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Aliases for CAST Gene

Aliases for CAST Gene

  • Calpastatin 2 3
  • Sperm BS-17 Component 3 4
  • Calpain Inhibitor 3 4
  • BS-17 3
  • PLACK 3

External Ids for CAST Gene

Previous GeneCards Identifiers for CAST Gene

  • GC05P095228
  • GC05P096462
  • GC05P096026
  • GC05P096085
  • GC05P096105
  • GC05P096036
  • GC05P095865
  • GC05P091188

Summaries for CAST Gene

Entrez Gene Summary for CAST Gene

  • The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

GeneCards Summary for CAST Gene

CAST (Calpastatin) is a Protein Coding gene. Among its related pathways are Neuroscience and DREAM Repression and Dynorphin Expression. GO annotations related to this gene include endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for CAST Gene

  • Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue

Gene Wiki entry for CAST Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAST Gene

Genomics for CAST Gene

Regulatory Elements for CAST Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CAST Gene

Start:
96,525,267 bp from pter
End:
96,779,595 bp from pter
Size:
254,329 bases
Orientation:
Plus strand

Genomic View for CAST Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAST Gene

Proteins for CAST Gene

  • Protein details for CAST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20810-ICAL_HUMAN
    Recommended name:
    Calpastatin
    Protein Accession:
    P20810
    Secondary Accessions:
    • B7Z468
    • G5E946
    • G5E9D3
    • O95360
    • Q05DE8
    • Q7Z4K0
    • Q96D08
    • Q9H1Z5

    Protein attributes for CAST Gene

    Size:
    708 amino acids
    Molecular mass:
    76573 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH16066.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for CAST Gene

neXtProt entry for CAST Gene

Proteomics data for CAST Gene at MOPED

Post-translational modifications for CAST Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CAST (calpastatin)

No data available for DME Specific Peptides for CAST Gene

Domains for CAST Gene

Protein Domains for CAST Gene

Graphical View of Domain Structure for InterPro Entry

P20810

UniProtKB/Swiss-Prot:

ICAL_HUMAN :
  • P20810
Domain:
  • Each of the four flexible inhibitory domains can inhibit one calcium-bound calpain molecule by occupying both sides of the active site.
Family:
  • Belongs to the protease inhibitor I27 (calpastatin) family.
genes like me logo Genes that share domains with CAST: view

No data available for Gene Families for CAST Gene

Function for CAST Gene

Molecular function for CAST Gene

GENATLAS Biochemistry: calpastatin,calcium dependent cysteine endopeptidase,calpain inhibitor
UniProtKB/Swiss-Prot Function: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue

Gene Ontology (GO) - Molecular Function for CAST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity TAS 7638179
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 17474147
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CAST: view
genes like me logo Genes that share phenotypes with CAST: view

Animal Models for CAST Gene

MGI Knock Outs for CAST:

Animal Model Products

miRNA for CAST Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAST

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CAST Gene

Localization for CAST Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAST Gene COMPARTMENTS Subcellular localization image for CAST gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
plasma membrane 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CAST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA 14559243
GO:0016020 membrane IDA 14559243
genes like me logo Genes that share ontologies with CAST: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CAST Gene

Pathways for CAST Gene

genes like me logo Genes that share pathways with CAST: view

Pathways by source for CAST Gene

1 Qiagen pathway for CAST Gene
1 Cell Signaling Technology pathway for CAST Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CAST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity --
GO:0010951 negative regulation of endopeptidase activity TAS 7638179
GO:2000675 negative regulation of type B pancreatic cell apoptotic process IDA 15044459
genes like me logo Genes that share ontologies with CAST: view

Compounds for CAST Gene

(1) HMDB Compounds for CAST Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for CAST Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Calcium
target

(29) Novoseek inferred chemical compound relationships for CAST Gene

Compound -log(P) Hits PubMed IDs
calpeptin 82.4 8
e 64d 70.4 2
cysteine 67.1 17
mdl 28170 64.8 1
cimaterol 61 4
genes like me logo Genes that share compounds with CAST: view

Transcripts for CAST Gene

Unigene Clusters for CAST Gene

Calpastatin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAST

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CAST

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAST Gene

No ASD Table

Relevant External Links for CAST Gene

GeneLoc Exon Structure for
CAST
ECgene alternative splicing isoforms for
CAST

Expression for CAST Gene

mRNA expression in normal human tissues for CAST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAST Gene

This gene is overexpressed in Muscle - Skeletal (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAST Gene

SOURCE GeneReport for Unigene cluster for CAST Gene Hs.436186

genes like me logo Genes that share expressions with CAST: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CAST Gene

Orthologs for CAST Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAST Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAST 35
  • 98.93 (n)
  • 98 (a)
CAST 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAST 35
  • 82.4 (n)
  • 77.67 (a)
CAST 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAST 35
  • 84.5 (n)
  • 79.59 (a)
CAST 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cast 35
  • 78.85 (n)
  • 71.01 (a)
Cast 16
Cast 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAST 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAST 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cast 35
  • 75.37 (n)
  • 67.09 (a)
chicken
(Gallus gallus)
Aves CAST 35
  • 61.17 (n)
  • 49.78 (a)
CAST 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAST 36
  • 43 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia calp3 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cast 35
  • 56.49 (n)
  • 48.5 (a)
Str.96 35
zebrafish
(Danio rerio)
Actinopterygii cast 36
  • 22 (a)
OneToOne
Species with no ortholog for CAST:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAST Gene

ENSEMBL:
Gene Tree for CAST (if available)
TreeFam:
Gene Tree for CAST (if available)

Paralogs for CAST Gene

No data available for Paralogs for CAST Gene

Variants for CAST Gene

Sequence variations from dbSNP and Humsavar for CAST Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs9667 -- 96,695,865(+) AGTCA(A/G)TCCTC reference, synonymous-codon, utr-variant-5-prime
rs10835 -- 96,729,161(+) TCTGT(G/T)GTTCA intron-variant, reference, synonymous-codon
rs26345 -- 96,747,634(-) CTAGT(A/G)TGCAA intron-variant
rs26482 -- 96,682,252(-) TGTCA(A/G)CAAAA intron-variant
rs26483 -- 96,680,912(-) GACAT(A/G)AGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAST Gene

Variant ID Type Subtype PubMed ID
nsv509982 CNV Loss 20534489
nsv830411 CNV Loss 17160897
nsv516293 CNV Gain+Loss 19592680
nsv819693 CNV Loss 19587683
nsv436983 CNV Loss 16327808

Relevant External Links for CAST Gene

HapMap Linkage Disequilibrium report
CAST
Human Gene Mutation Database (HGMD)
CAST

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAST Gene

Disorders for CAST Gene

(2) University of Copenhagen DISEASES for CAST Gene

(24) Novoseek inferred disease relationships for CAST Gene

Disease -log(P) Hits PubMed IDs
muscular dystrophies 39 1
muscle necrosis 34.4 1
rheumatoid arthritis 33.9 10
alzheimers disease 31.3 8
pathological processes 31.2 1

Relevant External Links for CAST

Genetic Association Database (GAD)
CAST
Human Genome Epidemiology (HuGE) Navigator
CAST
genes like me logo Genes that share disorders with CAST: view

No data available for UniProtKB/Swiss-Prot for CAST Gene

Publications for CAST Gene

  1. Phosphorylation and subcellular distribution of calpastatin in human hematopoietic system cells. (PMID: 1995645) Adachi Y. … Hatanaka M. (J. Biol. Chem. 1991) 3 4 23
  2. Requirement of different subdomains of calpastatin for calpain inhibition and for binding to calmodulin-like domains. (PMID: 8340353) Ma H. … Maki M. (J. Biochem. 1993) 2 3 23
  3. Detection and expression of a cDNA clone that encodes a polypeptide containing two inhibitory domains of human calpastatin and its recognition by rheumatoid arthritis sera. (PMID: 7706496) Despres N. … Menard H.A. (J. Clin. Invest. 1995) 3 4 23
  4. Calpastatin gene in human testis. (PMID: 7951045) Wang L.F. … Koide S.S. (Biochem. Mol. Biol. Int. 1994) 3 4 23
  5. Mutation analysis of the calpastatin gene (CAST) in patients with Alzheimer's disease. (PMID: 11849768) Nakayama J. … Arinami T. (Neurosci. Lett. 2002) 3 23 48

Products for CAST Gene

Sources for CAST Gene

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