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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CASP8AP2 Gene

protein-coding   GIFtS: 56
GCID: GC06P090539

caspase 8 associated protein 2

(Previous name: CASP8 associated protein 2 )
 Explore 11 diseases affiliated with
CASP8AP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CASP8AP2    

Aliases
for CASP8AP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Caspase 8 Associated Protein 21 2     FLICE-Associated Huge Protein2 3
FLASH1 2 3 5     FLJ112081
RIP251 2 3     CASP8-Associated Protein 22
CED-41 2     FLASH Homolog RIP252
CASP8 Associated Protein 21 2     FLICE Associated Huge2
KIAA13151 3     Human FLASH2

External Ids:    HGNC: 15101   Entrez Gene: 99942   Ensembl: ENSG000001184127   OMIM: 6068805   UniProtKB: Q9UKL33   

Export aliases for CASP8AP2 gene to outside databases

Previous GC identifers: GC06P090485 GC06P090535 GC06P090597 GC06P090601 GC06P087756


Summaries
for CASP8AP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CASP8AP2:
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the
death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of
the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a
regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the
same protein.(provided by RefSeq, Nov 2008)

UniProtKB/Swiss-Prot: C8AP2_HUMAN, Q9UKL3
Function: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear
receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced
enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent
pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of
CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase

Gene Wiki entry for CASP8AP2


Genomic Views
for CASP8AP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007299.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CASP8AP2 gene promoter:
         Nkx5-1   Tal-1beta   Roaz   Arnt   HNF-1A   HNF-1   TGIF   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CASP8AP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CASP8AP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASP8AP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q15   Ensembl cytogenetic band:  6q15   HGNC cytogenetic band: 6q15

CASP8AP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CASP8AP2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P090539:  view genomic region     (about GC identifiers)

Start:
 90,539,613 bp from pter      End:
 90,584,155 bp from pter
Size:
 44,543 bases      Orientation:
 plus strand

Proteins
for CASP8AP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: C8AP2_HUMAN, Q9UKL3 (See protein sequence)
Recommended Name: CASP8-associated protein 2  
Size: 1982 amino acids; 222658 Da
Subunit: Self-associates. Component of the death-inducing signaling complex (DISC) with CASP8, FADD and FAS. Interacts
with NCOA2, NCOA3, SRRT/ARS2 and TRAF2. Interacts with NPAT. Interacts (via SIM domains) with SUMO1 and SUMO2
Subcellular location: Cytoplasm. Nucleus. Note=Localizes to discrete nuclear foci
Sequence caution: Sequence=AAH56685.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence starting in position 364; Sequence=BAA92067.1; Type=Erroneous initiation; Note=Translation N-terminally
extended;
1 PDB 3D structure from and Proteopedia for CASP8AP2:
2LR8 (3D)    
Secondary accessions: A2RUB7 E1P553 Q6PH76 Q7LCQ7 Q86YD9 Q9NUQ4 Q9NZV9 Q9P2N1 Q9Y563

Explore the universe of human proteins at neXtProt for CASP8AP2: NX_Q9UKL3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UKL3

    • CASP8AP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001131139.1  NP_001131140.1  NP_036247.1  

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    Uscn Proteins for CASP8AP2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12477726
    GO:0005737cytoplasm IDA12477726


    CASP8AP2 for ontologies           About GeneDecksing



    CASP8AP2 Antibody Products: 
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    Uscn ELISAs and CLIAs for CASP8AP2

    Protein Domains /
    Families
    for CASP8AP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CASP8AP2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9UKL3

    ProtoNet protein and cluster: Q9UKL3


    Function
    for CASP8AP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: C8AP2_HUMAN, Q9UKL3
    Function: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear
    receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced
    enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent
    pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of
    CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase
    Induction: By TNF which induces strong nuclear localization

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CASP8AP2 (see all 14):
    hsa-miR-323-3p hsa-miR-187* hsa-miR-300 hsa-miR-1283 hsa-miR-7-2* hsa-miR-381 hsa-miR-548o hsa-miR-545
    SwitchGear 3'UTR luciferase reporter plasmid: CASP8AP2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity IDA12477726
    GO:0005123death receptor binding TAS10235259
    GO:0005515protein binding IPI--
    GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process ISS--


    CASP8AP2 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for CASP8AP2:
     Cell division defect  Increased HPV18 LCR reporter a  Increased S DNA content, incre  Increased gamma-H2AX phosphory 
     S arrest 

    Animal Models:
         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Casp8ap2):
     mortality/aging 

    CASP8AP2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CASP8AP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TWEAK Pathway
    		Apoptosis and survival_TNFR1 signaling pathway0.40
    		Fas Signaling0.29
    		Apoptosis and survival TNFR1 signaling pathway0.40
    2Apoptosis and survival_Caspase cascade
    		Apoptosis and survival_FAS signaling cascades0.44
    		Apoptosis and survival FAS signaling cascades0.44
    3TNF-alpha/NF-kB Signaling Pathway
    		TNF-alpha/NF-kB Signaling Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for CASP8AP2
        Apoptosis and survival TNFR1 signaling pathway
    Apoptosis and survival FAS signaling cascades

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CASP8AP2
        Fas Signaling

    2 GeneGo (Thomson Reuters) Pathways for CASP8AP2
        Apoptosis and survival FAS signaling cascades
    Apoptosis and survival TNFR1 signaling pathway

    1 BioSystems Pathway for CASP8AP2 
        TNF-alpha/NF-kB Signaling Pathway



    CASP8AP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CASP8AP2

    5/16 Interacting proteins for CASP8AP2 (Q9UKL31, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP8Q147902, 3MINT-18006 MINT-4298716 MINT-18007 MINT-4298767 MINT-4298744 I2D: score=3 
    SP100P234972, 3MINT-4298689 MINT-4298663 MINT-4298616 MINT-4298595 MINT-4298639 I2D: score=2 
    FADDQ131582, 3MINT-19104 I2D: score=3 
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process ISS--
    GO:0007049cell cycle IEA--
    GO:0007165signal transduction TAS10235259


    CASP8AP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CASP8AP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CASP8AP2
    Search CenterWatch for drugs/clinical trials and news about CASP8AP2 / C8AP2 

    Transcripts
    for CASP8AP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CASP8AP2 gene (3 alternative transcripts): 
    NM_001137667.1  NM_001137668.1  NM_012115.3  

    Unigene Cluster for CASP8AP2:

    Caspase 8 associated protein 2
    Hs.558218  [show with all ESTs]
    Unigene Representative Sequence: BC150274
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552401 ENST00000419040 ENST00000547893 ENST00000237177(uc003pnr.3 uc003pnt.3 uc011dzz.2)
    ENST00000548224 ENST00000551025(uc003pns.2) ENST00000444163

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CASP8AP2
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CASP8AP2 (see all 14):
    hsa-miR-323-3p hsa-miR-187* hsa-miR-300 hsa-miR-1283 hsa-miR-7-2* hsa-miR-381 hsa-miR-548o hsa-miR-545
    SwitchGear 3'UTR luciferase reporter plasmid: CASP8AP2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CASP8AP2 (see all 7)
    OriGene shRNA RFP: CASP8AP2
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    Clone
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    Additional cDNA sequence: 

    AB037736.2 AF154415.1 AF164678.2 AF165161.1 AJ420582.1 AK002070.1 BC012574.1 BC027850.1 
    BC029386.1 BC042577.1 BC056685.1 BC132828.1 BC132830.1 BC150274.1 

    8 DOTS entries:

    DT.109577  DT.97782666  DT.101980468  DT.427892  DT.100699484  DT.121359284  DT.121614134  DT.91865531 

    24/98 AceView cDNA sequences (see all 98):

    BU076158 BM970205 N51265 AI887718 AW612479 AA765960 AW440936 BU681813 
    AU138126 AI591001 BM714281 CA430521 BM874653 AL704321 BC012574 BQ022238 
    BX503336 AL700551 BU159683 BP335969 BP363682 BM854732 AW294409 AL603075 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CASP8AP2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:        -                                                         
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for CASP8AP2

    Expression
    for CASP8AP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CASP8AP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAAGTTTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CASP8AP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungLung BudLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CASP8AP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CASP8AP2

    SOURCE GeneReport for Unigene cluster: Hs.558218
        SABiosciences Expression via Pathway-Focused PCR Arrays including CASP8AP2: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat
              Necrosis in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for CASP8AP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CASP8AP2 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Casp8ap21 , 5 caspase 8 associated protein 21, 5 78.07(n)1
    67.31(a)1    		   4 (14.27 cM)5
    268851  NM_001122978.11  NP_001116450.11 
     326154515 
    chicken
    (Gallus gallus)    		 Aves CASP8AP21 caspase 8 associated protein 2 57.82(n)
    44.56(a)    		   421810  XM_419834.2  XP_419834.2 
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia AL900866.22   -- 76.54(n)    AL900866.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii casp8ap21 CASP8 associated protein 2 44.38(n)
    33.15(a)    		   541521  NM_001014334.2  NP_001014356.2 


    ENSEMBL Gene Tree for CASP8AP2 (if available)
    TreeFam Gene Tree for CASP8AP2 (if available) 

    Paralogs
    for CASP8AP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CASP8AP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/18 NCBI SNPs in CASP8AP2 are shown (see all 18)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs346765061,2
    		C,--90552587(+) AAAAAC/-AAAAA 3 -- int11Minor allele frequency- -:0.00NA 2
    rs1118849461,2
    		C,--90554914(+) ACAGGC/TGTGAG 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1837846131,2
    		--90554924(+) GCCACC/GGCACC 1 -- int10--------
    rs1449602111,2
    		--90555123(+) TCACCC/TGAGGA 1 -- int10--------
    rs1410674591,2
    		--90558554(+) TCTAT-/ACACACA
    CACACACAC    ACACA     		3 -- int10--------
    rs1428152541,2
    		--90567427(+) TCACTA/TGAGCT 1 -- int10--------
    rs1121474251,2
    		--90574876(+) AAAACC/TAATGA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1410431031,2
    		--90574888(+) ACAGGC/TGGGGC 1 -- int10--------
    rs1468355661,2
    		--90581936(+) TACAGA/GCGTGA 1 -- int10--------
    rs93626931,2
    		----90554964(+) TTAATG/ATGTGT 1 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for CASP8AP2 (90539613 - 90584155 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CASP8AP2
         1 CNV: 36581

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    Disorders / Diseases
    for CASP8AP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CASP8AP2 for disorders           About GeneDecksing

    OMIM gene information: 606880    OMIM disorders: --

    11 diseases for CASP8AP2:    About MalaCards
    non-hodgkin lymphoma    glucocorticoid resistance    hodgkin's lymphoma    acute lymphoblastic leukemia
    lymphoblastic leukemia    hepatitis b    leukemia    prostate cancer
    hepatitis    prostatitis    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: CASP8AP2 (5 documents)

    Export disorders for CASP8AP2 gene to outside databases

    Publications
    for CASP8AP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CASP8AP2 gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with CASP8AP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies. (PubMed id 17245429)1, 3, 9 Milovic-Holm K....Hofmann T.G. (2007)
    2. FLASH is required for histone transcription and S-phase progression. (PubMed id 17003125)1, 2, 9 Barcaroli D.... De Laurenzi V. (2006)
    3. FLASH is an essential component of Cajal bodies. (PubMed id 17003126)1, 3, 9 Barcaroli D....De Laurenzi V. (2006)
    4. Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase. (PubMed id 19546234)1, 2 Kiriyama M.... Yonehara S. (2009)
    5. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    6. FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors. (PubMed id 15698540)1, 2 Kino T.... Chrousos G.P. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators. (PubMed id 12477726)1, 2 Kino T. and Chrousos G.P. (2003)
    10. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)

    External Searches for CASP8AP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
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    Genome Databases showing CASP8AP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9994 HGNC: 1510 AceView: CASP8AP2 Ensembl:ENSG00000118412 euGenes: HUgn9994
    ECgene: CASP8AP2 H-InvDB: CASP8AP2

    Other Databases showing CASP8AP2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1315

    Specialized Databases showing CASP8AP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CASP8AP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CASP8AP2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CASP8AP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CASP8AP2 gene:
    Search GeneIP for patents involving CASP8AP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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