Aliases for CAVIN3 Gene
Aliases for CAVIN3 Gene
External Ids for CAVIN3 Gene
- HGNC: 9400
- Entrez Gene: 112464
- Ensembl: ENSG00000170955
- UniProtKB: Q969G5
Previous HGNC Symbols for CAVIN3 Gene
- PRKCDBP
Summaries for CAVIN3 Gene
-
The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for CAVIN3 Gene
CAVIN3 (Caveolae Associated Protein 3) is a Protein Coding gene. Among its related pathways are Circadian rythm related genes and ADP signalling through P2Y purinoceptor 12. An important paralog of this gene is CAVIN2.
UniProtKB/Swiss-Prot for CAVIN3 Gene
-
Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2. Seems to have an immune potentiation function.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAVIN3 Gene
Genomics for CAVIN3 Gene
Regulatory Elements for CAVIN3 Gene
Regulatory Element Products
Genomic Location for CAVIN3 Gene
- Chromosome:
- 11
- Start:
- 6,318,946 bp from pter
- End:
- 6,320,647 bp from pter
- Size:
- 1,702 bases
- Orientation:
- Minus strand
Genomic View for CAVIN3 Gene
- Cytogenetic band:
-
- 11p15.4 by Ensembl
- 11p15.4 by Entrez Gene
- 11p15.4 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CAVIN3 Gene
Proteins for CAVIN3 Gene
-
Protein details for CAVIN3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q969G5-PRDBP_HUMAN
- Recommended name:
- Protein kinase C delta-binding protein
- Protein Accession:
- Q969G5
Protein attributes for CAVIN3 Gene
- Size:
- 261 amino acids
- Molecular mass:
- 27701 Da
- Quaternary structure:
-
- Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding. Interacts with PER2.
Post-translational modifications for CAVIN3 Gene
- In vitro, phosphorylated by PRKCD.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CAVIN3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CAVIN3
-
Custom Antibody ServicesOriGene Antibodies for CAVIN3
- Novus Biologicals Antibodies for CAVIN3
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- antibodies-online Antibodies for CAVIN3: See all 51
- GeneTex PRKCDBP antibody for CAVIN3
-
Custom Antibody ServicesProSci Antibodies for CAVIN3
Protein Products
-
OriGene Purified Proteins for CAVIN3
- Search Origene for MassSpec and Protein Over-expression Lysates for CAVIN3
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- antibodies-online Proteins for CAVIN3: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CAVIN3
Assay Products
- antibodies-online Kits for CAVIN3: See all 4
No data available for DME Specific Peptides for CAVIN3 Gene
Domains & Families for CAVIN3 Gene
Gene Families for CAVIN3 Gene
- HGNC:
Suggested Antigen Peptide Sequences for CAVIN3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q969G5- Family:
-
- Belongs to the PTRF/SDPR family.
Function for CAVIN3 Gene
Molecular function for CAVIN3 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2. Seems to have an immune potentiation function.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated in breast and lung cancer cell lines.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005080 | protein kinase C binding | IBA | -- |
| GO:0005515 | protein binding | IPI | 19262564 |
Phenotypes for CAVIN3 Gene
- MGI mutant phenotypes for CAVIN3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CAVIN3:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for CAVIN3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CAVIN3 gene
- Search ViGene Biosciences for CAVIN3
CRISPR Products
-
OriGene CRISPR knockouts for CAVIN3
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miRNA for CAVIN3 Gene
- miRTarBase miRNAs that target CAVIN3
miRNA Products
- Search ViGene Biosciences for CAVIN3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CAVIN3
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-
ViGene Biosciences ready-to-package AAV shRNAs for CAVIN3 gene
Clone Products
-
OriGene ORF clones in human for CAVIN3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CAVIN3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAVIN3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CAVIN3
-
ViGene Biosciences adenoviral particle packaged cDNA for CAVIN3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CAVIN3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CAVIN3 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAVIN3 Gene
Localization for CAVIN3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CAVIN3 Gene
- Cytoplasm.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA,ISS | -- |
| GO:0005901 | caveola | IDA,IEA | 24013648 |
| GO:0043234 | protein complex | IDA | 24013648 |
Pathways & Interactions for CAVIN3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | ADP signalling through P2Y purinoceptor 12 | ||
| 2 | Circadian rythm related genes | ||
Pathways by source for CAVIN3 Gene
1 BioSystems pathway for CAVIN3 Gene
1 PharmGKB pathway for CAVIN3 Gene
Interacting Proteins for CAVIN3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030866 | cortical actin cytoskeleton organization | IEA | -- |
| GO:0032922 | circadian regulation of gene expression | IEA,ISS | -- |
| GO:0048511 | rhythmic process | IEA | -- |
| GO:0051898 | negative regulation of protein kinase B signaling | IEA | -- |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | IEA | -- |
No data available for SIGNOR curated interactions for CAVIN3 Gene
Drugs & Compounds for CAVIN3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| PS(14:0/14:0) |
|
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| PS(14:0/14:1(9Z)) |
|
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| PS(14:0/16:0) |
|
|
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| PS(14:0/16:1(9Z)) |
|
|
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| PS(14:0/18:0) |
|
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Transcripts for CAVIN3 Gene
mRNA/cDNA for CAVIN3 Gene
- (1) REFSEQ mRNAs :
- (237) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CAVIN3
- GenScript: Design CRISPR guide RNA sequences for CAVIN3
miRNA Products
- Search ViGene Biosciences for CAVIN3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CAVIN3
- Browse OriGene Inhibitory RNA Products For CAVIN3
-
ViGene Biosciences ready-to-package AAV shRNAs for CAVIN3 gene
Clone Products
-
OriGene ORF clones in human for CAVIN3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CAVIN3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAVIN3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CAVIN3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Outflow Tract
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
- Adipose (Muscoskeletal System)
NURSA nuclear receptor signaling pathways regulating expression of CAVIN3 Gene:
CAVIN3mRNA Expression by UniProt/SwissProt for CAVIN3 Gene:
Q969G5-PRDBP_HUMANEvidence on tissue expression from TISSUES for CAVIN3 Gene
- Skin(4.4)
- Liver(4.1)
- Lung(2.3)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for CAVIN3
-
OriGene qPCR primer pairs and template standards for CAVIN3
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAVIN3 Gene
Orthologs for CAVIN3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PRKCDBP 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | PRKCDBP 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Prkcdbp 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PRKCDBP 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Prkcdbp 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PRKCDBP 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PRKCDBP 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PRKCDBP 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | sdprb 35 |
|
ManyToMany | |
| sdpra 35 |
|
ManyToMany |
- Species where no ortholog for CAVIN3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CAVIN3 Gene
Variants for CAVIN3 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000455180 | -- | 6,318,939(+) | CACGG(A/G)GTCTG | downstream-variant-500B, upstream-variant-2KB | |
| rs1001770437 | -- | 6,318,773(+) | GAAAG(G/T)GTTTA | downstream-variant-500B, upstream-variant-2KB | |
| rs1001980082 | -- | 6,319,426(+) | CTGGG(C/G)CCTGG | nc-transcript-variant, upstream-variant-2KB, reference, missense | |
| rs1002599420 | -- | 6,321,972(+) | CATGG(A/G)CCTGA | intron-variant, upstream-variant-2KB | |
| rs1003920741 | -- | 6,318,638(+) | TAAGA(A/G)GAAAA | downstream-variant-500B, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1046738 | CNV | loss | 25217958 |
| nsv519454 | CNV | loss | 19592680 |
Relevant External Links for CAVIN3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CAVIN3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAVIN3 Gene
Disorders for CAVIN3 Gene
Relevant External Links for CAVIN3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CAVIN3
No disorders were found for CAVIN3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAVIN3 Gene
Publications for CAVIN3 Gene
- Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers. (PMID: 11691816) Xu X.L. … Minna J.D. (Cancer Res. 2001) 3 4 22 64
- A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvation. (PMID: 9054438) Izumi Y. … Ohno S. (J. Biol. Chem. 1997) 2 3 22 64
- Frequent inactivation of hSRBC in ovarian cancers by promoter CpG island hypermethylation. (PMID: 20423276) Tong S.Y. … Lee S.K. (Acta Obstet Gynecol Scand 2010) 3 22 64
- Expression of the candidate tumor suppressor gene hSRBC is frequently lost in primary lung cancers with and without DNA methylation. (PMID: 15940253) ZAPchbauer-MA1ller S. … Minna J.D. (Oncogene 2005) 3 22 64
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
Products for CAVIN3 Gene
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- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for CAVIN3
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- OriGene qPCR primer pairs and template standards for CAVIN3
- OriGene qPCR primer pairs for CAVIN3
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- Novus Biologicals Antibodies for CAVIN3
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- antibodies-online Antibodies for CAVIN3: See all 51
- antibodies-online Kits for CAVIN3: See all 4
- antibodies-online Proteins for CAVIN3: See all 7
- Search antibodies-online for peptides
- GeneTex PRKCDBP antibody for CAVIN3
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- ViGene Biosciences adenoviral particle packaged cDNA for CAVIN3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CAVIN3 gene
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- Search ViGene Biosciences for CAVIN3
- Custom Antibody ServicesProSci Antibodies for CAVIN3
- Search for CAVIN3 Proteins at ProSci
- Horizon Cell Lines for CAVIN3
- Cyagen custom Knockout/knockin (KOKI) mouse models for CAVIN3
- VectorBuilder custom plasmid, inducible vectors for CAVIN3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAVIN3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CAVIN3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
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- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer



