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Aliases for CATSPER4 Gene

Aliases for CATSPER4 Gene

  • Cation Channel, Sperm Associated 4 2 3
  • CatSper4 4

External Ids for CATSPER4 Gene

Summaries for CATSPER4 Gene

GeneCards Summary for CATSPER4 Gene

CATSPER4 (Cation Channel, Sperm Associated 4) is a Protein Coding gene. Among its related pathways are Reproduction and Reproduction. GO annotations related to this gene include calcium channel activity and calcium activated cation channel activity. An important paralog of this gene is CATSPER3.

UniProtKB/Swiss-Prot for CATSPER4 Gene

  • Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.

Gene Wiki entry for CATSPER4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CATSPER4 Gene

Genomics for CATSPER4 Gene

Genomic Location for CATSPER4 Gene

Start:
26,190,561 bp from pter
End:
26,202,968 bp from pter
Size:
12,408 bases
Orientation:
Plus strand

Genomic View for CATSPER4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CATSPER4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATSPER4 Gene

Regulatory Elements for CATSPER4 Gene

Proteins for CATSPER4 Gene

  • Protein details for CATSPER4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTX7-CTSR4_HUMAN
    Recommended name:
    Cation channel sperm-associated protein 4
    Protein Accession:
    Q7RTX7
    Secondary Accessions:
    • A1A4W6
    • Q5VY71

    Protein attributes for CATSPER4 Gene

    Size:
    472 amino acids
    Molecular mass:
    54092 Da
    Quaternary structure:
    • Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the CatSper complex. Interacts with CATSPER1 (By similarity).
    SequenceCaution:
    • Sequence=AAI28139.1; Type=Frameshift; Positions=21; Evidence={ECO:0000305}; Sequence=CAH71538.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CATSPER4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CATSPER4 Gene

Proteomics data for CATSPER4 Gene at MOPED

Post-translational modifications for CATSPER4 Gene

No Post-translational modifications

Other Protein References for CATSPER4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CATSPER4 Gene

Domains for CATSPER4 Gene

Gene Families for CATSPER4 Gene

HGNC:
  • CATSPER :Voltage-gated ion channels / Cation channels, sperm associated
IUPHAR :

Protein Domains for CATSPER4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CATSPER4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTX7

UniProtKB/Swiss-Prot:

CTSR4_HUMAN
Family:
  • Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.:
    • Q7RTX7
genes like me logo Genes that share domains with CATSPER4: view

Function for CATSPER4 Gene

Molecular function for CATSPER4 Gene

UniProtKB/Swiss-Prot Function: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.

Gene Ontology (GO) - Molecular Function for CATSPER4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005227 calcium activated cation channel activity IEA --
GO:0005245 voltage-gated calcium channel activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CATSPER4: view

Phenotypes for CATSPER4 Gene

MGI mutant phenotypes for CATSPER4:
inferred from 2 alleles
genes like me logo Genes that share phenotypes with CATSPER4: view

Animal Models for CATSPER4 Gene

MGI Knock Outs for CATSPER4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CATSPER4 Gene

Localization for CATSPER4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CATSPER4 Gene

Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CATSPER4 Gene COMPARTMENTS Subcellular localization image for CATSPER4 gene
Compartment Confidence
plasma membrane 4
peroxisome 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CATSPER4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0036128 CatSper complex ISS --
GO:0097228 sperm principal piece IEA --
genes like me logo Genes that share ontologies with CATSPER4: view

Pathways for CATSPER4 Gene

SuperPathways for CATSPER4 Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with CATSPER4: view

Pathways by source for CATSPER4 Gene

3 Reactome pathways for CATSPER4 Gene

Interacting Proteins for CATSPER4 Gene

Gene Ontology (GO) - Biological Process for CATSPER4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006814 sodium ion transport IEA --
GO:0007275 multicellular organismal development IEA --
GO:0007338 single fertilization TAS --
GO:0030317 sperm motility IBA --
genes like me logo Genes that share ontologies with CATSPER4: view

Compounds for CATSPER4 Gene

(1) HMDB Compounds for CATSPER4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(6) IUPHAR Ligand for CATSPER4 Gene

Ligand Type Action Affinity Pubmed IDs
mibefradil Pore Blocker Antagonist 6.8
PGF1alpha Activator Full agonist 6.3
PGE1 Activator Full agonist 6.3
NNC55-0396 Pore Blocker Inhibition 5.7
progesterone Pore Blocker Inhibition 5.3
PGE2 Agonist Full agonist 4.5
genes like me logo Genes that share compounds with CATSPER4: view

Transcripts for CATSPER4 Gene

mRNA/cDNA for CATSPER4 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CATSPER4 Gene

Cation channel, sperm associated 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CATSPER4 Gene

No ASD Table

Relevant External Links for CATSPER4 Gene

GeneLoc Exon Structure for
CATSPER4
ECgene alternative splicing isoforms for
CATSPER4

Expression for CATSPER4 Gene

mRNA expression in normal human tissues for CATSPER4 Gene

mRNA differential expression in normal tissues according to GTEx for CATSPER4 Gene

This gene is overexpressed in Testis (47.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CATSPER4 Gene

SOURCE GeneReport for Unigene cluster for CATSPER4 Gene Hs.123532

mRNA Expression by UniProt/SwissProt for CATSPER4 Gene

Q7RTX7-CTSR4_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expressions with CATSPER4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CATSPER4 Gene

Orthologs for CATSPER4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CATSPER4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CATSPER4 35
  • 99.64 (n)
  • 99.78 (a)
CATSPER4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CATSPER4 35
  • 83.62 (n)
  • 77.14 (a)
CATSPER4 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CATSPER4 35
  • 82.81 (n)
  • 76.56 (a)
CATSPER4 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Catsper4 35
  • 77.7 (n)
  • 72.66 (a)
Catsper4 16
Catsper4 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CATSPER4 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CATSPER4 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Catsper4 35
  • 77.5 (n)
  • 74.14 (a)
lizard
(Anolis carolinensis)
Reptilia CATSPER4 36
  • 49 (a)
OneToOne
Species with no ortholog for CATSPER4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CATSPER4 Gene

ENSEMBL:
Gene Tree for CATSPER4 (if available)
TreeFam:
Gene Tree for CATSPER4 (if available)

Paralogs for CATSPER4 Gene

Paralogs for CATSPER4 Gene

Selected SIMAP similar genes for CATSPER4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CATSPER4: view

Variants for CATSPER4 Gene

Sequence variations from dbSNP and Humsavar for CATSPER4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs869139 -- 26,201,208(+) TTCCT(C/T)CCATC intron-variant
rs1815517 -- 26,201,942(-) GGAGG(C/T)CAAGG intron-variant
rs1889755 -- 26,201,318(+) CCCTG(A/C)GGCCT intron-variant
rs1889756 -- 26,201,319(+) CCTGA(A/G)GCCTT intron-variant
rs4659412 -- 26,191,979(+) GTCAC(C/T)ACAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CATSPER4 Gene

Variant ID Type Subtype PubMed ID
dgv201n71 CNV Gain 21882294

Relevant External Links for CATSPER4 Gene

HapMap Linkage Disequilibrium report
CATSPER4
Human Gene Mutation Database (HGMD)
CATSPER4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPER4 Gene

Disorders for CATSPER4 Gene

Relevant External Links for CATSPER4

Genetic Association Database (GAD)
CATSPER4
Human Genome Epidemiology (HuGE) Navigator
CATSPER4
genes like me logo Genes that share disorders with CATSPER4: view

No data available for UniProtKB/Swiss-Prot for CATSPER4 Gene

Publications for CATSPER4 Gene

  1. Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis. (PMID: 12932298) Lobley A. … Michalovich D. (Reprod. Biol. Endocrinol. 2003) 2 3 4 23
  2. International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. (PMID: 16382101) Clapham D.E. … Garbers D.L. (Pharmacol. Rev. 2005) 2 3
  3. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. (PMID: 17227845) Qi H. … Clapham D.E. (Proc. Natl. Acad. Sci. U.S.A. 2007) 2 3
  4. Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. (PMID: 19343178) Soranzo N. … Deloukas P. (PLoS Genet. 2009) 3 48
  5. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 48

Products for CATSPER4 Gene

Sources for CATSPER4 Gene

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