CATSPERB Gene
protein-coding GIFtS: 40
GCID: GC14M092047
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catsper channel auxiliary subunit beta(Previous names: chromosome 14 open reading frame 161, cation channel, sperm-associated,...)
(Previous symbol: C14orf161)
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Aliases
for CATSPERB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Catsper Channel Auxiliary Subunit Beta1 2 | | CatSper(Beta)1 | | C14orf1611 2 3 | | CatSper-Beta1 | | Cation Channel, Sperm-Associated, Beta1 2 | | Cation Channel Sperm-Associated Protein Subunit Beta2 | | FLJ142981 | | Cation Channel, Sperm Associated Beta2 | | Chromosome 14 Open Reading Frame 1611 | | CatSper-Beta1 |
Export aliases for CATSPERB gene to outside databasesPrevious GC identifers: GC14M091117 GC14M072223 |
Summaries
for CATSPERB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CTSRB_HUMAN, Q9H7T0Function: Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivationis needed for sperm motility which is essential late in the preparation of sperm for fertilization (By similarity)
|
Genomic Views
for CATSPERB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CATSPERB gene promoter:
TBP Tal-1 Tal-1beta E47 Evi-1 C/EBPalpha MEF-2A Chx10 aMEF-2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CATSPERB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CATSPERB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.12 Ensembl cytogenetic band: 14q32.12 HGNC cytogenetic band: 14q32.12CATSPERB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M092047: view genomic region
(about GC identifiers)
Start:
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92,047,040 bp from pter |
End:
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92,247,051 bp from pter |
Size:
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200,012 bases |
Orientation:
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minus strand |
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Proteins
for CATSPERB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CTSRB_HUMAN, Q9H7T0 (See
protein sequence)Recommended Name: Cation channel sperm-associated protein subunit beta Size: 1116 amino acids; 126924 Da
Subunit: Component of the CatSper complex (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A0AV51Alternative splicing: 2 isoforms: Q9H7T0-1 Q9H7T0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CATSPERB: NX_Q9H7T0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H7T0
CATSPERB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079040.2
ENSEMBL proteins: ENSP00000451083 ENSP00000256343 ENSP00000450878 ENSP00000452224 ENSP00000451455 ENSP00000451047
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CATSPERB for ontologies About GeneDecksing
CATSPERB Antibody Products:
Assay Products for CATSPERB: |
Protein
Domains /
Families
for CATSPERB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9H7T0 |
Function
for CATSPERB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CTSRB_HUMAN, Q9H7T0Function: Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivationis needed for sperm motility which is essential late in the preparation of sperm for fertilization (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPERB (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPERB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CATSPERB (NM_024764) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CATSPERB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CATSPERB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CATSPERB |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
CATSPERB for ontologies About GeneDecksing
|
Pathways & Interactions
for CATSPERB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CATSPERB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/36 Interacting proteins for CATSPERB (ENSP000002563434) via UniProtKB, MINT, STRING, and/or I2D (see all 36)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007283 | spermatogenesis |
IEA | -- | | GO:0030154 | cell differentiation |
IEA | -- |
CATSPERB for ontologies About GeneDecksing
|
Drugs & Compounds
for CATSPERB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CATSPERB
Search CenterWatch for drugs/clinical trials and news about CATSPERB / CTSRB
|
Transcripts
for CATSPERB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CATSPERB gene: NM_024764.2 Unigene Cluster for CATSPERB: Catsper channel auxiliary subunit beta Hs.131755 [show with all ESTs]Unigene Representative Sequence: AK1260348 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000557036 ENST00000256343(uc010aub.1 uc001xzs.1) ENST00000556429
ENST00000556901 ENST00000553329 ENST00000554560 ENST00000556661 ENST00000553676
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPERB (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPERB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CATSPERB (NM_024764) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CATSPERB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CATSPERB |
Additional cDNA sequence: AK024360.1 AK126034.1 BC016315.1 BC126214.1 BC126216.1 3 DOTS entries: DT.95177112 DT.203376 DT.91897227 24/168 AceView cDNA sequences (see all 168): AW294294 AI206955 AW605686 BQ778292 BU681698 AI910436 AI280362 AA909391 BE302146 BU676496 AA075405 AA360896 AI148628 AI151308 CF528740 BM840272 AA588755 AA456598 T56838 AI351894 CB153880 AI741162 AA361684 AI470643
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CATSPERB About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 26 | ^ | 27a | · | 27b |
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| SP1: | | | | | | | |
| SP2: | | | | | | |
ECgene alternative splicing isoforms for CATSPERB
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Expression
for CATSPERB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CATSPERB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGATCATAA
About this image
See CATSPERB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CATSPERB
SOURCE GeneReport for Unigene cluster: Hs.131755
SABiosciences Custom PCR Arrays for CATSPERB
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CATSPERB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CATSPERB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CATSPERB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CATSPERB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CATSPERB |
Orthologs
for CATSPERB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CATSPERB gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for CATSPERB (if available)
TreeFam Gene Tree for CATSPERB (if available) |
Paralogs
for CATSPERB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CATSPERB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CATSPERB (92047040 - 92247051 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CATSPERB
2 CNVs: 102011 35280
1 Indel: 102012 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for CATSPERB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 CATSPERB for disorders About MalaCards
CATSPERB for disorders About GeneDecksing
OMIM gene information: 611169
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: CATSPERB (1 document)
Export disorders for CATSPERB gene to outside databases
|
Publications
for CATSPERB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CATSPERB gene integrated from 9 sources:
(articles sorted by number of sources associating them with CATSPERB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- CatSperbeta, a novel transmembrane protein in the CatSper channel complex. (PubMed id 17478420)1, 3 Liu J....Ren D. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
- Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American w omen. (PubMed id 20164292)1 Koller D.L....Foroud T. (2010)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
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External Searches for CATSPERB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CATSPERB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CATSPERB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CATSPERB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CATSPERB | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CATSPERB gene:
Search GeneIP for patents involving CATSPERB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CATSPERB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CATSPERB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CATSPERB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CATSPERB | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CATSPERB | | OriGene 3'-UTR Clone for CATSPERB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPERB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPERB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CATSPERB | | OriGene Custom Protein Services for CATSPERB | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CATSPERB | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CATSPERB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CATSPERB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CATSPERB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CATSPERB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CATSPERB |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CATSPERB |
|  |  |  | | | | Search ThermoFisher Antibodies for CATSPERB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CATSPERB |
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