Aliases for CAST Gene
External Ids for CAST Gene
Previous GeneCards Identifiers for CAST Gene
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
GeneCards Summary for CAST Gene
CAST (Calpastatin) is a Protein Coding gene. Among its related pathways are Neuroscience and DREAM Repression and Dynorphin Expression. GO annotations related to this gene include endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity.
UniProtKB/Swiss-Prot for CAST Gene
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue