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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAV2 Gene

protein-coding   GIFtS: 67
GCID: GC07P115926

Caveolin 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Caveolin 21 2
CAV2
Caveolae Protein, 20-KD2
Caveolin 2 Isoform A And B2
caveolin-22

External Ids:    HGNC: 15281   Entrez Gene: 8582   Ensembl: ENSG000001059717   OMIM: 6010485   UniProtKB: P516363   

Export aliases for CAV2 gene to outside databases

Previous GC identifers: GC07P114617 GC07P115680 GC07P115694 GC07P115693 GC07P115733 GC07P110505


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAV2 Gene:
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the
plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid
metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and
related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins
that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different
isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame
translation initiation codons have also been described, and shown to have preferential localization in the cell
(PMID:11238462). (provided by RefSeq, May 2011)

GeneCards Summary for CAV2 Gene: 
CAV2 (caveolin 2) is a protein-coding gene. Diseases associated with CAV2 include splenic marginal zone lymphoma, and hepatopulmonary syndrome, and among its related super-pathways are Focal Adhesion and Development EGFR signaling pathway. GO annotations related to this gene include protein homodimerization activity and syntaxin binding. An important paralog of this gene is CAV1.

UniProtKB/Swiss-Prot: CAV2_HUMAN, P51636
Function: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha
subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in
targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating
mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required
for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation
of cell cycle progression (By similarity)

Gene Wiki entry for CAV2 (Caveolin 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAV2 gene promoter:
         E2F-4   E2F-3a   E2F-5   ATF-2   E2F-2   C/EBPalpha   E2F   E2F-1   c-Jun   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CAV2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAV2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAV2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.1   Ensembl cytogenetic band:  7q31.2   HGNC cytogenetic band: 7q31

CAV2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAV2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P115926:  view genomic region     (about GC identifiers)

Start:
115,927,434 bp from pter      End:
116,148,595 bp from pter
Size:
221,162 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 115,535,087-115,544,028     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAV2_HUMAN, P51636 (See protein sequence)
Recommended Name: Caveolin-2  
Size: 162 amino acids; 18291 Da
Subunit: Monomer or homodimer. Interacts with CAV1; the interaction forms a stable heterooligomeric complex that
is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form
heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a
monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and
SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is
increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the
interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the
interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity)
Subcellular location: Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane;
Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like
structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of
cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By
similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated
Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular
compartments
Secondary accessions: A4D0U2 Q9UGM7
Alternative initiation: 3 isoforms:  P51636-1   P51636-2   P51636-3   (Produced by alternative splicing)

Explore the universe of human proteins at neXtProt for CAV2: NX_P51636

Explore proteomics data for CAV2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the
    complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis
    in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced
    'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced
    phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin
    (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51636

  • CAV2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CAV2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001193676.1  NP_001193677.1  NP_001224.1  NP_937855.1  

    ENSEMBL proteins: 
     ENSP00000222693   ENSP00000345679   ENSP00000377120  

    Human Recombinant Protein Products for CAV2: 
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    Novus Biologicals CAV2 Protein
    Novus Biologicals CAV2 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CAV2 

    Gene Ontology (GO): 5/19 cellular component terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0002080acrosomal membrane IEA--
    GO:0005622intracellular IDA15703204
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----

    CAV2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001612 Caveolin
     IPR018361 Caveolin_CS

    Graphical View of Domain Structure for InterPro Entry P51636

    ProtoNet protein and cluster: P51636

    1 Blocks protein domain: IPB001612 Caveolin

    UniProtKB/Swiss-Prot: CAV2_HUMAN, P51636
    Similarity: Belongs to the caveolin family


    CAV2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAV2_HUMAN, P51636
    Function: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha
    subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in
    targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating
    mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required
    for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation
    of cell cycle progression (By similarity)

         Genatlas biochemistry entry for CAV2:
    caveolin,major component of the inner surface of caveolae,small invaginations of the plasma membrane,expressed in
    brain endothelial and astroglial cells,localized to the Golgi complex,colocalizing and forming a stable
    hetero-oligomeric complex with CAV1,involved in essential cellular functions,including signal transduction,lipid
    metabolism,cellular growth control and apoptosis

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding ----
    GO:0005515protein binding IPI11294831
    GO:0019905syntaxin binding IEA--
    GO:0031748D1 dopamine receptor binding IPI15569306
    GO:0042803protein homodimerization activity IDA8552590
         
    CAV2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CAV2:
     Decreased Tat-dependent transc  Decreased focal adhesion (FA)   Decreased p24 protein expressi  Increased Salmonella enterica  

         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cav2):
     adipose tissue  cardiovascular system  cellular  endocrine/exocrine gland  growth/size 
     homeostasis/metabolism  muscle  other  respiratory system 

    CAV2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cav2tm1Mls for CAV2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CAV2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAV2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAV2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAV2 

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    SwitchGear 3'UTR luciferase reporter plasmidCAV2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CAV2 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    2Development EGFR signaling pathway
    EGF Pathway0.41
    3Endocytic Trafficking of EGFR
    Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF)0.35
    4Syndecan-2-mediated signaling events
    Syndecan-2-mediated signaling events
    5Remodeling of Adherens Junctions
    Remodeling of Adherens Junctions

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAV2
        Remodeling of Adherens Junctions
    EGF Pathway

    1 Cell Signaling Technology (CST) Pathway for CAV2
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for CAV2
        Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF)

    4 BioSystems Pathways for CAV2
        Focal Adhesion
    EGFR1 Signaling Pathway
    Integrin-mediated cell adhesion
    Syndecan-2-mediated signaling events



    4         Kegg Pathways  (Kegg details for CAV2):
        Endocytosis
    Focal adhesion
    Bacterial invasion of epithelial cells
    Proteoglycans in cancer


    CAV2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CAV2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/22 Interacting proteins for CAV2 (P516362, 3 ENSP000002226934) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOLGB1Q147892, 3, ENSP000003418484MINT-64180 I2D: score=4 STRING: ENSP00000341848
    DNAJA1P316892, 3, ENSP000003691274MINT-8250679 I2D: score=2 STRING: ENSP00000369127
    CAV1Q031353, ENSP000003391914I2D: score=3 STRING: ENSP00000339191
    RASA1P209363, ENSP000002743764I2D: score=2 STRING: ENSP00000274376
    MALLQ130213, ENSP000002724624I2D: score=1 STRING: ENSP00000272462
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001937negative regulation of endothelial cell proliferation ISS--
    GO:0001938positive regulation of endothelial cell proliferation IEA--
    GO:0006906vesicle fusion IDA12743374
    GO:0007005mitochondrion organization ISS--
    GO:0007029endoplasmic reticulum organization ISS--

    CAV2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CAV2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CAV2

    10/15 Novoseek inferred chemical compound relationships for CAV2 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholesterol 38 12 11907140 (2), 12730355 (1), 12867544 (1), 17303668 (1) (see all 7)
    lipid 34.1 22 12867544 (3), 18081315 (3), 17303668 (2), 12730355 (1) (see all 12)
    tyrosine 28.6 11 15504032 (7), 19895792 (1), 15545264 (1), 12091389 (1)
    sucrose 17.8 2 10600487 (1), 18081315 (1)
    dihydrotestosterone 14.7 1 14576147 (1)
    atp 0 1 11278795 (1)
    nitric oxide 0 2 18717816 (1)
    glucose 0 1 16803459 (1)
    fatty acid 0 3 11278795 (1), 16803459 (1)
    alanine 0 3 15504032 (2), 19778377 (1)

    Search CenterWatch for drugs/clinical trials and news about CAV2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CAV2 gene (4 alternative transcripts): 
    NM_001206747.1  NM_001206748.1  NM_001233.4  NM_198212.2  

    Unigene Cluster for CAV2:

    Caveolin 2
    Hs.212332  [show with all ESTs]
    Unigene Representative Sequence: NM_001233
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000490906 ENST00000460222 ENST00000477018(uc003vhv.2) ENST00000484156
    ENST00000467035(uc003vhw.2) ENST00000489776(uc003vhs.1) ENST00000484871(uc010lkc.2)
    ENST00000485561(uc010lkb.1) ENST00000472470(uc003vhx.2) ENST00000495046(uc003vht.1)
    ENST00000497046(uc003vhu.1 uc003vhy.1) ENST00000491643 ENST00000498493(uc003via.2)
    ENST00000478226(uc003vib.2) ENST00000462876(uc003vhz.2) ENST00000476156
    ENST00000465451 ENST00000222693(uc003vid.3 uc003vie.3 uc022akj.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB451285.1 AB451417.1 AF035752.1 AK024513.1 AK310786.1 AK311964.1 AY353255.1 BC005256.1 
    BT007051.1 CR407685.1 DQ656010.2 DQ656011.2 DQ656012.2 DQ656014.2 DQ656016.2 DQ656017.2 
    DQ656068.1 DQ656069.1 EF070113.1 EF070114.1 EF070115.1 EF070120.1 

    15 DOTS entries:

    DT.455952  DT.92438097  DT.100791767  DT.95194984  DT.99941296  DT.121641096  DT.97777809  DT.100791766 
    DT.95285530  DT.99931724  DT.100791770  DT.121091609  DT.99988109  DT.121091577  DT.92438094 

    24/188 AceView cDNA sequences (see all 188):

    BM848465 BM760304 AA486567 BE677215 BM841156 CD516968 CR407685 AA878149 
    NM_198212 AA367026 BM838686 CF127914 CR604437 AY353255 BU687757 BM840492 
    NM_001233 BG777119 AA344857 AI864109 AA345513 AU137817 CD514571 AI762868 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CAV2    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d
    SP1:        -     -           -                                 
    SP2:                          -                                 
    SP3:                          -     -                           
    SP4:                                                            


    ECgene alternative splicing isoforms for CAV2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAV2 expression in normal human tissues (normalized intensities)      CAV2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTTGTTT
    CAV2 Expression
    About this image


    CAV2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             cervix, uterine ; glandular cells   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Peripheral blood endothelial colony-forming cells
             colon ; endothelial cells   
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Renal Collecting Duct System
             kidney ; cells in glomeruli   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             lung ; pneumocytes   

    See CAV2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAV2

    SOURCE GeneReport for Unigene cluster: Hs.212332

    UniProtKB/Swiss-Prot: CAV2_HUMAN, P51636
    Tissue specificity: Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts

        SABiosciences Expression via Pathway-Focused PCR Arrays including CAV2: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CAV2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cav21 , 5 caveolin 21, 5 86.63(n)1
    90.12(a)1
      6 (7.72 cM)5
    123901  NM_016900.31  NP_058596.11 
     172811855 
    chicken
    (Gallus gallus)
    Aves CAV21 caveolin 2 73.71(n)
    66.46(a)
      417772  NM_001007086.1  NP_001007087.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAV26
    --
    Caveolin
    60(a)
    34(a)
    1 ↔ 1
    possible ortholog
    5(60951470-60970122)
    2(88205979-88209462)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.33972 Xenopus laevis transcribed sequence with weak similarity more 74.79(n)    BJ067198.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cav21 caveolin 2 57.14(n)
    50.93(a)
      415240  NM_001002150.1  NP_001002150.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cav-26
    cav-16
    Caveolin-1
    13(a)
    13(a)
    possible ortholog
    1 ↔ many
    V(13557160-13559922)
    IV(9771154-9773474)


    ENSEMBL Gene Tree for CAV2 (if available)
    TreeFam Gene Tree for CAV2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAV2 gene
    CAV12  CAV32  
    3 SIMAP similar genes for CAV2 using alignment to 3 protein entries:     CAV2_HUMAN (see all proteins):
    caveolin-2    CAV1    CAV3

    CAV2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/283 SNPs in CAV2 are shown (see all 283)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1998124461,2
    --115535940(+) GAGACA/GGGGCA 4 -- int10--------
    rs345451791,2
    C--115537963(+) TTAGCT/-TATGC 4 -- int11Minor allele frequency- -:0.50NA 2
    rs353007991,2
    C--115539085(+) AAGCT-/GGGCAG 4 -- int11Minor allele frequency- G:0.00NA 2
    rs717735821,2
    C--115539538(+) GAAAG-/AGAA  
            
    AGAAA
    4 -- int11Minor allele frequency- AGAA:0.00CSA 2
    rs30308041,2
    C--116138977(+) ACACAC/AACACA 4 -- us2k13Minor allele frequency- A:0.20NA CSA 5
    rs559603841,2
    C--116139017(+) AAAAAA/-TCAGA 4 -- us2k11Minor allele frequency- -:0.00NA 2
    rs32143171,2
    C--116140509(+) GAGACG/-GGGCA 4 -- int11Minor allele frequency- -:0.00NA 2
    rs577211161,2
    C--116144093(+) AAAGA-/AAGA  
            
    GAAAG
    4 -- int10--------
    rs171387671,2
    C,F,H--119489110(+) TTTTTA/GCCCAC 3 -- us2k116Minor allele frequency- G:0.11NA NS EA 1226
    rs1143241891,2
    C,F--119489134(+) TCTTGT/CACTAG 3 -- us2k11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for CAV2 (115927434 - 116148595 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CAV2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831106CNV Gain17160897
    nsv7405OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601048    OMIM disorders: --

    20/50 diseases for CAV2 (see all 50):    About MalaCards
    splenic marginal zone lymphoma    hepatopulmonary syndrome    cerebral amyloid angiopathy    parathyroid adenoma
    primary open angle glaucoma    open-angle glaucoma    primary biliary cirrhosis    glaucoma
    rabies    conjunctivitis    colon adenocarcinoma    esophageal squamous cell carcinoma
    ulcerative colitis    fibrosarcoma    bronchiolitis    colon cancer
    adenoma    muscular dystrophy    prostate cancer    cerebritis

    1 disease from the University of Copenhagen DISEASES database for CAV2:
    Rabies

    CAV2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/12 Novoseek inferred disease relationships for CAV2 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 17.2 21 12866378 (4), 9662443 (2), 12620387 (2), 15252854 (2) (see all 10)
    adenocarcinoma 10.2 3 15095482 (1), 15069532 (1), 11345836 (1)
    prostate cancer 2.9 2 12743374 (1)
    adenoma 2.04 3 11345836 (2), 12970324 (1)
    colon cancer 1.66 2 12414992 (1)
    carcinoma squamous cell 0 2 17671707 (2)
    necrosis 0 1 11278795 (1)
    breast cancer 0 15 15305200 (6), 17912630 (3), 18612310 (3)
    metastasis 0 1 16207479 (1)
    bladder cancer 0 1 16909110 (1)

    Genetic Association Database (GAD): CAV2
    Human Genome Epidemiology (HuGE) Navigator: CAV2 (12 documents)

    Export disorders for CAV2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAV2 gene, integrated from 9 sources (see all 191):
    (articles sorted by number of sources associating them with CAV2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. (PubMed id 8552590)1, 2, 3, 9 Scherer P.E....Lisanti M.P. (1996)
    2. Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27). (PubMed id 15504032)1, 2, 9 Wang X.B....Lisanti M.P. (2004)
    3. Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho- caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. (PubMed id 12091389)1, 2, 9 Lee H....Lisanti M.P. (2002)
    4. Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells. (PubMed id 18081315)1, 2, 9 Sowa G....Sessa W.C. (2008)
    5. Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo. (PubMed id 9361015)1, 2, 9 Scherer P.E.... Lisanti M.P. (1997)
    6. Analysis of candidate genes for prostate cancer. (PubMed id 15583422)1, 4, 9 Burmester J.K....Catalona W.J. (2004)
    7. Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors. (PubMed id 10087206)1, 3, 9 Fra A.M....Sitia R. (1999)
    8. Genetic Risk Factors for Hepatopulmonary Syndrome in Patients With Advanced Liver Disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (2010)
    9. Common variants near CAV1 and CAV2 are associated wit h primary open-angle glaucoma. (PubMed id 20835238)1, 4 Thorleifsson G....Stefansson K. (2010)
    10. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 858 HGNC: 1528 AceView: CAV2 Ensembl:ENSG00000105971 euGenes: HUgn858
    ECgene: CAV2 Kegg: 858 H-InvDB: CAV2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAV2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CAV2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Caveolin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CAV2 gene:
    Search GeneIP for patents involving CAV2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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