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Aliases for CBLN2 Gene

Aliases for CBLN2 Gene

  • Cerebellin 2 Precursor 2 3 5

External Ids for CBLN2 Gene

Previous GeneCards Identifiers for CBLN2 Gene

  • GC18U990007
  • GC18M068352
  • GC18M068354
  • GC18M070203
  • GC18M066922

Summaries for CBLN2 Gene

GeneCards Summary for CBLN2 Gene

CBLN2 (Cerebellin 2 Precursor) is a Protein Coding gene. An important paralog of this gene is C1QL4.

UniProtKB/Swiss-Prot for CBLN2 Gene

  • May play role in synaptogenesis induction.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBLN2 Gene

Genomics for CBLN2 Gene

Regulatory Elements for CBLN2 Gene

Enhancers for CBLN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CBLN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CBLN2 Gene

Chromosome:
18
Start:
72,535,898 bp from pter
End:
72,638,521 bp from pter
Size:
102,624 bases
Orientation:
Minus strand

Genomic View for CBLN2 Gene

Genes around CBLN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBLN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBLN2 Gene

Proteins for CBLN2 Gene

  • Protein details for CBLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUK8-CBLN2_HUMAN
    Recommended name:
    Cerebellin-2
    Protein Accession:
    Q8IUK8
    Secondary Accessions:
    • Q53Z56

    Protein attributes for CBLN2 Gene

    Size:
    224 amino acids
    Molecular mass:
    24084 Da
    Quaternary structure:
    • May form homooligomers or heterooligomers with CBLN1 and CBLN3 prior to secretion. Once secreted, does not interact with other CBLN family members. Interacts with GRID2, and more weakly with GRID1. Interacts with NRXN1 and NRXN2 long and short isoforms produced by alternative promoter usage. Weakly interacts with NRXN3 short isoform and not at all with NRXN3 long isoform (By similarity).

neXtProt entry for CBLN2 Gene

Proteomics data for CBLN2 Gene at MOPED

Post-translational modifications for CBLN2 Gene

  • Glycosylation at Asn 53 and Asn 110
  • Modification sites at PhosphoSitePlus

Other Protein References for CBLN2 Gene

No data available for DME Specific Peptides for CBLN2 Gene

Domains & Families for CBLN2 Gene

Protein Domains for CBLN2 Gene

Suggested Antigen Peptide Sequences for CBLN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUK8

UniProtKB/Swiss-Prot:

CBLN2_HUMAN :
  • Contains 1 C1q domain.
Domain:
  • Contains 1 C1q domain.
genes like me logo Genes that share domains with CBLN2: view

No data available for Gene Families for CBLN2 Gene

Function for CBLN2 Gene

Molecular function for CBLN2 Gene

UniProtKB/Swiss-Prot Function:
May play role in synaptogenesis induction.
genes like me logo Genes that share phenotypes with CBLN2: view

Animal Models for CBLN2 Gene

MGI Knock Outs for CBLN2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CBLN2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBLN2 Gene

Localization for CBLN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBLN2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBLN2 Gene COMPARTMENTS Subcellular localization image for CBLN2 gene
Compartment Confidence
extracellular 4
plasma membrane 2
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CBLN2 Gene

Pathways & Interactions for CBLN2 Gene

SuperPathways for CBLN2 Gene

No Data Available

Interacting Proteins for CBLN2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000269503%0d%0a9606.ENSP00000267406%0d%0a
Selected Interacting proteins: ENSP00000269503 Q8IUK8-CBLN2_HUMAN for CBLN2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CBLN2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CBLN2 Gene

Drugs & Compounds for CBLN2 Gene

No Compound Related Data Available

Transcripts for CBLN2 Gene

Unigene Clusters for CBLN2 Gene

Cerebellin 2 precursor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CBLN2 Gene

No ASD Table

Relevant External Links for CBLN2 Gene

GeneLoc Exon Structure for
CBLN2
ECgene alternative splicing isoforms for
CBLN2

Expression for CBLN2 Gene

mRNA expression in normal human tissues for CBLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CBLN2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x14.3), Brain - Cortex (x13.0), and Brain - Anterior cingulate cortex (BA24) (x11.4).

Protein differential expression in normal tissues from HIPED for CBLN2 Gene

This gene is overexpressed in Pancreatic juice (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CBLN2 Gene



SOURCE GeneReport for Unigene cluster for CBLN2 Gene Hs.569851

genes like me logo Genes that share expression patterns with CBLN2: view

Protein tissue co-expression partners for CBLN2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CBLN2 Gene

Orthologs for CBLN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CBLN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CBLN2 35
  • 91.07 (n)
  • 95.98 (a)
CBLN2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CBLN2 35
  • 89.14 (n)
  • 90.99 (a)
CBLN2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cbln2 35
  • 89.58 (n)
  • 94.2 (a)
Cbln2 16
Cbln2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CBLN2 35
  • 100 (n)
  • 100 (a)
CBLN2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cbln2 35
  • 88.99 (n)
  • 94.64 (a)
oppossum
(Monodelphis domestica)
Mammalia CBLN2 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CBLN2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves CBLN2 35
  • 88.89 (n)
  • 95.65 (a)
CBLN2 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CBLN2 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cbln2 35
  • 80.49 (n)
  • 92.05 (a)
African clawed frog
(Xenopus laevis)
Amphibia cbln2-prov 35
zebrafish
(Danio rerio)
Actinopterygii cbln2a 36
  • 77 (a)
OneToMany
cbln2b 36
  • 81 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for CBLN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBLN2 Gene

ENSEMBL:
Gene Tree for CBLN2 (if available)
TreeFam:
Gene Tree for CBLN2 (if available)

Paralogs for CBLN2 Gene

(5) SIMAP similar genes for CBLN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CBLN2: view

Variants for CBLN2 Gene

Sequence variations from dbSNP and Humsavar for CBLN2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs88406 -- 72,610,733(-) AGCCA(C/T)TTGAT intron-variant
rs1560559 -- 72,629,187(-) AAATG(A/G)ATTTC intron-variant
rs1594561 -- 72,593,118(-) TATTC(A/G)TGAAT intron-variant
rs7230930 -- 72,621,947(+) aagat(C/G)gagtg intron-variant
rs7232530 -- 72,548,180(+) ACTAA(A/G)CTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CBLN2 Gene

Variant ID Type Subtype PubMed ID
nsv833693 CNV Gain 17160897

Variation tolerance for CBLN2 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CBLN2 Gene

Disorders for CBLN2 Gene

Relevant External Links for CBLN2

Genetic Association Database (GAD)
CBLN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBLN2

No disorders were found for CBLN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBLN2 Gene

Publications for CBLN2 Gene

  1. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PMID: 19010793) Baranzini S.E. … Oksenberg J.R. (Hum. Mol. Genet. 2009) 3 48 67
  2. Genomic structure and mapping of precerebellin and a precerebellin-related gene. (PMID: 7877445) Kavety B. … Morgan J.I. (Brain Res. Mol. Brain Res. 1994) 2 3
  3. Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension. (PMID: 23502781) Germain M. … Soubrier F. (Nat. Genet. 2013) 3
  4. Comparison of Cbln1 and Cbln2 functions using transgenic and knockout mice. (PMID: 22117778) Rong Y. … Morgan J.I. (J. Neurochem. 2012) 3
  5. Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFI+ inhibitors in patients with rheumatoid arthritis. (PMID: 22569225) Krintel S.B. … Hetland M.L. (Pharmacogenet. Genomics 2012) 3

Products for CBLN2 Gene

Sources for CBLN2 Gene

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