Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CAVIN3 Gene

Aliases for CAVIN3 Gene

  • Caveolae Associated Protein 3 2 3 5
  • Serum Deprivation Response Factor-Related Gene Product That Binds To C-Kinase 3 4
  • Sdr-Related Gene Product That Binds To C-Kinase 2 3
  • Protein Kinase C Delta Binding Protein 2 3
  • Cavin-3 3 4
  • PRKCDBP 3 4
  • HSRBC 3 4
  • SRBC 3 4
  • Protein Kinase C, Delta Binding Protein 2
  • Protein Kinase C Delta-Binding Protein 4
  • Caveolae-Associated Protein 3 3

External Ids for CAVIN3 Gene

Previous HGNC Symbols for CAVIN3 Gene

  • PRKCDBP

Summaries for CAVIN3 Gene

Entrez Gene Summary for CAVIN3 Gene

  • The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAVIN3 Gene

CAVIN3 (Caveolae Associated Protein 3) is a Protein Coding gene. Diseases associated with CAVIN3 include Hereditary Spherocytosis. Among its related pathways are Circadian rythm related genes and ADP signalling through P2Y purinoceptor 12. An important paralog of this gene is CAVIN2.

UniProtKB/Swiss-Prot for CAVIN3 Gene

  • Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).

Additional gene information for CAVIN3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAVIN3 Gene

Genomics for CAVIN3 Gene

Regulatory Elements for CAVIN3 Gene

Enhancers for CAVIN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H006601 1.4 ENCODE dbSUPER 20 -286.9 -286850 12 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 RRP8 ILK FAM160A2 CAVIN3 DNHD1 ENSG00000254641 DCHS1 ENSG00000254400
GH11H006317 1.1 ENCODE dbSUPER 25.2 -0.3 -258 6 TBP PKNOX1 BATF RFX5 RCOR1 FOS ETV6 RUNX3 CREM IKZF2 CAVIN3 OR56A1 TAF10 GC11M006313
GH11H006742 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -424.6 -424586 6 HDAC1 PKNOX1 RB1 NFRKB SIN3A YBX1 BATF TCF12 ZNF766 GATA2 ILK OR2AG2 CAVIN3 RRP8 ENSG00000254641 TAF10 OR10A4 APBB1 SMPD1 OR2AG1
GH11H006400 1.3 Ensembl ENCODE dbSUPER 9.4 -82.7 -82723 5 SOX13 MXI1 TBL1XR1 BATF POLR2A EED SCRT2 NR2F6 ETV6 RUNX3 SMPD1 HPX ARFIP2 TIMM10B CAVIN3 APBB1 GC11P006400 PIR40798
GH11H006703 1 ENCODE dbSUPER 11.6 -383.0 -383018 0 ELF3 CTCF NFIB CEBPG RAD21 RFX5 IRF9 ZNF366 HSF1 SMC3 MRPL17 CAVIN3 RRP8 GVINP2 GC11P006694 PIR51504
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAVIN3 on UCSC Golden Path with GeneCards custom track

Promoters for CAVIN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036277 747 1801 GTF2F1 TBP PKNOX1 KLF1 MAX EBF1 RFX5 ZKSCAN1 E2F1 POLR2A

Genomic Location for CAVIN3 Gene

Chromosome:
11
Start:
6,318,946 bp from pter
End:
6,320,647 bp from pter
Size:
1,702 bases
Orientation:
Minus strand

Genomic View for CAVIN3 Gene

Genes around CAVIN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAVIN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAVIN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAVIN3 Gene

Proteins for CAVIN3 Gene

  • Protein details for CAVIN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969G5-CAVN3_HUMAN
    Recommended name:
    Caveolae-associated protein 3
    Protein Accession:
    Q969G5

    Protein attributes for CAVIN3 Gene

    Size:
    261 amino acids
    Molecular mass:
    27701 Da
    Quaternary structure:
    • Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4. Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding. Interacts with PER2. Interacts with CAVIN1 (By similarity). Interacts (via leucine-zipper domain) with CAV1 in a cholesterol-sensitive manner (PubMed:19262564). Interacts with EPS15L1 (PubMed:19262564).

neXtProt entry for CAVIN3 Gene

Post-translational modifications for CAVIN3 Gene

Other Protein References for CAVIN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAVIN3 Gene

Domains & Families for CAVIN3 Gene

Gene Families for CAVIN3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CAVIN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CAVIN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q969G5

UniProtKB/Swiss-Prot:

CAVN3_HUMAN :
  • The leucine-zipper domain is essential for its localization in the caveolae and for its interaction with CAV1 and EPS15L1.
  • Belongs to the CAVIN family.
Domain:
  • The leucine-zipper domain is essential for its localization in the caveolae and for its interaction with CAV1 and EPS15L1.
Family:
  • Belongs to the CAVIN family.
genes like me logo Genes that share domains with CAVIN3: view

Function for CAVIN3 Gene

Molecular function for CAVIN3 Gene

UniProtKB/Swiss-Prot Function:
Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated in breast and lung cancer cell lines.

Phenotypes From GWAS Catalog for CAVIN3 Gene

Gene Ontology (GO) - Molecular Function for CAVIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IBA --
GO:0005515 protein binding IPI 19262564
genes like me logo Genes that share ontologies with CAVIN3: view
genes like me logo Genes that share phenotypes with CAVIN3: view

Animal Models for CAVIN3 Gene

MGI Knock Outs for CAVIN3:

Animal Model Products

CRISPR Products

miRNA for CAVIN3 Gene

miRTarBase miRNAs that target CAVIN3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CAVIN3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAVIN3 Gene

Localization for CAVIN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAVIN3 Gene

Cytoplasm. Membrane, caveola. Cytoplasm, cytosol. Note=Localizes in the caveolae in a caveolin-dependent manner. {ECO:0000269 PubMed:19262564}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAVIN3 gene
Compartment Confidence
plasma membrane 5
cytosol 4
extracellular 2
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAVIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS,IBA --
GO:0005829 cytosol IEA --
GO:0005901 caveola IEA,IDA 19525939
GO:0016020 membrane IEA --
GO:0043234 protein complex IDA 24013648
genes like me logo Genes that share ontologies with CAVIN3: view

Pathways & Interactions for CAVIN3 Gene

genes like me logo Genes that share pathways with CAVIN3: view

Pathways by source for CAVIN3 Gene

1 BioSystems pathway for CAVIN3 Gene
1 PharmGKB pathway for CAVIN3 Gene

Gene Ontology (GO) - Biological Process for CAVIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030866 cortical actin cytoskeleton organization IEA --
GO:0032922 circadian regulation of gene expression ISS,IEA --
GO:0048511 rhythmic process IEA --
GO:0051898 negative regulation of protein kinase B signaling IEA --
GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA --
genes like me logo Genes that share ontologies with CAVIN3: view

No data available for SIGNOR curated interactions for CAVIN3 Gene

Drugs & Compounds for CAVIN3 Gene

(124) Additional Compounds for CAVIN3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with CAVIN3: view

Transcripts for CAVIN3 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CAVIN3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CAVIN3 Gene

No ASD Table

Relevant External Links for CAVIN3 Gene

GeneLoc Exon Structure for
CAVIN3
ECgene alternative splicing isoforms for
CAVIN3

Expression for CAVIN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CAVIN3 Gene:

CAVIN3

mRNA Expression by UniProt/SwissProt for CAVIN3 Gene:

Q969G5-CAVN3_HUMAN
Tissue specificity: Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Strongly expressed in mammary and epithelial cells.

Evidence on tissue expression from TISSUES for CAVIN3 Gene

  • Skin(4.4)
  • Liver(4.1)
  • Lung(2.3)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with CAVIN3: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAVIN3 Gene

Orthologs for CAVIN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAVIN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCDBP 33 34
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia PRKCDBP 33 34
  • 85.66 (n)
rat
(Rattus norvegicus)
Mammalia Prkcdbp 33
  • 84.58 (n)
dog
(Canis familiaris)
Mammalia PRKCDBP 33 34
  • 83.91 (n)
mouse
(Mus musculus)
Mammalia Prkcdbp 33 34
  • 82.94 (n)
Cavin3 16
oppossum
(Monodelphis domestica)
Mammalia PRKCDBP 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKCDBP 34
  • 25 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKCDBP 34
  • 21 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sdprb 34
  • 19 (a)
ManyToMany
sdpra 34
  • 17 (a)
ManyToMany
Species where no ortholog for CAVIN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAVIN3 Gene

ENSEMBL:
Gene Tree for CAVIN3 (if available)
TreeFam:
Gene Tree for CAVIN3 (if available)

Paralogs for CAVIN3 Gene

Paralogs for CAVIN3 Gene

genes like me logo Genes that share paralogs with CAVIN3: view

Variants for CAVIN3 Gene

Sequence variations from dbSNP and Humsavar for CAVIN3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000455180 -- 6,318,939(+) CACGG(A/G)GTCTG downstream-variant-500B, upstream-variant-2KB
rs1001770437 -- 6,318,773(+) GAAAG(G/T)GTTTA downstream-variant-500B, upstream-variant-2KB
rs1001980082 -- 6,319,426(+) CTGGG(C/G)CCTGG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1002599420 -- 6,321,972(+) CATGG(A/G)CCTGA intron-variant, upstream-variant-2KB
rs1003920741 -- 6,318,638(+) TAAGA(A/G)GAAAA downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CAVIN3 Gene

Variant ID Type Subtype PubMed ID
nsv1046738 CNV loss 25217958
nsv519454 CNV loss 19592680

Variation tolerance for CAVIN3 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAVIN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAVIN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAVIN3 Gene

Disorders for CAVIN3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CAVIN3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hereditary spherocytosis
  • congenital spherocytic hemolytic anemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CAVIN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAVIN3
genes like me logo Genes that share disorders with CAVIN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAVIN3 Gene

Publications for CAVIN3 Gene

  1. Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers. (PMID: 11691816) Xu XL … Minna JD (Cancer research 2001) 3 4 22 60
  2. A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvation. (PMID: 9054438) Izumi Y … Ohno S (The Journal of biological chemistry 1997) 2 3 22 60
  3. Frequent inactivation of hSRBC in ovarian cancers by promoter CpG island hypermethylation. (PMID: 20423276) Tong SY … Lee SK (Acta obstetricia et gynecologica Scandinavica 2010) 3 22 60
  4. SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function. (PMID: 19262564) McMahon KA … Anderson RG (The EMBO journal 2009) 3 4 60
  5. Expression of the candidate tumor suppressor gene hSRBC is frequently lost in primary lung cancers with and without DNA methylation. (PMID: 15940253) Zöchbauer-Müller S … Minna JD (Oncogene 2005) 3 22 60

Products for CAVIN3 Gene

Sources for CAVIN3 Gene

Content
Loading form....