External Ids for CATSPER4 Gene
Previous GeneCards Identifiers for CATSPER4 Gene
GeneCards Summary for CATSPER4 Gene
CATSPER4 (Cation Channel, Sperm Associated 4) is a Protein Coding gene. Among its related pathways are Reproduction. GO annotations related to this gene include ion channel activity and calcium activated cation channel activity. An important paralog of this gene is CATSPER3.
UniProtKB/Swiss-Prot for CATSPER4 Gene
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.