cerebrospinal fluid (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CBLN4 Gene



NURSA nuclear receptor signaling pathways regulating expression of CBLN4 Gene:

CBLN4

SOURCE GeneReport for Unigene cluster for CBLN4 Gene:

Hs.126141

Evidence on tissue expression from TISSUES for CBLN4 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with CBLN4: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBLN4 Gene

Orthologs for CBLN4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CBLN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CBLN4 34 35
  • 99.83 (n)
dog
(Canis familiaris)
 Mammalia CBLN4 34 35
  • 93.2 (n)
cow
(Bos Taurus)
 Mammalia CBLN4 34 35
  • 91.15 (n)
mouse
(Mus musculus)
 Mammalia Cbln4 34 16 35
  • 88.89 (n)
rat
(Rattus norvegicus)
 Mammalia Cbln4 34
  • 88.55 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CBLN4 35
  • 82 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia CBLN4 35
  • 78 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CBLN4 34 35
  • 86.91 (n)
lizard
(Anolis carolinensis)
 Reptilia CBLN4 35
  • 94 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cbln4 34
  • 76.63 (n)
African clawed frog
(Xenopus laevis)
 Amphibia MGC64424 34
zebrafish
(Danio rerio)
 Actinopterygii cbln4 34 35
  • 75.25 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 35 (a)
 OneToMany
Species where no ortholog for CBLN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBLN4 Gene

ENSEMBL:
Gene Tree for CBLN4 (if available)
TreeFam:
Gene Tree for CBLN4 (if available)

Paralogs for CBLN4 Gene

Paralogs for CBLN4 Gene

(4) SIMAP similar genes for CBLN4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CBLN4: view

Variants for CBLN4 Gene

Sequence variations from dbSNP and Humsavar for CBLN4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000223400 -- 56,005,370(+) CAGGC(C/T)GGGTC utr-variant-5-prime
rs1000251847 -- 56,002,129(+) GCAGA(C/T)GTATC intron-variant
rs1000300008 -- 56,000,071(+) TATTA(A/G)CATAC intron-variant
rs1000351889 -- 55,999,768(+) CTATT(G/T)TCTAT intron-variant
rs1000572286 -- 56,005,531(+) CGTGG(A/G)GGCGG upstream-variant-2KB

Variation tolerance for CBLN4 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CBLN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CBLN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CBLN4 Gene

Disorders for CBLN4 Gene

Relevant External Links for CBLN4

Genetic Association Database (GAD)
CBLN4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBLN4

No disorders were found for CBLN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBLN4 Gene

Publications for CBLN4 Gene

  1. Precerebellin-related genes and precerebellin 1 peptide in the adrenal gland of the rat: expression pattern, localization, developmental regulation and effects on corticosteroidogenesis. (PMID: 19212655) Rucinski M. … Malendowicz L.K. (Int. J. Mol. Med. 2009) 3 22 64
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64

Products for CBLN4 Gene

Sources for CBLN4 Gene

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