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CAT Gene

protein-coding   GIFtS: 73
GCID: GC11P034460

Catalase

  See CAT-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
catalase1 2
EC 1.11.1.63 8

External Ids:    HGNC: 15161   Entrez Gene: 8472   Ensembl: ENSG000001216917   OMIM: 1155005   UniProtKB: P040403   

Export aliases for CAT gene to outside databases

Previous GC identifers: GC11P036013 GC11P035138 GC11P034499 GC11P034424 GC11P034417 GC11P034157


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CAT Gene:
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a
heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen
species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide.
Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as
diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers.
Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is
the only disease known to be caused by this gene. (provided by RefSeq, Oct 2009)

GeneCards Summary for CAT Gene:
CAT (catalase) is a protein-coding gene. Diseases associated with CAT include pityriasis versicolor, and meningitis and encephalitis. GO annotations related to this gene include enzyme binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: CATA_HUMAN, P04040
Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects
of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma
cells, mastocytoma cells and normal and transformed fibroblast cells

Gene Wiki entry for CAT (Catalase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAT gene promoter:
         GR   GR-beta   FOXO1a   GR-alpha   NF-kappaB   NF-kappaB1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAT promoter sequence
   Search Chromatin IP Primers for CAT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

CAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAT gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P034460:  view genomic region     (about GC identifiers)

Start:
34,460,472 bp from pter      End:
34,493,609 bp from pter
Size:
33,138 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CATA_HUMAN, P04040 (See protein sequence)
Recommended Name: Catalase  
Size: 527 amino acids; 59756 Da
Cofactor: Heme group
Cofactor: NADP
Subunit: Homotetramer
6 PDB 3D structures from and Proteopedia for CAT:
1DGB (3D)        1DGF (3D)        1DGG (3D)        1DGH (3D)        1F4J (3D)        1QQW (3D)    
Secondary accessions: A8K6C0 B2RCZ9 D3DR07 Q2M1U4 Q4VXX5 Q9BWT9 Q9UC85

Explore the universe of human proteins at neXtProt for CAT: NX_P04040

Explore proteomics data for CAT at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Ubiquitination2 at Lys243, Lys480
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CAT (P04040) (see all 37)
     DKMLQGR  TVGPRGP  KRNPQTH  KFYTEDG 


    See CAT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001743.1  
    ENSEMBL proteins: 
     ENSP00000241052  
    Reactome Protein details: P04040

    CAT Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for CAT
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    OriGene MassSpec for CAT
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    GenScript Custom Purified and Recombinant Proteins Services for CAT
    Novus Biologicals CAT Proteins
    Novus Biologicals CAT Lysates
    Sino Biological Recombinant Protein for CAT
    Sino Biological Cell Lysate for CAT
    ProSpec Recombinant Protein for CAT
    Cloud-Clone Corp. Proteins for CAT

     
    Search eBioscience for Proteins for CAT 

     
    antibodies-online proteins for CAT (27 products) 

     
    antibodies-online peptides for CAT

    CAT Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CAT (Catalase)
    Cell Signaling Technology (CST) Antibodies for CAT  (catalase)
    OriGene Antibodies for CAT
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    Novus Biologicals CAT Antibodies
    Abcam antibodies for CAT (Q2M1U4, P04040)
    Cloud-Clone Corp. Antibodies for CAT
    ThermoFisher Antibody for CAT
    LSBio Antibodies in human, mouse, rat for CAT
    antibodies-online antibodies for CAT (168 products) 

    CAT Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Proteome Profiler Antibody Arrays for CAT (Catalase)
    GenScript Custom Assay Services for CAT
    Enzo Life Sciences assays for CAT
    Cloud-Clone Corp. ELISAs for CAT
    Cloud-Clone Corp. CLIAs for CAT
    Search eBioscience for ELISAs for CAT 
    antibodies-online kits for CAT (31 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    7 InterPro protein domains (see first 5):
     IPR018028 Catalase
     IPR020835 Catalase-like_dom
     IPR002226 Catalase_haem_BS
     IPR011614 Catalase_core
     IPR010582 Catalase_immune_responsive
     IPR024711 Catalase_clade1/3
     IPR024708 Catalase_AS

    Graphical View of Domain Structure for InterPro Entry P04040

    ProtoNet protein and cluster: P04040

    1 Blocks protein domain: IPB002226 Catalase

    UniProtKB/Swiss-Prot: CATA_HUMAN, P04040
    Similarity: Belongs to the catalase family


    Find genes that share domains with CAT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CATA_HUMAN, P04040
    Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects
    of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma
    cells, mastocytoma cells and normal and transformed fibroblast cells
    Catalytic activity: 2 H(2)O(2) = O(2) + 2 H(2)O

         Genatlas biochemistry entry for CAT:
    catalase,60kDa,peroxisomal,expressed in erythrocytes,liver,kidney,catabolic pathway of activated oxygen
    species,free radical detoxification

         Enzyme Number (IUBMB): EC 1.11.1.61 2

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004046aminoacylase activity IEA--
    GO:0004096catalase activity TAS--
    GO:0005102receptor binding IPI--
    GO:0016209antioxidant activity IDA10514471
    GO:0016684oxidoreductase activity, acting on peroxide as acceptor ISS--
         
    Find genes that share ontologies with CAT           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CAT:
     Increased cell death HMECs cel  Increased cell death in breast 

         4 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cat):
     cellular  homeostasis/metabolism  mortality/aging  tumorigenesis 

    Find genes that share phenotypes with CAT           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cattm1Ysh for CAT

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAT

    miRNA
    Products:
        
    miRTarBase miRNAs that target CAT:
    hsa-mir-30a-5p (MIRT028614), hsa-mir-155-5p (MIRT020866), hsa-mir-30b-5p (MIRT007067), hsa-mir-181b-5p (MIRT047237)

    Block miRNA regulation of human, mouse, rat CAT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAT (see all 9):
    hsa-miR-30c hsa-miR-520d-5p hsa-miR-30d hsa-miR-190b hsa-miR-30a hsa-miR-30b hsa-miR-524-5p hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidCAT 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CAT
    Predesigned siRNA for gene silencing in human, mouse, rat CAT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CAT

    Clone
    Products:
         
    OriGene clones in human, mouse for CAT (see all 7)
    OriGene ORF clones in mouse, rat for CAT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CAT (NM_000019)
    Sino Biological Human cDNA Clone for CAT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAT

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CAT 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CATA_HUMAN, P04040: Peroxisome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    cytosol3
    extracellular3
    mitochondrion3
    nucleus3
    plasma membrane3
    chloroplast2
    cytoskeleton2
    endoplasmic reticulum2
    golgi apparatus2
    lysosome2
    vacuole2
    endosome1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005758mitochondrial intermembrane space IEA--
    GO:0005764lysosome IEA--
    GO:0005777peroxisome IDA18379038
    GO:0005778peroxisomal membrane ISS--

    Find genes that share ontologies with CAT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAT About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Amyotrophic lateral sclerosis (ALS)
    Amyotrophic lateral sclerosis (ALS)0.63
    Amyotrophic lateral sclerosis (ALS)0.63
    2Tryptophan metabolism
    Tryptophan metabolism0.46
    Tryptophan metabolism0.46
    3Detoxification of Reactive Oxygen Species
    Detoxification of Reactive Oxygen Species
    Oxidative Stress Regulatory Pathway (Erythrocyte)0.00
    4Purine metabolism (REACTOME)
    Purine metabolism0.42
    Purine catabolism0.00
    Metabolism of nucleotides0.42
    5Doxorubicin Pathway, Pharmacokinetics
    Doxorubicin Pathway (Cancer Cell), Pharmacodynamics0.43
    Doxorubicin Pathway, Pharmacokinetics0.43


    Find genes that share SuperPaths with CAT           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CAT
        Glucose / Energy Metabolism

    Selected BioSystems Pathways for CAT (see all 9)
        DNA damage response (only ATM dependent)
    Oxidative Stress
    Amyotrophic lateral sclerosis (ALS)
    ethanol degradation IV
    Folate Metabolism


    2 Reactome Pathways for CAT
        Detoxification of Reactive Oxygen Species
    Purine catabolism

    3 PharmGKB Pathways for CAT
        Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics
    Oxidative Stress Regulatory Pathway (Erythrocyte)

    5 Kegg Pathways  (Kegg details for CAT):
        Tryptophan metabolism
    Glyoxylate and dicarboxylate metabolism
    FoxO signaling pathway
    Peroxisome
    Amyotrophic lateral sclerosis (ALS)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CAT (see all 6): 
              Nephrotoxicity in human mouse rat
              Amino Acid Metabolism I in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Cellular Stress Responses in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CAT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CAT (P040402, 3 ENSP000002410524) via UniProtKB, MINT, STRING, and/or I2D (see all 108)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061242, 3, ENSP000003409444MINT-50693 MINT-50695 MINT-50694 I2D: score=4 STRING: ENSP00000340944
    ABL2P426843, ENSP000003565954I2D: score=2 STRING: ENSP00000356595
    EIF2B2P497703, ENSP000002661264I2D: score=2 STRING: ENSP00000266126
    TLR10Q9BXR53, ENSP000003089254I2D: score=2 STRING: ENSP00000308925
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000302response to reactive oxygen species IMP16644728
    GO:0001657ureteric bud development IEA--
    GO:0001666response to hypoxia IEA--
    GO:0001822kidney development IEA--
    GO:0006144purine nucleobase metabolic process TAS--

    Find genes that share ontologies with CAT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAT (CATA)

    Selected HMDB Compounds for CAT (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Hydroxyanthranilic acid2-Amino-3-hydroxybenzoate (see all 17)548-93-6--
    CinnavalininateCinnabarinic acid (see all 4)----
    FormaldehydeAldeide formica (see all 16)50-00-0--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    Manganesemanganese 7439-96-5--
    MethanolAlcool methylique (see all 23)67-56-1--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    OxygenOxygen (see all 5)7782-44-7--
    Superoxidedioxidanidyl (see all 7)11062-77-4--

    2 DrugBank Compounds for CAT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Fomepizole4-methylpyrazole (see all 4)7554-65-6targetinhibitor8423764 3416882 240743
    Heme-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for CAT gene (see all 146)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    superoxide 96.5 4472 2313035 (6), 17240813 (5), 20016428 (5), 7551811 (5) (see all 99)
    h2o2 94.6 1885 9389716 (6), 2066646 (5), 8151246 (5), 7541472 (5) (see all 99)
    oxygen 89.4 716 10628300 (7), 8720898 (4), 11368853 (4), 8082230 (3) (see all 99)
    3-amino-1,2,4-triazole 88.1 229 11829410 (3), 12681527 (3), 1540380 (3), 8264727 (2) (see all 99)
    malondialdehyde 87.7 1211 18778500 (5), 17319275 (5), 17190187 (5), 16112416 (4) (see all 99)
    bathocuproine 87.6 60 1846358 (1), 10547184 (1), 11714440 (1), 12016160 (1) (see all 59)
    ascorbic acid 83.7 611 10525278 (6), 15109571 (6), 17319275 (5), 17190187 (5) (see all 99)
    xanthine 82.1 164 16130269 (3), 16112416 (2), 17571208 (2), 8710749 (2) (see all 99)
    n acetylcysteine 81.8 324 11440976 (4), 9437207 (3), 16984740 (3), 15667587 (3) (see all 99)
    deferoxamine 81.3 167 11316574 (3), 1647676 (3), 1958348 (2), 7672482 (2) (see all 99)

    1 PharmGKB related drug/compound annotation for CAT gene    About this table
    Drug/compound PharmGKB Annotation
    anthracyclines and related substancesCA  



    Find genes that share compounds with CAT           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CAT gene: 
    NM_001752.3  

    Unigene Cluster for CAT:

    Catalase
    Hs.502302  [show with all ESTs]
    Unigene Representative Sequence: NM_001752
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000241052(uc009ykc.1 uc001mvm.3) ENST00000528104 ENST00000530343
    ENST00000525707 ENST00000534710
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CAT (see all 9):
    hsa-miR-30c hsa-miR-520d-5p hsa-miR-30d hsa-miR-190b hsa-miR-30a hsa-miR-30b hsa-miR-524-5p hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidCAT 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CAT
    Clone
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    OriGene ORF clones in mouse, rat for CAT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CAT (NM_000019)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAT
    Primer
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    OriGene qPCR primer pairs and template standards for CAT
    OriGene qSTAR qPCR primer pairs in human, mouse for CAT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAT
      QuantiTect SYBR Green Assays in human, mouse, rat CAT
      QuantiFast Probe-based Assays in human, mouse, rat CAT

    Additional mRNA sequence: 

    AK022134.1 AK291585.1 AK310184.1 AK315350.1 AY028632.1 BC027300.1 BC110398.1 BC112217.1 
    BC112219.1 X04076.1 

    23 DOTS entries:

    DT.219562  DT.100819495  DT.100819489  DT.219561  DT.95261355  DT.97835365  DT.120738830  DT.219557 
    DT.92453028  DT.95261357  DT.100819488  DT.120738832  DT.449665  DT.92406951  DT.100819490  DT.100819491 
    DT.219563  DT.75112267  DT.92453018  DT.95261354  DT.99970908  DT.100738129  DT.97858318 

    Selected AceView cDNA sequences (see all 412):

    CA748580 AI190981 AA329857 BQ016836 BM126827 AA295119 AW514043 CR613834 
    CA394851 AW440886 BG741847 AI986210 CR609505 AL544366 BQ028962 AI064891 
    BG697373 AL546101 CD356537 AW074278 BG740929 BP349459 CA415426 AI263566 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CAT (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c ^ 12 ^
    SP1:                                                                                                  -     -     -                       -                     
    SP2:                                                                                                  -     -     -                       -           -         
    SP3:                                                                                                  -     -     -                       -           -         
    SP4:                          -                 -                                                                                                               
    SP5:                                                                                                  -     -     -                                             

    ExUns: 13a · 13b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CAT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CAT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTAATGTT
    CAT Expression
    About this image


    CAT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
             HyStem+BMP4-induced E15 cells
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Adipose (Muscoskeletal System)
             HyStem+BMP4-induced E15 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+BMP4-induced E15 cells
    CAT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502302
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CAT (see all 6): 
              Nephrotoxicity in human mouse rat
              Amino Acid Metabolism I in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Cellular Stress Responses in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAT gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cat1 , 5 catalase1, 5 85.9(n)1
    89.37(a)1
      2 (54.43 cM)5
    123591  NM_009804.21  NP_033934.21 
     1034538495 
    chicken
    (Gallus gallus)
    Aves CAT1 catalase 81.74(n)
    88.26(a)
      423600  NM_001031215.1  NP_001026386.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    83(a)
    83(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    GL343283.1(1401349-1429216)
    GL343283.1(1515885-1526112)
    African clawed frog
    (Xenopus laevis)
    Amphibia cat-prov2 catalase 77.43(n)    BC054964.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cat2 catalase 77.1(n)   30068  AF170069.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cat1 , 3 catalase reaction catalase3
    Catalase1
    66(a)
    (best of 2)3
    63.39(n)1
    66.73(a)1
      3 75E13
    400481  NM_080483.31  NP_536731.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54G11A.133
    ctl-21
    catalase3
    ctl-21
    62(a)3
    62.46(n)1
    64.15(a)1
      1750851  NM_001027302.51  NP_001022473.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CTA1(YDR256C)4
    CTA11
    Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation less4
    CTA11
    53.18(n)1
    51.15(a)1
      4(969680-968133)4
    8518431, 4  NP_010542.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CAT11 CAT1 53.57(n)
    46.5(a)
      838652  NM_101914.3  NP_564121.1 
    rice
    (Oryza sativa)
    Liliopsida Os.1562 Oryza sativa (japonica cultivar-group) mRNA for catalase, complete cds less 71.62(n)    AK100019.1 


    ENSEMBL Gene Tree for CAT (if available)
    TreeFam Gene Tree for CAT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAT (see all 755)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1175187791,2
    C,F--34387363(+) GTCATT/CACTTG 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1411986761,2
    --34387472(+) AATCCA/CTAGTA 1 -- us2k10--------
    rs2015148591,2
    --34387490(+) AAAGG-/AAAAAA 1 -- us2k10--------
    rs5642501,2
    C,F,A,H--34387523(+) ATGAAC/TAAAGG 1 -- us2k127Minor allele frequency- T:0.20NA NS EA WA CSA 3791
    rs1141243981,2
    C,F--34387533(+) GTTAAG/CAAATG 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1868537961,2
    --34387577(+) GTGTTC/GGTTAG 1 -- us2k10--------
    rs1916404611,2
    --34387979(+) GAAAAG/TTATAG 1 -- us2k10--------
    rs1811203441,2
    --34388036(+) AGTTCC/TACTTT 1 -- us2k10--------
    rs178810291,2
    C,F--34388134(+) TGTACT/CGGAAA 1 -- us2k1 tfbs33Minor allele frequency- C:0.07NS WA 208
    rs92826261,2
    C,F--34388180(+) TGGTAT/CATACT 1 -- us2k111Minor allele frequency- C:0.06MN NS NA WA 722

    HapMap Linkage Disequilibrium report for CAT (34460472 - 34493609 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CAT:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1069n71CNV Gain21882294
    nsv832114CNV Gain17160897
    nsv825835CNV Gain20364138
    dgv1068n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): CAT
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CAT
    DNA2.0 Custom Variant and Variant Library Synthesis for CAT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 115500   
    OMIM disorders: 614097  
    UniProtKB/Swiss-Prot: CATA_HUMAN, P04040
  • Acatalasemia (ACATLAS) [MIM:614097]: A metabolic disorder characterized by a total or near total loss of
    catalase activity in red cells. It is often associated with ulcerating oral lesions. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • Selected diseases for CAT (see all 42):    
    About MalaCards
    pityriasis versicolor    meningitis and encephalitis    acatalasia    spermatic cord torsion
    urogenital tuberculosis    pneumoconiosis    rheumatic heart disease    meningitis
    diabetic cataract    congenital rubella    favism    avascular necrosis of the femoral head
    rubella    neonatal adrenoleukodystrophy    diabetic angiopathy    tetraploidy
    refsum disease    pneumococcal meningitis    vitiligo    bacteremia

    19 diseases from the University of Copenhagen DISEASES database for CAT:
    Vascular disease     Diabetes mellitus     Zellweger syndrome     Toxic encephalopathy
    Cancer     Brain disease     Heart disease     Lung disease
    Neurodegenerative disease     Hyperglycemia     Chronic granulomatous disease     Acatalasia
    Kidney failure     Infantile refsum disease     Vitiligo     Liver disease
    Eye disease     Refsum disease     Spermatic cord torsion

    Find genes that share disorders with CAT           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CAT gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acatalasemia 77.5 12 19122680 (2), 1999334 (2), 11001624 (1), 11197178 (1) (see all 8)
    hypocatalasemia 71.2 1 14996832 (1)
    zellweger syndrome 71.2 10 1946426 (3), 1651504 (1), 9408912 (1), 8931469 (1) (see all 7)
    peroxisomal disorders 68.3 2 2295968 (1), 8463903 (1)
    cell damage 67.2 32 11729237 (2), 19917279 (2), 14675044 (2), 1958348 (1) (see all 27)
    adrenoleukodystrophy neonatal 65 2 7687405 (1), 1689088 (1)
    refsum disease infantile 63.9 6 7510868 (2), 9408912 (1), 1689088 (1), 7687405 (1)
    peroxisome biogenesis disorders 59 4 10567403 (1), 15184617 (1), 10960480 (1)
    granulomatous disease chronic 57.4 7 9864180 (1), 15135177 (1), 1370724 (1), 12706409 (1) (see all 7)
    vitiligo 55.4 66 11837458 (7), 19439879 (4), 18315617 (4), 17433173 (3) (see all 29)

    Genatlas disease: CAT
    acatalasia

    Genetic Association Database (GAD): CAT
    Human Genome Epidemiology (HuGE) Navigator: CAT (269 documents)

    Export disorders for CAT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAT gene, integrated from 10 sources (see all 3584):
    (articles sorted by number of sources associating them with CAT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE. (PubMed id 18606005)1, 4, 9 D'souza A....Scofield R.H. (BMC Med. Genet. 2008)
    2. Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli. (PubMed id 16298864)1, 4, 9 Nadif R....Kauffmann F. (Free Radic. Res. 2005)
    3. Genetic association of the catalase gene (CAT) with vitiligo susceptibility. (PubMed id 11837458)1, 4, 9 Casp C.B....McCormack W.T. (Pigment Cell Res. 2002)
    4. Functional variants in the catalase and myeloperoxidase genes, ambient air pollution, and respiratory-related school absences: an example of epistasis in gene-environment interactions. (PubMed id 19897513)1, 4, 9 Wenten M....Gilliland F.D. (Am. J. Epidemiol. 2009)
    5. Associations between catalase phenotype and genotype: modification by epidemiologic factors. (PubMed id 16775184)1, 4, 9 Ahn J....Ambrosone C.B. (amp 2006)
    6. Polymorphisms in oxidative stress-related genes are not associated with prostate cancer risk in heavy smokers. (PubMed id 17548672)1, 4, 9 Choi J.Y....Ambrosone C.B. (amp 2007)
    7. Association study between catalase gene polymorphisms and the susceptibility to vitiligo in Korean population. (PubMed id 16630078)1, 4, 9 Park H.H....Lee M.H. (Exp. Dermatol. 2006)
    8. Influence of the polymorphism in candidate genes on late cardiac damage in patients treated due to acute leukemia in childhood. (PubMed id 19863340)1, 4, 9 RajiA8 V....Jazbec J. (amp 2009)
    9. [Lack of association between metabolic and antioxidant gene polymorphisms (GSTM1, GSTT1, CAT, MnSOD, GPX1) and maternal quitting of smoking in pregnancy--preliminary results]. (PubMed id 20301895)1, 4, 9 Hozyasz K.K....JagodziA8ski P.P. (Prz. Lek. 2009)
    10. Short arm of chromosome 11 and sporadic Alzheimer's disease: catalase and cathepsin D gene polymorphisms. (PubMed id 18248894)1, 4, 9 Capurso C....Panza F. (Neurosci. Lett. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 847 HGNC: 1516 AceView: CAT Ensembl:ENSG00000121691 euGenes: HUgn847
    ECgene: CAT Kegg: 847 H-InvDB: CAT

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CAT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CAT Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Catalase
    SeattleSNPshttp://pga.gs.washington.edu/data/cat/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAT gene:
    Search GeneIP for patents involving CAT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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