Aliases for CASTOR2 Gene
Aliases for CASTOR2 Gene
External Ids for CASTOR2 Gene
- HGNC: 37073
- Entrez Gene: 729438
- Ensembl: ENSG00000274070
- OMIM: 617033
- UniProtKB: A6NHX0
Previous HGNC Symbols for CASTOR2 Gene
- GATSL1
- GATSL2
Summaries for CASTOR2 Gene
GeneCards Summary for CASTOR2 Gene
CASTOR2 (Cytosolic Arginine Sensor For MTORC1 Subunit 2) is a Protein Coding gene. An important paralog of this gene is CASTOR1.
UniProtKB/Swiss-Prot for CASTOR2 Gene
-
Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with GATSL3, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to GATSL3 disrupts the interaction of GATSL2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASTOR2 Gene
Genomics for CASTOR2 Gene
Regulatory Elements for CASTOR2 Gene
Enhancers for CASTOR2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH07G074997 | 0.6 | Ensembl | 0.3 | +33.3 | 33283 | 0.6 | FOSL1 SMARCE1 ARID1B SMARCA4 ADNP IKZF1 NFE2 DPF2 | PIR40795 GC07P075020 GC07P075019 GC07P075018 CASTOR2 |
| GH07G074993 | 0.6 | Ensembl | 0.3 | +29.6 | 29583 | 2.0 | ZNF146 NFIB ZNF223 ZBTB8A ZNF398 ZNF7 GLIS1 ZNF580 FOS SP7 | STAG3L2 GTF2IP1 PIR40795 GC07P075020 GC07P075019 GC07P075018 CASTOR2 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CASTOR2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CASTOR2 Gene
- Chromosome:
- 7
- Start:
- 74,964,818 bp from pter
- End:
- 75,031,532 bp from pter
- Size:
- 66,715 bases
- Orientation:
- Plus strand
Genomic View for CASTOR2 Gene
Genes around CASTOR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q11.23 by Ensembl
- 7q11.23 by Entrez Gene
- 7q11.23 by HGNC
CASTOR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CASTOR2 Gene
Proteins for CASTOR2 Gene
-
Protein details for CASTOR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6NHX0-GATL2_HUMAN
- Recommended name:
- GATS-like protein 2
- Protein Accession:
- A6NHX0
- A6NNH0
- B9EJH9
Protein attributes for CASTOR2 Gene
- Size:
- 329 amino acids
- Molecular mass:
- 36056 Da
- Quaternary structure:
-
- Forms homodimers and heterodimers with GATSL3 (PubMed:26972053). Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is not regulated by arginine (PubMed:26972053).
Post-translational modifications for CASTOR2 Gene
Other Protein References for CASTOR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CASTOR2
- Invitrogen Antibodies for CASTOR2
- Search GeneTex for Antibodies for CASTOR2
Protein Products
-
OriGene Purified Proteins for CASTOR2
- Search Origene for MassSpec and Protein Over-expression Lysates for CASTOR2
- Origene Custom Protein Services for CASTOR2
- Search GeneTex for Proteins for CASTOR2
Assay Products
No data available for DME Specific Peptides for CASTOR2 Gene
Domains & Families for CASTOR2 Gene
Protein Domains for CASTOR2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CASTOR2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
A6NHX0- Family:
-
- Belongs to the GATS family.
No data available for Gene Families for CASTOR2 Gene
Function for CASTOR2 Gene
Molecular function for CASTOR2 Gene
- UniProtKB/Swiss-Prot Function:
- Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with GATSL3, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to GATSL3 disrupts the interaction of GATSL2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 26972053 |
| GO:0034618 | NOT arginine binding | IDA | 26972053 |
| GO:0042802 | identical protein binding | IDA | 26972053 |
Phenotypes for CASTOR2 Gene
- GenomeRNAi human phenotypes for CASTOR2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CASTOR2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CASTOR2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CASTOR2 gene
- Search ViGene Biosciences for CASTOR2
CRISPR Products
-
OriGene CRISPR knockouts for CASTOR2
- GenScript: Design CRISPR guide RNA sequences for CASTOR2
miRNA for CASTOR2 Gene
- miRTarBase miRNAs that target CASTOR2
-
- mmu-mir-7b-5p (MIRT009463)
- mmu-mir-324-3p (MIRT011040)
- mmu-mir-24-3p (MIRT013986)
- mmu-mir-3065-5p (MIRT578772)
- mmu-mir-183-5p (MIRT600846)
- mmu-mir-329-3p (MIRT600847)
- mmu-mir-362-3p (MIRT600848)
- mmu-mir-709 (MIRT600849)
- mmu-mir-1935 (MIRT600850)
- mmu-mir-298-5p (MIRT600851)
- mmu-mir-5135 (MIRT604970)
- mmu-mir-665-3p (MIRT604971)
miRNA Products
- Search ViGene Biosciences for CASTOR2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CASTOR2
- Browse OriGene Inhibitory RNA Products For CASTOR2
-
ViGene Biosciences ready-to-package AAV shRNAs for CASTOR2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CASTOR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CASTOR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CASTOR2
-
ViGene Biosciences adenoviral particle packaged cDNA for CASTOR2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CASTOR2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CASTOR2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CASTOR2 Gene
Localization for CASTOR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CASTOR2 Gene
- Cytoplasm, cytosol.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IEA,IDA | 26972053 |
| GO:0061700 | colocalizes_with GATOR2 complex | IDA | 26972053 |
Pathways & Interactions for CASTOR2 Gene
No Data Available
Interacting Proteins for CASTOR2 Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| CASTOR1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1904262 | negative regulation of TORC1 signaling | IMP | 26972053 |
No data available for Pathways by source and SIGNOR curated interactions for CASTOR2 Gene
Transcripts for CASTOR2 Gene
mRNA/cDNA for CASTOR2 Gene
- (2) REFSEQ mRNAs :
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CASTOR2
- GenScript: Design CRISPR guide RNA sequences for CASTOR2
miRNA Products
- Search ViGene Biosciences for CASTOR2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CASTOR2
- Browse OriGene Inhibitory RNA Products For CASTOR2
-
ViGene Biosciences ready-to-package AAV shRNAs for CASTOR2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CASTOR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CASTOR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CASTOR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Natural Killer Cells Peripheral Blood
NURSA nuclear receptor signaling pathways regulating expression of CASTOR2 Gene:
CASTOR2mRNA Expression by UniProt/SwissProt for CASTOR2 Gene:
A6NHX0-GATL2_HUMAN
Tissue specificity:
Widely expressed.
Primer Products
-
OriGene qPCR primer pairs for CASTOR2
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CASTOR2 Gene
Orthologs for CASTOR2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GATSL2 34 |
|
||
| cow (Bos Taurus) |
Mammalia | GATSL2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Gatsl2 16 34 |
|
||
| dog (Canis familiaris) |
Mammalia | GATSL2 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gatsl2 34 |
|
||
| chicken (Gallus gallus) |
Aves | GATSL2 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gatsl1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gatsl2 34 |
|
- Species where no ortholog for CASTOR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CASTOR2 Gene
Variants for CASTOR2 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000195451 | -- | 75,020,905(+) | GATCC(A/G)CATGT | intron-variant | |
| rs1000303158 | -- | 75,026,008(+) | TAGTT(C/G)TATCT | intron-variant, utr-variant-3-prime | |
| rs1000374940 | -- | 75,026,343(+) | CACCA(C/T)CACGT | intron-variant, utr-variant-3-prime | |
| rs1000609984 | -- | 75,020,740(+) | CGCCC(C/T)GGCCT | intron-variant | |
| rs1000639066 | -- | 75,025,007(+) | TCATC(C/T)GGCCT | intron-variant, utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv11452n54 | CNV | loss | 21841781 |
| dgv3593n106 | CNV | deletion | 24896259 |
| esv1398337 | CNV | insertion | 17803354 |
| esv2658348 | CNV | deletion | 23128226 |
| nsv1032137 | CNV | gain | 25217958 |
| nsv1075033 | CNV | deletion | 25765185 |
| nsv1075972 | CNV | deletion | 25765185 |
| nsv1112935 | CNV | deletion | 24896259 |
| nsv1119128 | CNV | deletion | 24896259 |
| nsv1145144 | CNV | deletion | 24896259 |
| nsv7402 | OTHER | inversion | 18451855 |
| nsv8145 | CNV | gain | 18304495 |
| nsv950552 | CNV | deletion | 24416366 |
| nsv951355 | CNV | deletion | 24416366 |
| nsv970534 | CNV | duplication | 23825009 |
| nsv970537 | CNV | duplication | 23825009 |
| nsv970882 | CNV | duplication | 23825009 |
| nsv981529 | CNV | duplication | 23825009 |
| nsv981530 | CNV | duplication | 23825009 |
| nsv981533 | CNV | duplication | 23825009 |
| nsv981668 | CNV | duplication | 23825009 |
Gene Damage Index Score:
0.20;
4.51% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CASTOR2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CASTOR2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASTOR2 Gene
Disorders for CASTOR2 Gene
Relevant External Links for CASTOR2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CASTOR2
No disorders were found for CASTOR2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CASTOR2 Gene
Publications for CASTOR2 Gene
- The CASTOR proteins are arginine sensors for the mTORC1 pathway. (PMID: 26972053) Chantranupong L. … Sabatini D.M. (Cell 2016) 2 3 4 64
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
Products for CASTOR2 Gene
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- OriGene Purified Proteins for CASTOR2
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- Origene Custom Protein Services for CASTOR2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CASTOR2
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- OriGene qPCR primer pairs for CASTOR2
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- Novus Biologicals Antibodies for CASTOR2
- Novus Biologicals
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- ViGene Biosciences adenoviral particle packaged cDNA for CASTOR2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CASTOR2 gene
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- Horizon Cell Lines for CASTOR2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CASTOR2
- VectorBuilder custom plasmid, inducible vectors for CASTOR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CASTOR2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CASTOR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
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- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
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- (100) COMPARTMENTS
- (101) HOMER
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- (109) TreeFam
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- (141) ENCODE
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- (146) Cyagen
- (147) VectorBuilder
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- (151) CIViC
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer