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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CATSPER2 Gene

protein-coding   GIFtS: 54
GCID: GC15M043920

Cation Channel, Sperm Associated 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cation Channel, Sperm Associated 21 2
Cation Channel Sperm-Associated Protein 22
Sperm Ion Channel2
CatSper23

External Ids:    HGNC: 188101   Entrez Gene: 1171552   Ensembl: ENSG000001667627   OMIM: 6072495   UniProtKB: Q96P563   

Export aliases for CATSPER2 gene to outside databases

Previous GC identifers: GC15M039290 GC15M036818 GC15M041501 GC15M041638 GC15M041710 GC15M020752


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CATSPER2 Gene:
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative
cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a
single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is
part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene.
Additional splice variants have been described but their full-length nature has not been determined. (provided by
RefSeq, Aug 2008)

GeneCards Summary for CATSPER2 Gene: 
CATSPER2 (cation channel, sperm associated 2) is a protein-coding gene. Diseases associated with CATSPER2 include catsper-related male infertility, and deafness-infertility syndrome, and among its related super-pathways are Interaction With The Zona Pellucida and Cellular Effects of Sildenafil. GO annotations related to this gene include voltage-gated ion channel activity and calcium channel activity. An important paralog of this gene is CATSPER4.

UniProtKB/Swiss-Prot: CTSR2_HUMAN, Q96P56
Function: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses
essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards
the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone >
PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage
dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors
and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative
shift. Also activated by the elevation of intracellular pH

Gene Wiki entry for CATSPER2 (CatSper2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CATSPER2 gene promoter:
         AML1a   AP-2gamma   E47   FOXL1   AP-2beta   Hand1   AP-2alpha   Pax-4a   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCATSPER2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CATSPER2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CATSPER2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.3   Ensembl cytogenetic band:  15q15.3   HGNC cytogenetic band: 15q15.3

CATSPER2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CATSPER2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M043920:  view genomic region     (about GC identifiers)

Start:
43,920,701 bp from pter      End:
43,960,316 bp from pter
Size:
39,616 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CTSR2_HUMAN, Q96P56 (See protein sequence)
Recommended Name: Cation channel sperm-associated protein 2  
Size: 530 amino acids; 62041 Da
Subunit: Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of
the CatSper complex. Interacts with Ca(v)3.3/CACNA1I, leading to suppress T-type calcium channel activity
Subcellular location: Cell projection, cilium, flagellum membrane; Multi-pass membrane protein (By similarity).
Note=Specifically located in the principal piece of sperm tail
Secondary accessions: Q8NHT9 Q96P54 Q96P55
Alternative splicing: 4 isoforms:  Q96P56-1   Q96P56-2   Q96P56-3   Q96P56-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CATSPER2: NX_Q96P56

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96P56

  • CATSPER2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (5 alternative transcripts): 
    NP_001269238.1  NP_001269239.1  NP_473361.1  NP_742093.1  NP_742095.1  

    ENSEMBL proteins: 
     ENSP00000380088   ENSP00000371180   ENSP00000388242   ENSP00000389746   ENSP00000321463  
     ENSP00000408240   ENSP00000407694   ENSP00000386595   ENSP00000339137   ENSP00000347613  
    Reactome Protein details: Q96P56
    Human Recombinant Protein Products for CATSPER2: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for CATSPER2 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005929cilium ----
    GO:0016020membrane ----
    GO:0016021integral to membrane ----
    GO:0031514motile cilium IEA--

    CATSPER2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CATSPER: Voltage-gated ion channels / Cation channels, sperm associated

    IUPHAR Guide to PHARMACOLOGY protein family classification: CatSper2 
    CatSper and Two-Pore channels

    2 InterPro protein domains:
     IPR005821 Ion_trans_dom
     IPR027359 K_channel_four-helix_dom

    Graphical View of Domain Structure for InterPro Entry Q96P56

    ProtoNet protein and cluster: Q96P56

    UniProtKB/Swiss-Prot: CTSR2_HUMAN, Q96P56
    Similarity: Belongs to the cation channel sperm-associated (TC 1.A.1.19) family


    CATSPER2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTSR2_HUMAN, Q96P56
    Function: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses
    essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards
    the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone >
    PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage
    dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors
    and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative
    shift. Also activated by the elevation of intracellular pH

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005244voltage-gated ion channel activity IEA--
    GO:0005262calcium channel activity IEA--
    GO:0005515protein binding IPI16740636
         
    CATSPER2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Catsper2):
     reproductive system 

    CATSPER2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Catsper2tm1Gar for CATSPER2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CATSPER2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CATSPER2 
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    hsa-miR-188-5p hsa-miR-1179 hsa-miR-551b* hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidCATSPER2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CATSPER2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Fertilization
    Fertilization0.38
    Sperm Motility And Taxes0.35
    Reproduction0.38
    2Sweet Taste Signaling
    Sperm Motility0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CATSPER2
        Sperm Motility

    3        Reactome Pathways for CATSPER2
        Fertilization
    Sperm Motility And Taxes
    Reproduction



    CATSPER2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CATSPER2

    1 Interacting protein for CATSPER2 (Q96P561, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1IQ9P0X41, 3EBI-2215024,EBI-1220829 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001539ciliary or bacterial-type flagellar motility IEA--
    GO:0006811ion transport ----
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0007338single fertilization TAS--

    CATSPER2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CATSPER2 (CTSR2)

    1 HMDB Compound for CATSPER2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    6 IUPHAR Ligands for CATSPER2 (CatSper2)    About this table 
    LigandTypeActionAffinityPubmed IDs
    progesterone
    ActivatorFull agonist8.1121412339 21412338
    PGF
    ActivatorFull agonist6.321412339
    PGE1
    ActivatorFull agonist6.321412339
    PGE2
    ActivatorFull agonist6.321412339
    NNC55-0396
    Pore BlockerInhibition5.721412339 21412338
    mibefradil
    Pore BlockerInhibition4.4 - 4.5221412338

    Search CenterWatch for drugs/clinical trials and news about CATSPER2 / CTSR2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CATSPER2 gene (5 alternative transcripts): 
    NM_001282309.1  NM_001282310.1  NM_054020.3  NM_172095.2  NM_172097.1  

    Unigene Cluster for CATSPER2:

    Cation channel, sperm associated 2
    Hs.662284  [show with all ESTs]
    Unigene Representative Sequence: NM_172095
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396879(uc001zsj.3) ENST00000381761(uc010bdm.3) ENST00000469461(uc001zsh.3 uc001zsi.3)
    ENST00000450810 ENST00000433380 ENST00000321596 ENST00000419262 ENST00000472960
    ENST00000415968(uc001zsk.3) ENST00000464721(uc001zsl.1) ENST00000432420
    ENST00000409481 ENST00000354127 ENST00000355438
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    Additional mRNA sequence: 

    AF411817.1 AF411818.1 AF411819.1 AK093318.1 AK122607.1 BC028728.1 BC064387.1 DQ655952.2 

    20 DOTS entries:

    DT.91918714  DT.92418601  DT.75132502  DT.99927566  DT.121025281  DT.100745266  DT.435909  DT.40300693 
    DT.97810571  DT.101982156  DT.121024848  DT.99961051  DT.100775382  DT.121024832  DT.91944729  DT.92418602 
    DT.99963434  DT.99997855  DT.97765798  DT.99965334 

    24/97 AceView cDNA sequences (see all 97):

    BM727936 NM_054020 BC064387 NM_172096 NM_172095 AI538251 BU739106 AF411818 
    AW501136 BI826910 NM_172097 AF411819 BM726174 AF411817 BM717288 BU742464 
    BQ003958 AI041252 CD635523 BM998110 AK122607 BE614225 CD635522 AW472972 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CATSPER2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                                                          -                           
    SP2:                                                                          -                           
    SP3:                                                                          -     -                     
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for CATSPER2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CATSPER2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTAAGGA
    CATSPER2 Expression
    About this image


    Genevestigator expression for CATSPER2

    SOURCE GeneReport for Unigene cluster: Hs.662284

    UniProtKB/Swiss-Prot: CTSR2_HUMAN, Q96P56
    Tissue specificity: Testis-specific

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CATSPER2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CATSPER2 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Catsper21 , 5 cation channel, sperm associated 21, 5 74.49(n)1
    69.47(a)1
      2 (60.38 cM)5
    2126701  NM_153075.31  NP_694715.21 
     1213926315 
    lizard
    (Anolis carolinensis)
    Reptilia CATSPER26
    Uncharacterized protein
    47(a)
    1 ↔ 1
    4(16274636-16276087)


    ENSEMBL Gene Tree for CATSPER2 (if available)
    TreeFam Gene Tree for CATSPER2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CATSPER2 gene
    CATSPER42  CATSPER32  
    2 SIMAP similar genes for CATSPER2 using alignment to 7 protein entries:     CTSR2_HUMAN (see all proteins):
    SCN3A    SCN5A

    CATSPER2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CATSPER2
    PGOHUM00000246769 PGOHUM00000246770 PGOHUM00000235739


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/11 SNPs in CATSPER2 are shown (see all 11)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
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    ----------
    VAR_0333084
    ----see VAR_0333082 V I mis40--------
    VAR_0333074
    ----see VAR_0333072 E G mis40--------
    rs590981091,2
    C--43925307(+) ATCCT-/TATAACT 2 -- int10--------
    rs572379321,2
    C--43929032(+) TTTTT-/TGAGAC 2 -- int10--------
    rs714158041,2
    C--43931619(+) TTTTT-/T/TT  
            
    TTTTT
    2 -- int11NA 2
    rs1995728191,2
    C--43933320(+) TTTTT-/TGAGAT 3 -- int10--------
    rs784372901,2
    ----43931607(+) CCGGCT/AATTTT 3 -- int1 ds50011Minor allele frequency- A:0.00NA 2
    rs760046221,2
    ----43931613(+) ATTTTA/TTTTTT 3 -- int1 ds50011Minor allele frequency- T:0.00NA 2
    rs756110051,2
    ----43931614(+) TTTTTA/TTTTTT 3 -- int1 ds50011Minor allele frequency- T:0.00NA 2
    rs3753373931,2
    ----43938517(+) CAGTG-/GCGTGA 3 -- int10--------

    HapMap Linkage Disequilibrium report for CATSPER2 (43920701 - 43960316 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/26 variations for CATSPER2 (see all 26):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749626CNV Deletion23290073
    esv2421427CNV Deletion20811451
    nsv1514CNV Loss18451855
    nsv904172CNV Loss21882294
    dgv2374n71CNV Loss21882294
    nsv817690CNV Loss17921354
    dgv2373n71CNV Loss21882294
    nsv428304CNV Loss18775914
    dgv146n21CNV Loss19592680
    esv33424CNV Loss17666407


    Human Gene Mutation Database (HGMD): CATSPER2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CATSPER2
    DNA2.0 Custom Variant and Variant Library Synthesis for CATSPER2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607249    OMIM disorders: --

    UniProtKB/Swiss-Prot: CTSR2_HUMAN, Q96P56
  • Deafness-infertility syndrome (DIS) [MIM:611102]: Characterized by deafness and infertility and is caused
    by large contiguous gene deletions at 15q15.3 that removes both STRC and CATSPER2 genes. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 6 diseases for CATSPER2:    About MalaCards
    catsper-related male infertility    deafness-infertility syndrome    male infertility    congenital dyserythropoietic anemia
    infertility    anemia

    1 disease from the University of Copenhagen DISEASES database for CATSPER2:
    Male infertility

    CATSPER2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CATSPER2
    Human Genome Epidemiology (HuGE) Navigator: CATSPER2 (1 document)

    Export disorders for CATSPER2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CATSPER2 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with CATSPER2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A voltage-gated ion channel expressed specifically in spermatozoa. (PubMed id 11675491)1, 2, 3, 9 Quill T.A.... Garbers D.L. (2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity. (PubMed id 16740636)1, 2 Zhang D.... Gopalakrishnan M. (2006)
    4. International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. (PubMed id 16382101)1, 3 Clapham D.E. and Garbers D.L. (2005)
    5. Progesterone activates the principal Ca2+ channel of human sperm. (PubMed id 21412339)2 Lishko P.V.... Kirichok Y. (2011)
    6. The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. (PubMed id 21412338)2 Strunker T.... Kaupp U.B. (2011)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. Sensorineural deafness and male infertility: a contiguous gene deletion syndrome. (PubMed id 17098888)2 Zhang Y.... Smith R.J.H. (2007)
    9. Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility. (PubMed id 17347248)2 Li H.-G.... Xiong C.-L. (2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 117155 HGNC: 18810 AceView: CATSPER2 Ensembl:ENSG00000166762 euGenes: HUgn117155
    ECgene: CATSPER2 H-InvDB: CATSPER2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CATSPER2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CATSPER2 gene:
    Search GeneIP for patents involving CATSPER2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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