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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CBLC Gene

protein-coding   GIFtS: 55
GCID: GC19P045281

Cbl proto-oncogene, E3 ubiquitin protein ligase C

(Previous names: Cas-Br-M (murine) ectropic retroviral transforming sequence...)
 Explore 6 diseases affiliated with
CBLC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CBLC    

Aliases
for CBLC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cbl Proto-Oncogene, E3 Ubiquitin Protein Ligase C1 2     RING Finger Protein 572 3
RNF571 2 3     SH3-Binding Protein CBL-32 3
CBL-31 2     SH3-Binding Protein CBL-C2 3
CBL-SL1 2     Signal Transduction Protein CBL-C2
Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence C1 2     CBL33
Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence C1 2     

External Ids:    HGNC: 159611   Entrez Gene: 236242   Ensembl: ENSG000001422737   OMIM: 6084535   UniProtKB: Q9ULV83   

Export aliases for CBLC gene to outside databases

Previous GC identifers: GC19P045925 GC19P045672 GC19P049957 GC19P049972 GC19P041713


Summaries
for CBLC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CBLC:
This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell
signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be
restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been
observed for this gene. (provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: CBLC_HUMAN, Q9ULV8
Function: Regulator of EGFR mediated signal transduction

Gene Wiki entry for CBLC


Genomic Views
for CBLC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CBLC gene promoter:
         p300   HTF   GCNF   AP-4   XBP-1   AP-2gamma   HEN1   NRF-2   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CBLC promoter sequence
   Search SABiosciences Chromatin IP Primers for CBLC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBLC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.2

CBLC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBLC gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045281:  view genomic region     (about GC identifiers)

Start:
 45,281,126 bp from pter      End:
 45,303,903 bp from pter
Size:
 22,778 bases      Orientation:
 plus strand

Proteins
for CBLC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CBLC_HUMAN, Q9ULV8 (See protein sequence)
Recommended Name: Signal transduction protein CBL-C  
Size: 474 amino acids; 52456 Da
Subunit: Interacts with EGFR (tyrosine phosphorylated). Interacts with a restricted range of SH3 domain proteins
Subcellular location: Nucleus (Potential)
Miscellaneous: This protein has one functional calcium-binding site (By similarity)
1 PDB 3D structure from and Proteopedia for CBLC:
3OP0 (3D)    
Secondary accessions: Q8N1E5 Q9Y5Z2 Q9Y5Z3
Alternative splicing: 2 isoforms:  Q9ULV8-1   Q9ULV8-2   

Explore the universe of human proteins at neXtProt for CBLC: NX_Q9ULV8

Post-translational modifications:

  • Phosphorylated on tyrosines by EGFR1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9ULV8

    • CBLC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001124324.1  NP_036248.3  

    ENSEMBL proteins: 
     ENSP00000270279   ENSP00000340250  

    Human Recombinant Protein Products: 
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    Novus Biologicals CBLC Protein
    Novus Biologicals CBLC Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CBLC

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    CBLC for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CBLC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CBLC for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR001841 Znf_RING
     IPR011992 EF-hand-like_dom
     IPR014742 Adaptor_Cbl_SH2-like
     IPR024162 Adaptor_Cbl
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9ULV8

    ProtoNet protein and cluster: Q9ULV8

    2 Blocks protein families:
    IPB001841 Zn-finger
    IPB003153 Adaptor protein Cbl


    UniProtKB/Swiss-Prot: CBLC_HUMAN, Q9ULV8
    Domain: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type
    zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different
    subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain
    Domain: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)
    Similarity: Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain
    Similarity: Contains 1 RING-type zinc finger


    Function
    for CBLC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CBLC_HUMAN, Q9ULV8
    Function: Regulator of EGFR mediated signal transduction

    miRNA
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    hsa-miR-4283 hsa-miR-3176 hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CBLC 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: CBLC
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CBLC

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBLC (see all 5)
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    Cell Line
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001784phosphotyrosine binding IDA14661060
    GO:0004842ubiquitin-protein ligase activity IDA14661060
    GO:0004871signal transducer activity IEA--
    GO:0005154epidermal growth factor receptor binding IDA10362357
    GO:0005509calcium ion binding IEA--


    CBLC for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cblc):
     normal 

    CBLC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CBLC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1ErbB signaling pathway
    		ErbB signaling pathway1.00
    		ErbB signaling pathway0.51
    2Insulin Signaling
    		Insulin Signaling1.00
    3EGFR1 Signaling Pathway
    		EGFR1 Signaling Pathway1.00
    4Chronic myeloid leukemia
    		Chronic myeloid leukemia1.00
    5Pathways in cancer
    		Pathways in cancer1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for CBLC 
        EGFR1 Signaling Pathway
    ErbB signaling pathway
    Insulin Signaling


    5/9         Kegg Pathways  (Kegg details for CBLC) (see all 9):
        ErbB signaling pathway
    Ubiquitin mediated proteolysis
    Endocytosis
    Jak-STAT signaling pathway
    T cell receptor signaling pathway


    CBLC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CBLC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/104 Interacting proteins for CBLC (Q9ULV82, 3 ENSP000002702794) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J022, 3, ENSP000003639984MINT-58341 MINT-58330 MINT-58290 MINT-58329 MINT-58340 I2D: score=2 STRING: ENSP00000363998
    SHC1P293532, 3, ENSP000004013034MINT-8250712 I2D: score=2 STRING: ENSP00000401303
    ABI1Q8IZP02, 3, ENSP000003653124MINT-7908378 I2D: score=1 STRING: ENSP00000365312
    NACADO150692, 3MINT-8250690 I2D: score=2 
    SH3GL3Q999632, 3MINT-8250701 I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway IEA--
    GO:0007175negative regulation of epidermal growth factor-activated receptor activity IDA10362357
    GO:0042059negative regulation of epidermal growth factor receptor signaling pathway IDA10362357
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA14661060
    GO:0043407negative regulation of MAP kinase activity IDA10362357


    CBLC for ontologies           About GeneDecksing



    Drugs & Compounds
    for CBLC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CBLC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CBLC

    5 HMDB Compounds for CBLC    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    1 Novoseek chemical compound relationship for CBLC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 43.4 1 12177062 (1)

    Search CenterWatch for drugs/clinical trials and news about CBLC 

    Transcripts
    for CBLC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CBLC gene (2 alternative transcripts): 
    NM_001130852.1  NM_012116.3  

    Unigene Cluster for CBLC:

    Cbl proto-oncogene, E3 ubiquitin protein ligase C
    Hs.466907  [show with all ESTs]
    Unigene Representative Sequence: NM_012116
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000270279(uc002ozs.3) ENST00000341505(uc010ejt.3)

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CBLC:
    hsa-miR-4283 hsa-miR-3176 hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CBLC 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CBLC (see all 7)
    OriGene shRNA RFP: CBLC
    OriGene siRNA: CBLC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CBLC
    Clone
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    Primer
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    Additional cDNA sequence: 

    AB028645.1 AF117646.1 AF117647.1 BC028915.1 

    4 DOTS entries:

    DT.40198635  DT.91671842  DT.100736481  DT.86857280 

    24/38 AceView cDNA sequences (see all 38):

    AI801220 BM018276 BE794642 BG742803 BM791657 BM770422 BM831524 BM770284 
    BC028915 AI758472 AW293215 AI368245 BE900379 BM746909 BE464528 AF117646 
    AI660567 NM_012116 BM857034 AF117647 BG248143 AB028645 BE903324 AA112513 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CBLC    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                  
    SP2:                          -                                       


    ECgene alternative splicing isoforms for CBLC

    Expression
    for CBLC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CBLC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACTCCACAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CBLC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CBLC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CBLC

    SOURCE GeneReport for Unigene cluster: Hs.466907

    UniProtKB/Swiss-Prot: CBLC_HUMAN, Q9ULV8
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including CBLC: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLC

    Orthologs
    for CBLC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CBLC gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cblc1 , 5 Casitas B-lineage lymphoma c1, 5 79.86(n)1
    75.57(a)1    		   7 (9.94 cM)5
    807941  NM_023224.51  NP_075713.31 
     197788815 
    lizard
    (Anolis carolinensis)    		 Reptilia CBLC6
    		 --
    		 56(a)
    		 1 ↔ 1
    		 AAWZ02037515(4429-15349)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1721626
    		 zgc:172162
    		 42(a)
    		 1 ↔ 1
    		 16(28000382-28040099)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cbl6
    		 Cbl
    		 23(a)
    		 1 → many
    		 3L(8418054-8425346)
    worm
    (Caenorhabditis elegans)    		 Secernentea sli-16
    		 Suppressor of LIneage defect family member (sli-1)...
    		 32(a)
    		 1 → many
    		 X(720325-725956)


    ENSEMBL Gene Tree for CBLC (if available)
    TreeFam Gene Tree for CBLC (if available) 

    Paralogs
    for CBLC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CBLC gene
    CBLB2  CBL2  
    2 SIMAP similar genes for CBLC using alignment to 1 protein entry:     CBLC_HUMAN:
    CBLB    CBL

    CBLC for paralogs           About GeneDecksing



    Genomic Variants
    for CBLC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/574 NCBI SNPs in CBLC are shown (see all 574)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1133758791,2
    		--41713653(+) GAACTC/TAGGCC 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs1126459921,2
    		C,F,--41713681(+) CAGACC/ACAGGA 1 -- int11Minor allele frequency- A:0.12WA 118
    rs65091711,2
    		C,A,--45279157(+) CCAGCA/GTTGTG 2 -- us2k12Minor allele frequency- G:0.23WA 120
    rs1929271321,2
    		--45279296(+) GTAGTC/TCTAGT 2 -- us2k10--------
    rs29651431,2
    		C,F,A,--45279340(+) GCCCCA/GGAGGT 2 -- us2k16Minor allele frequency- G:0.30NA CSA WA EA 362
    rs106754881,2
    		C,--45279419(+) tcaaa-/AAAAT 
                aaaat     		2 -- us2k10--------
    rs1433782951,2
    		--45279499(+) ATTTGC/TGATCA 2 -- us2k10--------
    rs1483771521,2
    		--45279730(+) GGCGCA/GGCCAG 2 -- us2k10--------
    rs1851219241,2
    		--45279762(+) GCCCAC/TAGCGC 2 -- us2k10--------
    rs1423076751,2
    		--45279916(+) TTCTTC/TGGGAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CBLC (45281126 - 45303903 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CBLC: --

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    Disorders / Diseases
    for CBLC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CBLC for disorders           About GeneDecksing

    OMIM gene information: 608453    OMIM disorders: --

    6 diseases for CBLC:    About MalaCards
    cblc    chronic myeloid leukemia    myeloid leukemia    myeloid malignancy
    colon cancer    leukemia


    Export disorders for CBLC gene to outside databases

    Publications
    for CBLC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CBLC gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with CBLC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cbl-3: a new mammalian cbl family protein. (PubMed id 10362357)1, 2, 3, 9 Keane M.M.... Lipkowitz S. (1999)
    2. Molecular cloning and characterization of a novel cbl-family gene, cbl-c. (PubMed id 10571044)1, 2, 3 Kim M.... Yamamoto T. (1999)
    3. CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction. (PubMed id 18753381)1, 9 Tsui C.C. and Pierchala B.A. (2008)
    4. CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. (PubMed id 12177062)1, 9 Szymkiewicz I....Dikic I. (2002)
    5. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    6. Structural flexibility regulates phosphopeptide-bindin g activity of the tyrosine kinase binding domain of Cbl-c. (PubMed id 22888118)1 Takeshita K....Nakagawa A. (2012)
    7. CBL mutations in myeloproliferative neoplasms are also found in the gene's proline-rich domain and in patients with the V617FJAK2. (PubMed id 22315494)1 Aranaz P....Vizmanos J.L. (2012)
    8. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. The N terminus of Cbl-c regulates ubiquitin ligase ac tivity by modulating affinity for the ubiquitin-conjugating enzyme. (PubMed id 20525694)1 Ryan P.E....Lipkowitz S. (2010)

    External Searches for CBLC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CBLC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23624 HGNC: 15961 AceView: CBLC Ensembl:ENSG00000142273 euGenes: HUgn23624
    ECgene: CBLC Kegg: 23624 H-InvDB: CBLC

    Other Databases showing CBLC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CBLC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CBLC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CBLC Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CBLC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CBLC gene:
    Search GeneIP for patents involving CBLC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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