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CATSPER3 Gene

protein-coding   GIFtS: 51
GCID: GC05P134331

Cation Channel, Sperm Associated 3

  Search for CATSPER3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cation Channel, Sperm Associated 31 2     Calcium Channel Repeat Containing 12
Ca(V)-Like Protein2 3     Cation Channel Sperm-Associated Protein 32
One-Repeat Calcium Channel-Like Protein2 3     Putative Ion Channel CatSper32
CACRC2 5     CatSper33

External Ids:    HGNC: 208191   Entrez Gene: 3477322   Ensembl: ENSG000001527057   OMIM: 6091205   UniProtKB: Q86XQ33   
ORGUL members:         

Export aliases for CATSPER3 gene to outside databases

Previous GC identifers: GC05P134334 GC05P134379 GC05P129491


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CATSPER3 Gene:
CATSPER3 (cation channel, sperm associated 3) is a protein-coding gene. GO annotations related to this gene include calcium activated cation channel activity and calcium channel activity. An important paralog of this gene is CATSPER4.

UniProtKB/Swiss-Prot: CTSR3_HUMAN, Q86XQ3
Function: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses
essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards
the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone >
PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage
dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors
and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative
shift. Also activated by the elevation of intracellular pH

Gene Wiki entry for CATSPER3 (CatSper3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the CATSPER3 gene promoter:
         ISGF-3   LHX3b/Lhx3b   RP58   Pbx1a   CUTL1   POU3F2   GATA-1   AREB6   FOXO4   LHX3a/Lhx3a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CATSPER3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CATSPER3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.2

CATSPER3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CATSPER3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P134331:  view genomic region     (about GC identifiers)

Start:
134,303,596 bp from pter      End:
134,347,397 bp from pter
Size:
43,802 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CTSR3_HUMAN, Q86XQ3 (See protein sequence)
Recommended Name: Cation channel sperm-associated protein 3  
Size: 398 amino acids; 46422 Da
Subunit: Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of
the CatSper complex. Interacts with CATSPER1 (By similarity)
Secondary accessions: Q86XS6

Explore the universe of human proteins at neXtProt for CATSPER3: NX_Q86XQ3

Explore proteomics data for CATSPER3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CATSPER3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_821138.1  
    ENSEMBL proteins: 
     ENSP00000282611  
    Reactome Protein details: Q86XQ3

    CATSPER3 Human Recombinant Protein Products:

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    Novus Biologicals CATSPER3 Protein
    Novus Biologicals CATSPER3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CATSPER3

     
    Search eBioscience for Proteins for CATSPER3 

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    Search eBioscience for ELISAs for CATSPER3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CATSPER: Voltage-gated ion channels / Cation channels, sperm associated

    IUPHAR Guide to PHARMACOLOGY protein family classification: CatSper3
    CatSper and Two-Pore channels

    2 InterPro protein domains:
     IPR028739 Cat_Sper_3
     IPR005821 Ion_trans_dom

    Graphical View of Domain Structure for InterPro Entry Q86XQ3

    ProtoNet protein and cluster: Q86XQ3

    UniProtKB/Swiss-Prot: CTSR3_HUMAN, Q86XQ3
    Similarity: Belongs to the cation channel sperm-associated (TC 1.A.1.19) family


    Find genes that share domains with CATSPER3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTSR3_HUMAN, Q86XQ3
    Function: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses
    essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards
    the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone >
    PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage
    dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors
    and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative
    shift. Also activated by the elevation of intracellular pH

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005227calcium activated cation channel activity IEA--
    GO:0005244voltage-gated ion channel activity IEA--
    GO:0005262calcium channel activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CATSPER3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CATSPER3:
     Decreased viability of wild-ty 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Catsper3):
     reproductive system 

    Find genes that share phenotypes with CATSPER3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CATSPER3: Catsper3tm1Clph Catsper3tm1Wyan

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CATSPER3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CATSPER3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CATSPER3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CATSPER3

    miRNA
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    GenScript: all cDNA clones in your preferred vector: CATSPER3 (NM_178019)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CTSR3_HUMAN, Q86XQ3: Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically
    located in the principal piece of sperm tail
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane TAS--
    GO:0005929cilium IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with CATSPER3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CATSPER3 About    
    See pathways by source

    SuperPathContained pathways About
    1Reproduction
    Reproduction1.00
    Sperm Motility And Taxes0.00
    Fertilization1.00


    Find genes that share SuperPaths with CATSPER3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for CATSPER3
        Sperm Motility And Taxes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CATSPER3
    Interactions:

        Search GeneGlobe Interaction Network for CATSPER3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CATSPER3 (ENSP000002826114) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKAP6ENSP000002809794STRING: ENSP00000280979
    CACNA1BENSP000002775494STRING: ENSP00000277549
    CACNA1CENSP000002663764STRING: ENSP00000266376
    CACNA1DENSP000002881394STRING: ENSP00000288139
    CACNA1EENSP000003565454STRING: ENSP00000356545
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001539cilium or flagellum-dependent cell motility IEA--
    GO:0006811ion transport ----
    GO:0006814sodium ion transport IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--

    Find genes that share ontologies with CATSPER3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CATSPER3 (CTSR3)

    1 HMDB Compound for CATSPER3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    6 IUPHAR Ligands for CATSPER3 (CatSper3)    About this table
    LigandTypeActionAffinityPubmed IDs
    progesterone
    ActivatorFull agonist8.1121412339 21412338
    PGF1alpha
    ActivatorFull agonist6.321412339
    PGE1
    ActivatorFull agonist6.321412339
    PGE2
    ActivatorFull agonist6.321412339
    NNC55-0396
    Pore BlockerInhibition5.721412339 21412338
    mibefradil
    Pore BlockerInhibition4.4 - 4.5221412338



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CATSPER3 gene: 
    NM_178019.2  

    Unigene Cluster for CATSPER3:

    Cation channel, sperm associated 3
    Hs.631804  [show with all ESTs]
    Unigene Representative Sequence: BC110384
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282611(uc003lag.3) ENST00000511235
    miRNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CATSPER3
      QuantiTect SYBR Green Assays in human, mouse, rat CATSPER3
      QuantiFast Probe-based Assays in human, mouse, rat CATSPER3

    Additional mRNA sequence: 

    AF432876.1 AK292427.1 AY156951.1 BC101692.1 BC110384.1 

    3 DOTS entries:

    DT.95248313  DT.120831712  DT.100009879 

    Selected AceView cDNA sequences (see all 82):

    AY156951 AF432876 BE218596 BP342427 BN000272 BM804844 BP341953 AK098495 
    NM_178019 BI827754 BX101422 NM_032151 BE549551 BM929591 BQ549785 CD365151 
    BU615533 BF063510 AI219834 CK820306 AW008956 AL136721 CA443464 BG055904 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CATSPER3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGGTCCCT
    CATSPER3 Expression
    About this image


    CATSPER3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Spermatid Seminiferous Tubules
     
     Gonad
             Spermatid Seminiferous Tubules
    CATSPER3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CATSPER3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631804

    UniProtKB/Swiss-Prot: CTSR3_HUMAN, Q86XQ3
    Tissue specificity: Testis-specific

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CATSPER3 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Catsper31 , 5 cation channel, sperm associated 31, 5 74.08(n)1
    65.98(a)1
      13 (30.06 cM)5
    768561  NM_001252487.11  NP_001239416.11 
     557845685 
    lizard
    (Anolis carolinensis)
    Reptilia CATSPER36
    cation channel, sperm associated 3
    47(a)
    1 ↔ 1
    GL343223.1(403265-433458)


    ENSEMBL Gene Tree for CATSPER3 (if available)
    TreeFam Gene Tree for CATSPER3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CATSPER3 gene
    CATSPER42  

    Find genes that share paralogs with CATSPER3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CATSPER3 (see all 882)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs347364731,2
    C--129530488(+) AAAAAT/AAATAA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1872654121,2
    C--134301627(+) TCATAC/TGGCAC 1 -- us2k10--------
    rs1892380671,2
    --134301628(+) CATACA/GGCACA 1 -- us2k10--------
    rs1411923391,2
    --134301639(+) CACTTA/GCTGAG 1 -- us2k10--------
    rs1453831901,2
    --134301670(+) GGATTA/GAGCAC 1 -- us2k10--------
    rs753432981,2
    C,F--134301718(+) TGATGC/AGGGCT 1 -- us2k11Minor allele frequency- A:0.05EA 120
    rs1807160791,2
    --134302255(+) AAAATA/CCCTAT 1 -- us2k10--------
    rs798193381,2
    C,F--134302259(+) TCCCTA/CTTACT 1 -- us2k11Minor allele frequency- C:0.05EA 120
    rs782625701,2
    F--134302283(+) CATCTC/GTGCCA 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1863608201,2
    --134302329(+) TATATA/GTGCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CATSPER3 (134303596 - 134347397 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CATSPER3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5013CNV Insertion18451855
    nsv882924CNV Loss21882294
    nsv519879CNV Loss19592680
    nsv830494CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): CATSPER3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CATSPER3
    DNA2.0 Custom Variant and Variant Library Synthesis for CATSPER3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609120    OMIM disorders: --


    Find genes that share disorders with CATSPER3           About GenesLikeMe

    Genetic Association Database (GAD): CATSPER3

    Export disorders for CATSPER3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CATSPER3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with CATSPER3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis. (PubMed id 12932298)1, 2, 3, 9 Lobley A.... Michalovich D. (Reprod. Biol. Endocrinol. 2003)
    2. Cloning of a novel one-repeat calcium channel-like gene. (PubMed id 12646162)1, 2, 3 Arias J.M.... Perez-Reyes E. (Biochem. Biophys. Res. Commun. 2003)
    3. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    4. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. (PubMed id 17227845)1, 3 Qi H....Clapham D.E. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    5. International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. (PubMed id 16382101)1, 3 Clapham D.E. and Garbers D.L. (Pharmacol. Rev. 2005)
    6. Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility. (PubMed id 17347248)2, 9 Li H.-G.... Xiong C.-L. (Mol. Hum. Reprod. 2007)
    7. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (Int J Eat Disord 2013)
    8. Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. (PubMed id 23263487)1 Jia W.H....Zheng W. (Nat. Genet. 2013)
    9. Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. (PubMed id 23666240)1 Ruark E....Turnbull C. (Nat. Genet. 2013)
    10. Progesterone activates the principal Ca2+ channel of human sperm. (PubMed id 21412339)2 Lishko P.V.... Kirichok Y. (Nature 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 347732 HGNC: 20819 AceView: DCOHMandCATSPER3 Ensembl:ENSG00000152705 euGenes: HUgn347732
    ECgene: CATSPER3 H-InvDB: CATSPER3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CATSPER3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CATSPER3 gene:
    Search GeneIP for patents involving CATSPER3

    GeneCards and IP:
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