CATSPER3 Gene
protein-coding GIFtS: 45
GCID: GC05P134331
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cation channel, sperm associated 3
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Aliases for CATSPER3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Cation Channel, Sperm Associated 31 2 | | Calcium Channel Repeat Containing 12 | | CACRC1 2 | | Cation Channel Sperm-Associated Protein 32 | | Ca(V)-Like Protein2 3 | | Putative Ion Channel CatSper32 | | One-Repeat Calcium Channel-Like Protein2 3 | | CatSper33 |
Export aliases for CATSPER3 gene to outside databasesPrevious GC identifers: GC05P134334 GC05P134379 GC05P129491 |
Summaries for CATSPER3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: CTSR3_HUMAN, Q86XQ3Function: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responsesessential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards theoocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha =PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards morephysiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Spermcapacitation enhances the effect of progesterone by providing additional negative shift. Also activated by theelevation of intracellular pH Gene Wiki entry for CATSPER3 (CatSper3)
|
Genomic Views for CATSPER3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CATSPER3 gene promoter: ISGF-3 LHX3b/Lhx3b RP58 Pbx1a CUTL1 POU3F2 GATA-1 AREB6 FOXO4 LHX3a/Lhx3a Other transcription factors
Search SABiosciences Chromatin IP Primers for CATSPER3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CATSPER3 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31.1 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31.2CATSPER3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P134331: view genomic region
(about GC identifiers)
Start:
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134,303,596 bp from pter |
End:
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134,347,397 bp from pter |
Size:
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43,802 bases |
Orientation:
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plus strand |
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Proteins for CATSPER3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: CTSR3_HUMAN, Q86XQ3 (See
protein sequence)Recommended Name: Cation channel sperm-associated protein 3 Size: 398 amino acids; 46422 Da
Subunit: Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of theCatSper complex. Interacts with CATSPER1 (By similarity)
Subcellular location: Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specificallylocated in the principal piece of sperm tail
Secondary accessions: Q86XS6Explore the universe of human proteins at neXtProt for CATSPER3: NX_Q86XQ3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86XQ3 CATSPER3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_821138.1 ENSEMBL proteins: ENSP00000282611 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CATSPER3 for ontologies About GeneDecksing
CATSPER3 Antibody Products: Assay Products for CATSPER3: |
Protein
Domains / Families for CATSPER3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CATSPER3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86XQ3ProtoNet protein and cluster: Q86XQ3 UniProtKB/Swiss-Prot: CTSR3_HUMAN, Q86XQ3Similarity: Belongs to the cation channel sperm-associated (TC 1.A.1.19) family |
Function for CATSPER3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: CTSR3_HUMAN, Q86XQ3Function: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responsesessential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards theoocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha =PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards morephysiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Spermcapacitation enhances the effect of progesterone by providing additional negative shift. Also activated by theelevation of intracellular pH
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPER3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPER3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CATSPER3 (NM_178019) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CATSPER3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CATSPER3  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CATSPER3 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005227 | calcium activated cation channel activity |
IEA | -- | | GO:0005244 | voltage-gated ion channel activity |
IEA | -- | | GO:0005262 | calcium channel activity |
IEA | -- | | GO:0005515 | protein binding |
-- | -- |
CATSPER3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CATSPER3: Animal Models: Mouse knock-outs for CATSPER3: Catsper3tm1Clph Catsper3tm1Wyan 1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Catsper3):
CATSPER3 for phenotypes About GeneDecksing
|
Pathways & Interactions for CATSPER3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CATSPER3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/36 Interacting proteins for CATSPER3 (ENSP000002826114) via UniProtKB, MINT, STRING, and/or I2D (see all 36)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
CATSPER3 for ontologies About GeneDecksing
|
Drugs & Compounds for CATSPER3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for CATSPER3
1 HMDB Compound for CATSPER3 About this table Search CenterWatch for drugs/clinical trials and news about CATSPER3 / CTSR3 
|
Transcripts for CATSPER3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for CATSPER3 gene: NM_178019.2 Unigene Cluster for CATSPER3: Cation channel, sperm associated 3 Hs.631804 [show with all ESTs]Unigene Representative Sequence: BC1103842 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000282611(uc003lag.3) ENST00000511235
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPER3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPER3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CATSPER3 (NM_178019) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CATSPER3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CATSPER3  |
Additional cDNA sequence: AF432876.1 AK292427.1 AY156951.1 BC101692.1 BC110384.1 3 DOTS entries: DT.95248313 DT.120831712 DT.100009879 24/82 AceView cDNA sequences (see all 82): BN000272 NM_032151 CD365151 BI827754 BP341953 BE218596 BM804844 AY156951 NM_178019 BQ549785 BE549551 AK098495 AF432876 BP342427 BX101422 BM929591 AW003058 BE858984 BX280235 BF063510 BE619460 CA443464 BC054021 AI818340 GeneLoc Exon Structure
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Expression for CATSPER3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CATSPER3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: ACAGGTCCCT
About this image See CATSPER3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CATSPER3
SOURCE GeneReport for Unigene cluster: Hs.631804 UniProtKB/Swiss-Prot: CTSR3_HUMAN, Q86XQ3Tissue specificity: Testis-specific SABiosciences Custom PCR Arrays for CATSPER3
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CATSPER3 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CATSPER3 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CATSPER3 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CATSPER3 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CATSPER3 |
Orthologs for CATSPER3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CATSPER3 gene from 2/10 species (see all 10) About this table
ENSEMBL Gene Tree for CATSPER3 (if available) TreeFam Gene Tree for CATSPER3 (if available)  |
Paralogs for CATSPER3 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for CATSPER3 gene
- CATSPER22 CATSPER42 CATSPER12
CATSPER3 for paralogs About GeneDecksing
|
Genomic Variants for CATSPER3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 5 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for CATSPER3 (134303596 - 134347397 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for CATSPER3 2 CNVs: 51575 4479 Human Gene Mutation Database (HGMD): CATSPER3
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CATSPER3 |
|
Disorders
/ Diseases for CATSPER3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CATSPER3 for disorders About MalaCards
CATSPER3 for disorders About GeneDecksing
OMIM gene information: 609120
OMIM disorders: --
Export disorders for CATSPER3 gene to outside databases
|
Publications for CATSPER3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CATSPER3 gene, integrated from 9 sources (see all 11): (articles sorted by number of sources associating them with CATSPER3) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis. (PubMed id 12932298)1, 2, 3, 9 Lobley A.... Michalovich D. (2003)
- Cloning of a novel one-repeat calcium channel-like gene. (PubMed id 12646162)1, 2, 3 Arias J.M.... Perez-Reyes E. (2003)
- All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. (PubMed id 17227845)1, 3 Qi H....Clapham D.E. (2007)
- International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. (PubMed id 16382101)1, 3 Clapham D.E. and Garbers D.L. (2005)
- Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility. (PubMed id 17347248)2, 9 Li H.-G.... Xiong C.-L. (2007)
- Progesterone activates the principal Ca2+ channel of human sperm. (PubMed id 21412339)2 Lishko P.V.... Kirichok Y. (2011)
- The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. (PubMed id 21412338)2 Strunker T.... Kaupp U.B. (2011)
- Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1 Gudbjartsson D.F....Stefansson K. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CATSPER3 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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Genome Databases showing CATSPER3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CATSPER3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CATSPER3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for CATSPER3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CATSPER3 gene: Search GeneIP for patents involving CATSPER3
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for CATSPER3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for CATSPER3 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CATSPER3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CATSPER3 | | OriGene Protein Over-expression Lysate for CATSPER3 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for CATSPER3 | | OriGene 3'-UTR Clone for CATSPER3 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPER3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPER3 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for CATSPER3 | | OriGene Custom Protein Services for CATSPER3 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CATSPER3 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CATSPER3 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CATSPER3 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CATSPER3 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CATSPER3 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CATSPER3 |
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 | | CATSPER3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CATSPER3 |
|  |  |  | | | Search ThermoFisher Antibodies for CATSPER3 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CATSPER3 |
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