Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CBLN2 Gene

protein-coding   GIFtS: 50
GCID: GC18M070203

Cerebellin 2 Precursor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cerebellin 2 Precursor1 2
cerebellin-22

External Ids:    HGNC: 15441   Entrez Gene: 1473812   Ensembl: ENSG000001416687   OMIM: 6004335   UniProtKB: Q8IUK83   
ORGUL members:         

Export aliases for CBLN2 gene to outside databases

Previous GC identifers: GC18U990007 GC18M068352 GC18M068354 GC18M066922


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for CBLN2 Gene:
CBLN2 (cerebellin 2 precursor) is a protein-coding gene. Diseases associated with CBLN2 include primary pulmonary hypertension, and heritable pulmonary arterial hypertension. An important paralog of this gene is C1QL3.

UniProtKB/Swiss-Prot: CBLN2_HUMAN, Q8IUK8
Function: May play role in synaptogenesis induction (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000018.10  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CBLN2 gene promoter:
         TBP   NF-1   USF1   FOXF2   Nkx2-5   FOXL1   Gfi-1   MEF-2A   USF-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCBLN2 promoter sequence
   Search Chromatin IP Primers for CBLN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CBLN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.3   Ensembl cytogenetic band:  18q22.3   HGNC cytogenetic band: 18q22.3

CBLN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBLN2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M070203:  view genomic region     (about GC identifiers)

Start:
70,203,915 bp from pter      End:
70,305,756 bp from pter
Size:
101,842 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CBLN2_HUMAN, Q8IUK8 (See protein sequence)
Recommended Name: Cerebellin-2 precursor  
Size: 224 amino acids; 24084 Da
Subunit: May form homooligomers or heterooligomers with CBLN1 and CBLN3 prior to secretion. Once secreted, does
not interact with other CBLN family members. Interacts with GRID2, and more weakly with GRID1. Interacts with
NRXN1 and NRXN2 long and short isoforms produced by alternative promoter usage. Weakly interacts with NRXN3 short
isoform and not at all with NRXN3 long isoform (By similarity)
Secondary accessions: Q53Z56

Explore the universe of human proteins at neXtProt for CBLN2: NX_Q8IUK8

Explore proteomics data for CBLN2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn53, Asn110

  • See CBLN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_872317.1  
    ENSEMBL proteins: 
     ENSP00000463771   ENSP00000269503   ENSP00000464490   ENSP00000462632  

    CBLN2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CBLN2 (Cerebellin-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CBLN2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CBLN2
    GenScript Custom Purified and Recombinant Proteins Services for CBLN2
    Novus Biologicals CBLN2 Protein
    Novus Biologicals CBLN2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CBLN2

    CBLN2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CBLN2 (Cerebellin-2)
    OriGene Antibodies for CBLN2
    OriGene Custom Antibody Services for CBLN2
    Novus Biologicals CBLN2 Antibody
    Abcam antibodies for CBLN2
    Cloud-Clone Corp. Antibodies for CBLN2
    Search ThermoFisher Antibodies for CBLN2
    LSBio Antibodies in human, mouse, rat for CBLN2

    CBLN2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CBLN2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CBLN2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CBLN2
    Cloud-Clone Corp. CLIAs for CBLN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR008983 Tumour_necrosis_fac-like_dom
     IPR001073 C1q

    Graphical View of Domain Structure for InterPro Entry Q8IUK8

    ProtoNet protein and cluster: Q8IUK8

    1 Blocks protein domain: IPB001073 Complement C1q protein

    UniProtKB/Swiss-Prot: CBLN2_HUMAN, Q8IUK8
    Similarity: Contains 1 C1q domain


    CBLN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBLN2_HUMAN, Q8IUK8
    Function: May play role in synaptogenesis induction (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CBLN2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cbln2):
     behavior/neurological  nervous system 

    CBLN2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cbln2tm1Jim for CBLN2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CBLN2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CBLN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CBLN2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CBLN2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CBLN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CBLN2 (see all 11):
    hsa-miR-517a hsa-miR-526b hsa-miR-513a-5p hsa-miR-517c hsa-miR-548e hsa-miR-517b hsa-miR-1284 hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmidCBLN2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CBLN2
    Predesigned siRNA for gene silencing in human, mouse, rat CBLN2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CBLN2

    Clone
    Products:
         
    OriGene clones in human, mouse for CBLN2 (see all 6)
    OriGene ORF clones in mouse, rat for CBLN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CBLN2 (NM_182511)
    Sino Biological Human cDNA Clone for CBLN2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBLN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBLN2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CBLN2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CBLN2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLN2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CBLN2_HUMAN, Q8IUK8: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    plasma membrane2
    endosome1
    lysosome1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    CBLN2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CBLN2
    Interactions:

        Search GeneGlobe Interaction Network for CBLN2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CBLN2 (Q8IUK83 ENSP000002695034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLN3Q6UW013, ENSP000002674064I2D: score=1 STRING: ENSP00000267406
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051965positive regulation of synapse assembly IEA--

    CBLN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CBLN2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CBLN2 gene: 
    NM_182511.3  

    Unigene Cluster for CBLN2:

    Cerebellin 2 precursor
    Hs.569851  [show with all ESTs]
    Unigene Representative Sequence: AK125422
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585159(uc002lku.2) ENST00000269503(uc002lkv.2) ENST00000581425
    ENST00000584764 ENST00000583651 ENST00000581073 ENST00000580889 ENST00000583570
    ENST00000582667
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CBLN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CBLN2 (see all 11):
    hsa-miR-517a hsa-miR-526b hsa-miR-513a-5p hsa-miR-517c hsa-miR-548e hsa-miR-517b hsa-miR-1284 hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmidCBLN2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CBLN2
    Predesigned siRNA for gene silencing in human, mouse, rat CBLN2
    Clone
    Products:
         
    OriGene clones in human, mouse for CBLN2 (see all 6)
    OriGene ORF clones in mouse, rat for CBLN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CBLN2 (NM_182511)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBLN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBLN2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CBLN2
    OriGene qSTAR qPCR primer pairs in human, mouse for CBLN2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBLN2
      QuantiTect SYBR Green Assays in human, mouse, rat CBLN2
      QuantiFast Probe-based Assays in human, mouse, rat CBLN2

    Additional mRNA sequence: 

    AK125422.1 AK291364.1 AY359074.1 BC035789.1 BC110843.1 

    3 DOTS entries:

    DT.75130678  DT.97783826  DT.100684052 

    Selected AceView cDNA sequences (see all 29):

    AW162063 BU734103 NM_182511 CB118124 AY359074 BX409762 T17432 BI917364 
    BC035789 AK125422 BX409761 AA332557 BM723762 AA340432 BM987080 BU102038 
    BX460500 R36770 CA396230 BE644911 AW163243 BI871154 AW965432 AI815729 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CBLN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCTGGCGA
    CBLN2 Expression
    About this image


    CBLN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Mature Endothelial Cells Blood Brain Barrier
             Thalamus
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 7
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
    CBLN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CBLN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.569851
        Custom PCR Arrays for CBLN2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CBLN2
    OriGene qSTAR qPCR primer pairs in human, mouse for CBLN2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBLN2
    QuantiTect SYBR Green Assays in human, mouse, rat CBLN2
    QuantiFast Probe-based Assays in human, mouse, rat CBLN2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CBLN2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cbln21 , 5 cerebellin 2 precursor protein1, 5 89.58(n)1
    94.2(a)1
      18 (58.63 cM)5
    124051  NM_172633.31  NP_766221.11 
     867111105 
    chicken
    (Gallus gallus)
    Aves CBLN21 cerebellin 2 88.89(n)
    95.65(a)
      421019  NM_001171768.1  NP_001165239.1 
    lizard
    (Anolis carolinensis)
    Reptilia CBLN26
    cerebellin 2 precursor
    91(a)
    1 ↔ 1
    4(48247810-48258312)
    African clawed frog
    (Xenopus laevis)
    Amphibia cbln2-prov2 cerebellin 2 precursor protein 80.96(n)    BC054217.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cbln2b6
    cbln2a6
    cerebellin 2a precursor
    81(a)
    77(a)
    1 ↔ many
    1 ↔ many
    24(15549597-15552769) ENSDARG00000077151
    2(30173538-30175125) ENSDARG00000074601


    ENSEMBL Gene Tree for CBLN2 (if available)
    TreeFam Gene Tree for CBLN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CBLN2 gene
    C1QL32  CBLN12  C1QTNF32  CAPRIN12  ENSG000002732942  C1QL22  CBLN32  CAPRIN22  
    C1QL12  CBLN42  C1QL42  
    5 SIMAP similar genes for CBLN2 using alignment to 3 protein entries:     CBLN2_HUMAN (see all proteins):
    CBLN4    CBLN1    CBLN3    CAPRIN2    COL8A2

    CBLN2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CBLN2 (see all 222)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs759810511,2
    C--70203419(+) CAGTAA/TAACTT 1 -- int10--------
    rs773012531,2
    C--70203421(+) GTAAAA/CCTTAG 1 -- int10--------
    rs761930871,2
    --70203485(+) TCTTCA/GAAAAT 1 -- int10--------
    rs1180227421,2
    C,F--70203543(+) TTATGC/TGCTTA 1 -- int11Minor allele frequency- T:0.02NA 120
    rs1909967441,2
    --70203544(+) TATGCA/GCTTAA 1 -- int10--------
    rs1439616541,2
    --70203648(+) CCTAGA/CCCTAA 1 -- int10--------
    rs1505369121,2
    --70203776(+) GTCTGC/TACATA 1 -- int10--------
    rs6166821,2
    C,F,A,H--70203793(+) TGTGTG/ATGTTT 1 -- int123Minor allele frequency- A:0.20NS EA NA WA CSA 1781
    rs2020426301,2
    --70203796(+) GTATG-/TTTGAGA 1 -- int10--------
    rs1403910811,2
    C--70203797(+) TATGT-/TTGA  
            
    GAGTA
    1 -- int10--------

    HapMap Linkage Disequilibrium report for CBLN2 (70203915 - 70305756 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CBLN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833693CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CBLN2
    DNA2.0 Custom Variant and Variant Library Synthesis for CBLN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600433    OMIM disorders: --

    9 diseases for CBLN2:    
    About MalaCards
    primary pulmonary hypertension    heritable pulmonary arterial hypertension    gilles de la tourette syndrome    rheumatoid arthritis
    arthritis    multiple sclerosis    hypertension    cerebritis
    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for CBLN2:
    Gilles de la Tourette syndrome

    CBLN2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CBLN2

    Export disorders for CBLN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CBLN2 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with CBLN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PubMed id 19010793)1, 4 Baranzini S.E....Oksenberg J.R. (Hum. Mol. Genet. 2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Genomic structure and mapping of precerebellin and a precerebellin-related gene. (PubMed id 7877445)1, 3 Kavety B....Morgan J.I. (Brain Res. Mol. Brain Res. 1994)
    6. Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension. (PubMed id 23502781)1 Germain M....Soubrier F. (Nat. Genet. 2013)
    7. Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFI+ inhibitors in patients with rheumatoid arthritis. (PubMed id 22569225)1 Krintel S.B....Hetland M.L. (Pharmacogenet. Genomics 2012)
    8. Comparison of Cbln1 and Cbln2 functions using transgenic and knockout mice. (PubMed id 22117778)1 Rong Y....Morgan J.I. (J. Neurochem. 2012)
    9. Cbln1 is essential for interaction-dependent secretion of Cbln3. (PubMed id 17030622)1 Bao D....Morgan J.I. (Mol. Cell. Biol. 2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 147381 HGNC: 1544 AceView: CBLN2 Ensembl:ENSG00000141668 euGenes: HUgn147381
    ECgene: CBLN2 H-InvDB: CBLN2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CBLN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CBLN2 gene:
    Search GeneIP for patents involving CBLN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for CBLN2 (Cerebellin-2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for CBLN2 (Cerebellin-2)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CBLN2   OriGene RNAi products in human, mouse, rat for CBLN2  
     OriGene qPCR primer pairs and template standards for CBLN2   OriGene Protein Over-expression Lysate for CBLN2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CBLN2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CBLN2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CBLN2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CBLN2   OriGene Custom Protein Services for CBLN2  

     
     
     Block miRNA regulation of human, mouse, rat CBLN2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CBLN2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CBLN2 Predesigned siRNA for gene silencing in human, mouse, rat CBLN2
     QuantiFast Probe-based Assays in human, mouse, rat CBLN2 QuantiTect SYBR Green Assays in human, mouse, rat CBLN2
     Custom PCR Arrays for CBLN2 Search Chromatin IP Primers for CBLN2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBLN2  Search GeneGlobe Interaction Network for CBLN2
     Regulatory tfbs in CBLN2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CBLN2 GenScript cDNA clones with any tag delivered in your preferred vector for CBLN2
     GenScript Custom Assay Services for CBLN2 GenScript Custom overexpressing Cell Line Services for CBLN2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CBLN2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CBLN2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CBLN2 antibodies
     CBLN2 proteins
     CBLN2 lysates
     Antibodies for CBLN2
     See all of Abcam's Antibodies, Kits and Proteins for CBLN2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CBLN2
     Antibodies for CBLN2
     ELISAs for CBLN2
     CLIAs for CBLN2



     Browse ESI BIO Cell Lines and PureStem Progenitors for CBLN2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLN2
     SwitchGear 3'UTR luciferase reporter plasmids for CBLN2
     SwitchGear Promoter luciferase reporter plasmids for CBLN2
     Search ThermoFisher Antibodies for CBLN2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBLN2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CBLN2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CBLN2
     LSBio Antibodies in human, mouse, rat for CBLN2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CBLN2 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4