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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CBFA2T3 Gene

protein-coding   GIFtS: 54
GCID: GC16M088941

core-binding factor, runt domain, alpha subunit 2; translocated...
 Explore 7 diseases affiliated with
CBFA2T3 via
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Biological research products
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Aliases
for CBFA2T3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Core-Binding Factor, Runt Domain, Alpha Subunit 2; Translocated To, 31 2     MTG8-Related Protein 22 3
MTG161 2 3 5     ETO22
MTGR21 2 3 5     MTG8-Related Gene 22
ZMYND41 2 3     Myeloid Translocation Gene 8 And 16b2
Myeloid Translocation Gene On Chromosome 16 Protein2 3     Protein CBFA2T32
Zinc Finger MYND Domain-Containing Protein 42 3     HMTG161

External Ids:    HGNC: 15371   Entrez Gene: 8632   Ensembl: ENSG000001299937   OMIM: 6038705   UniProtKB: O750813   

Export aliases for CBFA2T3 gene to outside databases

Previous GC identifers: GC16P080276 GC16P089937 GC16M088644 GC16M088685 GC16M087468 GC16M074638


Summaries
for CBFA2T3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CBFA2T3:
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors
and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is
one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene
made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This
gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. (provided by
RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: MTG16_HUMAN, O75081
Function: Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid
progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation
Function: Isoform 2 functions as an A-kinase-anchoring protein

Gene Wiki entry for CBFA2T3


Genomic Views
for CBFA2T3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010542.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CBFA2T3 gene promoter:
         Sp1   FOXF2   Tal-1   HTF   Lmo2   Tal-1beta   E47   CP2   HSF2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CBFA2T3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CBFA2T3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBFA2T3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24

CBFA2T3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBFA2T3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M088941:  view genomic region     (about GC identifiers)

Start:
 88,941,266 bp from pter      End:
 89,043,612 bp from pter
Size:
 102,347 bases      Orientation:
 minus strand

Proteins
for CBFA2T3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MTG16_HUMAN, O75081 (See protein sequence)
Recommended Name: Protein CBFA2T3  
Size: 653 amino acids; 71192 Da
Subunit: Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (By similarity). Heterodimer
with RUNX1T1 and CBFA2T2. Interacts with ERBB4, HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, NCOR1, NCOR2, and ZNF652. According
to PubMed:12242670, may not interact with HDAC6. Interacts with PLXNA1, PLXNA3 and PRKAR1A. Isoform 2 interacts with
PRKAR2A, PDE7A and probably PDE4A
Subcellular location: Isoform 1: Nucleus, nucleolus. Note=The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm
Subcellular location: Isoform 2: Nucleus, nucleoplasm. Golgi apparatus membrane
Sequence caution: Sequence=AAH62624.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAA31276.1;
Type=Erroneous gene model prediction; Sequence=BAA31277.1; Type=Erroneous gene model prediction;
Secondary accessions: D3DX78 O60615 O60616 O60617 O75082 O75107 O75108 Q0P5Z6 Q6P5W6
Alternative splicing: 4 isoforms:  O75081-1   O75081-2   O75081-4   O75081-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CBFA2T3: NX_O75081

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75081

    • CBFA2T3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_005178.4  NP_787127.1  

    ENSEMBL proteins: 
     ENSP00000332122   ENSP00000268679   ENSP00000464125   ENSP00000454851   ENSP00000457410  
     ENSP00000456717   ENSP00000454872   ENSP00000454609   ENSP00000456102   ENSP00000395739  
     ENSP00000401254   ENSP00000353449  

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular ----
    GO:0005654nucleoplasm IEA--
    GO:0005730nucleolus IEA--


    CBFA2T3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CBFA2T3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CBFA2T3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR002893 Znf_MYND
     IPR014896 NHR2
     IPR013289 ETO
     IPR013292 MTG16
     IPR003894 TAFH_NHR1

    Graphical View of Domain Structure for InterPro Entry O75081

    ProtoNet protein and cluster: O75081

    2 Blocks protein families:
    IPB002893 Zn-finger
    IPB003894 TAF-like region


    UniProtKB/Swiss-Prot: MTG16_HUMAN, O75081
    Similarity: Belongs to the CBFA2T family
    Similarity: Contains 1 MYND-type zinc finger
    Similarity: Contains 1 TAFH (NHR1) domain


    Function
    for CBFA2T3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MTG16_HUMAN, O75081
    Function: Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid
    progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation
    Function: Isoform 2 functions as an A-kinase-anchoring protein
    Induction: Down-regulated by all-trans retinoic acid (ATRA)

         Genatlas biochemistry entry for CBFA2T3:
    core binding factor Runt domain,alpha subunit 2, translocated to,3,mainly expressed in thymus and possibly in
    monocytes,with several isoforms due to alternative promoters,homolog to Drosophila nervy

    miRNA
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    hsa-miR-199a-3p hsa-miR-15a hsa-miR-128 hsa-miR-219-5p hsa-miR-3916 hsa-miR-4325 hsa-miR-4274 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: CBFA2T3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI16966434
    GO:0008270zinc ion binding IEA--


    CBFA2T3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Cbfa2t3tm1.1Swh for CBFA2T3
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cbfa2t3):
     cellular  hematopoietic system  immune system  no phenotypic analysis 

    CBFA2T3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CBFA2T3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1ErbB4 signaling events
    		ErbB4 signaling events1.00


    1 BioSystems Pathway for CBFA2T3 
        ErbB4 signaling events


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CBFA2T3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/28 Interacting proteins for CBFA2T3 (O750811, 2, 3 ENSP000002686794) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLXNA3P518052, 3, ENSP000003586964MINT-7556975 MINT-7556989 I2D: score=1 STRING: ENSP00000358696
    ZBTB47Q9UFB72, 3, ENSP000004114914MINT-7555667 I2D: score=1 STRING: ENSP00000411491
    ZNF652Q9Y2D91, 3, ENSP000003546864EBI-1190217,EBI-1190229 I2D: score=3 STRING: ENSP00000354686
    PRKAR2AP138613, ENSP000002655634I2D: score=3 STRING: ENSP00000265563
    LDB1Q86U703, ENSP000003924664I2D: score=2 STRING: ENSP00000392466
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0008283cell proliferation TAS9447981
    GO:0030851granulocyte differentiation IDA15231665
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--


    CBFA2T3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CBFA2T3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CBFA2T3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CBFA2T3
    1 Novoseek chemical compound relationship for CBFA2T3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 26.2 2 15231665 (1), 15676213 (1)

    Search CenterWatch for drugs/clinical trials and news about CBFA2T3 / MTG16 

    Transcripts
    for CBFA2T3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CBFA2T3 gene (2 alternative transcripts): 
    NM_005187.5  NM_175931.2  

    Unigene Cluster for CBFA2T3:

    Core-binding factor, runt domain, alpha subunit 2; translocated to, 3
    Hs.513811  [show with all ESTs]
    Unigene Representative Sequence: NM_005187
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327483(uc002fmk.2 uc002fml.2) ENST00000268679(uc002fmm.2 uc002fmn.2)
    ENST00000563856 ENST00000563920 ENST00000566868 ENST00000569464(uc010cif.1)
    ENST00000569443 ENST00000562719 ENST00000563640 ENST00000564416 ENST00000570046
    ENST00000436887 ENST00000448839 ENST00000360302

    miRNA
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    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate CBFA2T3 (see all 83):
    hsa-miR-199a-3p hsa-miR-15a hsa-miR-128 hsa-miR-219-5p hsa-miR-3916 hsa-miR-4325 hsa-miR-4274 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: CBFA2T3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB010419.1 AB010420.1 AF052220.1 AK308355.1 AK314766.1 BC009554.1 BC047019.1 BC062624.1 

    10 DOTS entries:

    DT.91667793  DT.309164  DT.100744991  DT.95359659  DT.100022449  DT.95371800  DT.40221523  DT.91667790 
    DT.95303721  DT.91860989 

    24/83 AceView cDNA sequences (see all 83):

    BC062624 BM914427 BE253496 CA488368 AI424868 BQ188104 BM852310 BQ064149 
    NM_175931 AA483623 NM_005187 BF434339 BC009554 AK097904 AB010420 AK090985 
    BE676580 AI584154 BQ222355 BM727142 BQ064890 H70609 AB010419 BC047019 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CBFA2T3 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
    SP1:                                                                          -           -               
    SP2:                                -                                         -           -               
    SP3:                                                                                      -               
    SP4:                                                                                                      
    SP5:        -                                                                                             


    ECgene alternative splicing isoforms for CBFA2T3

    Expression
    for CBFA2T3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CBFA2T3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CBFA2T3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CBFA2T3

    SOURCE GeneReport for Unigene cluster: Hs.513811

    UniProtKB/Swiss-Prot: MTG16_HUMAN, O75081
    Tissue specificity: Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and
    peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Array including CBFA2T3: 
              Notch Signaling Targets in human mouse rat

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    In Situ
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    Orthologs
    for CBFA2T3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CBFA2T3 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CBFA2T31 core-binding factor, runt domain, alpha subunit 2; more 81.95(n)
    84.83(a)    		   415846  NM_001030580.1  NP_001025751.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CBFA2T36
    		 --
    		 76(a)
    		 1 ↔ 1
    		 GL343487.1(779-24512)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5632521 protein CBFA2T3-like 72.05(n)
    77.19(a)    		   563252  XM_681892.4  XP_686984.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta nvy1 nervy 47.93(n)
    35.82(a)    		   37886  NM_079117.2  NP_523841.3 


    ENSEMBL Gene Tree for CBFA2T3 (if available)
    TreeFam Gene Tree for CBFA2T3 (if available) 

    Paralogs
    for CBFA2T3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CBFA2T3 gene
    CBFA2T22  RUNX1T12  
    6 SIMAP similar genes for CBFA2T3 using alignment to 11 protein entries:     MTG16_HUMAN (see all proteins):
    RUNX1T1    DKFZp313F2116    MTG8    CBFA2T2    CBFA2T1    RUNX1/CBFA2T2 fusion

    CBFA2T3 for paralogs           About GeneDecksing



    Genomic Variants
    for CBFA2T3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2826 NCBI SNPs in CBFA2T3 are shown (see all 2826)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs38095881,2
    		C,--74692334(+) GGCAGA/CGGCTC 1 -- us2k10--------
    rs38095891,2
    		C,--74692361(+) CTGACC/TGAGCC 1 -- us2k14Minor allele frequency- T:0.14NA WA 124
    rs38095901,2
    		H--74692436(+) CACCAC/TGGGGC 1 -- us2k15Minor allele frequency- T:0.00EA NS 1918
    rs38095921,2
    		C,--74692647(+) CTCCCC/TGGCCT 1 -- us2k10--------
    rs38095931,2
    		C,F,--74692791(+) GGAAAG/ACAGAC 1 -- us2k11Minor allele frequency- A:0.03EA 1488
    rs732562061,2
    		C,--74692932(+) CACCCG/ACCAGG 1 -- us2k12Minor allele frequency- A:0.09WA 120
    rs796402991,2
    		--74693332(+) GAGGCC/TCCACG 1 -- us2k10--------
    rs5396361,2
    		C,F,A,--74693357(-) TCTCCA/GGGAAC 1 -- us2k110Minor allele frequency- G:0.12MN NA WA CSA 436
    rs605817281,2
    		--74693476(+) TCACGC/TGGTCA 1 -- us2k10--------
    rs80448501,2
    		C,F,A--74693908(+) CCACAT/GCTGCA 1 -- us2k13Minor allele frequency- G:0.33NA 6

    HapMap Linkage Disequilibrium report for CBFA2T3 (88941266 - 89043612 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 16 variations for CBFA2T3
         7 CNVs: 72689 30017 4976 102361 30016 4975 72688
         9 Indels: 77466 25729 45488 88274 88275 45487 77467 43096 25730

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    Disorders / Diseases
    for CBFA2T3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CBFA2T3 for disorders           About GeneDecksing

    OMIM gene information: 603870    OMIM disorders: --

    UniProtKB/Swiss-Prot: MTG16_HUMAN, O75081
  • Note=A chromosomal aberration involving CBFA2T3 is found in therapy-related myeloid malignancies.
    • Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein

    7 diseases for CBFA2T3:    About MalaCards
    acute myeloid leukemia    myeloid leukemia    leukemia    myeloid malignancy
    breast cancer    acute leukemia    hematopoiesis

    1 disease from the University of Copenhagen DISEASES database for CBFA2T3:
    Leukemia

    3 Novoseek disease relationships for CBFA2T3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 43.3 2 12183414 (1)
    breast cancer 11.5 7 12183414 (4), 12579345 (1)
    tumors 0 8 12183414 (4), 15301688 (2)


    Export disorders for CBFA2T3 gene to outside databases

    Publications
    for CBFA2T3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CBFA2T3 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with CBFA2T3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. (PubMed id 9790752)1, 2, 3, 9 Calabi F. and Cilli V. (1998)
    2. AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation. (PubMed id 15231665)1, 2, 9 Ibanez V.... Saunthararajah Y. (2004)
    3. CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3. (PubMed id 12183414)1, 2, 9 Kochetkova M.... Callen D.F. (2002)
    4. The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. (PubMed id 9596646)1, 2, 9 Gamou T.... Ohki M. (1998)
    5. The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t(16; 21)-positive myeloid malignancies. (PubMed id 12242670)1, 2, 9 Hoogeveen A.T.... Sacchi N. (2002)
    6. Myeloid translocation gene 16b is a dual A-kinase anc horing protein that interacts selectively with plexins in a phospho-regulated m anner. (PubMed id 20138877)1, 2 Fiedler S.E....Carr D.W. (2010)
    7. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)1, 2 Vasilescu J.... Figeys D. (2007)
    8. ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription. (PubMed id 16966434)1, 2 Kumar R.... Callen D.F. (2006)
    9. Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes. (PubMed id 11823486)1, 2 Schillace R.V.... Carr D.W. (2002)
    10. ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. (PubMed id 11533236)1, 2 Amann J.M.... Hiebert S.W. (2001)

    External Searches for CBFA2T3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing CBFA2T3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 863 HGNC: 1537 AceView: CBFA2T3 Ensembl:ENSG00000129993 euGenes: HUgn863
    ECgene: CBFA2T3 H-InvDB: CBFA2T3

    Other Databases showing CBFA2T3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CBFA2T3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CBFA2T3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CBFA2T3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CBFA2T3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CBFA2T3 gene:
    Search GeneIP for patents involving CBFA2T3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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