Aliases for CASTOR1 Gene
Aliases for CASTOR1 Gene
External Ids for CASTOR1 Gene
- HGNC: 34423
- Entrez Gene: 652968
- Ensembl: ENSG00000239282
- OMIM: 617034
- UniProtKB: Q8WTX7
Previous HGNC Symbols for CASTOR1 Gene
- GATSL3
Summaries for CASTOR1 Gene
GeneCards Summary for CASTOR1 Gene
CASTOR1 (Cytosolic Arginine Sensor For MTORC1 Subunit 1) is a Protein Coding gene. An important paralog of this gene is CASTOR2.
UniProtKB/Swiss-Prot for CASTOR1 Gene
-
Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with GATSL2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to GATSL3 allosterically disrupts the interaction of GATSL3-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASTOR1 Gene
Genomics for CASTOR1 Gene
Regulatory Elements for CASTOR1 Gene
Enhancers for CASTOR1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CASTOR1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CASTOR1 Gene
- Chromosome:
- 22
- Start:
- 30,285,117 bp from pter
- End:
- 30,289,627 bp from pter
- Size:
- 4,511 bases
- Orientation:
- Minus strand
Genomic View for CASTOR1 Gene
Genes around CASTOR1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.2 by Ensembl
- 22q12.2 by Entrez Gene
- 22q12.2 by HGNC
CASTOR1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CASTOR1 Gene
Proteins for CASTOR1 Gene
-
Protein details for CASTOR1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WTX7-GATL3_HUMAN
- Recommended name:
- GATS-like protein 3
- Protein Accession:
- Q8WTX7
- O76052
- Q96ND9
- Q9UIE8
Protein attributes for CASTOR1 Gene
- Size:
- 329 amino acids
- Molecular mass:
- 36275 Da
- Quaternary structure:
-
- Forms homodimers and heterodimers with GATSL2 (PubMed:26972053, PubMed:27487210). Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by arginine (PubMed:26972053, PubMed:27487210).
- SequenceCaution:
-
- Sequence=AAC23432.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC23433.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB70963.1; Type=Erroneous termination; Positions=310; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=EAW59868.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Post-translational modifications for CASTOR1 Gene
Other Protein References for CASTOR1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CASTOR1
- Novus Biologicals Antibodies for CASTOR1
- Search GeneTex for Antibodies for CASTOR1
Protein Products
-
OriGene Purified Proteins for CASTOR1
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- Origene Custom Protein Services for CASTOR1
- Search GeneTex for Proteins for CASTOR1
Assay Products
No data available for DME Specific Peptides for CASTOR1 Gene
Domains & Families for CASTOR1 Gene
Protein Domains for CASTOR1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CASTOR1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WTX7UniProtKB/Swiss-Prot:
GATL3_HUMAN :- Based on x-ray crystallography data, the protein would be constituted of 4 tandem ACT domains instead of the 2 predicted from the sequence.
- Belongs to the GATS family.
- Domain:
-
- Based on x-ray crystallography data, the protein would be constituted of 4 tandem ACT domains instead of the 2 predicted from the sequence.
- Family:
-
- Belongs to the GATS family.
No data available for Gene Families for CASTOR1 Gene
Function for CASTOR1 Gene
Molecular function for CASTOR1 Gene
- UniProtKB/Swiss-Prot Function:
- Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with GATSL2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to GATSL3 allosterically disrupts the interaction of GATSL3-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0034618 | arginine binding | IDA | 26972053 |
| GO:0042802 | identical protein binding | IDA,IPI | 25416956 |
Phenotypes for CASTOR1 Gene
- MGI mutant phenotypes for CASTOR1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CASTOR1:
Animal Models for CASTOR1 Gene
- MGI Knock Outs for CASTOR1:
-
- Gatsl3 tm1.1(KOMP)Vlcg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CASTOR1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CASTOR1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CASTOR1 gene
- Search ViGene Biosciences for CASTOR1
CRISPR Products
-
OriGene CRISPR knockouts for CASTOR1
- GenScript: Design CRISPR guide RNA sequences for CASTOR1
miRNA Products
- Search ViGene Biosciences for CASTOR1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CASTOR1
- Browse OriGene Inhibitory RNA Products For CASTOR1
-
ViGene Biosciences ready-to-package AAV shRNAs for CASTOR1 gene
Clone Products
-
OriGene ORF clones in human for CASTOR1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CASTOR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CASTOR1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CASTOR1
-
ViGene Biosciences adenoviral particle packaged cDNA for CASTOR1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CASTOR1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CASTOR1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CASTOR1 Gene
Localization for CASTOR1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CASTOR1 Gene
- Cytoplasm, cytosol.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IEA,IDA | 26972053 |
| GO:0061700 | colocalizes_with GATOR2 complex | IDA | 26972053 |
Pathways & Interactions for CASTOR1 Gene
No Data Available
Interacting Proteins for CASTOR1 Gene
Selected Interacting proteins:
ENSP00000384183
Q8WTX7-GATL3_HUMAN
for CASTOR1 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903577 | cellular response to L-arginine | IMP | 26972053 |
| GO:1904262 | negative regulation of TORC1 signaling | IMP | 26972053 |
No data available for Pathways by source and SIGNOR curated interactions for CASTOR1 Gene
Transcripts for CASTOR1 Gene
mRNA/cDNA for CASTOR1 Gene
- (1) REFSEQ mRNAs :
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CASTOR1
- GenScript: Design CRISPR guide RNA sequences for CASTOR1
miRNA Products
- Search ViGene Biosciences for CASTOR1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CASTOR1
- Browse OriGene Inhibitory RNA Products For CASTOR1
-
ViGene Biosciences ready-to-package AAV shRNAs for CASTOR1 gene
Clone Products
-
OriGene ORF clones in human for CASTOR1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CASTOR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CASTOR1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CASTOR1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CASTOR1 Gene:
CASTOR1mRNA Expression by UniProt/SwissProt for CASTOR1 Gene:
Q8WTX7-GATL3_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for CASTOR1 Gene
- Lung(4.1)
- Nervous system(2.7)
Primer Products
-
OriGene qPCR primer pairs and template standards for CASTOR1
-
OriGene qPCR primer pairs for CASTOR1
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CASTOR1 Gene
Orthologs for CASTOR1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GATSL3 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | GATSL3 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GATSL3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | GATSL3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Gatsl3 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gatsl3 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GATSL3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GATSL3 34 35 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gatsl3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gatsl3 34 |
|
- Species where no ortholog for CASTOR1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CASTOR1 Gene
Variants for CASTOR1 Gene
| SNP ID | Clin | Chr 22 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000389680 | -- | 30,287,670(+) | GGGCA(G/T)GTCTG | intron-variant | |
| rs1000404870 | -- | 30,286,064(+) | CTCCC(C/T)CGAGG | reference, missense | |
| rs1000404940 | -- | 30,287,955(+) | CATTC(A/G)CAGAT | intron-variant | |
| rs1001116980 | -- | 30,290,587(+) | AAGGC(A/T)AAGCA | upstream-variant-2KB | |
| rs1002474096 | -- | 30,287,610(+) | CCTGC(A/C)CCTCT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2676362 | CNV | deletion | 23128226 |
| nsv1062388 | CNV | gain | 25217958 |
| nsv1110864 | OTHER | inversion | 24896259 |
| nsv522605 | CNV | loss | 19592680 |
| nsv588885 | CNV | loss | 21841781 |
| nsv829171 | CNV | loss | 20364138 |
| nsv834174 | CNV | gain+loss | 17160897 |
Residual Variation Intolerance Score:
48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.16;
61.58% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CASTOR1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CASTOR1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASTOR1 Gene
Disorders for CASTOR1 Gene
Relevant External Links for CASTOR1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CASTOR1
No disorders were found for CASTOR1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CASTOR1 Gene
Publications for CASTOR1 Gene
- The CASTOR proteins are arginine sensors for the mTORC1 pathway. (PMID: 26972053) Chantranupong L. … Sabatini D.M. (Cell 2016) 2 3 4 64
- Mechanism of arginine sensing by CASTOR1 upstream of mTORC1. (PMID: 27487210) Saxton R.A. … Sabatini D.M. (Nature 2016) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for CASTOR1 Gene
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- Custom Antibody ServicesOriGene Antibodies for CASTOR1
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- OriGene Purified Proteins for CASTOR1
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- OriGene qPCR primer pairs and template standards for CASTOR1
- OriGene qPCR primer pairs for CASTOR1
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- Novus Biologicals Antibodies for CASTOR1
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- Horizon Cell Lines for CASTOR1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CASTOR1
- VectorBuilder custom plasmid, inducible vectors for CASTOR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CASTOR1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CASTOR1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (18) KEGG
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- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
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- (100) COMPARTMENTS
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