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Aliases for CAT Gene

Aliases for CAT Gene

  • Catalase 2 3 5
  • EC 4 63

External Ids for CAT Gene

Previous GeneCards Identifiers for CAT Gene

  • GC11P036013
  • GC11P035138
  • GC11P034499
  • GC11P034424
  • GC11P034417
  • GC11P034157

Summaries for CAT Gene

Entrez Gene Summary for CAT Gene

  • This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for CAT Gene

CAT (Catalase) is a Protein Coding gene. Diseases associated with CAT include acatalasemia and pneumoconiosis. Among its related pathways are Metabolism and Cellular Senescence. GO annotations related to this gene include protein homodimerization activity and enzyme binding.

UniProtKB/Swiss-Prot for CAT Gene

  • Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.

Gene Wiki entry for CAT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAT Gene

Genomics for CAT Gene

Regulatory Elements for CAT Gene

Promoters for CAT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAT on UCSC Golden Path with GeneCards custom track

Genomic Location for CAT Gene

34,438,925 bp from pter
34,472,062 bp from pter
33,138 bases
Plus strand

Genomic View for CAT Gene

Genes around CAT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAT Gene

Proteins for CAT Gene

  • Protein details for CAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K6C0
    • B2RCZ9
    • D3DR07
    • Q2M1U4
    • Q4VXX5
    • Q9BWT9
    • Q9UC85

    Protein attributes for CAT Gene

    527 amino acids
    Molecular mass:
    59756 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Name=NADP(+); Xref=ChEBI:CHEBI:58349;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for CAT Gene

neXtProt entry for CAT Gene

Proteomics data for CAT Gene at MOPED

Post-translational modifications for CAT Gene

Other Protein References for CAT Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CAT (Catalase)

Domains & Families for CAT Gene

Suggested Antigen Peptide Sequences for CAT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the catalase family.
  • Belongs to the catalase family.
genes like me logo Genes that share domains with CAT: view

No data available for Gene Families for CAT Gene

Function for CAT Gene

Molecular function for CAT Gene

GENATLAS Biochemistry:
catalase,60kDa,peroxisomal,expressed in erythrocytes,liver,kidney,catabolic pathway of activated oxygen species,free radical detoxification
UniProtKB/Swiss-Prot CatalyticActivity:
2 H(2)O(2) = O(2) + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.

Enzyme Numbers (IUBMB) for CAT Gene

Gene Ontology (GO) - Molecular Function for CAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016209 antioxidant activity IDA 10514471
genes like me logo Genes that share ontologies with CAT: view
genes like me logo Genes that share phenotypes with CAT: view

Human Phenotype Ontology for CAT Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CAT Gene

MGI Knock Outs for CAT:

Animal Model Products

miRNA for CAT Gene

No data available for Transcription Factor Targets and HOMER Transcription for CAT Gene

Localization for CAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAT Gene


Subcellular locations from

Jensen Localization Image for CAT Gene COMPARTMENTS Subcellular localization image for CAT gene
Compartment Confidence
cytosol 5
extracellular 5
peroxisome 5
mitochondrion 4
plasma membrane 4
endoplasmic reticulum 3
lysosome 3
nucleus 3
vacuole 3
chloroplast 2
cytoskeleton 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IBA --
GO:0005778 peroxisomal membrane IEA,ISS --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with CAT: view

Pathways & Interactions for CAT Gene

genes like me logo Genes that share pathways with CAT: view

SIGNOR curated interactions for CAT Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0001649 osteoblast differentiation IDA 16210410
GO:0001666 response to hypoxia IEA --
GO:0001822 kidney development IEA --
GO:0006144 purine nucleobase metabolic process TAS --
genes like me logo Genes that share ontologies with CAT: view

Drugs & Compounds for CAT Gene

(66) Drugs for CAT Gene - From: Novoseek, HMDB, PharmGKB, ClinicalTrials, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fomepizole Approved Pharma Target, inhibitor 3
Ethanol Approved Pharma 1839
3-hydroxyanthranilic acid Experimental Pharma 0
Formaldehyde Experimental Pharma 73
anthracyclines and related substances Pharma 0

(93) Additional Compounds for CAT Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
  • Dioxidanidyl
  • Dioxide(1-)
  • Hyperoxid
  • Superoxide
  • Superoxide anion
  • 2-Amino-3-oxo-3H-phenoxazin-1,9-dicarboxylic acid
  • 2-Amino-3H-phenoxazin-one-1,9-dicarboxylic acid
  • Cinnabarinic acid
  • Cinnavalininic acid
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
  • Alcool methylique
  • Alcool metilico
  • Carbinol
  • CH3OH
  • Colonial spirit
genes like me logo Genes that share compounds with CAT: view

Transcripts for CAT Gene

Unigene Clusters for CAT Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAT Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -
SP8: - - - - - -
SP10: -
SP12: -

ExUns: 13a · 13b

Relevant External Links for CAT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAT Gene

mRNA expression in normal human tissues for CAT Gene

mRNA differential expression in normal tissues according to GTEx for CAT Gene

This gene is overexpressed in Liver (x5.5) and Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for CAT Gene

This gene is overexpressed in Liver, secretome (13.7) and Liver (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAT Gene

SOURCE GeneReport for Unigene cluster for CAT Gene Hs.502302

genes like me logo Genes that share expression patterns with CAT: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CAT Gene

Orthologs for CAT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAT Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CAT 35
  • 89.75 (n)
  • 91.46 (a)
CAT 36
  • 91 (a)
(Canis familiaris)
Mammalia CAT 35
  • 89.69 (n)
  • 91.65 (a)
-- 36
  • 79 (a)
CAT 36
  • 92 (a)
(Mus musculus)
Mammalia Cat 35
  • 85.9 (n)
  • 89.37 (a)
Cat 16
Cat 36
  • 89 (a)
(Pan troglodytes)
Mammalia CAT 35
  • 99.43 (n)
  • 99.43 (a)
CAT 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cat 35
  • 85.14 (n)
  • 88.99 (a)
(Monodelphis domestica)
Mammalia CAT 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
-- 36
  • 72 (a)
(Gallus gallus)
Aves CAT 35
  • 81.74 (n)
  • 88.26 (a)
CAT 36
  • 83 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
-- 36
  • 73 (a)
-- 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cat.2 35
  • 73.81 (n)
  • 81.97 (a)
African clawed frog
(Xenopus laevis)
Amphibia cat-prov 35
(Danio rerio)
Actinopterygii cat 35
  • 72.17 (n)
  • 78.31 (a)
cat 36
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cat 37
  • 66 (a)
CG9314 37
  • 59 (a)
Cat 35
  • 63.39 (n)
  • 66.73 (a)
Cat 36
  • 66 (a)
CG9314 36
  • 58 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta CAT1 35
  • 62.46 (n)
  • 68.23 (a)
(Caenorhabditis elegans)
Secernentea Y54G11A.13 37
  • 62 (a)
ctl-2 35
  • 62.46 (n)
  • 64.15 (a)
ctl-1 36
  • 62 (a)
ctl-2 36
  • 64 (a)
ctl-3 36
  • 60 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL256W 35
  • 54.42 (n)
  • 51.77 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D11660g 35
  • 53.8 (n)
  • 52.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTA1 35
  • 53.18 (n)
  • 51.15 (a)
CTA1 36
  • 48 (a)
CTA1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CAT1 35
  • 53.57 (n)
  • 46.5 (a)
(Glycine max)
eudicotyledons Gma.2444 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7958 35
(Hordeum vulgare)
Liliopsida Hv.108 35
(Oryza sativa)
Liliopsida Os.156 35
Os03g0131200 35
  • 52.45 (n)
  • 46.75 (a)
(Triticum aestivum)
Liliopsida Ta.28032 35
(Zea mays)
Liliopsida Zm.6357 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05169 35
  • 51.74 (n)
  • 47.07 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ctt1 35
  • 54.44 (n)
  • 52.08 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4587 36
  • 66 (a)
Species with no ortholog for CAT:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CAT Gene

Gene Tree for CAT (if available)
Gene Tree for CAT (if available)

Paralogs for CAT Gene

No data available for Paralogs for CAT Gene

Variants for CAT Gene

Sequence variations from dbSNP and Humsavar for CAT Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs14527 -- 34,471,977(+) TACAT(C/T)AATGT utr-variant-3-prime
rs475043 -- 34,472,254(-) AAGTT(A/G)GGGCA downstream-variant-500B
rs486256 -- 34,445,477(-) GCTCT(A/G)TTGCC intron-variant
rs508370 -- 34,466,548(-) cgccc(A/G)cctca intron-variant
rs499406 -- 34,470,394(-) aaccc(A/C/G)caact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAT Gene

Variant ID Type Subtype PubMed ID
dgv1068n71 CNV Gain 21882294
dgv1069n71 CNV Gain 21882294
nsv832114 CNV Gain 17160897
nsv825835 CNV Gain 20364138

Variation tolerance for CAT Gene

Residual Variation Intolerance Score: 31.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAT Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAT Gene

Disorders for CAT Gene

MalaCards: The human disease database

(62) MalaCards diseases for CAT Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • acatalasia
pityriasis versicolor
  • infection by pityrosporum furfur
meningitis and encephalitis
congenital rubella
  • craniosynostosis
- elite association - COSMIC cancer census association via MalaCards
Search CAT in MalaCards View complete list of genes associated with diseases


  • Acatalasemia (ACATLAS) [MIM:614097]: A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. {ECO:0000269 PubMed:2308162}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for CAT Gene


Relevant External Links for CAT

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CAT: view

Publications for CAT Gene

  1. Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE. (PMID: 18606005) D'souza A. … Scofield R.H. (BMC Med. Genet. 2008) 3 23 48 67
  2. Shear stress stimulates nitric oxide signaling in pulmonary arterial endothelial cells via a reduction in catalase activity: role of protein kinase C delta. (PMID: 19897742) Kumar S. … Black S.M. (Am. J. Physiol. Lung Cell Mol. Physiol. 2010) 3 23
  3. Gene polymorphisms in association with emerging cardiovascular risk markers in adult women. (PMID: 20078877) Fan A.Z. … Mokdad A.H. (BMC Med. Genet. 2010) 3 23
  4. Overexpression of catalase delays G0/G1- to S-phase transition during cell cycle progression in mouse aortic endothelial cells. (PMID: 19341793) Onumah O.E. … Guo Z. (Free Radic. Biol. Med. 2009) 3 23
  5. Catalase activity, serum trace element and heavy metal concentrations, vitamin A, vitamin D and vitamin E levels in hydatidiform mole. (PMID: 19688952) Kolusari A. … Yoruk I.H. (Clin Exp Obstet Gynecol 2009) 3 23

Products for CAT Gene

Sources for CAT Gene

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