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CASZ1 Gene

protein-coding   GIFtS: 47
GCID: GC01M010642

Castor Zinc Finger 1

(Previous names: castor homolog 1, zinc finger (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Castor Zinc Finger 11 2     Survival Related Gene1
Zinc Finger Protein 6931 2 3     CAS112
SRG2 3 5     Castor Homolog 1, Zinc Finger2
Castor-Related Protein2 3     dJ734G22.12
CST2 3     survival-related2
ZNF6932 3     Zinc Finger Protein Castor Homolog 12
Castor Homolog 1, Zinc Finger (Drosophila)1     Putative Survival-Related Protein3

External Ids:    HGNC: 260021   Entrez Gene: 548972   Ensembl: ENSG000001309407   OMIM: 6098955   UniProtKB: Q86V153   

Export aliases for CASZ1 gene to outside databases

Previous GC identifer: GC01M009850


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CASZ1 Gene:
The protein encoded by this gene is a zinc finger transcription factor. The encoded protein may function as a
tumor suppressor, and single nucleotide polymorphisms in this gene are associated with blood pressure variation.
Alternative splicing results in multiple transcript variants that encode different protein isoforms. (provided by
RefSeq, Jul 2012)

GeneCards Summary for CASZ1 Gene:
CASZ1 (castor zinc finger 1) is a protein-coding gene. Diseases associated with CASZ1 include childhood leukemia, and migraine.

UniProtKB/Swiss-Prot: CASZ1_HUMAN, Q86V15
Function: Probable transcription factor (By similarity)

Gene Wiki entry for CASZ1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CASZ1 gene promoter:
         FOXD3   Nkx2-5   POU3F2   NF-AT   AREB6   NF-AT4   SRY   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCASZ1 promoter sequence
   Search Chromatin IP Primers for CASZ1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CASZ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

CASZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CASZ1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M010642:  view genomic region     (about GC identifiers)

Start:
10,696,661 bp from pter      End:
10,856,707 bp from pter
Size:
160,047 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CASZ1_HUMAN, Q86V15 (See protein sequence)
Recommended Name: Zinc finger protein castor homolog 1  
Size: 1759 amino acids; 190069 Da
Caution: According to PubMed:16322216, another protein (SRG) is encoded on the 3'-UTR of the CASZ1 gene. The
existence of this protein that may play a role in apoptosis is extremely dubious despite the fact it was
localized in the cytoplasm with the help of a polyclonal antibody
Sequence caution: Sequence=ABD14411.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAA91089.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC85474.1; Type=Erroneous
translation; Note=Wrong choice of CDS;
Secondary accessions: Q078S9 Q2EN02 Q5T9S1 Q6ZNM8 Q8WX49 Q8WX50 Q9BT16 Q9NXC6
Alternative splicing: 2 isoforms:  Q86V15-1   Q86V15-2   

Explore the universe of human proteins at neXtProt for CASZ1: NX_Q86V15

Explore proteomics data for CASZ1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CASZ1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001073312.1  NP_060236.3  

    ENSEMBL proteins: 
     ENSP00000366221   ENSP00000467769   ENSP00000339445  

    CASZ1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    2 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q86V15

    ProtoNet protein and cluster: Q86V15

    UniProtKB/Swiss-Prot: CASZ1_HUMAN, Q86V15
    Similarity: Contains 8 C2H2-type zinc fingers


    CASZ1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CASZ1_HUMAN, Q86V15
    Function: Probable transcription factor (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    CASZ1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CASZ1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CASZ1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CASZ1

    miRNA
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    Block miRNA regulation of human, mouse, rat CASZ1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CASZ1 (see all 101):
    hsa-miR-15a hsa-miR-146a hsa-miR-371-5p hsa-miR-10b* hsa-miR-3150b-3p hsa-miR-3613-3p hsa-miR-376c hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidCASZ1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CASZ1

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    GenScript: all cDNA clones in your preferred vector (see all 2): CASZ1 (NM_017766)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASZ1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASZ1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASZ1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CASZ1_HUMAN, Q86V15: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    CASZ1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CASZ1
    Interactions:

        Search GeneGlobe Interaction Network for CASZ1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CASZ1 (ENSP000003662214) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RYKENSP000002960844STRING: ENSP00000296084
    HMGXB4ENSP000002161064STRING: ENSP00000216106
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    CASZ1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CASZ1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CASZ1 gene (3 alternative transcripts): 
    NM_001079843.2  NM_017766.4  NM_001039183.2  

    Unigene Cluster for CASZ1:

    Castor zinc finger 1
    Hs.439894  [show with all ESTs]
    Unigene Representative Sequence: NM_001079843
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377022(uc001aro.3) ENST00000478524 ENST00000447850 ENST00000344008(uc001arp.1)
    ENST00000490176 ENST00000496432(uc009vmx.2) ENST00000492173(uc001arq.1)
    ENST00000478728 ENST00000472814
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CASZ1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CASZ1 (see all 101):
    hsa-miR-15a hsa-miR-146a hsa-miR-371-5p hsa-miR-10b* hsa-miR-3150b-3p hsa-miR-3613-3p hsa-miR-376c hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidCASZ1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CASZ1
    Predesigned siRNA for gene silencing in human, mouse, rat CASZ1
    Clone
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    OriGene ORF clones in mouse, rat for CASZ1
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    GenScript: all cDNA clones in your preferred vector (see all 2): CASZ1 (NM_017766)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASZ1
    Primer
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    OriGene qPCR primer pairs and template standards for CASZ1
    OriGene qSTAR qPCR primer pairs in human, mouse for CASZ1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CASZ1
      QuantiTect SYBR Green Assays in human, mouse, rat CASZ1
      QuantiFast Probe-based Assays in human, mouse, rat CASZ1

    Additional mRNA sequence: 

    AK000328.1 AK092289.1 AK130996.1 AK225324.1 AK293839.1 AK311700.1 BC004410.1 BC051883.2 
    DQ217660.1 DQ372703.1 

    9 DOTS entries:

    DT.306457  DT.40218363  DT.428007  DT.97822597  DT.99926552  DT.121333867  DT.97775768  DT.100806496 
    DT.91638235 

    Selected AceView cDNA sequences (see all 64):

    AI671758 BQ073749 BE466522 BM978297 BM795595 AW129465 AA410866 AW516662 
    AI446176 BE676352 BC051883 BC004410 AW079610 NM_017766 BM800348 AI025065 
    AI935220 BM083391 BM793269 BQ083003 BQ188241 BQ423979 BV198881 BV198458 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CASZ1 expression in normal human tissues (normalized intensities)      CASZ1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGATGCAA
    CASZ1 Expression
    About this image


    CASZ1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Limb (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Adipose (Muscoskeletal System)
             HyStem+BMP4-induced SM30 cells
     
     Bone (Muscoskeletal System)
             HyStem+BMP4-induced SM30 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+BMP4-induced SM30 cells
     
     Skeletal Muscle (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
    CASZ1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CASZ1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.439894

    UniProtKB/Swiss-Prot: CASZ1_HUMAN, Q86V15
    Tissue specificity: Expressed in heart, lung, skeletal muscle, pancreas, testis, small intestine, and stomach, but
    it is not detectable in the adult brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASZ1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CASZ1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Casz11 , 5 castor homolog 1, zinc finger (Drosophila)5
    castor zinc finger 11
    88.33(n)1
    91.43(a)1
      4 (78.87 cM)5
    697431  NM_001159344.11  NP_001152816.11 
     1488044295 
    chicken
    (Gallus gallus)
    Aves CASZ11 castor zinc finger 1 77.89(n)
    80.41(a)
      419452  XM_004947464.1  XP_004947521.1 
    lizard
    (Anolis carolinensis)
    Reptilia CASZ16
    castor zinc finger 1
    72(a)
    1 ↔ 1
    GL343565.1(13324-100737)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia casz11 castor zinc finger 1 66.37(n)
    71.33(a)
      100127676  NM_001113014.1  NP_001106485.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc21h102 wufc21h10 83.82(n)   324216  57047493 
    fruit fly
    (Drosophila melanogaster)
    Insecta cas6
    CG75126
    --
    25(a)
    24(a)
    many → 1
    many → 1
    3R(1538664-1543022)
    3L(11506805-11512004)


    ENSEMBL Gene Tree for CASZ1 (if available)
    TreeFam Gene Tree for CASZ1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CASZ1 gene

    CASZ1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CASZ1
    PGOHUM00000247091


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CASZ1 (see all 3639)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1481904701,2
    --10696179(+) CCACCC/TTGTGC 1 -- ds50010--------
    rs1411740061,2
    C--10696210(+) GCATCC/TGGATT 1 -- ds50010--------
    rs726414411,2
    --10696229(+) GTACGC/TGCCGT 1 -- ds50010--------
    rs1503638811,2
    C--10696397(+) CCTTGC/GTGTCA 1 -- ds50010--------
    rs1380926551,2
    C--10696415(+) CTGCCC/GAAAGA 1 -- ds50010--------
    rs2015508991,2
    C--10696647(+) AAAAG-/ATATAAC 1 -- ds50010--------
    rs1862591431,2
    --10696659(+) TGATAC/GATTTT 1 -- ds50010--------
    rs1907080481,2
    --10696942(+) ATATAC/TACACA 1 -- ut310--------
    rs1819997331,2
    --10697008(+) AAAACA/GTTAAA 1 -- ut310--------
    rs1425250761,2
    --10697047(+) CCCCAC/TAGAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CASZ1 (10696661 - 10856707 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CASZ1 (see all 31):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2743708CNV Deletion23290073
    esv997282CNV Deletion20482838
    esv2743719CNV Deletion23290073
    esv2743697CNV Deletion23290073
    nsv159406CNV Insertion16902084
    nsv508858CNV Insertion20534489
    dgv135n71CNV Loss21882294
    dgv134n71CNV Loss21882294
    nsv818888CNV Loss17921354
    nsv438081CNV Loss16468122

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CASZ1
    DNA2.0 Custom Variant and Variant Library Synthesis for CASZ1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609895    OMIM disorders: --

    7 diseases for CASZ1:    About MalaCards
    childhood leukemia    migraine    neuroblastoma    lymphoblastic leukemia
    type 1 diabetes    hypertension    leukemia


    CASZ1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CASZ1
    Human Genome Epidemiology (HuGE) Navigator: CASZ1 (4 documents)

    Export disorders for CASZ1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CASZ1 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with CASZ1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human Castor, a novel human gene upregulated during cell differentiation. (PubMed id 16631614)1, 2, 3 Liu Z.... Thiele C.J. (Biochem. Biophys. Res. Commun. 2006)
    2. CASZ1, a candidate tumor-suppressor gene, suppresses neuroblastoma tumor growth through reprogramming gene expression. (PubMed id 21252912)1, 3 Liu Z....Thiele C.J. (Cell Death Differ. 2011)
    3. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. (PubMed id 21572416)1, 4 Kato N....He J. (Nat. Genet. 2011)
    4. Blood pressure and hypertension are associated with 7 loci in the Japanese population. (PubMed id 20479155)1, 4 Takeuchi F....Kato N. (Circulation 2010)
    5. Genome-wide association study of blood pressure and hypertension. (PubMed id 19430479)1, 4 Levy D....van Duijn C.M. (Nat. Genet. 2009)
    6. Association analysis of chromosome 1 migraine candidate genes. (PubMed id 17727731)1, 4 Fernandez F....Griffiths L.R. (BMC Med. Genet. 2007)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Identification and characterization of survival-related gene, a novel cell survival gene controlling apoptosis and tumorigenesis. (PubMed id 16322216)1, 2 Yuan Z.-R.... Shi Y. (Cancer Res. 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54897 HGNC: 26002 AceView: FLJ20321 Ensembl:ENSG00000130940 euGenes: HUgn54897
    ECgene: CASZ1 H-InvDB: CASZ1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CASZ1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CASZ1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CASZ1 gene:
    Search GeneIP for patents involving CASZ1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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