Aliases for CASTOR1 Gene
External Ids for CASTOR1 Gene
Previous HGNC Symbols for CASTOR1 Gene
GeneCards Summary for CASTOR1 Gene
CASTOR1 (Cytosolic Arginine Sensor For MTORC1 Subunit 1) is a Protein Coding gene. An important paralog of this gene is CASTOR2.
UniProtKB/Swiss-Prot for CASTOR1 Gene
Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with GATSL2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to GATSL3 allosterically disrupts the interaction of GATSL3-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.