Aliases for CBLN3 Gene
External Ids for CBLN3 Gene
- HGNC: 20146
- Entrez Gene: 643866
- Ensembl: ENSG00000139899
- OMIM: 612978
- UniProtKB: Q6UW01
Previous GeneCards Identifiers for CBLN3 Gene
- GC00U907483
- GC14U900191
- GC14M023967
- GC14M024895
- GC14M005010
Summaries for CBLN3 Gene
-
Members of the precerebellin family, such as CBLN3, contain a cerebellin motif (see CBLN1; MIM 600432) and a C-terminal C1q signature domain (see MIM 120550) that mediates trimeric assembly of atypical collagen complexes. However, precerebellins do not contain a collagen motif, suggesting that they are not conventional components of the extracellular matrix (Pang et al., 2000 [PubMed 10964938]).[supplied by OMIM, Aug 2009]
GeneCards Summary for CBLN3 Gene
CBLN3 (Cerebellin 3 Precursor) is a Protein Coding gene. An important paralog of this gene is CBLN2.
UniProtKB/Swiss-Prot for CBLN3 Gene
-
May be involved in synaptic functions in the CNS.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBLN3 Gene
Genomics for CBLN3 Gene
Regulatory Elements for CBLN3 Gene
Enhancers for CBLN3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CBLN3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CBLN3 gene promoter:
Regulatory Element Products
Genomic Location for CBLN3 Gene
- Chromosome:
- 14
- Start:
- 24,426,532 bp from pter
- End:
- 24,430,954 bp from pter
- Size:
- 4,423 bases
- Orientation:
- Minus strand
Genomic View for CBLN3 Gene
Genes around CBLN3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q12 by Ensembl
- 14q12 by Entrez Gene
- 14q12 by HGNC
CBLN3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBLN3 Gene
Proteins for CBLN3 Gene
-
Protein details for CBLN3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UW01-CBLN3_HUMAN
- Recommended name:
- Cerebellin-3
- Protein Accession:
- Q6UW01
Protein attributes for CBLN3 Gene
- Size:
- 205 amino acids
- Molecular mass:
- 21521 Da
- Quaternary structure:
-
- Heterohexamer; disulfide-linked heterotrimers. Interacts with CBLN1. May also form oligomers with CBLN2 AND CBLN4 (By similarity).
Post-translational modifications for CBLN3 Gene
Other Protein References for CBLN3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CBLN3
- Invitrogen Antibodies for CBLN3
- antibodies-online Antibodies for CBLN3: See all 15
- GeneTex CBLN3 antibody for CBLN3
Protein Products
-
OriGene Purified Proteins for CBLN3
- Search Origene for MassSpec and Protein Over-expression Lysates for CBLN3
- Origene Custom Protein Services for CBLN3
- antibodies-online Proteins for CBLN3: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CBLN3
Assay Products
- antibodies-online Kits for CBLN3: See all 4
No data available for DME Specific Peptides for CBLN3 Gene
Domains & Families for CBLN3 Gene
Protein Domains for CBLN3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CBLN3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for CBLN3 Gene
Function for CBLN3 Gene
Molecular function for CBLN3 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in synaptic functions in the CNS.
Phenotypes for CBLN3 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CBLN3
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBLN3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CBLN3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBLN3 gene
- Search ViGene Biosciences for CBLN3
CRISPR Products
-
OriGene CRISPR knockouts for CBLN3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBLN3
- GenScript: Design CRISPR guide RNA sequences for CBLN3
miRNA for CBLN3 Gene
- miRTarBase miRNAs that target CBLN3
-
- mmu-mir-297a-5p (MIRT013149)
- mmu-mir-342-3p (MIRT577143)
- mmu-mir-377-3p (MIRT577144)
- mmu-mir-1955-5p (MIRT584456)
- mmu-mir-3090-3p (MIRT584457)
- mmu-mir-362-3p (MIRT584458)
- mmu-mir-329-3p (MIRT584460)
- mmu-mir-3082-5p (MIRT592801)
- mmu-mir-706 (MIRT592802)
- mmu-mir-10b-5p (MIRT592803)
- mmu-mir-10a-5p (MIRT592804)
- mmu-mir-339-5p (MIRT592805)
- mmu-mir-292a-5p (MIRT592806)
- mmu-mir-290a-5p (MIRT592807)
- mmu-mir-1946a (MIRT601083)
- mmu-mir-3102-5p (MIRT601084)
- mmu-mir-546 (MIRT601085)
- mmu-mir-1935 (MIRT601086)
- mmu-mir-298-5p (MIRT601087)
- mmu-mir-876-5p (MIRT601088)
- mmu-mir-1199-5p (MIRT601089)
- mmu-mir-3089-5p (MIRT601090)
- mmu-mir-1195 (MIRT601091)
- mmu-mir-5135 (MIRT601092)
- mmu-mir-709 (MIRT602650)
miRNA Products
- Search ViGene Biosciences for CBLN3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBLN3
- Browse OriGene Inhibitory RNA Products For CBLN3
-
ViGene Biosciences ready-to-package AAV shRNAs for CBLN3 gene
Clone Products
-
OriGene ORF clones in human for CBLN3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CBLN3
- VectorBuilder custom plasmid, inducible vectors for CBLN3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBLN3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CBLN3
-
ViGene Biosciences adenoviral particle packaged cDNA for CBLN3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CBLN3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBLN3 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBLN3 Gene
Localization for CBLN3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CBLN3 Gene
- Endoplasmic reticulum. Golgi apparatus, cis-Golgi network. Secreted. Cell junction, synapse. Note=In the absence of CBLN1, remains in the endoplasmic reticulum/cis-Golgi apparatus. Partial secretion depends on a association with CBLN1 and maybe CBLN4, but not on CBLN2 (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| endoplasmic reticulum | 4 |
| golgi apparatus | 3 |
| nucleus | 2 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0030054 | cell junction | IEA | -- |
| GO:0045202 | synapse | IEA | -- |
Pathways & Interactions for CBLN3 Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for CBLN3 Gene
Transcripts for CBLN3 Gene
mRNA/cDNA for CBLN3 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CBLN3 Gene
- Cerebellin 3 precursor:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CBLN3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBLN3
- GenScript: Design CRISPR guide RNA sequences for CBLN3
miRNA Products
- Search ViGene Biosciences for CBLN3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBLN3
- Browse OriGene Inhibitory RNA Products For CBLN3
-
ViGene Biosciences ready-to-package AAV shRNAs for CBLN3 gene
Clone Products
-
OriGene ORF clones in human for CBLN3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CBLN3
- VectorBuilder custom plasmid, inducible vectors for CBLN3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBLN3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CBLN3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
mRNA differential expression in normal tissues according to GTEx for CBLN3 Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x21.5) and Brain - Cerebellum (x19.5).
NURSA nuclear receptor signaling pathways regulating expression of CBLN3 Gene:
CBLN3SOURCE GeneReport for Unigene cluster for CBLN3 Gene:
Hs.207603Primer Products
-
OriGene qPCR primer pairs for CBLN3
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBLN3 Gene
Orthologs for CBLN3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CBLN3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CBLN3 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cbln3 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CBLN3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Cbln3 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CBLN3 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | BX664707.1 35 |
|
ManyToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for CBLN3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CBLN3 Gene
Variants for CBLN3 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000300505 | -- | 24,428,239(+) | TTCCC(C/T)CTCCC | intron-variant, upstream-variant-2KB | |
| rs1000564660 | -- | 24,426,607(+) | ACACC(C/T)GATCC | intron-variant, utr-variant-3-prime | |
| rs1003624867 | -- | 24,428,412(+) | TGGGG(A/G)AAGCA | intron-variant, upstream-variant-2KB | |
| rs1003740892 | -- | 24,428,729(+) | CAGGT(C/T)CCCTG | intron-variant, upstream-variant-2KB | |
| rs1004295122 | -- | 24,427,355(+) | CACAG(A/G)AAGAA | intron-variant, upstream-variant-2KB, utr-variant-3-prime |
Residual Variation Intolerance Score:
62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.32;
7.06% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CBLN3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CBLN3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CBLN3 Gene
Disorders for CBLN3 Gene
Relevant External Links for CBLN3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CBLN3
No disorders were found for CBLN3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBLN3 Gene
Publications for CBLN3 Gene
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
- Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 64
- Functional roles of neuropeptides in cerebellar circuits. (PMID: 19361475) Ito M. (Neuroscience 2009) 22 64
- Cbln1 is essential for interaction-dependent secretion of Cbln3. (PMID: 17030622) Bao D. … Morgan J.I. (Mol. Cell. Biol. 2006) 3 64
Products for CBLN3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CBLN3
- Search Origene for MassSpec and Protein Over-expression Lysates for CBLN3
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBLN3
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- OriGene qPCR primer pairs for CBLN3
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- GenScript: Next-day shipping cDNA ORF clone for CBLN3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CBLN3
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- GenScript: Design CRISPR guide RNA sequences for CBLN3
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for CBLN3
- Novus Biologicals proteins and lysates for CBLN3
- Novus Biologicals
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- Taconic Biosciences Mouse Models for CBLN3
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- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CBLN3
- antibodies-online Antibodies for CBLN3: See all 15
- antibodies-online Kits for CBLN3: See all 4
- antibodies-online Proteins for CBLN3: See all 5
- Search antibodies-online for peptides
- GeneTex CBLN3 antibody for CBLN3
- Search GeneTex for Proteins for CBLN3
- ViGene Biosciences adenoviral particle packaged cDNA for CBLN3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CBLN3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CBLN3 gene
- Search ViGene Biosciences for CBLN3
- Horizon Cell Lines for CBLN3
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBLN3
- VectorBuilder custom plasmid, inducible vectors for CBLN3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBLN3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CBLN3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer