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Aliases for CAVIN3 Gene

Aliases for CAVIN3 Gene

  • Caveolae Associated Protein 3 2 3
  • Protein Kinase C Delta Binding Protein 2 3 5
  • PRKCDBP 3 4 5
  • Serum Deprivation Response Factor-Related Gene Product That Binds To C-Kinase 3 4
  • Sdr-Related Gene Product That Binds To C-Kinase 2 3
  • Cavin-3 3 4
  • HSRBC 3 4
  • SRBC 3 4
  • Protein Kinase C, Delta Binding Protein 2
  • Protein Kinase C Delta-Binding Protein 3

External Ids for CAVIN3 Gene

Previous HGNC Symbols for CAVIN3 Gene

  • PRKCDBP

Summaries for CAVIN3 Gene

Entrez Gene Summary for CAVIN3 Gene

  • The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAVIN3 Gene

CAVIN3 (Caveolae Associated Protein 3) is a Protein Coding gene. Among its related pathways are Circadian rythm related genes and ADP signalling through P2Y purinoceptor 12. An important paralog of this gene is CAVIN2.

UniProtKB/Swiss-Prot for CAVIN3 Gene

  • Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2. Seems to have an immune potentiation function.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAVIN3 Gene

Genomics for CAVIN3 Gene

Regulatory Elements for CAVIN3 Gene

Enhancers for CAVIN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G006317 1.2 ENCODE dbSUPER 25.2 -0.3 -258 7.0 TBP PKNOX1 RFX5 RCOR1 FOS RELB ETV6 CREM SMARCC1 CBFB CAVIN3 OR56A1 TAF10 GC11M006313
GH11G006742 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.8 -424.6 -424586 6.5 HDAC1 TBP PKNOX1 CBX3 NFRKB YBX1 TCF12 ZNF766 GATA2 CBX5 RRP8 OR2AG2 CAVIN3 ILK DCHS1 TAF10 ENSG00000254641 OR10A4 APBB1 SMPD1
GH11G006400 1.3 Ensembl ENCODE dbSUPER 9.4 -82.7 -82723 5.5 TBL1XR1 ZBTB40 ZNF766 SCRT2 RELB ETV6 IKZF2 CREM CBFB JUNB SMPD1 HPX TIMM10B ARFIP2 CAVIN3 APBB1 GC11P006400 PIR40798
GH11G006362 1 Ensembl ENCODE 11.9 -42.4 -42367 1.6 SCRT1 CTCF ZNF654 RB1 MAX REST RAD21 RFX5 SMARCA4 KLF16 CAVIN3 SMPD1 APBB1 OR56A1 GC11P006363
GH11G006249 1.1 Ensembl ENCODE 10.4 +70.5 70522 1.1 TBP BRCA1 TCF12 ZNF766 ELK1 GATA2 RCOR1 FOS ZBTB11 USF2 C11orf42 OR52W1 CAVIN3 OR56A1 GC11M006236 CCKBR
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAVIN3 on UCSC Golden Path with GeneCards custom track

Promoters for CAVIN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036277 747 1801 TBP PKNOX1 RFX5 RCOR1 FOS IKZF2 SMARCC1 GATAD2B NR2F2 SMARCA4

Genomic Location for CAVIN3 Gene

Chromosome:
11
Start:
6,318,946 bp from pter
End:
6,320,647 bp from pter
Size:
1,702 bases
Orientation:
Minus strand

Genomic View for CAVIN3 Gene

Genes around CAVIN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAVIN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAVIN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAVIN3 Gene

Proteins for CAVIN3 Gene

  • Protein details for CAVIN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969G5-PRDBP_HUMAN
    Recommended name:
    Protein kinase C delta-binding protein
    Protein Accession:
    Q969G5

    Protein attributes for CAVIN3 Gene

    Size:
    261 amino acids
    Molecular mass:
    27701 Da
    Quaternary structure:
    • Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding. Interacts with PER2.

neXtProt entry for CAVIN3 Gene

Post-translational modifications for CAVIN3 Gene

Other Protein References for CAVIN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAVIN3 Gene

Domains & Families for CAVIN3 Gene

Gene Families for CAVIN3 Gene

Protein Domains for CAVIN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CAVIN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q969G5

UniProtKB/Swiss-Prot:

PRDBP_HUMAN :
  • Belongs to the PTRF/SDPR family.
Family:
  • Belongs to the PTRF/SDPR family.
genes like me logo Genes that share domains with CAVIN3: view

Function for CAVIN3 Gene

Molecular function for CAVIN3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2. Seems to have an immune potentiation function.
UniProtKB/Swiss-Prot Induction:
Down-regulated in breast and lung cancer cell lines.

Gene Ontology (GO) - Molecular Function for CAVIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IBA --
GO:0005515 protein binding IPI 19262564
genes like me logo Genes that share ontologies with CAVIN3: view
genes like me logo Genes that share phenotypes with CAVIN3: view

Animal Models for CAVIN3 Gene

MGI Knock Outs for CAVIN3:

Animal Model Products

CRISPR Products

miRNA for CAVIN3 Gene

miRTarBase miRNAs that target CAVIN3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAVIN3 Gene

Localization for CAVIN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAVIN3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAVIN3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CAVIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,ISS --
GO:0005901 caveola IDA,IEA 24013648
GO:0043234 protein complex IDA 24013648
genes like me logo Genes that share ontologies with CAVIN3: view

Pathways & Interactions for CAVIN3 Gene

genes like me logo Genes that share pathways with CAVIN3: view

Pathways by source for CAVIN3 Gene

1 BioSystems pathway for CAVIN3 Gene
1 PharmGKB pathway for CAVIN3 Gene

Gene Ontology (GO) - Biological Process for CAVIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030866 cortical actin cytoskeleton organization IEA --
GO:0032922 circadian regulation of gene expression IEA,ISS --
GO:0048511 rhythmic process IEA --
GO:0051898 negative regulation of protein kinase B signaling IEA --
GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA --
genes like me logo Genes that share ontologies with CAVIN3: view

No data available for SIGNOR curated interactions for CAVIN3 Gene

Drugs & Compounds for CAVIN3 Gene

(124) Additional Compounds for CAVIN3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with CAVIN3: view

Transcripts for CAVIN3 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAVIN3 Gene

No ASD Table

Relevant External Links for CAVIN3 Gene

GeneLoc Exon Structure for
CAVIN3
ECgene alternative splicing isoforms for
CAVIN3

Expression for CAVIN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CAVIN3 Gene:

CAVIN3

mRNA Expression by UniProt/SwissProt for CAVIN3 Gene:

Q969G5-PRDBP_HUMAN
Tissue specificity: Strongly expressed in mammary and epithelial cells.

Evidence on tissue expression from TISSUES for CAVIN3 Gene

  • Skin(4.4)
  • Liver(4.1)
  • Lung(2.3)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with CAVIN3: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAVIN3 Gene

Orthologs for CAVIN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAVIN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCDBP 35 34
  • 99.74 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRKCDBP 35 34
  • 85.66 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkcdbp 34
  • 84.58 (n)
dog
(Canis familiaris)
Mammalia PRKCDBP 35 34
  • 83.91 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Prkcdbp 35 16 34
  • 82.94 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKCDBP 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKCDBP 35
  • 25 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKCDBP 35
  • 21 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sdprb 35
  • 19 (a)
ManyToMany
sdpra 35
  • 17 (a)
ManyToMany
Species where no ortholog for CAVIN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAVIN3 Gene

ENSEMBL:
Gene Tree for CAVIN3 (if available)
TreeFam:
Gene Tree for CAVIN3 (if available)

Paralogs for CAVIN3 Gene

Paralogs for CAVIN3 Gene

genes like me logo Genes that share paralogs with CAVIN3: view

Variants for CAVIN3 Gene

Sequence variations from dbSNP and Humsavar for CAVIN3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000455180 -- 6,318,939(+) CACGG(A/G)GTCTG downstream-variant-500B, upstream-variant-2KB
rs1001770437 -- 6,318,773(+) GAAAG(G/T)GTTTA downstream-variant-500B, upstream-variant-2KB
rs1001980082 -- 6,319,426(+) CTGGG(C/G)CCTGG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1002599420 -- 6,321,972(+) CATGG(A/G)CCTGA intron-variant, upstream-variant-2KB
rs1003920741 -- 6,318,638(+) TAAGA(A/G)GAAAA downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CAVIN3 Gene

Variant ID Type Subtype PubMed ID
nsv1046738 CNV loss 25217958
nsv519454 CNV loss 19592680

Variation tolerance for CAVIN3 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAVIN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAVIN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAVIN3 Gene

Disorders for CAVIN3 Gene

Relevant External Links for CAVIN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAVIN3

No disorders were found for CAVIN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAVIN3 Gene

Publications for CAVIN3 Gene

  1. Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers. (PMID: 11691816) Xu X.L. … Minna J.D. (Cancer Res. 2001) 3 4 22 64
  2. A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvation. (PMID: 9054438) Izumi Y. … Ohno S. (J. Biol. Chem. 1997) 2 3 22 64
  3. Frequent inactivation of hSRBC in ovarian cancers by promoter CpG island hypermethylation. (PMID: 20423276) Tong S.Y. … Lee S.K. (Acta Obstet Gynecol Scand 2010) 3 22 64
  4. Expression of the candidate tumor suppressor gene hSRBC is frequently lost in primary lung cancers with and without DNA methylation. (PMID: 15940253) ZAPchbauer-MA1ller S. … Minna J.D. (Oncogene 2005) 3 22 64
  5. Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae. (PMID: 25588833) Mohan J. … Lundmark R. (J. Cell. Sci. 2015) 3 64

Products for CAVIN3 Gene

Sources for CAVIN3 Gene

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