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Aliases for CAST Gene

Aliases for CAST Gene

  • Calpastatin 2 3
  • Sperm BS-17 Component 3 4
  • Calpain Inhibitor 3 4
  • BS-17 3
  • PLACK 3

External Ids for CAST Gene

Previous GeneCards Identifiers for CAST Gene

  • GC05P095228
  • GC05P096462
  • GC05P096026
  • GC05P096085
  • GC05P096105
  • GC05P096036
  • GC05P095865
  • GC05P091188

Summaries for CAST Gene

Entrez Gene Summary for CAST Gene

  • The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

GeneCards Summary for CAST Gene

CAST (Calpastatin) is a Protein Coding gene. Diseases associated with CAST include peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads and cheilitis. Among its related pathways are Neuroscience and DREAM Repression and Dynorphin Expression. GO annotations related to this gene include poly(A) RNA binding and cysteine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for CAST Gene

  • Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue

Gene Wiki entry for CAST Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAST Gene

Genomics for CAST Gene

Regulatory Elements for CAST Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CAST Gene

Chromosome:
5
Start:
96,525,267 bp from pter
End:
96,779,595 bp from pter
Size:
254,329 bases
Orientation:
Plus strand

Genomic View for CAST Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAST Gene

Proteins for CAST Gene

  • Protein details for CAST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20810-ICAL_HUMAN
    Recommended name:
    Calpastatin
    Protein Accession:
    P20810
    Secondary Accessions:
    • B7Z468
    • G5E946
    • G5E9D3
    • O95360
    • Q05DE8
    • Q7Z4K0
    • Q96D08
    • Q9H1Z5

    Protein attributes for CAST Gene

    Size:
    708 amino acids
    Molecular mass:
    76573 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH16066.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for CAST Gene

neXtProt entry for CAST Gene

Proteomics data for CAST Gene at MOPED

Post-translational modifications for CAST Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CAST (calpastatin)

No data available for DME Specific Peptides for CAST Gene

Domains & Families for CAST Gene

Protein Domains for CAST Gene

Graphical View of Domain Structure for InterPro Entry

P20810

UniProtKB/Swiss-Prot:

ICAL_HUMAN :
  • Each of the four flexible inhibitory domains can inhibit one calcium-bound calpain molecule by occupying both sides of the active site.
  • Belongs to the protease inhibitor I27 (calpastatin) family.
Domain:
  • Each of the four flexible inhibitory domains can inhibit one calcium-bound calpain molecule by occupying both sides of the active site.
Family:
  • Belongs to the protease inhibitor I27 (calpastatin) family.
genes like me logo Genes that share domains with CAST: view

No data available for Gene Families for CAST Gene

Function for CAST Gene

Molecular function for CAST Gene

GENATLAS Biochemistry:
calpastatin,calcium dependent cysteine endopeptidase,calpain inhibitor
UniProtKB/Swiss-Prot Function:
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue

Gene Ontology (GO) - Molecular Function for CAST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA --
GO:0004866 endopeptidase inhibitor activity TAS 7638179
GO:0005515 protein binding IPI 17474147
GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CAST: view
genes like me logo Genes that share phenotypes with CAST: view

Animal Models for CAST Gene

MGI Knock Outs for CAST:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAST

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CAST Gene

Localization for CAST Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAST Gene COMPARTMENTS Subcellular localization image for CAST gene
Compartment Confidence
cytosol 4
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
mitochondrion 2
nucleus 2
plasma membrane 2
vacuole 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CAST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA 14559243
GO:0016020 membrane IDA 14559243
genes like me logo Genes that share ontologies with CAST: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CAST Gene

Pathways & Interactions for CAST Gene

genes like me logo Genes that share pathways with CAST: view

Pathways by source for CAST Gene

1 Qiagen pathway for CAST Gene
1 Cell Signaling Technology pathway for CAST Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CAST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0007343 egg activation IEA --
GO:0007420 brain development IEA --
GO:0007520 myoblast fusion IEA --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with CAST: view

No data available for SIGNOR curated interactions for CAST Gene

Drugs & Compounds for CAST Gene

(11) Drugs for CAST Gene - From: NovoSeek, ClinicalTrials, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mitomycin Approved Pharma Inhibits DNA synthesis,antibiotic and antitumor agent 0
Citrulline Approved Nutra Full agonist, Agonist 0
cyclic amp Experimental Pharma 0
Calcium Nutra Target 0
Cola Nutra 1690

(20) Additional Compounds for CAST Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5fluorouracil
Agarose
cacl2
Calpeptin
117591-20-5
Cimaterol
genes like me logo Genes that share compounds with CAST: view

Transcripts for CAST Gene

Unigene Clusters for CAST Gene

Calpastatin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAST

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAST Gene

No ASD Table

Relevant External Links for CAST Gene

GeneLoc Exon Structure for
CAST
ECgene alternative splicing isoforms for
CAST

Expression for CAST Gene

mRNA expression in normal human tissues for CAST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAST Gene

This gene is overexpressed in Muscle - Skeletal (x4.0).

Protein differential expression in normal tissues from HIPED for CAST Gene

This gene is overexpressed in Nasal epithelium (13.7), Peripheral blood mononuclear cells (8.4), and Lavage (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAST Gene



SOURCE GeneReport for Unigene cluster for CAST Gene Hs.436186

genes like me logo Genes that share expression patterns with CAST: view

Protein tissue co-expression partners for CAST Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CAST Gene

Orthologs for CAST Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAST Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAST 35
  • 82.4 (n)
  • 77.67 (a)
CAST 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAST 35
  • 84.5 (n)
  • 79.59 (a)
CAST 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cast 35
  • 78.85 (n)
  • 71.01 (a)
Cast 16
Cast 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAST 35
  • 98.93 (n)
  • 98 (a)
CAST 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cast 35
  • 75.37 (n)
  • 67.09 (a)
oppossum
(Monodelphis domestica)
Mammalia CAST 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAST 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAST 35
  • 61.17 (n)
  • 49.78 (a)
CAST 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAST 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cast 35
  • 56.49 (n)
  • 48.5 (a)
Str.96 35
African clawed frog
(Xenopus laevis)
Amphibia calp3 35
zebrafish
(Danio rerio)
Actinopterygii cast 36
  • 22 (a)
OneToOne
Species with no ortholog for CAST:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAST Gene

ENSEMBL:
Gene Tree for CAST (if available)
TreeFam:
Gene Tree for CAST (if available)

Paralogs for CAST Gene

No data available for Paralogs for CAST Gene

Variants for CAST Gene

Sequence variations from dbSNP and Humsavar for CAST Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_005298 -
VAR_022686 -
VAR_030741 -
VAR_030742 -

Structural Variations from Database of Genomic Variants (DGV) for CAST Gene

Variant ID Type Subtype PubMed ID
nsv509982 CNV Loss 20534489
nsv830411 CNV Loss 17160897
nsv516293 CNV Gain+Loss 19592680
nsv819693 CNV Loss 19587683
nsv436983 CNV Loss 16327808

Variation tolerance for CAST Gene

Residual Variation Intolerance Score: 87.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAST Gene

HapMap Linkage Disequilibrium report
CAST
Human Gene Mutation Database (HGMD)
CAST

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAST Gene

Disorders for CAST Gene

MalaCards: The human disease database

(5) MalaCards diseases for CAST Gene - From: OMIM, ClinVar, DISEASES, NovoSeek, and GeneCards

- elite association
Search CAST in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ICAL_HUMAN
  • Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK) [MIM:616295]: An autosomal recessive disease characterized by generalized, continuous shedding of the outer layers of the epidermis, leukonychia, acral punctate keratosis, cheilitis, knuckle pads with multiple hyperkeratotic micropapules involving the interphalangeal joints, and palmoplantar keratoderma. {ECO:0000269 PubMed:25683118}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CAST

Genetic Association Database (GAD)
CAST
Human Genome Epidemiology (HuGE) Navigator
CAST
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAST
genes like me logo Genes that share disorders with CAST: view

No data available for Genatlas for CAST Gene

Publications for CAST Gene

  1. Four promoters direct expression of the calpastatin gene. (PMID: 15820218) Raynaud P. … Amarger V. (Arch. Biochem. Biophys. 2005) 2 23 67
  2. Changes in calpastatin localization and expression during calpain activation: a new mechanism for the regulation of intracellular Ca(2+)-dependent proteolysis. (PMID: 14685690) Averna M. … Melloni E. (Cell. Mol. Life Sci. 2003) 2 23 67
  3. Requirement of different subdomains of calpastatin for calpain inhibition and for binding to calmodulin-like domains. (PMID: 8340353) Ma H. … Maki M. (J. Biochem. 1993) 2 23 67
  4. The endogenous modulators of Ca2+-Mg2+-dependent ATPase in children with chronic kidney disease (CKD). (PMID: 19854852) Polak-Jonkisz D. … Zwolinska D. (Nephrol. Dial. Transplant. 2010) 23 67
  5. The role of calpain-calpastatin system in the development of stress urinary incontinence. (PMID: 19756344) Wu Y. … Xie Z. (Int Urogynecol J 2010) 23 67

Products for CAST Gene

Sources for CAST Gene

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