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RUNX1T1 Gene

protein-coding GIFtS: 56

GC08M093041

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
(Previous names: core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: AML1T1, CBFA2T1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AML1T1 ^², ³
CBFA2T1 ^², ³
CDR ^¹, ², ³
ETO ^¹, ², ³
MGC2796 ^²
MTG8 ^¹, ², ³
MTG8b ^²
ZMYND2 ^¹, ², ³

Descriptions
Cyclin-D-related protein ^³
Eight twenty one protein ^², ³
Protein ETO ^³
Protein MTG8 ^³
Zinc finger MYND domain-containing protein 2 ^³
acute myelogenous leukemia 1 translocation 1 protein ^²
acute myelogenous leukemia 1 translocation 1, cyclin-D related ^²
core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related ^¹, ²
myeloid translocation gene on 8q22 ^²
runt-related transcription factor 1; translocated to, 1 (cyclin D-related) ^²

External Ids
HGNC: 1535¹
Entrez Gene: 862²
UniProtKB: Q06455³
Ensembl: ENSG00000079102⁷

Search outside databases for aliases for RUNX1T1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RUNX1T1:

The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In

acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of

the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of

the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric

protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block

hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been

found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: MTG8_HUMAN, Q06455

Function: Transcription regulator that excerts its function by binding to histone deacetylases and

transcription factors. Can repress transactivation mediated by TCF12

Gene Wiki entry for RUNX1T1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RUNX1T1 gene

Entrez Gene cytogenetic band: 8q22 Ensembl cytogenetic band: 8q21.3 HGNC cytogenetic band: 8q22

RUNX1T1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M093041: (about GC identifiers)

Start:	93,040,328 bp from pter
End:	93,176,619 bp from pter
Size:	136,292 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_008046.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MTG8_HUMAN, Q06455 (See protein sequence)

Recommended Name: Protein CBFA2T1

Size: 604 amino acids; 67566 Da

Subunit: Homotetramer, and heterotetramer with CBFA2T2 and CBFA2T3. Interacts with TCF12, SIN3A,

HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2

Subcellular location: Nucleus (Potential)

PDB structures from and Proteopedia :

1WQ6 (3D)

2DJ8 (3D)

2H7B (3D)

2OD1 (3D)

2ODD (3D)

2PP4 (3D)

Secondary accessions: O14784 Q06456 Q14873 Q16239 Q16346 Q16347 Q6IBL1 Q92479 Q9BRZ0

Alternative splicing: 2 isoforms: Q06455-1 Q06455-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_004340.1 NP_783552.1 NP_783553.1 NP_783554.1

ENSEMBL proteins:

ENSP00000379520 ENSP00000353504 ENSP00000265814

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (RUNX1T1 / ETO)
	Human Recombinant Proteins from Abnova (RUNX1T1)

OriGene Purified Recombinant Human Proteins (see all 2): RUNX1T1

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

About this table

Antibodies for RUNX1T1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for RUNX1T1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for RUNX1T1 (ETO)
	Antibodies from Abcam (RUNX1T1 / ETO), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RUNX1T1)
	Novus Biologicals Antibodies for RUNX1T1

Assays for RUNX1T1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q06455

ProtoNet protein and cluster: Q06455

2 Blocks protein families:

IPB002893 Zn-finger

IPB003894 TAF-like region

UniProtKB/Swiss-Prot: MTG8_HUMAN, Q06455

Domain: The TAFH domain mediates interaction with transcription regulators

Similarity: Belongs to the CBFA2T family

Similarity: Contains 1 MYND-type zinc finger

Similarity: Contains 1 TAFH (NHR1) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RUNX1T1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RUNX1T1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_004349

Applied Biosystems Silencer® siRNAs for RUNX1T1

Sigma-Aldrich siRNA for RUNX1T1

Sigma-Aldrich shRNA for RUNX1T1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RUNX1T1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_004349
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_004349
untagged cDNA clones in CMV expression vector (see all 5): NM_004349

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_175634

UniProtKB/Swiss-Prot: MTG8_HUMAN, Q06455

Function: Transcription regulator that excerts its function by binding to histone deacetylases and

transcription factors. Can repress transactivation mediated by TCF12

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Runx1t1):

digestive/alimentary

growth/size

lethality-prenatal/perinatal

normal

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	9618262
GO:0005515	protein binding	IPI	16966434 17353931
GO:0008270	zinc ion binding	IEA	--
GO:0016564	transcription repressor activity	IEA	--
GO:0042803	protein homodimerization activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for RUNX1T1

5/35 Interacting proteins for RUNX1T1 (Q06455^{1, 2} ENSP00000265814³) via UniProtKB, MINT, and/or STRING (see all 35 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZNF652	Q9Y2D9¹, ENSP00000354686³	EBI-743342, EBI-1190229 STRING (score=.807)
OTUD4	Q01804¹	EBI-743342, EBI-1054396
THRAP3	Q9Y2W1¹	EBI-743342, EBI-352039
ATN1	P54259²	MINT-2857407
UBQLN4	Q9NRR5²	MINT-2857388

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006091	generation of precursor metabolites and energy	TAS	9618262
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0045444	fat cell differentiation	IEA	--
GO:0051101	regulation of DNA binding	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RUNX1T1
4 Novoseek chemical compound relationships for RUNX1T1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	33.64	9	15109542 (2), 8334990 (1), 15377655 (1), 7812194 (1) (see all 6)
proline	4.80	2	7812194 (1)
oligonucleotide	0.00	1	8499624 (1)
threonine	0.00	3	10076566 (2), 8781439 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RUNX1T1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RUNX1T1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_004349

Sigma-Aldrich siRNA for RUNX1T1

Sigma-Aldrich shRNA for RUNX1T1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004349 NM_175634 NM_175635 NM_175636

REFSEQ mRNAs for RUNX1T1 gene (4 alternative transcripts):

NM_004349.2 NM_175634.1 NM_175635.1 NM_175636.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004349 NM_175634 NM_175635 NM_175636

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_004349
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_004349
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_004349

Additional cDNA sequence:

AF018283.1 AK057707.1 AK297616.1 AK312592.1 BC005850.1 BC067078.1 BC139783.1 BT009871.1

CR456792.1 CR619328.1 D14289.1 D14821.1 D43638.1 S82690.1 X79990.1 Z35296.1

24/28 DOTS entries (see all 28 ):

DT.95267501 DT.121484056 DT.92474135 DT.95267503 DT.92474122 DT.65285691 DT.95267502 DT.121484123

DT.40191474 DT.121484036 DT.121484082 DT.121484027 DT.121484113 DT.92474131 DT.121484088 DT.215536

DT.407290 DT.100023769 DT.121484092 DT.121484105 DT.406088 DT.95207072 DT.121484035 DT.121484103

24/83 AceView cDNA sequences (see all 83 ):

BT009871 AL536357 H80492 AA992855 BQ632275 CA849037 F02579 NM_175635

AU117637 N75054 AK057707 AL599454 CR619328 H46979 NM_175634 BC005850

H94855 X79990 BC067078 AI804854 CA844294 CA844355 NM_175636 CA848975

highest scoring ESTs for RUNX1T1:

AW409814 AW411004 AW898376 BC005850 BC067078 N75403 AA247686 AA463390 AA506749 AA904353

Unigene Cluster for RUNX1T1:

Runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

Hs.368431 [show with all ESTs]

Unigene Representative Sequence: NM_004349

GeneLoc Exon Structure

5/26 Alternative Splicing Database (ASD) splice patterns (SP) for RUNX1T1 (see all 26 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	·	9d	·	9e	·	9f	^	10a	·	10b	·
SP1:																									-		-		-		-		-		-		-		-
SP2:																			-		-		-		-		-		-		-		-		-		-		-
SP3:																																			-		-		-
SP4:
SP5:											-		-		-				-						-		-		-		-		-		-		-		-

ExUns:	10c	·	10d	·	10e	·	10f	·	10g	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b
SP1:													-						-
SP2:													-						-
SP3:													-						-
SP4:													-						-
SP5:

About this scheme

ECgene alternative splicing isoforms for RUNX1T1

3 Ensembl transcripts including schematic representations:

ENST00000396218 ENST00000360348 ENST00000265814

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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RUNX1T1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RUNX1T1

¹ / ² / ³

13 probe-sets matching RUNX1T1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35641_g_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.53	D14822	0.20	1.00	0.72	1
35638_at²^{, 3}	U95-A	2	1.00	0.97	0.70	1.55	D43638	0.60	1.00	0.82	1
35639_at*²^{, 3}	U95-A	1	1.00	1.00	0.26	0.33	D14823	0.20	1.00	0.72	1
35640_at*²^{, 3}	U95-A	1	1.00	1.00	0.47	0.30	D14822	0.20	1.00	0.72	1
205529_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004349	0.60	1.00	0.82	1
205528_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X79990	0.60	1.00	0.82	1
216832_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF018283	0.60	1.00	0.82	1
216831_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF018283	0.60	1.00	0.82	1
205529_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205528_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216832_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216831_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1564642_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks RUNX1T1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.368431
UniProtKB/Swiss-Prot: MTG8_HUMAN, Q06455
Tissue specificity: Most abundantly expressed in brain. Lower levels in lung, heart, testis and
ovary

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RUNX1T1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RUNX1T1¹	--	runt-related transcription factor 1; translocated to, more	93.1(n) 99.17(a)	487044 XM_845321.1 XP_850414.1
chimpanzee (Pan troglodytes)	RUNX1T1¹	--	runt-related transcription factor 1; translocated to, more	98.13(n) 98.47(a)	472816 XM_528188.2 XP_528188.2
cow (Bos taurus)	RUNX1T1¹	--	runt-related transcription factor 1; translocated to, more	92.4(n) 99.29(a)	538628 XM_876426.2 XP_881519.1
rat (Rattus norvegicus)	Runx1t1¹	--	runt-related transcription factor 1; translocated to, more	91.94(n) 98.51(a)	362489 XM_342808.3 XP_342809.3
mouse (Mus musculus)	Runx1t1^{1, 5}	4 (4.40 cM)⁵	runt-related transcription factor 1; translocated to, more^{1, 5}	91.94(n)¹ 99.3(a)¹	12395¹ NM_009822.1¹ NP_033952.1¹ AB221624⁵ AK032132⁵ (see all 23)

About this table Species with no ortholog for RUNX1T1

ENSEMBL Gene Tree for RUNX1T1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RUNX1T1 gene

CBFA2T3² CBFA2T2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/585 NCBI SNPs in RUNX1T1 are shown (see all 585 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 200)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7005007^1,2	A,C,F,H	93158380(+)	`CTCAAC/TAAATG`	2	--	int¹ ng3¹		7		EU EA WA NA	558
	rs7461004^1,2	A,C,F,H	93158004(+)	`TTGTTG/TCGCTG`	2	--	int¹ ng3¹		7		EU EA WA NA	690
	rs4458918^1,2	A,C,F,H	93145729(+)	`AATTCA/GTAACG`	3	--	ng3¹ int¹		10		EU EA WA NA	1018
--	rs1046839^1,2	A,C	93040818(-)	`acacaC/GaAGTA`	4	--	ut3¹ ese³		0	--	--	--	--
	rs11991663^1,2	C,H	93099015(+)	`GCTTAG/AGCAGA`	4	--	int¹ ut5¹		4		EU EA WA	418
	rs2737806^1,2	H	93039875(-)	`CTTTAA/CCACTG`	4	--	ng5¹		4		EU EA WA	410
	rs4425799^1,2	H	93145803(+)	`TCTTAG/ATTAGA`	3	--	int¹ ng3¹		4		EU EA WA	418
	rs2737804^1,2	H	93040067(-)	`AGTCGT/AGGAAT`	4	--	ng5¹		4		EU EA WA	420
	rs2737802^1,2	H	93041046(-)	`TTCGGT/CTTTTT`	4	--	ut3¹ trp³		4		EU EA WA	416
	rs734113^1,2	A,C,F,H,O	93129271(-)	`TGGGTA/GGATAA`	3	--	int¹		7		EA NA EU WA	518

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HapMap Linkage Disequilibrium images for RUNX1T1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 133435

UniProtKB/Swiss-Prot: MTG8_HUMAN, Q06455

A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2).

Translocation t(8;21)(q22;q22) with RUNX1/AML1

Defects in RUNX1T1 may be a cause of colorectal cancer (CRC) [MIM:114500]

10/11 Novoseek disease relationships for RUNX1T1 gene (see all 11 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemogenesis	79.20	2	10076566 (1), 8781439 (1)
minimal residual disease	65.01	1	7553157 (1)
leukemia	62.05	11	15723339 (2), 15231665 (1), 16893685 (1), 17572682 (1) (see all 8)
chromosomal aberrations	56.63	2	15231665 (1), 8427996 (1)
myeloid leukemia	55.52	2	17572682 (1), 10675041 (1)
aml childhood	53.83	2	12557226 (1)
hematologic malignancies	48.86	1	14551142 (1)
promyelocytic leukemia	43.01	2	10688654 (1), 10951564 (1)
acute leukemia	37.39	1	14551142 (1)
leukemia promyelocytic acute	24.83	1	14551142 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/163 PubMed articles for RUNX1T1 gene (see all 163 ):

Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells. (PubMed id 7541640)^{1, 3, 4} Era T.... Takatsuki K. (1995)
Structure and expression of the human MTG8/ETO gene. (PubMed id 9661669)^{1, 3, 4} Wolford J.K. and Prochazka M. (1998)
CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. (PubMed id 9790752)^{1, 2, 3} Calabi F. and Cilli V. (1998)
The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. (PubMed id 8334990)^{1, 3, 4} Miyoshi H.... Ohki M. (1993)
Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells. (PubMed id 1423235)^{1, 3, 4} Nisson P.E.... Sacchi N. (1992)
The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity. (PubMed id 16616331)^{3, 4} Liu Y....Bushweller J.H. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t(16; 21)-positive myeloid malignancies. (PubMed id 12242670)^{3, 4} Hoogeveen A.T.... Sacchi N. (2002)
Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8;21) of acute myeloid leukemia M2. (PubMed id 7919324)^{3, 4} Tighe J.E. and Calabi F. (1994)
The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved putative transcription factor. (PubMed id 8137293)^{3, 4} Erickson P.F.... Drabkin H.A. (1994)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 862	HGNC: 1535	AceView: CBFA2T1	Ensembl:ENSG00000079102	euGenes: HUgn862
ECgene: RUNX1T1	H-InvDB: RUNX1T1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RUNX1T1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for RUNX1T1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for RUNX1T1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RUNX1T1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RUNX1T1		Antibodies for RUNX1T1
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Recombinant Proteins (RUNX1T1)
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Antibodies & Assays for RUNX1T1 (ETO)

	Recombinant Proteins (RUNX1T1 / ETO)
	Antibodies (RUNX1T1 / ETO)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for RUNX1T1

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Antibodies for RUNX1T1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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RUNX1T1 Gene at Home site.
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RUNX1T1 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for RUNX1T1

Summaries
for RUNX1T1

Genomic Location
for RUNX1T1

Proteins
for RUNX1T1

Protein Domains/
Families
for RUNX1T1

Gene Function
for RUNX1T1

Pathways & Interactions
for RUNX1T1

Drugs & Compounds
for RUNX1T1

Transcripts
for RUNX1T1

Expression
for RUNX1T1

Orthologs
for RUNX1T1

Paralogs
for RUNX1T1

SNPs/Variants
for RUNX1T1

Disorders & Mutations
for RUNX1T1

Medical News
for RUNX1T1

Publications
for RUNX1T1

Search for RUNX1T1

Genome Databases showing RUNX1T1

Other Databases showing RUNX1T1

Specialized Databases showing RUNX1T1

Licensable Technologies
for RUNX1T1

Services
for RUNX1T1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RUNX1T1 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor RUNX1T1

Summariesfor RUNX1T1

Genomic Locationfor RUNX1T1

Proteinsfor RUNX1T1

Protein Domains/Familiesfor RUNX1T1

Gene Functionfor RUNX1T1

Pathways & Interactionsfor RUNX1T1

Drugs & Compoundsfor RUNX1T1

Transcriptsfor RUNX1T1

Expression for RUNX1T1

Orthologsfor RUNX1T1

Paralogsfor RUNX1T1

SNPs/Variantsfor RUNX1T1

Disorders & Mutationsfor RUNX1T1

Medical Newsfor RUNX1T1

Publicationsfor RUNX1T1

Search for RUNX1T1

Genome Databases showing RUNX1T1

Other Databases showing RUNX1T1

Specialized Databases showing RUNX1T1

Licensable Technologiesfor RUNX1T1

Servicesfor RUNX1T1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RUNX1T1

Summaries
for RUNX1T1

Genomic Location
for RUNX1T1

Proteins
for RUNX1T1

Protein Domains/
Families
for RUNX1T1

Gene Function
for RUNX1T1

Pathways & Interactions
for RUNX1T1

Drugs & Compounds
for RUNX1T1

Transcripts
for RUNX1T1

Expression
for RUNX1T1

Orthologs
for RUNX1T1

Paralogs
for RUNX1T1

SNPs/Variants
for RUNX1T1

Disorders & Mutations
for RUNX1T1

Medical News
for RUNX1T1

Publications
for RUNX1T1

Licensable Technologies
for RUNX1T1

Services
for RUNX1T1