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Aliases for CAV2 Gene

Aliases for CAV2 Gene

  • Caveolin 2 2 3 5
  • Caveolin 2 Isoform A And B 3
  • Caveolae Protein, 20-KD 3
  • CAV 3

External Ids for CAV2 Gene

Previous GeneCards Identifiers for CAV2 Gene

  • GC07P114617
  • GC07P115680
  • GC07P115694
  • GC07P115693
  • GC07P115733
  • GC07P115926
  • GC07P110505

Summaries for CAV2 Gene

Entrez Gene Summary for CAV2 Gene

  • The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]

GeneCards Summary for CAV2 Gene

CAV2 (Caveolin 2) is a Protein Coding gene. Diseases associated with CAV2 include open-angle glaucoma and glaucoma 1, open angle, e. Among its related pathways are Bacterial invasion of epithelial cells and Endocytosis. GO annotations related to this gene include protein homodimerization activity and D1 dopamine receptor binding. An important paralog of this gene is CAV1.

UniProtKB/Swiss-Prot for CAV2 Gene

  • May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).

Gene Wiki entry for CAV2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAV2 Gene

Genomics for CAV2 Gene

Regulatory Elements for CAV2 Gene

Enhancers for CAV2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAV2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAV2 Gene

Chromosome:
7
Start:
116,287,380 bp from pter
End:
116,508,541 bp from pter
Size:
221,162 bases
Orientation:
Plus strand

Genomic View for CAV2 Gene

Genes around CAV2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAV2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAV2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAV2 Gene

Proteins for CAV2 Gene

  • Protein details for CAV2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51636-CAV2_HUMAN
    Recommended name:
    Caveolin-2
    Protein Accession:
    P51636
    Secondary Accessions:
    • A4D0U2
    • Q9UGM7

    Protein attributes for CAV2 Gene

    Size:
    162 amino acids
    Molecular mass:
    18291 Da
    Quaternary structure:
    • Monomer or homodimer. Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).

    Alternative splice isoforms for CAV2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAV2 Gene

Proteomics data for CAV2 Gene at MOPED

Post-translational modifications for CAV2 Gene

  • Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced Ser-727 phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAV2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CAV2 (Caveolin-2)

No data available for DME Specific Peptides for CAV2 Gene

Domains & Families for CAV2 Gene

Protein Domains for CAV2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CAV2 Gene

Graphical View of Domain Structure for InterPro Entry

P51636

UniProtKB/Swiss-Prot:

CAV2_HUMAN :
  • Belongs to the caveolin family.
Family:
  • Belongs to the caveolin family.
genes like me logo Genes that share domains with CAV2: view

No data available for Gene Families for CAV2 Gene

Function for CAV2 Gene

Molecular function for CAV2 Gene

GENATLAS Biochemistry:
caveolin,major component of the inner surface of caveolae,small invaginations of the plasma membrane,expressed in brain endothelial and astroglial cells,localized to the Golgi complex,colocalizing and forming a stable hetero-oligomeric complex with CAV1,involved in essential cellular functions,including signal transduction,lipid metabolism,cellular growth control and apoptosis
UniProtKB/Swiss-Prot Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).

Gene Ontology (GO) - Molecular Function for CAV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11294831
GO:0019901 protein kinase binding IEA --
GO:0031748 D1 dopamine receptor binding IPI 15569306
GO:0032947 protein complex scaffold IEA --
genes like me logo Genes that share ontologies with CAV2: view
genes like me logo Genes that share phenotypes with CAV2: view

Animal Models for CAV2 Gene

MGI Knock Outs for CAV2:

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAV2 Gene

Localization for CAV2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAV2 Gene

Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAV2 Gene COMPARTMENTS Subcellular localization image for CAV2 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CAV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0048471 perinuclear region of cytoplasm IDA 18081315
genes like me logo Genes that share ontologies with CAV2: view

Pathways & Interactions for CAV2 Gene

genes like me logo Genes that share pathways with CAV2: view

Pathways by source for CAV2 Gene

SIGNOR curated interactions for CAV2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CAV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016050 vesicle organization IDA 12743374
GO:0043547 positive regulation of GTPase activity IDA 8552590
GO:0044794 positive regulation by host of viral process IMP 25556234
genes like me logo Genes that share ontologies with CAV2: view

Drugs & Compounds for CAV2 Gene

(10) Drugs for CAV2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for CAV2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CAV2: view

Transcripts for CAV2 Gene

Unigene Clusters for CAV2 Gene

Caveolin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAV2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1: - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for CAV2 Gene

GeneLoc Exon Structure for
CAV2
ECgene alternative splicing isoforms for
CAV2

Expression for CAV2 Gene

mRNA expression in normal human tissues for CAV2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CAV2 Gene

This gene is overexpressed in Colon muscle (10.2) and Urinary Bladder (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAV2 Gene



SOURCE GeneReport for Unigene cluster for CAV2 Gene Hs.212332

mRNA Expression by UniProt/SwissProt for CAV2 Gene

P51636-CAV2_HUMAN
Tissue specificity: Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.
genes like me logo Genes that share expression patterns with CAV2: view

Protein tissue co-expression partners for CAV2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CAV2 Gene

Orthologs for CAV2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAV2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAV2 35
  • 90.95 (n)
  • 88.27 (a)
CAV2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAV2 35
  • 84.77 (n)
  • 80.25 (a)
CAV2 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cav2 35
  • 86.63 (n)
  • 90.12 (a)
Cav2 16
Cav2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAV2 35
  • 99.59 (n)
  • 100 (a)
CAV2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cav2 35
  • 86.83 (n)
  • 88.89 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia CAV2 36
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAV2 35
  • 73.71 (n)
  • 66.46 (a)
CAV2 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAV2 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cav2 35
  • 67.92 (n)
  • 66.87 (a)
Str.8533 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3397 35
zebrafish
(Danio rerio)
Actinopterygii cav2 35
  • 57.14 (n)
  • 50.93 (a)
cav2 36
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cav-2 36
  • 13 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6318 36
  • 21 (a)
ManyToMany
Species with no ortholog for CAV2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAV2 Gene

ENSEMBL:
Gene Tree for CAV2 (if available)
TreeFam:
Gene Tree for CAV2 (if available)

Paralogs for CAV2 Gene

Paralogs for CAV2 Gene

(3) SIMAP similar genes for CAV2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CAV2: view

Variants for CAV2 Gene

Sequence variations from dbSNP and Humsavar for CAV2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs8940 - 116,506,020(+) CAGTG(C/G)AGACA reference, missense
rs1052990 -- 116,508,316(+) ACTGT(G/T)TGACT utr-variant-3-prime
rs1055850 -- 116,506,657(-) TTTCA(C/T)ATTTA utr-variant-3-prime
rs1055955 -- 116,507,342(-) TGAAA(C/T)AGGAC utr-variant-3-prime
rs12668473 -- 116,505,585(+) AGGCA(C/T)GTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAV2 Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
nsv831106 CNV Gain 17160897

Variation tolerance for CAV2 Gene

Residual Variation Intolerance Score: 66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.56; 77.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAV2 Gene

HapMap Linkage Disequilibrium report
CAV2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAV2 Gene

Disorders for CAV2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CAV2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
open-angle glaucoma
  • glaucoma simplex
glaucoma 1, open angle, e
  • primary open angle glaucoma
- elite association - COSMIC cancer census association via MalaCards
Search CAV2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CAV2

Genetic Association Database (GAD)
CAV2
Human Genome Epidemiology (HuGE) Navigator
CAV2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAV2
genes like me logo Genes that share disorders with CAV2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAV2 Gene

Publications for CAV2 Gene

  1. Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. (PMID: 8552590) Scherer P.E. … Lisanti M.P. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23 67
  2. Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors. (PMID: 10087206) Fra A.M. … Sitia R. (Genomics 1999) 2 3 23
  3. Distribution and significance of caveolin 2 expression in normal breast and invasive breast cancer: an immunofluorescence and immunohistochemical analysis. (PMID: 17912630) Savage K. … Reis-Filho J.S. (Breast Cancer Res. Treat. 2008) 3 23
  4. Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells. (PMID: 18081315) Sowa G. … Sessa W.C. (Biochemistry 2008) 3 23
  5. The overexpression of caveolin-1 and caveolin-2 correlates with a poor prognosis and tumor progression in esophageal squamous cell carcinoma. (PMID: 17671707) Ando T. … Kuwabara Y. (Oncol. Rep. 2007) 3 23

Products for CAV2 Gene

Sources for CAV2 Gene

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