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Aliases for CBARP Gene

Aliases for CBARP Gene

  • CACN Beta Subunit Associated Regulatory Protein 2 3
  • Calcium Channel, Voltage-Dependent, Beta Subunit Associated Regulatory Protein 2 3 5
  • VGCC Beta-Anchoring And -Regulatory Protein 2 3
  • C19orf26 3 4
  • Chromosome 19 Open Reading Frame 26 2
  • Downstream Of STK11 2
  • Downstream Of Stk11 3
  • Protein Dos 3
  • BARP 3
  • DOS 3

External Ids for CBARP Gene

Previous HGNC Symbols for CBARP Gene

  • C19orf26

Summaries for CBARP Gene

GeneCards Summary for CBARP Gene

CBARP (CACN Beta Subunit Associated Regulatory Protein) is a Protein Coding gene. Diseases associated with CBARP include Meibomian Cyst and Morgagni Cataract.

UniProtKB/Swiss-Prot for CBARP Gene

  • Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBARP Gene

Genomics for CBARP Gene

Regulatory Elements for CBARP Gene

Enhancers for CBARP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CBARP on UCSC Golden Path with GeneCards custom track

Promoters for CBARP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CBARP on UCSC Golden Path with GeneCards custom track

Genomic Location for CBARP Gene

Chromosome:
19
Start:
1,228,287 bp from pter
End:
1,241,763 bp from pter
Size:
13,477 bases
Orientation:
Minus strand

Genomic View for CBARP Gene

Genes around CBARP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBARP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBARP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBARP Gene

Proteins for CBARP Gene

  • Protein details for CBARP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N350-CBARP_HUMAN
    Recommended name:
    Voltage-dependent calcium channel beta subunit-associated regulatory protein
    Protein Accession:
    Q8N350
    Secondary Accessions:
    • K7EJP2
    • O43385

    Protein attributes for CBARP Gene

    Size:
    705 amino acids
    Molecular mass:
    73929 Da
    Quaternary structure:
    • Interacts with voltage-dependent calcium channels CACNB1, CACNB2, CACNB3 and CACNB4 beta subunits; prevents their interaction with the CACNA1C alpha subunit thereby negatively regulating the activity of the corresponding calcium channels.
    SequenceCaution:
    • Sequence=AAC04305.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH28156.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CBARP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CBARP Gene

Proteomics data for CBARP Gene at MOPED

Post-translational modifications for CBARP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CBARP Gene

No data available for DME Specific Peptides for CBARP Gene

Domains & Families for CBARP Gene

Protein Domains for CBARP Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CBARP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CBARP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CBARP Gene

Function for CBARP Gene

Molecular function for CBARP Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis.
genes like me logo Genes that share phenotypes with CBARP: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CBARP Gene

Localization for CBARP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBARP Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type III membrane protein. Cell membrane; Single-pass type III membrane protein. Cell projection, growth cone.

Gene Ontology (GO) - Cellular Components for CBARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0030426 colocalizes_with growth cone ISS --
GO:0030672 synaptic vesicle membrane IEA --
genes like me logo Genes that share ontologies with CBARP: view

No data available for Subcellular locations from COMPARTMENTS for CBARP Gene

Pathways & Interactions for CBARP Gene

SuperPathways for CBARP Gene

No Data Available

Interacting Proteins for CBARP Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000215376%0d%0a9606.ENSP00000265094%0d%0a
Selected Interacting proteins: ENSP00000215376 for CBARP Gene via STRING

Symbol External ID(s) Details
FBXW11

Gene Ontology (GO) - Biological Process for CBARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903170 negative regulation of calcium ion transmembrane transport ISS --
genes like me logo Genes that share ontologies with CBARP: view

No data available for Pathways by source and SIGNOR curated interactions for CBARP Gene

Drugs & Compounds for CBARP Gene

No Compound Related Data Available

Transcripts for CBARP Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CBARP Gene

No ASD Table

Relevant External Links for CBARP Gene

GeneLoc Exon Structure for
CBARP
ECgene alternative splicing isoforms for
CBARP

Expression for CBARP Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CBARP Gene

Orthologs for CBARP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CBARP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf26 35
  • 98.07 (n)
  • 97.87 (a)
C19orf26 36
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C19orf26 36
  • 43 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C19orf26 36
  • 39 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C19orf26 36
  • 37 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dos 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C19orf26 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C19orf26 36
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C22H19orf26 (1 of 2) 36
  • 29 (a)
OneToMany
C22H19orf26 (2 of 2) 36
  • 10 (a)
OneToMany
Species with no ortholog for CBARP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBARP Gene

ENSEMBL:
Gene Tree for CBARP (if available)
TreeFam:
Gene Tree for CBARP (if available)

Paralogs for CBARP Gene

No data available for Paralogs for CBARP Gene

Variants for CBARP Gene

Sequence variations from dbSNP and Humsavar for CBARP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12977299 -- 1,232,559(+) ACAGA(C/T)GGGAC intron-variant
rs13346715 -- 1,235,072(+) CGGCC(C/T)GTGGA reference, synonymous-codon
rs71335352 -- 1,231,601(+) CTGTG(-/C)CCCCC intron-variant
rs8109164 -- 1,235,257(+) CGGCA(C/T)GGGCG intron-variant
rs8110590 -- 1,231,143(+) GGGGG(A/C/T)GCGGG reference, missense

Variation tolerance for CBARP Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CBARP Gene

Disorders for CBARP Gene

MalaCards: The human disease database

(3) MalaCards diseases for CBARP Gene - From: DISEASES

Disorder Aliases PubMed IDs
meibomian cyst
  • chalazion
morgagni cataract
  • hypermature cataract
miller-dieker lissencephaly syndrome
  • mds
- elite association - COSMIC cancer census association via MalaCards
Search CBARP in MalaCards View complete list of genes associated with diseases

Relevant External Links for CBARP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBARP
genes like me logo Genes that share disorders with CBARP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CBARP Gene

Publications for CBARP Gene

  1. BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis. (PMID: 24751537) BAcguin P. … Hunziker W. (J. Cell Biol. 2014) 2 3 67
  2. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3

Products for CBARP Gene

Sources for CBARP Gene

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