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Aliases for CASZ1 Gene

Aliases for CASZ1 Gene

  • Castor Zinc Finger 1 2 3 5
  • Zinc Finger Protein 693 2 3 4
  • Castor-Related Protein 3 4
  • ZNF693 3 4
  • CST 3 4
  • SRG 3 4
  • Castor Homolog 1, Zinc Finger (Drosophila) 2
  • Putative Survival-Related Protein 4
  • Castor Homolog 1, Zinc Finger 3
  • Survival Related Gene 2
  • Survival-Related 3
  • DJ734G22.1 3
  • CAS11 3

External Ids for CASZ1 Gene

Previous GeneCards Identifiers for CASZ1 Gene

  • GC01M009850

Summaries for CASZ1 Gene

Entrez Gene Summary for CASZ1 Gene

  • The protein encoded by this gene is a zinc finger transcription factor. The encoded protein may function as a tumor suppressor, and single nucleotide polymorphisms in this gene are associated with blood pressure variation. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for CASZ1 Gene

CASZ1 (Castor Zinc Finger 1) is a Protein Coding gene. Diseases associated with CASZ1 include retroperitoneal sarcoma and chromosome 1p36 deletion syndrome.

UniProtKB/Swiss-Prot for CASZ1 Gene

  • Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.

Gene Wiki entry for CASZ1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASZ1 Gene

Genomics for CASZ1 Gene

Regulatory Elements for CASZ1 Gene

Promoters for CASZ1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CASZ1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CASZ1 Gene

Chromosome:
1
Start:
10,636,604 bp from pter
End:
10,796,676 bp from pter
Size:
160,073 bases
Orientation:
Minus strand

Genomic View for CASZ1 Gene

Genes around CASZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASZ1 Gene

Proteins for CASZ1 Gene

  • Protein details for CASZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V15-CASZ1_HUMAN
    Recommended name:
    Zinc finger protein castor homolog 1
    Protein Accession:
    Q86V15
    Secondary Accessions:
    • Q078S9
    • Q2EN02
    • Q5T9S1
    • Q6ZNM8
    • Q8WX49
    • Q8WX50
    • Q9BT16
    • Q9NXC6

    Protein attributes for CASZ1 Gene

    Size:
    1759 amino acids
    Molecular mass:
    190069 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Endothelial cells depleted in CASZ1 by siRNAs display dramatic alterations in adhesion, morphology and sprouting; normal behavior can be rescued by restoration of EGFL7 expression. The defects are in part due to diminished RhoA expression and impaired focal adhesion localization.
    SequenceCaution:
    • Sequence=ABD14411.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAA91089.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC85474.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for CASZ1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CASZ1 Gene

Proteomics data for CASZ1 Gene at MOPED

Post-translational modifications for CASZ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CASZ1 Gene

Antibody Products

No data available for DME Specific Peptides for CASZ1 Gene

Domains & Families for CASZ1 Gene

Gene Families for CASZ1 Gene

Protein Domains for CASZ1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CASZ1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86V15

UniProtKB/Swiss-Prot:

CASZ1_HUMAN :
  • Contains 8 C2H2-type zinc fingers.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with CASZ1: view

Function for CASZ1 Gene

Molecular function for CASZ1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.
genes like me logo Genes that share phenotypes with CASZ1: view

Animal Models for CASZ1 Gene

MGI Knock Outs for CASZ1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CASZ1 Gene

Localization for CASZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CASZ1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CASZ1 Gene COMPARTMENTS Subcellular localization image for CASZ1 gene
Compartment Confidence
nucleus 5
cytosol 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for CASZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CASZ1: view

Pathways & Interactions for CASZ1 Gene

SuperPathways for CASZ1 Gene

No Data Available

Interacting Proteins for CASZ1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366221%0d%0a9606.ENSP00000263360%0d%0a9606.ENSP00000296084%0d%0a
Selected Interacting proteins: ENSP00000366221 for CASZ1 Gene via STRING

Gene Ontology (GO) - Biological Process for CASZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with CASZ1: view

No data available for Pathways by source and SIGNOR curated interactions for CASZ1 Gene

Drugs & Compounds for CASZ1 Gene

No Compound Related Data Available

Transcripts for CASZ1 Gene

Unigene Clusters for CASZ1 Gene

Castor zinc finger 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CASZ1 Gene

No ASD Table

Relevant External Links for CASZ1 Gene

GeneLoc Exon Structure for
CASZ1
ECgene alternative splicing isoforms for
CASZ1

Expression for CASZ1 Gene

mRNA expression in normal human tissues for CASZ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CASZ1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.6) and Skin - Not Sun Exposed (Suprapubic) (x5.3).

Protein differential expression in normal tissues from HIPED for CASZ1 Gene

This gene is overexpressed in Plasma (29.2), Retina (19.3), and Breast (16.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CASZ1 Gene



SOURCE GeneReport for Unigene cluster for CASZ1 Gene Hs.439894

mRNA Expression by UniProt/SwissProt for CASZ1 Gene

Q86V15-CASZ1_HUMAN
Tissue specificity: Expressed in heart, lung, skeletal muscle, pancreas, testis, small intestine, and stomach, but it is not detectable in the adult brain.
genes like me logo Genes that share expression patterns with CASZ1: view

Protein tissue co-expression partners for CASZ1 Gene

Primer Products

In Situ Assay Products

Orthologs for CASZ1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASZ1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CASZ1 35
  • 91.32 (n)
  • 92.48 (a)
CASZ1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CASZ1 35
  • 90.16 (n)
  • 91.59 (a)
CASZ1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Casz1 35
  • 88.33 (n)
  • 91.43 (a)
Casz1 16
Casz1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CASZ1 35
  • 98.37 (n)
  • 98.01 (a)
CASZ1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Casz1 35
  • 88.14 (n)
  • 91.78 (a)
oppossum
(Monodelphis domestica)
Mammalia CASZ1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CASZ1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves CASZ1 35
  • 77.89 (n)
  • 80.41 (a)
CASZ1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CASZ1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia casz1 35
  • 66.37 (n)
  • 71.33 (a)
zebrafish
(Danio rerio)
Actinopterygii casz1 35
  • 70.08 (n)
  • 71.61 (a)
wufc21h10 35
casz1 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cas 36
  • 25 (a)
OneToMany
CG7512 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
CSA.2018 36
  • 24 (a)
OneToMany
Species with no ortholog for CASZ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASZ1 Gene

ENSEMBL:
Gene Tree for CASZ1 (if available)
TreeFam:
Gene Tree for CASZ1 (if available)

Paralogs for CASZ1 Gene

Pseudogenes.org Pseudogenes for CASZ1 Gene

genes like me logo Genes that share paralogs with CASZ1: view

No data available for Paralogs for CASZ1 Gene

Variants for CASZ1 Gene

Sequence variations from dbSNP and Humsavar for CASZ1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs67969 -- 10,689,140(+) AAAAG(C/T)GTTGG intron-variant
rs182246 -- 10,777,558(+) TTACT(C/G)TGCCC intron-variant
rs184021 -- 10,718,982(-) TGAGC(A/C)GAGAT intron-variant
rs184022 -- 10,690,337(-) GCCCC(A/T)GTGTG intron-variant
rs184023 -- 10,700,012(+) aaaca(C/G)agaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CASZ1 Gene

Variant ID Type Subtype PubMed ID
dgv4n27 CNV Loss 19166990
esv29966 CNV Loss 17803354
nsv828030 CNV Gain 20364138
dgv133n71 CNV Loss 21882294
dgv134n71 CNV Loss 21882294
dgv135n71 CNV Loss 21882294
nsv464949 CNV Loss 19166990
nsv525693 CNV Loss 19592680
nsv870849 CNV Loss 21882294
nsv828141 CNV Gain 20364138
nsv828252 CNV Gain 20364138
nsv828364 CNV Gain 20364138
nsv436924 CNV Loss 16327808
nsv871904 CNV Loss 21882294
nsv832314 CNV Loss 17160897
nsv438081 CNV Loss 16468122
nsv508858 CNV Insertion 20534489
nsv818888 CNV Loss 17921354
esv2743697 CNV Deletion 23290073
esv997282 CNV Deletion 20482838
dgv18e1 CNV Complex 17122850
dgv19e1 CNV Complex 17122850
nsv8546 CNV Gain 18304495
nsv465172 CNV Loss 19166990
nsv871905 CNV Loss 21882294
nsv465283 CNV Loss 19166990
essv11784 CNV CNV 17122850
esv2743708 CNV Deletion 23290073
esv2743719 CNV Deletion 23290073
dgv136n71 CNV Loss 21882294
nsv159406 CNV Insertion 16902084

Variation tolerance for CASZ1 Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.31; 76.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CASZ1 Gene

HapMap Linkage Disequilibrium report
CASZ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASZ1 Gene

Disorders for CASZ1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CASZ1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retroperitoneal sarcoma
chromosome 1p36 deletion syndrome
  • 1p36 deletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CASZ1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CASZ1

Genetic Association Database (GAD)
CASZ1
Human Genome Epidemiology (HuGE) Navigator
CASZ1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CASZ1
genes like me logo Genes that share disorders with CASZ1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CASZ1 Gene

Publications for CASZ1 Gene

  1. Molecular cloning and characterization of human Castor, a novel human gene upregulated during cell differentiation. (PMID: 16631614) Liu Z. … Thiele C.J. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 67
  2. CASZ1, a candidate tumor-suppressor gene, suppresses neuroblastoma tumor growth through reprogramming gene expression. (PMID: 21252912) Liu Z. … Thiele C.J. (Cell Death Differ. 2011) 2 3
  3. Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension. (PMID: 25249183) Lu X. … Gu D. (Hum. Mol. Genet. 2015) 3
  4. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for CASZ1 Gene

Sources for CASZ1 Gene

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