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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CAT Gene

protein-coding GIFtS: 73
GCID: GC11P034460

Catalase

Microbiology & Infectious Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
catalase¹ ²
EC 1.11.1.6³ ⁸

External Ids:	HGNC: 1516¹	Entrez Gene: 847²	Ensembl: ENSG00000121691⁷	OMIM: 115500⁵	UniProtKB: P04040³

Export aliases for CAT gene to outside databases

Previous GC identifers: GC11P036013 GC11P035138 GC11P034499 GC11P034424 GC11P034417 GC11P034157

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAT Gene:

This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a

heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen

species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide.

Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as

diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers.

Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is

the only disease known to be caused by this gene. (provided by RefSeq, Oct 2009)

GeneCards Summary for CAT Gene:

CAT (catalase) is a protein-coding gene. Diseases associated with CAT include pityriasis versicolor, and urogenital tuberculosis, and among its related super-pathways are Tryptophan metabolism and Metabolism of nucleotides. GO annotations related to this gene include enzyme binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: CATA_HUMAN, P04040

Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects

of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma

cells, mastocytoma cells and normal and transformed fibroblast cells

Gene Wiki entry for CAT (Catalase) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.2 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CAT gene promoter:
GR GR-beta FOXO1a GR-alpha NF-kappaB NF-kappaB1 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CAT promoter sequence

Search SABiosciences Chromatin IP Primers for CAT

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p13

CAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAT gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P034460: view genomic region (about GC identifiers)

Start:	34,460,472 bp from pter	End:	34,493,609 bp from pter
Size:	33,138 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CATA_HUMAN, P04040 (See protein sequence)

Recommended Name: Catalase

Size: 527 amino acids; 59756 Da

Cofactor: Heme group

Cofactor: NADP

Subunit: Homotetramer

Subcellular location: Peroxisome

6 PDB 3D structures from and Proteopedia for CAT:

1DGB (3D)

1DGF (3D)

1DGG (3D)

1DGH (3D)

1F4J (3D)

1QQW (3D)

Secondary accessions: A8K6C0 B2RCZ9 D3DR07 Q2M1U4 Q4VXX5 Q9BWT9 Q9UC85

Explore the universe of human proteins at neXtProt for CAT: NX_P04040

Explore proteomics data for CAT at MOPED

Post-translational modifications:

UniProtKB: The N-terminus is blocked

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P04040

4/37 DME Specific Peptides for CAT (P04040) (see all 37)

DKMLQGR

TVGPRGP

KRNPQTH

KFYTEDG

CAT Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_001743.1

ENSEMBL proteins:

ENSP00000241052

Reactome Protein details: P04040
Human Recombinant Protein Products for CAT:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals CAT Proteins Novus Biologicals CAT Lysates
	Sino Biological Recombinant Protein for CAT Sino Biological Cell Lysate for CAT
	ProSpec Recombinant Protein for CAT
	Cloud-Clone Corp. Proteins for CAT

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	--	--
GO:0005758	mitochondrial intermembrane space	IEA	--
GO:0005764	lysosome	IEA	--
GO:0005777	peroxisome	IDA	18379038
GO:0005778	peroxisomal membrane	ISS	--

CAT for ontologies About GeneDecksing

CAT Antibody Products:

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Assay Products for CAT:

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	Enzo Life Sciences assays for CAT
	Cloud-Clone Corp. ELISAs for CAT Cloud-Clone Corp. CLIAs for CAT

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5/7 InterPro protein domains (see all 7):

IPR018028 Catalase

IPR020835 Catalase-like_dom

IPR002226 Catalase_haem_BS

IPR011614 Catalase_core

IPR010582 Catalase_immune_responsive

Graphical View of Domain Structure for InterPro Entry P04040

ProtoNet protein and cluster: P04040

1 Blocks protein domain: IPB002226 Catalase

UniProtKB/Swiss-Prot: CATA_HUMAN, P04040

Similarity: Belongs to the catalase family

CAT for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CATA_HUMAN, P04040

Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects

of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma

cells, mastocytoma cells and normal and transformed fibroblast cells

Catalytic activity: 2 H(2)O(2) = O(2) + 2 H(2)O

Genatlas biochemistry entry for CAT:

catalase,60kDa,peroxisomal,expressed in erythrocytes,liver,kidney,catabolic pathway of activated oxygen

species,free radical detoxification

Enzyme Number (IUBMB): EC 1.11.1.6¹ ²

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004046	aminoacylase activity	IEA	--
GO:0004096	catalase activity	TAS	--
GO:0005102	receptor binding	IPI	--
GO:0016209	antioxidant activity	IDA	10514471
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	ISS	--

CAT for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for CAT:

Increased cell death HMECs cel

Increased cell death in breast

4 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Cat):

cellular

homeostasis/metabolism

mortality/aging

tumorigenesis

CAT for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Cat^tm1Ysh for CAT

inGenious Targeting Laboratory - Custom generated mouse model solutions for CAT

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAT

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAT

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAT

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAT
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CAT (see all 9):
		hsa-miR-30c hsa-miR-520d-5p hsa-miR-30d hsa-miR-190b hsa-miR-30a hsa-miR-30b hsa-miR-524-5p hsa-miR-30e

		SwitchGear 3'UTR luciferase reporter plasmid: CAT 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: CAT (NM_000019)
		Sino Biological Human cDNA Clone for CAT
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		Sirion Biotech Customized lentivirus for stable overexpression of CAT Customized lentivirus expression plasmids for stable overexpression of CAT

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CAT
		Search LifeMap BioReagents cell lines for CAT

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAT

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CAT About (see all 16)

See pathways by source

SuperPath

Contained pathways About

Tryptophan metabolism

Tryptophan metabolism

0.46

Tryptophan metabolism

0.46

Purine metabolism

	Purine metabolism	0.42			Purine catabolism	0.30
	Metabolism of nucleotides	0.42

Doxorubicin Pathway, Pharmacokinetics

Doxorubicin Pathway (Cancer Cell), Pharmacodynamics

0.43

Doxorubicin Pathway, Pharmacokinetics

0.43

ethanol degradation II

ethanol degradation IV

0.57

Metabolism

Metabolism

0.40

Pathways by source See SuperPaths
Show all pathways

1 Cell Signaling Technology (CST) Pathway for CAT

Glucose / Energy Metabolism

5/8 BioSystems Pathways for CAT (see all 8)

	DNA damage response (only ATM dependent)
	Oxidative Stress
	ethanol degradation IV
	Selenium Pathway
	Folate Metabolism

4 Reactome Pathways for CAT

	Metabolism of nucleotides
	Metabolism
	Purine catabolism
	Purine metabolism

3 PharmGKB Pathways for CAT

	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
	Doxorubicin Pathway, Pharmacokinetics
	Oxidative Stress Regulatory Pathway (Erythrocyte)

4 Kegg Pathways (Kegg details for CAT):

	Tryptophan metabolism
	Glyoxylate and dicarboxylate metabolism
	Peroxisome
	Amyotrophic lateral sclerosis (ALS)

CAT for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CAT

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/62 Interacting proteins for CAT (P04040^{2, 3} ENSP00000241052⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 62)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN11	Q06124²^,³, ENSP00000340944⁴	MINT-50693 MINT-50695 MINT-50694 I2D: score=4 STRING: ENSP00000340944
KPNB1	Q14974³, ENSP00000290158⁴	I2D: score=5 STRING: ENSP00000290158
ABL2	P42684³, ENSP00000356595⁴	I2D: score=2 STRING: ENSP00000356595
EIF2B2	P49770³, ENSP00000266126⁴	I2D: score=2 STRING: ENSP00000266126
NTMT1	Q9BV86³, ENSP00000361558⁴	I2D: score=2 STRING: ENSP00000361558

About this table

Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000302	response to reactive oxygen species	IMP	16644728
GO:0001666	response to hypoxia	IEA	--
GO:0006144	purine nucleobase metabolic process	TAS	--
GO:0006195	purine nucleotide catabolic process	TAS	--
GO:0006641	triglyceride metabolic process	IEA	--

CAT for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CAT for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CAT (CATA)

10/11 HMDB Compounds for CAT (see all 11) About this table

Compound	Synonyms	CAS #	PubMed Ids
3-Hydroxyanthranilic acid	2-Amino-3-hydroxybenzoate (see all 17)	548-93-6	--
Cinnavalininate	Cinnabarinic acid (see all 4)	--	--
Formaldehyde	Aldeide formica (see all 16)	50-00-0	--
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
Hydrogen peroxide	Hydrogen peroxide (see all 44)	7722-84-1	--
Manganese	manganese	7439-96-5	--
Methanol	Alcool methylique (see all 23)	67-56-1	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
Oxygen	Oxygen (see all 5)	7782-44-7	--
Superoxide	dioxidanidyl (see all 7)	11062-77-4	--

2 DrugBank Compounds for CAT About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Fomepizole	4-methylpyrazole (see all 4)	7554-65-6	target	inhibitor	8423764 3416882 240743
Heme	--	--	target	--	17139284 17016423 10592235

10/146 Novoseek inferred chemical compound relationships for CAT gene (see all 146) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
superoxide	96.5	4472	2313035 (6), 17240813 (5), 20016428 (5), 7551811 (5) (see all 99)
h2o2	94.6	1885	9389716 (6), 2066646 (5), 8151246 (5), 7541472 (5) (see all 99)
oxygen	89.4	716	10628300 (7), 8720898 (4), 11368853 (4), 8082230 (3) (see all 99)
3-amino-1,2,4-triazole	88.1	229	11829410 (3), 12681527 (3), 1540380 (3), 8264727 (2) (see all 99)
malondialdehyde	87.7	1211	18778500 (5), 17319275 (5), 17190187 (5), 16112416 (4) (see all 99)
bathocuproine	87.6	60	1846358 (1), 10547184 (1), 11714440 (1), 12016160 (1) (see all 59)
ascorbic acid	83.7	611	10525278 (6), 15109571 (6), 17319275 (5), 17190187 (5) (see all 99)
xanthine	82.1	164	16130269 (3), 16112416 (2), 17571208 (2), 8710749 (2) (see all 99)
n acetylcysteine	81.8	324	11440976 (4), 9437207 (3), 16984740 (3), 15667587 (3) (see all 99)
deferoxamine	81.3	167	11316574 (3), 1647676 (3), 1958348 (2), 7672482 (2) (see all 99)

1 PharmGKB related drug/compound annotation for CAT gene About this table

Drug/compound	PharmGKB Annotation
anthracyclines and related substances	CA

Search CenterWatch for drugs/clinical trials and news about CAT / CATA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CAT gene:

NM_001752.3

Unigene Cluster for CAT:

Catalase

Hs.502302 [show with all ESTs]

Unigene Representative Sequence: NM_001752

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000241052(uc009ykc.1 uc001mvm.3) ENST00000528104 ENST00000530343

ENST00000525707 ENST00000534710

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAT
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CAT (see all 9):
		hsa-miR-30c hsa-miR-520d-5p hsa-miR-30d hsa-miR-190b hsa-miR-30a hsa-miR-30b hsa-miR-524-5p hsa-miR-30e

		SwitchGear 3'UTR luciferase reporter plasmid: CAT 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: CAT (NM_000019)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAT

Additional mRNA sequence:

AK022134.1 AK291585.1 AK310184.1 AK315350.1 AY028632.1 BC027300.1 BC110398.1 BC112217.1

BC112219.1 X04076.1

23 DOTS entries:

DT.219562 DT.100819495 DT.100819489 DT.219561 DT.95261355 DT.97835365 DT.120738830 DT.219557

DT.92453028 DT.95261357 DT.100819488 DT.120738832 DT.449665 DT.92406951 DT.100819490 DT.100819491

DT.219563 DT.75112267 DT.92453018 DT.95261354 DT.99970908 DT.100738129 DT.97858318

24/412 AceView cDNA sequences (see all 412):

AI064891 BM973925 AI241022 AL544366 BQ223611 AI263566 CB162046 CR602251

H08508 N77183 BC027300 BG697373 AW151306 CB217025 BP349459 AA931316

BF593978 AW074278 AA234813 BM559223 AA448865 BU686348 AA295119 W94164

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CAT (see all 12) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	·	9d	^	10	^	11a	·	11b	·	11c	^	12	^
SP1:																																	-		-		-								-
SP2:																																	-		-		-								-				-
SP3:																																	-		-		-								-				-
SP4:									-						-
SP5:																																	-		-		-

ExUns:	13a	·	13b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CAT

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CAT expression in normal human tissues (normalized intensities) CAT embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCTTAATGTT

About this image

CAT expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/23 selected tissues (see all 23) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex
brain/midbrain

Uncategorized (Uncategorized) fully expand to see all 4 entries
PureStem progenitor F15

Blood (Hematopoietic System) fully expand to see all 3 entries
Hematopoietic Stem Cells Hematopoietic Bone Marrow
lung ; macrophages
BONE MARROW

Bone (Muscoskeletal System) fully expand to see all 3 entries
HyStem+BMP4-induced E15 cells
skeleton/cranium

Cartilage (Muscoskeletal System) fully expand to see all 2 entries
HyStem+BMP4-induced E15 cells
skeleton/cranium

See CAT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CAT

SOURCE GeneReport for Unigene cluster: Hs.502302

SABiosciences Expression via Pathway-Focused PCR Arrays including CAT (see all 6):

Nephrotoxicity in human mouse rat

Amino Acid Metabolism I in human mouse rat

Oxidative Stress in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Cellular Stress Responses in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for CAT OriGene qSTAR qPCR primer pairs in human, mouse for CAT
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAT

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAT gene from 10/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cat^{1 , 5}	catalase^{1, 5}	85.9(n)¹ 89.37(a)¹		2 (54.43 cM)⁵ 12359¹ NM_009804.2¹ NP_033934.2¹ 103453849⁵
chicken (Gallus gallus)	Aves	CAT¹	catalase	81.74(n) 88.26(a)		423600 NM_001031215.1 NP_001026386.1
lizard (Anolis carolinensis)	Reptilia	CAT⁶ -- (see all 3)	Uncharacterized protein (see all 3)	82(a) 82(a) (see all 3)	many → 1 many → 1 (see all 3)	GL343283.1(1401349-1429216) GL343283.1(1515885-1526112)
African clawed frog (Xenopus laevis)	Amphibia	cat-prov²	catalase	77.43(n)		BC054964.1
zebrafish (Danio rerio)	Actinopterygii	cat²	catalase	77.1(n)		30068 AF170069.1
fruit fly (Drosophila melanogaster)	Insecta	Cat^{1 , 3}	catalase reaction catalase³ Catalase¹	66(a) (best of 2)³ 63.39(n)¹ 66.73(a)¹		3 75E1³ 40048¹ NM_080483.2¹ NP_536731.1¹
worm (Caenorhabditis elegans)	Secernentea	Y54G11A.13³ ctl-2¹	catalase³ Protein CTL-2¹	62(a)³ 62.53(n)¹ 64.15(a)¹		175085¹ NM_001027302.4¹ NP_001022473.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CTA1(YDR256C)⁴ CTA1¹	Catalase A, breaks down hydrogen peroxide in the peroxisomal more⁴ Cta1p¹	53.25(n)¹ 51.15(a)¹		4(969680-968133)⁴ 851843^{1, 4} NP_010542.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	CAT1¹	catalase 1	55.96(n) 50.78(a)		838652 NM_101914.3 NP_564121.1
rice (Oryza sativa)	Liliopsida	Os.156²	Oryza sativa (japonica cultivar-group) mRNA for catalase, more	71.62(n)		AK100019.1

ENSEMBL Gene Tree for CAT (if available)
TreeFam Gene Tree for CAT (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117518779^1,2	C,F	--	34387363(+)	`GTCATT/CACTTG`	1	--	us2k¹		1		EA	120
rs141198676^1,2		--	34387472(+)	`AATCCA/CTAGTA`	1	--	us2k¹		0	--	--	--	--
rs201514859^1,2		--	34387490(+)	`AAAGG-/AAAAAA`	1	--	us2k¹		0	--	--	--	--
rs564250^1,2	C,F,A,H	--	34387523(+)	`ATGAAC/TAAAGG`	1	--	us2k¹		27		NA NS EA WA CSA	3791
rs114124398^1,2	C,F	--	34387533(+)	`GTTAAG/CAAATG`	1	--	us2k¹		1		WA	118
rs186853796^1,2		--	34387577(+)	`GTGTTC/GGTTAG`	1	--	us2k¹		0	--	--	--	--
rs191640461^1,2		--	34387979(+)	`GAAAAG/TTATAG`	1	--	us2k¹		0	--	--	--	--
rs181120344^1,2		--	34388036(+)	`AGTTCC/TACTTT`	1	--	us2k¹		0	--	--	--	--
rs17881029^1,2	C,F	--	34388134(+)	`TGTACT/CGGAAA`	1	--	us2k¹ tfbs³		3		NS WA	208
rs9282626^1,2	C,F	--	34388180(+)	`TGGTAT/CATACT`	1	--	us2k¹		11		MN NS NA WA	722

HapMap Linkage Disequilibrium report for CAT (34460472 - 34493609 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for CAT: About this table

Variant ID	Type	Subtype	PubMed ID
dgv1069n71	CNV	Gain	21882294
nsv832114	CNV	Gain	17160897
nsv825835	CNV	Gain	20364138
dgv1068n71	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): CAT

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing CAT

DNA2.0 Custom Variant and Variant Library Synthesis for CAT

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 115500 OMIM disorders: --

UniProtKB/Swiss-Prot: CATA_HUMAN, P04040

Acatalasemia (ACATLAS) [MIM:614097]: A metabolic disorder characterized by a total or near total loss of

catalase activity in red cells. It is often associated with ulcerating oral lesions. Note=The disease is caused

by mutations affecting the gene represented in this entry

20/313 diseases for CAT (see all 313): About MalaCards

pityriasis versicolor urogenital tuberculosis acatalasia diabetic cataract

pneumoconiosis meningitis and encephalitis congenital rubella favism

rubella avascular necrosis of the femoral head refsum disease digestive diseases

diabetic angiopathy merrf syndrome tetraploidy pthirus pubis infestation

senile cataract vitiligo adrenoleukodystrophy aphthous stomatitis

19 diseases from the University of Copenhagen DISEASES database for CAT:

Vascular disease Diabetes mellitus Zellweger syndrome Toxic encephalopathy

Cancer Brain disease Heart disease Lung disease

Neurodegenerative disease Hyperglycemia Chronic granulomatous disease Acatalasia

Kidney failure Infantile refsum disease Vitiligo Liver disease

Eye disease Refsum disease Spermatic cord torsion

CAT for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/92 Novoseek inferred disease relationships for CAT gene (see all 92) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
acatalasemia	77.5	12	19122680 (2), 1999334 (2), 11001624 (1), 11197178 (1), 8673475 (1), 14996832 (1), 11500062 (1), 11603354 (1) (see top 4)
hypocatalasemia	71.2	1	14996832 (1)
zellweger syndrome	71.2	10	1946426 (3), 1651504 (1), 9408912 (1), 8931469 (1), 8618694 (1), 1560037 (1), 7687405 (1) (see top 4)
peroxisomal disorders	68.3	2	2295968 (1), 8463903 (1)
cell damage	67.2	32	11729237 (2), 19917279 (2), 14675044 (2), 1958348 (1), 8005512 (1), 9789773 (1), 8034601 (1), 8403080 (1), 15852342 (1), 9649223 (1), 7834818 (1), 8279580 (1), 16784144 (1), 7959563 (1), 16630078 (1), 7638161 (1), 15927145 (1), 15454276 (1), 17401513 (1), 12871859 (1), 17334903 (1), 17640563 (1), 8611642 (1), 11896826 (1), 16602626 (1), 9294717 (1), 10628300 (1) (see top 4)
adrenoleukodystrophy neonatal	65	2	7687405 (1), 1689088 (1)
refsum disease infantile	63.9	6	7510868 (2), 9408912 (1), 1689088 (1), 7687405 (1)
peroxisome biogenesis disorders	59	4	10567403 (1), 15184617 (1), 10960480 (1)
granulomatous disease chronic	57.4	7	9864180 (1), 15135177 (1), 1370724 (1), 12706409 (1), 8872429 (1), 8315349 (1), 20367233 (1) (see top 4)
vitiligo	55.4	66	11837458 (7), 19439879 (4), 18315617 (4), 17433173 (3), 16630078 (3), 1748819 (2), 16729966 (2), 19416376 (2), 1698887 (1), 11168813 (1), 9284096 (1), 10393521 (1), 14766237 (1), 18624857 (1), 15771551 (1), 10468804 (1), 9585244 (1), 17071589 (1), 16528352 (1), 16101862 (1), 12390184 (1), 18353692 (1), 17656936 (1), 16783073 (1), 11676831 (1), 19087715 (1), 8274781 (1), 14530988 (1), 17943184 (1) (see top 4)

Genatlas disease: CAT

acatalasia

Genetic Association Database (GAD): CAT
Human Genome Epidemiology (HuGE) Navigator: CAT (269 documents)

Export disorders for CAT gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CAT gene, integrated from 9 sources (see all 3579):
(articles sorted by number of sources associating them with CAT)

Utopia: connect your pdf to the dynamic
world of online information

Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE. (PubMed id 18606005)^{1, 4, 9} D'souza A....Scofield R.H. (2008)
Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli. (PubMed id 16298864)^{1, 4, 9} Nadif R....Kauffmann F. (2005)
Genetic association of the catalase gene (CAT) with vitiligo susceptibility. (PubMed id 11837458)^{1, 4, 9} Casp C.B....McCormack W.T. (2002)
Functional variants in the catalase and myeloperoxida se genes, ambient air pollution, and respiratory-related school absences: an ex ample of epistasis in gene-environment interactions. (PubMed id 19897513)^{1, 4, 9} Wenten M....Gilliland F.D. (2009)
Associations between catalase phenotype and genotype: modification by epidemiologic factors. (PubMed id 16775184)^{1, 4, 9} Ahn J....Ambrosone C.B. (2006)
Polymorphisms in oxidative stress-related genes are not associated with prostate cancer risk in heavy smokers. (PubMed id 17548672)^{1, 4, 9} Choi J.Y....Ambrosone C.B. (2007)
Association study between catalase gene polymorphisms and the susceptibility to vitiligo in Korean population. (PubMed id 16630078)^{1, 4, 9} Park H.H....Lee M.H. (2006)
Influence of the polymorphism in candidate genes on l ate cardiac damage in patients treated due to acute leukemia in childhood. (PubMed id 19863340)^{1, 4, 9} RajiA8 V....Jazbec J. (2009)
[Lack of association between metabolic and antioxidan t gene polymorphisms (GSTM1, GSTT1, CAT, MnSOD, GPX1) and maternal quitting of smoking in pregnancy--preliminary results] (PubMed id 20301895)^{1, 4, 9} Hozyasz K.K....JagodziA8ski P.P. (2009)
Short arm of chromosome 11 and sporadic Alzheimer's disease: catalase and cathepsin D gene polymorphisms. (PubMed id 18248894)^{1, 4, 9} Capurso C....Panza F. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 847	HGNC: 1516	AceView: CAT	Ensembl:ENSG00000121691	euGenes: HUgn847
ECgene: CAT	Kegg: 847	H-InvDB: CAT

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CAT	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CAT	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Catalase
SeattleSNPs	http://pga.gs.washington.edu/data/cat/

Intellectual Property for CAT gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CAT gene:
Search GeneIP for patents involving CAT

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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Senile cataract
WILSON DISEASE
Infertility
Genetic Susceptibility
Osteomyelitis
Acute myocardial infarction
Refsum Disease Infantile
Peroxisomal Disorders
Xeroderma Pigmentosum
Polyps
ADENOCARCINOMA LUNG
Protoporphyria Erythropoietic
OXIDASE DEFICIENCY
Atherosclerosis
Ischemia
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Esophagitis
cell damage
Cancer
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Hepatitis B Chronic
RENAL DISEASE
Granulomatous Disease Chronic
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Adrenoleukodystrophy Neonatal
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Diabetic Nephropathies
Pityriasis Versicolor
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trichothiodystrophy
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Infertility Male
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clastogenesis
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NIDDM
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CAT Gene

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