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Aliases for CATSPERD Gene

Aliases for CATSPERD Gene

  • Catsper Channel Auxiliary Subunit Delta 2 3
  • Transmembrane Protein 146 2 3 4
  • CatSper-Delta 3 4
  • CatSperdelta 3 4
  • TMEM146 3 4

External Ids for CATSPERD Gene

Previous HGNC Symbols for CATSPERD Gene

  • TMEM146

Summaries for CATSPERD Gene

GeneCards Summary for CATSPERD Gene

CATSPERD (Catsper Channel Auxiliary Subunit Delta) is a Protein Coding gene. Among its related pathways are Reproduction. An important paralog of this gene is C1orf101.

UniProtKB/Swiss-Prot for CATSPERD Gene

  • Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CATSPERD Gene

Genomics for CATSPERD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CATSPERD Gene

Chromosome:
19
Start:
5,720,401 bp from pter
End:
5,778,734 bp from pter
Size:
58,334 bases
Orientation:
Plus strand

Genomic View for CATSPERD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CATSPERD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATSPERD Gene

No data available for Regulatory Elements for CATSPERD Gene

Proteins for CATSPERD Gene

  • Protein details for CATSPERD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XM0-CTSRD_HUMAN
    Recommended name:
    Cation channel sperm-associated protein subunit delta
    Protein Accession:
    Q86XM0
    Secondary Accessions:
    • Q6ZRP1

    Protein attributes for CATSPERD Gene

    Size:
    798 amino acids
    Molecular mass:
    90468 Da
    Quaternary structure:
    • Component of the CatSper complex.
    SequenceCaution:
    • Sequence=AAH43005.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CATSPERD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CATSPERD Gene

Proteomics data for CATSPERD Gene at MOPED

Post-translational modifications for CATSPERD Gene

  • Glycosylation at Asn 240, Asn 472, and Asn 538
  • Modification sites at PhosphoSitePlus

Other Protein References for CATSPERD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CATSPERD Gene

Domains & Families for CATSPERD Gene

Protein Domains for CATSPERD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CATSPERD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XM0

UniProtKB/Swiss-Prot:

CTSRD_HUMAN :
  • Belongs to the CATSPERD family.
Family:
  • Belongs to the CATSPERD family.
genes like me logo Genes that share domains with CATSPERD: view

No data available for Gene Families for CATSPERD Gene

Function for CATSPERD Gene

Molecular function for CATSPERD Gene

UniProtKB/Swiss-Prot Function:
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane (By similarity).

Gene Ontology (GO) - Molecular Function for CATSPERD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CATSPERD: view

Phenotypes for CATSPERD Gene

MGI mutant phenotypes for CATSPERD:
inferred from 1 alleles
GenomeRNAi human phenotypes for CATSPERD:
genes like me logo Genes that share phenotypes with CATSPERD: view

Animal Models for CATSPERD Gene

MGI Knock Outs for CATSPERD:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CATSPERD

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CATSPERD Gene

Localization for CATSPERD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CATSPERD Gene

Cell projection, cilium, flagellum membrane; Single-pass type I membrane protein. Note=Specifically located in the principal piece of sperm tail. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CATSPERD Gene COMPARTMENTS Subcellular localization image for CATSPERD gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for CATSPERD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0036128 CatSper complex ISS --
GO:0097228 sperm principal piece ISS --
genes like me logo Genes that share ontologies with CATSPERD: view

Pathways & Interactions for CATSPERD Gene

SuperPathways for CATSPERD Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with CATSPERD: view

Pathways by source for CATSPERD Gene

3 Reactome pathways for CATSPERD Gene

Gene Ontology (GO) - Biological Process for CATSPERD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis ISS --
GO:0007338 single fertilization TAS --
GO:0030317 sperm motility ISS --
GO:0032504 multicellular organism reproduction TAS --
genes like me logo Genes that share ontologies with CATSPERD: view

No data available for SIGNOR curated interactions for CATSPERD Gene

Drugs & Compounds for CATSPERD Gene

No Compound Related Data Available

Transcripts for CATSPERD Gene

mRNA/cDNA for CATSPERD Gene

Unigene Clusters for CATSPERD Gene

Catsper channel auxiliary subunit delta:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CATSPERD

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CATSPERD Gene

No ASD Table

Relevant External Links for CATSPERD Gene

GeneLoc Exon Structure for
CATSPERD
ECgene alternative splicing isoforms for
CATSPERD

Expression for CATSPERD Gene

mRNA expression in normal human tissues for CATSPERD Gene

mRNA differential expression in normal tissues according to GTEx for CATSPERD Gene

This gene is overexpressed in Testis (x39.8).

Protein differential expression in normal tissues from HIPED for CATSPERD Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CATSPERD Gene



SOURCE GeneReport for Unigene cluster for CATSPERD Gene Hs.631842

genes like me logo Genes that share expression patterns with CATSPERD: view

Protein tissue co-expression partners for CATSPERD Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CATSPERD Gene

Orthologs for CATSPERD Gene

This gene was present in the common ancestor of chordates.

Orthologs for CATSPERD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CATSPERD 35
  • 74.94 (n)
  • 64.94 (a)
CATSPERD 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CATSPERD 35
  • 76.97 (n)
  • 66.75 (a)
CATSPERD 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Catsperd 35
  • 61.91 (n)
  • 52.36 (a)
Catsperd 16
Catsperd 36
  • 49 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CATSPERD 35
  • 96.12 (n)
  • 94.78 (a)
rat
(Rattus norvegicus)
Mammalia Catsperd 35
  • 62.58 (n)
  • 52.88 (a)
oppossum
(Monodelphis domestica)
Mammalia CATSPERD 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CATSPERD 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
Species with no ortholog for CATSPERD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CATSPERD Gene

ENSEMBL:
Gene Tree for CATSPERD (if available)
TreeFam:
Gene Tree for CATSPERD (if available)

Paralogs for CATSPERD Gene

Paralogs for CATSPERD Gene

(19) SIMAP similar genes for CATSPERD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CATSPERD: view

Variants for CATSPERD Gene

Sequence variations from dbSNP and Humsavar for CATSPERD Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1026466 -- 5,775,326(+) gacct(C/G)cgtat intron-variant
rs1973115 -- 5,777,856(+) ggtaa(C/T)agagc intron-variant
rs2017303 -- 5,778,196(+) GAGAG(A/G)GACTC intron-variant
rs2050588 -- 5,753,105(-) cttaa(A/G)ttcag intron-variant
rs2290778 -- 5,776,190(+) AACAA(C/T)AATGC reference, synonymous-codon, utr-variant-3-prime

Variation tolerance for CATSPERD Gene

Residual Variation Intolerance Score: 96.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.32; 85.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CATSPERD Gene

HapMap Linkage Disequilibrium report
CATSPERD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CATSPERD Gene

Disorders for CATSPERD Gene

Relevant External Links for CATSPERD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CATSPERD
genes like me logo Genes that share disorders with CATSPERD: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATSPERD Gene

Publications for CATSPERD Gene

  1. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. (PMID: 21224844) Chung J.J. … Clapham D.E. (Nat Commun 2011) 2 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for CATSPERD Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CATSPERD
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CATSPERD
    • Block miRNA regulation of CATSPERD using miScript Target Protectors

    Sources for CATSPERD Gene

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