Aliases for CASP8AP2 Gene
External Ids for CASP8AP2 Gene
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008]
GeneCards Summary for CASP8AP2 Gene
CASP8AP2 (Caspase 8 Associated Protein 2) is a Protein Coding gene. Among its related pathways are TWEAK Pathway and TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include transcription corepressor activity and death receptor binding.
UniProtKB/Swiss-Prot for CASP8AP2 Gene
Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.