Aliases for CATSPERB Gene
Aliases for CATSPERB Gene
- Cation Channel Sperm Associated Auxiliary Subunit Beta 2 3 5
- Catsper Channel Auxiliary Subunit Beta 2 3
- CatSper-Beta 3 4
- C14orf161 3 4
- Cation Channel Sperm-Associated Protein Subunit Beta 3
- Cation Channel, Sperm-Associated, Beta 2
- Cation Channel, Sperm Associated Beta 3
- Chromosome 14 Open Reading Frame 161 2
- CatSper(Beta) 3
External Ids for CATSPERB Gene
- HGNC: 20500
- Entrez Gene: 79820
- Ensembl: ENSG00000133962
- OMIM: 611169
- UniProtKB: Q9H7T0
Previous HGNC Symbols for CATSPERB Gene
- C14orf161
Previous GeneCards Identifiers for CATSPERB Gene
- GC14M091117
- GC14M092047
- GC14M072223
Summaries for CATSPERB Gene
GeneCards Summary for CATSPERB Gene
CATSPERB (Cation Channel Sperm Associated Auxiliary Subunit Beta) is a Protein Coding gene. Among its related pathways are Fertilization.
UniProtKB/Swiss-Prot for CATSPERB Gene
-
Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CATSPERB Gene
Genomics for CATSPERB Gene
Regulatory Elements for CATSPERB Gene
- Transcription factor binding sites by QIAGEN in the CATSPERB gene promoter:
Regulatory Element Products
Genomic Location for CATSPERB Gene
- Chromosome:
- 14
- Start:
- 91,580,696 bp from pter
- End:
- 91,780,707 bp from pter
- Size:
- 200,012 bases
- Orientation:
- Minus strand
Genomic View for CATSPERB Gene
- Cytogenetic band:
-
- 14q32.12 by Ensembl
- 14q32.12 by Entrez Gene
- 14q32.12 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CATSPERB Gene
Proteins for CATSPERB Gene
-
Protein details for CATSPERB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H7T0-CTSRB_HUMAN
- Recommended name:
- Cation channel sperm-associated protein subunit beta
- Protein Accession:
- Q9H7T0
- A0AV51
Protein attributes for CATSPERB Gene
- Size:
- 1116 amino acids
- Molecular mass:
- 126924 Da
- Quaternary structure:
-
- Component of the CatSper complex.
Protein Expression for CATSPERB Gene
Post-translational modifications for CATSPERB Gene
Other Protein References for CATSPERB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CATSPERB
-
Abcam antibodies for CATSPERB
- Invitrogen Antibodies for CATSPERB
- antibodies-online Antibodies for CATSPERB: See all 3
- GeneTex CATSPERB antibody for CATSPERB
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CATSPERB
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- Novus Biologicals proteins for CATSPERB
- Search GeneTex for Proteins for CATSPERB
Assay Products
- antibodies-online Kits for CATSPERB: See all 3
No data available for DME Specific Peptides for CATSPERB Gene
Domains & Families for CATSPERB Gene
Gene Families for CATSPERB Gene
Protein Domains for CATSPERB Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CATSPERB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CATSPERB Gene
Function for CATSPERB Gene
Molecular function for CATSPERB Gene
- UniProtKB/Swiss-Prot Function:
- Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (By similarity).
Phenotypes for CATSPERB Gene
- GenomeRNAi human phenotypes for CATSPERB:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CATSPERB
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CATSPERB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CATSPERB gene
- Search ViGene Biosciences for CATSPERB
CRISPR Products
-
OriGene CRISPR knockouts for CATSPERB
-
Santa Cruz Biotechnology (SCBT) CRISPR for CATSPERB
- GenScript: Design CRISPR guide RNA sequences for CATSPERB
miRNA for CATSPERB Gene
- miRTarBase miRNAs that target CATSPERB
miRNA Products
- Search ViGene Biosciences for CATSPERB
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CATSPERB
- Browse OriGene Inhibitory RNA Products For CATSPERB
-
ViGene Biosciences ready-to-package AAV shRNAs for CATSPERB gene
Clone Products
-
OriGene ORF clones in human for CATSPERB
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CATSPERB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CATSPERB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CATSPERB
-
ViGene Biosciences adenoviral particle packaged cDNA for CATSPERB gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CATSPERB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CATSPERB gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CATSPERB Gene
Localization for CATSPERB Gene
Subcellular locations from UniProtKB/Swiss-Prot for CATSPERB Gene
- Membrane; Multi-pass membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005929 | cilium | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0036128 | CatSper complex | IEA,ISS | -- |
Pathways & Interactions for CATSPERB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Fertilization |
1.00
1.00
|
|
Pathways by source for CATSPERB Gene
3 Reactome pathways for CATSPERB Gene
Interacting Proteins for CATSPERB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007283 | spermatogenesis | IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
| GO:0032570 | response to progesterone | TAS | -- |
| GO:0035036 | sperm-egg recognition | TAS | -- |
No data available for SIGNOR curated interactions for CATSPERB Gene
Transcripts for CATSPERB Gene
mRNA/cDNA for CATSPERB Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (168) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CATSPERB Gene
CRISPR Products
-
OriGene CRISPR knockouts for CATSPERB
-
Santa Cruz Biotechnology (SCBT) CRISPR for CATSPERB
- GenScript: Design CRISPR guide RNA sequences for CATSPERB
miRNA Products
- Search ViGene Biosciences for CATSPERB
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CATSPERB
- Browse OriGene Inhibitory RNA Products For CATSPERB
-
ViGene Biosciences ready-to-package AAV shRNAs for CATSPERB gene
Clone Products
-
OriGene ORF clones in human for CATSPERB
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CATSPERB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CATSPERB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - |
| ExUns: | 26 | ^ | 27a | · | 27b |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: |
Expression for CATSPERB Gene
mRNA differential expression in normal tissues according to GTEx for CATSPERB Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CATSPERB Gene
NURSA nuclear receptor signaling pathways regulating expression of CATSPERB Gene:
CATSPERBSOURCE GeneReport for Unigene cluster for CATSPERB Gene:
Hs.131755Primer Products
-
OriGene qPCR primer pairs for CATSPERB
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CATSPERB Gene
Orthologs for CATSPERB Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CATSPERB 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CATSPERB 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CATSPERB 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Catsperb 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100910102 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CATSPERB 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CATSPERB 35 |
|
OneToOne |
- Species where no ortholog for CATSPERB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CATSPERB Gene
Pseudogenes.org Pseudogenes for CATSPERB Gene
No data available for Paralogs for CATSPERB Gene
Variants for CATSPERB Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000013640 | -- | 91,606,821(+) | AAGAT(A/G)GGGTA | intron-variant | |
| rs1000014627 | -- | 91,724,488(+) | TTGCT(C/G)TCATG | intron-variant | |
| rs1000049991 | -- | 91,697,557(+) | GTATA(C/T)GGAGA | intron-variant | |
| rs1000061191 | -- | 91,727,574(+) | CAAAG(C/T)ACTTT | intron-variant | |
| rs1000082789 | -- | 91,646,270(+) | CCCTG(C/T)ATCGA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1003307 | CNV | insertion | 20482838 |
| esv1421109 | CNV | insertion | 17803354 |
| esv2430078 | CNV | insertion | 19546169 |
| esv2589440 | CNV | deletion | 19546169 |
| esv3581388 | CNV | loss | 25503493 |
| esv3635327 | CNV | gain | 21293372 |
| nsv1396 | CNV | insertion | 18451855 |
| nsv480161 | CNV | novel sequence insertion | 20440878 |
| nsv480224 | CNV | novel sequence insertion | 20440878 |
| nsv480894 | CNV | novel sequence insertion | 20440878 |
| nsv481336 | CNV | novel sequence insertion | 20440878 |
| nsv974365 | CNV | duplication | 23825009 |
Relevant External Links for CATSPERB Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CATSPERB
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPERB Gene
Disorders for CATSPERB Gene
Relevant External Links for CATSPERB
No disorders were found for CATSPERB Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATSPERB Gene
Publications for CATSPERB Gene
- CatSperbeta, a novel transmembrane protein in the CatSper channel complex. (PMID: 17478420) Liu J. … Ren D. (J. Biol. Chem. 2007) 2 3 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women. (PMID: 20164292) Koller D.L. … Foroud T. (J. Clin. Endocrinol. Metab. 2010) 3 64
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 64
Products for CATSPERB Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CATSPERB
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- OriGene qPCR primer pairs for CATSPERB
- OriGene CRISPR knockouts for CATSPERB
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- GenScript: Design CRISPR guide RNA sequences for CATSPERB
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for CATSPERB
- Novus Biologicals proteins for CATSPERB
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for CATSPERB: See all 3
- antibodies-online Kits for CATSPERB: See all 3
- Search antibodies-online for proteins
- Search antibodies-online for peptides
- GeneTex CATSPERB antibody for CATSPERB
- Search GeneTex for Proteins for CATSPERB
- ViGene Biosciences adenoviral particle packaged cDNA for CATSPERB gene
- ViGene Biosciences lentiviral particle packaged cDNA for CATSPERB gene
- ViGene Biosciences ready-to-package AAV shRNAs for CATSPERB gene
- Search ViGene Biosciences for CATSPERB
- Horizon Cell Lines for CATSPERB
- Cyagen custom Knockout/knockin (KOKI) mouse models for CATSPERB
- VectorBuilder custom plasmid, inducible vectors for CATSPERB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CATSPERB
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CATSPERB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




