CBLB Gene
protein-coding GIFtS : 67 GCID: GC03 M105374
Cbl proto-oncogene, E3 ubiquitin protein ligase B Cas-Br-M (murine) ectropic retroviral transforming sequence...
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Aliasesfor CBLB gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Cbl Proto-Oncogene, E3 Ubiquitin Protein Ligase B 1 2 Signal Transduction Protein CBL-B2 3 RNF561 2 3 RING Finger Protein 562 3 Cbl-B1 SH3-Binding Protein CBL-B2 3 Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B1 2 E3 Ubiquitin-Protein Ligase CBL-B2 Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence B1 2 EC 6.3.2.-3 Casitas B-Lineage Lymphoma Proto-Oncogene B2 3 EC 6.3.28
Export aliases for CBLB gene to outside databases Previous GC identifers: GC03M102013 GC03M104895 GC03M106658 GC03M106698 GC03M106859 GC03M102751
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Summariesfor CBLB gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: CBLB_HUMAN, Q13191 Function : E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, andtransfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization Gene Wiki entry for CBLB
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Genomic Viewsfor CBLB gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_005612.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CBLB gene promoter:TBP Pax-6 RelA NF-kappaB E4BP4 S8 deltaCREB TFIID STAT3 NF-kappaB1 Other transcription factors Search SABiosciences Chromatin IP Primers for CBLB Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3q13.11 Ensembl cytogenetic band: 3q13.11 HGNC cytogenetic band: 3q CBLB Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M105374: view genomic region
(about GC identifiers )
Start: 105,374,305 bp from pter End:
105,588,396 bp from pter
Size: 214,092 bases Orientation:
minus strand
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Proteinsfor CBLB gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CBLB_HUMAN, Q13191 See
protein sequence )Recommended Name: Size : 982 amino acids; 109450 DaSubunit : Interacts with SH3 domain-containing proteins LCK, CRK and SORBS1. Interacts with LCP2 and ZAP70. May interactwith CBL (By similarity). Interacts with SH3 domain-containing proteins VAV1, FYN, FGR, PLCG1, GRB2, CRKL, PIK3R1 and SH3KBP1/CIN85. Identified in heterotrimeric complexes with SH3KBP1/CIN85, CD2AP and ARHGEF7, where one CBLB peptide binds two copies of the other protein. Interacts with poly-ubiquitinated proteins. Dimerization is required for the binding of poly-ubiquitin, but not for the binding of mono-ubiquitin
Subcellular location : Cytoplasm. Note=Upon EGF stimulation, associates with endocytic vesiclesMiscellaneous : This protein has one functional calcium-binding site (By similarity)Sequence caution : Sequence=BAE45748.1; Type=Erroneous termination; Positions=904; Note=Translated as Arg;Sequence=CAH56175.1; Type=Erroneous initiation;
6/10 PDB 3D structures from (see all 10 ):2AK5 (3D) 2BZ8 (3D) 2DO6 (3D) 2J6F (3D) 2JNH (3D) 2LDR (3D) Secondary accessions : A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5Alternative splicing : 4 isoforms : Q13191-1 Q13191-2 Q13191-3 Q13191-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CBLB: NX_Q13191 Post-translational modifications:
Phosphorylated on tyrosine and serine residues upon TCR or BCR activation, and upon various types of cell stimulation1 Auto-ubiquitinated upon EGF-mediated cell activation or upon T-cell costimulation by CD28; which promotes proteasomal degradation1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q13191 4/17 DME Specific Peptides for CBLB (Q13191 ) (see all 17 )CBLB Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_733762.2 ENSEMBL proteins: ENSP00000377598 ENSP00000264122 ENSP00000384170 ENSP00000384816 ENSP00000384938 ENSP00000409750 ENSP00000400949 ENSP00000393906 ENSP00000377595 ENSP00000446116 Reactome Protein details: Q13191 Human Recombinant Protein Products: Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing CBLB Antibody Products: Assay Products for CBLB:
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Protein
Domains /for CBLB gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/12 InterPro domains/families (see all 12 ):
Graphical View of Domain Structure for InterPro Entry Q13191 ProtoNet protein and cluster: Q13191
4 Blocks protein families : IPB000449 IPB000980 IPB001841 IPB003153 UniProtKB/Swiss-Prot: CBLB_HUMAN, Q13191 Domain : The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-typezinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain Domain : The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzymeDomain : The UBA domain interacts with poly-ubiquitinated proteinsSimilarity : Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domainSimilarity : Contains 1 RING-type zinc fingerSimilarity : Contains 1 UBA domain
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Functionfor CBLB gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: CBLB_HUMAN, Q13191 Function : E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, andtransfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization
Genatlas biochemistry entry for CBLB protein (109kDa),homolog to the proto-oncogene v-cbl,expressed in a variety of normal tissues,potentially interacting with signal transduction molecules,regulating in mouse,the CD28 dependence of T cell activation and putatively contributing to autoimmune diseases Enzyme Numbers (IUBMB): EC 6.3.2.- 1 EC 6.3.2 2 Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CBLB (NM_170662 ) Sino Biological Human cDNA Clone for CBLB DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CBLB Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CBLB
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLB
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing 1 GenomeRNAi human phenotype for CBLB :Animal Models: Cblb tm1Hua Cblb tm1Pngr 8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cblb) :About GeneDecksing
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Pathways & Interactionsfor CBLB gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/25 super-pathways (see all 25 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Antigen processing: Ubiquitination & Proteasome degradation 2 Immune System 3 Assembly of Signalosomes at the Activated BCR 4 B cell receptor signaling pathway 5 Tyrosine Kinases / Adaptors
Pathway sources See GeneCards unified pathways Show all pathways 3 5/10 (see all 10 ) 5/8 (see all 8 )5/10 (Kegg details for CBLB) (see all 10 ):UniProtKB/Swiss-Prot: CBLB_HUMAN, Q13191 Pathway : Protein modification; protein ubiquitinationAbout GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CBLB STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/160 Interacting proteins for CBLB (Q13191 1 , 2 , 3 ENSP00000264122 4 via UniProtKB, MINT, STRING , and/or I2D (see all 160 )
Interactant Interaction Details GeneCard External ID(s) SH3KBP1 Q96B97 2 , 3 ENSP00000380921 4 MINT-6170285 MINT-60962 MINT-6170307 MINT-6170329 MINT-7218592 MINT-7218365 MINT-7218322 MINT-7218288 MINT-6170347 MINT-7218378 MINT-6170377 MINT-60960 MINT-60961 MINT-7218305 I2D:
score=3 STRING: ENSP00000380921 GRB2 P62993 1 , 2 , 3 ENSP00000339007 4 EBI-744027,EBI-401755 MINT-8256558 MINT-61549 I2D:
score=7 STRING: ENSP00000339007 CD2AP Q9Y5K6 2 , 3 ENSP00000352264 4 MINT-7041409 MINT-7041451 MINT-7041464 MINT-7041365 I2D:
score=1 STRING: ENSP00000352264 ARHGEF7 Q14155 2 , 3 ENSP00000364893 4 MINT-56632 MINT-56631 MINT-56630 I2D:
score=3 STRING: ENSP00000364893 CRKL P46109 2 , 3 ENSP00000346300 4 MINT-8028115 MINT-8030520 I2D:
score=5 STRING: ENSP00000346300
About this table Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14 ): About this table
About GeneDecksing
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Drugs & Compoundsfor CBLB gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for CBLB 5 HMDB Compounds for CBLB About this table 5 Novoseek chemical compound relationships for CBLB gene About this table CBLB
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Transcriptsfor CBLB gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CBLB gene: NM_170662.3 Unigene Cluster for CBLB:
Cbl proto-oncogene, E3 ubiquitin protein ligase B Hs.430589 [show with all ESTs ] Unigene Representative Sequence: BX537484 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000394030 ENST00000264122 (uc003dwc.3 uc011bhi.2 ) ENST00000476370 ENST00000407712 (uc003dwa.3 ) ENST00000403724 (uc003dwe.2 ) ENST00000405772 (uc003dwd.2 )ENST00000438603 ENST00000447441 ENST00000443752 ENST00000394027 ENST00000545639 (uc011bhj.1 )Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CBLB (NM_170662 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CBLB Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CBLB
Additional cDNA sequence: AB075490.1 AK094184.1 AK123147.1 AK130668.1 AK292792.1 AK302533.1 AK302892.1 AK316276.1 BC032851.2 BC065915.1 BX537484.1 BX649066.1 CR749655.1 DQ349203.1 DQ349204.1 U26710.1 U26711.1 U26712.1
12 DOTS entries : DT.444439 DT.92053067
DT.434061 DT.100772721 DT.91719515 DT.101982100 DT.95162760 DT.100705648 DT.100778492 DT.120927257 DT.40131732 DT.100756329 24/160 AceView cDNA sequences (see all 160 ):
AA862717 AA788833 AA262777 AA251219 BX115572 AW338641 AK094184 AW780214 AA883076 AI221219 CA417348 BF448140 AI499586 AI094520 BM931334 CA868238 U26712 BQ188745 AV701750 BM931260 AI923831 BF514278 BG939368 CA428612 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CBLB (see all 10 ) About this scheme ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · SP1 : - - SP2 : - - SP3 : - - SP4 : - - - - - - - - - - - - - - - - SP5 : -
ExUns: 18b ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 SP1 : - - SP2 : SP3 : SP4 : - - SP5 : - - -
ECgene alternative splicing isoforms for CBLB
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Expression for CBLB gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CBLB expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CCTTGCCCAG
About this image CBLB expression in embryonic tissues and stem cells About this table 2 LifeMap In Vivo Development Anatomical Compartments/CellsTissue Category (developmental path) Ovary Antral Follicle Cumulus Cells Ovary Brain Cerebral Cortex Brain Expression: Experimental details:
In-situ hybridization
See CBLB Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CBLB SOURCE GeneReport for Unigene cluster: Hs.430589 UniProtKB/Swiss-Prot: CBLB_HUMAN, Q13191 Tissue specificity : Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain andliver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle. Present in lymphocytes (at protein level) SABiosciences Expression via Pathway-Focused PCR Arrays including CBLB : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLB
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Orthologsfor CBLB gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for CBLB gene from 5/17 species (see all 17 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves CBLB1
Cas-Br-M (murine) ecotropic retroviral transforming more
79.82(n) 87.4(a)
418406 XM_416621.3 XP_416621.2
lizard Reptilia CBLB6
--
83(a)
1 ↔ 1
3(170648193-170771168)
zebrafish Actinopterygii cblb1
Cas-Br-M (murine) ecotropic retroviral transforming more
65.66(n) 71.08(a)
556277 XM_001921926.3 XP_001921961.3
fruit fly Insecta Cbl3
dorsal/ventral axis determination,more
72(a)
3 66C12 --
worm Secernentea sli-13
adaptor-like E3 ubiquitin ligase
56(a)
X(756037-761201) --
ENSEMBL Gene Tree for CBLB (if available)TreeFam Gene Tree for CBLB (if available)
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Paralogsfor CBLB gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CBLB gene CBLC 2 CBL 2 3 SIMAP similar genes for CBLB using alignment to 7 protein entries: CBLB_HUMAN (see all proteins ):DKFZp779A0729 CBLC CBL About GeneDecksing
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Genomic Variantsfor CBLB gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 3 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for CBLB (105374305 - 105588396 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for CBLB 1 CNV 91460 Human Gene Mutation Database (HGMD) : CBLB SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor CBLB gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 604491
OMIM disorders : --20/22 (see all 22 ): About MalaCards juvenile myelomonocytic leukemia myelomonocytic leukemia systemic lupus erythematosus myeloid leukemia lupus erythematosus chronic myeloid leukemia acute myeloid leukemia myeloid malignancy cblc graves' disease multiple sclerosis hepatitis c leprosy leukemia hepatitis b measles hepatocellular carcinoma hepatitis neuroblastoma carcinoma 4 Novoseek disease relationships for CBLB gene About this table
Genetic Association Database (GAD): CBLB Human Genome Epidemiology (HuGE) Navigator: CBLB (7 documents) Export disorders for CBLB gene to outside databases
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Publicationsfor CBLB gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CBLB gene, integrated from 9 sources (see all 130 ):(articles sorted by number of sources associating them with CBLB) Utopia : connect your pdf to the dynamic
Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene. (PubMed id 7784085) 1 , 2 , 3, 9(1995) cbl-b inhibits epidermal growth factor receptor signaling. (PubMed id 10086340) 1 , 2 , 9(1999) Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. (PubMed id 10022120) 1 , 2 , 9(1999) Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b. (PubMed id 15273720) 1 , 2 , 9(2004) Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells. (PubMed id 11087752) 1 , 2 , 9(2001) CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. (PubMed id 12177062) 1 , 2 , 9(2002) Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex. (PubMed id 11375397) 1 , 2 , 9(2001) CBLB variants in type 1 diabetes and their genetic interaction with CTLA4. (PubMed id 15629882) 1 , 4, 9(2005) Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells. (PubMed id 11526404) 1 , 2 , 9(2001) Cbl promotes clustering of endocytic adaptor proteins. (PubMed id 16228008) 1 , 2 , 9(2005)
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External Searches for CBLB gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CBLB gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing CBLB gene
(According to HUGE )
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Specialized Databases showing CBLB gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for CBLB gene: CBLB GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CBLB gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CBLB OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for CBLB Browse OriGene Fluorogenic Cell Assay Kits Browse OriGene siRNAs OriGene 3'-UTR Clone for CBLB OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for CBLB OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CBLB OriGene Custom Protein Services for CBLB OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CBLB QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for CBLB (Cbl-b)
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBLB
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CBLB
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and Proteopedia 
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Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
