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Aliases for CATSPER3 Gene

Aliases for CATSPER3 Gene

  • Cation Channel, Sperm Associated 3 2 3
  • One-Repeat Calcium Channel-Like Protein 3 4
  • Ca(V)-Like Protein 3 4
  • CACRC 3 6
  • Cation Channel Sperm-Associated Protein 3 3
  • Calcium Channel Repeat Containing 1 3
  • Putative Ion Channel CatSper3 3
  • CatSper3 4

External Ids for CATSPER3 Gene

Summaries for CATSPER3 Gene

GeneCards Summary for CATSPER3 Gene

CATSPER3 (Cation Channel, Sperm Associated 3) is a Protein Coding gene. Among its related pathways are Reproduction and Reproduction. GO annotations related to this gene include calcium channel activity and calcium activated cation channel activity. An important paralog of this gene is CATSPER4.

UniProtKB/Swiss-Prot for CATSPER3 Gene

  • Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.

Gene Wiki entry for CATSPER3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CATSPER3 Gene

Genomics for CATSPER3 Gene

Genomic Location for CATSPER3 Gene

Start:
134,967,906 bp from pter
End:
135,011,707 bp from pter
Size:
43,802 bases
Orientation:
Plus strand

Genomic View for CATSPER3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CATSPER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATSPER3 Gene

Regulatory Elements for CATSPER3 Gene

Proteins for CATSPER3 Gene

  • Protein details for CATSPER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XQ3-CTSR3_HUMAN
    Recommended name:
    Cation channel sperm-associated protein 3
    Protein Accession:
    Q86XQ3
    Secondary Accessions:
    • Q86XS6

    Protein attributes for CATSPER3 Gene

    Size:
    398 amino acids
    Molecular mass:
    46422 Da
    Quaternary structure:
    • Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the CatSper complex. Interacts with CATSPER1 (By similarity).

neXtProt entry for CATSPER3 Gene

Proteomics data for CATSPER3 Gene at MOPED

Post-translational modifications for CATSPER3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CATSPER3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CATSPER3 Gene

Domains for CATSPER3 Gene

Gene Families for CATSPER3 Gene

HGNC:
  • CATSPER :Voltage-gated ion channels / Cation channels, sperm associated
IUPHAR :

Protein Domains for CATSPER3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CTSR3_HUMAN
Family:
  • Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.:
    • Q86XQ3
genes like me logo Genes that share domains with CATSPER3: view

Function for CATSPER3 Gene

Molecular function for CATSPER3 Gene

UniProtKB/Swiss-Prot Function: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.

Gene Ontology (GO) - Molecular Function for CATSPER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005227 calcium activated cation channel activity IEA --
GO:0005245 voltage-gated calcium channel activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CATSPER3: view

Phenotypes for CATSPER3 Gene

genes like me logo Genes that share phenotypes with CATSPER3: view

Animal Models for CATSPER3 Gene

MGI Knock Outs for CATSPER3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CATSPER3 Gene

Localization for CATSPER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CATSPER3 Gene

Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CATSPER3 Gene COMPARTMENTS Subcellular localization image for CATSPER3 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for CATSPER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with CATSPER3: view

Pathways for CATSPER3 Gene

SuperPathways for CATSPER3 Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with CATSPER3: view

Pathways by source for CATSPER3 Gene

3 Reactome pathways for CATSPER3 Gene

Interacting Proteins for CATSPER3 Gene

Gene Ontology (GO) - Biological Process for CATSPER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006814 sodium ion transport IEA --
GO:0007275 multicellular organismal development IEA --
GO:0007338 single fertilization TAS --
GO:0030317 sperm motility IBA --
genes like me logo Genes that share ontologies with CATSPER3: view

Compounds for CATSPER3 Gene

(1) HMDB Compounds for CATSPER3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(6) IUPHAR Ligand for CATSPER3 Gene

Ligand Type Action Affinity Pubmed IDs
mibefradil Pore Blocker Antagonist 6.8
PGF1alpha Activator Full agonist 6.3
PGE1 Activator Full agonist 6.3
NNC55-0396 Pore Blocker Inhibition 5.7
progesterone Pore Blocker Inhibition 5.3
PGE2 Agonist Full agonist 4.5
genes like me logo Genes that share compounds with CATSPER3: view

Transcripts for CATSPER3 Gene

mRNA/cDNA for CATSPER3 Gene

Unigene Clusters for CATSPER3 Gene

Cation channel, sperm associated 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CATSPER3 Gene

No ASD Table

Relevant External Links for CATSPER3 Gene

GeneLoc Exon Structure for
CATSPER3
ECgene alternative splicing isoforms for
CATSPER3

Expression for CATSPER3 Gene

mRNA expression in normal human tissues for CATSPER3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CATSPER3 Gene

This gene is overexpressed in Testis (21.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CATSPER3 Gene

SOURCE GeneReport for Unigene cluster for CATSPER3 Gene Hs.631804

mRNA Expression by UniProt/SwissProt for CATSPER3 Gene

Q86XQ3-CTSR3_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expressions with CATSPER3: view

Orthologs for CATSPER3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CATSPER3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CATSPER3 36
  • 99.58 (n)
  • 99.25 (a)
CATSPER3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CATSPER3 36
  • 80.74 (n)
  • 73.12 (a)
CATSPER3 37
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CATSPER3 36
  • 82.91 (n)
  • 75.88 (a)
CATSPER3 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Catsper3 36
  • 74.08 (n)
  • 65.98 (a)
Catsper3 16
Catsper3 37
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CATSPER3 37
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Catsper3 36
  • 73.33 (n)
  • 66.1 (a)
lizard
(Anolis carolinensis)
Reptilia CATSPER3 37
  • 47 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
OneToOne
Species with no ortholog for CATSPER3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CATSPER3 Gene

ENSEMBL:
Gene Tree for CATSPER3 (if available)
TreeFam:
Gene Tree for CATSPER3 (if available)

Paralogs for CATSPER3 Gene

Paralogs for CATSPER3 Gene

genes like me logo Genes that share paralogs with CATSPER3: view

Variants for CATSPER3 Gene

Sequence variations from dbSNP and Humsavar for CATSPER3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs177251 -- 135,007,779(+) AATTC(A/G)TTAGT intron-variant
rs177252 -- 135,008,109(+) GCTGC(A/G)GCTTT reference, synonymous-codon
rs186156 -- 135,004,797(+) GCCCT(A/G)CCCAA intron-variant
rs188487 -- 134,980,241(+) cctcc(C/T)gaagc intron-variant
rs213506 -- 135,002,533(+) agttc(C/T)cctgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CATSPER3 Gene

Variant ID Type Subtype PubMed ID
nsv830494 CNV Gain+Loss 17160897
nsv5013 CNV Insertion 18451855
nsv882924 CNV Loss 21882294
nsv519879 CNV Loss 19592680

Relevant External Links for CATSPER3 Gene

HapMap Linkage Disequilibrium report
CATSPER3
Human Gene Mutation Database (HGMD)
CATSPER3

Disorders for CATSPER3 Gene

Relevant External Links for CATSPER3

Genetic Association Database (GAD)
CATSPER3
genes like me logo Genes that share disorders with CATSPER3: view

No data available for UniProtKB/Swiss-Prot for CATSPER3 Gene

Publications for CATSPER3 Gene

  1. Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis. (PMID: 12932298) Lobley A. … Michalovich D. (Reprod. Biol. Endocrinol. 2003) 2 3 4 23
  2. Cloning of a novel one-repeat calcium channel-like gene. (PMID: 12646162) Arias J.M. … Perez-Reyes E. (Biochem. Biophys. Res. Commun. 2003) 2 3 4
  3. International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. (PMID: 16382101) Clapham D.E. … Garbers D.L. (Pharmacol. Rev. 2005) 2 3
  4. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. (PMID: 17227845) Qi H. … Clapham D.E. (Proc. Natl. Acad. Sci. U.S.A. 2007) 2 3
  5. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 49

Products for CATSPER3 Gene

Sources for CATSPER3 Gene

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