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Aliases for CASP7 Gene

Aliases for CASP7 Gene

  • Caspase 7, Apoptosis-Related Cysteine Peptidase 2 3
  • MCH3 3 4 6
  • Caspase 7, Apoptosis-Related Cysteine Protease 2 3
  • ICE-Like Apoptotic Protease 3 3 4
  • ICE-LAP3 3 4
  • CASP-7 3 4
  • CMH-1 3 4
  • Apoptotic Protease MCH-3 3
  • Apoptotic Protease Mch-3 4
  • EC 3.4.22.60 4
  • Caspase-7 3
  • EC 3.4.22 63
  • LICE2 3

External Ids for CASP7 Gene

Summaries for CASP7 Gene

Entrez Gene Summary for CASP7 Gene

  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for CASP7 Gene

CASP7 (Caspase 7, Apoptosis-Related Cysteine Peptidase) is a Protein Coding gene. Diseases associated with CASP7 include gastrointestinal lymphoma and myocardial infarction. Among its related pathways are ERK Signaling and PAK Pathway. GO annotations related to this gene include cysteine-type peptidase activity and aspartic-type endopeptidase activity. An important paralog of this gene is CASP1.

UniProtKB/Swiss-Prot for CASP7 Gene

  • Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a 216-Asp- -Gly-217 bond. Overexpression promotes programmed cell death

Tocris Summary for CASP7 Gene

  • Caspases (short for cysteinyl aspartate proteases) are involved in the signal transduction pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of many disorders including stroke, Alzheimers disease, myocardial infarction, cancer, and inflammatory disease.

Gene Wiki entry for CASP7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP7 Gene

Genomics for CASP7 Gene

Genomic Location for CASP7 Gene

Start:
113,679,162 bp from pter
End:
113,730,909 bp from pter
Size:
51,748 bases
Orientation:
Plus strand

Genomic View for CASP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CASP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP7 Gene

Regulatory Elements for CASP7 Gene

Transcription factor binding sites by QIAGEN in the CASP7 gene promoter:

Proteins for CASP7 Gene

  • Protein details for CASP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55210-CASP7_HUMAN
    Recommended name:
    Caspase-7
    Protein Accession:
    P55210
    Secondary Accessions:
    • B4DQU7
    • B5BU45
    • D3DRB8
    • Q13364
    • Q53YD5
    • Q5SVL0
    • Q5SVL3
    • Q96BA0

    Protein attributes for CASP7 Gene

    Size:
    303 amino acids
    Molecular mass:
    34277 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce.

    Three dimensional structures from OCA and Proteopedia for CASP7 Gene

    Alternative splice isoforms for CASP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CASP7 Gene

Proteomics data for CASP7 Gene at MOPED

Selected DME Specific Peptides for CASP7 Gene

Post-translational modifications for CASP7 Gene

  • Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for CASP7 Gene

Gene Families for CASP7 Gene

HGNC:
IUPHAR :

Suggested Antigen Peptide Sequences for CASP7 Gene

Graphical View of Domain Structure for InterPro Entry

P55210

UniProtKB/Swiss-Prot:

CASP7_HUMAN
Family:
  • Belongs to the peptidase C14A family.:
    • P55210
genes like me logo Genes that share domains with CASP7: view

Function for CASP7 Gene

Molecular function for CASP7 Gene

GENATLAS Biochemistry: caspase 7,effector,cysteine containing aspartate-specific protease,CASP3 subfamily,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,promoting apoptosis,H3,isoform alpha,interacting with calpain during B cell clonal deletion by apoptosis
UniProtKB/Swiss-Prot CatalyticActivity: Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp- -
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by isatin sulfonamides
UniProtKB/Swiss-Prot Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a 216-Asp- -Gly-217 bond. Overexpression promotes programmed cell death

Enzyme Numbers (IUBMB) for CASP7 Gene

Gene Ontology (GO) - Molecular Function for CASP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity --
GO:0004197 cysteine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 11084335
GO:0008234 cysteine-type peptidase activity TAS 8567622
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process --
genes like me logo Genes that share ontologies with CASP7: view
genes like me logo Genes that share phenotypes with CASP7: view

Animal Models for CASP7 Gene

MGI Knock Outs for CASP7:

No data available for Transcription Factor Targeting and HOMER Transcription for CASP7 Gene

Localization for CASP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CASP7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CASP7 Gene COMPARTMENTS Subcellular localization image for CASP7 gene
Compartment Confidence
cytosol 4
nucleus 4
mitochondrion 3
endoplasmic reticulum 2
cytoskeleton 1
extracellular 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CASP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17167422
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 8576161
GO:0005829 cytosol TAS --
GO:0043231 intracellular membrane-bounded organelle --
genes like me logo Genes that share ontologies with CASP7: view

Pathways for CASP7 Gene

genes like me logo Genes that share pathways with CASP7: view

Gene Ontology (GO) - Biological Process for CASP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001836 release of cytochrome c from mitochondria --
GO:0006508 proteolysis IDA 12888622
GO:0006915 apoptotic process TAS --
GO:0006921 cellular component disassembly involved in execution phase of apoptosis TAS --
GO:0007507 heart development --
genes like me logo Genes that share ontologies with CASP7: view

Compounds for CASP7 Gene

(12) ApexBio Compounds for CASP7 Gene

Compound Action Cas Number
Apoptosis Inhibitor Cell-permeable caspase-3 inhibitor [54135-60-3]
Caspase-3/7 Inhibitor I Cell-permeable and irreversible inhibitor of caspase-3 and -7 [220509-74-0]
Cisplatin Chemotherapy agent, induces apoptosis [15663-27-1]
PAC-1 Procaspase-activating compound, activates procaspase-3 and converts it to caspase-3 [315183-21-2]
Q-VD-Oph Cell-permeable, irreversible pan-caspase inhibitor [1135695-98-5]
VX-765 Novel Caspase-1 inhibitor [273404-37-8]
Z-DEVD-FMK Cell-permeable, and irreversible caspase-3 inhibitor [210344-95-9]
Z-DQMD-FMK Cell-permeable caspase-3 inhibitor
Z-FA-FMK An inhibitor of cysteine proteases, such as cathepsin B.
Z-VAD-FMK Cell-permeable, irreversible pan-caspase inhibitor [187389-52-2]
Z-VDVAD-FMK Cell-permeable and irreversible caspase-2 inhibitor
Z-VEID-FMK Cell-permeable and irreversible caspase-6 inhibitor

(5) Tocris Compounds for CASP7 Gene

Compound Action Cas Number
AZ 10417808 Selective non-peptide caspase-3 inhibitor [331645-84-2]
Cisplatin Potent pro-apoptotic anticancer agent; activates caspase-3 [15663-27-1]
Z-DEVD-FMK Cell-permeable, irreversible caspase-3 inhibitor
Z-DQMD-FMK Caspase-3 inhibitor
Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor [187389-52-2]

(1) Drugbank Compounds for CASP7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Fica
target

(59) Novoseek inferred chemical compound relationships for CASP7 Gene

Compound -log(P) Hits PubMed IDs
adpribose 65.8 13
mevastatin 47.7 2
ceramide 47.6 6
paclitaxel 46.1 7
cisplatin 44.9 13

(5) PharmGKB related drug/compound annotations for CASP7 Gene

Drug/compound Annotation
docetaxel CA
gemcitabine CA
paclitaxel CA
Platinum compounds CA
vinorelbine CA
genes like me logo Genes that share compounds with CASP7: view

Transcripts for CASP7 Gene

Unigene Clusters for CASP7 Gene

Caspase 7, apoptosis-related cysteine peptidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CASP7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - - - - - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - -
SP8: - -
SP9:

Relevant External Links for CASP7 Gene

GeneLoc Exon Structure for
CASP7
ECgene alternative splicing isoforms for
CASP7

Expression for CASP7 Gene

mRNA expression in normal human tissues for CASP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CASP7 Gene

This gene is overexpressed in Colon - Transverse (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CASP7 Gene

SOURCE GeneReport for Unigene cluster for CASP7 Gene Hs.9216

mRNA Expression by UniProt/SwissProt for CASP7 Gene

P55210-CASP7_HUMAN
Tissue specificity: Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain
genes like me logo Genes that share expressions with CASP7: view

Orthologs for CASP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CASP7 35
  • 99.4 (n)
  • 99.7 (a)
CASP7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CASP7 35
  • 87.04 (n)
  • 89.37 (a)
CASP7 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CASP7 35
  • 86.38 (n)
  • 87.38 (a)
CASP7 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Casp7 35
  • 81.74 (n)
  • 82.18 (a)
Casp7 16
Casp7 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CASP7 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CASP7 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Casp7 35
  • 82.29 (n)
  • 85.15 (a)
chicken
(Gallus gallus)
Aves CASP7 35
  • 68.33 (n)
  • 73 (a)
CASP7 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CASP7 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia xCaspase-7 35
tropical clawed frog
(Silurana tropicalis)
Amphibia casp7 35
  • 67.49 (n)
  • 67.49 (a)
Str.16573 35
zebrafish
(Danio rerio)
Actinopterygii casp7 35
  • 65.65 (n)
  • 68.03 (a)
casp7 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta CASPS7 35
  • 50.93 (n)
  • 42.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dcp-1 35
  • 51.6 (n)
  • 46.44 (a)
Dcp-1 36
  • 34 (a)
ManyToMany
decay 36
  • 30 (a)
ManyToMany
Ice 36
  • 34 (a)
ManyToMany
Dcp-1 37
  • 44 (a)
Ice 37
  • 43 (a)
decay 37
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea ced-3 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
Species with no ortholog for CASP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CASP7 Gene

ENSEMBL:
Gene Tree for CASP7 (if available)
TreeFam:
Gene Tree for CASP7 (if available)

Paralogs for CASP7 Gene

genes like me logo Genes that share paralogs with CASP7: view

Variants for CASP7 Gene

Sequence variations from dbSNP and Humsavar for CASP7 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1127684 -- 113,729,321(+) TACTC(A/G)TGGAG synonymous-codon, reference, missense
rs1127685 -- 113,729,871(+) GGTGG(C/T)AACAG utr-variant-3-prime
rs1127686 -- 113,729,880(+) AGTGG(C/T)AGAGT utr-variant-3-prime
rs1127687 -- 113,730,350(+) ACAAA(A/G)CCACT utr-variant-3-prime
rs1800617 -- 113,726,512(+) TCGTT(A/T)CCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CASP7 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
esv2741073 CNV Deletion 23290073

Relevant External Links for CASP7 Gene

HapMap Linkage Disequilibrium report
CASP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASP7 Gene

Disorders for CASP7 Gene

(32) Novoseek inferred disease relationships for CASP7 Gene

Disease -log(P) Hits PubMed IDs
cancer 53.9 9
necrosis 53 16
tumors 51 21
breast cancer 48.7 7
colon cancer 42.1 5

Relevant External Links for CASP7

Genetic Association Database (GAD)
CASP7
Human Genome Epidemiology (HuGE) Navigator
CASP7
genes like me logo Genes that share disorders with CASP7: view

No data available for UniProtKB/Swiss-Prot for CASP7 Gene

Publications for CASP7 Gene

  1. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. (PMID: 8755496) Fernandes-Alnemri T. … Alnemri E.S. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 23
  2. Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32. (PMID: 8567622) Lippke J.A. … Su M.S.-S. (J. Biol. Chem. 1996) 3 4 23
  3. Caspase 7 influences susceptibility to rheumatoid arthritis. (PMID: 17504820) GarcA-a-Lozano J.R. … GonzA!lez-Escribano M.F. (Rheumatology (Oxford) 2007) 3 23 48
  4. Genetic and expression analysis of CASP7 gene in a European Caucasian population with rheumatoid arthritis. (PMID: 18785314) Teixeira V.H. … Petit-Teixeira E. (J. Rheumatol. 2008) 3 23 48
  5. Polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population. (PMID: 19531679) Xu H.L. … Shu X.O. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 23 48

Products for CASP7 Gene

  • Addgene plasmids for CASP7

Sources for CASP7 Gene

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