Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CBL Gene

protein-coding   GIFtS: 70
GCID: GC11P119110

Cbl Proto-Oncogene, E3 Ubiquitin Protein Ligase

(Previous name: Cas-Br-M (murine) ecotropic retroviral transforming sequence)
(Previous symbol: CBL2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cbl Proto-Oncogene, E3 Ubiquitin Protein Ligase1 2     RING Finger Protein 552 3
CBL21 2 3 5     C-CBL2
Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence1 2     FRA11B2
Oncogene CBL21 2     NSLL2
Casitas B-Lineage Lymphoma Proto-Oncogene2 3     E3 Ubiquitin-Protein Ligase CBL2
Proto-Oncogene C-Cbl2 3     Fragile Site, Folic Acid Type, Rare, Fra(11)(Q23.3)2
Signal Transduction Protein CBL2 3     EC 6.3.2.-3
RNF552 3     EC 6.3.28

External Ids:    HGNC: 15411   Entrez Gene: 8672   Ensembl: ENSG000001103957   OMIM: 1653605   UniProtKB: P226813   

Export aliases for CBL gene to outside databases

Previous GC identifers: GC11M121124 GC11P120588 GC11P118614 GC11P118582 GC11P115017


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CBL Gene:
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the
enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer
of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an
N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated
substrates and target them for proteasome degradation. As such it functions as a negative regulator of many
signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including
acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. (provided by
RefSeq, Mar 2012)

GeneCards Summary for CBL Gene: 
CBL (Cbl proto-oncogene, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with CBL include noonan syndrome-like disorder, and noonan-like syndrome disorder with or without juvenile myelomonocytic leukemia, and among its related super-pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Development EGFR signaling pathway. GO annotations related to this gene include ubiquitin-protein ligase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CBLC.

UniProtKB/Swiss-Prot: CBL_HUMAN, P22681
Function: Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by
activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from
specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the
proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB,
EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the SRC
family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic
cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for
osteoclastic bone resorption. The Tyr-731 phosphorylated form induces the activation and recruitment of
phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast
function

Gene Wiki entry for CBL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CBL gene promoter:
         Elk-1   AP-1   ATF-2   STAT1beta   STAT5A   STAT1alpha   PPAR-gamma1   STAT3   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCBL promoter sequence
   Search SABiosciences Chromatin IP Primers for CBL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

CBL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBL gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P119110:  view genomic region     (about GC identifiers)

Start:
119,076,752 bp from pter      End:
119,178,859 bp from pter
Size:
102,108 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CBL_HUMAN, P22681 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase CBL  
Size: 906 amino acids; 99633 Da
Subunit: Interacts (phosphorylated at Tyr-731) with PIK3R1. Associates with NCK via its SH3 domain. The
phosphorylated C-terminus interacts with CD2AP via its second SH3 domain. Binds to UBE2L3. Interacts with
adapters SLA, SLA2 and with the phosphorylated C-terminus of SH2B2. Interacts with EGFR, SYK and ZAP70 via the
highly conserved Cbl-N region. Also interacts with SORBS1 and INPPL1/SHIP2. Interacts with phosphorylated LAT2.
May interact with CBLB (By similarity). Interacts with ALK, AXL, BLK, FGR and FGFR2. Interacts with CSF1R, EPHB1,
FLT1, KDR, PDGFRA and PDGFRB; regulates receptor degradation through ubiquitination. Interacts with HCK and LYN.
Interacts with TEK/TIE2 (tyrosine phosphorylated)
Subcellular location: Cytoplasm. Cell membrane. Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane
Miscellaneous: This protein has one functional calcium-binding site
6/20 PDB 3D structures from and Proteopedia for CBL (see all 20):
1B47 (3D)        1FBV (3D)        1YVH (3D)        2CBL (3D)        2JUJ (3D)        2K4D (3D)    
Secondary accessions: A3KMP8

Explore the universe of human proteins at neXtProt for CBL: NX_P22681

Explore proteomics data for CBL at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine residues by ALK, EGFR, SYK, FYN and ZAP70 (By similarity). Phosphorylated on tyrosine
    residues in response to FLT1 and KIT signaling. Phosphorylated on tyrosine residues by INSR and FGR.
    Phosphorylated on several tyrosine residues by constitutively activated FGFR3. Not phosphorylated at Tyr-731 by
    FGFR3. Phosphorylated on tyrosine residues by activated CSF1R, PDGFRA and PDGFRB. Phosphorylated on tyrosine
    residues by HCK
  • UniProtKB: Ubiquitinated, leading to its degradation via the proteasome
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22681

  • 4/9 DME Specific Peptides for CBL (P22681) (see all 9)
     LPDTYQHLR  LKNSPPYILD  NPDLTGLCEPTP  LFKEGKERMYEE 

    CBL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CBL Protein Expression
    REFSEQ proteins: NP_005179.2  
    ENSEMBL proteins: 
     ENSP00000264033  
    Reactome Protein details: P22681
    Human Recombinant Protein Products for CBL: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CBL
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for CBL 
    OriGene Custom Protein Services for CBL
    GenScript Custom Purified and Recombinant Proteins Services for CBL
    Novus Biologicals CBL Proteins
    Novus Biologicals CBL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0016600colocalizes with flotillin complex ISS--

    CBL for ontologies           About GeneDecksing



    CBL Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CBL
    R&D Systems Antibodies for CBL
    Cell Signaling Technology (CST) Antibodies for CBL 
    OriGene Antibodies for CBL
    OriGene Custom Antibody Services for CBL
    GenScript Superior Antibodies for CBL
    Novus Biologicals CBL Antibodies
    Abcam antibodies for CBL
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for CBL
    LSBio Antibodies in human, mouse, rat for CBL 

    Assay Products for CBL: 
    EMD Millipore Kits and Assays for the Analysis of CBL
    OriGene Custom Assay Services for CBL
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CBL
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5/14 InterPro protein domains (see all 14):
     IPR001841 Znf_RING
     IPR011992 EF-hand-like_dom
     IPR014742 Adaptor_Cbl_SH2-like
     IPR024162 Adaptor_Cbl
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry P22681

    ProtoNet protein and cluster: P22681

    3 Blocks protein domains:
    IPB000449 Ubiquitin-associated domain
    IPB001841 Zn-finger
    IPB003153 Adaptor protein Cbl


    UniProtKB/Swiss-Prot: CBL_HUMAN, P22681
    Domain: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme
    Domain: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the
    RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of
    three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain
    Similarity: Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 UBA domain


    CBL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBL_HUMAN, P22681
    Function: Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by
    activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from
    specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the
    proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB,
    EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the SRC
    family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic
    cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for
    osteoclastic bone resorption. The Tyr-731 phosphorylated form induces the activation and recruitment of
    phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast
    function

         Genatlas biochemistry entry for CBL:
    Cas-Br-M (murine) ecotropic retroviral transforming sequence,including a CGG trinucleotide repeat,abundantly
    expressed in thymus,acting as a RING-type E2-dependent ubiquitin protein ligase,binding and stimulating the
    ubiquitination of PDGFRs,EGFR,CSF1R,also interacting with signal transduction molecules,key mediator of HCK
    (hematopoietic cell kinase) induced signaling in hematopoietic cells

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001784phosphotyrosine binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS2030914
    GO:0004842ubiquitin-protein ligase activity TAS15465819
    GO:0004871signal transducer activity IEA--
    GO:0005509calcium ion binding IEA--
         
    CBL for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CBL:
     Metaphase cells  Synthetic lethal with Ras 

         15/20 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Cbl) (see all 20):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

    CBL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CBL: Cbltm1Soga Cbltm1Ddlb Cbltm1.1Hua

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CBL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CBL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CBL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CBL 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CBL
    8/176 QIAGEN miScript miRNA Assays for microRNAs that regulate CBL (see all 176):
    hsa-miR-26a-2* hsa-miR-520f hsa-miR-605 hsa-miR-502-3p hsa-miR-200b hsa-miR-642b hsa-miR-4326 hsa-miR-3909
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CBL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CBL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CBL
    Sirion Biotech Customized adenovirus for overexpression of CBL

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CBL (see all 7)
    OriGene ORF clones in mouse, rat for CBL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CBL (NM_005188)
    Sino Biological Human cDNA Clone for CBL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBL
    Sirion Biotech Customized lentivirus for stable overexpression of CBL 
                         Customized lentivirus expression plasmids for stable overexpression of CBL 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CBL
    Search LifeMap BioReagents cell lines for CBL
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CBL About   (see all 72)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    IL-7 Signaling Pathway0.40
    Adipocytokines & Insulin Signaling0.34
    Development Thrombopoietin-regulated cell processes0.38
    2Development EGFR signaling pathway
    Development EGFR signaling pathway0.87
    EGF Pathway0.41
    Development ERBB-family signaling0.57
    3Development HGF signaling pathway
    Development EGFR signaling via small GTPases0.44
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.31
    Development EGFR signaling via PIP30.40
    4BAFF in B-Cell Signaling
    RANK Signaling in Osteoclasts0.45
    RANKL/RANK Signaling Pathway0.31
    RANK Pathway0.38
    5Immune response IFN gamma signaling pathway
    Immune response IFN gamma signaling pathway0.43
    IFN-gamma pathway0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/16 EMD Millipore Pathways for CBL (see all 16)
        Chemotaxis CXCR4 signaling pathway
    Immune response CD16 signaling in NK cells
    Development EGFR signaling via PIP3
    Translation Regulation activity of EIF2
    Common schema of ubiquitination

    1 R&D Systems Pathway for CBL
        Adipocytokines & Insulin Signaling

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CBL (see all 14)
        FLT3 Signaling
    Internalin Pathway
    Molecular Mechanisms of Cancer
    Ephrin-Eph Signaling
    Rap1 Pathway

    3 Cell Signaling Technology (CST) Pathways for CBL
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors
    Protein Stability

    5/15 GeneGo (Thomson Reuters) Pathways for CBL (see all 15)
        Development EPO-induced MAPK pathway
    Development EGFR signaling pathway
    Development Thrombopoietin-regulated cell processes
    Development EGFR signaling via small GTPases
    Translation Regulation of EIF2 activity

    5/34 BioSystems Pathways for CBL (see all 34)
        EGFR1 Signaling Pathway
    Insulin Signaling
    Signaling Pathways in Glioblastoma
    IL-5 Signaling Pathway
    IL-4 signaling Pathway


    5/21        Reactome Pathways for CBL (see all 21)
        Regulation of signaling by CBL
    Signaling by EGFR in Cancer
    Disease
    EGFR downregulation
    Negative regulation of FGFR signaling


    5/10         Kegg Pathways  (Kegg details for CBL) (see all 10):
        ErbB signaling pathway
    Ubiquitin mediated proteolysis
    Endocytosis
    Jak-STAT signaling pathway
    T cell receptor signaling pathway

    UniProtKB/Swiss-Prot: CBL_HUMAN, P22681
    Pathway: Protein modification; protein ubiquitination


    CBL for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CBL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/385 Interacting proteins for CBL (P226811, 2, 3 ENSP000002640334) via UniProtKB, MINT, STRING, and/or I2D (see all 385)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    EGFRP005331, 2, 3, ENSP000002754934EBI-518228,EBI-297353 MINT-6170185 MINT-16158 MINT-6539293 MINT-6539009 MINT-6539329 MINT-61493 MINT-6539305 MINT-6538916 MINT-6539317 MINT-6539560 MINT-6539574 MINT-6170566 MINT-60973 MINT-7046383 MINT-6539341 MINT-60972 I2D: score=9 STRING: ENSP00000275493
    GRB2P629931, 2, 3, ENSP000003390074EBI-518228,EBI-401755 MINT-65972 MINT-60974 MINT-6169721 MINT-60977 MINT-7040249 MINT-65979 MINT-6539462 MINT-65973 I2D: score=10 STRING: ENSP00000339007
    SPRY2O435972, 3, ENSP000003663064MINT-6539050 MINT-6539113 MINT-6170575 MINT-6539098 MINT-6539601 MINT-6538989 MINT-6538901 MINT-6169721 MINT-6539083 MINT-6170624 MINT-6539143 MINT-6539038 MINT-8030771 MINT-6539128 MINT-6169688 MINT-6170593 MINT-6539063 I2D: score=4 STRING: ENSP00000366306
    METP085812, 3, ENSP000003172724MINT-14027 MINT-16046 MINT-6538928 MINT-6539019 MINT-6539423 MINT-6539387 MINT-6539363 MINT-6539411 MINT-6539399 MINT-6539587 MINT-6539435 MINT-6539375 I2D: score=4 STRING: ENSP00000317272
    YWHAQP273482, 3, ENSP000002380814MINT-8006676 MINT-8005073 MINT-7899812 MINT-8005953 MINT-8005087 MINT-8005023 MINT-8005960 MINT-8005080 MINT-8005974 MINT-8005094 MINT-8005885 MINT-8005967 I2D: score=4 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent TAS2030914
    GO:0007166cell surface receptor signaling pathway TAS15465819
    GO:0007173epidermal growth factor receptor signaling pathway TAS15465819
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0014068positive regulation of phosphatidylinositol 3-kinase cascade IMP17003487

    CBL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CBL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CBL

    5 HMDB Compounds for CBL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    10/38 Novoseek inferred chemical compound relationships for CBL gene (see all 38)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 85 520 9210408 (8), 8920860 (7), 10204582 (6), 9535867 (6) (see all 99)
    phosphatidylinositol 66.9 71 15581361 (6), 14640702 (5), 7791764 (4), 8612729 (3) (see all 31)
    phosphotyrosine 65.3 18 8995358 (2), 9988765 (2), 10490604 (2), 15465819 (1) (see all 11)
    piceatannol 61.3 1 12435267 (1)
    thiosemicarbazide 49.9 3 8900205 (1), 10779765 (1), 8626543 (1)
    convulxin 46.5 1 9153205 (1)
    geldanamycin 46.2 2 12574167 (1)
    ag 1478 43.6 1 19947936 (1)
    lactacystin 39.9 1 12829707 (1)
    phosphoinositide 36.2 7 11042121 (2), 10940298 (1), 14530346 (1), 9794375 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about CBL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CBL gene: 
    NM_005188.3  

    Unigene Cluster for CBL:

    Cbl proto-oncogene, E3 ubiquitin protein ligase
    Hs.504096  [show with all ESTs]
    Unigene Representative Sequence: NM_005188
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000264033(uc001pwe.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CBL
    8/176 QIAGEN miScript miRNA Assays for microRNAs that regulate CBL (see all 176):
    hsa-miR-26a-2* hsa-miR-520f hsa-miR-605 hsa-miR-502-3p hsa-miR-200b hsa-miR-642b hsa-miR-4326 hsa-miR-3909
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CBL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CBL
    Clone
    Products:
         
    OriGene clones in human, mouse for CBL (see all 7)
    OriGene ORF clones in mouse, rat for CBL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CBL (NM_005188)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBL
    Sirion Biotech Customized lentivirus for stable overexpression of CBL 
                         Customized lentivirus expression plasmids for stable overexpression of CBL 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CBL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CBL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBL

    Additional mRNA sequence: 

    AK092300.1 AL832396.1 BC132733.1 BC136463.1 BX648139.1 X57110.1 X69207.1 

    5 DOTS entries:

    DT.453210  DT.120727695  DT.210757  DT.103199  DT.95368792 

    18 AceView cDNA sequences:

    BE550582 X69207 NM_005188 AW015807 AL110451 AI633902 BX106739 AL712494 
    AA972853 X57110 AI808688 AI206156 AI963960 BG722940 BF801902 AW935681 
    BF752017 BF894352 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CBL expression in normal human tissues (normalized intensities)      CBL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTAAAAA
    CBL Expression
    About this image


    CBL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             cd14+ cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             lymph node ; non-germinal center cells   
     
     Spleen (Hematopoietic System)    fully expand to see all 2 entries
             spleen ; cells in white pulp   
     
     Limb (Muscoskeletal System)
             Limb Bud Mesenchyme Cells Limb Bud

    See CBL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CBL

    SOURCE GeneReport for Unigene cluster: Hs.504096
        SABiosciences Expression via Pathway-Focused PCR Arrays including CBL: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CBL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CBL
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBL
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CBL gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cbl1 , 5 Casitas B-lineage lymphoma1, 5 88.67(n)1
    93.69(a)1
      9 (24.72 cM)5
    124021  NM_007619.21  NP_031645.21 
     441492625 
    chicken
    (Gallus gallus)
    Aves CBL1 Cas-Br-M (murine) ecotropic retroviral transforming more 77.83(n)
    86.04(a)
      374038  NM_204208.1  NP_989539.1 
    lizard
    (Anolis carolinensis)
    Reptilia CBL6
    Uncharacterized protein
    82(a)
    1 ↔ 1
    GL343797.1(168280-199197)
    African clawed frog
    (Xenopus laevis)
    Amphibia Cbl2 Cbl proto-oncogene protein 76.21(n)    AF237765.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cbl1 Cas-Br-M (murine) ecotropic retroviral transforming more 68.45(n)
    74.43(a)
      492364  NM_001007330.1  NP_001007331.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cbl1 , 3 dorsal/ventral axis determination,
    follicular more3
    CG7037-PA1
    71(a)3
    53.29(n)1
    50.82(a)1
      3 66C123
    389611  NM_139967.11  NP_648224.11 
    worm
    (Caenorhabditis elegans)
    Secernentea sli-11 , 3 adaptor-like E3 ubiquitin ligase3
    Protein SLI-11
    54(a)3
    55.19(n)1
    51.21(a)1
      X(756037-761201)3
    1804191  NM_001029627.11  NP_001024798.11 


    ENSEMBL Gene Tree for CBL (if available)
    TreeFam Gene Tree for CBL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CBL gene
    CBLC2  CBLB2  
    3 SIMAP similar genes for CBL using alignment to 2 protein entries:     CBL_HUMAN (see all proteins):
    CBLC    CBLB    TRIM39

    CBL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2081 SNPs in CBL are shown (see all 2081)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0643344
    Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia (NSLL)4--see VAR_0643342 D Y mis40--------
    VAR_0643324
    Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia (NSLL)4--see VAR_0643322 Q P mis40--------
    VAR_0643354
    Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia (NSLL)4--see VAR_0643352 R Q mis40--------
    VAR_0643334
    Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia (NSLL)4--see VAR_0643332 K E mis40--------
    rs2676067081,2
    Cpathogenic1119013936(+) CTGCCA/GATGTG 2 Q R mis10--------
    rs3776666581,2
    C--115024113(+) CGTCT-/CCAAAA 1 -- int10--------
    rs1127129911,2
    C--115030472(+) GTCTC-/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1129177071,2
    F--115030783(+) TTTTTT/GTTTTT 1 -- int12Minor allele frequency- G:0.22CSA WA 119
    rs116018211,2
    C,H--115056290(+) TTTTTT/GTTTTT 1 -- int1 trp31Minor allele frequency- G:0.25NA 4
    rs113137491,2
    C,F--115063869(+) TGGGAG/-GGCTG 1 -- int14Minor allele frequency- -:0.50NA CSA 8

    HapMap Linkage Disequilibrium report for CBL (119076752 - 119178859 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CBL:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2665710CNV Deletion23128226
    esv1143209CNV Insertion17803354
    esv2519793CNV Insertion19546169
    nsv525043CNV Loss19592680
    nsv898417CNV Loss21882294
    nsv898418CNV Loss21882294
    nsv528636CNV Gain19592680


    Human Gene Mutation Database (HGMD): CBL
    5/12 SABiosciences Cancer Mutation PCR Assays for CBL (see all 12):
    Cosmic IdAA Change
    34066p.C384Y
    34052p.Y371H
    34077p.R420Q
    34057p.C384R
    41789p.C416Y
    5 SABiosciences Cancer Mutation PCR Arrays containing CBL:
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Cancer Comprehensive Panel 384HT
    Oncogene Panel 384HT
    Myelodysplastic Syndromes
    Tumor Suppressor Panel 384HT
    SeqTarget long-range PCR primers for resequencing CBL
    DNA2.0 Custom Variant and Variant Library Synthesis for CBL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 165360   
    OMIM disorders: 613563  
    UniProtKB/Swiss-Prot: CBL_HUMAN, P22681
  • Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia (NSLL) [MIM:613563]: A
    syndrome characterized by a phenotype reminiscent of Noonan syndrome. Clinical features are highly variable,
    including facial dysmorphism, short neck, developmental delay, hyperextensible joints and thorax abnormalities
    with widely spaced nipples. The facial features consist of triangular face with hypertelorism, large low-set
    ears, ptosis, and flat nasal bridge. Some patients manifest cardiac defects. Some have an increased risk for
    certain malignancies, particularly juvenile myelomonocytic leukemia. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 20/51 diseases for CBL (see all 51):    About MalaCards
    noonan syndrome-like disorder    noonan-like syndrome disorder with or without juvenile myelomonocytic leukemia    jacobsen syndrome    thanatophoric dysplasia
    pernicious anemia    saethre-chotzen syndrome    noonan syndrome    juvenile myelomonocytic leukemia
    hiv-1, resistance to    methylmalonic acidemia    hepatitis e    megaloblastic anemia
    filariasis    systemic mastocytosis    chronic myelomonocytic leukemia    homocystinuria
    wiskott-aldrich syndrome    mastocytosis    cblc    myeloid leukemia

    5 diseases from the University of Copenhagen DISEASES database for CBL:
    Vitamin B12 deficiency     Methylmalonic acidemia     Pernicious anemia     Lymphoma
    Leukemia

    CBL for disorders           About GeneDecksing

    10/16 Novoseek inferred disease relationships for CBL gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 38.7 2 7545163 (1), 19734451 (1)
    myeloid leukemia chronic 29.5 3 9845379 (1), 12764153 (1), 18235045 (1)
    lymphoma 27 10 17704644 (1), 14530346 (1), 16289966 (1), 17391982 (1) (see all 8)
    wiskott-aldrich syndrome 17.9 2 8810341 (1), 10427990 (1)
    leukemia 17.5 5 7545163 (1), 9845379 (1), 18974118 (1), 11684286 (1) (see all 5)
    leukemia t-cell 12.8 1 2030914 (1)
    acute leukemia 12.3 1 12764153 (1)
    cancer 5.23 6 10891544 (2), 18632619 (1), 16227975 (1), 19901108 (1)
    metastasis 5.03 3 14991403 (3)
    necrosis 3.42 2 15562428 (1)

    Genetic Association Database (GAD): CBL
    Human Genome Epidemiology (HuGE) Navigator: CBL (18 documents)

    Export disorders for CBL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CBL gene, integrated from 9 sources (see all 743):
    (articles sorted by number of sources associating them with CBL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases. (PubMed id 9535867)1, 2, 9 Deckert M.... Liu Y.C. (1998)
    2. Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils. (PubMed id 12435267)1, 2, 9 Melander F....Dib K. (2003)
    3. APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. (PubMed id 11997497)1, 2, 9 Liu J.... Saltiel A.R. (2002)
    4. APS, an adaptor protein containing pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl. (PubMed id 10374881)1, 2, 9 Wakioka T....Yoshimura A. (1999)
    5. APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis. (PubMed id 9989826)1, 2, 9 Yokouchi M.... Yoshimura A. (1999)
    6. Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway. (PubMed id 18034775)1, 2, 9 Fasen K....Huynh-Do U. (2008)
    7. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2- dependent ubiquitin-protein ligase. (PubMed id 10514377)1, 2, 9 Joazeiro C.A....Liu Y.-C. (1999)
    8. Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. (PubMed id 18235045)1, 2, 9 Wu J....Donato N.J. (2008)
    9. Binding of Cbl to a phospholipase Cgamma1-docking sit e on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation. (PubMed id 17620338)1, 2, 9 Reddi A.L....Band H. (2007)
    10. Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl. (PubMed id 15556646)1, 2, 9 Grossmann A.H....Druker B.J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 867 HGNC: 1541 AceView: CBL Ensembl:ENSG00000110395 euGenes: HUgn867
    ECgene: CBL Kegg: 867 H-InvDB: CBL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CBL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CBL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CBL gene:
    Search GeneIP for patents involving CBL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Kits and Assays for the Analysis of CBL
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CBL
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CBL (CBL)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CBL   OriGene RNAi products in human, mouse, rat for CBL  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for CBL   OriGene clones in human, mouse for CBL  
     OriGene qSTAR qPCR primer pairs in human, mouse for CBL   OriGene Purified Protein for CBL  
     OriGene ORF clones in mouse, rat for CBL   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CBL   OriGene Custom Protein Services for CBL  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CBL
     QIAGEN SeqTarget long-range PCR primers for resequencing CBL
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBL
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CBL
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBL
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBL
     GenScript Custom Purified and Recombinant Proteins Services for CBL GenScript cDNA clones with any tag delivered in your preferred vector for CBL
     GenScript Custom Assay Services for CBL GenScript Superior Antibodies for CBL
     GenScript Custom overexpressing Cell Line Services for CBL CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for CBL 

     Regulatory tfbs in CBL promoter
     Search Chromatin IP Primers for CBL
     RT2 qPCR Primer Assay in human, mouse, rat CBL
     GNC Network for CBL
     SABiosciences PCR Arrays including human, mouse, rat CBL
     Search Tocris compounds for CBL
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CBL
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CBL antibodies
     CBL proteins
     CBL lysates
     Antibodies for CBL
     See all of Abcam's Antibodies, Kits and Proteins for CBL
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CBL
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBL
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CBL
     SwitchGear Promoter luciferase reporter plasmids for CBL
     ThermoFisher Antibody for CBL
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBL
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CBL
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CBL
    Customized:
     lentivirus for stable overexpression of CBL
     lentivirus expression plasmids for stable overexpression of CBL
     adenovirus for overexpression of CBL
     LSBio Antibodies in human, mouse, rat for CBL
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CBL gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4