Aliases for CBFB Gene
Aliases for CBFB Gene
External Ids for CBFB Gene
- HGNC: 1539
- Entrez Gene: 865
- Ensembl: ENSG00000067955
- OMIM: 121360
- UniProtKB: Q13951
Previous GeneCards Identifiers for CBFB Gene
- GC16P057757
- GC16P067440
- GC16P066798
- GC16P066839
- GC16P065620
- GC16P052937
Summaries for CBFB Gene
-
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
-
CBFB has been shown to be mutated in estrogen receptor positive breast cancer, although the significance of many of these mutations is yet to be determined. The CBFB-MYH11 fusion is a commonly accepted marker of favorable prognosis in acute myeloid leukemia.
GeneCards Summary for CBFB Gene
CBFB (Core-Binding Factor Beta Subunit) is a Protein Coding gene. Diseases associated with CBFB include Acute Myeloid Leukemia With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16;16)(P13;Q22) and Leukemia, Acute Myeloid. Among its related pathways are ATF-2 transcription factor network and Dual hijack model of Vif in HIV infection. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity.
UniProtKB/Swiss-Prot for CBFB Gene
-
CBF binds to the core site, 5-PYGPYGGT-3, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBFB enhances DNA binding by RUNX1.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBFB Gene
Genomics for CBFB Gene
Regulatory Elements for CBFB Gene
Enhancers for CBFB Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CBFB on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CBFB gene promoter:
Regulatory Element Products
Genomic Location for CBFB Gene
- Chromosome:
- 16
- Start:
- 67,029,116 bp from pter
- End:
- 67,101,058 bp from pter
- Size:
- 71,943 bases
- Orientation:
- Plus strand
Genomic View for CBFB Gene
Genes around CBFB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q22.1 by Ensembl
- 16q22.1 by Entrez Gene
- 16q22.1 by HGNC
CBFB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBFB Gene
Proteins for CBFB Gene
-
Protein details for CBFB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13951-PEBB_HUMAN
- Recommended name:
- Core-binding factor subunit beta
- Protein Accession:
- Q13951
- A8K347
- Q13124
- Q9HCT2
Protein attributes for CBFB Gene
- Size:
- 182 amino acids
- Molecular mass:
- 21508 Da
- Quaternary structure:
-
- Heterodimer with RUNX1. Interacts with COPRS (By similarity). Found in a complex with PRMT5, RUNX1 and CBFB (By similarity).
Three dimensional structures from OCA and Proteopedia for CBFB Gene
Protein Expression for CBFB Gene
Post-translational modifications for CBFB Gene
Other Protein References for CBFB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CBFB (CBFB)
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-
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-
Cloud-Clone Corp. Antibodies for CBFB
- Invitrogen Antibodies for CBFB
- antibodies-online Antibodies for CBFB: See all 91
- GeneTex CBFB antibody for CBFB
-
Santa Cruz Biotechnology (SCBT) Antibodies for CBFB
Protein Products
-
OriGene Purified Proteins for CBFB
- Search Origene for MassSpec and Protein Over-expression Lysates for CBFB
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-
Cloud-Clone Corp. Proteins for CBFB
- antibodies-online Proteins for CBFB: See all 15
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CBFB
Assay Products
- antibodies-online Kits for CBFB: See all 1
No data available for DME Specific Peptides for CBFB Gene
Domains & Families for CBFB Gene
Protein Domains for CBFB Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CBFB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13951- Family:
-
- Belongs to the CBF-beta family.
No data available for Gene Families for CBFB Gene
Function for CBFB Gene
Molecular function for CBFB Gene
- GENATLAS Biochemistry:
- core binding factor to the enhancer of T cell receptor genes,beta subunit,altered in acute myeloid leukemia (AML-M4Eo) with inversion inv(16)(p13;q22) or t(16;16)(p13;q22) translocation
- UniProtKB/Swiss-Prot Function:
- CBF binds to the core site, 5-PYGPYGGT-3, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBFB enhances DNA binding by RUNX1.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | TAS | 8351518 |
| GO:0003713 | transcription coactivator activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 2845103 |
Phenotypes for CBFB Gene
- MGI mutant phenotypes for CBFB:
-
inferred from 16 alleles
- mortality/aging
- cellular phenotype
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- integument phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- embryo phenotype
- hematopoietic system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for CBFB:
Animal Models for CBFB Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for CBFB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBFB gene
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CRISPR Products
-
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Santa Cruz Biotechnology (SCBT) CRISPR for CBFB
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miRNA for CBFB Gene
- miRTarBase miRNAs that target CBFB
-
- hsa-mir-145-5p (MIRT000676)
- hsa-mir-155-5p (MIRT001562)
- hsa-mir-125b-5p (MIRT003970)
- hsa-let-7b-5p (MIRT005054)
- hsa-mir-30a-5p (MIRT005217)
- hsa-mir-130b-3p (MIRT020330)
- hsa-mir-615-3p (MIRT039772)
- hsa-mir-92a-3p (MIRT049318)
- hsa-mir-5692a (MIRT075065)
- hsa-mir-100-3p (MIRT195380)
- hsa-mir-153-3p (MIRT195381)
- hsa-mir-570-5p (MIRT195382)
- hsa-mir-624-3p (MIRT195383)
- hsa-mir-4327 (MIRT195384)
- hsa-mir-548ag (MIRT195385)
- hsa-mir-548ai (MIRT195386)
- hsa-mir-548ba (MIRT195387)
- hsa-mir-448 (MIRT558945)
- hsa-mir-365b-3p (MIRT558946)
- hsa-mir-365a-3p (MIRT558947)
- hsa-mir-5582-3p (MIRT558948)
- hsa-mir-548x-3p (MIRT558949)
- hsa-mir-548j-3p (MIRT558950)
- hsa-mir-548aq-3p (MIRT558951)
- hsa-mir-548am-3p (MIRT558952)
- hsa-mir-548aj-3p (MIRT558953)
- hsa-mir-548ah-3p (MIRT558954)
- hsa-mir-548ae-3p (MIRT558955)
miRNA Products
- Search ViGene Biosciences for CBFB
Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CBFB
-
ViGene Biosciences adenoviral particle packaged cDNA for CBFB gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CBFB gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBFB Gene
Localization for CBFB Gene
Subcellular locations from UniProtKB/Swiss-Prot for CBFB Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0016020 | membrane | IDA | 19946888 |
Pathways & Interactions for CBFB Gene
Pathways by source for CBFB Gene
3 BioSystems pathways for CBFB Gene
Interacting Proteins for CBFB Gene
Selected Interacting proteins:
Q13951-PEBB_HUMAN
ENSP00000415151
for CBFB Gene via
IID
STRING
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | IMP | 22190036 |
| GO:0001503 | ossification | IEA | -- |
| GO:0001649 | osteoblast differentiation | IEA | -- |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | 8351518 |
| GO:0030098 | lymphocyte differentiation | IEA | -- |
No data available for SIGNOR curated interactions for CBFB Gene
Transcripts for CBFB Gene
mRNA/cDNA for CBFB Gene
- (6) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (30) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CBFB Gene
CRISPR Products
-
OriGene CRISPR knockouts for CBFB
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBFB
- GenScript: Design CRISPR guide RNA sequences for CBFB
miRNA Products
- Search ViGene Biosciences for CBFB
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBFB
- Browse OriGene Inhibitory RNA Products For CBFB
-
ViGene Biosciences ready-to-package AAV shRNAs for CBFB gene
Clone Products
- Sino Biological Human cDNA Clone for CBFB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CBFB
- VectorBuilder custom plasmid, inducible vectors for CBFB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBFB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||
| SP3: | |||||||||||||||||||||||
| SP4: |
Expression for CBFB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Immature Endochondral Osteoblasts Vertebrae
- Immature Endochondral Osteoblasts Stylopod Periosteum
- Endochondral Preosteoblasts Stylopod Perichondrium
- Hypertrophic Chondrocytes Stylopod Growth Plate
- Endochondral Preosteoblasts Zeugopod Perichondrium
-
Cartilage (Muscoskeletal System)
- Hypertrophic Chondrocytes Stylopod Growth Plate
- Prehypertrophic Chondrocytes Vertebrae
- Hypertrophic Chondrocytes Zeugopod Growth Plate
- Prehypertrophic Chondrocytes Rib
- Hypertrophic Chondrocytes Autopod Growth Plate
-
Brain (Nervous System)
- Adult Dopaminergic Neurons Ventral Tegmental Area
- Striatum
- Medulla Oblongata
- Cerebral Cortex
- Neural Tube (Nervous System)
-
Neurons
- Adult Dopaminergic Neurons Ventral Tegmental Area
- Lung (Respiratory System)
- Kidney (Urinary System)
This gene is overexpressed in Peripheral blood mononuclear cells (11.4), Tlymphocyte (9.1), Cervix (6.9), and CD8 Tcells (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CBFB Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CBFB Gene:
CBFBSOURCE GeneReport for Unigene cluster for CBFB Gene:
Hs.460988Evidence on tissue expression from TISSUES for CBFB Gene
- Nervous system(4.2)
- Eye(4.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CBFB Gene
Germ Layers:
- mesoderm
Systems:
- immune
- lymphatic
Organs:
General:
- blood
- bone marrow
- white blood cell
Primer Products
-
OriGene qPCR primer pairs and template standards for CBFB
-
OriGene qPCR primer pairs for CBFB
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CBFB Gene
Orthologs for CBFB Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| oppossum (Monodelphis domestica) |
Mammalia | CBFB 35 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | CBFB 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CBFB 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CBFB 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Cbfb 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cbfb 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | CBFB 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CBFB 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cbfb 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6721 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cbfb 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000317 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Bgb 36 34 35 |
|
||
| Bro 35 |
|
OneToMany | |||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.1961 34 |
|
- Species where no ortholog for CBFB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CBFB Gene
No data available for Paralogs for CBFB Gene
Variants for CBFB Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036226 | A breast cancer sample | ||||
| rs1000097241 | -- | 67,055,029(+) | TGTTT(A/G)TCGGG | intron-variant | |
| rs1000107266 | -- | 67,096,785(+) | CTGGC(C/T)AACAC | intron-variant | |
| rs1000149531 | -- | 67,054,839(+) | GCTCC(A/G)CCTCC | intron-variant | |
| rs1000215572 | -- | 67,070,857(+) | TCTCA(A/G)AAACA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv526e214 | CNV | gain | 21293372 |
| esv2677554 | CNV | deletion | 23128226 |
| esv3638876 | CNV | loss | 21293372 |
| esv3638877 | CNV | loss | 21293372 |
| esv988966 | CNV | insertion | 20482838 |
| nsv1056738 | CNV | loss | 25217958 |
| nsv1143825 | CNV | deletion | 24896259 |
| nsv1840 | CNV | insertion | 18451855 |
| nsv473276 | CNV | novel sequence insertion | 20440878 |
| nsv509626 | CNV | insertion | 20534489 |
| nsv509627 | CNV | insertion | 20534489 |
| nsv516064 | CNV | gain | 19592680 |
Residual Variation Intolerance Score:
46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.43;
9.40% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CBFB Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBFB Gene
Disorders for CBFB Gene
(7) MalaCards diseases for CBFB Gene - From: OMIM, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) |
|
|
| leukemia, acute myeloid |
|
|
| cleidocranial dysplasia |
|
|
| myeloid leukemia |
|
|
| core binding factor acute myeloid leukemia |
|
|
Search CBFB in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PEBB_HUMAN- Note=A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11. {ECO:0000269 PubMed:8351518}.
Relevant External Links for CBFB
No data available for Genatlas for CBFB Gene
Publications for CBFB Gene
- Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta. (PMID: 10856244) Warren A.J. … Rabbitts T.H. (EMBO J. 2000) 3 4 22 64
- Structure of the leukemia-associated human CBFB gene. (PMID: 7607682) Hajra A. … Collins F.S. (Genomics 1995) 4 22 46 64
- Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. (PMID: 8351518) Liu P. … Collins F.S. (Science 1993) 2 3 4 64
- The core binding factor CBF negatively regulates skeletal muscle terminal differentiation. (PMID: 20195544) Philipot O. … Ait-Si-Ali S. (PLoS ONE 2010) 3 22 64
- The cleidocranial dysplasia-related R131G mutation in the Runt-related transcription factor RUNX2 disrupts binding to DNA but not CBF-beta. (PMID: 20225274) Han M.S. … Choi J.Y. (J. Cell. Biochem. 2010) 3 22 64
Products for CBFB Gene
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- antibodies-online Antibodies for CBFB: See all 91
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- ViGene Biosciences adenoviral particle packaged cDNA for CBFB gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for CBFB
- VectorBuilder custom plasmid, inducible vectors for CBFB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBFB
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CBFB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer