Aliases for CAV2 Gene
Aliases for CAV2 Gene
External Ids for CAV2 Gene
- HGNC: 1528
- Entrez Gene: 858
- Ensembl: ENSG00000105971
- OMIM: 601048
- UniProtKB: P51636
Previous GeneCards Identifiers for CAV2 Gene
- GC07P114617
- GC07P115680
- GC07P115694
- GC07P115693
- GC07P115733
- GC07P115926
- GC07P110505
Summaries for CAV2 Gene
-
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]
GeneCards Summary for CAV2 Gene
CAV2 (Caveolin 2) is a Protein Coding gene. Diseases associated with CAV2 include Open-Angle Glaucoma and Glaucoma 1, Open Angle, E. Among its related pathways are Focal Adhesion and Bacterial invasion of epithelial cells. GO annotations related to this gene include protein homodimerization activity and D1 dopamine receptor binding. An important paralog of this gene is CAV1.
UniProtKB/Swiss-Prot for CAV2 Gene
-
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAV2 Gene
Genomics for CAV2 Gene
Regulatory Elements for CAV2 Gene
Enhancers for CAV2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CAV2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CAV2 gene promoter:
Regulatory Element Products
Genomic Location for CAV2 Gene
- Chromosome:
- 7
- Start:
- 116,287,380 bp from pter
- End:
- 116,508,541 bp from pter
- Size:
- 221,162 bases
- Orientation:
- Plus strand
Genomic View for CAV2 Gene
Genes around CAV2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q31.2 by Ensembl
- 7q31.2 by Entrez Gene
- 7q31.2 by HGNC
CAV2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CAV2 Gene
Proteins for CAV2 Gene
-
Protein details for CAV2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P51636-CAV2_HUMAN
- Recommended name:
- Caveolin-2
- Protein Accession:
- P51636
- A4D0U2
- Q9UGM7
Protein attributes for CAV2 Gene
- Size:
- 162 amino acids
- Molecular mass:
- 18291 Da
- Quaternary structure:
-
- Monomer or homodimer. Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).
Protein Expression for CAV2 Gene
Post-translational modifications for CAV2 Gene
- Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced Ser-727 phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CAV2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CAV2 (Caveolin-2)
- Cell Signaling Technology (CST) Antibodies for CAV2 (Caveolin-2)
-
Custom Antibody ServicesOriGene Antibodies for CAV2
- Novus Biologicals Antibodies for CAV2
- Invitrogen Antibodies for CAV2
- antibodies-online Antibodies for CAV2: See all 97
- GeneTex CAV2 antibody for CAV2
-
Santa Cruz Biotechnology (SCBT) Antibodies for CAV2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CAV2
- Origene Custom Protein Services for CAV2
- antibodies-online Proteins for CAV2: See all 25
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CAV2
Assay Products
- antibodies-online Kits for CAV2: See all 4
No data available for DME Specific Peptides for CAV2 Gene
Domains & Families for CAV2 Gene
Protein Domains for CAV2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CAV2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P51636- Family:
-
- Belongs to the caveolin family.
No data available for Gene Families for CAV2 Gene
Function for CAV2 Gene
Molecular function for CAV2 Gene
- GENATLAS Biochemistry:
- caveolin,major component of the inner surface of caveolae,small invaginations of the plasma membrane,expressed in brain endothelial and astroglial cells,localized to the Golgi complex,colocalizing and forming a stable hetero-oligomeric complex with CAV1,involved in essential cellular functions,including signal transduction,lipid metabolism,cellular growth control and apoptosis
- UniProtKB/Swiss-Prot Function:
- May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11294831 |
| GO:0019901 | protein kinase binding | IEA | -- |
| GO:0030674 | protein binding, bridging | IEA | -- |
| GO:0032947 | protein complex scaffold | IEA | -- |
| GO:0042803 | protein homodimerization activity | IDA | 8552590 |
Phenotypes for CAV2 Gene
- MGI mutant phenotypes for CAV2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CAV2:
-
- Increased vaccinia virus (VACV) infection
- Decreased p24 protein expression
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased Salmonella enterica Typhimurium invasion
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased Tat-dependent transcription
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CAV2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CAV2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CAV2 gene
- Search ViGene Biosciences for CAV2
CRISPR Products
-
OriGene CRISPR knockouts for CAV2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAV2
- GenScript: Design CRISPR guide RNA sequences for CAV2
miRNA for CAV2 Gene
- miRTarBase miRNAs that target CAV2
-
- hsa-mir-199a-3p (MIRT006655)
- hsa-mir-93-5p (MIRT028136)
- hsa-mir-26b-5p (MIRT029751)
- hsa-mir-365b-5p (MIRT659795)
- hsa-mir-365a-5p (MIRT659796)
- hsa-mir-8052 (MIRT659797)
- hsa-mir-3199 (MIRT659798)
- hsa-mir-6778-3p (MIRT659799)
- hsa-mir-1976 (MIRT659800)
- hsa-mir-3653-5p (MIRT659801)
- hsa-mir-6747-3p (MIRT659802)
- hsa-mir-6727-3p (MIRT659803)
- hsa-mir-4722-3p (MIRT659804)
- hsa-mir-4726-3p (MIRT659805)
- hsa-mir-6764-5p (MIRT659806)
- hsa-mir-1915-3p (MIRT659807)
- hsa-mir-6840-3p (MIRT659808)
- hsa-mir-552-3p (MIRT659809)
- hsa-mir-498 (MIRT675821)
- hsa-mir-4279 (MIRT675822)
- hsa-mir-5571-5p (MIRT675823)
miRNA Products
- Search ViGene Biosciences for CAV2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CAV2
- Browse OriGene Inhibitory RNA Products For CAV2
-
ViGene Biosciences ready-to-package AAV shRNAs for CAV2 gene
Clone Products
- Sino Biological Human cDNA Clone for CAV2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CAV2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAV2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CAV2
-
ViGene Biosciences adenoviral particle packaged cDNA for CAV2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CAV2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CAV2 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12312 VA4-10814) for CAV2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAV2 Gene
Localization for CAV2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CAV2 Gene
- Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| golgi apparatus | 5 |
| extracellular | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0002080 | acrosomal membrane | IEA | -- |
| GO:0005622 | intracellular | IDA | 15703204 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for CAV2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Focal Adhesion |
.62
.62
|
|
| 2 | Bacterial invasion of epithelial cells | ||
| 3 | Endocytosis | ||
| 4 | Fluid shear stress and atherosclerosis | ||
| 5 | Proteoglycans in cancer | ||
Pathways by source for CAV2 Gene
1 Cell Signaling Technology pathway for CAV2 Gene
4 BioSystems pathways for CAV2 Gene
5 KEGG pathways for CAV2 Gene
1 GeneGo (Thomson Reuters) pathway for CAV2 Gene
2 Qiagen pathways for CAV2 Gene
Interacting Proteins for CAV2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001937 | negative regulation of endothelial cell proliferation | ISS | -- |
| GO:0001938 | positive regulation of endothelial cell proliferation | IEA | -- |
| GO:0006906 | vesicle fusion | IDA | 12743374 |
| GO:0007005 | mitochondrion organization | ISS | -- |
| GO:0007029 | endoplasmic reticulum organization | ISS | -- |
Transcripts for CAV2 Gene
mRNA/cDNA for CAV2 Gene
- (4) REFSEQ mRNAs :
- (22) Additional mRNA sequences :
- (188) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CAV2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAV2
- GenScript: Design CRISPR guide RNA sequences for CAV2
miRNA Products
- Search ViGene Biosciences for CAV2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CAV2
- Browse OriGene Inhibitory RNA Products For CAV2
-
ViGene Biosciences ready-to-package AAV shRNAs for CAV2 gene
Clone Products
- Sino Biological Human cDNA Clone for CAV2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CAV2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAV2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12312 VA4-10814) for CAV2
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||
| SP2: | - | ||||||||||||||||||
| SP3: | - | - | |||||||||||||||||
| SP4: |
Expression for CAV2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Smooth Muscle (Muscoskeletal System)
- Lung (Respiratory System)
This gene is overexpressed in Colon muscle (10.2) and Urinary Bladder (8.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAV2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CAV2 Gene:
CAV2SOURCE GeneReport for Unigene cluster for CAV2 Gene:
Hs.212332mRNA Expression by UniProt/SwissProt for CAV2 Gene:
P51636-CAV2_HUMAN
Tissue specificity:
Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.
Evidence on tissue expression from TISSUES for CAV2 Gene
- Kidney(4.6)
- Liver(4.4)
- Nervous system(3.1)
- Heart(3)
- Muscle(3)
- Lung(2.9)
- Thyroid gland(2.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for CAV2
-
OriGene qPCR primer pairs for CAV2
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAV2 Gene
Orthologs for CAV2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CAV2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CAV2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cav2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cav2 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CAV2 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CAV2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CAV2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CAV2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cav2 34 |
|
||
| Str.8533 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3397 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cav2 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | cav-2 35 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6318 35 |
|
ManyToMany |
- Species where no ortholog for CAV2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CAV2 Gene
(3) SIMAP similar genes for CAV2 Gene using alignment to 3 proteins:
Variants for CAV2 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000089535 | -- | 116,498,109(+) | AATTA(C/T)TAGAA | intron-variant, upstream-variant-2KB | |
| rs1000279184 | -- | 116,497,771(+) | CAGTT(C/G)ATATT | intron-variant, upstream-variant-2KB | |
| rs1000304686 | -- | 116,501,386(+) | ATAAC(C/G)CAAGG | intron-variant, upstream-variant-2KB | |
| rs1000440118 | -- | 116,501,053(+) | GCGGG(A/T)TAATG | intron-variant, upstream-variant-2KB | |
| rs1000644615 | -- | 116,499,057(+) | CTCCA(C/T)ATGCA | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3572091 | CNV | loss | 25503493 |
| esv3891195 | CNV | gain | 25118596 |
| nsv1019254 | CNV | gain | 25217958 |
| nsv7405 | OTHER | inversion | 18451855 |
| nsv831106 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.56;
77.92% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CAV2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CAV2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAV2 Gene
Disorders for CAV2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| open-angle glaucoma |
|
|
| glaucoma 1, open angle, e |
|
|
Search CAV2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CAV2
No data available for UniProtKB/Swiss-Prot and Genatlas for CAV2 Gene
Publications for CAV2 Gene
- Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. (PMID: 8552590) Scherer P.E. … Lisanti M.P. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 22 64
- Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells. (PMID: 18081315) Sowa G. … Sessa W.C. (Biochemistry 2008) 3 4 22 64
- Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27). (PMID: 15504032) Wang X.B. … Lisanti M.P. (Biochemistry 2004) 3 4 22 64
- Analysis of candidate genes for prostate cancer. (PMID: 15583422) Burmester J.K. … Catalona W.J. (Hum. Hered. 2004) 3 22 46 64
- Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho- caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. (PMID: 12091389) Lee H. … Lisanti M.P. (J. Biol. Chem. 2002) 3 4 22 64
Products for CAV2 Gene
- R&D Systems Antibodies for CAV2 (Caveolin-2)
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- Novus Biologicals Antibodies for CAV2
- Novus Biologicals proteins and lysates for CAV2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for CAV2: See all 97
- antibodies-online Kits for CAV2: See all 4
- antibodies-online Proteins for CAV2: See all 25
- Search antibodies-online for peptides
- GeneTex CAV2 antibody for CAV2
- Search GeneTex for Proteins for CAV2
- ViGene Biosciences adenoviral particle packaged cDNA for CAV2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CAV2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CAV2 gene
- Search ViGene Biosciences for CAV2
- Santa Cruz Biotechnology (SCBT) Antibodies for CAV2
- Search Santa Cruz Biotechnology (SCBT) for CAV2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CAV2
- Horizon Cell Lines for CAV2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CAV2
- VectorBuilder custom plasmid, inducible vectors for CAV2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAV2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CAV2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer