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Aliases for CATSPERB Gene

Aliases for CATSPERB Gene

  • Catsper Channel Auxiliary Subunit Beta 2 3
  • Cation Channel, Sperm-Associated, Beta 2 3
  • CatSper-Beta 3 4
  • C14orf161 3 4
  • Cation Channel, Sperm Associated Beta 3
  • Chromosome 14 Open Reading Frame 161 2
  • CatSper(Beta) 3

External Ids for CATSPERB Gene

Previous HGNC Symbols for CATSPERB Gene

  • C14orf161

Previous GeneCards Identifiers for CATSPERB Gene

  • GC14M091117
  • GC14M092047
  • GC14M072223

Summaries for CATSPERB Gene

GeneCards Summary for CATSPERB Gene

CATSPERB (Catsper Channel Auxiliary Subunit Beta) is a Protein Coding gene. Among its related pathways are Reproduction.

UniProtKB/Swiss-Prot for CATSPERB Gene

  • Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CATSPERB Gene

Genomics for CATSPERB Gene

Regulatory Elements for CATSPERB Gene

Genomic Location for CATSPERB Gene

Chromosome:
14
Start:
91,580,696 bp from pter
End:
91,780,707 bp from pter
Size:
200,012 bases
Orientation:
Minus strand

Genomic View for CATSPERB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CATSPERB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATSPERB Gene

Proteins for CATSPERB Gene

  • Protein details for CATSPERB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7T0-CTSRB_HUMAN
    Recommended name:
    Cation channel sperm-associated protein subunit beta
    Protein Accession:
    Q9H7T0
    Secondary Accessions:
    • A0AV51

    Protein attributes for CATSPERB Gene

    Size:
    1116 amino acids
    Molecular mass:
    126924 Da
    Quaternary structure:
    • Component of the CatSper complex.

    Alternative splice isoforms for CATSPERB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CATSPERB Gene

Proteomics data for CATSPERB Gene at MOPED

Post-translational modifications for CATSPERB Gene

  • Glycosylation at Asn 90, Asn 100, Asn 118, Asn 226, and Asn 321
  • Modification sites at PhosphoSitePlus

Other Protein References for CATSPERB Gene

Antibody Products

No data available for DME Specific Peptides for CATSPERB Gene

Domains & Families for CATSPERB Gene

Protein Domains for CATSPERB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CATSPERB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CATSPERB: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CATSPERB Gene

Function for CATSPERB Gene

Molecular function for CATSPERB Gene

UniProtKB/Swiss-Prot Function:
Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (By similarity).

Gene Ontology (GO) - Molecular Function for CATSPERB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CATSPERB: view

Phenotypes for CATSPERB Gene

GenomeRNAi human phenotypes for CATSPERB:
genes like me logo Genes that share phenotypes with CATSPERB: view

Animal Model Products

CRISPR Products

miRNA for CATSPERB Gene

miRTarBase miRNAs that target CATSPERB

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CATSPERB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CATSPERB Gene

Localization for CATSPERB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CATSPERB Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CATSPERB Gene COMPARTMENTS Subcellular localization image for CATSPERB gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for CATSPERB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005929 cilium IBA --
GO:0036128 CatSper complex ISS --
genes like me logo Genes that share ontologies with CATSPERB: view

Pathways & Interactions for CATSPERB Gene

SuperPathways for CATSPERB Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with CATSPERB: view

Pathways by source for CATSPERB Gene

3 Reactome pathways for CATSPERB Gene

Interacting Proteins for CATSPERB Gene

Gene Ontology (GO) - Biological Process for CATSPERB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007338 single fertilization TAS --
GO:0032504 multicellular organism reproduction TAS --
GO:0035036 sperm-egg recognition TAS --
GO:0048240 sperm capacitation IBA --
genes like me logo Genes that share ontologies with CATSPERB: view

No data available for SIGNOR curated interactions for CATSPERB Gene

Drugs & Compounds for CATSPERB Gene

No Compound Related Data Available

Transcripts for CATSPERB Gene

Unigene Clusters for CATSPERB Gene

Catsper channel auxiliary subunit beta:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CATSPERB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CATSPERB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1:
SP2: -

ExUns: 26 ^ 27a · 27b
SP1:
SP2:

Relevant External Links for CATSPERB Gene

GeneLoc Exon Structure for
CATSPERB
ECgene alternative splicing isoforms for
CATSPERB

Expression for CATSPERB Gene

mRNA expression in normal human tissues for CATSPERB Gene

mRNA differential expression in normal tissues according to GTEx for CATSPERB Gene

This gene is overexpressed in Pancreas (x17.1), Artery - Aorta (x4.7), and Minor Salivary Gland (x4.4).

Protein differential expression in normal tissues from HIPED for CATSPERB Gene

This gene is overexpressed in Plasma (22.3), Ovary (11.4), Adipocyte (10.0), NK cells (7.5), and Prostate (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CATSPERB Gene



SOURCE GeneReport for Unigene cluster for CATSPERB Gene Hs.131755

genes like me logo Genes that share expression patterns with CATSPERB: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CATSPERB Gene

Orthologs for CATSPERB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CATSPERB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CATSPERB 35
  • 81.35 (n)
  • 71.39 (a)
CATSPERB 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CATSPERB 35
  • 81.38 (n)
  • 73.35 (a)
CATSPERB 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Catsperb 35
  • 70.02 (n)
  • 56.88 (a)
Catsperb 16
Catsperb 36
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CATSPERB 35
  • 99.4 (n)
  • 98.84 (a)
CATSPERB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910102 35
  • 67.31 (n)
  • 55.13 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CATSPERB 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CATSPERB 36
  • 42 (a)
OneToOne
Species with no ortholog for CATSPERB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CATSPERB Gene

ENSEMBL:
Gene Tree for CATSPERB (if available)
TreeFam:
Gene Tree for CATSPERB (if available)

Paralogs for CATSPERB Gene

No data available for Paralogs for CATSPERB Gene

Variants for CATSPERB Gene

Sequence variations from dbSNP and Humsavar for CATSPERB Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1743154 -- 91,612,067(-) AAAAG(A/G)AAGAA intron-variant
rs2093366 -- 91,604,755(-) TGAAC(A/C)TGACT intron-variant
rs2093367 -- 91,604,754(-) GAACA(C/T)GACTG intron-variant
rs2104139 -- 91,604,903(-) CAGGT(G/T)AAGAC intron-variant
rs3841481 -- 91,636,716(-) GAACA(-/C)GTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CATSPERB Gene

Variant ID Type Subtype PubMed ID
esv2589440 CNV Deletion 19546169
nsv1396 CNV Insertion 18451855
esv1003307 CNV Insertion 20482838
esv2430078 CNV Insertion 19546169
esv267410 CNV Insertion 20981092
esv273550 CNV Insertion 20981092
esv1421109 CNV Insertion 17803354

Variation tolerance for CATSPERB Gene

Residual Variation Intolerance Score: 4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.47; 71.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CATSPERB Gene

HapMap Linkage Disequilibrium report
CATSPERB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPERB Gene

Disorders for CATSPERB Gene

Relevant External Links for CATSPERB

Genetic Association Database (GAD)
CATSPERB
Human Genome Epidemiology (HuGE) Navigator
CATSPERB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CATSPERB
genes like me logo Genes that share disorders with CATSPERB: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATSPERB Gene

Publications for CATSPERB Gene

  1. CatSperbeta, a novel transmembrane protein in the CatSper channel complex. (PMID: 17478420) Liu J. … Ren D. (J. Biol. Chem. 2007) 2 67
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 67
  3. Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women. (PMID: 20164292) Koller D.L. … Foroud T. (J. Clin. Endocrinol. Metab. 2010) 67
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for CATSPERB Gene

Sources for CATSPERB Gene

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