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Aliases for CBLN3 Gene

Aliases for CBLN3 Gene

  • Cerebellin 3 Precursor 2 3
  • PRO1486 3

External Ids for CBLN3 Gene

Previous GeneCards Identifiers for CBLN3 Gene

  • GC00U907483
  • GC14U900191
  • GC14M023967
  • GC14M024895
  • GC14M005010

Summaries for CBLN3 Gene

Entrez Gene Summary for CBLN3 Gene

  • Members of the precerebellin family, such as CBLN3, contain a cerebellin motif (see CBLN1; MIM 600432) and a C-terminal C1q signature domain (see MIM 120550) that mediates trimeric assembly of atypical collagen complexes. However, precerebellins do not contain a collagen motif, suggesting that they are not conventional components of the extracellular matrix (Pang et al., 2000 [PubMed 10964938]).[supplied by OMIM, Aug 2009]

GeneCards Summary for CBLN3 Gene

CBLN3 (Cerebellin 3 Precursor) is a Protein Coding gene. An important paralog of this gene is C1QL4.

UniProtKB/Swiss-Prot for CBLN3 Gene

  • May be involved in synaptic functions in the CNS.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBLN3 Gene

Genomics for CBLN3 Gene

Regulatory Elements for CBLN3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CBLN3 Gene

Chromosome:
14
Start:
24,426,532 bp from pter
End:
24,430,954 bp from pter
Size:
4,423 bases
Orientation:
Minus strand

Genomic View for CBLN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CBLN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBLN3 Gene

Proteins for CBLN3 Gene

  • Protein details for CBLN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW01-CBLN3_HUMAN
    Recommended name:
    Cerebellin-3
    Protein Accession:
    Q6UW01

    Protein attributes for CBLN3 Gene

    Size:
    205 amino acids
    Molecular mass:
    21521 Da
    Quaternary structure:
    • Heterohexamer; disulfide-linked heterotrimers. Interacts with CBLN1. May also form oligomers with CBLN2 AND CBLN4 (By similarity).

neXtProt entry for CBLN3 Gene

Proteomics data for CBLN3 Gene at MOPED

Post-translational modifications for CBLN3 Gene

  • Glycosylation at Asn 90
  • Modification sites at PhosphoSitePlus

Other Protein References for CBLN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CBLN3 Gene

Domains & Families for CBLN3 Gene

Protein Domains for CBLN3 Gene

Suggested Antigen Peptide Sequences for CBLN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UW01

UniProtKB/Swiss-Prot:

CBLN3_HUMAN :
  • Contains 1 C1q domain.
Domain:
  • Contains 1 C1q domain.
genes like me logo Genes that share domains with CBLN3: view

No data available for Gene Families for CBLN3 Gene

Function for CBLN3 Gene

Molecular function for CBLN3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in synaptic functions in the CNS.

Gene Ontology (GO) - Molecular Function for CBLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CBLN3: view

Phenotypes for CBLN3 Gene

genes like me logo Genes that share phenotypes with CBLN3: view

Animal Models for CBLN3 Gene

MGI Knock Outs for CBLN3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CBLN3 Gene

Localization for CBLN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBLN3 Gene

Endoplasmic reticulum. Golgi apparatus, cis-Golgi network. Secreted. Cell junction, synapse. Note=In the absence of CBLN1, remains in the endoplasmic reticulum/cis-Golgi apparatus. Partial secretion depends on a association with CBLN1 and maybe CBLN4, but not on CBLN2 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBLN3 Gene COMPARTMENTS Subcellular localization image for CBLN3 gene
Compartment Confidence
endoplasmic reticulum 3
golgi apparatus 3
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CBLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with CBLN3: view

Pathways & Interactions for CBLN3 Gene

SuperPathways for CBLN3 Gene

No Data Available

Interacting Proteins for CBLN3 Gene

Gene Ontology (GO) - Biological Process for CBLN3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CBLN3 Gene

Drugs & Compounds for CBLN3 Gene

(3) Drugs for CBLN3 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Epinephrine Approved Pharma 768
Norepinephrine Approved Pharma 206
Corticosterone Pharma Endogenous glucocorticoid 9

(2) Additional Compounds for CBLN3 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CATECHOLAMINE
Steroid
genes like me logo Genes that share compounds with CBLN3: view

Transcripts for CBLN3 Gene

mRNA/cDNA for CBLN3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CBLN3 Gene

Cerebellin 3 precursor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CBLN3 Gene

No ASD Table

Relevant External Links for CBLN3 Gene

GeneLoc Exon Structure for
CBLN3
ECgene alternative splicing isoforms for
CBLN3

Expression for CBLN3 Gene

mRNA expression in normal human tissues for CBLN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CBLN3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x21.5) and Brain - Cerebellum (x19.5).

SOURCE GeneReport for Unigene cluster for CBLN3 Gene Hs.207603

genes like me logo Genes that share expression patterns with CBLN3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CBLN3 Gene

Orthologs for CBLN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CBLN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CBLN3 35
  • 89.11 (n)
  • 93.17 (a)
CBLN3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CBLN3 35
  • 89.59 (n)
  • 94.15 (a)
CBLN3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cbln3 35
  • 88.83 (n)
  • 97.16 (a)
Cbln3 16
Cbln3 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CBLN3 35
  • 98.86 (n)
  • 100 (a)
CBLN3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cbln3 35
  • 89.58 (n)
  • 97.16 (a)
oppossum
(Monodelphis domestica)
Mammalia CBLN3 36
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX664707.1 36
  • 55 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for CBLN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBLN3 Gene

ENSEMBL:
Gene Tree for CBLN3 (if available)
TreeFam:
Gene Tree for CBLN3 (if available)

Paralogs for CBLN3 Gene

(5) SIMAP similar genes for CBLN3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CBLN3: view

Variants for CBLN3 Gene

Variation tolerance for CBLN3 Gene

Residual Variation Intolerance Score: 62.09% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CBLN3 Gene

HapMap Linkage Disequilibrium report
CBLN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for CBLN3 Gene

Disorders for CBLN3 Gene

Relevant External Links for CBLN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBLN3
genes like me logo Genes that share disorders with CBLN3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBLN3 Gene

Publications for CBLN3 Gene

  1. Functional roles of neuropeptides in cerebellar circuits. (PMID: 19361475) Ito M. (Neuroscience 2009) 23 67
  2. Cerebellin in the rat adrenal gland: gene expression and effects of CER and [des-Ser1]CER on the secretion and growth of cultured adrenocortical cells. (PMID: 15702230) Rucinski M. … Malendowicz L.K. (Int. J. Mol. Med. 2005) 23 67
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 67
  4. Adrenocortical peptides: autocrine or paracrine regulators for the steroid hormone secretion or the cell proliferation? (PMID: 12518246) Takahashi K. … Murakami O. (Exp. Clin. Endocrinol. Diabetes 2002) 23 67
  5. Cerebellin stimulates the secretory activity of the rat adrenal gland: in vitro and in vivo studies. (PMID: 10688962) Albertin G. … Nussdorfer G.G. (Neuropeptides 2000) 23 67

Products for CBLN3 Gene

Sources for CBLN3 Gene

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