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CBLL1 Gene

protein-coding   GIFtS: 56
GCID: GC07P107385

Cbl Proto-Oncogene-Like 1, E3 Ubiquitin Protein Ligase

(Previous name: Cas-Br-M (murine) ecotropic retroviral transforming sequence-like...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cbl Proto-Oncogene-Like 1, E3 Ubiquitin Protein Ligase1 2     Casitas B-Lineage Lymphoma-Like1
HAKAI2 3 5     Cbl Proto-Oncogene, E3 Ubiquitin Protein Ligase-Like 12
RNF1882 3 5     E-Cadherin Binding Protein E72
Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 11 2     E3 Ubiquitin-Protein Ligase Hakai2
Casitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 12 3     EC 6.3.2.-3
C-Cbl-Like Protein 12 3     EC 6.3.28
RING Finger Protein 1882 3     

External Ids:    HGNC: 212251   Entrez Gene: 798722   Ensembl: ENSG000001058797   OMIM: 6068725   UniProtKB: Q75N033   

Export aliases for CBLL1 gene to outside databases

Previous GC identifers: GC07P106931 GC07P106945 GC07P106978 GC07P107171 GC07P101746


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CBLL1 Gene:
This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis,
and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a
role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative
splicing results in a non-coding transcript variant. (provided by RefSeq, Aug 2011)

GeneCards Summary for CBLL1 Gene:
CBLL1 (Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is ZNF645.

UniProtKB/Swiss-Prot: HAKAI_HUMAN, Q75N03
Function: Promotes ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and
DOK1. Targets CDH1 for endocytosis and degradation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CBLL1 gene promoter:
         c-Fos   Spz1   AP-1   AML1a   JunB   Fra-1   FosB   CUTL1   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CBLL1 promoter sequence
   Search Chromatin IP Primers for CBLL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CBLL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.3   Ensembl cytogenetic band:  7q22.3   HGNC cytogenetic band: 7q22.3

CBLL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBLL1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P107385:  view genomic region     (about GC identifiers)

Start:
107,384,142 bp from pter      End:
107,402,112 bp from pter
Size:
17,971 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 106,745,399-106,763,197     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HAKAI_HUMAN, Q75N03 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase Hakai  
Size: 491 amino acids; 54519 Da
Subunit: Homodimer. Interacts with tyrosine-phosphorylated SRC substrates
Secondary accessions: Q8TAJ4 Q9H5S6

Explore the universe of human proteins at neXtProt for CBLL1: NX_Q75N03

Explore proteomics data for CBLL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CBLL1 (Q75N03) (see all 14)
     QHVPHEH  PVQRIEQC  SMAPPPPR  WPAPRGPPP 


    See CBLL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001271220.1  NP_079090.2  

    ENSEMBL proteins: 
     ENSP00000401277   ENSP00000401374   ENSP00000222597   ENSP00000401175   ENSP00000410615  

    CBLL1 Human Recombinant Protein Products:

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    Novus Biologicals CBLL1 Protein
    Novus Biologicals CBLL1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CBLL1

     
    Search eBioscience for Proteins for CBLL1 

     
    antibodies-online proteins for CBLL1 (6 products) 

     
    antibodies-online peptides for CBLL1

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    antibodies-online antibodies for CBLL1 (26 products) 

    CBLL1 Assay Products:

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    Cloud-Clone Corp. ELISAs for CBLL1
    Cloud-Clone Corp. CLIAs for CBLL1
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    antibodies-online kits for CBLL1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR015880 Znf_C2H2-like
     IPR017907 Znf_RING_CS

    Graphical View of Domain Structure for InterPro Entry Q75N03

    ProtoNet protein and cluster: Q75N03

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: HAKAI_HUMAN, Q75N03
    Domain: The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the
    recognition of its flanking acidic amino acids (By similarity)
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with CBLL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HAKAI_HUMAN, Q75N03
    Function: Promotes ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and
    DOK1. Targets CDH1 for endocytosis and degradation (By similarity)

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0004842ubiquitin-protein ligase activity TAS14996930
    GO:0005515protein binding IPI11836526
    GO:0008270zinc ion binding IEA--
    GO:0042802identical protein binding IEA--
         
    Find genes that share ontologies with CBLL1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CBLL1:
     Elongated cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CBLL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CBLL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CBLL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CBLL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CBLL1:
    hsa-mir-26b-5p (MIRT029151), hsa-mir-203a (MIRT007353)

    Block miRNA regulation of human, mouse, rat CBLL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CBLL1 (see all 98):
    hsa-miR-199a-3p hsa-miR-632 hsa-miR-519a hsa-miR-502-3p hsa-miR-4325 hsa-miR-629 hsa-miR-647 hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidCBLL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CBLL1
    Predesigned siRNA for gene silencing in human, mouse, rat CBLL1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CBLL1

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    OriGene ORF clones in mouse, rat for CBLL1
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    GenScript: all cDNA clones in your preferred vector: CBLL1 (NM_024814)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBLL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBLL1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CBLL1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IC14996930

    Find genes that share ontologies with CBLL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CBLL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Remodeling of Adherens Junctions
    Remodeling of Adherens Junctions

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CBLL1
        Remodeling of Adherens Junctions


    UniProtKB/Swiss-Prot: HAKAI_HUMAN, Q75N03
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CBLL1: 

              Adherens Junctions in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CBLL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for CBLL1 (Q75N032, 3 ENSP000004012774) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3MINT-3298028 I2D: score=1 
    CDH1P128303, ENSP000002617694I2D: score=3 STRING: ENSP00000261769
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    CDC42P609533, ENSP000003144584I2D: score=1 STRING: ENSP00000314458
    YWHAQP273483, ENSP000002380814I2D: score=1 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007162negative regulation of cell adhesion ISS--
    GO:0016337cell-cell adhesion IDA11836526
    GO:0016567protein ubiquitination TAS14996930
    GO:0030335positive regulation of cell migration ISS--
    GO:0045807positive regulation of endocytosis ISS--

    Find genes that share ontologies with CBLL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CBLL1 (HAKAI)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CBLL1 gene (2 alternative transcripts): 
    NM_001284291.1  NM_024814.3  

    Unigene Cluster for CBLL1:

    Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1
    Hs.592271  [show with all ESTs]
    Unigene Representative Sequence: NR_024199
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000440859(uc011kme.2 uc003veq.3 uc011kmf.2) ENST00000479443
    ENST00000432748 ENST00000222597 ENST00000493361 ENST00000487517 ENST00000415884
    ENST00000420796
    miRNA
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    Block miRNA regulation of human, mouse, rat CBLL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CBLL1 (see all 98):
    hsa-miR-199a-3p hsa-miR-632 hsa-miR-519a hsa-miR-502-3p hsa-miR-4325 hsa-miR-629 hsa-miR-647 hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidCBLL1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CBLL1
    Predesigned siRNA for gene silencing in human, mouse, rat CBLL1
    Clone
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    OriGene clones in human, mouse for CBLL1 (see all 7)
    OriGene ORF clones in mouse, rat for CBLL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CBLL1 (NM_024814)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBLL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBLL1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CBLL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBLL1
      QuantiTect SYBR Green Assays in human, mouse, rat CBLL1
      QuantiFast Probe-based Assays in human, mouse, rat CBLL1

    Additional mRNA sequence: 

    AK026762.1 AK293352.1 AK307992.1 BC027460.2 BC130529.1 BC130531.1 BC144176.1 NR_024199.1 

    5 DOTS entries:

    DT.40250069  DT.100647692  DT.95322156  DT.95360962  DT.92026774 

    Selected AceView cDNA sequences (see all 75):

    CR623864 BG288837 N89881 BP350093 BF439526 BG496198 BC027460 BU173348 
    BQ224139 BF056210 BG687056 CR608275 AW450317 AW299300 AA831893 BM683498 
    AI823954 BX089724 AW151683 BG392012 BP365877 BF589025 AI241080 BX437524 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CBLL1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:              -           -     -                           
    SP2:                          -     -                           
    SP3:                                                            
    SP4:                                                            
    SP5:                          -     -                           


    ECgene alternative splicing isoforms for CBLL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CBLL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGTCCACC
    CBLL1 Expression
    About this image


    CBLL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CBLL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CBLL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592271
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CBLL1: 
              Adherens Junctions in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CBLL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBLL1
    QuantiTect SYBR Green Assays in human, mouse, rat CBLL1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CBLL1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cbll11 , 5 Casitas B-lineage lymphoma-like 11, 5 93.75(n)1
    97.35(a)1
      12 (13.49 cM)5
    1048361  NM_001253847.11  NP_001240776.11 
     314848295 
    chicken
    (Gallus gallus)
    Aves CBLL11 Cbl proto-oncogene, E3 ubiquitin protein ligase-like more 81.67(n)
    89.61(a)
      417701  NM_001007848.1  NP_001007849.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    84(a)
    1 → many
    5(97627185-97648380)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.34842 Xenopus laevis transcribed sequence with moderate similarity more 80.63(n)    BU915495.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc553082 similar to Casitas B-lineage lymphoma-like 1 75.49(n)   394041  BC048028.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hakai6
    Hakai
    23(a)
    1 → many
    2L(19580612-19582474)


    ENSEMBL Gene Tree for CBLL1 (if available)
    TreeFam Gene Tree for CBLL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CBLL1 gene
    ZNF6452  
    1 SIMAP similar gene for CBLL1 using alignment to 6 protein entries:     HAKAI_HUMAN (see all proteins):
    ZNF645

    Find genes that share paralogs with CBLL1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CBLL1
    PGOHUM00000241523 PGOHUM00000241662


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CBLL1 (see all 436)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1444309041,2
    --107382340(+) TAAAGC/TAATGC 2 -- us2k10--------
    rs132243131,2
    C,F,H--107382352(+) TGAAAG/TTAAGA 2 -- us2k123Minor allele frequency- T:0.22NS EA NA WA 2530
    rs69690311,2
    C,F,H--107382380(+) AACAAA/TTGTTT 2 -- us2k15Minor allele frequency- T:0.01NS EA CSA 416
    rs78021811,2
    C,F,A,H--107382406(+) CTAAAA/GTAAGT 2 -- us2k1 tfbs317Minor allele frequency- G:0.18NA NS EA WA CSA 928
    rs1832851881,2
    --107382487(+) TTATAC/TAAAAT 2 -- us2k10--------
    rs1878681081,2
    --107382558(+) AATACG/TATTCT 2 -- us2k10--------
    rs1155363941,2
    F--107382596(+) TTAACC/TGTTAG 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs760766571,2
    C,F--107382662(+) ATCTGT/CAGTCC 2 -- us2k13Minor allele frequency- C:0.12CSA WA 122
    rs1502716861,2
    --107382736(+) CTATGA/GTTCTG 2 -- us2k10--------
    rs1386919011,2
    --107382742(+) TTCTGC/TCATTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CBLL1 (107384142 - 107402112 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CBLL1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CBLL1
    DNA2.0 Custom Variant and Variant Library Synthesis for CBLL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606872    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for CBLL1:
    tick-borne encephalitis     Yellow fever

    Find genes that share disorders with CBLL1           About GenesLikeMe

    Genetic Association Database (GAD): CBLL1
    Human Genome Epidemiology (HuGE) Navigator: CBLL1 (1 document)

    Export disorders for CBLL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CBLL1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with CBLL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    3. Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. (PubMed id 11836526)1, 3 Fujita Y....Birchmeier W. (Nat. Cell Biol. 2002)
    4. E-cadherin and Hakai: signalling, remodeling or destruction? (PubMed id 11944035)1, 3 Pece S. and Gutkind J.S. (Nat. Cell Biol. 2002)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. miR-203 regulates cell proliferation through its influence on Hakai expression. (PubMed id 23285092)1 Abella V....Figueroa A. (PLoS ONE 2012)
    7. Rack1 promotes epithelial cell-cell adhesion by regulating E-cadherin endocytosis. (PubMed id 21685945)1 Swaminathan G. and Cartwright C.A. (Oncogene 2012)
    8. Reduced surface expression of epithelial E-cadherin evoked by interferon-gamma is Fyn kinase-dependent. (PubMed id 22715382)1 Smyth D....McKay D.M. (PLoS ONE 2012)
    9. Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin. (PubMed id 22252131)1 Mukherjee M.... Sivaraman J. (EMBO J. 2012)
    10. Slit-Robo signaling induces malignant transformation through Hakai- mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis. (PubMed id 21283129)1 Zhou W.J.... Geng J.G. (Cell Res. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79872 HGNC: 21225 AceView: CBLL1 Ensembl:ENSG00000105879 euGenes: HUgn79872
    ECgene: CBLL1 H-InvDB: CBLL1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CBLL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CBLL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CBLL1 gene:
    Search GeneIP for patents involving CBLL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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