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Aliases for CATSPERZ Gene

Aliases for CATSPERZ Gene

  • Catsper Channel Auxiliary Subunit Zeta 2 3 5
  • Testis-Expressed Protein 40 3 4
  • Testis Expressed 40 2 3
  • CatSper-Zeta 3 4
  • CatSperzeta 3 4
  • C11orf20 3 4
  • TEX40 3 4
  • Cation Channel Sperm-Associated Protein Subunit Zeta 3
  • Testis-Expressed Sequence 40 Protein 3
  • Chromosome 11 Open Reading Frame 20 2

External Ids for CATSPERZ Gene

Previous HGNC Symbols for CATSPERZ Gene

  • C11orf20
  • TEX40

Summaries for CATSPERZ Gene

GeneCards Summary for CATSPERZ Gene

CATSPERZ (Catsper Channel Auxiliary Subunit Zeta) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CATSPERZ Gene

  • Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract.

Additional gene information for CATSPERZ Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CATSPERZ Gene

Genomics for CATSPERZ Gene

Regulatory Elements for CATSPERZ Gene

Enhancers for CATSPERZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H064205 1.3 ENCODE dbSUPER 11.5 -92.8 -92796 4 HDGF PKNOX1 ATF1 ARNT SIN3A YY1 TCF12 ZNF766 ELK1 ZNF143 TRPT1 ZFPL1 PLCB3 SF1 TRMT112 ENSG00000257086 GPR137 BAD KCNK4-TEX40 KCNK4
GH11H064320 1.2 Ensembl ENCODE dbSUPER 12.2 +22.7 22729 5 MTA2 ZBTB2 NFXL1 ZIC2 ZKSCAN1 POLR2A EGR1 GLIS1 TARDBP PRDM1 PLCB3 LOC102723878 CATSPERZ ENSG00000207024 KCNK4-TEX40 KCNK4 BAD GPR137 ENSG00000257086 TRMT112
GH11H064347 0.8 ENCODE 11.5 +48.0 47991 1 BCOR KLF1 JUN CHD4 ZMYM3 MAX CEBPG POLR2A FOXK2 PATZ1 LOC102723878 MIR1237 PRDX5 TRMT112 ESRRA CATSPERZ ENSG00000207024 KCNK4 KCNK4-TEX40 BAD
GH11H064299 0.4 ENCODE 0.7 -1.0 -1008 0 CTCF EZH2 CATSPERZ ENSG00000207024
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CATSPERZ on UCSC Golden Path with GeneCards custom track

Promoters for CATSPERZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040647 809 401 HDGF ATF1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 REST PPARG

Genomic Location for CATSPERZ Gene

Chromosome:
11
Start:
64,300,391 bp from pter
End:
64,304,770 bp from pter
Size:
4,380 bases
Orientation:
Plus strand

Genomic View for CATSPERZ Gene

Genes around CATSPERZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CATSPERZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CATSPERZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATSPERZ Gene

Proteins for CATSPERZ Gene

  • Protein details for CATSPERZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTU4-CTSRZ_HUMAN
    Recommended name:
    Cation channel sperm-associated protein subunit zeta
    Protein Accession:
    Q9NTU4

    Protein attributes for CATSPERZ Gene

    Size:
    200 amino acids
    Molecular mass:
    22839 Da
    Quaternary structure:
    • Component of the CatSper complex.

neXtProt entry for CATSPERZ Gene

Post-translational modifications for CATSPERZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CATSPERZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CATSPERZ Gene

Domains & Families for CATSPERZ Gene

Gene Families for CATSPERZ Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CATSPERZ Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CATSPERZ: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CATSPERZ Gene

Function for CATSPERZ Gene

Molecular function for CATSPERZ Gene

UniProtKB/Swiss-Prot Function:
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract.

Phenotypes From GWAS Catalog for CATSPERZ Gene

Phenotypes for CATSPERZ Gene

genes like me logo Genes that share phenotypes with CATSPERZ: view

Animal Models for CATSPERZ Gene

MGI Knock Outs for CATSPERZ:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CATSPERZ
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CATSPERZ Gene

Localization for CATSPERZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for CATSPERZ Gene

Cell projection, cilium, flagellum membrane; Peripheral membrane protein. Note=Specifically located in the principal piece of sperm tail (PubMed:28226241). Although it does not contain a transmembrane domain, localizes with the CatSper complex at the flagellum membrane (PubMed:28226241). {ECO:0000269 PubMed:28226241}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CATSPERZ gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CATSPERZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0036128 CatSper complex ISS,IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with CATSPERZ: view

Pathways & Interactions for CATSPERZ Gene

SuperPathways for CATSPERZ Gene

No Data Available

Interacting Proteins for CATSPERZ Gene

Selected Interacting proteins: Q9NTU4-CTSRZ_HUMAN for CATSPERZ Gene via IID

Gene Ontology (GO) - Biological Process for CATSPERZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007140 male meiosis IEA,ISS --
GO:0007283 spermatogenesis ISS --
GO:0030154 cell differentiation IEA --
GO:0030317 flagellated sperm motility IEA,ISS --
GO:0048240 sperm capacitation ISS,IEA --
genes like me logo Genes that share ontologies with CATSPERZ: view

No data available for Pathways by source and SIGNOR curated interactions for CATSPERZ Gene

Drugs & Compounds for CATSPERZ Gene

No Compound Related Data Available

Transcripts for CATSPERZ Gene

mRNA/cDNA for CATSPERZ Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CATSPERZ
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CATSPERZ Gene

No ASD Table

Relevant External Links for CATSPERZ Gene

GeneLoc Exon Structure for
CATSPERZ
ECgene alternative splicing isoforms for
CATSPERZ

Expression for CATSPERZ Gene

NURSA nuclear receptor signaling pathways regulating expression of CATSPERZ Gene:

CATSPERZ

Evidence on tissue expression from TISSUES for CATSPERZ Gene

  • Kidney(4.1)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CATSPERZ Gene

Orthologs for CATSPERZ Gene

This gene was present in the common ancestor of mammals.

Orthologs for CATSPERZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEX40 33 34
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia TEX40 33
  • 77.15 (n)
cow
(Bos Taurus)
Mammalia TEX40 33
  • 71.6 (n)
mouse
(Mus musculus)
Mammalia Tex40 33 34
  • 65.43 (n)
Catsperz 16
Species where no ortholog for CATSPERZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CATSPERZ Gene

ENSEMBL:
Gene Tree for CATSPERZ (if available)
TreeFam:
Gene Tree for CATSPERZ (if available)

Paralogs for CATSPERZ Gene

No data available for Paralogs for CATSPERZ Gene

Variants for CATSPERZ Gene

Sequence variations from dbSNP and Humsavar for CATSPERZ Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1001840955 -- 64,304,310(+) ACCAC(C/T)GCCCT intron-variant, upstream-variant-2KB
rs1001907775 -- 64,299,628(+) CGCTG(C/G)CCCGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1002963449 -- 64,299,254(+) TTGGG(A/G)TTTGA intron-variant, upstream-variant-2KB
rs1003444081 -- 64,302,908(+) TTTTA(G/T)TTTTT intron-variant
rs1003496263 -- 64,299,053(+) AAGAA(A/G)AAAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CATSPERZ Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
nsv357 CNV insertion 18451855
nsv469961 CNV loss 18288195
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for CATSPERZ Gene

Gene Damage Index Score: 3.96; 59.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CATSPERZ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CATSPERZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPERZ Gene

Disorders for CATSPERZ Gene

Relevant External Links for CATSPERZ

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CATSPERZ

No disorders were found for CATSPERZ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATSPERZ Gene

Publications for CATSPERZ Gene

  1. 2+ (PMID: 28226241) Chung JJ … Clapham DE (eLife 2017) 2 3 4 60
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 60
  3. Low frequency of ESRRA-C11orf20 fusion gene in ovarian carcinomas. (PMID: 24504521) Micci F … Heim S (PLoS biology 2014) 3 60
  4. ESRRA-C11orf20 is a recurrent gene fusion in serous ovarian carcinoma. (PMID: 21949640) Salzman J … Brown PO (PLoS biology 2011) 3 60
  5. A strategy for precise and large scale identification of core fucosylated glycoproteins. (PMID: 19139490) Jia W … Qian XH (Molecular & cellular proteomics : MCP 2009) 4 60

Products for CATSPERZ Gene

Sources for CATSPERZ Gene

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