V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

CAV1 Gene

protein-coding GIFtS: 68

GC07P115952

caveolin 1, caveolae protein, 22kDa
(Previous names: caveolin 1, caveolae protein, 22kD )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CAV)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BSCL3 ^², ⁵
CAV ^², ³
CGL3 ^², ⁵
MSTP085 ^²
OTTHUMP00000025031 ^²
VIP21 ^²

Descriptions
caveolae protein, 22-kD ^²
caveolin 1 ^²
caveolin 1, alpha isoform ^²
caveolin 1, beta isoform ^²
caveolin 1, caveolae protein, 22kD ^¹
caveolin 1, caveolae protein, 22kDa ^²
cell growth-inhibiting protein 32 ^²

External Ids
HGNC: 1527¹
Entrez Gene: 857²
UniProtKB: Q03135³
Ensembl: ENSG00000105974⁷

Search outside databases for aliases for CAV1 gene

Previous GC identifers: GC07P114642 GC07P115705 GC07P115719 GC07P115758

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CAV1:

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes

found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an

initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression.

The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP

kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express

colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative

initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single

transcript from this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: CAV1_HUMAN, Q03135

Function: May act as a scaffolding protein within caveolar membranes. Interacts directly with

G-protein alpha subunits and can functionally regulate their activity (By similarity)

Gene Wiki entry for CAV1 (Caveolin_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CAV1 gene

Entrez Gene cytogenetic band: 7q31.1 Ensembl cytogenetic band: 7q31.2 HGNC cytogenetic band: 7q31

CAV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P115952: (about GC identifiers)

Start:	115,952,075 bp from pter
End:	115,988,469 bp from pter
Size:	36,395 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 115,560,275-115,596,670

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CAV1_HUMAN, Q03135 (See protein sequence)

Recommended Name: Caveolin-1

Size: 178 amino acids; 20472 Da

Subunit: Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with

rotavirus A NSP4

Subcellular location: Golgi apparatus membrane; Single-pass membrane protein. Cell membrane;

Single-pass membrane protein. Membrane, caveola; Single-pass membrane protein. Note=Potential

hairpin-like structure in the membrane. Membrane protein of caveolae

Secondary accessions: Q9UGP1 Q9UNG1 Q9UQH6

Alternative initiation: 2 isoforms: Q03135-1 Q03135-2

Post-translational modifications:

The initiator methionine for isoform Beta is removed during or just after translation. The new

N-terminal amino acid is then N-acetylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001744.2

ENSEMBL proteins:

ENSP00000339191 ENSP00000377113 ENSP00000384348 ENSP00000377111 ENSP00000377110

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Caveolin 1)
	Human Recombinant Proteins from Abnova (CAV1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/8 Gene Ontology (GO) cellular component terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IDA	11294831
GO:0005783	endoplasmic reticulum	IDA	11294831
GO:0005794	Golgi apparatus	IEA	--
GO:0005811	lipid particle	EXP	9188442 9580552 10781589 16722822 16807357
GO:0005886	plasma membrane	IEA	--

About this table

Antibodies for CAV1:

	Invitrogen Antibodies for CAV1
	Millipore Mono- and Polyclonal Antibodies for the study of CAV1
	Sigma-Aldrich Antibody Arrays and Antibodies for CAV1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CAV1 (Caveolin-1)
	Antibodies from Abcam (Caveolin 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CAV1)
	Novus Biologicals Antibodies for CAV1

Assays for CAV1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q03135

ProtoNet protein and cluster: Q03135

1 Blocks protein family: IPB001612 Caveolin

UniProtKB/Swiss-Prot: CAV1_HUMAN, Q03135

Similarity: Belongs to the caveolin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CAV1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001753

Applied Biosystems Silencer® siRNAs for CAV1

Sigma-Aldrich siRNA and siRNA Panels for CAV1

Sigma-Aldrich shRNA Panels and shRNA for CAV1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CAV1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001753
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001753
untagged cDNA clone in CMV expression vector: NM_001753

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001753

UniProtKB/Swiss-Prot: CAV1_HUMAN, Q03135

Function: May act as a scaffolding protein within caveolar membranes. Interacts directly with

G-protein alpha subunits and can functionally regulate their activity (By similarity)

Genatlas biochemistry entry for CAV1:

caveolin,major component of the inner surface of caveolae,small invaginations of the plasma

membrane,expressed in adipocytes,smooth muscle,type I pneumocytes,colocalizing and forming a

stable hetero-oligomeric complex with CAV2,with transforming suppressor activity abnormal

expressed in T cell leukemia in lung carcinoma and in breast cell carcinoma lines) s,relation to

methylation of a CpG island in the 5'promoter region

15/17 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Cav1) (see all 17 ):

	adipose tissue	behavior/neurological	cellular	endocrine/exocrine gland
growth/size	homeostasis/metabolism	immune system	life span-post-weaning/aging	liver/biliary system
muscle	other	renal/urinary system	reproductive system	respiratory system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	IDA	11865038
GO:0005515	protein binding	IPI	16951145
GO:0015485	cholesterol binding	TAS	11294831
GO:0016504	peptidase activator activity	ISS	--
GO:0050998	nitric-oxide synthase binding	IPI	12852865

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5 Sigma-Aldrich "Your Favorite Gene" Pathways for CAV1 (Your Favorite Gene powered by Ingenuity)

Caveolar-mediated Endocytosis
PDGF Signaling
Nitric Oxide Signaling in the Cardiovascular System
Integrin Signaling
Virus Entry via Endocytic Pathways

GeneDecks CAV1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CAV1

5/153 Interacting proteins for CAV1 (ENSP00000339191³ Q03135^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 153 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CAV2	P51636¹	STRING (score=.991) EBI-603614, EBI-603607
FLOT1	O75955¹	STRING (score=.843) EBI-603614, EBI-603643
FLOT2	Q14254¹	STRING (score=.969) EBI-603614, EBI-348613
ID1	P41134¹	STRING (score=.921) EBI-603614, EBI-1215527
PTPN1	P18031²	STRING (score=.988) MINT-6793807 MINT-6793849 MINT-6764852 MINT-6764881 MINT-6764866

About this table

5/29 Gene Ontology (GO) biological process terms (links to tree view) (see all 29 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000188	inactivation of MAPK activity	ISS	--
GO:0001570	vasculogenesis	ISS	--
GO:0001666	response to hypoxia	ISS	--
GO:0001937	negative regulation of endothelial cell proliferation	ISS	--
GO:0006641	triglyceride metabolic process	ISS	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CAV1
10/56 Novoseek chemical compound relationships for CAV1 gene (see all 56 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cholesterol	68.44	161	10833523 (5), 12269838 (5), 11073854 (4), 11287334 (3) (see all 84)
lipid	65.53	167	11980479 (4), 19059381 (3), 19250636 (3), 18635971 (3) (see all 99)
tyrosine	51.34	88	11094059 (7), 15466865 (4), 11339833 (3), 12354760 (3) (see all 47)
nitric oxide	50.53	112	18717816 (8), 9712842 (6), 17112410 (4), 11114180 (2) (see all 52)
gm1 ganglioside	50.52	3	16427620 (1), 10859219 (1), 12226079 (1)
ganglioside	47.80	17	12354760 (4), 17942932 (4), 17704805 (2), 10866823 (1) (see all 7)
sucrose	47.73	27	16038619 (1), 16415176 (1), 18056712 (1), 18079116 (1) (see all 19)
cyclodextrin	43.93	2	12529448 (1), 12372346 (1)
glycolipid	40.94	3	16672766 (1), 11724808 (1), 19017221 (1)
sterol	40.04	7	14992595 (3), 15226391 (1), 18849545 (1), 15388640 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CAV1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001753

Sigma-Aldrich siRNA and siRNA Panels for CAV1

Sigma-Aldrich shRNA Panels and shRNA for CAV1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001753

REFSEQ mRNAs for CAV1 gene:

NM_001753.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001753

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001753
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001753
                                 untagged cDNA clone in CMV expression vector: NM_001753

Additional cDNA sequence:

AB209926.1 AB451284.1 AB451416.1 AF070648.1 AF074993.1 AF172085.1 AK290871.1 AK307501.1

AL133639.1 AY762103.1 BC009685.1 BC082246.1 BT007143.1 EF179101.1 EF179102.1 EF649773.1

EF649774.1 Z18951.1

24/25 DOTS entries (see all 25 ):

DT.100882864 DT.454239 DT.121125607 DT.121125557 DT.121125609 DT.121125597 DT.100718793 DT.100038859

DT.100882861 DT.97862297 DT.100882878 DT.121125509 DT.100882869 DT.100882870 DT.100729430 DT.100882873

DT.75119128 DT.95105984 DT.97767377 DT.100882874 DT.100882877 DT.121125507 DT.121125615 DT.121125618

24/834 AceView cDNA sequences (see all 834 ):

T34600 BQ027115 AA037446 BQ939943 AA861847 AA662526 CB044857 BQ889781

BQ030204 BF437334 CA435754 CA436151 AW298028 AA373326 CA434239 AA972868

BQ002421 W80871 BM669670 CB115559 CB112889 BU681007 AA094362 AL551274

highest scoring ESTs for CAV1:

AA032028 AA034380 AA044994 AA047106 AA055368 AA080891 AA149439 AA159249 AA487560 AA533068

Unigene Cluster for CAV1:

Caveolin 1, caveolae protein, 22kDa

Hs.74034 [show with all ESTs]

Unigene Representative Sequence: NM_001753

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CAV1 (see all 6 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	·	4c	·	4d	·	4e
SP1:							-		-		-						-
SP2:							-		-		-		-				-
SP3:									-		-						-
SP4:											-						-
SP5:							-		-		-

About this scheme

ECgene alternative splicing isoforms for CAV1

5 Ensembl transcripts including schematic representations:

ENST00000341049 ENST00000393470 ENST00000405348 ENST00000393468 ENST00000393467

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CAV1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CAV1

¹ / ² / ³

5 probe-sets matching CAV1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36119_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF070648	0.80	1.00	0.91	1
212097_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AU147399	0.80	1.00	0.91	1
203065_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001753	0.60	1.00	0.82	1
212097_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203065_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CAV1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCCTGTAAAG

SOURCE GeneReport for Unigene cluster: Hs.74034
Expression variation in blood from EXPOLDB for CAV1
UniProtKB/Swiss-Prot: CAV1_HUMAN, Q03135
Tissue specificity: In muscle and lung, less so in liver, brain and kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CAV1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CAV1¹	--	caveolin 1, caveolae protein, 22kDa	93.97(n) 96.61(a)	403980 NM_001003296.1 NP_001003296.1
chimpanzee (Pan troglodytes)	CAV1¹	--	caveolin 1, caveolae protein, 22kDa	100(n) 100(a)	463670 XM_519325.2 XP_519325.2
cow (Bos taurus)	CAV1¹	--	caveolin 1, caveolae protein, 22kDa	93.63(n) 96.07(a)	281040 NM_174004.3 NP_776429.1
rat (Rattus norvegicus)	Cav1¹	--	caveolin 1, caveolae protein	92.51(n) 94.38(a)	25404 NM_031556.1 NP_113744.1
mouse (Mus musculus)	Cav1^{1, 5}	6⁵	caveolin 1, caveolae protein^{1, 5}	92.32(n)¹ 94.94(a)¹	12389¹ NM_007616.3¹ NP_031642.1¹ AB029929⁵ AB029930⁵ (see all 19)

About this table Species with no ortholog for CAV1

ENSEMBL Gene Tree for CAV1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CAV1 gene

CAV2² CAV3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/271 NCBI SNPs in CAV1 are shown (see all 271 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 134)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1049314^1,2	A,C,F,H	115986931(+)	`ACCAAC/AAACCT`	1	--	ut3¹		10		MN CSAM EA EU WA	952
	rs1049337^1,2	A,C,F,H	115987823(+)	`GCATCC/TCTTTG`	1	--	ut3¹		14		EA MN NA CSAM EU WA	2602
--	rs2215448^1,2	C,F,H,O	115951188(+)	`GAAGCG/ATAAGT`	1	--	ng5¹		14		NS EU EA WA MN CSAM	894
	rs8713^1,2	A,C,F,H	115987033(+)	`CAGCAA/CACTCT`	1	--	ut3¹		17		MN NA CSAM EA EU WA	1512
	rs6867^1,2	C,F,H	115987759(+)	`CAACCG/ATCTGT`	1	--	ut3¹ ese³		15		MN CSAM EA EU WA	1602
	rs6955882^1,2	A,F,H	115988792(+)	`CTTAGC/TGAAAG`	1	--	ng3¹		4		EU EA WA	420
	rs9920^1,2	C,F,H	115987328(+)	`GAATAT/CCCATG`	1	--	ut3¹		14		MN CSAM EA EU WA	1412
	rs1049334^1,2	C,F,H	115987616(+)	`TCACCG/AGGGTG`	1	--	ut3¹ ese³		17		MN NA CSAM EA EU WA	1550
--	rs6975442^1,2	C,H	115950524(+)	`ggaagG/AaagAC`	1	--	ng5¹ trp³		4		EU EA WA	410
--	rs6466582^1,2	A,C	115950339(+)	`agaaaA/Gaaaag`	1	--	ng5¹ trp³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for CAV1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601047 disorders: 612526

UniProtKB/Swiss-Prot: CAV1_HUMAN, Q03135

Defects in CAV1 are the cause of congenital generalized lipodystrophy type 3 (CGL3)

[MIM:612526]; also called Berardinelli-Seip congenital lipodystrophy type 3 (BSCL3). Congenital

generalized lipodystrophies are autosomal recessive disorders characterized by a near absence of

adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early

onset of diabetes

10/87 Novoseek disease relationships for CAV1 gene (see all 87 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	48.10	396	18922892 (8), 12759258 (6), 17460461 (5), 11170154 (5) (see all 99)
cancer	44.39	129	12898235 (4), 18300018 (4), 15247769 (4), 15553909 (3) (see all 63)
prostate cancer	43.15	131	14634273 (6), 15948133 (6), 12352463 (5), 14506154 (5) (see all 35)
breast cancer	39.83	104	15305200 (8), 17915016 (5), 19342880 (5), 15334058 (4) (see all 37)
cholera	36.41	7	18729494 (1), 12794078 (1), 18316074 (1), 18755811 (1) (see all 6)
colon cancer	33.81	29	15069532 (3), 17724373 (2), 11059785 (2), 18283336 (2) (see all 16)
metastasis	31.98	86	14764125 (5), 15334058 (5), 19002186 (5), 15355971 (4) (see all 34)
oncocytoma	30.58	4	16613342 (3), 12810205 (1)
adenocarcinoma	29.91	47	17606426 (6), 11345836 (4), 12402154 (2), 19160064 (2) (see all 21)
muscular dystrophies	28.89	2	17629760 (2)

About this table

Human Gene Mutation Database: CAV1
Genetic Association Database: CAV1
Human Genome Epidemiology Navigator: CAV1 (7 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/902 PubMed articles for CAV1 gene (see all 902 ):

Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia. (PubMed id 12368209)^{1, 3, 4} Lee H....Lisanti M.P. (2002)
Association of a CAV-1 haplotype to familial aggressive prostate cancer. (PubMed id 15948133)^{1, 3, 6} Haeusler J....Maier C. (2005)
Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy. (PubMed id 18211975)^{1, 3, 4} Kim C.A....Magre J. (2008)
Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. (PubMed id 16807357)^{1, 3, 4} Schilling K.... Icking A. (2006)
Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors. (PubMed id 10087206)^{1, 2, 3} Fra A.M....Sitia R. (1999)
Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines. (PubMed id 10086342)^{1, 3, 4} Hurlstone A.F.... Black D.M. (1999)
The rotavirus enterotoxin NSP4 directly interacts with the caveolar structural protein caveolin-1. (PubMed id 16501093)^{3, 4} Parr R.D....Ball J.M. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)^{3, 4} Zhang Y.... White F.M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 857	HGNC: 1527	AceView: CAV1	Ensembl:ENSG00000105974	euGenes: HUgn857
ECgene: CAV1	H-InvDB: CAV1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CAV1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CAV1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CAV1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CAV1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CAV1		Antibodies for CAV1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CAV1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CAV1)
	Antibodies (CAV1)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CAV1 (Caveolin-1)

	Recombinant Proteins (Caveolin 1)
	Antibodies (Caveolin 1)

Search OriGene for CAV1

Search Tocris compounds for CAV1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CAV1

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CAV1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

CAV1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for CAV1

Summaries
for CAV1

Genomic Location
for CAV1

Proteins
for CAV1

Protein Domains/
Families
for CAV1

Gene Function
for CAV1

Pathways & Interactions
for CAV1

Drugs & Compounds
for CAV1

Transcripts
for CAV1

Expression
for CAV1

Orthologs
for CAV1

Paralogs
for CAV1

SNPs/Variants
for CAV1

Disorders & Mutations
for CAV1

Medical News
for CAV1

Publications
for CAV1

Search for CAV1

Genome Databases showing CAV1

Other Databases showing CAV1

Specialized Databases showing CAV1

Licensable Technologies
for CAV1

Services
for CAV1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CAV1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor CAV1

Summariesfor CAV1

Genomic Locationfor CAV1

Proteinsfor CAV1

Protein Domains/Familiesfor CAV1

Gene Functionfor CAV1

Pathways & Interactionsfor CAV1

Drugs & Compoundsfor CAV1

Transcriptsfor CAV1

Expression for CAV1

Orthologsfor CAV1

Paralogsfor CAV1

SNPs/Variantsfor CAV1

Disorders & Mutationsfor CAV1

Medical Newsfor CAV1

Publicationsfor CAV1

Search for CAV1

Genome Databases showing CAV1

Other Databases showing CAV1

Specialized Databases showing CAV1

Licensable Technologiesfor CAV1

Servicesfor CAV1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CAV1

Summaries
for CAV1

Genomic Location
for CAV1

Proteins
for CAV1

Protein Domains/
Families
for CAV1

Gene Function
for CAV1

Pathways & Interactions
for CAV1

Drugs & Compounds
for CAV1

Transcripts
for CAV1

Expression
for CAV1

Orthologs
for CAV1

Paralogs
for CAV1

SNPs/Variants
for CAV1

Disorders & Mutations
for CAV1

Medical News
for CAV1

Publications
for CAV1

Licensable Technologies
for CAV1

Services
for CAV1