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Aliases for CATSPER3 Gene

Aliases for CATSPER3 Gene

  • Cation Channel Sperm Associated 3 2 3
  • Cation Channel, Sperm Associated 3 2 3 5
  • One-Repeat Calcium Channel-Like Protein 3 4
  • Ca(V)-Like Protein 3 4
  • Calcium Channel Repeat Containing 1 3
  • Putative Ion Channel CatSper3 3
  • CatSper3 4
  • CACRC 3

External Ids for CATSPER3 Gene

Previous GeneCards Identifiers for CATSPER3 Gene

  • GC05P134334
  • GC05P134379
  • GC05P134331
  • GC05P129491

Summaries for CATSPER3 Gene

GeneCards Summary for CATSPER3 Gene

CATSPER3 (Cation Channel Sperm Associated 3) is a Protein Coding gene. Among its related pathways are Reproduction. GO annotations related to this gene include ion channel activity and calcium activated cation channel activity. An important paralog of this gene is CATSPER2.

UniProtKB/Swiss-Prot for CATSPER3 Gene

  • Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.

Gene Wiki entry for CATSPER3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CATSPER3 Gene

Genomics for CATSPER3 Gene

Regulatory Elements for CATSPER3 Gene

Enhancers for CATSPER3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CATSPER3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CATSPER3 Gene

Chromosome:
5
Start:
134,967,906 bp from pter
End:
135,011,707 bp from pter
Size:
43,802 bases
Orientation:
Plus strand

Genomic View for CATSPER3 Gene

Genes around CATSPER3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CATSPER3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CATSPER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATSPER3 Gene

Proteins for CATSPER3 Gene

  • Protein details for CATSPER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XQ3-CTSR3_HUMAN
    Recommended name:
    Cation channel sperm-associated protein 3
    Protein Accession:
    Q86XQ3
    Secondary Accessions:
    • Q86XS6

    Protein attributes for CATSPER3 Gene

    Size:
    398 amino acids
    Molecular mass:
    46422 Da
    Quaternary structure:
    • Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the CatSper complex. Interacts with CATSPER1 (By similarity).

neXtProt entry for CATSPER3 Gene

Proteomics data for CATSPER3 Gene at MOPED

Post-translational modifications for CATSPER3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CATSPER3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CATSPER3 Gene

Domains & Families for CATSPER3 Gene

Gene Families for CATSPER3 Gene

Protein Domains for CATSPER3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CATSPER3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XQ3

UniProtKB/Swiss-Prot:

CTSR3_HUMAN :
  • Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.
Family:
  • Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.
genes like me logo Genes that share domains with CATSPER3: view

Function for CATSPER3 Gene

Molecular function for CATSPER3 Gene

UniProtKB/Swiss-Prot Function:
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.

Gene Ontology (GO) - Molecular Function for CATSPER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IEA --
genes like me logo Genes that share ontologies with CATSPER3: view
genes like me logo Genes that share phenotypes with CATSPER3: view

Animal Models for CATSPER3 Gene

MGI Knock Outs for CATSPER3:

Animal Model Products

  • Taconic Biosciences Mouse Models for CATSPER3

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CATSPER3 Gene

Localization for CATSPER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CATSPER3 Gene

Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CATSPER3 Gene COMPARTMENTS Subcellular localization image for CATSPER3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for CATSPER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036128 CatSper complex IEA,ISS --
genes like me logo Genes that share ontologies with CATSPER3: view

Pathways & Interactions for CATSPER3 Gene

SuperPathways for CATSPER3 Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with CATSPER3: view

Pathways by source for CATSPER3 Gene

3 Reactome pathways for CATSPER3 Gene

Interacting Proteins for CATSPER3 Gene

Gene Ontology (GO) - Biological Process for CATSPER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007338 single fertilization TAS --
GO:0030317 sperm motility IEA --
GO:0034220 ion transmembrane transport IBA --
GO:0048240 sperm capacitation IEA --
genes like me logo Genes that share ontologies with CATSPER3: view

No data available for SIGNOR curated interactions for CATSPER3 Gene

Drugs & Compounds for CATSPER3 Gene

(7) Drugs for CATSPER3 Gene - From: DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved Pharma Full agonist, Activator, inhibitor Endogenous progesterone receptor agonist 511
Mibefradil Withdrawn Pharma Channel blocker, blocker 3
NNC55-0396 Pharma Inhibition, Pore Blocker 0
PGE<sub>1</sub> Pharma Full agonist, Activator 0
PGE<sub>2</sub> Pharma Full agonist, Activator 0

(1) Additional Compounds for CATSPER3 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PGF<sub>1alpha</sub>
Full agonist, Activator
genes like me logo Genes that share compounds with CATSPER3: view

Transcripts for CATSPER3 Gene

mRNA/cDNA for CATSPER3 Gene

Unigene Clusters for CATSPER3 Gene

Cation channel, sperm associated 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CATSPER3 Gene

No ASD Table

Relevant External Links for CATSPER3 Gene

GeneLoc Exon Structure for
CATSPER3
ECgene alternative splicing isoforms for
CATSPER3

Expression for CATSPER3 Gene

mRNA expression in normal human tissues for CATSPER3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CATSPER3 Gene

This gene is overexpressed in Testis (x21.6).

Protein differential expression in normal tissues from HIPED for CATSPER3 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CATSPER3 Gene



SOURCE GeneReport for Unigene cluster for CATSPER3 Gene Hs.631804

mRNA Expression by UniProt/SwissProt for CATSPER3 Gene

Q86XQ3-CTSR3_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with CATSPER3: view

Protein tissue co-expression partners for CATSPER3 Gene

Primer Products

In Situ Assay Products

Orthologs for CATSPER3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CATSPER3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CATSPER3 35
  • 80.74 (n)
  • 73.12 (a)
CATSPER3 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CATSPER3 35
  • 82.91 (n)
  • 75.88 (a)
CATSPER3 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Catsper3 35
  • 74.08 (n)
  • 65.98 (a)
Catsper3 16
Catsper3 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CATSPER3 35
  • 99.58 (n)
  • 99.25 (a)
CATSPER3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Catsper3 35
  • 73.33 (n)
  • 66.1 (a)
oppossum
(Monodelphis domestica)
Mammalia CATSPER3 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CATSPER3 36
  • 47 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToOne
Species with no ortholog for CATSPER3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CATSPER3 Gene

ENSEMBL:
Gene Tree for CATSPER3 (if available)
TreeFam:
Gene Tree for CATSPER3 (if available)

Paralogs for CATSPER3 Gene

Paralogs for CATSPER3 Gene

genes like me logo Genes that share paralogs with CATSPER3: view

Variants for CATSPER3 Gene

Sequence variations from dbSNP and Humsavar for CATSPER3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs3896260 - 135,008,076(+) GACAA(G/T)GGTGA reference, missense
rs804883 -- 134,994,975(+) cctcc(C/T)ttctt intron-variant
rs877811 -- 135,010,795(-) TGGAG(A/C)CTTCA intron-variant
rs877812 -- 135,010,614(-) CATCA(C/T)CCCCT intron-variant
rs929324 -- 135,010,713(+) GTGGA(C/T)GGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CATSPER3 Gene

Variant ID Type Subtype PubMed ID
nsv830494 CNV Gain+Loss 17160897
nsv5013 CNV Insertion 18451855
nsv882924 CNV Loss 21882294
nsv519879 CNV Loss 19592680

Variation tolerance for CATSPER3 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CATSPER3 Gene

HapMap Linkage Disequilibrium report
CATSPER3
Human Gene Mutation Database (HGMD)
CATSPER3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPER3 Gene

Disorders for CATSPER3 Gene

Relevant External Links for CATSPER3

Genetic Association Database (GAD)
CATSPER3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CATSPER3

No disorders were found for CATSPER3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATSPER3 Gene

Publications for CATSPER3 Gene

  1. Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis. (PMID: 12932298) Lobley A. … Michalovich D. (Reprod. Biol. Endocrinol. 2003) 2 3 4 23 67
  2. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. (PMID: 17227845) Qi H. … Clapham D.E. (Proc. Natl. Acad. Sci. U.S.A. 2007) 2 3
  3. International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. (PMID: 16382101) Clapham D.E. … Garbers D.L. (Pharmacol. Rev. 2005) 2 3
  4. Cloning of a novel one-repeat calcium channel-like gene. (PMID: 12646162) Arias J.M. … Perez-Reyes E. (Biochem. Biophys. Res. Commun. 2003) 2 3
  5. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3

Products for CATSPER3 Gene

Sources for CATSPER3 Gene

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