Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CAVIN2 Gene

Aliases for CAVIN2 Gene

  • Caveolae Associated Protein 2 2 3 5
  • Phosphatidylserine-Binding Protein 3 4
  • Serum Deprivation-Response Protein 3 4
  • Serum Deprivation Response 2 3
  • Cavin-2 3 4
  • PS-P68 3 4
  • SDPR 3 4
  • Serum Deprivation Response (Phosphatidylserine-Binding Protein) 2
  • Serum Deprivation Response (Phosphatidylserine Binding Protein) 2
  • Phosphatidylserine Binding Protein 2
  • Caveolae-Associated Protein 2 3
  • SDR 3

External Ids for CAVIN2 Gene

Previous HGNC Symbols for CAVIN2 Gene

  • SDPR

Summaries for CAVIN2 Gene

Entrez Gene Summary for CAVIN2 Gene

  • This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009]

GeneCards Summary for CAVIN2 Gene

CAVIN2 (Caveolae Associated Protein 2) is a Protein Coding gene. An important paralog of this gene is CAVIN1.

UniProtKB/Swiss-Prot for CAVIN2 Gene

  • Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity).

Gene Wiki entry for CAVIN2 Gene

Additional gene information for CAVIN2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAVIN2 Gene

Genomics for CAVIN2 Gene

Regulatory Elements for CAVIN2 Gene

Enhancers for CAVIN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H191843 1.5 FANTOM5 ENCODE dbSUPER 51.2 +1.4 1433 5 PKNOX1 FOXA2 ATF1 MLX ZFP64 ARID4B SIN3A SLC30A9 GATA2 ATF7 CAVIN2 LOC105373813 GC02P191798
GH02H191909 1.3 FANTOM5 Ensembl ENCODE dbSUPER 38.3 -63.3 -63254 1 JUND JUN MAFK CAVIN2 LOC105373813 NABP1 DNAJB1P1 GC02P192046
GH02H191849 0.8 FANTOM5 dbSUPER 37.7 -2.3 -2298 0 SOX6 FOXK2 MNT ATF7 CAVIN2 DNAJB1P1
GH02H191950 1.8 ENCODE 11 -103.2 -103246 0 BACH1 BATF CHAMP1 FOSL1 CC2D1A ZNF316 NCOR1 FOS NFE2 TRIM24 CAVIN2 LOC105373813 DNAJB1P1 GC02P192046
GH02H191674 1.8 FANTOM5 ENCODE dbSUPER 10.5 +168.2 168237 8 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 NABP1 LOC105373813 CAVIN2 STAT1 GC02P191680
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAVIN2 on UCSC Golden Path with GeneCards custom track

Promoters for CAVIN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000128090 1580 3801 PKNOX1 FOXA2 MLX ZFP64 ARID4B SLC30A9 GATA2 ATF7 SP5 NFYC

Genomic Location for CAVIN2 Gene

Chromosome:
2
Start:
191,834,302 bp from pter
End:
191,847,280 bp from pter
Size:
12,979 bases
Orientation:
Minus strand

Genomic View for CAVIN2 Gene

Genes around CAVIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAVIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAVIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAVIN2 Gene

Proteins for CAVIN2 Gene

  • Protein details for CAVIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95810-CAVN2_HUMAN
    Recommended name:
    Caveolae-associated protein 2
    Protein Accession:
    O95810

    Protein attributes for CAVIN2 Gene

    Size:
    425 amino acids
    Molecular mass:
    47173 Da
    Quaternary structure:
    • Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4. Binds to PRKCA in the presence of phosphatidylserine (By similarity). Interacts with CAVIN4; this augments the transactivation of NPPA by CAVIN4 (PubMed:18332105, PubMed:24567387). Interacts with CAVIN1 (PubMed:19525939, PubMed:24567387). Interacts with CAV3 (PubMed:24567387).
    Miscellaneous:
    • Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine.

neXtProt entry for CAVIN2 Gene

Post-translational modifications for CAVIN2 Gene

Other Protein References for CAVIN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CAVIN2

No data available for DME Specific Peptides for CAVIN2 Gene

Domains & Families for CAVIN2 Gene

Gene Families for CAVIN2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CAVIN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CAVIN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95810

UniProtKB/Swiss-Prot:

CAVN2_HUMAN :
  • The leucine-zipper domain is essential for its localization in the caveolae.
  • Belongs to the CAVIN family.
Domain:
  • The leucine-zipper domain is essential for its localization in the caveolae.
Family:
  • Belongs to the CAVIN family.
genes like me logo Genes that share domains with CAVIN2: view

Function for CAVIN2 Gene

Molecular function for CAVIN2 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated in asyncronously growing fibroblasts following serum deprivation but not following contact inhibition. Down-regulated during synchronous cell cycle re-entry.

Phenotypes From GWAS Catalog for CAVIN2 Gene

Gene Ontology (GO) - Molecular Function for CAVIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IDA 2390065
GO:0005080 protein kinase C binding IBA --
GO:0005515 protein binding IPI 19525939
GO:0005543 phospholipid binding TAS 10191091
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with CAVIN2: view
genes like me logo Genes that share phenotypes with CAVIN2: view

Animal Models for CAVIN2 Gene

MGI Knock Outs for CAVIN2:

Animal Model Products

CRISPR Products

miRNA for CAVIN2 Gene

miRTarBase miRNAs that target CAVIN2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CAVIN2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAVIN2 Gene

Localization for CAVIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAVIN2 Gene

Cytoplasm, cytosol. Membrane, caveola. Note=Localizes in the caveolae in a caveolin-dependent manner. {ECO:0000269 PubMed:19262564}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAVIN2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 3
mitochondrion 2
golgi apparatus 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAVIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18332105
GO:0005829 cytosol IDA,IEA 2390065
GO:0005901 caveola IDA,IBA 19525939
GO:0016020 membrane IEA --
GO:0045121 membrane raft IDA 25204797
genes like me logo Genes that share ontologies with CAVIN2: view

Pathways & Interactions for CAVIN2 Gene

SuperPathways for CAVIN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAVIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097320 plasma membrane tubulation IDA 19525939
genes like me logo Genes that share ontologies with CAVIN2: view

No data available for Pathways by source and SIGNOR curated interactions for CAVIN2 Gene

Drugs & Compounds for CAVIN2 Gene

(1) Drugs for CAVIN2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(503) Additional Compounds for CAVIN2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
PI(16:0/16:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
PI(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
  • PI(16:0/18:0)
genes like me logo Genes that share compounds with CAVIN2: view

Transcripts for CAVIN2 Gene

mRNA/cDNA for CAVIN2 Gene

(1) REFSEQ mRNAs :
(140) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CAVIN2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CAVIN2 Gene

No ASD Table

Relevant External Links for CAVIN2 Gene

GeneLoc Exon Structure for
CAVIN2
ECgene alternative splicing isoforms for
CAVIN2

Expression for CAVIN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CAVIN2 Gene:

CAVIN2

mRNA Expression by UniProt/SwissProt for CAVIN2 Gene:

O95810-CAVN2_HUMAN
Tissue specificity: Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.

Evidence on tissue expression from TISSUES for CAVIN2 Gene

  • Blood(4.5)
  • Liver(4.5)
  • Lung(2.7)
  • Spleen(2.6)
  • Heart(2.5)
  • Nervous system(2.4)
  • Muscle(2.3)
  • Intestine(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with CAVIN2: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAVIN2 Gene

Orthologs for CAVIN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAVIN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDPR 33 34
  • 99.53 (n)
cow
(Bos Taurus)
Mammalia SDPR 33 34
  • 86.4 (n)
mouse
(Mus musculus)
Mammalia Sdpr 33 34
  • 82.93 (n)
Cavin2 16
rat
(Rattus norvegicus)
Mammalia Sdpr 33
  • 82.49 (n)
dog
(Canis familiaris)
Mammalia SDPR 34
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SDPR 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves SDPR 33
  • 66.13 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495531 33
  • 67.87 (n)
zebrafish
(Danio rerio)
Actinopterygii sdprb 33 34
  • 66.44 (n)
sdpra 34
  • 36 (a)
ManyToMany
Species where no ortholog for CAVIN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAVIN2 Gene

ENSEMBL:
Gene Tree for CAVIN2 (if available)
TreeFam:
Gene Tree for CAVIN2 (if available)

Paralogs for CAVIN2 Gene

Paralogs for CAVIN2 Gene

genes like me logo Genes that share paralogs with CAVIN2: view

Variants for CAVIN2 Gene

Sequence variations from dbSNP and Humsavar for CAVIN2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000069773 -- 191,837,840(+) TGTGT(A/G)GCCAG intron-variant
rs1000907747 -- 191,844,918(+) TTTGC(C/T)TGATT intron-variant
rs1000966527 -- 191,837,240(+) GAGTC(A/T)GAAGT intron-variant
rs1001256533 -- 191,844,460(+) TGCCT(C/G)TAGTT intron-variant
rs1001692417 -- 191,839,158(+) ATCAG(A/T)GAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAVIN2 Gene

Variant ID Type Subtype PubMed ID
nsv584068 CNV loss 21841781
nsv834494 CNV gain 17160897

Variation tolerance for CAVIN2 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAVIN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAVIN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAVIN2 Gene

Disorders for CAVIN2 Gene

Relevant External Links for CAVIN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAVIN2

No disorders were found for CAVIN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAVIN2 Gene

Publications for CAVIN2 Gene

  1. The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein. (PMID: 10191091) Gustincich S … Schneider C (Genomics 1999) 2 3 4 22 60
  2. Purification and characterization of a major phosphatidylserine-binding phosphoprotein from human platelets. (PMID: 2390065) Burgener R … Baggiolini M (The Biochemical journal 1990) 3 4 22 60
  3. MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors. (PMID: 24567387) Ogata T … Ueyama T (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 4 60
  4. SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function. (PMID: 19262564) McMahon KA … Anderson RG (The EMBO journal 2009) 3 4 60
  5. SDPR induces membrane curvature and functions in the formation of caveolae. (PMID: 19525939) Hansen CG … Nichols BJ (Nature cell biology 2009) 3 4 60

Products for CAVIN2 Gene

Sources for CAVIN2 Gene

Content
Loading form....