Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CBLC Gene

protein-coding   GIFtS: 55
GCID: GC19P045281

Cbl Proto-Oncogene C, E3 Ubiquitin Protein Ligase

(Previous names: Cas-Br-M (murine) ectropic retroviral transforming sequence...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cbl Proto-Oncogene C, E3 Ubiquitin Protein Ligase1 2     SH3-Binding Protein CBL-C2 3
Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence C1 2     CBL-32
Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence C1 2     CBL-SL2
RNF572 3     Cbl Proto-Oncogene, E3 Ubiquitin Protein Ligase C2
RING Finger Protein 572 3     Signal Transduction Protein CBL-C2
SH3-Binding Protein CBL-32 3     CBL33

External Ids:    HGNC: 159611   Entrez Gene: 236242   Ensembl: ENSG000001422737   OMIM: 6084535   UniProtKB: Q9ULV83   

Export aliases for CBLC gene to outside databases

Previous GC identifers: GC19P045925 GC19P045672 GC19P049957 GC19P049972 GC19P041713


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CBLC Gene:
This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell
signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene
may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms
have been observed for this gene. (provided by RefSeq, Feb 2012)

GeneCards Summary for CBLC Gene: 
CBLC (Cbl proto-oncogene C, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with CBLC include cblc, and disorders of intracellular cobalamin metabolism, and among its related super-pathways are ErbB signaling pathway and Pancreatic cancer. GO annotations related to this gene include signal transducer activity and calcium ion binding. An important paralog of this gene is CBLB.

UniProtKB/Swiss-Prot: CBLC_HUMAN, Q9ULV8
Function: Regulator of EGFR mediated signal transduction

Gene Wiki entry for CBLC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CBLC gene promoter:
         p300   HTF   GCNF   AP-4   XBP-1   AP-2gamma   HEN1   NRF-2   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCBLC promoter sequence
   Search SABiosciences Chromatin IP Primers for CBLC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBLC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.2

CBLC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBLC gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045281:  view genomic region     (about GC identifiers)

Start:
45,281,126 bp from pter      End:
45,303,903 bp from pter
Size:
22,778 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CBLC_HUMAN, Q9ULV8 (See protein sequence)
Recommended Name: Signal transduction protein CBL-C  
Size: 474 amino acids; 52456 Da
Subunit: Interacts with EGFR (tyrosine phosphorylated). Interacts with a restricted range of SH3 domain proteins
Subcellular location: Nucleus (Potential)
Miscellaneous: This protein has one functional calcium-binding site (By similarity)
6 PDB 3D structures from and Proteopedia for CBLC:
3OP0 (3D)        3VRN (3D)        3VRO (3D)        3VRP (3D)        3VRQ (3D)        3VRR (3D)    
Secondary accessions: Q8N1E5 Q9Y5Z2 Q9Y5Z3
Alternative splicing: 2 isoforms:  Q9ULV8-1   Q9ULV8-2   

Explore the universe of human proteins at neXtProt for CBLC: NX_Q9ULV8

Explore proteomics data for CBLC at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosines by EGFR
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9ULV8

  • CBLC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CBLC Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001124324.1  NP_036248.3  

    ENSEMBL proteins: 
     ENSP00000270279   ENSP00000340250  

    Human Recombinant Protein Products for CBLC: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CBLC
    OriGene Protein Over-expression Lysate for CBLC
    OriGene MassSpec for CBLC 
    OriGene Custom Protein Services for CBLC
    GenScript Custom Purified and Recombinant Proteins Services for CBLC
    Novus Biologicals CBLC Protein
    Novus Biologicals CBLC Lysate
    Sino Biological Recombinant Protein for CBLC
    Sino Biological Cell Lysate for CBLC 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    CBLC for ontologies           About GeneDecksing



    CBLC Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CBLC
    OriGene Custom Antibody Services for CBLC
    GenScript Custom Superior Antibodies Services for CBLC
    Novus Biologicals CBLC Antibodies
    Abcam antibodies for CBLC
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for CBLC
    LSBio Antibodies in human, mouse, rat for CBLC 

    Assay Products for CBLC: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CBLC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CBLC
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5/10 InterPro protein domains (see all 10):
     IPR001841 Znf_RING
     IPR011992 EF-hand-like_dom
     IPR014742 Adaptor_Cbl_SH2-like
     IPR024162 Adaptor_Cbl
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9ULV8

    ProtoNet protein and cluster: Q9ULV8

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB003153 Adaptor protein Cbl


    UniProtKB/Swiss-Prot: CBLC_HUMAN, Q9ULV8
    Domain: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the
    RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of
    three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain
    Domain: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)
    Similarity: Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain
    Similarity: Contains 1 RING-type zinc finger


    CBLC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBLC_HUMAN, Q9ULV8
    Function: Regulator of EGFR mediated signal transduction

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001784phosphotyrosine binding IDA14661060
    GO:0004842ubiquitin-protein ligase activity IDA14661060
    GO:0004871signal transducer activity IEA--
    GO:0005154epidermal growth factor receptor binding IDA10362357
    GO:0005509calcium ion binding IEA--
         
    CBLC for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cblc):
     normal 

    CBLC for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CBLC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CBLC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CBLC 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CBLC 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CBLC
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CBLC:
    hsa-miR-4283 hsa-miR-3176 hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidCBLC 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CBLC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CBLC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CBLC
    Sirion Biotech Customized adenovirus for overexpression of CBLC

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CBLC (see all 14)
    OriGene ORF clones in mouse, rat for CBLC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CBLC (NM_001130852)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBLC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBLC
    Sirion Biotech Customized lentivirus for stable overexpression of CBLC 
                         Customized lentivirus expression plasmids for stable overexpression of CBLC 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CBLC
    Search LifeMap BioReagents cell lines for CBLC
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CBLC About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    ErbB signaling pathway0.52
    2Chronic myeloid leukemia
    Chronic myeloid leukemia0.42
    3B cell receptor signaling pathway
    T cell receptor signaling pathway0.38
    4Antigen processing: Ubiquitination & Proteasome degradation
    Ubiquitin mediated proteolysis0.36
    5Translation Insulin regulation of translation
    Insulin signaling pathway0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for CBLC
        EGFR1 Signaling Pathway
    Insulin Signaling
    ErbB signaling pathway



    5/10         Kegg Pathways  (Kegg details for CBLC) (see all 10):
        ErbB signaling pathway
    Ubiquitin mediated proteolysis
    Endocytosis
    Jak-STAT signaling pathway
    T cell receptor signaling pathway


    CBLC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CBLC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/104 Interacting proteins for CBLC (Q9ULV82, 3 ENSP000002702794) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J022, 3, ENSP000003639984MINT-58341 MINT-58330 MINT-58290 MINT-58329 MINT-58340 I2D: score=2 STRING: ENSP00000363998
    SHC1P293532, 3, ENSP000004013034MINT-8250712 I2D: score=2 STRING: ENSP00000401303
    ABI1Q8IZP02, 3, ENSP000003653124MINT-7908378 I2D: score=1 STRING: ENSP00000365312
    NACADO150692, 3MINT-8250690 I2D: score=2 
    SH3GL3Q999632, 3MINT-8250701 I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway IEA--
    GO:0007175negative regulation of epidermal growth factor-activated receptor activity IDA10362357
    GO:0042059negative regulation of epidermal growth factor receptor signaling pathway IDA10362357
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA14661060
    GO:0043407negative regulation of MAP kinase activity IDA10362357

    CBLC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CBLC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CBLC

    5 HMDB Compounds for CBLC    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 Novoseek inferred chemical compound relationship for CBLC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 43.4 1 12177062 (1)

    Search CenterWatch for drugs/clinical trials and news about CBLC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CBLC gene (2 alternative transcripts): 
    NM_001130852.1  NM_012116.3  

    Unigene Cluster for CBLC:

    Cbl proto-oncogene, E3 ubiquitin protein ligase C
    Hs.466907  [show with all ESTs]
    Unigene Representative Sequence: NM_012116
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000270279(uc002ozs.3) ENST00000341505(uc010ejt.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CBLC
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CBLC:
    hsa-miR-4283 hsa-miR-3176 hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidCBLC 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CBLC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CBLC
    Clone
    Products:
         
    OriGene clones in human, mouse for CBLC (see all 14)
    OriGene ORF clones in mouse, rat for CBLC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CBLC (NM_001130852)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBLC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBLC
    Sirion Biotech Customized lentivirus for stable overexpression of CBLC 
                         Customized lentivirus expression plasmids for stable overexpression of CBLC 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CBLC
    OriGene qSTAR qPCR primer pairs in human, mouse for CBLC
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CBLC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBLC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBLC

    Additional mRNA sequence: 

    AB028645.1 AF117646.1 AF117647.1 BC028915.1 

    4 DOTS entries:

    DT.40198635  DT.91671842  DT.100736481  DT.86857280 

    24/38 AceView cDNA sequences (see all 38):

    BC028915 AI801220 BE794642 BG742803 AI758472 BM791657 BM018276 BM831524 
    BM770284 BM770422 NM_012116 AW293215 AI660567 BG248143 AF117647 AB028645 
    BM746909 AI368245 AF117646 BE464528 BM857034 BE900379 BE735303 BM852708 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CBLC    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                  
    SP2:                          -                                       


    ECgene alternative splicing isoforms for CBLC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CBLC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTCCACAT
    CBLC Expression
    About this image


    See CBLC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CBLC

    SOURCE GeneReport for Unigene cluster: Hs.466907

    UniProtKB/Swiss-Prot: CBLC_HUMAN, Q9ULV8
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including CBLC: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CBLC
    OriGene qSTAR qPCR primer pairs in human, mouse for CBLC
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CBLC
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBLC
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBLC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CBLC gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cblc1 , 5 Casitas B-lineage lymphoma c1, 5 79.86(n)1
    75.57(a)1
      7 (9.94 cM)5
    807941  NM_023224.51  NP_075713.31 
     197788815 
    lizard
    (Anolis carolinensis)
    Reptilia CBLC6
    Uncharacterized protein
    51(a)
    1 ↔ 1
    AAWZ02037515(2344-15485)
    zebrafish
    (Danio rerio)
    Actinopterygii CBLC6
    Cbl proto-oncogene, E3 ubiquitin protein ligase C
    39(a)
    1 ↔ 1
    16(28000382-28040099)
    fruit fly
    (Drosophila melanogaster)
    Insecta Cbl6
    Cbl
    21(a)
    1 → many
    3L(8418054-8425346)
    worm
    (Caenorhabditis elegans)
    Secernentea sli-16
    Protein SLI-1, isoform c
    30(a)
    1 → many
    X(720326-725957)


    ENSEMBL Gene Tree for CBLC (if available)
    TreeFam Gene Tree for CBLC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CBLC gene
    CBLB2  CBL2  
    2 SIMAP similar genes for CBLC using alignment to 1 protein entry:     CBLC_HUMAN:
    CBLB    CBL

    CBLC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/742 SNPs in CBLC are shown (see all 742)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs129770541,2
    C--41736182(+) atactG/Ccagcc 2 -- ds50011Minor allele frequency- C:0.00NA 2
    rs29651101,2
    C--41736227(-) gggagA/Gagggg 2 -- ds50010--------
    rs29274401,2
    C--41736276(-) ctcctA/Gggtct 2 -- ds50010--------
    rs65091711,2
    C,A--45279157(+) ccagcA/Gttgtg 2 -- us2k12Minor allele frequency- G:0.23WA 120
    rs3698698361,2
    C--45279247(+) AAAAA-/CTAAAAA 2 -- us2k10--------
    rs1929271321,2
    --45279296(+) GTAGTC/TCTAGT 2 -- us2k10--------
    rs29651431,2
    C,F,A--45279340(+) gccccA/Ggaggt 2 -- us2k16Minor allele frequency- G:0.30NA CSA WA EA 362
    rs106754881,2
    C--45279419(+) tcaaa-/AAAAT 
            
    aaaat
    2 -- us2k10--------
    rs358396431,2
    C--45279420(+) CAAAA-/AAAAT 
            
    AAATA
    2 -- us2k10--------
    rs1433782951,2
    --45279499(+) ATTTGC/TGATCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CBLC (45281126 - 45303903 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CBLC:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833841CNV Loss17160897
    nsv912116CNV Loss21882294
    nsv2506CNV Loss18451855
    dgv3945n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CBLC
    DNA2.0 Custom Variant and Variant Library Synthesis for CBLC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608453    OMIM disorders: --

    6 diseases for CBLC:    About MalaCards
    cblc    disorders of intracellular cobalamin metabolism    chronic myeloid leukemia    myeloid leukemia
    colon cancer    leukemia


    CBLC for disorders           About GeneDecksing


    Export disorders for CBLC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CBLC gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with CBLC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cbl-3: a new mammalian cbl family protein. (PubMed id 10362357)1, 2, 3, 9 Keane M.M.... Lipkowitz S. (1999)
    2. Molecular cloning and characterization of a novel cbl-family gene, cbl-c. (PubMed id 10571044)1, 2, 3 Kim M.... Yamamoto T. (1999)
    3. CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction. (PubMed id 18753381)1, 9 Tsui C.C. and Pierchala B.A. (2008)
    4. CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. (PubMed id 12177062)1, 9 Szymkiewicz I....Dikic I. (2002)
    5. Cbl-c ubiquitin ligase activity is increased via the i nteraction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5. (PubMed id 23145173)1 Ryan P.E....Lipkowitz S. (2012)
    6. Structural flexibility regulates phosphopeptide-bindin g activity of the tyrosine kinase binding domain of Cbl-c. (PubMed id 22888118)1 Takeshita K....Nakagawa A. (2012)
    7. Direct and indirect control of mitogen-activated prote in kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/R AF1 kinase, by the deubiquitylating enzyme USP15. (PubMed id 23105109)1 Hayes S.D....Urbe S. (2012)
    8. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    9. CBL mutations in myeloproliferative neoplasms are also found in the gene's proline-rich domain and in patients with the V617FJAK2. (PubMed id 22315494)1 Aranaz P....Vizmanos J.L. (2012)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23624 HGNC: 15961 AceView: CBLC Ensembl:ENSG00000142273 euGenes: HUgn23624
    ECgene: CBLC Kegg: 23624 H-InvDB: CBLC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CBLC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CBLC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CBLC gene:
    Search GeneIP for patents involving CBLC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CBLC   OriGene RNAi products in human, mouse, rat for CBLC  
     OriGene qPCR primer pairs and template standards for CBLC   OriGene Protein Over-expression Lysate for CBLC  
     OriGene MassSpec something-or-other for CBLC   OriGene clones in human, mouse for CBLC  
     OriGene qSTAR qPCR primer pairs in human, mouse for CBLC   OriGene Purified Protein for CBLC  
     OriGene ORF clones in mouse, rat for CBLC   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CBLC   OriGene Custom Protein Services for CBLC  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CBLC
     QIAGEN SeqTarget long-range PCR primers for resequencing CBLC
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBLC
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CBLC
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBLC
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBLC
     GenScript Custom Purified and Recombinant Proteins Services for CBLC GenScript cDNA clones with any tag delivered in your preferred vector for CBLC
     GenScript Custom Assay Services for CBLC GenScript Custom Superior Antibodies Services for CBLC
     GenScript Custom overexpressing Cell Line Services for CBLC CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CBLC promoter
     Search Chromatin IP Primers for CBLC
     RT2 qPCR Primer Assay in human, mouse, rat CBLC
     GNC Network for CBLC
     SABiosciences PCR Arrays including human, mouse, rat CBLC
     Search Tocris compounds for CBLC
     Proteins and Antibodies for CBLC
     Cell Lysates for CBLC
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CBLC antibodies
     CBLC proteins
     CBLC lysates
     Antibodies for CBLC
     See all of Abcam's Antibodies, Kits and Proteins for CBLC
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CBLC
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLC
     SwitchGear 3'UTR luciferase reporter plasmids for CBLC
     SwitchGear Promoter luciferase reporter plasmids for CBLC
     Search ThermoFisher Antibodies for CBLC
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBLC
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CBLC
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CBLC
    Customized:
     lentivirus for stable overexpression of CBLC
     lentivirus expression plasmids for stable overexpression of CBLC
     adenovirus for overexpression of CBLC
     LSBio Antibodies in human, mouse, rat for CBLC
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CBLC gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4