Aliases for CATSPER4 Gene
Aliases for CATSPER4 Gene
External Ids for CATSPER4 Gene
- HGNC: 23220
- Entrez Gene: 378807
- Ensembl: ENSG00000188782
- OMIM: 609121
- UniProtKB: Q7RTX7
Previous GeneCards Identifiers for CATSPER4 Gene
- GC00U913195
- GC01U900722
- GC01P026121
- GC01P026389
- GC01P026517
- GC01P024771
Summaries for CATSPER4 Gene
GeneCards Summary for CATSPER4 Gene
CATSPER4 (Cation Channel Sperm Associated 4) is a Protein Coding gene. Among its related pathways are Fertilization. GO annotations related to this gene include ion channel activity and calcium activated cation channel activity. An important paralog of this gene is CATSPER2.
UniProtKB/Swiss-Prot for CATSPER4 Gene
-
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CATSPER4 Gene
Genomics for CATSPER4 Gene
Regulatory Elements for CATSPER4 Gene
Enhancers for CATSPER4 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CATSPER4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CATSPER4 gene promoter:
Regulatory Element Products
Genomic Location for CATSPER4 Gene
- Chromosome:
- 1
- Start:
- 26,190,561 bp from pter
- End:
- 26,202,968 bp from pter
- Size:
- 12,408 bases
- Orientation:
- Plus strand
Genomic View for CATSPER4 Gene
Genes around CATSPER4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.11 by Ensembl
- 1p36.11 by Entrez Gene
- 1p36.11 by HGNC
CATSPER4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CATSPER4 Gene
Proteins for CATSPER4 Gene
-
Protein details for CATSPER4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7RTX7-CTSR4_HUMAN
- Recommended name:
- Cation channel sperm-associated protein 4
- Protein Accession:
- Q7RTX7
- A1A4W6
- Q5VY71
Protein attributes for CATSPER4 Gene
- Size:
- 472 amino acids
- Molecular mass:
- 54092 Da
- Quaternary structure:
-
- Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the CatSper complex. Interacts with CATSPER1 (By similarity).
- SequenceCaution:
-
- Sequence=AAI28139.1; Type=Frameshift; Positions=21; Evidence={ECO:0000305}; Sequence=CAH71538.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for CATSPER4 Gene
Post-translational modifications for CATSPER4 Gene
Other Protein References for CATSPER4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CATSPER4
- Novus Biologicals Antibodies for CATSPER4
-
Abcam antibodies for CATSPER4
- Invitrogen Antibodies for CATSPER4
- antibodies-online Antibodies for CATSPER4: See all 15
- Search GeneTex for Antibodies for CATSPER4
Protein Products
-
OriGene Purified Proteins for CATSPER4
- Search Origene for MassSpec and Protein Over-expression Lysates for CATSPER4
- Origene Custom Protein Services for CATSPER4
- Search GeneTex for Proteins for CATSPER4
Assay Products
- antibodies-online Kits for CATSPER4: See all 3
No data available for DME Specific Peptides for CATSPER4 Gene
Domains & Families for CATSPER4 Gene
Gene Families for CATSPER4 Gene
- HGNC:
- IUPHAR :
Protein Domains for CATSPER4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CATSPER4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7RTX7UniProtKB/Swiss-Prot:
CTSR4_HUMAN :- Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.
- Family:
-
- Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.
Function for CATSPER4 Gene
Molecular function for CATSPER4 Gene
- UniProtKB/Swiss-Prot EnzymeRegulation:
- The CatSper calcium channel is indirectly activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2 (PubMed:21412338, PubMed:21412339, PubMed:26989199). The CatSper calcium channel is directly inhibited by endocannabinoid 2-arachidonoylglycerol (2AG) (PubMed:26989199). Indirect activation by progesterone takes place via the following mechanism: progesterone binds and activates the acylglycerol lipase ABHD2, which in turn mediates hydrolysis of 2AG inhibitor, relieving inhibition of the CatSper channel (PubMed:26989199). The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers (PubMed:21412338, PubMed:21412339). Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH (PubMed:21412338, PubMed:21412339).
- UniProtKB/Swiss-Prot Function:
- Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005216 | ion channel activity | IEA | -- |
| GO:0005227 | calcium activated cation channel activity | IEA | -- |
| GO:0005244 | voltage-gated ion channel activity | IEA | -- |
| GO:0005245 | voltage-gated calcium channel activity | IEA | -- |
| GO:0005262 | calcium channel activity | IEA | -- |
Phenotypes for CATSPER4 Gene
- MGI mutant phenotypes for CATSPER4:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CATSPER4:
Animal Model Products
-
Taconic Biosciences Mouse Models for CATSPER4
- Cyagen custom Knockout/knockin (KOKI) mouse models for CATSPER4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CATSPER4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CATSPER4 gene
- Search ViGene Biosciences for CATSPER4
CRISPR Products
-
OriGene CRISPR knockouts for CATSPER4
-
Santa Cruz Biotechnology (SCBT) CRISPR for CATSPER4
- GenScript: Design CRISPR guide RNA sequences for CATSPER4
miRNA for CATSPER4 Gene
- miRTarBase miRNAs that target CATSPER4
-
- hsa-mir-6772-3p (MIRT609565)
- hsa-mir-502-5p (MIRT609566)
- hsa-mir-7111-3p (MIRT609567)
- hsa-mir-7110-3p (MIRT609568)
- hsa-mir-6845-3p (MIRT609569)
- hsa-mir-1915-5p (MIRT609570)
- hsa-mir-6841-3p (MIRT609571)
- hsa-mir-6769b-3p (MIRT609572)
- hsa-mir-4723-3p (MIRT609573)
- hsa-mir-3183 (MIRT609574)
- hsa-mir-660-3p (MIRT609575)
- hsa-mir-5193 (MIRT609576)
- hsa-mir-338-3p (MIRT609577)
- hsa-mir-4530 (MIRT609578)
- hsa-mir-5196-3p (MIRT609579)
- hsa-mir-5586-5p (MIRT609580)
miRNA Products
- Search ViGene Biosciences for CATSPER4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CATSPER4
- Browse OriGene Inhibitory RNA Products For CATSPER4
-
ViGene Biosciences ready-to-package AAV shRNAs for CATSPER4 gene
Clone Products
-
OriGene ORF clones in human for CATSPER4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CATSPER4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CATSPER4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CATSPER4
-
ViGene Biosciences adenoviral particle packaged cDNA for CATSPER4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CATSPER4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CATSPER4 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CATSPER4 Gene
Localization for CATSPER4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CATSPER4 Gene
- Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| peroxisome | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001669 | acrosomal vesicle | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005929 | cilium | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for CATSPER4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Fertilization |
1.00
1.00
|
|
Pathways by source for CATSPER4 Gene
3 Reactome pathways for CATSPER4 Gene
Interacting Proteins for CATSPER4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006814 | sodium ion transport | IEA | -- |
| GO:0006816 | calcium ion transport | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for SIGNOR curated interactions for CATSPER4 Gene
Drugs & Compounds for CATSPER4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Progesterone | Approved, Vet_approved | Pharma | Full agonist, Activator, inhibitor | Endogenous progesterone receptor agonist | 559 | |
| Mibefradil | Withdrawn | Pharma | Channel blocker, blocker | Calcium channel blocker | 3 | |
| NNC55-0396 | Pharma | Inhibition, Pore Blocker | 0 | |||
| PGE<sub>1</sub> | Pharma | Full agonist, Activator | 0 | |||
| PGE<sub>2</sub> | Pharma | Full agonist, Activator | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| PGF<sub>1alpha</sub> |
|
Full agonist, Activator |
|
Transcripts for CATSPER4 Gene
mRNA/cDNA for CATSPER4 Gene
- (3) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CATSPER4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CATSPER4
-
Santa Cruz Biotechnology (SCBT) CRISPR for CATSPER4
- GenScript: Design CRISPR guide RNA sequences for CATSPER4
miRNA Products
- Search ViGene Biosciences for CATSPER4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CATSPER4
- Browse OriGene Inhibitory RNA Products For CATSPER4
-
ViGene Biosciences ready-to-package AAV shRNAs for CATSPER4 gene
Clone Products
-
OriGene ORF clones in human for CATSPER4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CATSPER4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CATSPER4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CATSPER4 Gene
mRNA differential expression in normal tissues according to GTEx for CATSPER4 Gene
This gene is overexpressed in Testis (x47.6).
This gene is overexpressed in Platelet (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CATSPER4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CATSPER4 Gene:
CATSPER4SOURCE GeneReport for Unigene cluster for CATSPER4 Gene:
Hs.123532mRNA Expression by UniProt/SwissProt for CATSPER4 Gene:
Q7RTX7-CTSR4_HUMAN
Tissue specificity:
Testis-specific.
Primer Products
-
OriGene qPCR primer pairs for CATSPER4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CATSPER4 Gene
Orthologs for CATSPER4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CATSPER4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CATSPER4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CATSPER4 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Catsper4 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Catsper4 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CATSPER4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CATSPER4 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CATSPER4 35 |
|
OneToOne |
- Species where no ortholog for CATSPER4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CATSPER4 Gene
(1) SIMAP similar genes for CATSPER4 Gene using alignment to 2 proteins:
Variants for CATSPER4 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000049738 | -- | 26,201,708(+) | TTTTT(G/T)AGACG | intron-variant, downstream-variant-500B | |
| rs1000247849 | -- | 26,196,850(+) | CCTGT(A/G)TAAGT | intron-variant | |
| rs1000335079 | -- | 26,193,215(+) | ACAGA(C/G)CCCAG | intron-variant | |
| rs1001057111 | -- | 26,199,638(+) | ACTTA(A/G)TAGTG | intron-variant | |
| rs1001393617 | -- | 26,201,429(+) | TCGAC(A/G)AGCGG | reference, synonymous-codon, utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3577792 | CNV | loss | 25503493 |
| esv3577794 | CNV | loss | 25503493 |
| nsv1002191 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.89;
87.07% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CATSPER4 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPER4 Gene
Disorders for CATSPER4 Gene
Relevant External Links for CATSPER4
No disorders were found for CATSPER4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATSPER4 Gene
Publications for CATSPER4 Gene
- Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis. (PMID: 12932298) Lobley A. … Michalovich D. (Reprod. Biol. Endocrinol. 2003) 2 3 4 22 64
- The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 46 64
- Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. (PMID: 19343178) Soranzo N. … Deloukas P. (PLoS Genet. 2009) 3 46 64
- All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. (PMID: 17227845) Qi H. … Clapham D.E. (Proc. Natl. Acad. Sci. U.S.A. 2007) 2 3 64
- International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. (PMID: 16382101) Clapham D.E. … Garbers D.L. (Pharmacol. Rev. 2005) 2 3 64
Products for CATSPER4 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Cell Culture Products
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- Custom Antibody ServicesOriGene Antibodies for CATSPER4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CATSPER4
- Search Origene for MassSpec and Protein Over-expression Lysates for CATSPER4
- Origene Custom Protein Services for CATSPER4
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CATSPER4
- Browse OriGene Inhibitory RNA Products For CATSPER4
- OriGene qPCR primer pairs for CATSPER4
- OriGene CRISPR knockouts for CATSPER4
- OriGene ORF clones in human for CATSPER4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CATSPER4
- GenScript: Next-day shipping cDNA ORF clone for CATSPER4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CATSPER4
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- GenScript: Design CRISPR guide RNA sequences for CATSPER4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
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- Sino Biological Cell Lysates
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CATSPER4
- Novus Biologicals proteins and lysates for CATSPER4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for CATSPER4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for CATSPER4: See all 15
- antibodies-online Kits for CATSPER4: See all 3
- Search antibodies-online for proteins
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for CATSPER4
- Search GeneTex for Proteins for CATSPER4
- ViGene Biosciences adenoviral particle packaged cDNA for CATSPER4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CATSPER4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CATSPER4 gene
- Search ViGene Biosciences for CATSPER4
- Horizon Cell Lines for CATSPER4
- Cyagen custom Knockout/knockin (KOKI) mouse models for CATSPER4
- VectorBuilder custom plasmid, inducible vectors for CATSPER4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CATSPER4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CATSPER4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer