CATSPERD Gene
protein-coding GIFtS: 37
GCID: GC19P005720
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catsper channel auxiliary subunit delta(Previous name: transmembrane protein 146 )
(Previous symbol: TMEM146)
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Aliases
for CATSPERD gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Catsper Channel Auxiliary Subunit Delta1 2 | | CatSperdelta3 | | Transmembrane Protein 1461 2 3 | | Cation Channel Sperm-Associated Protein Subunit Delta2 | | TMEM1461 2 3 | | CatSper-Delta1 | | MGC395811 | | CatSperdelta3 | | CatSper-Delta1 | | |
Export aliases for CATSPERD gene to outside databases |
Summaries
for CATSPERD gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CTSRD_HUMAN, Q86XM0Function: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cellhyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channelinto the flagellar membrane (By similarity)
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Genomic Views
for CATSPERD gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CATSPERD
Other transcription factors
Search SABiosciences Chromatin IP Primers for CATSPERD
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CATSPERD |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3CATSPERD Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P005720: view genomic region
(about GC identifiers)
Start:
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5,720,688 bp from pter |
End:
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5,778,745 bp from pter |
Size:
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58,058 bases |
Orientation:
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plus strand |
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Proteins
for CATSPERD gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CTSRD_HUMAN, Q86XM0 (See
protein sequence)Recommended Name: Cation channel sperm-associated protein subunit delta precursor Size: 798 amino acids; 90468 Da
Subunit: Component of the CatSper complex (By similarity)
Subcellular location: Cell projection, cilium, flagellum membrane; Single-pass type I membrane protein (By similarity).Note=Specifically located in the principal piece of sperm tail (By similarity)
Caution: It is uncertain whether Met-1 or Met-5 is the initiator
Sequence caution: Sequence=AAH43005.2; Type=Erroneous initiation;
Secondary accessions: Q6ZRP1Alternative splicing: 2 isoforms: Q86XM0-1 Q86XM0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CATSPERD: NX_Q86XM0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86XM0
CATSPERD Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689997.3
ENSEMBL proteins: ENSP00000371037 ENSP00000371027
Human Recombinant Protein Products for CATSPERD:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CATSPERD for ontologies About GeneDecksing
CATSPERD Antibody Products:
Assay Products for CATSPERD: |
Protein
Domains /
Families
for CATSPERD gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q86XM0 UniProtKB/Swiss-Prot: CTSRD_HUMAN, Q86XM0Similarity: Belongs to the CATSPERD family |
Function
for CATSPERD gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CTSRD_HUMAN, Q86XM0Function: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cellhyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channelinto the flagellar membrane (By similarity)Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Catsperd):
CATSPERD for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Catsperdtm1.1Clph for CATSPERD
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPERD (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPERD (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for CATSPERD | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CATSPERD | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CATSPERD |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CATSPERD |
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Pathways & Interactions
for CATSPERD gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CATSPERD
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/36 Interacting proteins for CATSPERD (ENSP000003710374) via UniProtKB, MINT, STRING, and/or I2D (see all 36)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
CATSPERD for ontologies About GeneDecksing
|
Drugs & Compounds
for CATSPERD gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CATSPERD
Search CenterWatch for drugs/clinical trials and news about CATSPERD / CTSRD
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Transcripts
for CATSPERD gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CATSPERD gene: NM_152784.3 Unigene Cluster for CATSPERD: Catsper channel auxiliary subunit delta Hs.631842 [show with all ESTs]Unigene Representative Sequence: AK1280884 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381624(uc002mda.3) ENST00000309164 ENST00000448307 ENST00000381614
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPERD (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPERD (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for CATSPERD | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CATSPERD | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CATSPERD |
Additional cDNA sequence: AK128088.1 BC031233.1 BC043005.1 4 DOTS entries: DT.306012 DT.100746185 DT.101966014 DT.40229686 21 AceView cDNA sequences: BE672403 BE502510 BX101551 BC043005 AA601742 AA928626 AA907365 AA683412 BF929291 AI953218 BX508347 BI826374 NM_152784 BI458598 AK128088 BC031233 BI829431 BG773069 AW183238 BI562379 AI203106
GeneLoc Exon Structure
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Expression
for CATSPERD gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CATSPERD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTACCTCCC
About this image
See CATSPERD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CATSPERD
SOURCE GeneReport for Unigene cluster: Hs.631842
SABiosciences Custom PCR Arrays for CATSPERD
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CATSPERD
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CATSPERD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CATSPERD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CATSPERD | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CATSPERD |
Orthologs
for CATSPERD gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CATSPERD gene from 2/10 species (see all 10) About this table
ENSEMBL Gene Tree for CATSPERD (if available)
TreeFam Gene Tree for CATSPERD (if available) |
Paralogs
for CATSPERD gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CATSPERD gene
- C1orf1012
18/20 SIMAP similar genes for CATSPERD using alignment to 2 protein entries: CTSRD_HUMAN (see all proteins)
(see all similar genes):TMEM146 DUSP11 MST132 NCKAP1L ZRSR2 CASC4
COQ5 TUBA1C HC6 FLJ00047 LOC100996300 FP6778
SH2B3 pp12301 ATF1 PFKFB3 GEMIN6 SNRPF
CATSPERD for paralogs About GeneDecksing
|
Genomic Variants
for CATSPERD gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for CATSPERD (5720688 - 5778745 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CATSPERD: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CATSPERD |
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Disorders
/ Diseases
for CATSPERD gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CATSPERD gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CATSPERD gene integrated from 9 sources:
(articles sorted by number of sources associating them with CATSPERD) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel gene required for male fertility and function al CATSPER channel formation in spermatozoa. (PubMed id 21224844)1, 3 Chung J.J....Clapham D.E. (2011)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for CATSPERD gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CATSPERD gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing CATSPERD gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CATSPERD gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CATSPERD | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CATSPERD gene:
Search GeneIP for patents involving CATSPERD
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CATSPERD gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CATSPERD | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CATSPERD | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CATSPERD | | | OriGene Protein Over-expression Lysate for CATSPERD | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CATSPERD | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPERD | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPERD | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CATSPERD | | OriGene Custom Protein Services for CATSPERD | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CATSPERD | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CATSPERD | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CATSPERD | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CATSPERD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CATSPERD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CATSPERD |
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 | | | CATSPERD Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CATSPERD |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CATSPERD |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CATSPERD |
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