Aliases for CBLB Gene
- Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 2 3
- Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B 2 3
- Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence B 2 3
- Casitas B-Lineage Lymphoma Proto-Oncogene B 3 4
- Signal Transduction Protein CBL-B 3 4
- SH3-Binding Protein CBL-B 3 4
- RING Finger Protein 56 3 4
External Ids for CBLB Gene
Previous GeneCards Identifiers for CBLB Gene
GeneCards Summary for CBLB Gene
CBLB (Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Immune System and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include calcium ion binding and ubiquitin-protein transferase activity. An important paralog of this gene is CBLC.
UniProtKB/Swiss-Prot for CBLB Gene
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.