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CATSPER1 Gene

protein-coding   GIFtS: 56
GCID: GC11M065784

Cation Channel, Sperm Associated 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cation Channel, Sperm Associated 11 2     Cation Channel Sperm-Associated Protein 12
hCatSper2 3     Sperm Ion Channel2
CATSPER2 5     Sperm-Associated Cation Channel 12
SPGF72 5     CatSper13

External Ids:    HGNC: 171161   Entrez Gene: 1171442   Ensembl: ENSG000001752947   OMIM: 6063895   UniProtKB: Q8NEC53   

Export aliases for CATSPER1 gene to outside databases

Previous GC identifers: GC11M068318 GC11M067465 GC11M066034 GC11M065559 GC11M065540 GC11M062110


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CATSPER1 Gene:
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative
cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a
single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CATSPER1 Gene:
CATSPER1 (cation channel, sperm associated 1) is a protein-coding gene. Diseases associated with CATSPER1 include rhinotracheitis, and spermatogenic failure 7. GO annotations related to this gene include voltage-gated calcium channel activity.

UniProtKB/Swiss-Prot: CTSR1_HUMAN, Q8NEC5
Function: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses
essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards
the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone >
PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage
dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors
and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative
shift. Also activated by the elevation of intracellular pH

Gene Wiki entry for CATSPER1 (CatSper1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CATSPER1 gene promoter:
         Max1   NF-1/L   NF-1   Elk-1   Pax-5   E47   STAT3   Hand1   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCATSPER1 promoter sequence
   Search Chromatin IP Primers for CATSPER1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CATSPER1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q12.1

CATSPER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CATSPER1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M065784:  view genomic region     (about GC identifiers)

Start:
65,784,223 bp from pter      End:
65,793,988 bp from pter
Size:
9,766 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CTSR1_HUMAN, Q8NEC5 (See protein sequence)
Recommended Name: Cation channel sperm-associated protein 1  
Size: 780 amino acids; 90091 Da
Subunit: Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of
the CatSper complex. Interacts with CATSPER3 and CATSPER4 (By similarity). Interacts with Ca(v)3.3/CACNA1I,
leading to suppress T-type calcium channel activity
Developmental stage: Expressed meiotically and post-meiotically
Secondary accessions: Q96P76

Explore the universe of human proteins at neXtProt for CATSPER1: NX_Q8NEC5

Explore proteomics data for CATSPER1 at MOPED


See CATSPER1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_444282.3  
ENSEMBL proteins: 
 ENSP00000309052  
Reactome Protein details: Q8NEC5

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
CATSPER: Voltage-gated ion channels / Cation channels, sperm associated

IUPHAR Guide to PHARMACOLOGY protein family classification: CatSper1
CatSper and Two-Pore channels

3 InterPro protein domains:
 IPR005821 Ion_trans_dom
 IPR027359 Channel_four-helix_dom
 IPR028746 CatSper1

Graphical View of Domain Structure for InterPro Entry Q8NEC5

ProtoNet protein and cluster: Q8NEC5

UniProtKB/Swiss-Prot: CTSR1_HUMAN, Q8NEC5
Similarity: Belongs to the cation channel sperm-associated (TC 1.A.1.19) family


CATSPER1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CTSR1_HUMAN, Q8NEC5
Function: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses
essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards
the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone >
PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage
dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors
and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative
shift. Also activated by the elevation of intracellular pH
Induction: Down-regulated in patients lacking sperm motility

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005216ion channel activity ----
GO:0005227calcium activated cation channel activity IEA--
GO:0005245voltage-gated calcium channel activity IEA--
GO:0005515protein binding IPI16740636
     
CATSPER1 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for CATSPER1:
 Synthetic lethal with Ras 

     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Catsper1):
 homeostasis/metabolism  reproductive system 

CATSPER1 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Catsper1tm1Clph for CATSPER1

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CATSPER1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CATSPER1

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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CATSPER1

miRNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CTSR1_HUMAN, Q8NEC5: Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically
located in the principal piece of sperm tail
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane4
nucleus2
endoplasmic reticulum1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0005929cilium IEA--
GO:0016020membrane ----
GO:0036128CatSper complex ISS--

CATSPER1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CATSPER1 About    
See pathways by source

SuperPathContained pathways About
1Reproduction
Reproduction1.00
Sperm Motility And Taxes0.00
Fertilization1.00
2Sweet Taste Signaling
Sperm Motility0.37
3Sodium channels and transporters inward current
Sodium channels and transporters inward current

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CATSPER1
    Sperm Motility


1 Reactome Pathway for CATSPER1
    Sperm Motility And Taxes



CATSPER1 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CATSPER1
Interactions:

    GeneGlobe Interaction Network for CATSPER1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CATSPER1 (Q8NEC51, 2, 3 ENSP000003090524) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
InteractantInteraction Details
GeneCardExternal ID(s)
EFEMP2O959672, 3, ENSP000003099534MINT-66532 I2D: score=3 STRING: ENSP00000309953
CACNA1IQ9P0X41, 3, ENSP000003850194EBI-744545,EBI-1220829 I2D: score=1 STRING: ENSP00000385019
CHIC2Q9UKJ52, 3, ENSP000002639214MINT-68252 I2D: score=4 STRING: ENSP00000263921
KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-68285 I2D: score=4 STRING: ENSP00000377582
TRIP6Q156542, 3, ENSP000002004574MINT-67180 I2D: score=4 STRING: ENSP00000200457
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Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001539cilium or flagellum-dependent cell motility IEA--
GO:0006811ion transport ----
GO:0006816calcium ion transport ----
GO:0007275multicellular organismal development IEA--
GO:0007283spermatogenesis IEA--

CATSPER1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CATSPER1 (CTSR1)

1 HMDB Compound for CATSPER1    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--

10 IUPHAR Ligands for CATSPER1 (CatSper1)    About this table
LigandTypeActionAffinityPubmed IDs
progesterone
ActivatorFull agonist8 - 8.1121412339 21412338
PGF1alpha
ActivatorFull agonist6.321412339
PGE1
ActivatorFull agonist6.321412339
PGE2
ActivatorFull agonist6.321412339
NNC55-0396
Pore BlockerInhibition5.721412339 21412338
ruthenium red
Channel blockerNone5--
HC056456
Channel blockerNone4.7--
mibefradil
Pore BlockerInhibition4.4 - 4.5221412338
Cd2+
Channel blockerNone3.7--
Ni2+
Channel blockerNone3.5--

1 Novoseek inferred chemical compound relationship for CATSPER1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
calcium 27.7 2 16467839 (1)



CATSPER1 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CATSPER1 gene: 
NM_053054.3  

Unigene Cluster for CATSPER1:

Cation channel, sperm associated 1
Hs.189105  [show with all ESTs]
Unigene Representative Sequence: NM_053054
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000312106(uc001ogt.3) ENST00000529244
miRNA
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GenScript: all cDNA clones in your preferred vector: CATSPER1 (NM_053054)
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Primer
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  QuantiFast Probe-based Assays in human, mouse, rat CATSPER1

Additional mRNA sequence: 

AF407333.1 BC032950.2 BC036522.2 

1 DOTS entry:

DT.100019352 

Selected AceView cDNA sequences (see all 29):

AF407333 BU631501 BU601108 BI463921 AA416682 BQ433031 BC036522 BC032950 
NM_053054 BM559902 BG719591 CD635486 AA416577 BM987175 CD635482 CD635487 
CD635484 CD635489 AA884212 CD635494 CD635491 CD635485 CD635492 CD635490 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CATSPER1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACTGAGAAGC
CATSPER1 Expression
About this image


CATSPER1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 NULL (Uncategorized)
         CD31, CD144 positive cells
 
 Testis (Reproductive System)
CATSPER1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CATSPER1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.189105

UniProtKB/Swiss-Prot: CTSR1_HUMAN, Q8NEC5
Tissue specificity: Testis-specific

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CATSPER1 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Catsper11 , 5 cation channel, sperm associated 11, 5 67.97(n)1
58.79(a)1
  19 (4.30 cM)5
2258651  NM_139301.21  NP_647462.11 
 53357415 
lizard
(Anolis carolinensis)
Reptilia CATSPER16
cation channel, sperm associated 1
47(a)
1 ↔ 1
GL343832.1(42690-59142)


ENSEMBL Gene Tree for CATSPER1 (if available)
TreeFam Gene Tree for CATSPER1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CATSPER1 gene
2 SIMAP similar genes for CATSPER1 using alignment to 1 protein entry:     CTSR1_HUMAN:
SCN5A    SCN3A

CATSPER1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CATSPER1 (see all 407)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs5484951,2
C,F--65703895(+) TGGGGC/TTCTAG 1 -- ds50016Minor allele frequency- T:0.28NA WA EA 364
rs125766021,2
C,F,H--65703940(+) ACCTCC/TGACCT 1 -- ds50011Minor allele frequency- T:0.33NA 6
rs6682101,2
C,F,H--65704073(-) ACCCCG/AGGGTT 1 -- ds500123Minor allele frequency- A:0.35MN NS EA NA WA CSA 2535
rs1384743941,2
--65704100(+) TTTCTC/TCTGAC 1 -- ds50010--------
rs1402502621,2
C--65704162(+) CCCTC-/CCG   
  GCACCG
CCGGC
1 -- ds50010--------
rs1995796671,2
C--65704169(+) GGCACC/TGCCGG 1 -- ds50010--------
rs1906996471,2
--65704192(+) GCCCAC/TGTTCT 1 -- ds50010--------
rs1830371261,2
--65704210(+) CCCTCC/TAGCTG 1 -- ds50010--------
rs1142643151,2
F--65704223(+) GCTAAT/CGCCCT 1 -- ds50011Minor allele frequency- C:0.03WA 118
rs1430972231,2
C--65704302(+) CAACAC/TGGGCA 1 -- ds50010--------

HapMap Linkage Disequilibrium report for CATSPER1 (65784223 - 65793988 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for CATSPER1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv825954CNV Loss20364138
dgv1186n71CNV Loss21882294
nsv832191CNV Loss17160897

Human Gene Mutation Database (HGMD): CATSPER1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CATSPER1
DNA2.0 Custom Variant and Variant Library Synthesis for CATSPER1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606389   
OMIM disorders: 612997  
UniProtKB/Swiss-Prot: CTSR1_HUMAN, Q8NEC5
  • Spermatogenic failure 7 (SPGF7) [MIM:612997]: An infertility disorder characterized by non-motile sperm
    or sperm motility below the normal threshold, low sperm count, increased abnormally structured spermatozoa, and
    reduced semen volume. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 9 diseases for CATSPER1:    
    About MalaCards
    rhinotracheitis    spermatogenic failure 7    catsper-related nonsyndromic male infertility    catsper-related male infertility
    male infertility    infertility    multiple myeloma    myeloma
    endotheliitis

    2 diseases from the University of Copenhagen DISEASES database for CATSPER1:
    Rhinotracheitis     Male infertility

    CATSPER1 for disorders           About GeneDecksing


    Export disorders for CATSPER1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CATSPER1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with CATSPER1)
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    1. A sperm ion channel required for sperm motility and male fertility. (PubMed id 11595941)1, 2, 3 Ren D.... Clapham D.E. (Nature 2001)
    2. The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa. (PubMed id 16625279)1, 2, 9 Li H.-G.... Xiong C.-L. (Asian J. Androl. 2006)
    3. Human male infertility caused by mutations in the CATSPER1 channel protein. (PubMed id 19344877)1, 2, 9 Avenarius M.R.... Smith R.J.H. (Am. J. Hum. Genet. 2009)
    4. Progesterone activates the principal Ca2+ channel of human sperm. (PubMed id 21412339)1, 2 Lishko P.V.... Kirichok Y. (Nature 2011)
    5. The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. (PubMed id 21412338)1, 2 Strunker T.... Kaupp U.B. (Nature 2011)
    6. Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity. (PubMed id 16740636)1, 2 Zhang D.... Gopalakrishnan M. (J. Biol. Chem. 2006)
    7. International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. (PubMed id 16382101)1, 3 Clapham D.E. and Garbers D.L. (Pharmacol. Rev. 2005)
    8. CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility. (PubMed id 14688170)1, 2 Nikpoor P.... Tiraihi T. (Hum. Reprod. 2004)
    9. A voltage-gated ion channel expressed specifically in spermatozoa. (PubMed id 11675491)1, 3 Quill T.A.... Garbers D.L. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    10. Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility. (PubMed id 17347248)2, 9 Li H.-G.... Xiong C.-L. (Mol. Hum. Reprod. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 117144 HGNC: 17116 AceView: CATSPER1 Ensembl:ENSG00000175294 euGenes: HUgn117144
    ECgene: CATSPER1 H-InvDB: CATSPER1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CATSPER1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CATSPER1 gene:
    Search GeneIP for patents involving CATSPER1

    GeneCards and IP:
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