Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CASR Gene

protein-coding   GIFtS: 69
GCID: GC03P121820

Calcium-Sensing Receptor

(Previous name: hypocalciuric hypercalcemia 1)
(Previous symbols: HHC, HHC1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calcium-Sensing Receptor1 2     Severe Neonatal Hyperparathyroidism1
HHC11 2 5     CAR2
PCAR12 3 5     FHH2
HHC1 2     HYPOC12
Parathyroid Cell Calcium-Sensing Receptor2 3     NSHPT2
GPRC2A2 3     Extracellular Calcium-Sensing Receptor2
EIG82 5     Parathyroid Ca(2+)-Sensing Receptor 12
FIH2 5     CaSR3
Hypocalciuric Hypercalcemia 11     PCaR13

External Ids:    HGNC: 15141   Entrez Gene: 8462   Ensembl: ENSG000000368287   OMIM: 6011995   UniProtKB: P411803   

Export aliases for CASR gene to outside databases

Previous GC identifers: GC03P118638 GC03P123183 GC03P123223 GC03P123385 GC03P119276


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CASR Gene:
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone
(PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small
changes in circulating calcium concentration and couples this information to intracellular signaling pathways
that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining
mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated
hypoparathyroidism, and neonatal severe primary hyperparathyroidism. (provided by RefSeq, Jul 2008)

GeneCards Summary for CASR Gene: 
CASR (calcium-sensing receptor) is a protein-coding gene. Diseases associated with CASR include hypercalcemia, and familial hypocalciuric hypercalcemia, and among its related super-pathways are Signaling by GPCR and Gastrin-CREB signalling pathway via PKC and MAPK. GO annotations related to this gene include G-protein coupled receptor activity and phosphatidylinositol phospholipase C activity.

UniProtKB/Swiss-Prot: CASR_HUMAN, P41180
Function: Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is
mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system

summary for CASR Gene:
Activation of an ERK signaling pathway often involves regulation of cell division, migration and survival;
dysregulation of these pathways has been associated with various diseases, including cancer. ERK signaling
has also been linked to the positive regulation of synaptic plasticity and long-term potentiation (LTP).

Gene Wiki entry for CASR (Calcium-sensing receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CASR gene promoter:
         AP-1   POU2F1   Pax-5   FOXO4   POU2F1a   HFH-1   Ik-3   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCASR promoter sequence
   Search SABiosciences Chromatin IP Primers for CASR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13   Ensembl cytogenetic band:  3q21.1   HGNC cytogenetic band: 3q21.1

CASR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CASR gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P121820:  view genomic region     (about GC identifiers)

Start:
121,902,530 bp from pter      End:
122,005,344 bp from pter
Size:
102,815 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CASR_HUMAN, P41180 (See protein sequence)
Recommended Name: Extracellular calcium-sensing receptor precursor  
Size: 1078 amino acids; 120674 Da
Subunit: Interacts with VCP and RNF19A. Interacts with ARRB1 (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q13912 Q16108 Q16109 Q16110 Q16379 Q2M1T0 Q4PJ19
Alternative splicing: 2 isoforms:  P41180-1   P41180-2   

Explore the universe of human proteins at neXtProt for CASR: NX_P41180

Explore proteomics data for CASR at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • UniProtKB: Ubiquitinated by RNF19A; which induces proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P41180

  • CASR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CASR Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000379.2  NP_001171536.1  

    ENSEMBL proteins: 
     ENSP00000418685   ENSP00000420194   ENSP00000296154  
    Reactome Protein details: P41180
    Human Recombinant Protein Products for CASR: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CASR
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CASR
    GenScript Custom Purified and Recombinant Proteins Services for CASR
    Novus Biologicals CASR Proteins
    Novus Biologicals CASR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CASR 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7759551
    GO:0016021integral to membrane ----
    GO:0043679axon terminus ----

    CASR for ontologies           About GeneDecksing



    CASR Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CASR
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CASR
    OriGene Custom Antibody Services for CASR
    GenScript Custom Superior Antibodies Services for CASR
    Novus Biologicals CASR Antibodies
    Abcam antibodies for CASR
    Cloud-Clone Corp. Antibodies for CASR 
    ThermoFisher Antibody for CASR
    LSBio Antibodies in human, mouse, rat for CASR 

    Assay Products for CASR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CASR
    Browse R&D Systems for biochemical assays
    GenScript CASR-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CASR 
    Cloud-Clone Corp. CLIAs for CASR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CASR: GPCR / Class C : Calcium-sensing receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: CaS receptor 
    Calcium-sensing receptors

    5 InterPro protein domains:
     IPR011500 GPCR_3_9-Cys_dom
     IPR000337 GPCR_3
     IPR017979 GPCR_3_CS
     IPR017978 GPCR_3_C
     IPR001828 ANF_lig-bd_rcpt

    Graphical View of Domain Structure for InterPro Entry P41180

    ProtoNet protein and cluster: P41180

    3 Blocks protein domains:
    IPB000068 Extracellular calcium-sensing receptor signature
    IPB000337 G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: CASR_HUMAN, P41180
    Similarity: Belongs to the G-protein coupled receptor 3 family


    CASR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CASR_HUMAN, P41180
    Function: Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is
    mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system

         Genatlas biochemistry entry for CASR:
    extracellular calcium sensing receptor gene 1,bovine homolog,expressed in parathyroid cells,C cells of
    thyroid,also expressed in kidney on the basolateral surface of cells of the thick ascending limbs,and on the
    luminal surface of cells of the papillary collecting duct,also expressed in the brain,in pancreatic islet B cells
    and putatively involved in the regulation of insulin release,G protein coupled receptor superfamily,activating
    phospholipase C

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity TAS7874174
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005515protein binding IPI--
         
    CASR for ontologies           About GeneDecksing


    Phenotypes:
         15/16 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Casr) (see all 16):
     behavior/neurological  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
     muscle  other  pigmentation  renal/urinary system  skeleton 

    CASR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Casrtm1Ces for CASR

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CASR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CASR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CASR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CASR 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CASR:
    hsa-mir-31 (MIRT004597)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CASR
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate CASR (see all 16):
    hsa-miR-429 hsa-miR-15a hsa-miR-503 hsa-miR-497 hsa-miR-646 hsa-miR-200c hsa-miR-424 hsa-miR-369-3p
    SwitchGear 3'UTR luciferase reporter plasmidCASR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CASR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CASR
    Sirion Biotech Customized adenovirus for overexpression of CASR

    Clone
    Products:
         
    EMD Millipore Clones for the Expression of CASR
    OriGene clones in human, mouse for CASR (see all 10)
    OriGene ORF clones in mouse, rat for CASR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CASR (NM_001178065)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASR
    Sirion Biotech Customized lentivirus for stable overexpression of CASR 
                         Customized lentivirus expression plasmids for stable overexpression of CASR 

    Cell Line
    Products:
         
    GenScript CASR-overexpressing Cell Line for Assay
    Search LifeMap BioReagents cell lines for CASR
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CASR About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3Class A/1 (Rhodopsin-like receptors)
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    4Class C/3 (Metabotropic glutamate/pheromone receptors)
    Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
    5Synaptic Neurotransmission: Glutamatergic Excitation
    GPCRs, Class C Metabotropic glutamate, pheromone0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CASR
        GPCRs, Class C Metabotropic glutamate, pheromone
    E-cadherin signaling in keratinocytes

    5/8        Reactome Pathways for CASR (see all 8)
        GPCR downstream signaling
    Signal Transduction
    Gastrin-CREB signalling pathway via PKC and MAPK
    G alpha (q) signalling events
    Class C/3 (Metabotropic glutamate/pheromone receptors)

    1 PharmGKB Pathway for CASR
        Proton Pump Inhibitor Pathway, Pharmacodynamics


    CASR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CASR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/258 Interacting proteins for CASR (P411801, 3 ENSP000002961544) via UniProtKB, MINT, STRING, and/or I2D (see all 258)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF19AQ9NV583, ENSP000003426674I2D: score=2 STRING: ENSP00000342667
    CHD8Q9HCK83, ENSP000004062884I2D: score=1 STRING: ENSP00000406288
    PRKCBP057713, ENSP000003053554I2D: score=1 STRING: ENSP00000305355
    PRKCGP051293, ENSP000002634314I2D: score=1 STRING: ENSP00000263431
    VCPP550723, ENSP000003517774I2D: score=1 STRING: ENSP00000351777
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification TAS7874174
    GO:0005513detection of calcium ion TAS7759551
    GO:0006816calcium ion transport ----
    GO:0006874cellular calcium ion homeostasis TAS7874174
    GO:0007186G-protein coupled receptor signaling pathway TAS7759551

    CASR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CASR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CASR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Calhex 231 hydrochlorideNegative allosteric modulator of the calcium-sensing receptor[652973-93-8]
    Strontium chlorideCalcium sensing receptor (CaSR) agonist[10476-85-4]
    NPS 2143 hydrochlorideSelective antagonist of the calcium-sensing receptor; orally active calcilytic agent[284035-33-2]
    R 568 hydrochloridePositive allosteric modulator of the human calcium-sensing receptor[177172-49-5]

    1 HMDB Compound for CASR    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for CASR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cinacalcet-- 226256-56-0targetagonist16030053 19461861 15884662 19181759 15864123 11752352 15794735 19056615 19261825 16109140

    10/11 IUPHAR Ligands for CASR (CaS receptor) (see all 11)    About this table 
    LigandTypeActionAffinityPubmed IDs
    AC265347
    Allosteric regulatorPositive7.6 - 8.121239511
    NPS 2143
    AntagonistAntagonist7.1 - 7.415686947 11561095
    cinacalcet
    Allosteric regulatorPositive7.314593085
    2-methyl-3-phenethyl-3H-pyrimidin-4-one (cmp 2H)
    AntagonistAntagonist715863312
    compound (S)-3h [PMID:15686947]
    AntagonistAntagonist6.915686947
    NPS R-568
    Allosteric regulatorPositive6.59520489
    calindol
    Allosteric regulatorPositive6.514976203
    calhex 231
    Allosteric regulatorNegative6.414506236
    L-tryptophan
    Allosteric regulatorPositive2.6 - 4.410781086 15234970
    spermine
    AgonistFull agonist3.59357776

    10/58 Novoseek inferred chemical compound relationships for CASR gene (see all 58)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cinacalcet 93.3 34 15864123 (2), 15794735 (1), 18634360 (1), 15689407 (1) (see all 26)
    calcium 84.6 1733 16316325 (7), 12815330 (7), 17693759 (7), 17054460 (6) (see all 99)
    vitamin d 79.9 116 19621386 (6), 19706842 (3), 10971456 (3), 16109139 (2) (see all 66)
    calcitriol 71 13 18556746 (2), 10372837 (1), 12386262 (1), 18199601 (1) (see all 10)
    22-oxacalcitriol 68.1 1 11799271 (1)
    prepro-pth 67.6 1 9916869 (1)
    strontium ranelate 65.4 16 19563530 (2), 15985213 (1), 17437947 (1), 18378206 (1)
    neomycin 64.6 18 17537980 (2), 19088423 (2), 18096456 (1), 18577871 (1) (see all 11)
    phosphorus 61.7 11 15794735 (1), 16232374 (1), 19560849 (1), 8076142 (1) (see all 8)
    sevelamer 58.3 1 15669206 (1)

    Search CenterWatch for drugs/clinical trials and news about CASR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CASR gene (2 alternative transcripts): 
    NM_000388.3  NM_001178065.1  

    Unigene Cluster for CASR:

    Calcium-sensing receptor
    Hs.435615  [show with all ESTs]
    Unigene Representative Sequence: NM_001178065
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490131 ENST00000498619(uc003eev.4 uc003eew.4) ENST00000490186
    ENST00000296154

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CASR
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate CASR (see all 16):
    hsa-miR-429 hsa-miR-15a hsa-miR-503 hsa-miR-497 hsa-miR-646 hsa-miR-200c hsa-miR-424 hsa-miR-369-3p
    SwitchGear 3'UTR luciferase reporter plasmidCASR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CASR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASR
    Clone
    Products:
         
    OriGene clones in human, mouse for CASR (see all 10)
    OriGene ORF clones in mouse, rat for CASR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CASR (NM_001178065)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASR
    Sirion Biotech Customized lentivirus for stable overexpression of CASR 
                         Customized lentivirus expression plasmids for stable overexpression of CASR 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CASR
    OriGene qSTAR qPCR primer pairs in human, mouse for CASR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CASR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CASR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASR

    Additional mRNA sequence: 

    BC104999.1 BC112236.1 D50855.1 FJ360896.1 S79217.1 S81755.1 S83176.1 U20759.1 
    U20760.1 

    5 DOTS entries:

    DT.91724033  DT.313332  DT.97825513  DT.306656  DT.40259118 

    24/53 AceView cDNA sequences (see all 53):

    S83176 NM_000388 AA297525 CK903922 BM052980 W56898 BV183242 BX100952 
    AA724807 U20760 AA781707 CD608329 AA843293 AA844290 BF594614 AA846660 
    CK903923 AA854191 AA782127 S81755 D50855 BM052703 AA862999 AI766210 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CASR    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
    SP1:                                          
    SP2:                          -               


    ECgene alternative splicing isoforms for CASR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CASR expression in normal human tissues (normalized intensities)      CASR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTCGTCAT
    CASR Expression
    About this image


    CASR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Thyroid (Endocrine System)
             parathyroid gland   
     
     Spinal Cord (Nervous System)
             Ventral Horn   
     
     Kidney (Urinary System)

    See CASR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CASR

    SOURCE GeneReport for Unigene cluster: Hs.435615

    UniProtKB/Swiss-Prot: CASR_HUMAN, P41180
    Tissue specificity: Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also
    found in kidney, lung, liver, heart, skeletal muscle, placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including CASR: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CASR
    OriGene qSTAR qPCR primer pairs in human, mouse for CASR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CASR
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CASR
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CASR gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Casr1 , 5 calcium-sensing receptor1, 5 87.63(n)1
    93.88(a)1
      16 (25.57 cM)5
    123741  NM_013803.21  NP_038831.21 
     364936965 
    chicken
    (Gallus gallus)
    Aves CASR1 calcium-sensing receptor 80.34(n)
    87.45(a)
      418266  XM_416491.3  XP_416491.3 
    lizard
    (Anolis carolinensis)
    Reptilia CASR6
    Uncharacterized protein
    84(a)
    1 ↔ 1
    GL343218.1(261563-303937)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5606071 extracellular calcium-sensing receptor-like 70.46(n)
    76.06(a)
      560607  XM_684005.2  XP_689097.1 


    ENSEMBL Gene Tree for CASR (if available)
    TreeFam Gene Tree for CASR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CASR gene
    13 SIMAP similar genes for CASR using alignment to 10 protein entries:     CASR_HUMAN (see all proteins):
    GPCR    GRM8    GRM2    GRM7    GPRC6A    TAS1R1
    GRM3    GRM4    GRM5    GRM1    GRM6    TAS1R3
    TAS1R2

    CASR for paralogs           About GeneDecksing


    5/10 Pseudogenes.org Pseudogenes for CASR (see all 10)
    PGOHUM00000242293 PGOHUM00000234432 PGOHUM00000234434 PGOHUM00000234453 PGOHUM00000238241


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2521 SNPs in CASR are shown (see all 2521)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0580494
    Hypocalciuric hypercalcemia, familial 1 (HHC1)4--see VAR_0580492 G R mis40--------
    VAR_0580664
    Hypocalciuric hypercalcemia, familial 1 (HHC1)4--see VAR_0580662 G R mis40--------
    VAR_0580764
    Hypocalciuric hypercalcemia, familial 1 (HHC1)4--see VAR_0580762 V F mis40--------
    VAR_0035994
    Hypocalciuric hypercalcemia, familial 1 (HHC1)4--see VAR_0035992 R W mis40--------
    VAR_0602074
    Epilepsy, idiopathic generalized 8 (EIG8)4--see VAR_0602072 I V mis40--------
    VAR_0580824
    Familial isolated hypoparathyroidism (FIH)4--see VAR_0580822 A E mis40--------
    VAR_0580684
    Hypocalciuric hypercalcemia, familial 1 (HHC1)4--see VAR_0580682 C Y mis40--------
    VAR_0580624
    Hypocalciuric hypercalcemia, familial 1 (HHC1)4--see VAR_0580622 S F mis40--------
    VAR_0035914
    Hypocalciuric hypercalcemia, familial 1 (HHC1)4--see VAR_0035912 G E mis40--------
    VAR_0035924
    Hypocalciuric hypercalcemia, familial 1 (HHC1)4--see VAR_0035922 L R mis40--------

    HapMap Linkage Disequilibrium report for CASR (121902530 - 122005344 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CASR:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677822CNV Deletion23128226
    dgv5237n71CNV Loss21882294
    nsv877389CNV Loss21882294
    esv33139CNV Loss17666407
    nsv517368CNV Loss19592680
    nsv877387CNV Loss21882294
    nsv877390CNV Gain21882294


    Human Gene Mutation Database (HGMD): CASR

    Locus Specific Mutation Databases (LSDB): CASR
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CASR
    DNA2.0 Custom Variant and Variant Library Synthesis for CASR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601199   
    OMIM disorders: 145980  239200  146200  612899  
    UniProtKB/Swiss-Prot: CASR_HUMAN, P41180
  • Hypocalciuric hypercalcemia, familial 1 (HHC1) [MIM:145980]: A form of hypocalciuric hypercalcemia, a
    disorder of mineral homeostasis that is transmitted as an autosomal dominant trait with a high degree of
    penetrance. It is characterized biochemically by lifelong elevation of serum calcium concentrations and is
    associated with inappropriately low urinary calcium excretion and a normal or mildly elevated circulating
    parathyroid hormone level. Hypermagnesemia is typically present. Affected individuals are usually asymptomatic
    and the disorder is considered benign. However, chondrocalcinosis and pancreatitis occur in some adults. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Neonatal severe primary hyperparathyroidism (NSHPT) [MIM:239200]: Rare autosomal recessive
    life-threatening disorder characterized by very high serum calcium concentrations, skeletal demineralization, and
    parathyroid hyperplasia. In some instances NSHPT has been demonstrated to be the homozygous form of FHH. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Familial isolated hypoparathyroidism (FIH) [MIM:146200]: Characterized by hypocalcemia and
    hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps.
    An autosomal recessive form of FIH also exists. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Epilepsy, idiopathic generalized 8 (EIG8) [MIM:612899]: A disorder characterized by recurring generalized
    seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Seizure types are variable,
    but include myoclonic seizures, absence seizures, febrile seizures, complex partial seizures, and generalized
    tonic-clonic seizures. Note=Disease susceptibility is associated with variations affecting the gene represented
    in this entry
  • Note=Homozygous defects in CASR can be a cause of primary hyperparathyroidism in adulthood. Patients
    suffer from osteoporosis and renal calculi, have marked hypercalcemia and increased serum PTH concentrations

  • 20/111 diseases for CASR (see all 111):    About MalaCards
    hypercalcemia    familial hypocalciuric hypercalcemia    metastatic insulinoma    hypocalcemia, autosomal dominant
    familial hypocalciuric hypercalcemia type 1    casr-associated familial isolated hypoparathyroidism    bartter syndrome with hypocalcemia    hyperparathyroidism, neonatal severe primary
    casr-related familial isolated hypoparathyroidism    epilepsy, idiopathic generalized, susceptibility to, 8    casr-related disorders    hyperparathyroidism, neonatal
    hypocalciuric hypercalcemia, type i    hyperparathyroidism    primary hyperparathyroidism    renal osteodystrophy
    autoimmune hypoparathyroidism    hyperparathyroidism-jaw tumor syndrome    hypercalciuria, absorptive    hypoparathyroidism

    9 diseases from the University of Copenhagen DISEASES database for CASR:
    Hyperparathyroidism     Hypercalcemia     Hypoparathyroidism     Kidney disease
    Hemochromatosis     Hyperphosphatemia     Parathyroid carcinoma     Osteoporosis
    Calcinosis

    CASR for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/85 Novoseek inferred disease relationships for CASR gene (see all 85)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypocalcemia, autosomal dominant 95.9 48 15551332 (4), 11013439 (2), 17664687 (2), 11289719 (2) (see all 25)
    nshpt 95 31 17555508 (3), 9253359 (3), 9217223 (2), 9109436 (1) (see all 21)
    hyperparathyroidism secondary 90.6 38 11044218 (2), 19839774 (2), 16109139 (1), 15466262 (1) (see all 31)
    hypercalcemia 89.8 155 10468915 (5), 19694204 (3), 15241791 (3), 11857921 (3) (see all 83)
    hyperparathyroidism 87.9 79 8675635 (2), 16596260 (2), 11668634 (2), 12173690 (2) (see all 49)
    hypocalcemia 87.3 52 8813042 (3), 19915295 (3), 9920108 (2), 16596058 (2) (see all 30)
    hypoparathyroidism 86.4 75 14713274 (3), 15356052 (2), 8813042 (2), 16983178 (2) (see all 44)
    hyperparathyroidism primary 82.6 30 19520070 (4), 19567535 (2), 17853337 (1), 20164288 (1) (see all 21)
    hypercalciuria 81.9 44 17332735 (3), 12239240 (2), 15613438 (2), 8813042 (2) (see all 24)
    hyperphosphatemia 78.3 2 15490408 (1), 19580466 (1)

    Genetic Association Database (GAD): CASR
    Human Genome Epidemiology (HuGE) Navigator: CASR (81 documents)

    Export disorders for CASR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CASR gene, integrated from 9 sources (see all 783):
    (articles sorted by number of sources associating them with CASR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Blood ionized calcium is associated with clustered polymorphisms in the carboxyl-terminal tail of the calcium-sensing receptor. (PubMed id 15531522)1, 2, 4, 9 Scillitani A....Cole D.E. (2004)
    2. Genetic testing in familial isolated hyperparathyroidism: unexpected results and their implications. (PubMed id 14985373)1, 2, 4, 9 Warner J....Cardinal J. (2004)
    3. Molecular genetic analysis of the calcium sensing receptor gene in patients clinically suspected to have familial hypocalciuric hypercalcemia: phenotypic variation and mutation spectrum in a Danish population. (PubMed id 17698911)1, 2, 4, 9 Nissen P.H....Mosekilde L. (2007)
    4. Association between total serum calcium and the A986S polymorphism of the calcium-sensing receptor gene. (PubMed id 11161843)1, 2, 4, 9 Cole D.E.C....Rubin L.A. (2001)
    5. Molecular cloning of a putative Ca(2+)-sensing receptor cDNA from human kidney. (PubMed id 7677761)1, 2, 3 Aida K.... Onaya T. (1995)
    6. Familial hypocalciuric hypercalcemia associated with mutation in the human Ca(2+)-sensing receptor gene. (PubMed id 7673400)1, 2, 4 Aida K.... Onaya T. (1995)
    7. Evidence supporting a role for the calcium-sensing re ceptor in Alzheimer disease. (PubMed id 19035514)1, 4, 9 Conley Y.P....Ferrell R.E. (2009)
    8. Genetic variation in calcium-sensing receptor and risk for colon cancer. (PubMed id 18843020)1, 4, 9 Dong L.M....Peters U. (2008)
    9. Identification of a novel inactivating R465Q mutation of the calcium- sensing receptor. (PubMed id 16598859)1, 2, 9 Leech C.... Spitzweg C. (2006)
    10. Calcium-sensing receptor (CASR) mutations in hypercal cemic states: studies from a single endocrine clinic over three years. (PubMed id 20164288)1, 4, 9 Guarnieri V....Hendy G.N. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 846 HGNC: 1514 AceView: CASR Ensembl:ENSG00000036828 euGenes: HUgn846
    ECgene: CASR H-InvDB: CASR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CASR Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CASR
    SeattleSNPshttp://pga.gs.washington.edu/data/casr/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CASR gene:
    Search GeneIP for patents involving CASR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CASR
     Browse Small Molecules at EMD Millipore
     EMD Millipore Clones for the Expression of CASR
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for CASR (Calcium-sensing R/CaSR)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CASR   OriGene RNAi products in human, mouse, rat for CASR  
     OriGene qPCR primer pairs and template standards for CASR   OriGene Protein Over-expression Lysate for CASR  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CASR  
     OriGene qSTAR qPCR primer pairs in human, mouse for CASR   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CASR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CASR   OriGene Custom Protein Services for CASR  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CASR
     QIAGEN SeqTarget long-range PCR primers for resequencing CASR
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASR
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASR
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASR
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CASR
     GenScript Custom Purified and Recombinant Proteins Services for CASR GenScript cDNA clones with any tag delivered in your preferred vector for CASR
     GenScript CASR-overexpressing Cell Line for Assay GenScript Custom Superior Antibodies Services for CASR
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CASR promoter
     Search Chromatin IP Primers for CASR
     RT2 qPCR Primer Assay in human, mouse, rat CASR
     GNC Network for CASR
     SABiosciences PCR Arrays including human, mouse, rat CASR
     Tocris compounds for CASR
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CASR antibodies
     CASR proteins
     CASR lysates
     Antibodies for CASR
     See all of Abcam's Antibodies, Kits and Proteins for CASR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CASR
     Antibodies for CASR
     ELISAs for CASR
     CLIAs for CASR
     Search LifeMap BioReagents cell lines for CASR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASR
     SwitchGear 3'UTR luciferase reporter plasmids for CASR
     SwitchGear Promoter luciferase reporter plasmids for CASR
     ThermoFisher Antibody for CASR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASR
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CASR
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CASR
    Customized:
     lentivirus for stable overexpression of CASR
     lentivirus expression plasmids for stable overexpression of CASR
     adenovirus for overexpression of CASR
     LSBio Antibodies in human, mouse, rat for CASR
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CASR gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4