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CBLN1 Gene

protein-coding   GIFtS: 54
GCID: GC16M049359

Cerebellin 1 Precursor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cerebellin 1 Precursor1 2
cerebellin-12
precerebellin2
Precerebellin3
CLN15

External Ids:    HGNC: 15431   Entrez Gene: 8692   Ensembl: ENSG000001029247   OMIM: 6004325   UniProtKB: P234353   

Export aliases for CBLN1 gene to outside databases

Previous GC identifers: GC16M039726 GC16M049049 GC16M049090 GC16M047870 GC16M035201


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CBLN1 Gene:
This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular
(non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several
derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of
Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the
secretory activity of this gland. (provided by RefSeq, Aug 2008)

GeneCards Summary for CBLN1 Gene:
CBLN1 (cerebellin 1 precursor) is a protein-coding gene. Diseases associated with CBLN1 include benign paroxysmal positional nystagmus, and osteoporosis. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is CBLN2.

UniProtKB/Swiss-Prot: CBLN1_HUMAN, P23435
Function: Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential
for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact
with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to
the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further
accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell
functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic
reticulum and secretion (By similarity)
Function: The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via
the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo,
through a paracrine mechanism involving medullary catecholamine release (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CBLN1 gene promoter:
         MEF-2   NRSF form 1   Nkx2-5   NRSF form 2   HEN1   MEF-2A   CREB   Pax-3   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCBLN1 promoter sequence
   Search Chromatin IP Primers for CBLN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CBLN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.1   Ensembl cytogenetic band:  16q12.1   HGNC cytogenetic band: 16q12.1

CBLN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBLN1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M049359:  view genomic region     (about GC identifiers)

Start:
49,311,828 bp from pter      End:
49,315,742 bp from pter
Size:
3,915 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CBLN1_HUMAN, P23435 (See protein sequence)
Recommended Name: Cerebellin-1 precursor  
Size: 193 amino acids; 21097 Da
Subunit: Homohexamer; disulfide-linked homotrimers. The trimers are assembled via the globular C1q domains. The
trimers associate via N-terminal cysteine residues to form disulfide-linked hexamers. May form oligomers with
CBLN2, CBLN3 AND CBLN4 prior to secretion. Once secreted, does not interact with other CBLN family members.
Interacts with GRID1 and GRID2. GRID2-binding is calcium-independent. Interacts with NRXN1 and NRXN2 long (alpha)
and short (beta) isoforms produced by alternative promoter usage. Competes with NLGN1 for NRXN1-binding. Weakly
interacts with NRXN3 short isoform and not at all with NRXN3 long isoform (By similarity)
Developmental stage: Low at birth, the cerebellin concentration increases between day 5 and 15, and reaches peak
values between day 21 and 56
Secondary accessions: B2RAN9 P02682 Q52M09

Explore the universe of human proteins at neXtProt for CBLN1: NX_P23435

Explore proteomics data for CBLN1 at MOPED

Post-translational modifications: 

  • The proteolytic processing to yield cerebellin seems to occur either prior to the secretion by presynaptic neurons
    and subsequent oligomerization or in some other location after release of the mature protein1
  • Glycosylation2 at Asn23, Asn79

  • See CBLN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004343.1  
    ENSEMBL proteins: 
     ENSP00000219197   ENSP00000455718   ENSP00000444651  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR008983 Tumour_necrosis_fac-like_dom
     IPR001073 C1q

    Graphical View of Domain Structure for InterPro Entry P23435

    ProtoNet protein and cluster: P23435

    1 Blocks protein domain: IPB001073 Complement C1q protein

    UniProtKB/Swiss-Prot: CBLN1_HUMAN, P23435
    Similarity: Contains 1 C1q domain


    CBLN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBLN1_HUMAN, P23435
    Function: Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential
    for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact
    with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to
    the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further
    accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell
    functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic
    reticulum and secretion (By similarity)
    Function: The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via
    the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo,
    through a paracrine mechanism involving medullary catecholamine release (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity IEA--
         
    CBLN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CBLN1:
     Increased circadian period len 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cbln1):
     behavior/neurological  nervous system  normal 

    CBLN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cbln1tm1Jim for CBLN1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CBLN1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CBLN1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CBLN1

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CBLN1 (see all 17):
    hsa-miR-320a hsa-miR-3653 hsa-miR-3658 hsa-miR-23a hsa-miR-376c hsa-miR-3690 hsa-miR-548p hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidCBLN1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CBLN1

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CBLN1_HUMAN, P23435: Secreted. Cell junction, synapse, postsynaptic cell membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    endosome1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0030054cell junction IEA--
    GO:0045202synapse ----
    GO:0045211postsynaptic membrane IEA--

    CBLN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including CBLN1: 
              Neurotrophins & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CBLN1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for CBLN1 (P234353 ENSP000002191974) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLN3Q6UW013, ENSP000002674064I2D: score=1 STRING: ENSP00000267406
    GRID2O434243I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007157heterophilic cell-cell adhesion ISS--
    GO:0007268synaptic transmission TAS1704129
    GO:0007399nervous system development TAS1704129
    GO:0009306protein secretion IEA--
    GO:0021707cerebellar granule cell differentiation ISS--

    CBLN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CBLN1

    2 Novoseek inferred chemical compound relationships for CBLN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 33.1 1 10688962 (1)
    norepinephrine 20.5 1 10688962 (1)



    CBLN1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CBLN1 gene: 
    NM_004352.3  

    Unigene Cluster for CBLN1:

    Cerebellin 1 precursor
    Hs.458423  [show with all ESTs]
    Unigene Representative Sequence: NM_004352
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000219197(uc002efq.3) ENST00000564786 ENST00000536749
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CBLN1 (see all 17):
    hsa-miR-320a hsa-miR-3653 hsa-miR-3658 hsa-miR-23a hsa-miR-376c hsa-miR-3690 hsa-miR-548p hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidCBLN1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CBLN1
      QuantiFast Probe-based Assays in human, mouse, rat CBLN1

    Additional mRNA sequence: 

    AK314276.1 BC093692.1 BC093718.1 M58583.1 

    3 DOTS entries:

    DT.455159  DT.100702469  DT.120659494 

    Selected AceView cDNA sequences (see all 34):

    T16851 T30957 AI092751 M58583 AA324367 AA425008 AW950296 AA495901 
    BM563942 AI337927 AA351724 AI130730 BX096195 BX394263 AA351125 AW086497 
    AI147523 BX348700 AA758163 NM_004352 BE779117 AA323626 AI028715 BG709519 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CBLN1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for CBLN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CBLN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CBLN1 Expression
    About this image


    CBLN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Thalamus
             Midbrain dopaminergic-like neurons
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
             Midbrain dopaminergic-like neurons
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Testicular Interstitial Cells Testis Interstitium
             Seminiferous Tubules
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
    CBLN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CBLN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458423

    UniProtKB/Swiss-Prot: CBLN1_HUMAN, P23435
    Tissue specificity: In the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less
    abundant than [des-Ser1]-cerebellin

        Pathway & Disease-focused RT2 Profiler PCR Array including CBLN1: 
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CBLN1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cbln11 , 5 cerebellin 1 precursor protein1, 5 94.3(n)1
    98.96(a)1
      8 (42.16 cM)5
    124041  NM_019626.31  NP_062600.21 
     874688545 
    chicken
    (Gallus gallus)
    Aves CBLN11 cerebellin 1 precursor 80.36(n)
    88.69(a)
      771265  XM_004944186.1  XP_004944243.1 
    lizard
    (Anolis carolinensis)
    Reptilia CBLN16
    cerebellin 1 precursor
    95(a)
    1 ↔ 1
    GL343469.1(205738-222186)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cbln11 cerebellin 1 precursor 79.96(n)
    94.22(a)
      779761  NM_001078840.1  NP_001072308.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.125342 Transcribed sequence with moderate similarity to protein more 77.04(n)    BI533676.1 


    ENSEMBL Gene Tree for CBLN1 (if available)
    TreeFam Gene Tree for CBLN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CBLN1 gene
    CBLN22  C1QL32  C1QTNF32  CAPRIN12  ENSG000002732942  C1QL22  CBLN32  CAPRIN22  
    C1QL12  CBLN42  C1QL42  
    5 SIMAP similar genes for CBLN1 using alignment to 2 protein entries:     CBLN1_HUMAN (see all proteins):
    CBLN4    CBLN2    CBLN3    CAPRIN2    C1QL1

    CBLN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CBLN1 (see all 140)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs564028671,2
    --49311350(+) TCTCAC/TTCACA 1 -- ds50010--------
    rs1904834091,2
    --49311389(+) GAAACA/TGTTGG 1 -- ds50010--------
    rs1166120541,2
    C,F--49311458(+) GTGGGT/CCCCGG 1 -- ds50011Minor allele frequency- C:0.09WA 118
    rs775409931,2
    C,F--49311469(+) AGGCAC/TAGGGC 1 -- ds50011Minor allele frequency- T:0.09WA 118
    rs1817584151,2
    --49311484(+) AGGGCA/GCCCGC 1 -- ds50010--------
    rs793642191,2
    C,F--49311677(+) CATTCC/TTGAAT 1 -- ds50011Minor allele frequency- T:0.09WA 118
    rs1409167071,2
    --49311782(+) CCACTC/GGCTCC 1 -- ds50010--------
    rs38330631,2
    C--49311789(-) GGGAG-/GAGCCGGA 1 -- cds10--------
    rs711345841,2
    C--49311790(-) GGTCG-/GA    
       G
    /GGA
    GGAGC
    2 -- cds11NA 2
    rs37437771,2
    C,F,H--49312016(-) GTTCCC/TGAAGC 1 -- ut3118Minor allele frequency- T:0.22NS EA NA CSA WA 2340

    HapMap Linkage Disequilibrium report for CBLN1 (49311828 - 49315742 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CBLN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833221CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CBLN1
    DNA2.0 Custom Variant and Variant Library Synthesis for CBLN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600432    OMIM disorders: --

    6 diseases for CBLN1:    
    About MalaCards
    benign paroxysmal positional nystagmus    osteoporosis    cerebritis    prostate cancer
    prostatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for CBLN1:
    Benign paroxysmal positional nystagmus

    CBLN1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CBLN1
    Human Genome Epidemiology (HuGE) Navigator: CBLN1 (1 document)

    Export disorders for CBLN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CBLN1 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with CBLN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Precerebellin is a cerebellum-specific protein with similarity to the globular domain of complement C1q B chain. (PubMed id 1704129)1, 2, 3, 9 Urade Y.... Morgan J.I. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Genomic structure and mapping of precerebellin and a precerebellin-related gene. (PubMed id 7877445)1, 3 Kavety B....Morgan J.I. (Brain Res. Mol. Brain Res. 1994)
    4. Purification and characterisation of cerebellins from human and porcine cerebellum. (PubMed id 2760624)1, 2 Yiangou Y.... Bloom S.R. (J. Neurochem. 1989)
    5. Cerebellin stimulates the secretory activity of the rat adrenal gland: in vitro and in vivo studies. (PubMed id 10688962)1, 9 Albertin G....Nussdorfer G.G. (Neuropeptides 2000)
    6. Cerebellin enhances in vitro secretory activity of human adrenal gland. (PubMed id 10022429)1, 9 Mazzocchi G....Nussdorfer G.G. (J. Clin. Endocrinol. Metab. 1999)
    7. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)4 Tao S....Sun J. (Carcinogenesis 2012)
    8. Comparison of Cbln1 and Cbln2 functions using transgenic and knockout mice. (PubMed id 22117778)1 Rong Y....Morgan J.I. (J. Neurochem. 2012)
    9. Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study. (PubMed id 20200953)1 Karasik D....Demissie S. (J. Bone Miner. Res. 2010)
    10. Cbln1 is essential for interaction-dependent secretion of Cbln3. (PubMed id 17030622)1 Bao D....Morgan J.I. (Mol. Cell. Biol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 869 HGNC: 1543 AceView: CBLN1 Ensembl:ENSG00000102924 euGenes: HUgn869
    ECgene: CBLN1 H-InvDB: CBLN1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CBLN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CBLN1 gene:
    Search GeneIP for patents involving CBLN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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