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CASS4 Gene

protein-coding   GIFtS: 47
GCID: GC20P054987

Cas Scaffolding Protein Family Member 4

(Previous name: chromosome 20 open reading frame 32)
(Previous symbol: C20orf32)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cas Scaffolding Protein Family Member 41 2     HEF1-EFS-P130Cas-Like Protein2 3
C20orf321 2 3     HEF1-Efs-p130Cas-like1
HEF-Like Protein1 2 3     Chromosome 20 Open Reading Frame 321
HEFL2 3     CAS42
HEPL2 3     

External Ids:    HGNC: 158781   Entrez Gene: 570912   Ensembl: ENSG000000875897   UniProtKB: Q9NQ753   

Export aliases for CASS4 gene to outside databases

Previous GC identifers: GC20P054421 GC20P051772


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CASS4 Gene:
CASS4 (Cas scaffolding protein family member 4) is a protein-coding gene. GO annotations related to this gene include phosphorelay sensor kinase activity. An important paralog of this gene is BCAR1.

UniProtKB/Swiss-Prot: CASS4_HUMAN, Q9NQ75
Function: Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell
spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CASS4 gene promoter:
         AML1a   GCNF   Lmo2   Meis-1b   FAC1   GCNF-1   Meis-1a   GCNF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCASS4 promoter sequence
   Search Chromatin IP Primers for CASS4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CASS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.31   Ensembl cytogenetic band:  20q13.2   HGNC cytogenetic band: 20q13.31

CASS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CASS4 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P054987:  view genomic region     (about GC identifiers)

Start:
54,987,168 bp from pter      End:
55,034,396 bp from pter
Size:
47,229 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CASS4_HUMAN, Q9NQ75 (See protein sequence)
Recommended Name: Cas scaffolding protein family member 4  
Size: 786 amino acids; 87144 Da
Subunit: Interacts (via SH3 domain) with PTK2/FAK1 (via C-terminus)
Sequence caution: Sequence=CAC00655.1; Type=Frameshift; Positions=336, 342;
1 PDB 3D structure from and Proteopedia for CASS4:
2CRE (3D)    
Secondary accessions: E1P5Z8 Q5QPD6 Q96K09 Q9BYL5
Alternative splicing: 3 isoforms:  Q9NQ75-1   Q9NQ75-2   Q9NQ75-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CASS4: NX_Q9NQ75

Explore proteomics data for CASS4 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosines by SRC1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CASS4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001157586.1  NP_001157587.1  NP_001157588.1  NP_065089.2  

    ENSEMBL proteins: 
     ENSP00000353462   ENSP00000410027   ENSP00000360387  

    CASS4 Human Recombinant Protein Products:

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    Novus Biologicals CASS4 Protein
    Novus Biologicals CASS4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CASS4 

     
    antibodies-online proteins for CASS4 (2 products) 

     
    antibodies-online peptides for CASS4

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    antibodies-online antibodies for CASS4 (11 products) 

    CASS4 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CASS4 
    antibodies-online kits for CASS4 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CASS: Cas scaffolding proteins

    4 InterPro protein domains:
     IPR014928 Serine_rich
     IPR001452 SH3_domain
     IPR003661 EnvZ-like_dim/P
     IPR021901 CAS_DUF3513

    Graphical View of Domain Structure for InterPro Entry Q9NQ75

    ProtoNet protein and cluster: Q9NQ75

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: CASS4_HUMAN, Q9NQ75
    Similarity: Belongs to the CAS family
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with CASS4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CASS4_HUMAN, Q9NQ75
    Function: Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell
    spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000155phosphorelay sensor kinase activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CASS4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CASS4:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CASS4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CASS4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CASS4

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CASS4:
    hsa-miR-130b* hsa-miR-3119
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): CASS4 (NM_020356)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASS4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CASS4_HUMAN, Q9NQ75: Cytoplasm, cytoskeleton. Cell junction, focal adhesion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005925focal adhesion IEA--
    GO:0016020membrane IEA--

    Find genes that share ontologies with CASS4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CASS4
    Interactions:

        Search GeneGlobe Interaction Network for CASS4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CASS4 (Q9NQ753 ENSP000003534624) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    Find genes that share ontologies with CASS4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CASS4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CASS4 gene (4 alternative transcripts): 
    NM_001164114.1  NM_001164115.1  NM_001164116.1  NM_020356.3  

    Unigene Cluster for CASS4:

    Cas scaffolding protein family member 4
    Hs.473144  [show with all ESTs]
    Unigene Representative Sequence: NM_001164116
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360314 ENST00000434344 ENST00000497244(uc002xxq.4) ENST00000371336(uc002xxp.2 uc010zze.1 uc002xxr.2 uc010gio.2)

    miRNA
    Products:
         
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    2 qRT-PCR Assays for microRNAs that regulate CASS4:
    hsa-miR-130b* hsa-miR-3119
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): CASS4 (NM_020356)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASS4
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CASS4
      QuantiTect SYBR Green Assays in human, mouse, rat CASS4
      QuantiFast Probe-based Assays in human, mouse, rat CASS4

    Additional mRNA sequence: 

    AJ276678.1 AK027760.1 AK295613.1 AK308057.1 AK314653.1 BC027951.1 

    5 DOTS entries:

    DT.97781524  DT.92012542  DT.120801562  DT.100646240  DT.200911 

    7 AceView cDNA sequences:

    BX280195 BC027951 BI768239 CB154772 AJ276678 NM_020356 AK027760 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CASS4 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
    SP1:        -     -                 -                 -                                   -               
    SP2:                                -                 -                       -     -     -               
    SP3:                                -                 -                                                   
    SP4:                                -     -           -                                                   
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for CASS4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CASS4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCACGGA
    CASS4 Expression
    About this image

    CASS4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CASS4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473144

    UniProtKB/Swiss-Prot: CASS4_HUMAN, Q9NQ75
    Tissue specificity: Expressed abundantly in lung and spleen. Also highly expressed in ovarian and leukemia cell
    lines

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CASS4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cass41 , 5 Cas scaffolding protein family member 41, 5 74.47(n)1
    66.93(a)1
      2 (94.85 cM)5
    3206641  NM_001276422.11  NP_001263351.11 
     1723937945 
    chicken
    (Gallus gallus)
    Aves CASS41 Cas scaffolding protein family member 4 58.13(n)
    47.19(a)
      419330  XM_004947229.1  XP_004947286.1 
    lizard
    (Anolis carolinensis)
    Reptilia CASS46
    Cas scaffolding protein family member 4
    34(a)
    1 ↔ 1
    GL343217.1(1968591-1993912)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cass41 Cas scaffolding protein family member 4 53.92(n)
    42.36(a)
      100490791  XM_002942273.2  XP_002942319.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000009381 cas scaffolding protein family member 4-like 49.52(n)
    39.52(a)
      100000938  XM_001341002.2  XP_001341038.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta p130CAS6
    p130CAS
    20(a)
    1 → many
    3L(152884-174517)


    ENSEMBL Gene Tree for CASS4 (if available)
    TreeFam Gene Tree for CASS4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CASS4 gene
    BCAR12  NEDD92  EFS2  
    1 SIMAP similar gene for CASS4 using alignment to 1 protein entry:     CASS4_HUMAN:
    SH3GL2

    Find genes that share paralogs with CASS4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CASS4 (see all 1195)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440609501,2
    C--54985186(+) ACTGCC/TGGGAG 1 -- us2k10--------
    rs1839237231,2
    --54985259(+) GAATTC/TAGTTT 1 -- us2k10--------
    rs60991331,2
    F--54985303(+) aagttA/Tatcca 1 -- us2k10--------
    rs1422259141,2
    --54985497(+) GTATAC/GTTCAA 4 -- us2k10--------
    rs60147211,2
    --54985798(+) caaaaA/Taaata 4 -- us2k1 tfbs30--------
    rs1512208891,2
    C--54985865(+) TATTAC/TTATTA 4 -- us2k10--------
    rs586445681,2
    --54985930(+) ATTGCA/GTGGGG 4 -- us2k10--------
    rs60991371,2
    --54985968(+) TCGCCG/TGCAGC 4 -- us2k10--------
    rs37612061,2
    C,F,H--54986220(+) GACAAG/AAAGAT 4 -- us2k112Minor allele frequency- A:0.25EA NS NA 2600
    rs1450107311,2
    --54986270(+) TTGAGA/CCTGGC 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for CASS4 (54987168 - 55034396 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CASS4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675000CNV Deletion23128226
    esv267778CNV Insertion20981092
    esv29379CNV Loss19812545
    dgv249n21CNV Loss19592680
    nsv525175CNV Loss19592680
    nsv834013CNV Gain17160897
    nsv525425CNV Gain19592680
    nsv518442CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CASS4
    DNA2.0 Custom Variant and Variant Library Synthesis for CASS4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with CASS4           About GenesLikeMe

    Genetic Association Database (GAD): CASS4

    Export disorders for CASS4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CASS4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CASS4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel Cas family member, HEPL, regulates FAK and cell spreading. (PubMed id 18256281)1, 2 Singh M.K.... Golemis E.A. (Mol. Biol. Cell 2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Overexpression and cytoplasmic accumulation of Hepl is associated with clinicopathological parameters and poor prognosis in non-small cell lung cancer. (PubMed id 23001926)1 Miao Y....Wang E.H. (Tumour Biol. 2013)
    6. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    7. Phosphoproteome of resting human platelets. (PubMed id 18088087)2 Zahedi R.P.... Sickmann A. (J. Proteome Res. 2008)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57091 HGNC: 15878 AceView: C20orf32 Ensembl:ENSG00000087589 euGenes: HUgn57091
    ECgene: CASS4 H-InvDB: CASS4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CASS4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CASS4 gene:
    Search GeneIP for patents involving CASS4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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