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Aliases for CATSPERG Gene

Aliases for CATSPERG Gene

  • Catsper Channel Auxiliary Subunit Gamma 2 3
  • C19orf15 3 4
  • Cation Channel Sperm-Associated Protein Subunit Gamma 3
  • Cation Channel, Sperm-Associated, Gamma 2
  • Chromosome 19 Open Reading Frame 15 2

External Ids for CATSPERG Gene

Previous HGNC Symbols for CATSPERG Gene

  • C19orf15

Previous GeneCards Identifiers for CATSPERG Gene

  • GC19P043521
  • GC19P038826
  • GC19P035274

Summaries for CATSPERG Gene

Entrez Gene Summary for CATSPERG Gene

  • CATSPERG is a subunit of the CATSPER (see CATSPER1; MIM 606389) sperm calcium channel, which is required for sperm hyperactivated motility and male fertility (Wang et al., 2009 [PubMed 19516020]).[supplied by OMIM, Jul 2010]

GeneCards Summary for CATSPERG Gene

CATSPERG (Catsper Channel Auxiliary Subunit Gamma) is a Protein Coding gene. Among its related pathways are Reproduction and Reproduction.

UniProtKB/Swiss-Prot for CATSPERG Gene

  • Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CATSPERG Gene

Genomics for CATSPERG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CATSPERG Gene

Start:
38,335,775 bp from pter
End:
38,370,949 bp from pter
Size:
35,175 bases
Orientation:
Plus strand

Genomic View for CATSPERG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CATSPERG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATSPERG Gene

No data available for Regulatory Elements for CATSPERG Gene

Proteins for CATSPERG Gene

  • Protein details for CATSPERG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRH7-CTSRG_HUMAN
    Recommended name:
    Cation channel sperm-associated protein subunit gamma
    Protein Accession:
    Q6ZRH7
    Secondary Accessions:
    • A6NEG6
    • Q659E1

    Protein attributes for CATSPERG Gene

    Size:
    1159 amino acids
    Molecular mass:
    133032 Da
    Quaternary structure:
    • Component of the CatSper complex.
    SequenceCaution:
    • Sequence=BAC87333.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CATSPERG Gene

Proteomics data for CATSPERG Gene at MOPED

Post-translational modifications for CATSPERG Gene

  • Glycosylation at Asn355 and Asn426
  • Modification sites at PhosphoSitePlus

Other Protein References for CATSPERG Gene

No data available for DME Specific Peptides for CATSPERG Gene

Domains for CATSPERG Gene

Protein Domains for CATSPERG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CATSPERG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZRH7

UniProtKB/Swiss-Prot:

CTSRG_HUMAN :
  • Q6ZRH7
Family:
  • Belongs to the CATSPERG family.
genes like me logo Genes that share domains with CATSPERG: view

No data available for Gene Families for CATSPERG Gene

Function for CATSPERG Gene

Molecular function for CATSPERG Gene

UniProtKB/Swiss-Prot Function: Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (By similarity).

Phenotypes for CATSPERG Gene

GenomeRNAi human phenotypes for CATSPERG:
genes like me logo Genes that share phenotypes with CATSPERG: view

Animal Model Products

CRISPR Products

miRNA for CATSPERG Gene

miRTarBase miRNAs that target CATSPERG

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for CATSPERG Gene

Localization for CATSPERG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CATSPERG Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CATSPERG Gene COMPARTMENTS Subcellular localization image for CATSPERG gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for CATSPERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0036128 CatSper complex ISS --
GO:0097228 sperm principal piece IEA --
genes like me logo Genes that share ontologies with CATSPERG: view

Pathways for CATSPERG Gene

SuperPathways for CATSPERG Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with CATSPERG: view

Pathways by source for CATSPERG Gene

3 Reactome pathways for CATSPERG Gene

Interacting Proteins for CATSPERG Gene

Gene Ontology (GO) - Biological Process for CATSPERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0007338 single fertilization TAS --
GO:0030154 cell differentiation IEA --
GO:0032504 multicellular organism reproduction TAS --
genes like me logo Genes that share ontologies with CATSPERG: view

Transcripts for CATSPERG Gene

Unigene Clusters for CATSPERG Gene

Catsper channel auxiliary subunit gamma:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CATSPERG

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CATSPERG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CATSPERG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - -
SP6:
SP7:
SP8:
SP9: -
SP10:

ExUns: 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b
SP1: - - -
SP2: - -
SP3: - - -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CATSPERG Gene

GeneLoc Exon Structure for
CATSPERG
ECgene alternative splicing isoforms for
CATSPERG

Expression for CATSPERG Gene

mRNA expression in normal human tissues for CATSPERG Gene

mRNA differential expression in normal tissues according to GTEx for CATSPERG Gene

This gene is overexpressed in Testis (25.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CATSPERG Gene

SOURCE GeneReport for Unigene cluster for CATSPERG Gene Hs.324335

genes like me logo Genes that share expressions with CATSPERG: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CATSPERG Gene

Orthologs for CATSPERG Gene

This gene was present in the common ancestor of chordates.

Orthologs for CATSPERG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CATSPERG 35
  • 99.29 (n)
  • 98.99 (a)
CATSPERG 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CATSPERG 35
  • 81.2 (n)
  • 73.02 (a)
CATSPERG 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CATSPERG 35
  • 81.72 (n)
  • 74.04 (a)
CATSPERG 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Catsperg1 35
  • 67.83 (n)
  • 56.8 (a)
Catsperg1 36
  • 55 (a)
OneToMany
Catsperg2 16
Catsperg2 36
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CATSPERG 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CATSPERG 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Catsperg1 35
  • 66.93 (n)
  • 56.07 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 41 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
Species with no ortholog for CATSPERG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CATSPERG Gene

ENSEMBL:
Gene Tree for CATSPERG (if available)
TreeFam:
Gene Tree for CATSPERG (if available)

Paralogs for CATSPERG Gene

genes like me logo Genes that share paralogs with CATSPERG: view

No data available for Paralogs for CATSPERG Gene

Variants for CATSPERG Gene

Sequence variations from dbSNP and Humsavar for CATSPERG Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs977620 -- 38,366,415(+) TGTGA(C/T)TGCAT intron-variant
rs1052375 -- 38,370,693(+) ATGCC(A/G)TCTCT synonymous-codon, reference
rs1060454 -- 38,359,780(+) ACCGG(A/G)GCTAT intron-variant, utr-variant-5-prime
rs1060455 -- 38,359,790(+) TGATC(C/T)GATGT intron-variant, utr-variant-5-prime
rs2041220 -- 38,335,544(+) AAAAA(A/T)ATATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CATSPERG Gene

Variant ID Type Subtype PubMed ID
nsv833822 CNV Loss 17160897
nsv911658 CNV Loss 21882294
esv22727 CNV Loss 19812545
esv2718532 CNV Deletion 23290073
nsv470140 CNV Gain 18288195
nsv911659 CNV Loss 21882294
nsv911660 CNV Gain 21882294
nsv833823 CNV Loss 17160897

Relevant External Links for CATSPERG Gene

HapMap Linkage Disequilibrium report
CATSPERG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPERG Gene

Disorders for CATSPERG Gene

No disorders were found for CATSPERG Gene.

No data available for UniProtKB/Swiss-Prot for CATSPERG Gene

Publications for CATSPERG Gene

  1. A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein. (PMID: 19516020) Wang H. … Ren D. (Biol. Reprod. 2009) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PMID: 22118674) Altun M. … Kessler B.M. (Chem. Biol. 2011) 3

Products for CATSPERG Gene

  • antibodies-online peptides for CATSPERG
  • antibodies-online antibodies for CATSPERG
  • antibodies-online kits for CATSPERG

Sources for CATSPERG Gene

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