Aliases for CASTOR2 Gene
External Ids for CASTOR2 Gene
Previous HGNC Symbols for CASTOR2 Gene
GeneCards Summary for CASTOR2 Gene
CASTOR2 (Cytosolic Arginine Sensor For MTORC1 Subunit 2) is a Protein Coding gene. An important paralog of this gene is CASTOR1.
UniProtKB/Swiss-Prot for CASTOR2 Gene
Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.