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CAT Gene

protein-coding GIFtS: 72

GC11P034417

catalase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 1.11.1.6 ^³
MGC138422 ^²
MGC138424 ^²
catalase ^²

External Ids
HGNC: 1516¹
Entrez Gene: 847²
UniProtKB: P04040³
Ensembl: ENSG00000121691⁷

Search outside databases for aliases for CAT gene

Previous GC identifers: GC11P036013 GC11P035138 GC11P034499 GC11P034424

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CATA_HUMAN, P04040

Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the

toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid

leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells

Gene Wiki entry for CAT (Catalase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CAT gene

Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p13

CAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P034417: (about GC identifiers)

Start:	34,417,054 bp from pter
End:	34,450,183 bp from pter
Size:	33,130 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CATA_HUMAN, P04040 (See protein sequence)

Recommended Name: Catalase

Size: 527 amino acids; 59756 Da

Cofactor: Heme group

Cofactor: NADP

Subunit: Homotetramer

Subcellular location: Peroxisome

PDB structures from and Proteopedia :

1DGB (3D)

1DGF (3D)

1DGG (3D)

1DGH (3D)

1F4J (3D)

1QQW (3D)

Secondary accessions: A8K6C0 B2RCZ9 Q2M1U4 Q4VXX5 Q9BWT9 Q9UC85

Post-translational modifications:

The N-terminus is blocked¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001743.1

ENSEMBL proteins:

ENSP00000241052

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for CAT
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Catalase)
	Human Recombinant Proteins from Abnova (CAT)

OriGene Purified Recombinant Human Protein: CAT

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005777	peroxisome	IDA	18379038
GO:0005778	peroxisomal membrane	ISS	--

About this table

Antibodies for CAT:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for CAT
	R&D Systems Antibodies for CAT (Catalase)
	Antibodies from Abcam (Catalase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CAT)
	Novus Biologicals Antibodies for CAT

Assays for CAT:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P04040

ProtoNet protein and cluster: P04040

1 Blocks protein family: IPB002226 Catalase

UniProtKB/Swiss-Prot: CATA_HUMAN, P04040

Similarity: Belongs to the catalase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CAT)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CAT)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001752

Applied Biosystems Silencer® siRNAs for CAT

Sigma-Aldrich siRNA and siRNA Panels for CAT

Sigma-Aldrich shRNA for CAT

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001752
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001752
untagged cDNA clone in CMV expression vector: NM_001752

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001752

UniProtKB/Swiss-Prot: CATA_HUMAN, P04040

Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the

toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid

leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells

Catalytic activity: 2 H(2)O(2) = O(2) + 2 H(2)O

Enzyme Number (IUBMB): EC 1.11.1.6

Genatlas biochemistry entry for CAT:

catalase,60kDa,peroxisomal,expressed in erythrocytes,liver,kidney,catabolic pathway of activated

oxygen species,free radical detoxification

2 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Cat):

cellular

homeostasis/metabolism

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004046	aminoacylase activity	IEA	--
GO:0004096	catalase activity	IDA	16644728 18312938 18379038
GO:0008083	growth factor activity	IEA	--
GO:0020037	heme binding	IDA	10656833 11134921
GO:0042803	protein homodimerization activity	IDA	10656833

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for CAT (Your Favorite Gene powered by Ingenuity) (see all 8 )

LPS/IL-1 Mediated Inhibition of RXR Function
NRF2-mediated Oxidative Stress Response
Xenobiotic Metabolism Signaling
Tryptophan Metabolism
Mitochondrial Dysfunction

GeneDecks CAT for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CAT

5/91 Interacting proteins for CAT (P04040² ENSP00000241052³) via UniProtKB, MINT, and/or STRING (see all 91 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN11	Q06124²	MINT-50693 MINT-50695 MINT-50694
SOD1	ENSP00000270142³	STRING (score=.994)
SOD2	ENSP00000337127³	STRING (score=.994)
GPX1	ENSP00000373481³	STRING (score=.951)
FOXO3	ENSP00000339527³	STRING (score=.942)

About this table

5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000302	response to reactive oxygen species	IMP	16644728
GO:0006641	triglyceride metabolic process	IEA	--
GO:0008203	cholesterol metabolic process	IEA	--
GO:0008283	cell proliferation	IEA	--
GO:0009060	aerobic respiration	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CAT
10/46 Novoseek chemical compound relationships for CAT gene (see all 46 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
superoxide	96.45	4128	2313035 (6), 17240813 (5), 7551811 (5), 10591066 (4) (see all 99)
oxygen	89.20	670	10628300 (7), 8720898 (4), 11368853 (4), 8082230 (3) (see all 99)
malondialdehyde	87.03	1018	18778500 (5), 17319275 (5), 17190187 (5), 16112416 (4) (see all 99)
xanthine	82.43	155	16130269 (3), 8710749 (2), 16112416 (2), 17571208 (2) (see all 94)
deferoxamine	82.03	166	11316574 (3), 1647676 (3), 1958348 (2), 7672482 (2) (see all 99)
manganese superoxide	81.06	115	8180777 (3), 15258423 (2), 8967746 (2), 8550376 (2) (see all 90)
lipid	80.37	567	17307156 (5), 9848047 (3), 10773913 (3), 11225659 (2) (see all 99)
dmpo	79.03	24	2176255 (2), 2170352 (1), 8314113 (1), 16443166 (1) (see all 15)
thiobarbituric acid	77.26	127	17009203 (2), 10064127 (2), 1705818 (1), 1650719 (1) (see all 83)
8-oxo-dg	77.08	31	11062173 (1), 11409938 (1), 12423653 (1), 18980879 (1) (see all 22)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CAT)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CAT)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001752

Sigma-Aldrich siRNA and siRNA Panels for CAT

Sigma-Aldrich shRNA for CAT

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001752

REFSEQ mRNAs for CAT gene:

NM_001752.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001752

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001752
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001752
                                 untagged cDNA clone in CMV expression vector: NM_001752

Additional cDNA sequence:

AK022134.1 AK291585.1 AK301577.1 AK310184.1 AK315350.1 AY028632.1 BC027300.1 BC110398.1

BC112217.1 BC112219.1 CR591917.1 CR595503.1 CR597192.1 CR602251.1 CR609505.1 CR613834.1

X04076.1

23 DOTS entries:

DT.219562 DT.100819495 DT.95261355 DT.100819489 DT.219561 DT.97835365 DT.92453028 DT.120738830

DT.219557 DT.219563 DT.95261357 DT.100819488 DT.100819491 DT.120738832 DT.449665 DT.92406951

DT.100819490 DT.75112267 DT.92453018 DT.95261354 DT.99970908 DT.100738129 DT.97858318

24/412 AceView cDNA sequences (see all 412 ):

AL545053 CB162046 CR591917 AI753159 AW768666 CR602251 CD356537 CR595503

BQ223611 BF593978 BC027300 H08508 CR613834 CR609505 BU686348 AW074278

R29244 AA235275 BG697373 AA379512 BQ576174 CA748580 BE045822 AA310030

highest scoring ESTs for CAT:

AA022516 AA127891 AA129112 AA281208 AA283011 AA447929 AA448865 AA469091 AA614808 AA627853

Unigene Cluster for CAT:

Catalase

Hs.502302 [show with all ESTs]

Unigene Representative Sequence: NM_001752

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CAT (see all 12 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	·	9d	^	10	^	11a	·	11b	·	11c	^	12	^
SP1:																																	-		-		-								-
SP2:																																	-		-		-								-				-
SP3:																																	-		-		-								-				-
SP4:									-						-
SP5:																																	-		-		-

ExUns:	13a	·	13b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for CAT

1 Ensembl transcript including schematic representation:

ENST00000241052

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CAT expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CAT

¹ / ² / ³

7 probe-sets matching CAT gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37009_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AL035079	0.20	1.00	0.72	1
201432_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001752	0.60	1.00	0.82	1
211922_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AY028632	0.80	1.00	0.91	1
215573_at*²^{, 3}	U133-A	1	1.00	1.00	--	--	AU147084	0.40	1.00	0.76	1
201432_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211922_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215573_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCTTAATGTT

SOURCE GeneReport for Unigene cluster: Hs.502302
Expression variation in blood from EXPOLDB for CAT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CAT gene from 5/25 species (see all 25 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CAT¹	--	catalase	89.69(n) 91.65(a)	403474 NM_001002984.1 NP_001002984.1
chimpanzee (Pan troglodytes)	CAT¹	--	catalase	99.43(n) 99.43(a)	451116 XM_001147928.1 XP_001147928.1
cow (Bos taurus)	CAT¹	--	catalase	89.75(n) 91.46(a)	531682 NM_001035386.1 NP_001030463.1
rat (Rattus norvegicus)	Cat¹	--	catalase	85.2(n) 88.99(a)	24248 NM_012520.1 NP_036652.1
mouse (Mus musculus)	Cat^{1, 5}	2 (57.00 cM)⁵	catalase^{1, 5}	85.9(n)¹ 88.99(a)¹	12359¹ NM_009804.1¹ NP_033934.1¹ AK075853⁵ AK088168⁵ (see all 29)

About this table Species with no ortholog for CAT

ENSEMBL Gene Tree for CAT

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/257 NCBI SNPs in CAT are shown (see all 257 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 182)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs475043^1,2	A,C,F,H,O	34450377(-)	`AAGTTA/GGGGCA`	1	--	ng3¹		17	EA NA NS EU WA	1226
	rs564250^1,2	A,C,F,H	34415437(+)	`ATGAAC/TAAAGG`	1	--	ng5¹		13	NA EU EA WA	2484
	rs7943316^1,2	A,C,F,H	34417048(+)	`CACGGA/TCTCGG`	1	--	ng5¹		12	NS EU EA WA	1122
	rs769214^1,2	A,C,F,H	34416293(+)	`CTGGGG/AGTAAA`	1	--	ng5¹		12	NA MN EU WA EA CSAM NS	1986
	rs1001179^1,2	A,C,F,H	34416807(-)	`CCCGGG/AATAGC`	1	--	ng5¹		15	EA NA MN EU WA CSAM NS	1152
	rs1049982^1,2	A,C,F	34417117(+)	`TGTTCC/TGCACA`	1	--	ut5¹		14	MN NA NS	808
	rs7104301^1,2	C,F,H	34450214(+)	`TCCATA/GTGTAA`	1	--	ng3¹		9	NA NS EU EA WA	652
	rs2234940^1,2	C,F	34449561(+)	`AGGCCA/C/G/T GGGCC`	1	--	ut3¹ ese³		6	NA MN CSAM EA	496
--	rs9282627^1,2	C,F	34416267(+)	`CAAAGC/TTTTTC`	1	--	ng5¹		7	MN CSAM EA NS	486
	rs14527^1,2	C,H	34450100(+)	`TACATT/CAATGT`	1	--	ut3¹		5	MN EU EA WA	596

About this table

HapMap Linkage Disequilibrium images for CAT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 115500

UniProtKB/Swiss-Prot: CATA_HUMAN, P04040

Defects in CAT are the cause of acatalasia (ACATLAS) [MIM:115500]; also known as

acatalasemia. This disease is characterized by absence of catalase activity in red cells and is

often associated with ulcerating oral lesions

10/93 Novoseek disease relationships for CAT gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
acatalasemia	77.53	12	19122680 (2), 1999334 (2), 11001624 (1), 11197178 (1) (see all 8)
zellweger syndrome	72.03	10	1946426 (3), 1651504 (1), 9408912 (1), 8931469 (1) (see all 7)
hypocatalasemia	71.88	1	14996832 (1)
peroxisomal disorders	67.02	2	2295968 (1), 8463903 (1)
cell damage	66.56	30	11729237 (2), 14675044 (2), 1958348 (1), 8005512 (1) (see all 26)
adrenoleukodystrophy neonatal	65.78	2	7687405 (1), 1689088 (1)
refsum disease infantile	64.62	6	7510868 (2), 9408912 (1), 1689088 (1), 7687405 (1)
peroxisome biogenesis disorders	60.46	4	10567403 (1), 15184617 (1), 10960480 (1)
granulomatous disease chronic	58.47	6	9864180 (1), 15135177 (1), 1370724 (1), 12706409 (1) (see all 6)
vitiligo	54.85	66	11837458 (7), 19439879 (4), 18315617 (4), 17433173 (3) (see all 29)

About this table

Genatlas disease: CAT

acatalasia

Human Gene Mutation Database: CAT
Genetic Association Database: CAT
Human Genome Epidemiology Navigator: CAT (165 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

Cat Exposure Increases Asthma Risk For Children Of Asthmatic Mothers

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/2337 PubMed articles for CAT gene (see all 2337 ):

Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli. (PubMed id 16298864)^{1, 3, 6} Nadif R....Kauffmann F. (2005)
Genetic association of the catalase gene (CAT) with vitiligo susceptibility. (PubMed id 11837458)^{1, 3, 6} Casp C.B....McCormack W.T. (2002)
Genetic polymorphisms of oxidative and antioxidant enzymes and arsenic-related hypertension. (PubMed id 16076760)^{1, 3, 6} Hsueh Y.M....Chen C.J. (2005)
[Associative analysis of the connection between mutation C1167T in the catalase gene and polymorphic marker D6S392 nearby the Mn-dependent superoxide dismutase gene with diabetic microangiopathies] (PubMed id 12469627)^{1, 3, 6} Chistiakov D.A....Debabov V.G. (2002)
Vulnerability of the human airway epithelium to hyperoxia. Constitutive expression of the catalase gene in human bronchial epithelial cells despite oxidant stress. (PubMed id 8282800)^{1, 3, 4} Yoo J.-H.... Crystal R.G. (1994)
A testing framework for identifying susceptibility genes in the presence of epistasis. (PubMed id 16385446)^{1, 3, 6} Millstein J....Gauderman W.J. (2006)
Genetic polymorphisms of GSTT1, GSTM1, GSTP1, MnSOD, and catalase in nonhereditary chronic pancreatitis: evidence of xenobiotic stress and impaired antioxidant capacity. (PubMed id 16047490)^{1, 3, 6} Rahman S.H....McMahon M.J. (2005)
Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer. (PubMed id 15705913)^{1, 3, 6} Ambrosone C.B....Trovato A. (2005)
[Search for the association of polymorphic markers for genes coding for antioxidant defense enzymes, with development of diabetic polyneuropathies in patients with type 1 diabetes mellitus] (PubMed id 15125229)^{1, 3, 6} Zotova E.V....Nosikov V.V. (2004)
Association of antioxidant enzyme gene polymorphisms and glutathione status with severe acute pancreatitis. (PubMed id 15131792)^{1, 3, 6} Rahman S.H....McMahon M.J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 847	HGNC: 1516	AceView: CAT	Ensembl:ENSG00000121691	euGenes: HUgn847
ECgene: CAT	H-InvDB: CAT

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CAT	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Catalase
SeattleSNPs	http://pga.gs.washington.edu/data/cat/

Licensable Technologies for CAT
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CAT:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CAT-related products

	Millipore Custom Antibody & Bulk Services
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	Millipore Immunoassay Services
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	Predesigned and custom siRNAs for CAT		Antibodies for CAT
	Explore super-pooled esiRNAs		Proteins for CAT
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	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Tagged/untagged cDNA clones
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	shRNA in GFP-retroviral vector

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Antibodies for CAT

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
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CAT Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for CAT

Summaries
for CAT

Genomic Location
for CAT

Proteins
for CAT

Protein Domains/
Families
for CAT

Gene Function
for CAT

Pathways & Interactions
for CAT

Drugs & Compounds
for CAT

Transcripts
for CAT

Expression
for CAT

Orthologs
for CAT

Paralogs
for CAT

SNPs/Variants
for CAT

Disorders & Mutations
for CAT

Medical News
for CAT

Publications
for CAT

Search for CAT

Genome Databases showing CAT

Other Databases showing CAT

Specialized Databases showing CAT

Licensable Technologies
for CAT

Services
for CAT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CAT Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor CAT

Summariesfor CAT

Genomic Locationfor CAT

Proteinsfor CAT

Protein Domains/Familiesfor CAT

Gene Functionfor CAT

Pathways & Interactionsfor CAT

Drugs & Compoundsfor CAT

Transcriptsfor CAT

Expression for CAT

Orthologsfor CAT

Paralogsfor CAT

SNPs/Variantsfor CAT

Disorders & Mutationsfor CAT

Medical Newsfor CAT

Publicationsfor CAT

Search for CAT

Genome Databases showing CAT

Other Databases showing CAT

Specialized Databases showing CAT

Licensable Technologiesfor CAT

Servicesfor CAT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CAT

Summaries
for CAT

Genomic Location
for CAT

Proteins
for CAT

Protein Domains/
Families
for CAT

Gene Function
for CAT

Pathways & Interactions
for CAT

Drugs & Compounds
for CAT

Transcripts
for CAT

Expression
for CAT

Orthologs
for CAT

Paralogs
for CAT

SNPs/Variants
for CAT

Disorders & Mutations
for CAT

Medical News
for CAT

Publications
for CAT

Licensable Technologies
for CAT

Services
for CAT