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CASP8AP2 Gene

protein-coding GIFtS: 60
GCID: GC06P090539

Caspase 8 Associated Protein 2

(Previous name: CASP8 associated protein 2)

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disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Caspase 8 Associated Protein 2¹ ²		CASP8-Associated Protein 2²
FLICE-Associated Huge Protein¹ ² ³		FLASH Homolog RIP25²
FLASH² ³ ⁵		FLICE Associated Huge²
CASP8 Associated Protein 2¹ ²		Human FLASH²
RIP25² ³		KIAA1315³
CED-4²

External Ids:	HGNC: 1510¹	Entrez Gene: 9994²	Ensembl: ENSG00000118412⁷	OMIM: 606880⁵	UniProtKB: Q9UKL3³

ORGUL members:

Export aliases for CASP8AP2 gene to outside databases

Previous GC identifers: GC06P090485 GC06P090535 GC06P090597 GC06P090601 GC06P087756

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CASP8AP2 Gene:

This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the

death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component

of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and

plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants

encoding the same protein.(provided by RefSeq, Nov 2008)

GeneCards Summary for CASP8AP2 Gene:

CASP8AP2 (caspase 8 associated protein 2) is a protein-coding gene. GO annotations related to this gene include death receptor binding and transcription corepressor activity.

UniProtKB/Swiss-Prot: C8AP2_HUMAN, Q9UKL3

Function: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the

nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and

NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a

TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for

the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression

through S phase

Gene Wiki entry for CASP8AP2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000006.11 NC_018917.2 NT_025741.16

Regulatory elements:

Regulatory transcription factor binding sites in the CASP8AP2 gene promoter:
Nkx5-1 Tal-1beta Roaz Arnt HNF-1A HNF-1 TGIF ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CASP8AP2 promoter sequence

Search Chromatin IP Primers for CASP8AP2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CASP8AP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q15 Ensembl cytogenetic band: 6q15 HGNC cytogenetic band: 6q15

CASP8AP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CASP8AP2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P090539: view genomic region (about GC identifiers)

Start:	90,539,613 bp from pter	End:	90,584,155 bp from pter
Size:	44,543 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: C8AP2_HUMAN, Q9UKL3 (See protein sequence)

Recommended Name: CASP8-associated protein 2

Size: 1982 amino acids; 222658 Da

Subunit: Self-associates. Component of the death-inducing signaling complex (DISC) with CASP8, FADD and FAS.

Interacts with NCOA2 and NCOA3. Interacts with SRRT. Interacts with TRAF2. Interacts with NPAT. Interacts (via

SIM domains) with SUMO1 and SUMO2. Interacts with SP100; may negatively regulate CASP8AP2 export from the nucleus

to the cytoplasm

Sequence caution: Sequence=AAH56685.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential

poly-A sequence starting in position 364; Sequence=BAA92067.1; Type=Erroneous initiation; Note=Translation

N-terminally extended;

1 PDB 3D structure from and Proteopedia for CASP8AP2:

2LR8 (3D)

Secondary accessions: A2RUB7 E1P553 Q6PH76 Q7LCQ7 Q86YD9 Q9NUQ4 Q9NZV9 Q9P2N1 Q9Y563

Explore the universe of human proteins at neXtProt for CASP8AP2: NX_Q9UKL3

Explore proteomics data for CASP8AP2 at MOPED

Post-translational modifications:

Ubiquitination² at Lys92, Lys93

Modification sites at PhosphoSitePlus

See CASP8AP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts):

NP_001131139.1 NP_001131140.1 NP_036247.1

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

1 InterPro protein domain:

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q9UKL3

ProtoNet protein and cluster: Q9UKL3

Find genes that share domains with CASP8AP2 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: C8AP2_HUMAN, Q9UKL3

Function: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the

nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and

NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a

TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for

the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression

through S phase

Induction: By TNF which induces strong nuclear localization

Gene Ontology (GO): Selected molecular function terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003714	transcription corepressor activity	IDA	12477726
GO:0005123	death receptor binding	TAS	10235259
GO:0005515	protein binding	IPI	12477726
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	ISS	--

Find genes that share ontologies with CASP8AP2 About GenesLikeMe

Phenotypes:
5 GenomeRNAi human phenotypes for CASP8AP2:

Cell division defect	Increased HPV18 LCR reporter a	Increased S DNA content, incre	Increased gamma-H2AX phosphory
S arrest

1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Casp8ap2):

mortality/aging

Find genes that share phenotypes with CASP8AP2 About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for CASP8AP2

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		hsa-miR-323-3p hsa-miR-187* hsa-miR-300 hsa-miR-1283 hsa-miR-7-2* hsa-miR-381 hsa-miR-548o hsa-miR-545

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

C8AP2_HUMAN, Q9UKL3: Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Note=Exported from the nucleus to the

mitochondria upon FAS activation

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
mitochondrion	5
nucleus	5
cytosol	2

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	12477726
GO:0005737	cytoplasm	IDA	12477726
GO:0005739	mitochondrion	IDA	17245429
GO:0016605	PML body	IDA	17245429

Find genes that share ontologies with CASP8AP2 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for CASP8AP2 About

See pathways by source

Powered
by

SuperPath

Contained pathways About

TWEAK Pathway

Apoptosis and survival TNFR1 signaling pathway

0.52

Fas Signaling

0.35

Apoptosis and survival Caspase cascade

Apoptosis and survival FAS signaling cascades

0.44

TNF-alpha/NF-kB Signaling Pathway

TNF-alpha/NF-kB Signaling Pathway

Pathways by source See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CASP8AP2

Fas Signaling

2 GeneGo (Thomson Reuters) Pathways for CASP8AP2

	Apoptosis and survival FAS signaling cascades
	Apoptosis and survival TNFR1 signaling pathway

1 BioSystems Pathway for CASP8AP2

TNF-alpha/NF-kB Signaling Pathway

Pathway & Disease-focused RT² Profiler PCR Arrays including CASP8AP2:

Apoptosis 384HT in human mouse rat

Apoptosis in human mouse rat

Necrosis in human mouse rat

Interactions:

GeneGlobe Interaction Network for CASP8AP2

Selected Interacting proteins for CASP8AP2 (Q9UKL3^{1, 2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CASP8	Q14790¹^,²^,³	EBI-2339650,EBI-78060 MINT-18006 MINT-4298716 MINT-18007 MINT-4298767 MINT-4298744 I2D: score=3
SP100	P23497¹^,²^,³	EBI-2339650,EBI-751145 MINT-4298689 MINT-4298663 MINT-4298616 MINT-4298595 MINT-4298639 I2D: score=2
FADD	Q13158²^,³	MINT-19104 I2D: score=3
CALM1	P62158³	I2D: score=1
CALM2	P62158³	I2D: score=1

About this table

Gene Ontology (GO): Selected biological process terms (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-templated	IEA	--
GO:0006355	regulation of transcription, DNA-templated	IEA	--
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISS	--
GO:0007049	cell cycle	IEA	--
GO:0007165	signal transduction	TAS	10235259

Find genes that share ontologies with CASP8AP2 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CASP8AP2 (C8AP2)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for CASP8AP2 gene (3 alternative transcripts):

NM_001137667.1 NM_001137668.1 NM_012115.3

Unigene Cluster for CASP8AP2:

Caspase 8 associated protein 2

Hs.558218 [show with all ESTs]

Unigene Representative Sequence: BC150274

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000552401(processed_transcript) ENST00000419040(processed_transcript) ENST00000547893(processed_transcript) ENST00000237177(processed_transcript) ENST00000548224(processed_transcript)

ENST00000551025(processed_transcript) ENST00000444163(processed_transcript)

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		hsa-miR-323-3p hsa-miR-187* hsa-miR-300 hsa-miR-1283 hsa-miR-7-2* hsa-miR-381 hsa-miR-548o hsa-miR-545

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Additional mRNA sequence:

AB037736.2 AF154415.1 AF164678.2 AF165161.1 AJ420582.1 AK002070.1 BC012574.1 BC027850.1

BC029386.1 BC042577.1 BC056685.1 BC132828.1 BC132830.1 BC150274.1

8 DOTS entries:

DT.109577 DT.97782666 DT.101980468 DT.427892 DT.100699484 DT.121359284 DT.121614134 DT.91865531

Selected AceView cDNA sequences (see all 98):

AW294409 AL603075 AL700551 BU681813 AA765960 AW612479 BM874653 BP363682

BM854732 AI887718 BU159683 AU138126 AI591001 BX503336 BM970205 AW440936

AL704321 CA430521 BC012574 BM714281 BP335969 N51265 BQ022238 BU076158

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CASP8AP2 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10
SP1:			-
SP2:
SP3:
SP4:

ECgene alternative splicing isoforms for CASP8AP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CASP8AP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TAAAGTTTTG

About this image

CASP8AP2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CASP8AP2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.558218

Pathway & Disease-focused RT² Profiler PCR Arrays including CASP8AP2:

Apoptosis 384HT in human mouse rat

Apoptosis in human mouse rat

Necrosis in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CASP8AP2 gene from Selected species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Casp8ap2^{1 , 5}	caspase 8 associated protein 2^{1, 5}	77.89(n)¹ 67.06(a)¹		4 (14.27 cM)⁵ 26885¹ NM_001122978.1¹ NP_001116450.1¹ 32615451⁵
tropical clawed frog (Xenopus tropicalis)	Amphibia	AL900866.2²	--	76.54(n)		AL900866.2

ENSEMBL Gene Tree for CASP8AP2 (if available)
TreeFam Gene Tree for CASP8AP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11758969^1,2	C,F,A,H	--	87755140(+)	`aaaatG/Taaaga`	3	--	us2k¹		4		NA WA	242
rs181965725^1,2	C	--	87755154(+)	`AAAGGC/TGAGTG`	3	--	us2k¹		0	--	--	--	--
rs149786170^1,2	C	--	87755290(+)	`GAGACA/CTTGTC`	3	--	us2k¹		0	--	--	--	--
rs202142963^1,2		--	87755298(+)	`TCTCT-/AAAAAA`	3	--	us2k¹		0	--	--	--	--
rs118191252^1,2	C	--	87755325(+)	`CCAGGC/TGCGGT`	3	--	us2k¹		1		EA	120
rs11969854^1,2	C,H	--	87755365(+)	`aaagcC/Tgaggc`	3	--	us2k¹		0	--	--	--	--
rs187610901^1,2		--	87755492(+)	`GGAGGC/TTGAGG`	3	--	us2k¹		0	--	--	--	--
rs144377184^1,2		--	87755579(+)	`CAAGAA/GTGAAA`	3	--	us2k¹		0	--	--	--	--
rs35575202^1,2	C	--	87755594(+)	`GTCTC-/AAAAAA`	3	--	us2k¹		0	--	--	--	--
rs146642066^1,2		--	87755631(+)	`AAATTG/TGTTGA`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CASP8AP2 (90539613 - 90584155 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for CASP8AP2: About this table

Variant ID	Type	Subtype	PubMed ID
esv2732412	CNV	Deletion	23290073
nsv512888	CNV	Insertion	21212237
nsv5391	CNV	Insertion	18451855
esv997597	CNV	Insertion	20482838
nsv886340	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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OMIM gene information: 606880 OMIM disorders: --

Find genes that share disorders with CASP8AP2 About GenesLikeMe

Genetic Association Database (GAD): CASP8AP2
Human Genome Epidemiology (HuGE) Navigator: CASP8AP2 (5 documents)

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CASP8AP2 gene, integrated from 10 sources (see all 63):
(articles sorted by number of sources associating them with CASP8AP2)

FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies. (PubMed id 17245429)^{1, 2, 3, 9} Milovic-Holm K.... Hofmann T.G. (EMBO J. 2007)
FLASH is required for histone transcription and S-phase progression. (PubMed id 17003125)^{1, 2, 9} Barcaroli D.... De Laurenzi V. (Proc. Natl. Acad. Sci. U.S.A. 2006)
FLASH is an essential component of Cajal bodies. (PubMed id 17003126)^{1, 3, 9} Barcaroli D....De Laurenzi V. (Proc. Natl. Acad. Sci. U.S.A. 2006)
PolySUMO-binding proteins identified through a string search. (PubMed id 23086935)^{1, 2} Sun H. and Hunter T. (J. Biol. Chem. 2012)
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)^{1, 4} Hosgood H.D....Lan Q. (Occup Environ Med 2009)
Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies. (PubMed id 19414860)^{1, 4} Lan Q....Wang S.S. (Blood 2009)
Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase. (PubMed id 19546234)^{1, 2} Kiriyama M.... Yonehara S. (Mol. Cell. Biol. 2009)
Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)^{1, 4} Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
Mutational analysis of FLASH and PTPN13 genes in colorectal carcinomas. (PubMed id 18038312)^{1, 4} Jeong E.G....Lee S.H. (Pathology 2008)
Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)^{1, 2} Denis N.J.... Figeys D. (Proteomics 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9994	HGNC: 1510	AceView: CASP8AP2	Ensembl:ENSG00000118412	euGenes: HUgn9994
ECgene: CASP8AP2	H-InvDB: CASP8AP2

(According to HUGE)
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HUGE: KIAA1315

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CASP8AP2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CASP8AP2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CASP8AP2 gene
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CASP8AP2 Gene

Caspase 8 Associated Protein 2

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CASP8AP2 Gene

Caspase 8 Associated Protein 2

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