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Aliases for CATSPERZ Gene

Aliases for CATSPERZ Gene

  • Catsper Channel Auxiliary Subunit Zeta 2 3
  • Testis Expressed 40 2 3 5
  • TEX40 3 4 5
  • C11orf20 3 4
  • Testis-Expressed Sequence 40 Protein 3
  • Chromosome 11 Open Reading Frame 20 2
  • Testis-Expressed Protein 40 3

External Ids for CATSPERZ Gene

Previous HGNC Symbols for CATSPERZ Gene

  • C11orf20
  • TEX40

Summaries for CATSPERZ Gene

GeneCards Summary for CATSPERZ Gene

CATSPERZ (Catsper Channel Auxiliary Subunit Zeta) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CATSPERZ Gene

  • May be involved in late spermatogenesis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CATSPERZ Gene

Genomics for CATSPERZ Gene

Regulatory Elements for CATSPERZ Gene

Enhancers for CATSPERZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G064320 1.4 Ensembl ENCODE dbSUPER 12.2 +22.7 22729 5.3 HDAC1 KLF17 NFXL1 RAD21 ZNF366 EGR1 SCRT2 EGR2 ZNF263 ZBTB2 PLCB3 LOC102723878 ENSG00000257086 CATSPERZ ENSG00000207024 KCNK4-TEX40 KCNK4 BAD GPR137 TRMT112
GH11G064205 1.4 ENCODE dbSUPER 11.5 -92.8 -92796 4.4 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZFPL1 TRPT1 ENSG00000257086 PLCB3 TRMT112 GPR137 BAD KCNK4-TEX40 KCNK4 ENSG00000207024
GH11G064347 0.8 ENCODE 11.5 +48.0 47991 1.9 BCOR KLF1 JUN CHD4 ZMYM3 MAX CEBPG ZNF366 POLR2A FOXK2 LOC102723878 MIR1237 TRMT112 PRDX5 ESRRA CATSPERZ ENSG00000207024 KCNK4 KCNK4-TEX40 BAD
GH11G064299 0.5 ENCODE 0.7 -1.0 -1008 0.2 SUZ12 FUS HNRNPL EZH2 CATSPERZ ENSG00000207024
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CATSPERZ on UCSC Golden Path with GeneCards custom track

Promoters for CATSPERZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040647 809 401 HDGF ATF1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZHX2 REST

Genomic Location for CATSPERZ Gene

Chromosome:
11
Start:
64,300,391 bp from pter
End:
64,304,770 bp from pter
Size:
4,380 bases
Orientation:
Plus strand

Genomic View for CATSPERZ Gene

Genes around CATSPERZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CATSPERZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CATSPERZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATSPERZ Gene

Proteins for CATSPERZ Gene

  • Protein details for CATSPERZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTU4-TEX40_HUMAN
    Recommended name:
    Testis-expressed protein 40
    Protein Accession:
    Q9NTU4

    Protein attributes for CATSPERZ Gene

    Size:
    200 amino acids
    Molecular mass:
    22839 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CATSPERZ Gene

Post-translational modifications for CATSPERZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CATSPERZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CATSPERZ Gene

Domains & Families for CATSPERZ Gene

Protein Domains for CATSPERZ Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CATSPERZ: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CATSPERZ Gene

Function for CATSPERZ Gene

Molecular function for CATSPERZ Gene

UniProtKB/Swiss-Prot Function:
May be involved in late spermatogenesis.

Phenotypes for CATSPERZ Gene

MGI mutant phenotypes for CATSPERZ:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CATSPERZ: view

Animal Models for CATSPERZ Gene

MGI Knock Outs for CATSPERZ:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CATSPERZ Gene

Localization for CATSPERZ Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CATSPERZ gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for CATSPERZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0036128 CatSper complex ISS --
GO:0097228 sperm principal piece IDA 28226241
genes like me logo Genes that share ontologies with CATSPERZ: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CATSPERZ Gene

Pathways & Interactions for CATSPERZ Gene

SuperPathways for CATSPERZ Gene

No Data Available

Interacting Proteins for CATSPERZ Gene

Selected Interacting proteins: Q9NTU4-TEX40_HUMAN for CATSPERZ Gene via IID

Gene Ontology (GO) - Biological Process for CATSPERZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007140 male meiosis IEA,ISS --
GO:0007283 spermatogenesis ISS,IEA --
GO:0030154 cell differentiation IEA --
GO:0030317 flagellated sperm motility ISS --
GO:0048240 sperm capacitation ISS --
genes like me logo Genes that share ontologies with CATSPERZ: view

No data available for Pathways by source and SIGNOR curated interactions for CATSPERZ Gene

Drugs & Compounds for CATSPERZ Gene

No Compound Related Data Available

Transcripts for CATSPERZ Gene

mRNA/cDNA for CATSPERZ Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CATSPERZ Gene

No ASD Table

Relevant External Links for CATSPERZ Gene

GeneLoc Exon Structure for
CATSPERZ
ECgene alternative splicing isoforms for
CATSPERZ

Expression for CATSPERZ Gene

NURSA nuclear receptor signaling pathways regulating expression of CATSPERZ Gene:

CATSPERZ

Evidence on tissue expression from TISSUES for CATSPERZ Gene

  • Kidney(4.1)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CATSPERZ Gene

Orthologs for CATSPERZ Gene

This gene was present in the common ancestor of mammals.

Orthologs for CATSPERZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEX40 34 35
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia TEX40 34
  • 77.15 (n)
cow
(Bos Taurus)
Mammalia TEX40 34
  • 71.6 (n)
mouse
(Mus musculus)
Mammalia Tex40 34 35
  • 65.43 (n)
Catsperz 16
Species where no ortholog for CATSPERZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CATSPERZ Gene

ENSEMBL:
Gene Tree for CATSPERZ (if available)
TreeFam:
Gene Tree for CATSPERZ (if available)

Paralogs for CATSPERZ Gene

No data available for Paralogs for CATSPERZ Gene

Variants for CATSPERZ Gene

Sequence variations from dbSNP and Humsavar for CATSPERZ Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1001840955 -- 64,304,310(+) ACCAC(C/T)GCCCT intron-variant, upstream-variant-2KB
rs1001907775 -- 64,299,628(+) CGCTG(C/G)CCCGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1002963449 -- 64,299,254(+) TTGGG(A/G)TTTGA intron-variant, upstream-variant-2KB
rs1003444081 -- 64,302,908(+) TTTTA(G/T)TTTTT intron-variant
rs1003496263 -- 64,299,053(+) AAGAA(A/G)AAAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CATSPERZ Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
nsv357 CNV insertion 18451855
nsv469961 CNV loss 18288195
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for CATSPERZ Gene

Gene Damage Index Score: 3.96; 59.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CATSPERZ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CATSPERZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPERZ Gene

Disorders for CATSPERZ Gene

Relevant External Links for CATSPERZ

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CATSPERZ

No disorders were found for CATSPERZ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATSPERZ Gene

Publications for CATSPERZ Gene

  1. CatSperIP regulates the structural continuity of sperm Ca(2+) signaling domains and is required for normal fertility. (PMID: 28226241) Chung J.J. … Clapham D.E. (Elife 2017) 2 3 64
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  3. Low frequency of ESRRA-C11orf20 fusion gene in ovarian carcinomas. (PMID: 24504521) Micci F. … Heim S. (PLoS Biol. 2014) 3 64
  4. ESRRA-C11orf20 is a recurrent gene fusion in serous ovarian carcinoma. (PMID: 21949640) Salzman J. … Brown P.O. (PLoS Biol. 2011) 3 64
  5. A strategy for precise and large scale identification of core fucosylated glycoproteins. (PMID: 19139490) Jia W. … Qian X.H. (Mol. Cell. Proteomics 2009) 4 64

Products for CATSPERZ Gene

Sources for CATSPERZ Gene

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