Aliases for CBFA2T3 Gene
Aliases for CBFA2T3 Gene
- CBFA2/RUNX1 Translocation Partner 3 2 3 5
- Core-Binding Factor, Runt Domain, Alpha Subunit 2; Translocated To, 3 2 3
- Myeloid Translocation Gene On Chromosome 16 Protein 3 4
- Zinc Finger MYND Domain-Containing Protein 4 3 4
- Myeloid Translocation Gene 8 And 16b 2 3
- MTG8-Related Protein 2 3 4
- ZMYND4 3 4
- MTG16 3 4
External Ids for CBFA2T3 Gene
- HGNC: 1537
- Entrez Gene: 863
- Ensembl: ENSG00000129993
- OMIM: 603870
- UniProtKB: O75081
Previous GeneCards Identifiers for CBFA2T3 Gene
- GC16P080276
- GC16P089937
- GC16M088644
- GC16M088685
- GC16M087468
- GC16M088941
- GC16M074638
Summaries for CBFA2T3 Gene
-
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
GeneCards Summary for CBFA2T3 Gene
CBFA2T3 (CBFA2/RUNX1 Translocation Partner 3) is a Protein Coding gene. Diseases associated with CBFA2T3 include Acute Megakaryoblastic Leukemia Without Down Syndrome and Leukemia, Acute Myeloid. Among its related pathways are Hematopoietic Stem Cell Differentiation and Signaling by ERBB4. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is RUNX1T1.
UniProtKB/Swiss-Prot for CBFA2T3 Gene
-
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665).
-
Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBFA2T3 Gene
Genomics for CBFA2T3 Gene
Regulatory Elements for CBFA2T3 Gene
Enhancers for CBFA2T3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CBFA2T3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CBFA2T3 Gene
- Chromosome:
- 16
- Start:
- 88,874,855 bp from pter
- End:
- 88,977,204 bp from pter
- Size:
- 102,350 bases
- Orientation:
- Minus strand
Genomic View for CBFA2T3 Gene
Genes around CBFA2T3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q24.3 by Ensembl
- 16q24.3 by Entrez Gene
- 16q24.3 by HGNC
CBFA2T3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBFA2T3 Gene
Proteins for CBFA2T3 Gene
-
Protein details for CBFA2T3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75081-MTG16_HUMAN
- Recommended name:
- Protein CBFA2T3
- Protein Accession:
- O75081
- D3DX78
- O60615
- O60616
- O60617
- O75082
- O75107
- O75108
- Q0P5Z6
- Q6P5W6
Protein attributes for CBFA2T3 Gene
- Size:
- 653 amino acids
- Molecular mass:
- 71192 Da
- Quaternary structure:
-
- Homooligomer. Homotetramerization is mediated by nervy homology region 2 (NRH2) (By similarity). Can interact with RUNX1T1 and CBFA2T2; heterotetramerization between members of the CBFA2T family is proposed (PubMed:12242670). Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (By similarity). Interacts with ERBB4, HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, NCOR1, NCOR2, and ZNF652. According to PubMed:12242670, may not interact with HDAC6. Interacts with PLXNA1, PLXNA3 and PRKAR1A. Isoform 2 interacts with PRKAR2A, PDE7A and probably PDE4A. Interacts with ZBTB4, ZBTB38 and ZBTB33. Interacts with HIF1A and EGLN1. Interacts with the AML1-MTG8/ETO fusion protein.
- SequenceCaution:
-
- Sequence=AAH62624.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAA31276.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA31277.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for CBFA2T3 Gene
Post-translational modifications for CBFA2T3 Gene
Other Protein References for CBFA2T3 Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CBFA2T3
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-
Abcam antibodies for CBFA2T3
- Invitrogen Antibodies for CBFA2T3
- antibodies-online Antibodies for CBFA2T3: See all 26
- GeneTex CBFA2T3 antibody for CBFA2T3
-
Santa Cruz Biotechnology (SCBT) Antibodies for CBFA2T3
Protein Products
-
OriGene Purified Proteins for CBFA2T3
- Search Origene for MassSpec and Protein Over-expression Lysates for CBFA2T3
- Origene Custom Protein Services for CBFA2T3
- antibodies-online Proteins for CBFA2T3: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CBFA2T3
-
Abcam proteins for CBFA2T3
Assay Products
No data available for DME Specific Peptides for CBFA2T3 Gene
Domains & Families for CBFA2T3 Gene
Gene Families for CBFA2T3 Gene
Protein Domains for CBFA2T3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CBFA2T3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O75081UniProtKB/Swiss-Prot:
MTG16_HUMAN :- Nervy homology region 2 (NHR2) mediates homo- and possibly heterotypic oligomerization by forming a four-helix bundle tetrameric structure.
- Belongs to the CBFA2T family.
- Domain:
-
- Nervy homology region 2 (NHR2) mediates homo- and possibly heterotypic oligomerization by forming a four-helix bundle tetrameric structure.
- Family:
-
- Belongs to the CBFA2T family.
Function for CBFA2T3 Gene
Molecular function for CBFA2T3 Gene
- GENATLAS Biochemistry:
- core binding factor Runt domain,alpha subunit 2, translocated to,3,mainly expressed in thymus and possibly in monocytes,with several isoforms due to alternative promoters,homolog to Drosophila nervy
- UniProtKB/Swiss-Prot Function:
- Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665).
- UniProtKB/Swiss-Prot Function:
- Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486).
- UniProtKB/Swiss-Prot Induction:
- Down-regulated by all-trans retinoic acid (ATRA).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0003714 | transcription corepressor activity | TAS,IEA | 23251453 |
| GO:0005515 | protein binding | IPI | 16966434 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for CBFA2T3 Gene
- MGI mutant phenotypes for CBFA2T3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CBFA2T3:
Animal Models for CBFA2T3 Gene
- MGI Knock Outs for CBFA2T3:
-
- Cbfa2t3 tm1.1Swh
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBFA2T3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CBFA2T3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBFA2T3 gene
- Search ViGene Biosciences for CBFA2T3
CRISPR Products
-
OriGene CRISPR knockouts for CBFA2T3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBFA2T3
- GenScript: Design CRISPR guide RNA sequences for CBFA2T3
miRNA for CBFA2T3 Gene
- miRTarBase miRNAs that target CBFA2T3
-
- hsa-mir-1273e (MIRT688796)
- hsa-mir-4709-3p (MIRT688797)
- hsa-mir-937-3p (MIRT688798)
- hsa-mir-6755-3p (MIRT688799)
- hsa-mir-15b-3p (MIRT688800)
- hsa-mir-4635 (MIRT688801)
- hsa-mir-4433a-3p (MIRT688802)
- hsa-mir-4459 (MIRT688803)
- hsa-mir-4768-3p (MIRT688804)
- hsa-mir-195-5p (MIRT728044)
- hsa-mir-16-5p (MIRT728045)
- hsa-mir-15b-5p (MIRT728046)
- hsa-mir-15a-5p (MIRT728047)
miRNA Products
- Search ViGene Biosciences for CBFA2T3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBFA2T3
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CBFA2T3
-
ViGene Biosciences adenoviral particle packaged cDNA for CBFA2T3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CBFA2T3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBFA2T3 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBFA2T3 Gene
Localization for CBFA2T3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CBFA2T3 Gene
- Isoform 1: Nucleus, nucleolus. Note=The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm.
- Isoform 2: Nucleus, nucleoplasm. Golgi apparatus membrane.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| golgi apparatus | 3 |
| cytosol | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005634 | nucleus | IBA,IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005730 | nucleolus | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
Pathways & Interactions for CBFA2T3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by ERBB4 | ||
| 2 | Hematopoietic Stem Cell Differentiation | ||
Pathways by source for CBFA2T3 Gene
2 BioSystems pathways for CBFA2T3 Gene
Interacting Proteins for CBFA2T3 Gene
Selected Interacting proteins:
O75081-MTG16_HUMAN
ENSP00000268679
for CBFA2T3 Gene via
IID
STRING
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IDA | 23840896 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0008283 | cell proliferation | TAS | 9447981 |
| GO:0008285 | negative regulation of cell proliferation | IDA | 23840896 |
No data available for SIGNOR curated interactions for CBFA2T3 Gene
Transcripts for CBFA2T3 Gene
mRNA/cDNA for CBFA2T3 Gene
- (5) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (83) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CBFA2T3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CBFA2T3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBFA2T3
- GenScript: Design CRISPR guide RNA sequences for CBFA2T3
miRNA Products
- Search ViGene Biosciences for CBFA2T3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBFA2T3
- Browse OriGene Inhibitory RNA Products For CBFA2T3
-
ViGene Biosciences ready-to-package AAV shRNAs for CBFA2T3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CBFA2T3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBFA2T3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||
| SP6: |
Expression for CBFA2T3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Plasmacytoid Dendritic cells Peripheral Blood
- Hematopoietic Bone Marrow
-
Heart (Cardiovascular System)
- Cardiac Crescent Cells Cardiac Crescent
mRNA differential expression in normal tissues according to GTEx for CBFA2T3 Gene
This gene is overexpressed in Brain - Cerebellum (x4.6) and Brain - Cerebellar Hemisphere (x4.3).
This gene is overexpressed in Bone marrow mesenchymal stem cell (50.1), Monocytes (11.9), and Gallbladder (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CBFA2T3 Gene
NURSA nuclear receptor signaling pathways regulating expression of CBFA2T3 Gene:
CBFA2T3SOURCE GeneReport for Unigene cluster for CBFA2T3 Gene:
Hs.513811mRNA Expression by UniProt/SwissProt for CBFA2T3 Gene:
O75081-MTG16_HUMAN
Tissue specificity:
Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level).
Evidence on tissue expression from TISSUES for CBFA2T3 Gene
- Pancreas(4.2)
- Nervous system(4.2)
- Liver(4.1)
- Lung(4.1)
Primer Products
-
OriGene qPCR primer pairs for CBFA2T3
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CBFA2T3 Gene
Orthologs for CBFA2T3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CBFA2T3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CBFA2T3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CBFA2T3 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cbfa2t3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cbfa2t3 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CBFA2T3 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CBFA2T3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CBFA2T3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CBFA2T3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cbfa2t3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC563252 34 |
|
||
| CBFA2T3 35 |
|
OneToOne | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9080 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | nvy 34 35 |
|
- Species where no ortholog for CBFA2T3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CBFA2T3 Gene
(6) SIMAP similar genes for CBFA2T3 Gene using alignment to 11 proteins:
Variants for CBFA2T3 Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs553618592 | A colorectal cancer sample | 88,879,331(+) | GCTTC(A/G)CCTCG | downstream-variant-500B, reference, missense | |
| rs745972870 | A colorectal cancer sample | 88,885,246(+) | GGTCG(C/T)GGTCT | intron-variant, nc-transcript-variant, reference, missense | |
| rs774310781 | A colorectal cancer sample | 88,879,380(+) | GAGCT(C/T)GTGCG | downstream-variant-500B, reference, missense | |
| rs1000007589 | -- | 88,945,147(+) | TGGCT(A/G)ATGGA | intron-variant | |
| rs1000010322 | -- | 88,944,171(+) | TCTCT(A/T)CTAAA | intron-variant |
Residual Variation Intolerance Score:
88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.94;
59.67% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CBFA2T3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CBFA2T3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBFA2T3 Gene
Disorders for CBFA2T3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acute megakaryoblastic leukemia without down syndrome |
|
|
| leukemia, acute myeloid |
|
|
Search CBFA2T3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MTG16_HUMAN- Note=A chromosomal aberration involving CBFA2T3 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein. {ECO:0000269 PubMed:10995019, ECO:0000269 PubMed:11224496, ECO:0000269 PubMed:9596646}.
Relevant External Links for CBFA2T3
No data available for Genatlas for CBFA2T3 Gene
Publications for CBFA2T3 Gene
- CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. (PMID: 9790752) Calabi F. … Cilli V. (Genomics 1998) 2 3 4 22 64
- AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation. (PMID: 15231665) Ibanez V. … Saunthararajah Y. (Cancer Res. 2004) 3 4 22 64
- CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3. (PMID: 12183414) Kochetkova M. … Callen D.F. (Cancer Res. 2002) 3 4 22 64
- The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t(16; 21)-positive myeloid malignancies. (PMID: 12242670) Hoogeveen A.T. … Sacchi N. (Oncogene 2002) 3 4 22 64
- The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. (PMID: 9596646) Gamou T. … Ohki M. (Blood 1998) 3 4 22 64
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- Abcam antibodies for CBFA2T3
- Abcam proteins for CBFA2T3
- Search for Assays for CBFA2T3 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- antibodies-online Antibodies for CBFA2T3: See all 26
- Search antibodies-online for kits
- antibodies-online Proteins for CBFA2T3: See all 7
- Search antibodies-online for peptides
- GeneTex CBFA2T3 antibody for CBFA2T3
- Search GeneTex for Proteins for CBFA2T3
- ViGene Biosciences adenoviral particle packaged cDNA for CBFA2T3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CBFA2T3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CBFA2T3 gene
- Search ViGene Biosciences for CBFA2T3
- Santa Cruz Biotechnology (SCBT) Antibodies for CBFA2T3
- Search Santa Cruz Biotechnology (SCBT) for CBFA2T3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CBFA2T3
- Horizon Cell Lines for CBFA2T3
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBFA2T3
- VectorBuilder custom plasmid, inducible vectors for CBFA2T3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBFA2T3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CBFA2T3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer