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CBLB Gene

protein-coding   GIFtS: 67
GCID: GC03M105374

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase

(Previous names: Cas-Br-M (murine) ectropic retroviral transforming sequence...)
  See CBLB-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase1 2     SH3-Binding Protein CBL-B2 3
Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B1 2     Cbl-b2
Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence B1 2     Cbl Proto-Oncogene, E3 Ubiquitin Protein Ligase B2
Casitas B-Lineage Lymphoma Proto-Oncogene B2 3     E3 Ubiquitin-Protein Ligase CBL-B2
Signal Transduction Protein CBL-B2 3     EC 6.3.2.-3
RNF562 3     EC 6.3.28
RING Finger Protein 562 3     

External Ids:    HGNC: 15421   Entrez Gene: 8682   Ensembl: ENSG000001144237   OMIM: 6044915   UniProtKB: Q131913   

Export aliases for CBLB gene to outside databases

Previous GC identifers: GC03M102013 GC03M104895 GC03M106658 GC03M106698 GC03M106859 GC03M102751


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CBLB Gene:
CBLB (Cbl proto-oncogene B, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with CBLB include cannabis dependence. GO annotations related to this gene include signal transducer activity and calcium ion binding. An important paralog of this gene is CBLC.

UniProtKB/Swiss-Prot: CBLB_HUMAN, Q13191
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and
transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR
(T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal
transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement
for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination,
which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1
activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating
SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR
ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3

Gene Wiki entry for CBLB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CBLB gene promoter:
         TBP   Pax-6   RelA   NF-kappaB   E4BP4   S8   deltaCREB   TFIID   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCBLB promoter sequence
   Search Chromatin IP Primers for CBLB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CBLB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.11   Ensembl cytogenetic band:  3q13.11   HGNC cytogenetic band: 3q

CBLB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBLB gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M105374:  view genomic region     (about GC identifiers)

Start:
105,374,305 bp from pter      End:
105,588,396 bp from pter
Size:
214,092 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CBLB_HUMAN, Q13191 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase CBL-B  
Size: 982 amino acids; 109450 Da
Subunit: Interacts with SH3 domain-containing proteins LCK, CRK and SORBS1. Interacts with LCP2 and ZAP70. May
interact with CBL. Interacts with SH3 domain-containing proteins VAV1, FYN, FGR, PLCG1, GRB2, CRKL, PIK3R1 and
SH3KBP1/CIN85. Identified in heterotrimeric complexes with SH3KBP1/CIN85, CD2AP and ARHGEF7, where one CBLB
peptide binds two copies of the other protein. Interacts with poly-ubiquitinated proteins. Dimerization is
required for the binding of poly-ubiquitin, but not for the binding of mono-ubiquitin. Interacts with EGFR
(phosphorylated)
Miscellaneous: This protein has one functional calcium-binding site (By similarity)
Sequence caution: Sequence=BAE45748.1; Type=Erroneous termination; Positions=904; Note=Translated as Arg;
Sequence=CAH56175.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Selected PDB 3D structures from and Proteopedia for CBLB (see all 11):
2AK5 (3D)        2BZ8 (3D)        2DO6 (3D)        2J6F (3D)        2JNH (3D)        2LDR (3D)    
Secondary accessions: A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5
Alternative splicing: 3 isoforms:  Q13191-1   Q13191-2   Q13191-3   

Explore the universe of human proteins at neXtProt for CBLB: NX_Q13191

Explore proteomics data for CBLB at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine and serine residues upon TCR or BCR activation, and upon various types of cell
    stimulation1
  • Auto-ubiquitinated upon EGF-mediated cell activation or upon T-cell costimulation by CD28; which promotes
    proteasomal degradation1
  • Ubiquitination2 at Lys97, Lys516
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CBLB (Q13191) (see all 17)
     PLQIPHL  LPDTYQHLR  QAPARPPKP  LKNSPPYILD 


    See CBLB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_733762.2  
    ENSEMBL proteins: 
     ENSP00000377598   ENSP00000264122   ENSP00000384170   ENSP00000384816   ENSP00000384938  
     ENSP00000409750   ENSP00000400949   ENSP00000393906   ENSP00000377595   ENSP00000446116  
    Reactome Protein details: Q13191

    CBLB Human Recombinant Protein Products:

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    Novus Biologicals CBLB Proteins
    Novus Biologicals CBLB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CBLB 

     
    antibodies-online proteins for CBLB (4 products) 

     
    antibodies-online peptides for CBLB

    CBLB Antibody Products:

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    Abcam antibodies for CBLB
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    antibodies-online antibodies for CBLB (42 products) 

    CBLB Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CBLB 
    antibodies-online kits for CBLB (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 12):
     IPR001841 Znf_RING
     IPR011992 EF-hand-dom_pair
     IPR014742 Adaptor_Cbl_SH2-like
     IPR024162 Adaptor_Cbl
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q13191

    ProtoNet protein and cluster: Q13191

    4 Blocks protein domains:
    IPB000449 Ubiquitin-associated domain
    IPB000980 SH2 domain signature
    IPB001841 Zn-finger
    IPB003153 Adaptor protein Cbl


    UniProtKB/Swiss-Prot: CBLB_HUMAN, Q13191
    Domain: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the
    RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of
    three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain
    Domain: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme
    Domain: The UBA domain interacts with poly-ubiquitinated proteins
    Similarity: Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 UBA domain


    Find genes that share domains with CBLB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBLB_HUMAN, Q13191
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and
    transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR
    (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal
    transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement
    for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination,
    which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1
    activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating
    SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR
    ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3

         Genatlas biochemistry entry for CBLB:
    protein (109kDa),homolog to the proto-oncogene v-cbl,expressed in a variety of normal tissues,potentially
    interacting with signal transduction molecules,regulating in mouse,the CD28 dependence of T cell activation and
    putatively contributing to autoimmune diseases

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001784phosphotyrosine binding IEA--
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0004871signal transducer activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI12177062
         
    Find genes that share ontologies with CBLB           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CBLB:
     Increased cilium length after  

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cblb):
     cardiovascular system  growth/size/body  hematopoietic system  immune system  integument 
     liver/biliary system  mortality/aging 

    Find genes that share phenotypes with CBLB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CBLB: Cblbtm1Hua Cblbtm1Pngr

       genOway: Develop your customized and physiologically relevant rodent model for CBLB

    miRNA
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    Block miRNA regulation of human, mouse, rat CBLB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CBLB (see all 23):
    hsa-miR-30c hsa-miR-181c hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-30d hsa-miR-944 hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmidCBLB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CBLB
    Predesigned siRNA for gene silencing in human, mouse, rat CBLB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CBLB

    Clone
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    OriGene clones in human, mouse for CBLB (see all 7)
    OriGene ORF clones in mouse, rat for CBLB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CBLB (NM_170662)
    Sino Biological Human cDNA Clone for CBLB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBLB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBLB
    Addgene plasmids for CBLB 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CBLB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CBLB_HUMAN, Q13191: Cytoplasm. Note=Upon EGF stimulation, associates with endocytic vesicles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    plasma membrane4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with CBLB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CBLB About   (see all 25)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2B cell receptor signaling pathway (KEGG)
    T cell receptor signaling pathway0.38
    TCR Signaling Pathway0.36
    3Downstream Signaling Events Of B Cell Receptor (BCR)
    Signaling by the B Cell Receptor (BCR)0.79
    4ErbB signaling pathway
    ErbB signaling pathway0.52
    5Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
    Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.47


    Find genes that share SuperPaths with CBLB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for CBLB
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors
    Protein Stability

    Selected BioSystems Pathways for CBLB (see all 10)
        EGFR1 Signaling Pathway
    Insulin Signaling
    Kit Receptor Signaling Pathway
    TCR Signaling Pathway
    IL-7 Signaling Pathway


    2 Reactome Pathways for CBLB
        Antigen processing: Ubiquitination & Proteasome degradation
    Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


    Selected Kegg Pathways  (Kegg details for CBLB) (see all 11):
        ErbB signaling pathway
    Ubiquitin mediated proteolysis
    Endocytosis
    Jak-STAT signaling pathway
    T cell receptor signaling pathway

    UniProtKB/Swiss-Prot: CBLB_HUMAN, Q13191
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CBLB: 

              EGF / PDGF Signaling Pathway in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CBLB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CBLB (Q131911, 2, 3 ENSP000002641224) via UniProtKB, MINT, STRING, and/or I2D (see all 170)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3KBP1Q96B971, 2, 3, ENSP000003809214EBI-744027,EBI-346595 MINT-6170285 MINT-60962 MINT-6170307 MINT-6170329 MINT-7218592 MINT-7218365 MINT-7218322 MINT-7218288 MINT-6170347 MINT-7218378 MINT-6170377 MINT-60960 MINT-60961 MINT-7218305 I2D: score=3 STRING: ENSP00000380921
    CD2APQ9Y5K61, 2, 3, ENSP000003522644EBI-744027,EBI-298152 MINT-7041409 MINT-7041451 MINT-7041464 MINT-7041365 I2D: score=1 STRING: ENSP00000352264
    GRB2P629931, 2, 3, ENSP000003390074EBI-744027,EBI-401755 MINT-8256558 MINT-61549 I2D: score=7 STRING: ENSP00000339007
    ASAP1Q9ULH11, 2, 3, ENSP000003502974EBI-744027,EBI-346622 MINT-4299894 MINT-4299879 I2D: score=1 STRING: ENSP00000350297
    ARHGEF7Q141552, 3, ENSP000003648934MINT-56632 MINT-56631 MINT-56630 I2D: score=3 STRING: ENSP00000364893
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002669positive regulation of T cell anergy IEA--
    GO:0006607NLS-bearing protein import into nucleus TAS7784085
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS7784085
    GO:0007166cell surface receptor signaling pathway IEA--

    Find genes that share ontologies with CBLB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CBLB

    5 HMDB Compounds for CBLB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    5 Novoseek inferred chemical compound relationships for CBLB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 55.9 22 10022120 (5), 14604964 (2), 16503409 (2), 11375397 (1) (see all 12)
    phosphatidylinositol 36.9 4 11087752 (2), 18227156 (1), 12842890 (1)
    proline 26.5 1 10362357 (1)
    leucine 22 1 10362357 (1)
    lipid 0 4 14604964 (2), 18164258 (2)



    Find genes that share compounds with CBLB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CBLB gene: 
    NM_170662.3  

    Unigene Cluster for CBLB:

    Cbl proto-oncogene, E3 ubiquitin protein ligase B
    Hs.430589  [show with all ESTs]
    Unigene Representative Sequence: BX537484
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394030 ENST00000264122(uc003dwc.3 uc011bhi.2) ENST00000476370
    ENST00000407712(uc003dwa.3) ENST00000403724(uc003dwe.2) ENST00000405772(uc003dwd.2)
    ENST00000438603 ENST00000447441 ENST00000443752 ENST00000394027 ENST00000545639(uc011bhj.1)

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    Selected qRT-PCR Assays for microRNAs that regulate CBLB (see all 23):
    hsa-miR-30c hsa-miR-181c hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-30d hsa-miR-944 hsa-miR-223
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CBLB (NM_170662)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBLB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBLB
    Addgene plasmids for CBLB 
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      QuantiTect SYBR Green Assays in human, mouse, rat CBLB
      QuantiFast Probe-based Assays in human, mouse, rat CBLB

    Additional mRNA sequence: 

    AB075490.1 AK094184.1 AK123147.1 AK130668.1 AK292792.1 AK302533.1 AK302892.1 AK316276.1 
    BC032851.2 BC065915.1 BX537484.1 BX649066.1 CR749655.1 DQ349203.1 DQ349204.1 U26710.1 
    U26711.1 U26712.1 

    12 DOTS entries:

    DT.444439  DT.92053067  DT.434061  DT.100772721  DT.91719515  DT.101982100  DT.95162760  DT.100705648 
    DT.100778492  DT.120927257  DT.40131732  DT.100756329 

    Selected AceView cDNA sequences (see all 160):

    AA262777 AA251289 BG939368 AA251219 BM931334 BM723140 BQ222488 AK094184 
    BE043961 BX115572 BM931260 AA862717 AA330838 U26712 AI221219 CR622009 
    AW780214 BG235963 BQ007649 AA788833 AA699786 CA417348 CK300211 AI014374 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CBLB (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a ·
    SP1:                                                              -                                                                                         -   
    SP2:                                                              -                                                                                         -   
    SP3:                                                              -                                                                                         -   
    SP4:                                            -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                       -   
    SP5:                                                                                                                                                        -   

    ExUns: 18b ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22
    SP1:              -           -               
    SP2:                                          
    SP3:                                          
    SP4:              -           -               
    SP5:        -     -           -               


    ECgene alternative splicing isoforms for CBLB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CBLB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTGCCCAG
    CBLB Expression
    About this image


    CBLB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Brain (Nervous System)
             Cerebral Cortex
    CBLB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CBLB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.430589

    UniProtKB/Swiss-Prot: CBLB_HUMAN, Q13191
    Tissue specificity: Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain
    and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal
    muscle. Present in lymphocytes (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CBLB: 
              EGF / PDGF Signaling Pathway in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for CBLB gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cblb1 , 5 Casitas B-lineage lymphoma b1, 5 87.62(n)1
    94.88(a)1
      16 (32.88 cM)5
    2086501  NM_001033238.11  NP_001028410.11 
     520315495 
    chicken
    (Gallus gallus)
    Aves CBLB1 Cbl proto-oncogene, E3 ubiquitin protein ligase B 79.87(n)
    87.04(a)
      418406  XM_416621.4  XP_416621.3 
    lizard
    (Anolis carolinensis)
    Reptilia CBLB6
    Cbl proto-oncogene B, E3 ubiquitin protein ligase
    83(a)
    1 ↔ 1
    3(170645491-170775331)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cblb1 Cbl proto-oncogene B, E3 ubiquitin protein ligase 73.77(n)
    78.9(a)
      448509  NM_001006801.1  NP_001006802.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cblb1 Cas-Br-M (murine) ecotropic retroviral transforming more 65.17(n)
    70.6(a)
      556277  XM_001921926.4  XP_001921961.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cbl3 dorsal/ventral axis determination,
    follicular more
    72(a)   3 66C12   --
    worm
    (Caenorhabditis elegans)
    Secernentea sli-13 adaptor-like E3 ubiquitin ligase 56(a)   X(756037-761201)   --


    ENSEMBL Gene Tree for CBLB (if available)
    TreeFam Gene Tree for CBLB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CBLB gene
    CBLC2  CBL2  
    3 SIMAP similar genes for CBLB using alignment to 7 protein entries:     CBLB_HUMAN (see all proteins):
    DKFZp779A0729    CBLC    CBL

    Find genes that share paralogs with CBLB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CBLB (see all 4229)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1417659371,2
    Cuntested1105421265(+) GCTGGG/AAGTGG 2 /L syn11Minor allele frequency- A:0.00NA 4550
    rs1820009991,2
    --105376721(+) TGCAAC/TGAAGA 1 -- ds50010--------
    rs1850397851,2
    --105376831(+) AGGTAC/TGTTAT 1 -- ds50010--------
    rs1506919861,2
    C--105376918(+) CAGGCA/GTAAGT 1 -- ds50010--------
    rs64376091,2
    C,H--105376942(+) GTTATT/ATAACT 1 -- ds500116Minor allele frequency- A:0.00NS EA NA WA CSA 666
    rs96579101,2
    C,F,H--105376995(-) AGCTAC/TTACAG 1 -- ds500117Minor allele frequency- T:0.04NS EA NA 1698
    rs1882403151,2
    --105377180(+) TTTTCA/CCATCT 1 -- ut310--------
    rs1810557571,2
    --105377181(+) TTTCCC/GATCTC 1 -- ut310--------
    rs1399366011,2
    --105377191(+) CTCAAC/TAGTGA 1 -- ut310--------
    rs353124271,2
    C--105377237(+) CATAC-/TTTTTT 1 -- ut311Minor allele frequency- T:0.00NA 2

    HapMap Linkage Disequilibrium report for CBLB (105374305 - 105588396 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CBLB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv877309CNV Loss21882294
    nsv877310CNV Loss21882294
    nsv829651CNV Loss17160897
    nsv877311CNV Loss21882294
    nsv877312CNV Loss21882294
    nsv508234CNV Loss20534489
    dgv5228n71CNV Loss21882294
    nsv525071CNV Gain19592680
    nsv511097CNV Complex20534489

    Human Gene Mutation Database (HGMD): CBLB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CBLB
    DNA2.0 Custom Variant and Variant Library Synthesis for CBLB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 604491    OMIM disorders: --

    1 disease for CBLB:    
    About MalaCards
    cannabis dependence


    Find genes that share disorders with CBLB           About GenesLikeMe

    4 Novoseek inferred disease relationships for CBLB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmunity 47.5 10 17391982 (2), 18565657 (1), 19801520 (1), 20395198 (1) (see all 6)
    lymphoma 34.7 4 11591765 (1), 18227156 (1), 17391982 (1), 20038312 (1)
    tumors 0 2 17403934 (2)
    cancer 0 4 17403934 (2), 17391982 (1), 20395198 (1)

    Genetic Association Database (GAD): CBLB
    Human Genome Epidemiology (HuGE) Navigator: CBLB (7 documents)

    Export disorders for CBLB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CBLB gene, integrated from 10 sources (see all 140):
    (articles sorted by number of sources associating them with CBLB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene. (PubMed id 7784085)1, 2, 3, 9 Keane M.M....Lipkowitz S. (Oncogene 1995)
    2. cbl-b inhibits epidermal growth factor receptor signaling. (PubMed id 10086340)1, 2, 9 Ettenberg S.A.... Lipkowitz S. (Oncogene 1999)
    3. Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. (PubMed id 10022120)1, 2, 9 Elly C....Liu Y.-C. (Oncogene 1999)
    4. Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b. (PubMed id 15273720)1, 2, 9 Davies G.C.... Lipkowitz S. (Oncogene 2004)
    5. Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells. (PubMed id 11087752)1, 2, 9 Fang D.... Liu Y.-C. (J. Biol. Chem. 2001)
    6. CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. (PubMed id 12177062)1, 2, 9 Szymkiewicz I....Dikic I. (J. Biol. Chem. 2002)
    7. Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex. (PubMed id 11375397)1, 2, 9 Ettenberg S.A.... Lipkowitz S. (J. Biol. Chem. 2001)
    8. CBLB variants in type 1 diabetes and their genetic interaction with CTLA4. (PubMed id 15629882)1, 4, 9 Bergholdt R....Pociot F. (J. Leukoc. Biol. 2005)
    9. Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells. (PubMed id 11526404)1, 2, 9 Fang D. and Liu Y.-C. (Nat. Immunol. 2001)
    10. Cbl promotes clustering of endocytic adaptor proteins. (PubMed id 16228008)1, 2, 9 Jozic D.... Bravo J. (Nat. Struct. Mol. Biol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 868 HGNC: 1542 AceView: CBLB Ensembl:ENSG00000114423 euGenes: HUgn868
    ECgene: CBLB Kegg: 868 H-InvDB: CBLB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CBLB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CBLB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CBLB gene:
    Search GeneIP for patents involving CBLB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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