V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

CBFB Gene

protein-coding GIFtS: 65

GC16P065620

core-binding factor, beta subunit
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CBF-beta ^³
PEA2-beta ^³
PEBP2-beta ^³
PEBP2B ^¹, ²

Descriptions
Polyomavirus enhancer-binding protein 2 beta subunit ^³
SL3-3 enhancer factor 1 beta subunit ^²
SL3-3 enhancer factor 1 subunit beta ^³
SL3/AKV core-binding factor beta subunit ^², ³
core-binding factor, beta subunit ^²
polyomavirus enhancer binding protein 2, beta subunit ^²

External Ids
HGNC: 1539¹
Entrez Gene: 865²
UniProtKB: Q13951³
Ensembl: ENSG00000067955⁷

Search outside databases for aliases for CBFB gene

Previous GC identifers: GC16P057757 GC16P067440 GC16P066798 GC16P066839

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CBFB:

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription

factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of

genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is

a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as

the complex binds to the core site of various enhancers and promoters, including murine leukemia

virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing

generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a

pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting

of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the

smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute

myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have

been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: PEBB_HUMAN, Q13951

Function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters,

including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and

GM-CSF promoters. CBFB enhances DNA binding by RUNX1

Gene Wiki entry for CBFB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CBFB gene

Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1

CBFB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P065620: (about GC identifiers)

Start:	65,620,551 bp from pter
End:	65,692,462 bp from pter
Size:	71,912 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000016.8 NT_010498.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PEBB_HUMAN, Q13951 (See protein sequence)

Recommended Name: Core-binding factor subunit beta

Size: 182 amino acids; 21508 Da

Subunit: Heterodimer with RUNX1

Subcellular location: Nucleus (Potential)

PDB structures from and Proteopedia :

1CL3 (3D)

1E50 (3D)

1H9D (3D)

Secondary accessions: Q13124 Q9HCT2

Alternative splicing: 2 isoforms: Q13951-1 Q13951-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001746.1 NP_074036.1

ENSEMBL proteins:

ENSP00000290858

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CBFb)
	Human Recombinant Proteins from Abnova (CBFB)

OriGene Purified Recombinant Human Proteins (see all 2): CBFB

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

About this table

Antibodies for CBFB:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CBFB
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (CBFb), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CBFB)
	Novus Biologicals Antibodies for CBFB

Assays for CBFB:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13951

ProtoNet protein and cluster: Q13951

1 Blocks protein family: IPB003417 Core binding factor

UniProtKB/Swiss-Prot: PEBB_HUMAN, Q13951

Similarity: Belongs to the CBF-beta family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CBFB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CBFB)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001755

Applied Biosystems Silencer® siRNAs for CBFB

Sigma-Aldrich siRNA for CBFB

Sigma-Aldrich shRNA for CBFB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001755
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001755
untagged cDNA clones in CMV expression vector (see all 2): NM_001755

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_022845

UniProtKB/Swiss-Prot: PEBB_HUMAN, Q13951

Function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters,

including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and

GM-CSF promoters. CBFB enhances DNA binding by RUNX1

Genatlas biochemistry entry for CBFB:

core binding factor to the enhancer of T cell receptor genes,beta subunit,altered in acute myeloid

leukemia (AML-M4Eo) with inversion inv(16)(p13;q22) or t(16;16)(p13;q22) translocation

15/18 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Cbfb) (see all 18 ):

	cellular	craniofacial	digestive/alimentary	embryogenesis
growth/size	hematopoietic system	homeostasis/metabolism	immune system	lethality-prenatal/perinatal
limbs/digits/tail	liver/biliary system	nervous system	no phenotypic analysis	respiratory system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	8351518 9751756
GO:0003702	RNA polymerase II transcription factor activity	TAS	8351518
GO:0003713	transcription coactivator activity	IEA	--
GO:0005515	protein binding	IPI	10856244 12217689

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for CBFB

5/13 Interacting proteins for CBFB (ENSP00000290858³ Q13951²) via UniProtKB, MINT, and/or STRING (see all 13 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RUNX1	Q01196²	STRING (score=.999) MINT-4791117
RUNX3	ENSP00000343477³	STRING (score=.995)
RUNX2	ENSP00000352514³	STRING (score=.982)
MYH11	ENSP00000300036³	STRING (score=.955)
IGHA1	ENSP00000374989³	STRING (score=.928)

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001649	osteoblast differentiation	IEA	--
GO:0030098	lymphocyte differentiation	IEA	--
GO:0030099	myeloid cell differentiation	IEA	--
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0048469	cell maturation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CBFB

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CBFB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CBFB)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001755

Sigma-Aldrich siRNA for CBFB

Sigma-Aldrich shRNA for CBFB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001755 NM_022845

REFSEQ mRNAs for CBFB gene (2 alternative transcripts):

NM_001755.2 NM_022845.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001755 NM_022845

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001755
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001755
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001755

Additional cDNA sequence:

AF294326.1 AK290462.1 AK291834.1 AK311084.1 AK311724.1 BC018509.1 BT006862.1 CR594690.1

CR608601.1 CR611500.1 CR614949.1 CR618498.1 L20298.1 X87833.1

11 DOTS entries:

DT.91696141 DT.97854197 DT.100694704 DT.100781415 DT.95199052 DT.95219068 DT.91658411 DT.40244814

DT.95199095 DT.97795389 DT.414896

24/30 AceView cDNA sequences (see all 30 ):

CR618498 BU858589 W74323 R74019 BI962672 BU541927 NM_022845 BI789190

AL561208 BX372258 BX328185 CB159140 CK821239 AW955066 BG029644 BQ954600

AA358402 AI766036 BI035784 BI035782 BG698954 N24456 CD696664 BX436408

highest scoring ESTs for CBFB:

L20298 AA336594 AA352073 AA361743 AA371340 AI766036 AL121151 AL561208 AU118397 AU119080

Unigene Cluster for CBFB:

Core-binding factor, beta subunit

Hs.460988 [show with all ESTs]

Unigene Representative Sequence: NM_001755

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CBFB

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	·	8c
SP1:					-												-
SP2:					-										-		-
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for CBFB

1 Ensembl transcript including schematic representation:

ENST00000290858

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CBFB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CBFB

¹ / ² / ³

5 probe-sets matching CBFB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41175_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L20298	1.00	1.00	1.00	1
202370_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001755	0.60	1.00	0.82	1
206788_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF294326	0.60	1.00	0.82	1
202370_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206788_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGCCCTTTTT

SOURCE GeneReport for Unigene cluster: Hs.460988
Expression variation in blood from EXPOLDB for CBFB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CBFB gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CBFB¹	--	core-binding factor, beta subunit	97.75(n) 100(a)	479690 XM_536821.2 XP_536821.2
cow (Bos taurus)	CBFB¹	--	core-binding factor, beta subunit	96.97(n) 98.93(a)	614678 XM_866255.2 XP_871348.2
rat (Rattus norvegicus)	Cbfb¹	--	core-binding factor, beta subunit	92.35(n) 97.06(a)	361391 NM_001013191.1 NP_001013209.1
mouse (Mus musculus)	Cbfb^{1, 5}	8 (51.00 cM)⁵	core binding factor beta^{1, 5}	93.4(n)¹ 97.86(a)¹	12400¹ NM_022309.3¹ NP_071704.2¹ AI893578⁵ AK089094⁵ (see all 20)
chicken (Gallus gallus)	CBFB¹	--	core-binding factor, beta subunit	88.24(n) 95.88(a)	395257 NM_204570.2 NP_989901.2

About this table Species with no ortholog for CBFB

ENSEMBL Gene Tree for CBFB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/241 NCBI SNPs in CBFB are shown (see all 241 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 51)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6499112^1,2	A,C,F,H	65692855(+)	`CACATG/AATAAA`	2	--	ng3¹		11	EU EA WA NA	980
	rs7185895^1,2	A,C,F,H	65618555(+)	`ACGACG/CAGTGT`	2	--	ng5¹		4	EU EA WA	416
	rs16957169^1,2	F,H	65690677(+)	`AGTCTA/GTAGCA`	2	--	ut3¹ ese³		7	NA EU EA WA	544
	rs9927827^1,2	F,H	65691603(+)	`AAATGG/ACATTA`	2	--	ut3¹		4	EU EA WA	382
	rs11641437^1,2	H	65690690(+)	`TTAAAA/CCTGCT`	2	--	ut3¹ ese³		4	EU EA WA	420
	rs8047502^1,2	A,C,F,H	65680284(+)	`GGTTAA/TGATTA`	2	--	int¹		4	EU EA WA	418
	rs8050312^1,2	A,C,F,H	65668549(+)	`accaaC/Tataag`	2	--	int¹		7	EU EA WA NA	556
	rs6499111^1,2	A,C,F,H	65681427(+)	`CAAGCC/TATTTT`	2	--	int¹		8	EU EA NA	622
	rs2031005^1,2	A,C,F,H	65662650(+)	`gctctC/Tatgaa`	2	--	int¹		7	EU EA WA NA	560
--	rs11866893^1,2	A,C,F,H	65676760(+)	`gtagaC/Gacgag`	2	--	int¹		3	EA WA	298

About this table

HapMap Linkage Disequilibrium images for CBFB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 121360

UniProtKB/Swiss-Prot: PEBB_HUMAN, Q13951

A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO

subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that

consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11

10/14 Novoseek disease relationships for CBFB gene (see all 14 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia myelomonocytic acute	87.18	1	15381374 (1)
leukemogenesis	78.66	2	11105900 (1)
cleidocranial dysplasia	72.07	2	10856244 (1)
leukemia	63.36	10	11920209 (1), 17961830 (1), 9606182 (1), 12217689 (1) (see all 9)
eosinophilia	55.83	3	17452259 (1), 8779782 (1)
chromosomal aberrations	45.29	2	16390316 (1), 8779782 (1)
acute leukemia	41.57	3	19202074 (1), 10856244 (1)
myelodysplastic syndromes	38.65	3	11986246 (2)
myeloid leukemia chronic	28.54	2	16213359 (1)
lymphoblastic leukemia acute	27.10	2	16213359 (1)

About this table

Human Gene Mutation Database: CBFB
Genetic Association Database: CBFB

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/137 PubMed articles for CBFB gene (see all 137 ):

Structure of the leukemia-associated human CBFB gene. (PubMed id 7607682)^{1, 3, 4, 6} Hajra A. and Collins F.S. (1995)
Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. (PubMed id 8351518)^{2, 3, 4} Liu P.... Collins F.S. (1993)
Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta. (PubMed id 10856244)^{1, 3, 4} Warren A.J.... Rabbitts T.H. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The leukemia-associated AML1 (Runx1) -- CBF beta complex functions as a DNA-induced molecular clamp. (PubMed id 11276260)^{3, 4} Bravo J.... Warren A.J. (2001)
Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta. (PubMed id 10404215)^{3, 4} Goger M.... Werner M.H. (1999)
Structure of the leukemia-associated human CBFB gene. (PubMed id 9064279)^{3, 4} Hajra A. and Collins F.S. (1996)
Acute myeloid leukemia with Inv (16) produces a chimeric transcription factor with a myosin heavy chain tail. (PubMed id 7587111)^{2, 3} Liu P....Collins F.S. (1994)
Cbfb enhances the osteogenic differentiation of both human and mouse mesenchymal stem cells induced by Cbfa-1 via reducing its ubiquitination-mediated degradation. (PubMed id 17379770)^{1, 3} Lien C.Y....Su Y. (2007)
Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer. (PubMed id 15386419)^{1, 3} Sakakura C....Ito Y. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 865	HGNC: 1539	AceView: CBFB	Ensembl:ENSG00000067955	euGenes: HUgn865
ECgene: CBFB	H-InvDB: CBFB

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CBFB	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CBFB
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CBFB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CBFB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CBFB		Antibodies for CBFB
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CBFB		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CBFB)
	Antibodies (CBFB)
	Chimera RNAi (CBFB)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (CBFb)
	Antibodies (CBFb)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for CBFB

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CBFB

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CBFB Gene at Home site.
Version 2.41.1
server5.xennexinc.com

CBFB Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for CBFB

Summaries
for CBFB

Genomic Location
for CBFB

Proteins
for CBFB

Protein Domains/
Families
for CBFB

Gene Function
for CBFB

Pathways & Interactions
for CBFB

Drugs & Compounds
for CBFB

Transcripts
for CBFB

Expression
for CBFB

Orthologs
for CBFB

Paralogs
for CBFB

SNPs/Variants
for CBFB

Disorders & Mutations
for CBFB

Medical News
for CBFB

Publications
for CBFB

Search for CBFB

Genome Databases showing CBFB

Other Databases showing CBFB

Specialized Databases showing CBFB

Licensable Technologies
for CBFB

Services
for CBFB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CBFB Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor CBFB

Summariesfor CBFB

Genomic Locationfor CBFB

Proteinsfor CBFB

Protein Domains/Familiesfor CBFB

Gene Functionfor CBFB

Pathways & Interactionsfor CBFB

Drugs & Compoundsfor CBFB

Transcriptsfor CBFB

Expression for CBFB

Orthologsfor CBFB

Paralogsfor CBFB

SNPs/Variantsfor CBFB

Disorders & Mutationsfor CBFB

Medical Newsfor CBFB

Publicationsfor CBFB

Search for CBFB

Genome Databases showing CBFB

Other Databases showing CBFB

Specialized Databases showing CBFB

Licensable Technologiesfor CBFB

Servicesfor CBFB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CBFB

Summaries
for CBFB

Genomic Location
for CBFB

Proteins
for CBFB

Protein Domains/
Families
for CBFB

Gene Function
for CBFB

Pathways & Interactions
for CBFB

Drugs & Compounds
for CBFB

Transcripts
for CBFB

Expression
for CBFB

Orthologs
for CBFB

Paralogs
for CBFB

SNPs/Variants
for CBFB

Disorders & Mutations
for CBFB

Medical News
for CBFB

Publications
for CBFB

Licensable Technologies
for CBFB

Services
for CBFB