Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CAT Gene

protein-coding GIFtS: 70
GCID: GC11P034460

catalase

Explore 352 diseases affiliated with
CAT via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Catalase¹
EC 1.11.1.6³ ⁸

External Ids:	HGNC: 1516¹	Entrez Gene: 847²	Ensembl: ENSG00000121691⁷	OMIM: 115500⁵	UniProtKB: P04040³

Export aliases for CAT gene to outside databases

Previous GC identifers: GC11P036013 GC11P035138 GC11P034499 GC11P034424 GC11P034417 GC11P034157

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAT:

This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme

enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species

hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress

is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma,

Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have

been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused

by this gene. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: CATA_HUMAN, P04040

Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of

hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells,

mastocytoma cells and normal and transformed fibroblast cells

Gene Wiki entry for CAT (Catalase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CAT gene promoter:
GR GR-beta FOXO1a GR-alpha NF-kappaB NF-kappaB1 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CAT promoter sequence

Search SABiosciences Chromatin IP Primers for CAT

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p13

CAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAT gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P034460: view genomic region (about GC identifiers)

Start:	34,460,472 bp from pter	End:	34,493,609 bp from pter
Size:	33,138 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CATA_HUMAN, P04040 (See protein sequence)

Recommended Name: Catalase

Size: 527 amino acids; 59756 Da

Cofactor: Heme group

Cofactor: NADP

Subunit: Homotetramer

Subcellular location: Peroxisome

6 PDB 3D structures from and Proteopedia for CAT:

1DGB (3D)

1DGF (3D)

1DGG (3D)

1DGH (3D)

1F4J (3D)

1QQW (3D)

Secondary accessions: A8K6C0 B2RCZ9 D3DR07 Q2M1U4 Q4VXX5 Q9BWT9 Q9UC85

Explore the universe of human proteins at neXtProt for CAT: NX_P04040

Post-translational modifications:

The N-terminus is blocked¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P04040

4/37 DME Specific Peptides for CAT (P04040) (see all 37)

DKMLQGR

TVGPRGP

KRNPQTH

KFYTEDG

CAT Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001743.1

ENSEMBL proteins:

ENSP00000241052

Reactome Protein details: P04040
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CAT OriGene Protein Over-expression Lysate: CAT OriGene Custom Protein Services for CAT
	GenScript Custom Purified and Recombinant Proteins Services for CAT
	Novus Biologicals CAT Proteins Novus Biologicals CAT Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CAT
	Uscn Proteins for CAT

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	--	--
GO:0005758	mitochondrial intermembrane space	IEA	--
GO:0005764	lysosome	IEA	--
GO:0005777	peroxisome	IDA	19479899
GO:0005778	peroxisomal membrane	ISS	--

CAT for ontologies About GeneDecksing

CAT Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CAT (Catalase)
	Cell Signaling Technology (CST) Antibodies for CAT (catalase)
	OriGene Antibodies (see all 7): CAT OriGene Custom Antibody Services for CAT
	GenScript Superior Antibodies for CAT
	Novus Biologicals CAT Antibodies
	Abcam antibodies for CAT
	Uscn Antibodies for CAT
	ThermoFisher Antibodies for CAT

Assay Products for CAT:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for CAT (Catalase)
	GenScript Custom Assay Services for CAT
	Enzo Life Sciences assays for CAT
	Uscn ELISAs and CLIAs for CAT

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CAT for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR018028 Catalase

IPR020835 Catalase-like_dom

IPR002226 Catalase_haem_BS

IPR011614 Catalase_core

IPR010582 Catalase_immune_responsive

Graphical View of Domain Structure for InterPro Entry P04040

ProtoNet protein and cluster: P04040

1 Blocks protein family: IPB002226 Catalase

UniProtKB/Swiss-Prot: CATA_HUMAN, P04040

Similarity: Belongs to the catalase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CATA_HUMAN, P04040

Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of

hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells,

mastocytoma cells and normal and transformed fibroblast cells

Catalytic activity: 2 H(2)O(2) = O(2) + 2 H(2)O

Genatlas biochemistry entry for CAT:

catalase,60kDa,peroxisomal,expressed in erythrocytes,liver,kidney,catabolic pathway of activated oxygen species,free

radical detoxification

Enzyme Number (IUBMB): EC 1.11.1.6¹ ²

miRNA Products:		OriGene 3'-UTR Clone: CAT Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAT
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CAT (see all 9):
		hsa-miR-30c hsa-miR-520d-5p hsa-miR-30d hsa-miR-190b hsa-miR-30a hsa-miR-30b hsa-miR-524-5p hsa-miR-30e

		SwitchGear 3'UTR luciferase reporter plasmid: CAT 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAT (see all 7) OriGene shRNA RFP: CAT OriGene siRNA: CAT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAT

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CAT

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAT (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAT OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CAT (NM_000019)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAT
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAT

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CAT
		Search LifeMap BioReagents cell lines for CAT

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAT

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004046	aminoacylase activity	IEA	--
GO:0004096	catalase activity	TAS	--
GO:0005102	receptor binding	IPI	--
GO:0016209	antioxidant activity	IDA	10514471
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	ISS	--

CAT for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CAT:

Increased cell death HMECs cel

Increased cell death in breast

Animal Models:
Mouse knock-out Cat^tm1Ysh for CAT
4 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Cat):

cellular

homeostasis/metabolism

mortality/aging

tumorigenesis

CAT for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Purine metabolism

	Purine metabolism	1.00			Purine catabolism	0.30
	Metabolism of nucleotides	0.42

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Doxorubicin Pathway, Pharmacokinetics

Doxorubicin Pathway, Pharmacokinetics

1.00

Doxorubicin Pathway (Cancer Cell), Pharmacodynamics

0.43

Tryptophan metabolism

Tryptophan metabolism

1.00

Tryptophan metabolism

0.47

Glucose / Energy Metabolism

Glucose / Energy Metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for CAT

Glucose / Energy Metabolism

5/8 BioSystems Pathways for CAT (see all 8)

	DNA damage response (only ATM dependent)
	Selenium Pathway
	Folate Metabolism
	ethanol degradation IV
	Tryptophan metabolism

4 Reactome Pathways for CAT

	Metabolism of nucleotides
	Metabolism
	Purine catabolism
	Purine metabolism

3 PharmGKB Pathways for CAT

	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
	Doxorubicin Pathway, Pharmacokinetics
	Oxidative Stress Regulatory Pathway (Erythrocyte)

4 Kegg Pathways (Kegg details for CAT):

	Tryptophan metabolism
	Metabolic pathways
	Peroxisome
	Amyotrophic lateral sclerosis (ALS)

CAT for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CAT

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/62 Interacting proteins for CAT (P04040^{2, 3} ENSP00000241052⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 62)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN11	Q06124²^,³, ENSP00000340944⁴	MINT-50693 MINT-50695 MINT-50694 I2D: score=4 STRING: ENSP00000340944
KPNB1	Q14974³, ENSP00000290158⁴	I2D: score=5 STRING: ENSP00000290158
ABL2	P42684³, ENSP00000356595⁴	I2D: score=2 STRING: ENSP00000356595
EIF2B2	P49770³, ENSP00000266126⁴	I2D: score=2 STRING: ENSP00000266126
NTMT1	Q9BV86³, ENSP00000361558⁴	I2D: score=2 STRING: ENSP00000361558

About this table

Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000302	response to reactive oxygen species	IMP	16644728
GO:0001666	response to hypoxia	IEA	--
GO:0006144	purine nucleobase metabolic process	TAS	--
GO:0006195	purine nucleotide catabolic process	TAS	--
GO:0006641	triglyceride metabolic process	IEA	--

CAT for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CAT for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CAT

10/11 HMDB Compounds for CAT (see all 11) About this table

Compound	Synonyms	CAS #	PubMed Ids
3-Hydroxyanthranilic acid	2-Amino-3-hydroxybenzoate (see all 17)	548-93-6	--
Cinnavalininate	Cinnabarinic acid (see all 4)	--	--
Formaldehyde	Aldeide formica (see all 16)	50-00-0	--
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
Hydrogen peroxide	Hydrogen peroxide (see all 44)	7722-84-1	--
Manganese	manganese	7439-96-5	--
Methanol	Alcool methylique (see all 23)	67-56-1	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
Oxygen	Oxygen (see all 5)	7782-44-7	--
Superoxide	dioxidanidyl (see all 7)	11062-77-4	--

2 DrugBank Compounds for CAT About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Fomepizole	4-methylpyrazole (see all 4)	7554-65-6	target	inhibitor	8423764 3416882 240743
Heme	--	--	target	--	17139284 17016423 10592235

10/146 Novoseek chemical compound relationships for CAT gene (see all 146) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
superoxide	96.5	4472	2313035 (6), 17240813 (5), 20016428 (5), 7551811 (5) (see all 99)
h2o2	94.6	1885	9389716 (6), 2066646 (5), 8151246 (5), 7541472 (5) (see all 99)
oxygen	89.4	716	10628300 (7), 8720898 (4), 11368853 (4), 8082230 (3) (see all 99)
3-amino-1,2,4-triazole	88.1	229	11829410 (3), 12681527 (3), 1540380 (3), 8264727 (2) (see all 99)
malondialdehyde	87.7	1211	18778500 (5), 17319275 (5), 17190187 (5), 16112416 (4) (see all 99)
bathocuproine	87.6	60	1846358 (1), 10547184 (1), 11714440 (1), 12016160 (1) (see all 59)
ascorbic acid	83.7	611	10525278 (6), 15109571 (6), 17319275 (5), 17190187 (5) (see all 99)
xanthine	82.1	164	16130269 (3), 16112416 (2), 17571208 (2), 8710749 (2) (see all 99)
n acetylcysteine	81.8	324	11440976 (4), 9437207 (3), 16984740 (3), 15667587 (3) (see all 99)
deferoxamine	81.3	167	11316574 (3), 1647676 (3), 1958348 (2), 7672482 (2) (see all 99)

1 PharmGKB related drug/compound annotation for CAT gene

Drug/compound	PharmGKB Annotation
anthracyclines and related substances	CA

About this table

Search CenterWatch for drugs/clinical trials and news about CAT / CATA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CAT gene:

NM_001752.3

Unigene Cluster for CAT:

Catalase

Hs.502302 [show with all ESTs]

Unigene Representative Sequence: NM_001752

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000241052(uc009ykc.1 uc001mvm.3) ENST00000528104 ENST00000530343

ENST00000525707 ENST00000534710

miRNA Products:		OriGene 3'-UTR Clone: CAT Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAT
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CAT (see all 9):
		hsa-miR-30c hsa-miR-520d-5p hsa-miR-30d hsa-miR-190b hsa-miR-30a hsa-miR-30b hsa-miR-524-5p hsa-miR-30e

		SwitchGear 3'UTR luciferase reporter plasmid: CAT 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAT (see all 7) OriGene shRNA RFP: CAT OriGene siRNA: CAT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAT

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAT (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAT OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CAT (NM_000019)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAT
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAT

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAT Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CAT
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAT
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAT

Additional cDNA sequence:

AK022134.1 AK291585.1 AK310184.1 AK315350.1 AY028632.1 BC027300.1 BC110398.1 BC112217.1

BC112219.1 X04076.1

23 DOTS entries:

DT.219562 DT.100819495 DT.95261355 DT.100819489 DT.219561 DT.92453028 DT.97835365 DT.120738830

DT.219557 DT.95261357 DT.100819488 DT.100819491 DT.120738832 DT.449665 DT.92406951 DT.100819490

DT.219563 DT.75112267 DT.92453018 DT.95261354 DT.99970908 DT.100738129 DT.97858318

412 AceView cDNA sequences (see top 24):

AW768666 AA864685 AW440886 AW069129 N77183 BM126827 BG741847 AW514043

BU682877 BQ229200 BQ016836 BQ948440 AL545053 AA379512 BM559223 CR591917

AI190981 BG740929 AI986210 AW955654 BF593978 AI753159 CB162046 BE045822

AI754846 W94164 BU686348 BM992655 AI241022 BU159578 AL531215 CR597192

AA931316 AW074278 AA295119 BM127432 AA235275 CB265684 AL544366 AI064891

H08508 BM973925 AL522103 BP349459 CD356537 AL546101 BQ223611 AI110765

AA310030 BC027300 CA748580 CA415426 N53692 BQ028962 AW468328 H44348

BQ576174 AW151306 NM_001752 AA234813 CR613834 AA281208 BU176925 BE934862

AF074672 BG697373 CA448073 CB217025 CR602251 CR609505 AA329857 CA308335

BE887595 AA307773 R29244 AI263566 AA448865 CA394851 CR595503 BG618675

BM126574 AL557873 AI472544 BM790120 CK906111 BU170777 W89002 AA376027

T28273 BG504432 BG257355 BM993439 AL544983 AA938252 BX439189 N54600

BU507219 BG290973 CD677959 N95161 BM994647 AA845445 AA863178 BM127162

CB157408 CB163876 AL571584 N52816 AI015491 BM148233 BG911295 BQ446814

AI076597 CD612790 AA469091 N54994 AY028632 BM127193 CF553069 AI762733

BE350728 AA632280 AA772470 CK906110 BG533874 BM554521 AA975812 BX111485

BF213488 AI422533 W38320 AI570083 AI817101 AA907677 BU660615 BX405847

W21075 H80541 AL579826 BM478712 BG430155 AW023382 BV203962 BX443838

BX374486 N58415 AW408313 BQ214638 BM263491 BQ921183 BG291733 BG433252

BM127476 BX507279 BG527718 BX420018 BI224258 CB984669 AL570517 BG474732

CD000764 CB987249 R29628 BG494908 BG779290 AU279426 AV685012 BG876359

CB156895 BG391050 AL547437 BM887895 AL568950 AI075171 BM543150 X04076

BG287806 AL552079 BG616480 AA306671 BG720352 AA977518 AJ706040 BQ901004

BQ225566 BM045188 CB850712 BM803523 CD520461 AA386095 AU137732 BM557925

AA023033 AL550854 BG676753 AW467281 AL570990 AL560347 BM682151 AI085860

D57889 AA129112 BU663682 BG618601 AI027380 N78004 BE910457 AA034002

AW001508 BF977199 AV698996 H44347 BG428835 AA687179 AI130826 AL570940

BF977781 BI915666 N72315 D57310 BU664876 BF109334 AA447929 BE278234

AL531214 BE245569 AV698077 AI660972 AA283011 BG719377 CN483512 BM263803

BE168808 BI334263 R95779 BM149856 AA375781 AW236649 AA347447 AL531624

H57887 AV693165 H57888 AI951242 AL528438 AA742547 BM194287 AA333522

T89165 AV692042 H91412 D58109 BG674965 H08784 BM146816 AV683660

AA379525 AW377641 BQ354479 BI094296 AV685904 R58521 AV696669 BG494301

R95829 D57067 BQ021433 BG567724 AA627853 AV689362 BG434208 AV683717

AL575484 N76681 AI361532 AA033902 AV685010 BF106327 CD612788 H10490

AL541530 D57405 BF215206 H69105 AV685776 N68549 AW377644 BG777700

AA093637 AV685100 AA283098 BF832384 BG431050 AV744402 AV742004 BE165423

AW080333 BG565211 R01947 H80415 BF577018 CF552531 AV741976 D58293

H65828 N73055 BE882344 AW073972 BG616492 AA127891 H74095 AV760639

H80416 AV741291 H73903 BI551632 AV758200 H15685 BU928850 AA022516

AI924868 AL549785 BQ328467 BG618565 BU860612 N93938 R43318 BM464151

AA814369 AL564118 BQ371617 BM152538 AL572480 AV740967 AW389573 AL523583

AL528472 D56878 BU933273 BF184422 AA910878 AV736978 AL581811 AV685101

R97494 T85207 AW389551 AW574839 AI865940 AI580051 W40438 BF695917

AV743714 BE387495 N64432 T90919 BG426038 H80597 AV743717 AA379242

BF839150 BF240689 BF674875 BM148947 BQ328468 AL550981 BE881891 AA089568

AW966856 H15684 H21664 BF848223 H47388 T59052 H09732 BG877090

AV698898 AV736223 BF218273 T59128 AV740714 CD612791 BE241739 AV682165

H73408 D56632 BF950760 R94648 H48302 AL522102 BQ889870 BE166089

BF575300 AV738752 BI549943 R97623 CD299108 BG178989 AV744729 AV742562

AV743913 AA129111 T84667 BU564744 R33325 H57212 N58658 BG618372

R33326 R20226 T88783 AV706857

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CAT (see all 12) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	·	9d	^	10	^	11a	·	11b	·	11c	^	12	^
SP1:																																	-		-		-								-
SP2:																																	-		-		-								-				-
SP3:																																	-		-		-								-				-
SP4:									-						-
SP5:																																	-		-		-

ExUns:	13a	·	13b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CAT

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CAT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTTAATGTT

About this image

CAT expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

HyStem+BMP4-induced E15 cells (HyStem+BMP4 inductio...)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CAT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CAT

SOURCE GeneReport for Unigene cluster: Hs.502302

SABiosciences Expression via Pathway-Focused PCR Arrays including CAT (see all 6):

Nephrotoxicity in human mouse rat

Amino Acid Metabolism I in human mouse rat

Oxidative Stress in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Cellular Stress Responses in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAT Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CAT
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAT
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAT

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for CAT gene from 11/40 species (see all 40) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cat^{1 , 5}	catalase^{1, 5}	85.9(n)¹ 89.37(a)¹		2 (54.43 cM)⁵ 12359¹ NM_009804.2¹ NP_033934.2¹ 103453849⁵
chicken (Gallus gallus)	Aves	CAT¹	catalase	81.74(n) 88.26(a)		423600 NM_001031215.1 NP_001026386.1
lizard (Anolis carolinensis)	Reptilia	CAT⁶ --	--	83(a) 82(a)	many → 1 many → 1	GL343283.1(1401544-1429216) GL343283.1(1515885-1526112)
African clawed frog (Xenopus laevis)	Amphibia	cat-prov²	catalase	77.43(n)		BC054964.1
zebrafish (Danio rerio)	Actinopterygii	cat²	catalase	77.1(n)		30068 AF170069.1
fruit fly (Drosophila melanogaster)	Insecta	Cat^{1 , 3}	catalase reaction catalase³ Catalase¹	66(a) (best of 2)³ 63.39(n)¹ 66.73(a)¹		3 75E1³ 40048¹ NM_080483.2¹ NP_536731.1¹
worm (Caenorhabditis elegans)	Secernentea	Y54G11A.13³ ctl-2¹	catalase³ Protein CTL-2¹	62(a)³ 62.53(n)¹ 64.15(a)¹		175085¹ NM_001027302.4¹ NP_001022473.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CTA1(YDR256C)⁴ CTA1¹	Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation less⁴ Cta1p¹	53.25(n)¹ 51.15(a)¹		4(969680-968133)⁴ 851843^{1, 4} NP_010542.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	CAT1¹	catalase 1	55.96(n) 50.78(a)		838652 NM_101914.3 NP_564121.1
rice (Oryza sativa)	Liliopsida	Os.156²	Oryza sativa (japonica cultivar-group) mRNA for catalase, complete cds less	71.62(n)		AK100019.1

ENSEMBL Gene Tree for CAT (if available)
TreeFam Gene Tree for CAT (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17881029^1,2	C,F,	--	34156828(+)	`TGTACT/CGGAAA`	1	--	us2k¹ tfbs³		3		NS WA	208
rs9282626^1,2	C,F,	--	34156874(+)	`TGGTAT/CATACT`	1	--	us2k¹		11		MN NS NA WA	722
rs9282627^1,2	C,F,	--	34157047(+)	`CAAAGC/TTTTTC`	1	--	us2k¹		8		MN NS WA	604
rs17883920^1,2	C,F,	--	34157384(+)	`CGTATG/AGCAAA`	1	--	us2k¹		5		NS NA WA	208
rs17887248^1,2	C	--	34158195(+)	`GCTTTG/TTTGTC`	1	--	int¹		4		NS NA	96
rs17882039^1,2	C,	--	34158218(+)	`GGGTGG/ATTGCT`	1	--	int¹		4		NS NA	96
rs75096421^1,2		--	34158766(+)	`GTTATC/TTGTAG`	1	--	int¹		0	--	--	--	--
rs17883367^1,2	C,	--	34158880(+)	`CTGGCC/TTGTGC`	1	--	int¹		3		NS EA	202
rs7126610^1,2	C,F,H,	--	34158979(+)	`CCCAGG/CGAGTC`	1	--	int¹		13		NA NS EA WA	884
rs12272630^1,2	C,F,H,	--	34159021(+)	`TTAATG/CGTAGA`	1	--	int¹		16		NS EA NA WA CSA	900

HapMap Linkage Disequilibrium report for CAT (34460472 - 34493609 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CAT: --
Human Gene Mutation Database (HGMD): CAT

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAT

DNA2.0 Custom Variant and Variant Library Synthesis for CAT

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CAT for disorders About GeneDecksing

OMIM gene information: 115500 OMIM disorders: --

UniProtKB/Swiss-Prot: CATA_HUMAN, P04040

Defects in CAT are the cause of acatalasemia (ACATLAS) [MIM:614097]. A metabolic disorder characterized by

absence of catalase activity in red cells and is often associated with ulcerating oral lesions

20/352 diseases for CAT (see all 352): About MalaCards

systemic lupus erythematosus lupus erythematosus rheumatoid arthritis peroxisomal biogenesis disorder

peroxisome biogenesis disorders post-traumatic stress disorder pityriasis versicolor maple syrup urine disease

pthirus pubis infestation werdnig-hoffmann disease estrogen-receptor negative breast cancer alzheimer's disease

chondrodysplasia punctata glycogen storage disease type ia spermatic cord torsion rhizomelic chondrodysplasia punctata

avascular necrosis of femoral head obsessive-compulsive disorder hermansky-pudlak syndrome mitral valve prolapse

10/92 Novoseek disease relationships for CAT gene (see all 92) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
acatalasemia	77.5	12	19122680 (2), 1999334 (2), 11001624 (1), 11197178 (1) (see all 8)
hypocatalasemia	71.2	1	14996832 (1)
zellweger syndrome	71.2	10	1946426 (3), 1651504 (1), 9408912 (1), 8931469 (1) (see all 7)
peroxisomal disorders	68.3	2	2295968 (1), 8463903 (1)
cell damage	67.2	32	11729237 (2), 19917279 (2), 14675044 (2), 1958348 (1) (see all 27)
adrenoleukodystrophy neonatal	65	2	7687405 (1), 1689088 (1)
refsum disease infantile	63.9	6	7510868 (2), 9408912 (1), 1689088 (1), 7687405 (1)
peroxisome biogenesis disorders	59	4	10567403 (1), 15184617 (1), 10960480 (1)
granulomatous disease chronic	57.4	7	9864180 (1), 15135177 (1), 1370724 (1), 12706409 (1) (see all 7)
vitiligo	55.4	66	11837458 (7), 19439879 (4), 18315617 (4), 17433173 (3) (see all 29)

Genatlas disease: CAT

acatalasia

Genetic Association Database (GAD): CAT
Human Genome Epidemiology (HuGE) Navigator: CAT (269 documents)

Export disorders for CAT gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CAT gene, integrated from 9 sources (see all 3563):
(articles sorted by number of sources associating them with CAT)

Utopia: connect your pdf to the dynamic
world of online information

Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli. (PubMed id 16298864)^{1, 4, 9} Nadif R....Kauffmann F. (2005)
Genetic association of the catalase gene (CAT) with vitiligo susceptibility. (PubMed id 11837458)^{1, 4, 9} Casp C.B....McCormack W.T. (2002)
Genetic polymorphisms of oxidative and antioxidant enzymes and arsenic-related hypertension. (PubMed id 16076760)^{1, 4, 9} Hsueh Y.M....Chen C.J. (2005)
[Associative analysis of the connection between mutation C1167T in the catalase gene and polymorphic marker D6S392 nearby the Mn-dependent superoxide dismutase gene with diabetic microangiopathies] (PubMed id 12469627)^{1, 4, 9} Chistiakov D.A....Debabov V.G. (2002)
Vulnerability of the human airway epithelium to hyperoxia. Constitutive expression of the catalase gene in human bronchial epithelial cells despite oxidant stress. (PubMed id 8282800)^{1, 2, 9} Yoo J.-H.... Crystal R.G. (1994)
A testing framework for identifying susceptibility genes in the presence of epistasis. (PubMed id 16385446)^{1, 4, 9} Millstein J....Gauderman W.J. (2006)
Genetic polymorphisms of GSTT1, GSTM1, GSTP1, MnSOD, and catalase in nonhereditary chronic pancreatitis: evidence of xenobiotic stress and impaired antioxidant capacity. (PubMed id 16047490)^{1, 4, 9} Rahman S.H....McMahon M.J. (2005)
Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer. (PubMed id 15705913)^{1, 4, 9} Ambrosone C.B....Trovato A. (2005)
[Search for the association of polymorphic markers for genes coding for antioxidant defense enzymes, with development of diabetic polyneuropathies in patients with type 1 diabetes mellitus] (PubMed id 15125229)^{1, 4, 9} Zotova E.V....Nosikov V.V. (2004)
Association of antioxidant enzyme gene polymorphisms and glutathione status with severe acute pancreatitis. (PubMed id 15131792)^{1, 4, 9} Rahman S.H....McMahon M.J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 847	HGNC: 1516	AceView: CAT	Ensembl:ENSG00000121691	euGenes: HUgn847
ECgene: CAT	Kegg: 847	H-InvDB: CAT

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CAT	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CAT	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Catalase
SeattleSNPs	http://pga.gs.washington.edu/data/cat/

Intellectual Property for CAT gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CAT gene:
Search GeneIP for patents involving CAT

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for CAT (Catalase)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for CAT (Catalase)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for CAT		OriGene shRNA RFP for CAT
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAT		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAT
	OriGene Protein Over-expression Lysate for CAT		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CAT		OriGene 3'-UTR Clone for CAT
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAT		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAT
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for CAT		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CAT		OriGene Custom Protein Services for CAT
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CAT
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAT
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAT
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAT
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAT
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAT

	GenScript Custom Purified and Recombinant Proteins Services for CAT		GenScript cDNA clones with any tag delivered in your preferred vector for CAT
	GenScript Custom Assay Services for CAT		GenScript Superior Antibodies for CAT
	GenScript Custom overexpressing Cell Line Services for CAT		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for CAT (catalase)

	Regulatory tfbs in CAT promoter
	Search Chromatin IP Primers for CAT
	RT² qPCR Primer Assay in human, mouse, rat CAT
	GNC Network for CAT
	SABiosciences PCR Arrays including human, mouse, rat CAT

Search Tocris compounds for CAT

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Assays for CAT
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CAT antibodies
	CAT proteins
	CAT lysates

	Antibodies for CAT
	See all of Abcam's Antibodies, Kits and Proteins for CAT
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for CAT

CAT Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CAT

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAT

	SwitchGear 3'UTR luciferase reporter plasmids for CAT
	SwitchGear Promoter luciferase reporter plasmids for CAT

ThermoFisher Antibodies for CAT

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAT

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CAT gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

CAT Gene

catalase

Aliases
for CAT gene

Summaries
for CAT gene

Genomic Views
for CAT gene

Proteins
for CAT gene

Protein Domains /
Families
for CAT gene

Function
for CAT gene

Pathways & Interactions
for CAT gene

Drugs & Compounds
for CAT gene

Transcripts
for CAT gene

Expression
for CAT gene

Orthologs
for CAT gene

Paralogs
for CAT gene

Genomic Variants
for CAT gene

Disorders / Diseases
for CAT gene

Publications
for CAT gene

External Searches for CAT gene

Genome Databases showing CAT gene

Other Databases showing CAT gene

Specialized Databases showing CAT gene

Intellectual Property
for CAT gene

Products
for CAT gene

View Random Gene

Senile cataract
WILSON DISEASE
Infertility
Genetic Susceptibility
Osteomyelitis
Acute myocardial infarction
Refsum Disease Infantile
Peroxisomal Disorders
Xeroderma Pigmentosum
Polyps
ADENOCARCINOMA LUNG
Protoporphyria Erythropoietic
OXIDASE DEFICIENCY
Atherosclerosis
Ischemia
Asphyxia
Skin Diseases
Intoxication
Esophagitis
cell damage
Cancer
Hemolysis
Meningitis
Hepatitis B Chronic
RENAL DISEASE
Granulomatous Disease Chronic
Shock
Alcoholic Cirrhosis
Adrenoleukodystrophy Neonatal
Inflammation
Diabetic Nephropathies
Pityriasis Versicolor
Oral Cancer
Hepatitis
immunodeficiency
Hyperglycemia
LIVER DAMAGE
Tumors
Hypocatalasemia
Cardiovascular Diseases
Refsum Disease
Necrosis
Renal Failure Acute
Hepatoblastoma
Preeclampsia
Adrenoleukodystrophy
trichothiodystrophy
Acatalasemia
Zellweger Syndrome
Neurodegenerative Diseases
Melanoma
Tuberculosis Pulmonary
promyelocytic leukemia
Parkinson Disease
Glioma
atherosclerotic plaque
Superficial gastritis
Diabetic Angiopathies
INFARCT
Leukemia
Alzheimers Disease
Bacteremia
MPO DEFICIENCY
Diabetes Mellitus
Osteosarcoma
neurodegeneration
Cataract
PEROXISOME BIOGENESIS DISORDERS
CERVICAL CARCINOMA
Lymphopenia
Goiter
CHRONIC RHEUMATIC HEART DISEASE
Pneumoconiosis
Skin Cancer
Respiratory disease
Liver Diseases Alcoholic
Diabetic cataract
Chondrodysplasia Punctata Rhizomelic
Gastritis
Lung diseases
Infertility Male
Atrophy
Vascular Diseases
Iron Overload
Granuloma
clastogenesis
Glomerulonephritis
NIDDM
Growth retardation
Vitiligo
Encephalitis
Renal Failure Chronic

Advanced Search

Export list of displayed genes

CAT Gene

catalase

Aliasesfor CAT gene

Summariesfor CAT gene

Genomic Viewsfor CAT gene

Proteinsfor CAT gene

Protein Domains /Familiesfor CAT gene

Functionfor CAT gene

Pathways & Interactionsfor CAT gene

Drugs & Compoundsfor CAT gene

Transcriptsfor CAT gene

Expression for CAT gene

Orthologsfor CAT gene

Paralogsfor CAT gene

Genomic Variantsfor CAT gene

Disorders / Diseasesfor CAT gene

Publicationsfor CAT gene

External Searches for CAT gene

Genome Databases showing CAT gene

Other Databases showing CAT gene

Specialized Databases showing CAT gene

Intellectual Propertyfor CAT gene

Productsfor CAT gene

View Random Gene

Aliases
for CAT gene

Summaries
for CAT gene

Genomic Views
for CAT gene

Proteins
for CAT gene

Protein Domains /
Families
for CAT gene

Function
for CAT gene

Pathways & Interactions
for CAT gene

Drugs & Compounds
for CAT gene

Transcripts
for CAT gene

Expression
for CAT gene

Orthologs
for CAT gene

Paralogs
for CAT gene

Genomic Variants
for CAT gene

Disorders / Diseases
for CAT gene

Publications
for CAT gene

Intellectual Property
for CAT gene

Products
for CAT gene