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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CASP7 Gene

protein-coding   GIFtS: 69
GCID: GC10P115428

caspase 7, apoptosis-related cysteine peptidase

(Previous names: caspase 7, apoptosis-related cysteine protease )
 Explore 75 diseases affiliated with
CASP7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CASP7    

Aliases
for CASP7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Caspase 7, Apoptosis-Related Cysteine Peptidase1 2     CASP-72 3
MCH31 2 3 5     ICE-Like Apoptotic Protease 32 3
CMH-11 2 3     LICE22
ICE-LAP31 2 3     Caspase-71
Caspase 7, Apoptosis-Related Cysteine Protease1 2     EC 3.4.22.603
Apoptotic Protease Mch-32 3     EC 3.4.228

External Ids:    HGNC: 15081   Entrez Gene: 8402   Ensembl: ENSG000001658067   OMIM: 6017615   UniProtKB: P552103   

Export aliases for CASP7 gene to outside databases

Previous GC identifers: GC10P114346 GC10P114672 GC10P115570 GC10P115103 GC10P109065


Summaries
for CASP7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CASP7:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases
plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo
proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form
the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death
stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed
for this gene. (provided by RefSeq, May 2012)

UniProtKB/Swiss-Prot: CASP7_HUMAN, P55210
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates
sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a
'216-Asp- -Gly-217' bond. Overexpression promotes programmed cell death

summary for CASP7:
Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of
apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and
effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with,
upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector
caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the
executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase
Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors
such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For
example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form
part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by
inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of
many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory
disease.

Gene Wiki entry for CASP7 (Caspase 7)


Genomic Views
for CASP7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CASP7 gene promoter:
         MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CASP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CASP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q25

CASP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CASP7 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P115428:  view genomic region     (about GC identifiers)

Start:
 115,438,935 bp from pter      End:
 115,490,664 bp from pter
Size:
 51,730 bases      Orientation:
 plus strand

Proteins
for CASP7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CASP7_HUMAN, P55210 (See protein sequence)
Recommended Name: Caspase-7 precursor  
Size: 303 amino acids; 34277 Da
Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and
a 11 kDa (p11) subunit. Interacts with BIRC6/bruce
Subcellular location: Cytoplasm
6/23 PDB 3D structures from and Proteopedia for CASP7 (see all 23):
1F1J (3D)        1GQF (3D)        1I4O (3D)        1I51 (3D)        1K86 (3D)        1K88 (3D)    
Secondary accessions: B4DQU7 B5BU45 D3DRB8 Q13364 Q53YD5 Q5SVL0 Q5SVL3 Q96BA0
Alternative splicing: 4 isoforms:  P55210-1   P55210-2   P55210-3   P55210-4   (What we call isoform Alpha' is also known as Beta (PubMed:9070923))

Explore the universe of human proteins at neXtProt for CASP7: NX_P55210

Post-translational modifications:

  • Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved
    • efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of
    caspase-3, and vice versa, also occur1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55210

    • 4 DME Specific Peptides for CASP7 (P55210)
     PGYYSWR  CIIINNKNF  IQACRGTELD  KPKLFFIQAC 

    CASP7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (7 alternative transcripts): 
    NP_001218.1  NP_001253985.1  NP_001253986.1  NP_001253987.1  NP_203124.1  NP_203125.1  NP_203126.1  

    ENSEMBL proteins: 
     ENSP00000400094   ENSP00000358337   ENSP00000298701   ENSP00000358324   ENSP00000358322  
     ENSP00000358321   ENSP00000358327   ENSP00000398107  
    Reactome Protein details: P55210
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CASP7 (Caspase-7)
    Enzo Life Sciences proteins for CASP7
    OriGene Purified Proteins (see all 2): CASP7
    OriGene Protein Over-expression Lysate (see all 6): CASP7
    OriGene Custom Protein Services for CASP7 
    GenScript Custom Purified and Recombinant Proteins Services for CASP7
    Novus Biologicals CASP7 Proteins
    Novus Biologicals CASP7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CASP7

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005634nucleus IDA17167422
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS8576161
    GO:0005789endoplasmic reticulum membrane ----


    CASP7 for ontologies           About GeneDecksing



    CASP7 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CASP7
    R&D Systems Antibodies for CASP7 (Caspase-7)
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    Novus Biologicals CASP7 Antibodies
    Abcam antibodies for CASP7 
    Uscn Antibodies for CASP7
    ThermoFisher Antibody for CASP7

    Assay Products for CASP7: 
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    OriGene Custom Immunoassay Development
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    GenScript CASP7-Activity-based Protease Assay for Compound Screening
    Enzo Life Sciences assays for CASP7
    Uscn ELISAs and CLIAs for CASP7

    Protein Domains /
    Families
    for CASP7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CASP7 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR001309 Pept_C14_ICE_p20
     IPR015471 Casp7
     IPR002138 Pept_C14_p10
     IPR015917 Pept_C14_p45_core
     IPR011600 Pept_C14_cat

    Graphical View of Domain Structure for InterPro Entry P55210

    ProtoNet protein and cluster: P55210

    2 Blocks protein families:
    IPB001309 Caspase-1
    IPB002398 Interleukin-1B converting enzyme signature


    UniProtKB/Swiss-Prot: CASP7_HUMAN, P55210
    Similarity: Belongs to the peptidase C14A family


    Function
    for CASP7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CASP7_HUMAN, P55210
    Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates
    sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a
    '216-Asp- -Gly-217' bond. Overexpression promotes programmed cell death
    Catalytic activity: Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of
    Asp-Glu-Val-Asp- -
    Enzyme regulation: Inhibited by isatin sulfonamides

         Genatlas biochemistry entry for CASP7:
    caspase 7,effector,cysteine containing aspartate-specific protease,CASP3 subfamily,stored in the mitochondrial
    intermembrane space and released into cytosol after appropriate apoptotic stimuli,promoting apoptosis,H3,isoform
    alpha,interacting with calpain during B cell clonal deletion by apoptosis

    Enzyme Numbers (IUBMB): EC 3.4.222 EC 3.4.22.601

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CASP7
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate CASP7 (see all 27):
    hsa-miR-3673 hsa-miR-106a hsa-miR-29a hsa-miR-29c hsa-miR-507 hsa-miR-570 hsa-miR-93 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmid: CASP7 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CASP7 (see all 7)
    OriGene shRNA RFP: CASP7
    OriGene siRNA: CASP7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASP7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CASP7

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CASP7 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CASP7 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): CASP7 (NM_033340)
    Sino Biological Human cDNA Clone for CASP7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASP7 

    Cell Line
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    Search LifeMap BioReagents cell lines for CASP7

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP7

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004190aspartic-type endopeptidase activity IEA--
    GO:0004197cysteine-type endopeptidase activity TAS--
    GO:0005515protein binding IPI--
    GO:0008233peptidase activity ----
    GO:0008234cysteine-type peptidase activity TAS8567622


    CASP7 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for CASP7: Casp7tm1.1Acau Casp7tm1Flv
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Casp7):
     cardiovascular system  cellular  hematopoietic system  immune system  mortality/aging 
     nervous system  vision/eye 

    CASP7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CASP7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/37 super-pathways (see all 37) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TWEAK Pathway
    8/13 pathways (see all 13)
    		TWEAK Pathway1.00
    		TNF Signaling0.40
    		DR3 Signaling0.87
    		Apoptotic Pathways Triggered By HIV10.37
    		TNFR1 Pathway0.53
    		Apoptosis through Death Receptors0.32
    		GITR Pathway0.46
    		TWEAK Signaling Pathway0.31
    2Apoptosis and survival_Caspase cascade
    		Apoptosis and survival_Caspase cascade1.00
    		Apoptosis and survival FAS signaling cascades0.44
    		Apoptosis and survival Caspase cascade1.00
    		Caspase cascade in apoptosis0.42
    		Apoptosis and survival_FAS signaling cascades0.44
    		FAS pathway and Stress induction of HSP regulation0.33
    3Apoptotic factor-mediated response
    		Apoptotic factor-mediated response1.00
    		SMAC-mediated apoptotic response0.71
    		Activation of caspases through apoptosome-mediated cleavage0.71
    		SMAC binds to IAPs 0.71
    		Cytochrome c-mediated apoptotic response0.71
    		SMAC-mediated dissociation of IAP:caspase complexes 0.71
    4Apoptotic cleavage of cellular proteins
    		Apoptotic cleavage of cellular proteins1.00
    		Caspase-mediated cleavage of cytoskeletal proteins0.32
    		Apoptotic execution phase0.73
    5Apoptosis and survival_Lymphotoxin-beta receptor signaling
    		Apoptosis and survival Lymphotoxin-beta receptor signaling1.00
    		LT-BetaR Pathway0.46
    		Apoptosis and survival_Lymphotoxin-beta receptor signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/6 EMD Millipore Pathways for CASP7 (see all 6)
        Apoptosis and survival TNFR1 signaling pathway
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Lymphotoxin-beta receptor signaling

    1 R&D Systems Pathway for CASP7
        Apoptosis Signaling Pathways

    5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CASP7 (see all 27)
        Caspase Cascade
    TWEAK Pathway
    14-3-3 Induced Apoptosis
    DHA Signaling
    LT-BetaR Pathway

    1 Cell Signaling Technology (CST) Pathway for CASP7
        Apoptosis and Autophagy

    2 Tocris Bioscience Pathways for CASP7
        Apoptosis Pathway
    VEGF Pathway

    5 GeneGo (Thomson Reuters) Pathways for CASP7
        Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Apoptosis and survival Lymphotoxin-beta receptor signaling
    Apoptosis and survival TNFR1 signaling pathway

    5/18 BioSystems Pathways for CASP7 (see all 18) 
        MAPK signaling pathway
    FAS pathway and Stress induction of HSP regulation
    NOD pathway
    Oncostatin M Signaling Pathway
    Parkinsons Disease Pathway

    5/11        Reactome Pathways for CASP7 (see all 11)
        Apoptotic execution phase
    Caspase-mediated cleavage of cytoskeletal proteins
    Apoptotic factor-mediated response
    SMAC-mediated apoptotic response
    Apoptosis


    3         Kegg Pathways  (Kegg details for CASP7):
        Apoptosis
    Alzheimer's disease
    Pertussis


    CASP7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CASP7

    5/93 Interacting proteins for CASP7 (P552101, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001836release of cytochrome c from mitochondria IEA--
    GO:0006508proteolysis IDA12888622
    GO:0006915apoptotic process TAS--
    GO:0006917induction of apoptosis IEA--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--


    CASP7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CASP7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CASP7 for compounds           About GeneDecksing

    EMD Millipore small molecules for CASP7:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for CASP7

    Compounds for CASP7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Ac-LEHD-AFCFluorogenic caspase substrate[210345-03-2]
    Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor --

    1 DrugBank Compound for CASP7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Fica-- --target--17139284 17016423 10592235

    10/59 Novoseek chemical compound relationships for CASP7 gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adpribose 65.8 14 11403964 (2), 14679006 (1), 11720482 (1), 18806828 (1) (see all 12)
    mevastatin 47.7 2 15385411 (1), 16427097 (1)
    ceramide 47.6 7 17893663 (1), 16170023 (1), 16359673 (1), 15255262 (1) (see all 6)
    paclitaxel 46.1 8 19674193 (2), 17854074 (1), 11278107 (1), 15700118 (1) (see all 6)
    cisplatin 44.9 29 20034524 (2), 19111676 (2), 17922809 (1), 10194341 (1) (see all 11)
    cd 437 44.8 2 11156424 (2)
    polyadenosine diphosphate ribose 43.6 3 12828737 (1), 10510942 (1)
    etoposide 41.2 8 12665508 (2), 17941090 (1), 19426747 (1), 18403493 (1) (see all 6)
    phosphatidylserine 39.7 10 17707271 (2), 20441051 (1), 16192639 (1), 19357081 (1) (see all 8)
    rottlerin 39.4 1 18413747 (1)

    Search CenterWatch for drugs/clinical trials and news about CASP7 

    Transcripts
    for CASP7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CASP7 gene (7 alternative transcripts): 
    NM_001227.4  NM_001267056.1  NM_001267057.1  NM_001267058.1  NM_033338.5  NM_033339.4  NM_033340.3  

    Unigene Cluster for CASP7:

    Caspase 7, apoptosis-related cysteine peptidase
    Hs.9216  [show with all ESTs]
    Unigene Representative Sequence: NM_033338
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429617 ENST00000369331(uc001lam.3 uc001lan.3) ENST00000345633
    ENST00000369318(uc010qsb.2) ENST00000369316 ENST00000369315 ENST00000468790
    ENST00000487232 ENST00000369321(uc001lao.3 uc001lap.3 uc001laq.3 uc010qsa.2)
    ENST00000452490

    miRNA
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    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate CASP7 (see all 27):
    hsa-miR-3673 hsa-miR-106a hsa-miR-29a hsa-miR-29c hsa-miR-507 hsa-miR-570 hsa-miR-93 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmid: CASP7 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CASP7 (see all 7)
    OriGene shRNA RFP: CASP7
    OriGene siRNA: CASP7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASP7
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CASP7 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CASP7 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): CASP7 (NM_033340)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASP7 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASP7

    Additional cDNA sequence: 

    AB451281.1 AB451413.1 AK223489.1 AK298964.1 AK300578.1 AK301437.1 BC015799.1 BT006683.1 
    BX647973.1 U37448.1 U37449.1 U39613.1 U40281.1 U67206.1 U67320.1 

    11 DOTS entries:

    DT.415134  DT.91711171  DT.100792238  DT.121261395  DT.95166647  DT.422074  DT.100691275  DT.121261310 
    DT.97841342  DT.100712135  DT.121261296 

    24/143 AceView cDNA sequences (see all 143):

    BU619208 AA296944 BU197358 CD366838 AU117167 U37449 U37448 CR591113 
    BE644891 BM976488 BQ008163 CB045242 AA983777 BU632085 NM_033340 AA890033 
    AU130224 AW132025 BU628094 AA297274 AA863347 BQ007179 AA782107 AW028999 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CASP7 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c
    SP1:              -     -     -     -     -     -     -           -     -     -     -                                   -                                 
    SP2:                                            -                 -     -     -     -                                         -                           
    SP3:                                                              -     -     -     -                                         -                           
    SP4:              -     -     -     -     -     -     -           -     -     -     -                                         -                           
    SP5:                                            -     -           -     -     -     -                                         -                           


    ECgene alternative splicing isoforms for CASP7

    Expression
    for CASP7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CASP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAAGAACAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CASP7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMononuclear MyocytesSkeletal Muscle
    BrainChoroid PlexusBrain
    Neural TubeDiencephalic Roof PlateNeural Tube
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CASP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CASP7

    SOURCE GeneReport for Unigene cluster: Hs.9216

    UniProtKB/Swiss-Prot: CASP7_HUMAN, P55210
    Tissue specificity: Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in
    testis. No expression in the brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including CASP7 (see all 8): 
              Parkinson's Disease in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Apoptosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Neurotoxicity in human mouse rat

    Primer
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    Assay Products:     
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    Orthologs
    for CASP7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CASP7 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CASP71 caspase 7, apoptosis-related cysteine peptidase 68.33(n)
    73(a)    		   423901  XM_421764.2  XP_421764.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CASP76
    		 --
    		 63(a)
    		 1 ↔ 1
    		 GL343204.1(604427-610931)
    African clawed frog
    (Xenopus laevis)    		 Amphibia xCaspase-72 caspase-7 75.89(n)    AB038170.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii casp71 caspase 7, apoptosis-related cysteine peptidase 65.98(n)
    68.49(a)    		   553634  NM_001020607.1  NP_001018443.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Dcp-11 , 3 apoptosis effector caspase3
    Death caspase-11    		 44(a)
    (best of 3)3
    51.6(n)1
    46.44(a)1    		   59E33
    377291  NM_057626.31  NP_476974.11 


    ENSEMBL Gene Tree for CASP7 (if available)
    TreeFam Gene Tree for CASP7 (if available) 

    Paralogs
    for CASP7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CASP7 gene
    CASP162  CASP62  CASP82  CASP122  CASP92  CASP32  CASP22  CASP142  
    CASP12  CASP52  CASP102  CASP42  
    18/29 SIMAP similar genes for CASP7 using alignment to 3 protein entries:     CASP7_HUMAN (see all proteins) (see all similar genes):
    NF2    HMGA2    C16orf89    TIGD1L2    FAM138A    FAM138B
    FAM138C    FAM138F    FLJ20555    KIAA1651    MYB    SHANK2
    FAM175A    FAM138D    PKN1    TMEM135    DNAPTP3    CASP3

    CASP7 for paralogs           About GeneDecksing



    Genomic Variants
    for CASP7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/986 NCBI SNPs in CASP7 are shown (see all 986)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1389120431,2
    		--115437158(+) TGTTGC/TGGGTG 2 -- us2k10--------
    rs1833336731,2
    		--115437266(+) ACTAAC/GCTGCA 2 -- us2k10--------
    rs111964171,2
    		H--115437340(+) TGATTC/ATACTT 2 -- us2k14Minor allele frequency- A:0.00NS EA 414
    rs1882188801,2
    		--115437371(+) ACGGGA/GGCAAC 2 -- us2k10--------
    rs1921037231,2
    		--115437380(+) ACTTCA/GCTGAG 2 -- us2k10--------
    rs1143044681,2
    		F,--115437475(+) ACCTGC/AAAGAT 6 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1832232741,2
    		--115437654(+) GCTCAC/TTGCAA 6 -- us2k10--------
    rs127637871,2
    		C,--115437703(+) CCTCCT/CGAGTA 6 -- us2k12Minor allele frequency- C:0.00NA CSA 3
    rs342156721,2
    		C,--115437746(+) GCTAA-/TTTTTT 6 -- us2k12Minor allele frequency- T:0.25NA CSA 4
    rs358870321,2
    		C--115437772(+) GACAGG/AGTTTC 6 -- us2k11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for CASP7 (115438935 - 115490664 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CASP7: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for CASP7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CASP7 for disorders           About GeneDecksing

    OMIM gene information: 601761    OMIM disorders: --

    20/75 diseases for CASP7 (see all 75):    About MalaCards
    synovitis    adenomatous polyposis coli    traumatic brain injury    non-hodgkin lymphoma
    gastrointestinal stromal tumor    brain injury    oral squamous cell carcinoma    squamous cell carcinoma
    hodgkin's lymphoma    rheumatoid arthritis    neurodegenerative disease    chronic myeloid leukemia
    gastrointestinal lymphoma    werner syndrome    myeloid leukemia    carcinoma
    kaposi's sarcoma    malignant glioma    fibrosarcoma    renal cell carcinoma

    10/32 Novoseek disease relationships for CASP7 gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 53.9 13 17234160 (1), 19117056 (1), 16552962 (1), 19846905 (1) (see all 9)
    necrosis 53 18 18980241 (1), 15204708 (1), 19306923 (1), 11755217 (1) (see all 16)
    tumors 51 23 11403964 (2), 16609042 (1), 16452233 (1), 18806828 (1) (see all 20)
    breast cancer 48.7 9 19009586 (1), 16430140 (1), 20348950 (1), 15283467 (1) (see all 7)
    colon cancer 42.1 8 11381362 (3), 12907606 (1), 18261206 (1)
    prostate cancer 42 6 9927051 (2), 9426061 (1), 19585490 (1), 18832097 (1)
    glioblastoma 40.1 2 17942911 (1), 18669646 (1)
    glioma 38.4 6 17534449 (1), 18669646 (1), 19001440 (1), 15164982 (1) (see all 5)
    cell damage 31.1 2 12633148 (1), 19528469 (1)
    pancreatic cancer 30.7 1 19393226 (1)

    Genetic Association Database (GAD): CASP7
    Human Genome Epidemiology (HuGE) Navigator: CASP7 (28 documents)

    Export disorders for CASP7 gene to outside databases

    Publications
    for CASP7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CASP7 gene, integrated from 9 sources (see all 621):
    (articles sorted by number of sources associating them with CASP7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis. (PubMed id 8576161)1, 2, 3 Duan H....Dixit V.M. (1996)
    2. Mch3, a novel human apoptotic cysteine protease highly related to CPP32. (PubMed id 8521391)1, 2, 3 Fernandes-Alnemri T.... Alnemri E.S. (1995)
    3. Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32. (PubMed id 8567622)1, 2, 9 Lippke J.A.... Su M.S.-S. (1996)
    4. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. (PubMed id 8755496)1, 2, 9 Fernandes-Alnemri T.... Alnemri E.S. (1996)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. (PubMed id 15200957)1, 2 Bartke T....Jentsch S. (2004)
    7. Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3. (PubMed id 9070923)1, 2 Juan T.S.-C.... Fletcher F.A. (1997)
    8. Calpain-1 cleaves and activates caspase-7. (PubMed id 19617626)1, 9 Gafni J....Ellerby L.M. (2009)
    9. Caspase-7 mediated cleavage of proteasome subunits during apoptosis. (PubMed id 17880920)1, 9 Jang M....Park S.G. (2007)
    10. Processing and activation of CMH-1 by granzyme B. (PubMed id 8631895)1, 9 Gu Y....Su M.S. (1996)

    External Searches for CASP7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CASP7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 840 HGNC: 1508 AceView: CASP7 Ensembl:ENSG00000165806 euGenes: HUgn840
    ECgene: CASP7 Kegg: 840 H-InvDB: CASP7

    Other Databases showing CASP7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CASP7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CASP7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CASP7 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CASP7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CASP7 gene:
    Search GeneIP for patents involving CASP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CASP7 gene

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    About This Section

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