Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CATSPER2 Gene

protein-coding   GIFtS: 52
GCID: GC15M043920

cation channel, sperm associated 2

 Explore 7 diseases affiliated with
CATSPER2 via our new
 Human Malady Compendium 
Biological research products
for CATSPER2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Cation Channel, Sperm Associated 21 2
Cation Channel Sperm-Associated Protein 22
Sperm Ion Channel2
CatSper23

External Ids:    HGNC: 188101   Entrez Gene: 1171552   Ensembl: ENSG000001667627   OMIM: 6072495   UniProtKB: Q96P563   

Export aliases for CATSPER2 gene to outside databases

Previous GC identifers: GC15M039290 GC15M036818 GC15M041501 GC15M041638 GC15M041710 GC15M020752


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CATSPER2:
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation
channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat
with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem
repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Additional splice variants
have been described but their full-length nature has not been determined. (provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: CTSR2_HUMAN, Q96P56
Function: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses
essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the
oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha =
PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more
physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm
capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the
elevation of intracellular pH

Gene Wiki entry for CATSPER2 (CatSper2)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CATSPER2 gene promoter:
         AML1a   AP-2gamma   E47   FOXL1   AP-2beta   Hand1   AP-2alpha   Pax-4a   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCATSPER2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CATSPER2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CATSPER2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.3   Ensembl cytogenetic band:  15q15.3   HGNC cytogenetic band: 15q15.3

CATSPER2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CATSPER2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M043920:  view genomic region     (about GC identifiers)

Start:
43,920,701 bp from pter      End:
43,960,316 bp from pter
Size:
39,616 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CTSR2_HUMAN, Q96P56 (See protein sequence)
Recommended Name: Cation channel sperm-associated protein 2  
Size: 530 amino acids; 62041 Da
Subunit: Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the
CatSper complex. Interacts with Ca(v)3.3/CACNA1I, leading to suppress T-type calcium channel activity
Subcellular location: Cell projection, cilium, flagellum membrane; Multi-pass membrane protein (By similarity).
Note=Specifically located in the principal piece of sperm tail
Secondary accessions: Q8NHT9 Q96P54 Q96P55
Alternative splicing: 4 isoforms:  Q96P56-1   Q96P56-2   Q96P56-3   Q96P56-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CATSPER2: NX_Q96P56

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96P56

  • CATSPER2 Protein expression data from MOPED and PaxDb:    About this image 
    CATSPER2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_473361.1  NP_742093.1  NP_742095.1  

    ENSEMBL proteins: 
     ENSP00000380088   ENSP00000299989   ENSP00000371180   ENSP00000388242   ENSP00000389746  
     ENSP00000408240   ENSP00000407694   ENSP00000386595   ENSP00000399035   ENSP00000321463  
     ENSP00000339137   ENSP00000347613  

    Human Recombinant Protein Products for CATSPER2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CATSPER2
    OriGene Custom Protein Services for CATSPER2 
    GenScript Custom Purified and Recombinant Proteins Services for CATSPER2
    Novus Biologicals CATSPER2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CATSPER2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005929cilium IEA--
    GO:0016021integral to membrane ----
    GO:0036128CatSper complex ISS--

    CATSPER2 for ontologies           About GeneDecksing



    CATSPER2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CATSPER2 
    GenScript Custom Superior Antibodies Services for CATSPER2
    Novus Biologicals CATSPER2 Antibodies
    Search for Antibodies for CATSPER2 at Abcam  
    Uscn Antibodies for CATSPER2
    Search ThermoFisher Antibodies for CATSPER2

    Assay Products for CATSPER2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CATSPER2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CATSPER2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CATSPER2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005821 Ion_trans_dom

    Graphical View of Domain Structure for InterPro Entry Q96P56

    ProtoNet protein and cluster: Q96P56

    UniProtKB/Swiss-Prot: CTSR2_HUMAN, Q96P56
    Similarity: Belongs to the cation channel sperm-associated (TC 1.A.1.19) family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTSR2_HUMAN, Q96P56
    Function: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses
    essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the
    oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha =
    PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more
    physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm
    capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the
    elevation of intracellular pH

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005244voltage-gated ion channel activity IEA--
    GO:0005262calcium channel activity IEA--
    GO:0005515protein binding IPI16740636
         
    CATSPER2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Catsper2):
     reproductive system 

    CATSPER2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Catsper2tm1Gar for CATSPER2
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CATSPER2 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 3): CATSPER2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CATSPER2
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CATSPER2:
    hsa-miR-188-5p hsa-miR-1179 hsa-miR-551b* hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidCATSPER2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CATSPER2 (see all 7)
    OriGene shRNA RFP: CATSPER2
    OriGene siRNA: CATSPER2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CATSPER2
    Sirion Biotech Custom design and validation of potent shRNA sequences against CATSPER2 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CATSPER2
    Sirion Biotech Customized adenovirus for overexpression of CATSPER2 
    Sirion Biotech Customized adenovirus for potent knockdown of CATSPER2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPER2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPER2 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): CATSPER2 (NM_172095)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CATSPER2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CATSPER2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CATSPER2
    Search LifeMap BioReagents cell lines for CATSPER2
    Sirion Biotech Customized stable knockdown cell line services for CATSPER2 
    Sirion Biotech Customized inducible knockdown cell line services for CATSPER2
    Sirion Biotech Customized stable overexpressing cell line services for CATSPER2
    Sirion Biotech Customized inducible overexpressing cell line services for CATSPER2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CATSPER2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sweet Taste Signaling
    Sperm Motility0.36

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CATSPER2
        Sperm Motility


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CATSPER2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for CATSPER2 (Q96P561, 3 ENSP000002999894) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1IQ9P0X41, 3, ENSP000003850194EBI-2215024,EBI-1220829 I2D: score=1 STRING: ENSP00000385019
    AKAP6ENSP000002809794STRING: ENSP00000280979
    CACNA1BENSP000002775494STRING: ENSP00000277549
    CACNA1CENSP000002663764STRING: ENSP00000266376
    CACNA1DENSP000002881394STRING: ENSP00000288139
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001539ciliary or flagellar motility IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0009566fertilization IEA--
    GO:0030154cell differentiation IEA--

    CATSPER2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CATSPER2

    1 HMDB Compound for CATSPER2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about CATSPER2 / CTSR2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CATSPER2 gene (3 alternative transcripts): 
    NM_054020.2  NM_172095.1  NM_172097.1  

    Unigene Cluster for CATSPER2:

    Cation channel, sperm associated 2
    Hs.662284  [show with all ESTs]
    Unigene Representative Sequence: NM_172095
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396879(uc001zsj.3) ENST00000299989 ENST00000381761(uc010bdm.3)
    ENST00000469461(uc001zsh.3 uc001zsi.3) ENST00000450810 ENST00000433380
    ENST00000419262 ENST00000472960 ENST00000415968(uc001zsk.3) ENST00000464721(uc001zsl.1)
    ENST00000432420 ENST00000409481 ENST00000419473 ENST00000321596 ENST00000354127
    ENST00000355438

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 3): CATSPER2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CATSPER2
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CATSPER2:
    hsa-miR-188-5p hsa-miR-1179 hsa-miR-551b* hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidCATSPER2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CATSPER2 (see all 7)
    OriGene shRNA RFP: CATSPER2
    OriGene siRNA: CATSPER2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CATSPER2
    Sirion Biotech Custom design and validation of potent shRNA sequences against CATSPER2 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPER2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPER2 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): CATSPER2 (NM_172095)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CATSPER2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CATSPER2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CATSPER2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CATSPER2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CATSPER2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CATSPER2

    Additional cDNA sequence: 

    AF411817.1 AF411818.1 AF411819.1 AK093318.1 AK122607.1 BC028728.1 BC064387.1 DQ655952.2 

    20 DOTS entries:

    DT.91918714  DT.92418601  DT.75132502  DT.99927566  DT.121025281  DT.100745266  DT.435909  DT.40300693 
    DT.97810571  DT.101982156  DT.121024848  DT.75185162  DT.99961051  DT.100775382  DT.121024832  DT.91944729 
    DT.92418602  DT.99963434  DT.99997855  DT.99965334 

    24/97 AceView cDNA sequences (see all 97):

    AI041252 AI538251 NM_172097 AF411817 NM_172096 BM726174 NM_054020 BM727936 
    BQ003958 AF411819 BU742464 BM717288 NM_172095 AW501136 AF411818 BC064387 
    BU739106 BI826910 BX954860 BX479004 AW472972 BV166894 BX645999 AA393984 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CATSPER2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                                                          -                           
    SP2:                                                                          -                           
    SP3:                                                                          -     -                     
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for CATSPER2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CATSPER2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGGTAAGGA
    CATSPER2 Expression
    About this image
    See CATSPER2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CATSPER2

    SOURCE GeneReport for Unigene cluster: Hs.662284

    UniProtKB/Swiss-Prot: CTSR2_HUMAN, Q96P56
    Tissue specificity: Testis-specific

        SABiosciences Custom PCR Arrays for CATSPER2
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CATSPER2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CATSPER2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CATSPER2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CATSPER2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CATSPER2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CATSPER2 gene from 1/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    CATSPER26
    --

    47(a)
    possible ortholog
    1 ↔ 1
    GL344717.1(29499-38151)
    4(16274636-16276087)


    ENSEMBL Gene Tree for CATSPER2 (if available)
    TreeFam Gene Tree for CATSPER2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CATSPER2 gene
    CATSPER42  CATSPER32  CATSPER12  
    2 SIMAP similar genes for CATSPER2 using alignment to 7 protein entries:     CTSR2_HUMAN (see all proteins):
    SCN3A    SCN5A

    CATSPER2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CATSPER2
    PGOHUM00000246769 PGOHUM00000246770 PGOHUM00000235739


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/396 NCBI SNPs in CATSPER2 are shown (see all 396    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1146856691,2
    F--43922344(+) AGATAG/TGGTCT 2 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1818569361,2
    --43922391(+) CCTAGA/CTTGCT 2 -- ds50010--------
    rs29270721,2
    C,F,A,H--43922398(+) TGCTGT/CAGCCT 2 -- ds500118Minor allele frequency- C:0.31NS EA NA WA CSA 1597
    rs1482841431,2
    --43922405(+) GCCTCC/GAACTC 2 -- ds50010--------
    rs177278531,2
    C,F,H--43922497(+) ACTTGA/CCCTTA 2 -- ds500113Minor allele frequency- C:0.11NA NS EA CSA WA 808
    rs1850604881,2
    --43922522(+) CCTTAG/TCTCAG 2 -- ds50010--------
    rs29157761,2
    C,F,H--43922586(+) CTCACT/CCTGTT 2 -- ds50017Minor allele frequency- C:0.44NA WA CSA 18
    rs1890451601,2
    --43922727(+) TTTTTA/GTATTT 2 -- ds50010--------
    rs1821918131,2
    --43922739(+) TAGTAC/GAGACA 2 -- ds50010--------
    rs1861726801,2
    --43922816(+) TGAATG/TTTTAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CATSPER2 (43920701 - 43960316 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 11 variations for CATSPER2
         11 CNVs: 87664 32029 66780 35314 10482 1282 3079 35315 66782 7061 3960
    Human Gene Mutation Database (HGMD): CATSPER2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CATSPER2
    DNA2.0 Custom Variant and Variant Library Synthesis for CATSPER2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CATSPER2 for disorders           About GeneDecksing

    OMIM gene information: 607249    OMIM disorders: --

    UniProtKB/Swiss-Prot: CTSR2_HUMAN, Q96P56
  • Defects in CATSPER2 are a cause of deafness-infertility syndrome (DIS) [MIM:611102]. DIS is characterized by
  • deafness and infertility and is caused by large contiguous gene deletions at 15q15.3 that removes both STRC and
    CATSPER2 genes

    7 diseases for CATSPER2:    About MalaCards
    deafness-infertility syndrome    congenital dyserythropoietic anemia    male infertility    deafness and male infertility
    dyserythropoietic anemia    infertility    anemia

    2 diseases from the University of Copenhagen DISEASES database for CATSPER2:
    Male infertility     Infertility
    Human Genome Epidemiology (HuGE) Navigator: CATSPER2 (1 document)

    Export disorders for CATSPER2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CATSPER2 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with CATSPER2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A voltage-gated ion channel expressed specifically in spermatozoa. (PubMed id 11675491)1, 2, 3, 9 Quill T.A.... Garbers D.L. (2001)
    2. Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity. (PubMed id 16740636)1, 2 Zhang D.... Gopalakrishnan M. (2006)
    3. International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. (PubMed id 16382101)1, 3 Clapham D.E. and Garbers D.L. (2005)
    4. Progesterone activates the principal Ca2+ channel of human sperm. (PubMed id 21412339)2 Lishko P.V.... Kirichok Y. (2011)
    5. The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. (PubMed id 21412338)2 Strunker T.... Kaupp U.B. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. Sensorineural deafness and male infertility: a contiguous gene deletion syndrome. (PubMed id 17098888)2 Zhang Y.... Smith R.J.H. (2007)
    9. Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility. (PubMed id 17347248)2 Li H.-G.... Xiong C.-L. (2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 117155 HGNC: 18810 AceView: CATSPER2 Ensembl:ENSG00000166762 euGenes: HUgn117155
    ECgene: CATSPER2 H-InvDB: CATSPER2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CATSPER2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CATSPER2 gene:
    Search GeneIP for patents involving CATSPER2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CATSPER2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CATSPER2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CATSPER2  
     OriGene Protein Over-expression Lysate for CATSPER2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CATSPER2   OriGene 3'-UTR Clone for CATSPER2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPER2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CATSPER2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CATSPER2   OriGene Custom Protein Services for CATSPER2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CATSPER2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CATSPER2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CATSPER2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CATSPER2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CATSPER2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CATSPER2
     GenScript Custom Purified and Recombinant Proteins Services for CATSPER2 GenScript cDNA clones with any tag delivered in your preferred vector for CATSPER2
     GenScript Custom Assay Services for CATSPER2 GenScript Custom Superior Antibodies Services for CATSPER2
     GenScript Custom overexpressing Cell Line Services for CATSPER2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CATSPER2 promoter
     Search Chromatin IP Primers for CATSPER2
     RT2 qPCR Primer Assay in human, mouse, rat CATSPER2
     GNC Network for CATSPER2
     SABiosciences PCR Arrays including human, mouse, rat CATSPER2
     Search Tocris compounds for CATSPER2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CATSPER2 antibodies
     CATSPER2 lysates
     Search for Antibodies for CATSPER2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CATSPER2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CATSPER2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CATSPER2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CATSPER2
     SwitchGear 3'UTR luciferase reporter plasmids for CATSPER2
     SwitchGear Promoter luciferase reporter plasmids for CATSPER2
     Search ThermoFisher Antibodies for CATSPER2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CATSPER2
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CATSPER2
    Sirion Biotech Customized:
     stable knockdown cell line services for CATSPER2
     inducible knockdown cell line services for CATSPER2
     design and validation of potent shRNA sequences against CATSPER2
     adenovirus for potent knockdown of CATSPER2
     adenovirus for overexpression of CATSPER2
     stable overexpressing cell line services for CATSPER2
     inducible overexpressing cell line services for CATSPER2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CATSPER2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4