Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CBLL1 Gene

protein-coding   GIFtS: 54
GCID: GC07P107385

Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1

(Previous name: Cas-Br-M (murine) ecotropic retroviral transforming sequence-like...)
 Explore 7 diseases affiliated with
CBLL1 via our new
 Human Malady Compendium 
Biological research products
for CBLL1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cbl Proto-Oncogene, E3 Ubiquitin Protein Ligase-Like 11 2     RING Finger Protein 1882 3
HAKAI1 2 3 5     FLJ231091
RNF1881 2 3 5     E-Cadherin Binding Protein E72
Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 11 2     E3 Ubiquitin-Protein Ligase Hakai2
Casitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 12 3     EC 6.3.2.-3
C-Cbl-Like Protein 12 3     EC 6.3.28

External Ids:    HGNC: 212251   Entrez Gene: 798722   Ensembl: ENSG000001058797   OMIM: 6068725   UniProtKB: Q75N033   
ORGUL members:         
NONCODE:n406663    

Export aliases for CBLL1 gene to outside databases

Previous GC identifers: GC07P106931 GC07P106945 GC07P106978 GC07P107171 GC07P101746


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CBLL1:
This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and
degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in
control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results
in a non-coding transcript variant. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: HAKAI_HUMAN, Q75N03
Function: Promotes ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1.
Targets CDH1 for endocytosis and degradation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CBLL1 gene promoter:
         c-Fos   Spz1   AP-1   AML1a   JunB   Fra-1   FosB   CUTL1   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CBLL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CBLL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBLL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.3   Ensembl cytogenetic band:  7q22.3   HGNC cytogenetic band: 7q22.3

CBLL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBLL1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P107385:  view genomic region     (about GC identifiers)

Start:
107,384,142 bp from pter      End:
107,402,083 bp from pter
Size:
17,942 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 106,745,399-106,763,197     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HAKAI_HUMAN, Q75N03 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase Hakai  
Size: 491 amino acids; 54519 Da
Subunit: Homodimer. Interacts with tyrosine-phosphorylated SRC substrates
Secondary accessions: Q8TAJ4 Q9H5S6

Explore the universe of human proteins at neXtProt for CBLL1: NX_Q75N03

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q75N03

  • 4/14 DME Specific Peptides for CBLL1 (Q75N03) (see all 14)
     QHVPHEH  PVQRIEQC  SMAPPPPR  WPAPRGPPP 

    CBLL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_079090.2  
    ENSEMBL proteins: 
     ENSP00000401277   ENSP00000401374   ENSP00000222597   ENSP00000410615   ENSP00000401175  
     ENSP00000412126  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CBLL1
    OriGene Custom Protein Services for CBLL1 
    GenScript Custom Purified and Recombinant Proteins Services for CBLL1
    Novus Biologicals CBLL1 Protein
    Novus Biologicals CBLL1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CBLL1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IC14996930
    GO:0005622intracellular ----


    CBLL1 for ontologies           About GeneDecksing



    CBLL1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CBLL1 
    GenScript Custom Superior Antibodies Services for CBLL1
    Novus Biologicals CBLL1 Antibodies
    Search for Antibodies for CBLL1 at Abcam  
    Uscn Antibodies for CBLL1
    Search ThermoFisher Antibodies for CBLL1

    Assay Products for CBLL1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CBLL1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CBLL1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CBLL1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR015880 Znf_C2H2-like
     IPR017907 Znf_RING_CS

    Graphical View of Domain Structure for InterPro Entry Q75N03

    ProtoNet protein and cluster: Q75N03

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: HAKAI_HUMAN, Q75N03
    Domain: The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the recognition
    of its flanking acidic amino acids (By similarity)
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: HAKAI_HUMAN, Q75N03
    Function: Promotes ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1.
    Targets CDH1 for endocytosis and degradation (By similarity)

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: CBLL1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CBLL1
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate CBLL1 (see all 98):
    hsa-miR-199a-3p hsa-miR-632 hsa-miR-519a hsa-miR-502-3p hsa-miR-4325 hsa-miR-629 hsa-miR-647 hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidCBLL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CBLL1 (see all 7)
    OriGene shRNA RFP: CBLL1
    OriGene siRNA: CBLL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CBLL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CBLL1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBLL1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBLL1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CBLL1 (NM_024814)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBLL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBLL1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CBLL1
    Search LifeMap BioReagents cell lines for CBLL1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLL1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS14996930
    GO:0005515protein binding IPI11836526
    GO:0008270zinc ion binding IEA--


    CBLL1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CBLL1:
     Elongated cells 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Remodeling of Adherens Junctions
    Remodeling of Adherens Junctions1.00

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CBLL1
        Remodeling of Adherens Junctions


    UniProtKB/Swiss-Prot: HAKAI_HUMAN, Q75N03
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CBLL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/10 Interacting proteins for CBLL1 (Q75N032, 3 ENSP000004012774) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3MINT-3298028 I2D: score=1 
    CDH1P128303, ENSP000002617694I2D: score=3 STRING: ENSP00000261769
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    CDC42P609533, ENSP000003144584I2D: score=1 STRING: ENSP00000314458
    YWHAQP273483, ENSP000002380814I2D: score=1 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007162negative regulation of cell adhesion ISS--
    GO:0016337cell-cell adhesion IDA11836526
    GO:0016567protein ubiquitination TAS14996930
    GO:0030335positive regulation of cell migration ISS--
    GO:0045807positive regulation of endocytosis ISS--


    CBLL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CBLL1
    Search CenterWatch for drugs/clinical trials and news about CBLL1 / HAKAI 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CBLL1 gene: 
    NM_024814.2  

    Unigene Cluster for CBLL1:

    Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1
    Hs.592271  [show with all ESTs]
    Unigene Representative Sequence: NR_024199
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000440859(uc011kme.2 uc003veq.3 uc011kmf.2) ENST00000479443
    ENST00000432748 ENST00000222597 ENST00000493361 ENST00000487517 ENST00000420796
    ENST00000477356 ENST00000415884 ENST00000417616

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: CBLL1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CBLL1
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate CBLL1 (see all 98):
    hsa-miR-199a-3p hsa-miR-632 hsa-miR-519a hsa-miR-502-3p hsa-miR-4325 hsa-miR-629 hsa-miR-647 hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidCBLL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CBLL1 (see all 7)
    OriGene shRNA RFP: CBLL1
    OriGene siRNA: CBLL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CBLL1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBLL1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBLL1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CBLL1 (NM_024814)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBLL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBLL1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CBLL1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CBLL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBLL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBLL1

    Additional cDNA sequence: 

    AK026762.1 AK293352.1 AK307992.1 BC027460.2 BC130529.1 BC130531.1 BC144176.1 NR_024199.1 

    5 DOTS entries:

    DT.40250069  DT.100647692  DT.95322156  DT.95360962  DT.92026774 

    24/75 AceView cDNA sequences (see all 75):

    AW299300 BF439526 BC027460 BG496198 AI823954 BX089724 BG288837 BU173348 
    AA831893 BQ224139 AW151683 BM683498 BP350093 AW450317 BG687056 BF056210 
    CR623864 CR608275 N89881 AI055864 NM_024814 BX437524 CD651877 AW043930 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CBLL1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:              -           -     -                           
    SP2:                          -     -                           
    SP3:                                                            
    SP4:                                                            
    SP5:                          -     -                           


    ECgene alternative splicing isoforms for CBLL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CBLL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGTCCACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CBLL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CBLL1

    SOURCE GeneReport for Unigene cluster: Hs.592271
        SABiosciences Expression via Pathway-Focused PCR Arrays including CBLL1: 
              Adherens Junctions in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CBLL1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CBLL1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBLL1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBLL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CBLL1 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CBLL11 Cbl proto-oncogene, E3 ubiquitin protein ligase-like more 82.15(n)
    90.63(a)
      417701  NM_001007848.1  NP_001007849.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    89(a)
    1 → many
    5(97639568-97645224)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.34842 Xenopus laevis transcribed sequence with moderate similarity more 80.63(n)    BU915495.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc553082 similar to Casitas B-lineage lymphoma-like 1 75.49(n)   394041  BC048028.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hakai6
    Hakai
    21(a)
    1 → many
    2L(19580612-19582474)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G011606
    e-cadherin binding protein-like protein
    16(a)
    1 → many
    5(54010-55856)
    rice
    (Oryza sativa)
    Liliopsida --
    ZOS10-06 - C2H2 zinc finger protein, expressed
    14(a)
    1 → many
    10(18723094-18727119)


    ENSEMBL Gene Tree for CBLL1 (if available)
    TreeFam Gene Tree for CBLL1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CBLL1 gene
    ZNF6452  
    1 SIMAP similar gene for CBLL1 using alignment to 7 protein entries:     HAKAI_HUMAN (see all proteins):
    ZNF645

    CBLL1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CBLL1
    PGOHUM00000241523 PGOHUM00000241662


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/365 NCBI SNPs in CBLL1 are shown (see all 365    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1444309041,2
    --107382340(+) TAAAGC/TAATGC 2 -- us2k10--------
    rs132243131,2
    C,F,H,--107382352(+) TGAAAG/TTAAGA 2 -- us2k123Minor allele frequency- T:0.22NS EA NA WA 2530
    rs69690311,2
    C,F,H,--107382380(+) AACAAA/TTGTTT 2 -- us2k15Minor allele frequency- T:0.01NS EA CSA 416
    rs78021811,2
    C,F,A,H,--107382406(+) CTAAAA/GTAAGT 2 -- us2k1 tfbs317Minor allele frequency- G:0.18NA NS EA WA CSA 928
    rs1832851881,2
    --107382487(+) TTATAC/TAAAAT 2 -- us2k10--------
    rs1878681081,2
    --107382558(+) AATACG/TATTCT 2 -- us2k10--------
    rs1155363941,2
    F,--107382596(+) TTAACC/TGTTAG 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs760766571,2
    F,--107382662(+) ATCTGT/CAGTCC 2 -- us2k13Minor allele frequency- C:0.12CSA WA 122
    rs1502716861,2
    --107382736(+) CTATGA/GTTCTG 2 -- us2k10--------
    rs1386919011,2
    --107382742(+) TTCTGC/TCATTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CBLL1 (107384142 - 107402083 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CBLL1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CBLL1
    DNA2.0 Custom Variant and Variant Library Synthesis for CBLL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CBLL1 for disorders           About GeneDecksing

    OMIM gene information: 606872    OMIM disorders: --

    7 diseases for CBLL1:    About MalaCards
    tick-borne encephalitis    yellow fever    encephalitis    colon cancer
    breast carcinoma    breast cancer    carcinoma

    2 diseases from the University of Copenhagen DISEASES database for CBLL1:
    tick-borne encephalitis     Yellow fever
    Human Genome Epidemiology (HuGE) Navigator: CBLL1 (1 document)

    Export disorders for CBLL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CBLL1 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with CBLL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    2. Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. (PubMed id 11836526)1, 3 Fujita Y....Birchmeier W. (2002)
    3. E-cadherin and Hakai: signalling, remodeling or destruction? (PubMed id 11944035)1, 3 Pece S. and Gutkind J.S. (2002)
    4. Rack1 promotes epithelial cell-cell adhesion by regul ating E-cadherin endocytosis. (PubMed id 21685945)1 Swaminathan G. and Cartwright C.A. (2012)
    5. Reduced surface expression of epithelial E-cadherin ev oked by interferon-gamma is Fyn kinase-dependent. (PubMed id 22715382)1 Smyth D....McKay D.M. (2012)
    6. Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin. (PubMed id 22252131)1 Mukherjee M....Sivaraman J. (2012)
    7. Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis. (PubMed id 21283129)1 Zhou W.J....Geng J.G. (2011)
    8. Appraising the roles of CBLL1 and the ubiquitin/prote asome system for flavivirus entry and replication. (PubMed id 21191016)1 Fernandez-Garcia M.D....Amara A. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. Hakai acts as a coregulator of estrogen receptor alph a in breast cancer cells. (PubMed id 20608937)1 Gong E.Y....Lee K. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79872 HGNC: 21225 AceView: CBLL1 Ensembl:ENSG00000105879 euGenes: HUgn79872
    ECgene: CBLL1 H-InvDB: CBLL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CBLL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CBLL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CBLL1 gene:
    Search GeneIP for patents involving CBLL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CBLL1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CBLL1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CBLL1  
     OriGene Protein Over-expression Lysate for CBLL1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CBLL1   OriGene 3'-UTR Clone for CBLL1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBLL1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBLL1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CBLL1   OriGene Custom Protein Services for CBLL1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CBLL1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CBLL1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBLL1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CBLL1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBLL1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBLL1
     GenScript Custom Purified and Recombinant Proteins Services for CBLL1 GenScript cDNA clones with any tag delivered in your preferred vector for CBLL1
     GenScript Custom Assay Services for CBLL1 GenScript Custom Superior Antibodies Services for CBLL1
     GenScript Custom overexpressing Cell Line Services for CBLL1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CBLL1 promoter
     Search Chromatin IP Primers for CBLL1
     RT2 qPCR Primer Assay in human, mouse, rat CBLL1
     Search GNC Networks for CBLL1
     SABiosciences PCR Arrays including human, mouse, rat CBLL1
     Search Tocris compounds for CBLL1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CBLL1 antibodies
     CBLL1 proteins
     CBLL1 lysates
     Search for Antibodies for CBLL1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CBLL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CBLL1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CBLL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLL1
     SwitchGear 3'UTR luciferase reporter plasmids for CBLL1
     SwitchGear Promoter luciferase reporter plasmids for CBLL1
     Search ThermoFisher Antibodies for CBLL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBLL1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CBLL1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4