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CAV2 Gene

protein-coding   GIFtS: 68
GCID: GC07P115926

Caveolin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Caveolin 21 2
CAV2
Caveolae Protein, 20-KD2
Caveolin 2 Isoform A And B2
caveolin-22

External Ids:    HGNC: 15281   Entrez Gene: 8582   Ensembl: ENSG000001059717   OMIM: 6010485   UniProtKB: P516363   
ORGUL members:         

Export aliases for CAV2 gene to outside databases

Previous GC identifers: GC07P114617 GC07P115680 GC07P115694 GC07P115693 GC07P115733 GC07P110505


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CAV2 Gene:
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the
plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid
metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and
related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins
that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different
isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame
translation initiation codons have also been described, and shown to have preferential localization in the cell
(PMID:11238462). (provided by RefSeq, May 2011)

GeneCards Summary for CAV2 Gene:
CAV2 (caveolin 2) is a protein-coding gene. Diseases associated with CAV2 include splenic marginal zone lymphoma, and hepatopulmonary syndrome. GO annotations related to this gene include phosphoprotein binding and protein homodimerization activity. An important paralog of this gene is CAV1.

UniProtKB/Swiss-Prot: CAV2_HUMAN, P51636
Function: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha
subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in
targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating
mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required
for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation
of cell cycle progression (By similarity)

Gene Wiki entry for CAV2 (Caveolin 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAV2 gene promoter:
         E2F-4   E2F-3a   E2F-5   ATF-2   E2F-2   C/EBPalpha   E2F   E2F-1   c-Jun   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CAV2 promoter sequence
   Search Chromatin IP Primers for CAV2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAV2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.1   Ensembl cytogenetic band:  7q31.2   HGNC cytogenetic band: 7q31

CAV2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAV2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P115926:  view genomic region     (about GC identifiers)

Start:
115,927,434 bp from pter      End:
116,148,595 bp from pter
Size:
221,162 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 115,535,087-115,544,028     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAV2_HUMAN, P51636 (See protein sequence)
Recommended Name: Caveolin-2  
Size: 162 amino acids; 18291 Da
Subunit: Monomer or homodimer. Interacts with CAV1; the interaction forms a stable heterooligomeric complex that
is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form
heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a
monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and
SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is
increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the
interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the
interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity)
Secondary accessions: A4D0U2 Q9UGM7
Alternative initiation: 3 isoforms:  P51636-1   P51636-2   P51636-3   (Produced by alternative splicing)

Explore the universe of human proteins at neXtProt for CAV2: NX_P51636

Explore proteomics data for CAV2 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the
    complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis
    in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced
    'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced
    phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin
    (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CAV2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001193676.1  NP_001193677.1  NP_001224.1  NP_937855.1  

    ENSEMBL proteins: 
     ENSP00000222693   ENSP00000345679   ENSP00000377120  

    CAV2 Human Recombinant Protein Products:

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    OriGene Purified Proteins for CAV2
    OriGene Protein Over-expression Lysate for CAV2
    OriGene MassSpec for CAV2
    OriGene Custom Protein Services for CAV2
    GenScript Custom Purified and Recombinant Proteins Services for CAV2
    Novus Biologicals CAV2 Protein
    Novus Biologicals CAV2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CAV2

    CAV2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CAV2 (Caveolin-2)
    Cell Signaling Technology (CST) Antibodies for CAV2  (caveolin-2)
    OriGene Antibodies for CAV2
    OriGene Custom Antibody Services for CAV2
    Novus Biologicals CAV2 Antibodies
    Abcam antibodies for CAV2
    Cloud-Clone Corp. Antibodies for CAV2
    ThermoFisher Antibody for CAV2
    LSBio Antibodies in human, mouse, rat for CAV2

    CAV2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CAV2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CAV2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CAV2
    Cloud-Clone Corp. CLIAs for CAV2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001612 Caveolin
     IPR018361 Caveolin_CS

    Graphical View of Domain Structure for InterPro Entry P51636

    ProtoNet protein and cluster: P51636

    1 Blocks protein domain: IPB001612 Caveolin

    UniProtKB/Swiss-Prot: CAV2_HUMAN, P51636
    Similarity: Belongs to the caveolin family


    CAV2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAV2_HUMAN, P51636
    Function: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha
    subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in
    targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating
    mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required
    for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation
    of cell cycle progression (By similarity)

         Genatlas biochemistry entry for CAV2:
    caveolin,major component of the inner surface of caveolae,small invaginations of the plasma membrane,expressed in
    brain endothelial and astroglial cells,localized to the Golgi complex,colocalizing and forming a stable
    hetero-oligomeric complex with CAV1,involved in essential cellular functions,including signal transduction,lipid
    metabolism,cellular growth control and apoptosis

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding ----
    GO:0005515protein binding IPI11294831
    GO:0019905syntaxin binding IEA--
    GO:0031748D1 dopamine receptor binding IPI15569306
    GO:0042803protein homodimerization activity IDA8552590
         
    CAV2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CAV2:
     Decreased Tat-dependent transc  Decreased focal adhesion (FA)   Decreased p24 protein expressi  Increased Salmonella enterica  

         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cav2):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  muscle  other  respiratory system 

    CAV2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cav2tm1Mls for CAV2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAV2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAV2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAV2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAV2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CAV2:
    hsa-mir-26b-5p (MIRT029751), hsa-mir-93-5p (MIRT028136), hsa-mir-199a-3p (MIRT006655)

    Block miRNA regulation of human, mouse, rat CAV2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAV2 (see all 34):
    hsa-miR-142-5p hsa-miR-549 hsa-miR-199a-3p hsa-miR-29a hsa-miR-301a hsa-miR-133a hsa-miR-192* hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidCAV2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CAV2
    Predesigned siRNA for gene silencing in human, mouse, rat CAV2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CAV2

    Clone
    Products:
         
    OriGene clones in human, mouse for CAV2 (see all 11)
    OriGene ORF clones in mouse, rat for CAV2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CAV2 (NM_001233)
    Sino Biological Human cDNA Clone for CAV2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAV2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAV2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CAV2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CAV2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAV2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAV2_HUMAN, P51636: Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane;
    Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like
    structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of
    cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By
    similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated
    Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular
    compartments
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    nucleus5
    plasma membrane5
    cytosol2
    cytoskeleton1
    endosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0002080acrosomal membrane IEA--
    GO:0005622intracellular IDA15703204
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----

    CAV2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAV2 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    2Development EGFR signaling pathway
    EGF Pathway0.39
    3Endocytic Trafficking of EGFR
    Cholesterol and Sphingolipids transport Influx to the early endosome in lung normal and CF 0.35
    4Syndecan-2-mediated signaling events
    Syndecan-2-mediated signaling events
    5Remodeling of Adherens Junctions
    Remodeling of Adherens Junctions

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CAV2
        Remodeling of Adherens Junctions
    EGF Pathway

    1 Cell Signaling Technology (CST) Pathway for CAV2
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for CAV2
        Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF)

    4 BioSystems Pathways for CAV2
        Focal Adhesion
    Integrin-mediated cell adhesion
    EGFR1 Signaling Pathway
    Syndecan-2-mediated signaling events



    4 Kegg Pathways  (Kegg details for CAV2):
        Endocytosis
    Focal adhesion
    Bacterial invasion of epithelial cells
    Proteoglycans in cancer


    CAV2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CAV2: 
              Mitochondria in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Prostate Cancer in human mouse rat
              Focal Adhesions in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CAV2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for CAV2 (P516362, 3 ENSP000002226934) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOLGB1Q147892, 3, ENSP000003418484MINT-64180 I2D: score=4 STRING: ENSP00000341848
    DNAJA1P316892, 3, ENSP000003691274MINT-8250679 I2D: score=2 STRING: ENSP00000369127
    CAV1Q031353, ENSP000003391914I2D: score=3 STRING: ENSP00000339191
    RASA1P209363, ENSP000002743764I2D: score=2 STRING: ENSP00000274376
    MALLQ130213, ENSP000002724624I2D: score=1 STRING: ENSP00000272462
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001937negative regulation of endothelial cell proliferation ISS--
    GO:0001938positive regulation of endothelial cell proliferation IEA--
    GO:0006906vesicle fusion IDA12743374
    GO:0007005mitochondrion organization ISS--
    GO:0007029endoplasmic reticulum organization ISS--

    CAV2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAV2

    Selected Novoseek inferred chemical compound relationships for CAV2 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholesterol 38 12 11907140 (2), 12730355 (1), 12867544 (1), 17303668 (1) (see all 7)
    lipid 34.1 22 12867544 (3), 18081315 (3), 17303668 (2), 12730355 (1) (see all 12)
    tyrosine 28.6 11 15504032 (7), 19895792 (1), 15545264 (1), 12091389 (1)
    sucrose 17.8 2 10600487 (1), 18081315 (1)
    dihydrotestosterone 14.7 1 14576147 (1)
    atp 0 1 11278795 (1)
    nitric oxide 0 2 18717816 (1)
    glucose 0 1 16803459 (1)
    fatty acid 0 3 11278795 (1), 16803459 (1)
    alanine 0 3 15504032 (2), 19778377 (1)



    CAV2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CAV2 gene (4 alternative transcripts): 
    NM_001206747.1  NM_001206748.1  NM_001233.4  NM_198212.2  

    Unigene Cluster for CAV2:

    Caveolin 2
    Hs.212332  [show with all ESTs]
    Unigene Representative Sequence: NM_001233
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490906 ENST00000460222 ENST00000477018(uc003vhv.2) ENST00000467035(uc003vhw.2)
    ENST00000484871(uc010lkc.2) ENST00000485561(uc010lkb.1) ENST00000472470(uc003vhx.2)
    ENST00000498493(uc003via.2) ENST00000478226(uc003vib.2) ENST00000462876(uc003vhz.2)
    ENST00000465451 ENST00000222693(uc003vid.3 uc003vie.3 uc022akj.1)
    ENST00000343213 ENST00000393480 ENST00000495841
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CAV2 (see all 34):
    hsa-miR-142-5p hsa-miR-549 hsa-miR-199a-3p hsa-miR-29a hsa-miR-301a hsa-miR-133a hsa-miR-192* hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidCAV2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CAV2
    Predesigned siRNA for gene silencing in human, mouse, rat CAV2
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): CAV2 (NM_001233)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAV2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAV2
    Primer
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    OriGene qPCR primer pairs and template standards for CAV2
    OriGene qSTAR qPCR primer pairs in human, mouse for CAV2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAV2
      QuantiTect SYBR Green Assays in human, mouse, rat CAV2
      QuantiFast Probe-based Assays in human, mouse, rat CAV2

    Additional mRNA sequence: 

    AB451285.1 AB451417.1 AF035752.1 AK024513.1 AK310786.1 AK311964.1 AY353255.1 BC005256.1 
    BT007051.1 CR407685.1 DQ656010.2 DQ656011.2 DQ656012.2 DQ656014.2 DQ656016.2 DQ656017.2 
    DQ656068.1 DQ656069.1 EF070113.1 EF070114.1 EF070115.1 EF070120.1 

    15 DOTS entries:

    DT.455952  DT.92438097  DT.100791767  DT.95194984  DT.99941296  DT.121641096  DT.97777809  DT.100791766 
    DT.95285530  DT.99931724  DT.100791770  DT.121091609  DT.99988109  DT.121091577  DT.92438094 

    Selected AceView cDNA sequences (see all 188):

    BE677215 CD516968 BM838686 CR604437 AY353255 AA486567 CD514571 BU687757 
    AA367026 NM_198212 BM840492 AA345513 AA344857 BM848465 CF127914 BG777119 
    BM760304 CR407685 AA878149 NM_001233 AI864109 BM841156 AU137817 BE856580 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CAV2    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d
    SP1:        -     -           -                                 
    SP2:                          -                                 
    SP3:                          -     -                           
    SP4:                                                            


    ECgene alternative splicing isoforms for CAV2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CAV2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTTGTTT
    CAV2 Expression
    About this image


    CAV2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
             Oligodendrocyte-like cells
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CAV2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAV2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.212332

    UniProtKB/Swiss-Prot: CAV2_HUMAN, P51636
    Tissue specificity: Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts

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              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CAV2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cav21 , 5 caveolin 21, 5 86.63(n)1
    90.12(a)1
      6 (7.72 cM)5
    123901  NM_016900.41  NP_058596.11 
     172811855 
    chicken
    (Gallus gallus)
    Aves CAV21 caveolin 2 73.71(n)
    66.46(a)
      417772  NM_001007086.1  NP_001007087.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAV26
    caveolin 2
    60(a)
    1 ↔ 1
    5(60951470-60970122)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.33972 Xenopus laevis transcribed sequence with weak similarity more 74.79(n)    BJ067198.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cav21 caveolin 2 57.14(n)
    50.93(a)
      415240  NM_001002150.1  NP_001002150.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cav-26
    Protein CAV-2, isoform a
    13(a)
    1 ↔ 1
    V(13557160-13559922) WBGene00000302


    ENSEMBL Gene Tree for CAV2 (if available)
    TreeFam Gene Tree for CAV2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAV2 gene
    CAV12  CAV32  
    3 SIMAP similar genes for CAV2 using alignment to 3 protein entries:     CAV2_HUMAN (see all proteins):
    caveolin-2    CAV1    CAV3

    CAV2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAV2 (see all 283)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1998124461,2
    --115535940(+) GAGACA/GGGGCA 4 -- int10--------
    rs345451791,2
    C--115537963(+) TTAGCT/-TATGC 4 -- int11Minor allele frequency- -:0.50NA 2
    rs353007991,2
    C--115539085(+) AAGCT-/GGGCAG 4 -- int11Minor allele frequency- G:0.00NA 2
    rs717735821,2
    C--115539538(+) GAAAG-/AGAA  
            
    AGAAA
    4 -- int11Minor allele frequency- AGAA:0.00CSA 2
    rs30308041,2
    C--116138977(+) ACACAC/AACACA 4 -- us2k13Minor allele frequency- A:0.20NA CSA 5
    rs559603841,2
    C--116139017(+) AAAAAA/-TCAGA 4 -- us2k11Minor allele frequency- -:0.00NA 2
    rs32143171,2
    C--116140509(+) GAGACG/-GGGCA 4 -- int11Minor allele frequency- -:0.00NA 2
    rs577211161,2
    C--116144093(+) AAAGA-/AAGA  
            
    GAAAG
    4 -- int10--------
    rs171387671,2
    C,F,H--119489110(+) TTTTTA/GCCCAC 3 -- us2k116Minor allele frequency- G:0.11NA NS EA 1226
    rs1143241891,2
    C,F--119489134(+) TCTTGT/CACTAG 3 -- us2k11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for CAV2 (115927434 - 116148595 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CAV2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831106CNV Gain17160897
    nsv7405OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CAV2
    DNA2.0 Custom Variant and Variant Library Synthesis for CAV2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601048    OMIM disorders: --

    Selected diseases for CAV2 (see all 49):    
    About MalaCards
    splenic marginal zone lymphoma    hepatopulmonary syndrome    cerebral amyloid angiopathy    primary open angle glaucoma
    parathyroid adenoma    open-angle glaucoma    rabies    primary biliary cirrhosis
    glaucoma    conjunctivitis    thyroid cancer    colon adenocarcinoma
    fibrosarcoma    ulcerative colitis    esophageal squamous cell carcinoma    bronchiolitis
    adenoma    muscular dystrophy    cerebritis    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for CAV2:
    Rabies

    CAV2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CAV2 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 17.2 21 12866378 (4), 9662443 (2), 12620387 (2), 15252854 (2) (see all 10)
    adenocarcinoma 10.2 3 15095482 (1), 15069532 (1), 11345836 (1)
    prostate cancer 2.9 2 12743374 (1)
    adenoma 2.04 3 11345836 (2), 12970324 (1)
    colon cancer 1.66 2 12414992 (1)
    carcinoma squamous cell 0 2 17671707 (2)
    necrosis 0 1 11278795 (1)
    breast cancer 0 15 15305200 (6), 17912630 (3), 18612310 (3)
    metastasis 0 1 16207479 (1)
    bladder cancer 0 1 16909110 (1)

    Genetic Association Database (GAD): CAV2
    Human Genome Epidemiology (HuGE) Navigator: CAV2 (12 documents)

    Export disorders for CAV2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAV2 gene, integrated from 10 sources (see all 196):
    (articles sorted by number of sources associating them with CAV2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. (PubMed id 8552590)1, 2, 3, 9 Scherer P.E....Lisanti M.P. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27). (PubMed id 15504032)1, 2, 9 Wang X.B.... Lisanti M.P. (Biochemistry 2004)
    3. Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho- caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. (PubMed id 12091389)1, 2, 9 Lee H....Lisanti M.P. (J. Biol. Chem. 2002)
    4. Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells. (PubMed id 18081315)1, 2, 9 Sowa G.... Sessa W.C. (Biochemistry 2008)
    5. Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo. (PubMed id 9361015)1, 2, 9 Scherer P.E.... Lisanti M.P. (J. Biol. Chem. 1997)
    6. Analysis of candidate genes for prostate cancer. (PubMed id 15583422)1, 4, 9 Burmester J.K....Catalona W.J. (Hum. Hered. 2004)
    7. Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors. (PubMed id 10087206)1, 3, 9 Fra A.M.... Sitia R. (Genomics 1999)
    8. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (Gastroenterology 2010)
    9. Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma. (PubMed id 20835238)1, 4 Thorleifsson G....Stefansson K. (Nat. Genet. 2010)
    10. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 858 HGNC: 1528 AceView: CAV2 Ensembl:ENSG00000105971 euGenes: HUgn858
    ECgene: CAV2 Kegg: 858 H-InvDB: CAV2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CAV2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CAV2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Caveolin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAV2 gene:
    Search GeneIP for patents involving CAV2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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