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Aliases for CATIP Gene

Aliases for CATIP Gene

  • Ciliogenesis Associated TTC17 Interacting Protein 2 3 5
  • C2orf62 3 4
  • Ciliogenesis-Associated TTC17-Interacting Protein 3
  • Chromosome 2 Open Reading Frame 62 2

External Ids for CATIP Gene

Previous HGNC Symbols for CATIP Gene

  • C2orf62

Previous GeneCards Identifiers for CATIP Gene

  • GC02P219222

Summaries for CATIP Gene

GeneCards Summary for CATIP Gene

CATIP (Ciliogenesis Associated TTC17 Interacting Protein) is a Protein Coding gene. GO annotations related to this gene include calmodulin binding.

UniProtKB/Swiss-Prot for CATIP Gene

  • Plays a role in primary ciliogenesis by modulating actin polymerization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CATIP Gene

Genomics for CATIP Gene

Regulatory Elements for CATIP Gene

Enhancers for CATIP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F218359 0.6 Ensembl ENCODE 13.3 +5.2 5168 5.2 PKNOX1 SIN3A ZNF48 SLC30A9 ZNF766 ZNF207 ZNF263 REST CREB3 SREBF1 CATIP ENSG00000261338 PNKD CFAP65 CATIP-AS2 CATIP-AS1
GH02F218310 0.7 Ensembl 5 -47.8 -47832 0.8 ZNF366 ENSG00000261338 PNKD AAMP SLC11A1 CATIP LOC105373880 MIR6513 TMBIM1
GH02F218381 1.1 Ensembl ENCODE 4.9 +26.6 26572 4.0 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TMBIM1 MIR6513 AAMP PNKD SLC11A1 CATIP CTDSP1
GH02F218366 1.3 FANTOM5 ENCODE 4.7 +13.0 13044 6.8 HDGF TBP HDAC1 ATF1 CBX3 TBL1XR1 CREB3L1 RAD21 ZBTB40 ETS1 SLC11A1 ENSG00000261338 ARPC2 CXCR2 CXCR1 CATIP PNKD CNOT9 TMBIM1 USP37
GH02F217371 1.1 Ensembl 4.4 -984.8 -984832 0.4 POLR2A CATIP GC02M217383 GC02P217334
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CATIP on UCSC Golden Path with GeneCards custom track

Genomic Location for CATIP Gene

Chromosome:
2
Start:
218,356,832 bp from pter
End:
218,368,110 bp from pter
Size:
11,279 bases
Orientation:
Plus strand

Genomic View for CATIP Gene

Genes around CATIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CATIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CATIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATIP Gene

Proteins for CATIP Gene

  • Protein details for CATIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7H3-CATIP_HUMAN
    Recommended name:
    Ciliogenesis-associated TTC17-interacting protein
    Protein Accession:
    Q7Z7H3

    Protein attributes for CATIP Gene

    Size:
    387 amino acids
    Molecular mass:
    43900 Da
    Quaternary structure:
    • Interacts with TTC17.

neXtProt entry for CATIP Gene

Post-translational modifications for CATIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CATIP Gene

Antibody Products

No data available for DME Specific Peptides for CATIP Gene

Domains & Families for CATIP Gene

Protein Domains for CATIP Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z7H3

UniProtKB/Swiss-Prot:

CATIP_HUMAN :
  • Belongs to the CATIP family.
Family:
  • Belongs to the CATIP family.
genes like me logo Genes that share domains with CATIP: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CATIP Gene

Function for CATIP Gene

Molecular function for CATIP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in primary ciliogenesis by modulating actin polymerization.

Gene Ontology (GO) - Molecular Function for CATIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24475127
genes like me logo Genes that share ontologies with CATIP: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CATIP Gene

Localization for CATIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CATIP Gene

Nucleus. Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized with TTC17 at F-actin rich zones and at dynamic plasma membrane protrusions.

Gene Ontology (GO) - Cellular Components for CATIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 24475127
GO:0005737 cytoplasm IEA,IDA 24475127
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA,IDA 24475127
GO:0015629 actin cytoskeleton IDA 24475127
genes like me logo Genes that share ontologies with CATIP: view

No data available for Subcellular locations from COMPARTMENTS for CATIP Gene

Pathways & Interactions for CATIP Gene

SuperPathways for CATIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for CATIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:0030041 actin filament polymerization IMP 24475127
GO:0044782 cilium organization IMP 24475127
genes like me logo Genes that share ontologies with CATIP: view

No data available for Pathways by source and SIGNOR curated interactions for CATIP Gene

Transcripts for CATIP Gene

mRNA/cDNA for CATIP Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CATIP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: - - -
SP3:
SP4:

Relevant External Links for CATIP Gene

GeneLoc Exon Structure for
CATIP
ECgene alternative splicing isoforms for
CATIP

Expression for CATIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CATIP Gene

mRNA differential expression in normal tissues according to GTEx for CATIP Gene

This gene is overexpressed in Testis (x7.5), Whole Blood (x5.7), Kidney - Cortex (x4.8), Fallopian Tube (x4.3), and Thyroid (x4.2).

Protein differential expression in normal tissues from HIPED for CATIP Gene

This gene is overexpressed in Bone marrow stromal cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CATIP Gene



Protein tissue co-expression partners for CATIP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CATIP Gene:

CATIP

mRNA Expression by UniProt/SwissProt for CATIP Gene:

Q7Z7H3-CATIP_HUMAN
Tissue specificity: Strongly expressed in round and elongating spermatids, weakly in pachytene spermatocytes. Expressed in Leydig cells (at protein level). Expressed in testis, placenta, prostate and lung, and moderately in ovary and brain.
genes like me logo Genes that share expression patterns with CATIP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CATIP Gene

Orthologs for CATIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CATIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CATIP 34
  • 99.48 (n)
C2orf62 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CATIP 34
  • 84.96 (n)
C2orf62 35
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC690437 34
  • 78.66 (n)
dog
(Canis familiaris)
Mammalia C2orf62 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C2orf62 35
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm216 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves CATIP 34
  • 54.44 (n)
C2orf62 35
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C2orf62 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495462 34
  • 55.52 (n)
zebrafish
(Danio rerio)
Actinopterygii catip 34
  • 54.12 (n)
C6H2orf62 35
  • 40 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToOne
Species where no ortholog for CATIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CATIP Gene

ENSEMBL:
Gene Tree for CATIP (if available)
TreeFam:
Gene Tree for CATIP (if available)

Paralogs for CATIP Gene

No data available for Paralogs for CATIP Gene

Variants for CATIP Gene

Sequence variations from dbSNP and Humsavar for CATIP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10172824 -- 218,357,400(+) CTGTC(C/T)GTGCC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs10570162 -- 218,359,818(+) GCTGC(-/TT)TTTTT intron-variant, upstream-variant-2KB
rs10804268 -- 218,355,117(+) ctgcc(A/G)tactc intron-variant, upstream-variant-2KB
rs111279594 -- 218,355,182(+) CTAAA(A/G)TCTTT intron-variant, upstream-variant-2KB
rs111348286 -- 218,358,997(+) GTCGG(A/G)AGTTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CATIP Gene

Variant ID Type Subtype PubMed ID
esv2763102 CNV loss 21179565
nsv519829 CNV loss 19592680

Variation tolerance for CATIP Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CATIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CATIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATIP Gene

Disorders for CATIP Gene

Relevant External Links for CATIP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CATIP

No disorders were found for CATIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATIP Gene

Publications for CATIP Gene

  1. C2orf62 and TTC17 Are Involved in Actin Organization and Ciliogenesis in Zebrafish and Human. (PMID: 24475127) Bontems F. … Lane L. (PLoS ONE 2014) 2 3 4 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64

Products for CATIP Gene

Sources for CATIP Gene

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