Free for academic non-profit institutions. Other users need a Commercial license

CAT Gene(Protein Coding)

Catalase

GCID:
GC11P034460
GIFtS:
75
Genes Participants
UDN Logo

Aliases for CAT Gene

Aliases for CAT Gene

  • Catalase 2 3 5
  • EC 1.11.1.6 4 63

External Ids for CAT Gene

Previous GeneCards Identifiers for CAT Gene

  • GC11P036013
  • GC11P035138
  • GC11P034499
  • GC11P034424
  • GC11P034417
  • GC11P034157

Summaries for CAT Gene

Entrez Gene Summary for CAT Gene

  • This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for CAT Gene

CAT (Catalase) is a Protein Coding gene. Diseases associated with CAT include Acatalasemia and Pneumoconiosis. Among its related pathways are Purine metabolism and Glucose / Energy Metabolism. GO annotations related to this gene include protein homodimerization activity and enzyme binding.

UniProtKB/Swiss-Prot for CAT Gene

  • Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.

Gene Wiki entry for CAT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAT Gene

Genomics for CAT Gene

Products:

  1. Regulatory Element

Regulatory Elements for CAT Gene

Enhancers for CAT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAT on UCSC Golden Path with GeneCards custom track

Promoters for CAT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAT on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CAT gene promoter:

Genomic Location for CAT Gene

Chromosome:
11
Start:
34,438,925 bp from pter
End:
34,472,062 bp from pter
Size:
33,138 bases
Orientation:
Plus strand

Genomic View for CAT Gene

Genes around CAT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAT Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CAT Gene

Proteins for CAT Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04040-CATA_HUMAN
    Recommended name:
    Catalase
    Protein Accession:
    P04040
    Secondary Accessions:
    • A8K6C0
    • B2RCZ9
    • D3DR07
    • Q2M1U4
    • Q4VXX5
    • Q9BWT9
    • Q9UC85

    Protein attributes for CAT Gene

    Size:
    527 amino acids
    Molecular mass:
    59756 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Cofactor:
    Name=NADP(+); Xref=ChEBI:CHEBI:58349;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for CAT Gene

neXtProt entry for CAT Gene

Proteomics data for CAT Gene at MOPED

Protein Expression for CAT Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CAT Gene

P04040:

Post-translational modifications for CAT Gene

Other Protein References for CAT Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CAT Gene

Protein Domains for CAT Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CAT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04040

UniProtKB/Swiss-Prot:

CATA_HUMAN :
  • Belongs to the catalase family.
Family:
  • Belongs to the catalase family.
genes like me logo Genes that share domains with CAT: view

No data available for Gene Families for CAT Gene

Function for CAT Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CAT Gene

GENATLAS Biochemistry:
catalase,60kDa,peroxisomal,expressed in erythrocytes,liver,kidney,catabolic pathway of activated oxygen species,free radical detoxification
UniProtKB/Swiss-Prot CatalyticActivity:
2 H(2)O(2) = O(2) + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.

Enzyme Numbers (IUBMB) for CAT Gene

Gene Ontology (GO) - Molecular Function for CAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016209 antioxidant activity IDA 10514471
genes like me logo Genes that share ontologies with CAT: view

Phenotypes for CAT Gene

MGI mutant phenotypes for CAT:
inferred from 6 alleles
GenomeRNAi human phenotypes for CAT:
genes like me logo Genes that share phenotypes with CAT: view

Human Phenotype Ontology for CAT Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CAT Gene

MGI Knock Outs for CAT:

Animal Model Products

miRNA for CAT Gene

miRTarBase miRNAs that target CAT

Inhibitory RNA Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CAT Gene

Localization for CAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAT Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAT Gene COMPARTMENTS Subcellular localization image for CAT gene
Compartment Confidence
cytosol 5
extracellular 5
peroxisome 5
mitochondrion 4
plasma membrane 4
endoplasmic reticulum 3
lysosome 3
nucleus 3
vacuole 3
chloroplast 2
cytoskeleton 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IBA --
GO:0005778 peroxisomal membrane IEA,ISS --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with CAT: view

Pathways & Interactions for CAT Gene

genes like me logo Genes that share pathways with CAT: view

SIGNOR curated interactions for CAT Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0001649 osteoblast differentiation IDA 16210410
GO:0001666 response to hypoxia IEA --
GO:0001822 kidney development IEA --
GO:0006144 purine nucleobase metabolic process TAS --
genes like me logo Genes that share ontologies with CAT: view

Drugs & Compounds for CAT Gene

Products:

  1. Drug

(66) Drugs for CAT Gene - From: DrugBank, PharmGKB, ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fomepizole Approved Pharma Target, inhibitor 3
Ethanol Approved Pharma 1924
3-hydroxyanthranilic acid Experimental Pharma 0
Formaldehyde Experimental Pharma 78
anthracyclines and related substances Pharma 0

(93) Additional Compounds for CAT Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
 7782-44-7
superoxide
  • Dioxidanidyl
  • Dioxide(1-)
  • Hyperoxid
  • Superoxide
  • Superoxide anion
 11062-77-4
Cinnavalininate
  • 2-Amino-3-oxo-3H-phenoxazin-1,9-dicarboxylic acid
  • 2-Amino-3H-phenoxazin-one-1,9-dicarboxylic acid
  • Cinnabarinic acid
  • Cinnavalininic acid
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
methanol
  • Alcool methylique
  • Alcool metilico
  • Carbinol
  • CH3OH
  • Colonial spirit
 67-56-1
genes like me logo Genes that share compounds with CAT: view

Transcripts for CAT Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CAT Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(412) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAT Gene

Catalase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAT Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -
SP8: - - - - - -
SP9:
SP10: -
SP11:
SP12: -

ExUns: 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CAT Gene

GeneLoc Exon Structure for
CAT
ECgene alternative splicing isoforms for
CAT

Expression for CAT Gene

Products:

  1. Primer

mRNA expression in normal human tissues for CAT Gene

mRNA expression in normal human tissues for CAT Gene
mRNA expression by BioGPS for CAT GenemRNA expression by GTEx for CAT Gene

mRNA differential expression in normal tissues according to GTEx for CAT Gene

This gene is overexpressed in Liver (x5.5) and Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for CAT Gene

This gene is overexpressed in Liver, secretome (13.7) and Liver (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAT Gene



SOURCE GeneReport for Unigene cluster for CAT Gene Hs.502302

genes like me logo Genes that share expression patterns with CAT: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CAT Gene

Orthologs for CAT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia CAT 35
  • 89.75 (n)
  • 91.46 (a)
CAT 36
  • 91 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia CAT 35
  • 89.69 (n)
  • 91.65 (a)
-- 36
  • 79 (a)
 OneToMany
CAT 36
  • 92 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Cat 35
  • 85.9 (n)
  • 89.37 (a)
Cat 16
Cat 36
  • 89 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia CAT 35
  • 99.43 (n)
  • 99.43 (a)
CAT 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Cat 35
  • 85.14 (n)
  • 88.99 (a)
oppossum
(Monodelphis domestica)
 Mammalia CAT 36
  • 83 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 36
  • 87 (a)
 OneToMany
-- 36
  • 72 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves CAT 35
  • 81.74 (n)
  • 88.26 (a)
CAT 36
  • 83 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 36
  • 83 (a)
 OneToMany
-- 36
  • 73 (a)
 OneToMany
-- 36
  • 83 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia cat.2 35
  • 73.81 (n)
  • 81.97 (a)
African clawed frog
(Xenopus laevis)
 Amphibia cat-prov 35
zebrafish
(Danio rerio)
 Actinopterygii cat 35
  • 72.17 (n)
  • 78.31 (a)
cat 36
  • 78 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta Cat 37
  • 66 (a)
CG9314 37
  • 59 (a)
Cat 35
  • 63.39 (n)
  • 66.73 (a)
Cat 36
  • 66 (a)
 OneToMany
CG9314 36
  • 58 (a)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta CAT1 35
  • 62.46 (n)
  • 68.23 (a)
worm
(Caenorhabditis elegans)
 Secernentea Y54G11A.13 37
  • 62 (a)
ctl-2 35
  • 62.46 (n)
  • 64.15 (a)
ctl-1 36
  • 62 (a)
 OneToMany
ctl-2 36
  • 64 (a)
 OneToMany
ctl-3 36
  • 60 (a)
 OneToMany
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AGL256W 35
  • 54.42 (n)
  • 51.77 (a)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0D11660g 35
  • 53.8 (n)
  • 52.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes CTA1 35
  • 53.18 (n)
  • 51.15 (a)
CTA1 36
  • 48 (a)
 OneToOne
CTA1 38
thale cress
(Arabidopsis thaliana)
 eudicotyledons CAT1 35
  • 53.57 (n)
  • 46.5 (a)
soybean
(Glycine max)
 eudicotyledons Gma.2444 35
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.7958 35
barley
(Hordeum vulgare)
 Liliopsida Hv.108 35
rice
(Oryza sativa)
 Liliopsida Os.156 35
Os03g0131200 35
  • 52.45 (n)
  • 46.75 (a)
wheat
(Triticum aestivum)
 Liliopsida Ta.28032 35
corn
(Zea mays)
 Liliopsida Zm.6357 35
bread mold
(Neurospora crassa)
 Ascomycetes NCU05169 35
  • 51.74 (n)
  • 47.07 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes ctt1 35
  • 54.44 (n)
  • 52.08 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.4587 36
  • 66 (a)
 OneToOne
Species with no ortholog for CAT:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CAT Gene

ENSEMBL:
Gene Tree for CAT (if available)
TreeFam:
Gene Tree for CAT (if available)

Paralogs for CAT Gene

No data available for Paralogs for CAT Gene

Variants for CAT Gene

Sequence variations from dbSNP and Humsavar for CAT Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs524154 -- 34,442,213(-) tgaat(C/T)aataa intron-variant
rs524167 -- 34,445,991(-) GAAAA(C/T)GGACC intron-variant
rs525938 -- 34,442,046(-) caaca(A/G)ctaaa intron-variant
rs533425 -- 34,447,777(-) AAGAG(C/T)TAAAT intron-variant
rs543701 -- 34,445,232(-) GATTA(C/T)AGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAT Gene

Variant ID Type Subtype PubMed ID
dgv1068n71 CNV Gain 21882294
dgv1069n71 CNV Gain 21882294
nsv832114 CNV Gain 17160897
nsv825835 CNV Gain 20364138

Variation tolerance for CAT Gene

Residual Variation Intolerance Score: 31.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAT Gene

Human Gene Mutation Database (HGMD)
CAT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAT Gene

Disorders for CAT Gene

MalaCards: The human disease database

(62) MalaCards diseases for CAT Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acatalasemia
  • acatalasia
pneumoconiosis
pityriasis versicolor
  • infection by pityrosporum furfur
meningitis and encephalitis
congenital rubella
  • craniosynostosis
- elite association - COSMIC cancer census association via MalaCards
Search CAT in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CATA_HUMAN
  • Acatalasemia (ACATLAS) [MIM:614097]: A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. {ECO:0000269 PubMed:2308162}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for CAT Gene

acatalasia

Relevant External Links for CAT

Genetic Association Database (GAD)
CAT
Human Genome Epidemiology (HuGE) Navigator
CAT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAT
genes like me logo Genes that share disorders with CAT: view

Publications for CAT Gene

  1. Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE. (PMID: 18606005) D'souza A. … Scofield R.H. (BMC Med. Genet. 2008) 3 23 48 67
  2. Shear stress stimulates nitric oxide signaling in pulmonary arterial endothelial cells via a reduction in catalase activity: role of protein kinase C delta. (PMID: 19897742) Kumar S. … Black S.M. (Am. J. Physiol. Lung Cell Mol. Physiol. 2010) 3 23
  3. Gene polymorphisms in association with emerging cardiovascular risk markers in adult women. (PMID: 20078877) Fan A.Z. … Mokdad A.H. (BMC Med. Genet. 2010) 3 23
  4. Overexpression of catalase delays G0/G1- to S-phase transition during cell cycle progression in mouse aortic endothelial cells. (PMID: 19341793) Onumah O.E. … Guo Z. (Free Radic. Biol. Med. 2009) 3 23
  5. Catalase activity, serum trace element and heavy metal concentrations, vitamin A, vitamin D and vitamin E levels in hydatidiform mole. (PMID: 19688952) Kolusari A. … Yoruk I.H. (Clin Exp Obstet Gynecol 2009) 3 23

Products for CAT Gene

Sources for CAT Gene

Content