Aliases for CBLL1 Gene
External Ids for CBLL1 Gene
Previous GeneCards Identifiers for CBLL1 Gene
This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]
GeneCards Summary for CBLL1 Gene
CBLL1 (Cbl Proto-Oncogene-Like 1, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Remodeling of Adherens Junctions. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is ZNF645.
UniProtKB/Swiss-Prot for CBLL1 Gene
Promotes ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation (By similarity).