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Aliases for CATSPER3 Gene

Aliases for CATSPER3 Gene

  • Cation Channel Sperm Associated 3 2 3 5
  • One-Repeat Calcium Channel-Like Protein 3 4
  • Ca(V)-Like Protein 3 4
  • Cation Channel Sperm-Associated Protein 3 3
  • Calcium Channel Repeat Containing 1 3
  • Cation Channel, Sperm Associated 3 2
  • Putative Ion Channel CatSper3 3
  • CatSper3 4
  • CACRC 3

External Ids for CATSPER3 Gene

Previous GeneCards Identifiers for CATSPER3 Gene

  • GC05P134334
  • GC05P134379
  • GC05P134331
  • GC05P129491

Summaries for CATSPER3 Gene

GeneCards Summary for CATSPER3 Gene

CATSPER3 (Cation Channel Sperm Associated 3) is a Protein Coding gene. Among its related pathways are Reproduction. GO annotations related to this gene include ion channel activity and calcium activated cation channel activity. An important paralog of this gene is CATSPER4.

UniProtKB/Swiss-Prot for CATSPER3 Gene

  • Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.

Gene Wiki entry for CATSPER3 Gene

Additional gene information for CATSPER3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CATSPER3 Gene

Genomics for CATSPER3 Gene

Regulatory Elements for CATSPER3 Gene

Enhancers for CATSPER3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H134546 2 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -415.8 -415847 10 HDGF PKNOX1 ARNT SIN3A YBX1 GLI4 BRCA1 ZBTB7B TCF12 GLIS2 DDX46 SEC24A C5orf66 CAMLG PPP2CA JADE2 CATSPER3 UBE2B TXNDC15 CDKL3
GH05H134508 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -457.1 -457083 4 HDGF PKNOX1 FOXA2 ZFP64 ARID4B DMAP1 ZBTB7B YY1 ZNF766 ZNF416 DDX46 C5orf24 RPS10P11 CDKN2AIPNL ENSG00000248559 CATSPER3 SKP1 LINC01843 CAMLG RN7SL541P
GH05H135137 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +172.1 172136 5 PKNOX1 FOXA2 ARNT BRCA1 GLIS2 ATF7 FOS DEK SP5 SMARCB1 SMAD5 PITX1 DDX46 CATSPER3 LOC105379188 C5orf66-AS2
GH05H134410 1.4 FANTOM5 ENCODE 10.7 -553.1 -553116 8 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 DDX46 RNU6-456P JADE2 CATSPER3 CDKL3 C5orf66 SKP1 CDKN2AIPNL RPS10P11
GH05H135155 1.3 ENCODE dbSUPER 10.6 +188.8 188819 2 HDGF FOXA2 MLX ARNT ARID4B DMAP1 SP5 MXD4 NFYC MIER2 CATSPER3 LOC105379188 C5orf66-AS2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CATSPER3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CATSPER3 Gene

Chromosome:
5
Start:
134,967,906 bp from pter
End:
135,011,707 bp from pter
Size:
43,802 bases
Orientation:
Plus strand

Genomic View for CATSPER3 Gene

Genes around CATSPER3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CATSPER3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CATSPER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATSPER3 Gene

Proteins for CATSPER3 Gene

  • Protein details for CATSPER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XQ3-CTSR3_HUMAN
    Recommended name:
    Cation channel sperm-associated protein 3
    Protein Accession:
    Q86XQ3
    Secondary Accessions:
    • Q86XS6

    Protein attributes for CATSPER3 Gene

    Size:
    398 amino acids
    Molecular mass:
    46422 Da
    Quaternary structure:
    • Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the CatSper complex. Interacts with CATSPER1 (By similarity).

neXtProt entry for CATSPER3 Gene

Post-translational modifications for CATSPER3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CATSPER3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CATSPER3 Gene

Domains & Families for CATSPER3 Gene

Gene Families for CATSPER3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for CATSPER3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CATSPER3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XQ3

UniProtKB/Swiss-Prot:

CTSR3_HUMAN :
  • Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.
Family:
  • Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.
genes like me logo Genes that share domains with CATSPER3: view

Function for CATSPER3 Gene

Molecular function for CATSPER3 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
The CatSper calcium channel is indirectly activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2 (PubMed:21412338, PubMed:21412339, PubMed:26989199). The CatSper calcium channel is directly inhibited by endocannabinoid 2-arachidonoylglycerol (2AG) (PubMed:26989199). Indirect activation by progesterone takes place via the following mechanism: progesterone binds and activates the acylglycerol lipase ABHD2, which in turn mediates hydrolysis of 2AG inhibitor, relieving inhibition of the CatSper channel (PubMed:26989199). The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers (PubMed:21412338, PubMed:21412339). Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH (PubMed:21412338, PubMed:21412339).
UniProtKB/Swiss-Prot Function:
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.

Phenotypes From GWAS Catalog for CATSPER3 Gene

Gene Ontology (GO) - Molecular Function for CATSPER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IEA --
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005245 voltage-gated calcium channel activity IEA --
GO:0005261 cation channel activity IBA --
GO:0005262 calcium channel activity IEA --
genes like me logo Genes that share ontologies with CATSPER3: view
genes like me logo Genes that share phenotypes with CATSPER3: view

Animal Models for CATSPER3 Gene

MGI Knock Outs for CATSPER3:

Animal Model Products

  • Taconic Biosciences Mouse Models for CATSPER3

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CATSPER3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CATSPER3 Gene

Localization for CATSPER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CATSPER3 Gene

Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CATSPER3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for CATSPER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane IBA,TAS --
GO:0005929 cilium IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CATSPER3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CATSPER3 Gene

Pathways & Interactions for CATSPER3 Gene

SuperPathways for CATSPER3 Gene

SuperPathway Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with CATSPER3: view

Pathways by source for CATSPER3 Gene

3 Reactome pathways for CATSPER3 Gene

Gene Ontology (GO) - Biological Process for CATSPER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0006816 calcium ion transport IBA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with CATSPER3: view

No data available for SIGNOR curated interactions for CATSPER3 Gene

Drugs & Compounds for CATSPER3 Gene

(7) Drugs for CATSPER3 Gene - From: DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved, Vet_approved Pharma Full agonist, Activator, inhibitor Endogenous progesterone receptor agonist 578
Mibefradil Withdrawn Pharma Channel blocker, blocker Calcium channel blocker 3
NNC55-0396 Pharma Inhibition, Pore Blocker 0
PGE<sub>1</sub> Pharma Full agonist, Activator 0
PGE<sub>2</sub> Pharma Full agonist, Activator 0

(1) Additional Compounds for CATSPER3 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PGF<sub>1alpha</sub>
Full agonist, Activator
genes like me logo Genes that share compounds with CATSPER3: view

Transcripts for CATSPER3 Gene

mRNA/cDNA for CATSPER3 Gene

Unigene Clusters for CATSPER3 Gene

Cation channel, sperm associated 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CATSPER3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CATSPER3 Gene

No ASD Table

Relevant External Links for CATSPER3 Gene

GeneLoc Exon Structure for
CATSPER3
ECgene alternative splicing isoforms for
CATSPER3

Expression for CATSPER3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CATSPER3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CATSPER3 Gene

This gene is overexpressed in Testis (x21.6).

Protein differential expression in normal tissues from HIPED for CATSPER3 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CATSPER3 Gene



Protein tissue co-expression partners for CATSPER3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CATSPER3 Gene:

CATSPER3

SOURCE GeneReport for Unigene cluster for CATSPER3 Gene:

Hs.631804

mRNA Expression by UniProt/SwissProt for CATSPER3 Gene:

Q86XQ3-CTSR3_HUMAN
Tissue specificity: Testis-specific.

Evidence on tissue expression from TISSUES for CATSPER3 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with CATSPER3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CATSPER3 Gene

Orthologs for CATSPER3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CATSPER3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CATSPER3 33 34
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia CATSPER3 33 34
  • 82.91 (n)
cow
(Bos Taurus)
Mammalia CATSPER3 33 34
  • 80.74 (n)
mouse
(Mus musculus)
Mammalia Catsper3 33 16 34
  • 74.08 (n)
rat
(Rattus norvegicus)
Mammalia Catsper3 33
  • 73.33 (n)
oppossum
(Monodelphis domestica)
Mammalia CATSPER3 34
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CATSPER3 34
  • 47 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToOne
Species where no ortholog for CATSPER3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CATSPER3 Gene

ENSEMBL:
Gene Tree for CATSPER3 (if available)
TreeFam:
Gene Tree for CATSPER3 (if available)

Paralogs for CATSPER3 Gene

Paralogs for CATSPER3 Gene

genes like me logo Genes that share paralogs with CATSPER3: view

Variants for CATSPER3 Gene

Sequence variations from dbSNP and Humsavar for CATSPER3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000004533 -- 134,997,016(+) TTGCT(A/G)AAAAC intron-variant
rs1000114835 -- 135,007,710(+) CAGAC(A/G)CTGGT intron-variant
rs1000217408 -- 135,011,678(+) CCCTA(C/T)TAAAC utr-variant-3-prime
rs1000300586 -- 134,987,441(+) AACTC(A/T)ACCAA intron-variant
rs1000327603 -- 134,970,562(+) TGACA(C/T)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CATSPER3 Gene

Variant ID Type Subtype PubMed ID
nsv5013 CNV insertion 18451855
nsv519879 CNV loss 19592680
nsv830494 CNV gain+loss 17160897

Variation tolerance for CATSPER3 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CATSPER3 Gene

Human Gene Mutation Database (HGMD)
CATSPER3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CATSPER3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPER3 Gene

Disorders for CATSPER3 Gene

Relevant External Links for CATSPER3

Genetic Association Database (GAD)
CATSPER3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CATSPER3

No disorders were found for CATSPER3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATSPER3 Gene

Publications for CATSPER3 Gene

  1. Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis. (PMID: 12932298) Lobley A … Michalovich D (Reproductive biology and endocrinology : RB&E 2003) 2 3 4 22 60
  2. Cloning of a novel one-repeat calcium channel-like gene. (PMID: 12646162) Arias JM … Perez-Reyes E (Biochemical and biophysical research communications 2003) 2 3 4 60
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 45 60
  4. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. (PMID: 17227845) Qi H … Clapham DE (Proceedings of the National Academy of Sciences of the United States of America 2007) 2 3 60
  5. Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility. (PMID: 17347248) Li HG … Xiong CL (Molecular human reproduction 2007) 4 22 60

Products for CATSPER3 Gene

Sources for CATSPER3 Gene

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