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Aliases for CAT Gene

Aliases for CAT Gene

  • Catalase 2 3
  • EC 4 63

External Ids for CAT Gene

Previous GeneCards Identifiers for CAT Gene

  • GC11P036013
  • GC11P035138
  • GC11P034499
  • GC11P034424
  • GC11P034417
  • GC11P034157

Summaries for CAT Gene

Entrez Gene Summary for CAT Gene

  • This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for CAT Gene

CAT (Catalase) is a Protein Coding gene. Diseases associated with CAT include acatalasemia and pityriasis versicolor. Among its related pathways are Metabolism and Glucose / Energy Metabolism. GO annotations related to this gene include protein homodimerization activity and enzyme binding.

UniProtKB/Swiss-Prot for CAT Gene

  • Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.

Gene Wiki entry for CAT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAT Gene

Genomics for CAT Gene

Regulatory Elements for CAT Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CAT Gene

34,438,925 bp from pter
34,472,062 bp from pter
33,138 bases
Plus strand

Genomic View for CAT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAT Gene

Proteins for CAT Gene

  • Protein details for CAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K6C0
    • B2RCZ9
    • D3DR07
    • Q2M1U4
    • Q4VXX5
    • Q9BWT9
    • Q9UC85

    Protein attributes for CAT Gene

    527 amino acids
    Molecular mass:
    59756 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Name=NADP(+); Xref=ChEBI:CHEBI:58349;
    Quaternary structure:
    • Homotetramer

    Three dimensional structures from OCA and Proteopedia for CAT Gene

neXtProt entry for CAT Gene

Proteomics data for CAT Gene at MOPED

Post-translational modifications for CAT Gene

Other Protein References for CAT Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CAT (Catalase)

Domains for CAT Gene

Suggested Antigen Peptide Sequences for CAT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P04040
  • Belongs to the catalase family.
genes like me logo Genes that share domains with CAT: view

No data available for Gene Families for CAT Gene

Function for CAT Gene

Molecular function for CAT Gene

GENATLAS Biochemistry: catalase,60kDa,peroxisomal,expressed in erythrocytes,liver,kidney,catabolic pathway of activated oxygen species,free radical detoxification
UniProtKB/Swiss-Prot CatalyticActivity: 2 H(2)O(2) = O(2) + 2 H(2)O.
UniProtKB/Swiss-Prot Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.

Enzyme Numbers (IUBMB) for CAT Gene

Gene Ontology (GO) - Molecular Function for CAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004046 aminoacylase activity IEA --
GO:0004096 catalase activity TAS --
GO:0005102 receptor binding IPI 20178365
GO:0016209 antioxidant activity IDA 10514471
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor ISS --
genes like me logo Genes that share ontologies with CAT: view
genes like me logo Genes that share phenotypes with CAT: view

Animal Models for CAT Gene

MGI Knock Outs for CAT:

Animal Model Products

miRNA for CAT Gene

No data available for Transcription Factor Targeting and HOMER Transcription for CAT Gene

Localization for CAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAT Gene


Subcellular locations from

Jensen Localization Image for CAT Gene COMPARTMENTS Subcellular localization image for CAT gene
Compartment Confidence
peroxisome 5
cytosol 3
extracellular 3
mitochondrion 3
nucleus 3
plasma membrane 3
chloroplast 2
cytoskeleton 2
endoplasmic reticulum 2
golgi apparatus 2
lysosome 2
vacuole 2
endosome 1

Gene Ontology (GO) - Cellular Components for CAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005758 mitochondrial intermembrane space IEA --
GO:0005764 lysosome IEA --
GO:0005777 peroxisome IDA 18379038
GO:0005778 peroxisomal membrane ISS --
genes like me logo Genes that share ontologies with CAT: view

Pathways for CAT Gene

genes like me logo Genes that share pathways with CAT: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0001649 osteoblast differentiation IDA 16210410
GO:0001657 ureteric bud development IEA --
GO:0001666 response to hypoxia IEA --
GO:0001822 kidney development --
genes like me logo Genes that share ontologies with CAT: view

Compounds for CAT Gene

(11) HMDB Compounds for CAT Gene

Compound Synonyms Cas Number PubMed IDs
3-Hydroxyanthranilic acid
  • 2-Amino-3-hydroxybenzoate
  • Cinnabarinic acid
Not Available
  • Aldeide formica
  • (protoporphyrinato)iron
Hydrogen peroxide
  • Hydrogen peroxide

(2) Drugbank Compounds for CAT Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • 4-methylpyrazole
7554-65-6 target inhibitor

(146) Novoseek inferred chemical compound relationships for CAT Gene

Compound -log(P) Hits PubMed IDs
superoxide 96.5 269
h2o2 94.6 261
oxygen 89.4 140
3-amino-1,2,4-triazole 88.1 118
malondialdehyde 87.7 254

(1) PharmGKB related drug/compound annotations for CAT Gene

Drug/compound Annotation
anthracyclines and related substances CA
genes like me logo Genes that share compounds with CAT: view

Transcripts for CAT Gene

Unigene Clusters for CAT Gene

Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAT

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAT Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -
SP8: - - - - - -
SP10: -
SP12: -

ExUns: 13a · 13b

Relevant External Links for CAT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAT Gene

mRNA expression in normal human tissues for CAT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAT Gene

This gene is overexpressed in Liver (5.5) and Whole Blood (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAT Gene

SOURCE GeneReport for Unigene cluster for CAT Gene Hs.502302

genes like me logo Genes that share expressions with CAT: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CAT Gene

Orthologs for CAT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAT Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CAT 35
  • 99.43 (n)
  • 99.43 (a)
CAT 36
  • 99 (a)
(Bos Taurus)
Mammalia CAT 35
  • 89.75 (n)
  • 91.46 (a)
CAT 36
  • 91 (a)
(Canis familiaris)
Mammalia -- 36
  • 79 (a)
CAT 35
  • 89.69 (n)
  • 91.65 (a)
CAT 36
  • 92 (a)
(Mus musculus)
Mammalia Cat 35
  • 85.9 (n)
  • 89.37 (a)
Cat 16
Cat 36
  • 89 (a)
(Monodelphis domestica)
Mammalia CAT 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
-- 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Cat 35
  • 85.14 (n)
  • 88.99 (a)
(Gallus gallus)
Aves CAT 35
  • 81.74 (n)
  • 88.26 (a)
CAT 36
  • 83 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
-- 36
  • 73 (a)
-- 36
  • 83 (a)
African clawed frog
(Xenopus laevis)
Amphibia cat-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cat.2 35
  • 73.81 (n)
  • 81.97 (a)
(Danio rerio)
Actinopterygii cat 35
  • 72.17 (n)
  • 78.31 (a)
cat 36
  • 78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta CAT1 35
  • 62.46 (n)
  • 68.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cat 35
  • 63.39 (n)
  • 66.73 (a)
Cat 36
  • 66 (a)
CG9314 36
  • 58 (a)
CG9314 37
  • 59 (a)
Cat 37
  • 66 (a)
(Caenorhabditis elegans)
Secernentea ctl-1 36
  • 62 (a)
ctl-2 35
  • 62.46 (n)
  • 64.15 (a)
ctl-2 36
  • 64 (a)
ctl-3 36
  • 60 (a)
Y54G11A.13 37
  • 62 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL256W 35
  • 54.42 (n)
  • 51.77 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTA1 35
  • 53.18 (n)
  • 51.15 (a)
CTA1 36
  • 48 (a)
CTA1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D11660g 35
  • 53.8 (n)
  • 52.95 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7958 35
(Glycine max)
eudicotyledons Gma.2444 35
thale cress
(Arabidopsis thaliana)
eudicotyledons CAT1 35
  • 53.57 (n)
  • 46.5 (a)
(Hordeum vulgare)
Liliopsida Hv.108 35
(Zea mays)
Liliopsida Zm.6357 35
(Oryza sativa)
Liliopsida Os.156 35
Os03g0131200 35
  • 52.45 (n)
  • 46.75 (a)
(Triticum aestivum)
Liliopsida Ta.28032 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05169 35
  • 51.74 (n)
  • 47.07 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ctt1 35
  • 54.44 (n)
  • 52.08 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4587 36
  • 66 (a)
Species with no ortholog for CAT:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CAT Gene

Gene Tree for CAT (if available)
Gene Tree for CAT (if available)

Paralogs for CAT Gene

No data available for Paralogs for CAT Gene

Variants for CAT Gene

Sequence variations from dbSNP and Humsavar for CAT Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs14527 -- 34,471,977(+) TACAT(C/T)AATGT utr-variant-3-prime
rs475043 -- 34,472,254(-) AAGTT(A/G)GGGCA downstream-variant-500B
rs480496 -- 34,467,282(-) TTGCG(C/T)GAAAA intron-variant
rs480575 -- 34,446,099(-) AAAGA(C/T)AGAGT intron-variant
rs482322 -- 34,445,943(-) AGATC(A/G)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAT Gene

Variant ID Type Subtype PubMed ID
dgv1068n71 CNV Gain 21882294
dgv1069n71 CNV Gain 21882294
nsv832114 CNV Gain 17160897
nsv825835 CNV Gain 20364138

Relevant External Links for CAT Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAT Gene

Disorders for CAT Gene

(1) OMIM Diseases for CAT Gene (115500)


  • Acatalasemia (ACATLAS) [MIM:614097]: A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. {ECO:0000269 PubMed:2308162}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(92) Novoseek inferred disease relationships for CAT Gene

Disease -log(P) Hits PubMed IDs
acatalasemia 77.5 10
hypocatalasemia 71.2 1
zellweger syndrome 71.2 9
peroxisomal disorders 68.3 2
cell damage 67.2 30

Genatlas disease for CAT Gene


Relevant External Links for CAT

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CAT: view

Publications for CAT Gene

  1. Vulnerability of the human airway epithelium to hyperoxia. Constitutive expression of the catalase gene in human bronchial epithelial cells despite oxidant stress. (PMID: 8282800) Yoo J.-H. … Crystal R.G. (J. Clin. Invest. 1994) 3 4 23
  2. Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism. (PMID: 10656833) Putnam C.D. … Tainer J.A. (J. Mol. Biol. 2000) 3 4 23
  3. Genetic association of the catalase gene (CAT) with vitiligo susceptibility. (PMID: 11837458) Casp C.B. … McCormack W.T. (Pigment Cell Res. 2002) 3 23 48
  4. [Associative analysis of the connection between mutation C1167T in the catalase gene and polymorphic marker D6S392 nearby the Mn-dependent superoxide dismutase gene with diabetic microangiopathies]. (PMID: 12469627) Chistiakov D.A. … Debabov V.G. (Ter. Arkh. 2002) 3 23 48
  5. Association of antioxidant enzyme gene polymorphisms and glutathione status with severe acute pancreatitis. (PMID: 15131792) Rahman S.H. … McMahon M.J. (Gastroenterology 2004) 3 23 48

Products for CAT Gene

Sources for CAT Gene

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