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CASP7 Gene

protein-coding   GIFtS: 71
GCID: GC10P115428

Caspase 7, Apoptosis-Related Cysteine Peptidase

(Previous names: caspase 7, apoptosis-related cysteine protease)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Caspase 7, Apoptosis-Related Cysteine Peptidase1 2     ICE-LAP32 3
MCH32 3 5     ICE-Like Apoptotic Protease 32 3
Caspase 7, Apoptosis-Related Cysteine Protease1 2     LICE22
Apoptotic Protease Mch-32 3     caspase-72
CASP-72 3     EC 3.4.22.603
CMH-12 3     EC 3.4.228

External Ids:    HGNC: 15081   Entrez Gene: 8402   Ensembl: ENSG000001658067   OMIM: 6017615   UniProtKB: P552103   

Export aliases for CASP7 gene to outside databases

Previous GC identifers: GC10P114346 GC10P114672 GC10P115570 GC10P115103 GC10P109065


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CASP7 Gene:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of
caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes
which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small,
that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is
activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding
multiple isoforms have been observed for this gene. (provided by RefSeq, May 2012)

GeneCards Summary for CASP7 Gene:
CASP7 (caspase 7, apoptosis-related cysteine peptidase) is a protein-coding gene. Diseases associated with CASP7 include gastrointestinal lymphoma, and legionellosis. GO annotations related to this gene include cysteine-type peptidase activity and aspartic-type endopeptidase activity. An important paralog of this gene is CASP16.

UniProtKB/Swiss-Prot: CASP7_HUMAN, P55210
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and
activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose)
polymerase (PARP) at a '216-Asp- -Gly-217' bond. Overexpression promotes programmed cell death

summary for CASP7 Gene:
Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of
apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and
effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with,
upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector
caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the
executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase
Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors
such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For
example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form
part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by
inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of
many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory
disease.

Gene Wiki entry for CASP7 (Caspase 7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CASP7 gene promoter:
         MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CASP7 promoter sequence
   Search Chromatin IP Primers for CASP7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CASP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q25

CASP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CASP7 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P115428:  view genomic region     (about GC identifiers)

Start:
115,438,935 bp from pter      End:
115,490,664 bp from pter
Size:
51,730 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CASP7_HUMAN, P55210 (See protein sequence)
Recommended Name: Caspase-7 precursor  
Size: 303 amino acids; 34277 Da
Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa
(p20) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce
Selected PDB 3D structures from and Proteopedia for CASP7 (see all 29):
1F1J (3D)        1GQF (3D)        1I4O (3D)        1I51 (3D)        1K86 (3D)        1K88 (3D)    
Secondary accessions: B4DQU7 B5BU45 D3DRB8 Q13364 Q53YD5 Q5SVL0 Q5SVL3 Q96BA0
Alternative splicing: 4 isoforms:  P55210-1   P55210-2   P55210-3   P55210-4   (What we call isoform Alpha' is also known as Beta (PubMed:9070923))

Explore the universe of human proteins at neXtProt for CASP7: NX_P55210

Explore proteomics data for CASP7 at MOPED

Post-translational modifications: 

  • Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved
    efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of
    caspase-3, and vice versa, also occur1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for CASP7 (P55210)
     PGYYSWR  CIIINNKNF  IQACRGTELD  KPKLFFIQAC 


    See CASP7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001218.1  NP_001253985.1  NP_001253986.1  NP_001253987.1  NP_203124.1  NP_203125.1  NP_203126.1  

    ENSEMBL proteins: 
     ENSP00000400094   ENSP00000358337   ENSP00000298701   ENSP00000358324   ENSP00000358321  
     ENSP00000358327   ENSP00000398107  
    Reactome Protein details: P55210

    CASP7 Human Recombinant Protein Products:

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    Enzo Life Sciences proteins for CASP7
    OriGene Purified Proteins for CASP7
    OriGene Protein Over-expression Lysate for CASP7
    OriGene MassSpec for CASP7
    OriGene Custom Protein Services for CASP7
    GenScript Custom Purified and Recombinant Proteins Services for CASP7
    Novus Biologicals CASP7 Proteins
    Novus Biologicals CASP7 Lysates
    Sino Biological Recombinant Protein for CASP7
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CASP7

    CASP7 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CASP7
    R&D Systems Antibodies for CASP7 (Caspase-7)
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    OriGene Custom Antibody Services for CASP7
    Novus Biologicals CASP7 Antibodies
    Abcam antibodies for CASP7
    Cloud-Clone Corp. Antibodies for CASP7
    ThermoFisher Antibody for CASP7
    LSBio Antibodies in human, mouse, rat for CASP7

    CASP7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript CASP7-Activity-based Protease?src=genec Assay for Compound Screening
    Enzo Life Sciences assays for CASP7
    Cloud-Clone Corp. ELISAs for CASP7
    Cloud-Clone Corp. CLIAs for CASP7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CASP: Caspases

    IUPHAR Guide to PHARMACOLOGY protein family classification: Caspase 7
    Caspases

    Selected InterPro protein domains (see all 6):
     IPR001309 Pept_C14_ICE_p20
     IPR015471 Casp7
     IPR002138 Pept_C14_p10
     IPR015917 Pept_C14A_p45_core
     IPR011600 Pept_C14_caspase

    Graphical View of Domain Structure for InterPro Entry P55210

    ProtoNet protein and cluster: P55210

    2 Blocks protein domains:
    IPB001309 Caspase-1
    IPB002398 Interleukin-1B converting enzyme signature


    UniProtKB/Swiss-Prot: CASP7_HUMAN, P55210
    Similarity: Belongs to the peptidase C14A family


    CASP7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CASP7_HUMAN, P55210
    Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and
    activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose)
    polymerase (PARP) at a '216-Asp- -Gly-217' bond. Overexpression promotes programmed cell death
    Catalytic activity: Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of
    Asp-Glu-Val-Asp- -
    Enzyme regulation: Inhibited by isatin sulfonamides

         Genatlas biochemistry entry for CASP7:
    caspase 7,effector,cysteine containing aspartate-specific protease,CASP3 subfamily,stored in the mitochondrial
    intermembrane space and released into cytosol after appropriate apoptotic stimuli,promoting apoptosis,H3,isoform
    alpha,interacting with calpain during B cell clonal deletion by apoptosis

         Enzyme Numbers (IUBMB): EC 3.4.222 EC 3.4.22.601

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004190aspartic-type endopeptidase activity IEA--
    GO:0004197cysteine-type endopeptidase activity TAS--
    GO:0005515protein binding IPI11084335
    GO:0008234cysteine-type peptidase activity TAS8567622
    GO:0097153cysteine-type endopeptidase activity involved in apoptotic process IEA--
         
    CASP7 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Casp7):
     cardiovascular system  cellular  hematopoietic system  immune system  mortality/aging 
     nervous system  vision/eye 

    CASP7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CASP7: Casp7tm1.1Acau Casp7tm1Flv

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CASP7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CASP7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CASP7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CASP7

    miRNA
    Products:
        
    miRTarBase miRNAs that target CASP7:
    hsa-mir-192-5p (MIRT026826), hsa-mir-484 (MIRT042101), hsa-mir-132-3p (MIRT021838), hsa-mir-26b-5p (MIRT030234), hsa-mir-215-5p (MIRT024257), hsa-mir-122-5p (MIRT023343), hsa-mir-106b-5p (MIRT020444)

    Block miRNA regulation of human, mouse, rat CASP7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CASP7 (see all 27):
    hsa-miR-3673 hsa-miR-106a hsa-miR-29a hsa-miR-29c hsa-miR-507 hsa-miR-570 hsa-miR-93 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidCASP7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CASP7
    Predesigned siRNA for gene silencing in human, mouse, rat CASP7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CASP7

    Clone
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    OriGene clones in human, mouse for CASP7 (see all 23)
    OriGene ORF clones in mouse, rat for CASP7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CASP7 (NM_033340)
    Sino Biological Human cDNA Clone for CASP7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASP7

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CASP7 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CASP7_HUMAN, P55210: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    mitochondrion3
    endoplasmic reticulum2
    cytoskeleton1
    extracellular1
    plasma membrane1
    vacuole1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17167422
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS8576161
    GO:0005829cytosol TAS--
    GO:0043231intracellular membrane-bounded organelle ----

    CASP7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CASP7 About   (see all 42)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TWEAK Pathway0.87
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    DR3 Signaling0.87
    Apoptotic Pathways Triggered By HIV10.42
    TNFR1 Pathway0.56
    Apoptosis through Death Receptors0.42
    TNF Signaling0.55
    Fas Signaling0.35
    2Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    FAS pathway and Stress induction of HSP regulation0.44
    Apoptosis and survival FAS signaling cascades0.44
    Caspase cascade in apoptosis0.42
    3LT-BetaR Pathway
    Apoptosis and survival Lymphotoxin beta receptor signaling0.46
    LT-BetaR Pathway0.46
    4Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44
    5p53 Signaling
    p53 Signaling0.38
    p53 Pathway0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CASP7
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CASP7 (see all 27)
        Caspase Cascade
    TWEAK Pathway
    14-3-3 Induced Apoptosis
    DHA Signaling
    LT-BetaR Pathway

    1 Cell Signaling Technology (CST) Pathway for CASP7
        Apoptosis and Autophagy

    2 Tocris Bioscience Pathways for CASP7
        Apoptosis Pathway
    VEGF Pathway

    5 GeneGo (Thomson Reuters) Pathways for CASP7
        Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Apoptosis and survival Lymphotoxin-beta receptor signaling
    Apoptosis and survival TNFR1 signaling pathway

    Selected BioSystems Pathways for CASP7 (see all 17)
        MAPK signaling pathway
    Apoptosis
    NOD pathway
    Apoptosis Modulation and Signaling
    FAS pathway and Stress induction of HSP regulation

    3 Sino Biological Pathways for CASP7
        EGFR Signaling Pathway
    p53 Pathway
    Death Receptor Signaling

    5 Reactome Pathways for CASP7
        Activation of caspases through apoptosome-mediated cleavage
    SMAC-mediated dissociation of IAP:caspase complexes
    Apoptotic cleavage of cellular proteins
    SMAC binds to IAPs
    Caspase-mediated cleavage of cytoskeletal proteins


    Selected Kegg Pathways  (Kegg details for CASP7) (see all 6):
        Apoptosis
    TNF signaling pathway
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Pertussis


    CASP7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CASP7 (see all 8): 
              Parkinson's Disease in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Apoptosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Neurotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CASP7

    Selected Interacting proteins for CASP7 (P552101, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001836release of cytochrome c from mitochondria IEA--
    GO:0006508proteolysis IDA12888622
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0007507heart development IEA--

    CASP7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CASP7
    Selected ApexBio Compounds for CASP7 (see all 12)     About this table
    CompoundAction CAS #
    Apoptosis InhibitorCell-permeable caspase-3 inhibitor[54135-60-3]
    Caspase-3/7 Inhibitor ICell-permeable and irreversible inhibitor of caspase-3 and -7[220509-74-0]
    CisplatinChemotherapy agent, induces apoptosis[15663-27-1]
    PAC-1Procaspase-activating compound, activates procaspase-3 and converts it to caspase-3[315183-21-2]
    Q-VD-OphCell-permeable, irreversible pan-caspase inhibitor[1135695-98-5]
    VX-765 Novel Caspase-1 inhibitor[273404-37-8]
    Z-DEVD-FMKCell-permeable, and irreversible caspase-3 inhibitor[210344-95-9]
    Z-DQMD-FMKCell-permeable caspase-3 inhibitor--
    Z-FA-FMKEffector caspases 2, 3, 5, and 7--
    Z-VAD-FMKCell-permeable, irreversible pan-caspase inhibitor[187389-52-2]

    Compounds for CASP7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AZ 10417808Selective non-peptide caspase-3 inhibitor[331645-84-2]
    Z-DQMD-FMKCaspase-3 inhibitor--
    CisplatinPotent pro-apoptotic anticancer agent; activates caspase-3[15663-27-1]
    Z-DEVD-FMK Cell-permeable, irreversible caspase-3 inhibitor --
    Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor [187389-52-2]

    1 DrugBank Compound for CASP7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Fica-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for CASP7 gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adpribose 65.8 14 11403964 (2), 14679006 (1), 11720482 (1), 18806828 (1) (see all 12)
    mevastatin 47.7 2 15385411 (1), 16427097 (1)
    ceramide 47.6 7 17893663 (1), 16170023 (1), 16359673 (1), 15255262 (1) (see all 6)
    paclitaxel 46.1 8 19674193 (2), 17854074 (1), 11278107 (1), 15700118 (1) (see all 6)
    cisplatin 44.9 29 20034524 (2), 19111676 (2), 17922809 (1), 10194341 (1) (see all 11)
    cd 437 44.8 2 11156424 (2)
    polyadenosine diphosphate ribose 43.6 3 12828737 (1), 10510942 (1)
    etoposide 41.2 8 12665508 (2), 17941090 (1), 19426747 (1), 18403493 (1) (see all 6)
    phosphatidylserine 39.7 10 17707271 (2), 20441051 (1), 16192639 (1), 19357081 (1) (see all 8)
    rottlerin 39.4 1 18413747 (1)



    CASP7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CASP7 gene (7 alternative transcripts): 
    NM_001227.4  NM_001267056.1  NM_001267057.1  NM_001267058.1  NM_033338.5  NM_033339.4  NM_033340.3  

    Unigene Cluster for CASP7:

    Caspase 7, apoptosis-related cysteine peptidase
    Hs.9216  [show with all ESTs]
    Unigene Representative Sequence: NM_033338
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429617 ENST00000369331(uc001lam.3 uc001lan.3) ENST00000345633
    ENST00000369318(uc010qsb.2) ENST00000369315 ENST00000468790 ENST00000487232
    ENST00000369321(uc001lao.3 uc001lap.3 uc001laq.3 uc010qsa.2)
    ENST00000452490
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CASP7 (see all 27):
    hsa-miR-3673 hsa-miR-106a hsa-miR-29a hsa-miR-29c hsa-miR-507 hsa-miR-570 hsa-miR-93 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidCASP7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CASP7
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    Additional mRNA sequence: 

    AB451281.1 AB451413.1 AK223489.1 AK298964.1 AK300578.1 AK301437.1 BC015799.1 BT006683.1 
    BX647973.1 U37448.1 U37449.1 U39613.1 U40281.1 U67206.1 U67320.1 

    11 DOTS entries:

    DT.415134  DT.91711171  DT.100792238  DT.121261395  DT.95166647  DT.422074  DT.100691275  DT.121261310 
    DT.97841342  DT.100712135  DT.121261296 

    Selected AceView cDNA sequences (see all 143):

    AW132025 BU175191 AU117167 CB045242 BQ008163 AA863347 BQ007179 U37448 
    BC015799 AI740532 AL542189 BU197358 AA297274 BU632085 AA983777 CD366838 
    AA297423 BE644891 AA370823 AW028999 AU130224 AA890033 U37449 AA782107 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CASP7 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c
    SP1:              -     -     -     -     -     -     -           -     -     -     -                                   -                                 
    SP2:                                            -                 -     -     -     -                                         -                           
    SP3:                                                              -     -     -     -                                         -                           
    SP4:              -     -     -     -     -     -     -           -     -     -     -                                         -                           
    SP5:                                            -     -           -     -     -     -                                         -                           


    ECgene alternative splicing isoforms for CASP7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CASP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAGAACAA
    CASP7 Expression
    About this image


    CASP7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Choroid Plexus
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Neurons
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
     
     Neural Tube (Nervous System)
             Diencephalic Roof Plate
     
     Colon (Gastrointestinal Tract)
    CASP7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CASP7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.9216

    UniProtKB/Swiss-Prot: CASP7_HUMAN, P55210
    Tissue specificity: Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in
    testis. No expression in the brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CASP7 (see all 8): 
              Parkinson's Disease in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Apoptosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Neurotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CASP7 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Casp71 , 5 caspase 71, 5 81.74(n)1
    82.18(a)1
      19 (51.84 cM)5
    123691  NM_007611.21  NP_031637.11 
     563971295 
    chicken
    (Gallus gallus)
    Aves CASP71 caspase 7, apoptosis-related cysteine peptidase 68.33(n)
    73(a)
      423901  XM_421764.3  XP_421764.3 
    lizard
    (Anolis carolinensis)
    Reptilia CASP76
    caspase 7, apoptosis-related cysteine peptidase
    61(a)
    1 ↔ 1
    GL343204.1(600281-637624)
    African clawed frog
    (Xenopus laevis)
    Amphibia xCaspase-72 caspase-7 75.89(n)    AB038170.1 
    zebrafish
    (Danio rerio)
    Actinopterygii casp71 caspase 7, apoptosis-related cysteine peptidase 65.65(n)
    68.03(a)
      553634  NM_001020607.1  NP_001018443.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dcp-11 , 3 apoptosis effector caspase3
    Death caspase-11
    44(a)
    (best of 3)3
    51.6(n)1
    46.44(a)1
      59E33
    377291  NM_057626.31  NP_476974.11 


    ENSEMBL Gene Tree for CASP7 (if available)
    TreeFam Gene Tree for CASP7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CASP7 gene
    CASP162  CASP62  CASP82  CASP122  CASP92  CASP32  CASP22  CASP142  
    CASP12  CASP52  CASP102  CASP42  
    Selected SIMAP similar genes for CASP7 using alignment to 3 protein entries:     CASP7_HUMAN (see all proteins) (see all similar genes):
    NF2    HMGA2    C16orf89    GVQW1    FLJ20555    KIAA1651
    MYB    SHANK2    FAM175A    PKN1    TMEM135    DNAPTP3
    CASP3    FP6651    EIF3L    AURA2    DKFZp686N1815    LINC00596

    CASP7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CASP7 (see all 1181)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882188801,2
    --109064310(+) ACGGGA/GGCAAC 4 -- us2k10--------
    rs1921037231,2
    --109064319(+) ACTTCA/GCTGAG 4 -- us2k10--------
    rs1389120431,2
    --115437158(+) TGTTGC/TGGGTG 2 -- us2k10--------
    rs1833336731,2
    --115437266(+) ACTAAC/GCTGCA 2 -- us2k10--------
    rs111964171,2
    H--115437340(+) TGATTC/ATACTT 2 -- us2k14Minor allele frequency- A:0.00NS EA 414
    rs1143044681,2
    F--115437475(+) ACCTGC/AAAGAT 6 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1832232741,2
    --115437654(+) GCTCAC/TTGCAA 6 -- us2k10--------
    rs127637871,2
    C--115437703(+) CCTCCT/CGAGTA 6 -- us2k12Minor allele frequency- C:0.00NA CSA 3
    rs342156721,2
    C--115437746(+) GCTAA-/TTTTTT 6 -- us2k12Minor allele frequency- T:0.25NA CSA 4
    rs358870321,2
    C--115437772(+) GACAGG/AGTTTC 6 -- us2k11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for CASP7 (115438935 - 115490664 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CASP7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2741073CNV Deletion23290073
    nsv7211OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601761    OMIM disorders: --

    Selected diseases for CASP7 (see all 72):    
    About MalaCards
    gastrointestinal lymphoma    legionellosis    myocardial infarction    breast adenocarcinoma
    childhood leukemia    werner syndrome    traumatic brain injury    brain injury
    fibrosarcoma    testicular cancer    gastrointestinal stromal tumor    alzheimer's disease
    synovitis    vitiligo    septic shock    retinoblastoma
    pertussis    chronic myeloid leukemia    pancreatic cancer    medulloblastoma


    CASP7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for CASP7 gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 53.9 13 17234160 (1), 19117056 (1), 16552962 (1), 19846905 (1) (see all 9)
    necrosis 53 18 18980241 (1), 15204708 (1), 19306923 (1), 11755217 (1) (see all 16)
    tumors 51 23 11403964 (2), 16609042 (1), 16452233 (1), 18806828 (1) (see all 20)
    breast cancer 48.7 9 19009586 (1), 16430140 (1), 20348950 (1), 15283467 (1) (see all 7)
    colon cancer 42.1 8 11381362 (3), 12907606 (1), 18261206 (1)
    prostate cancer 42 6 9927051 (2), 9426061 (1), 19585490 (1), 18832097 (1)
    glioblastoma 40.1 2 17942911 (1), 18669646 (1)
    glioma 38.4 6 17534449 (1), 18669646 (1), 19001440 (1), 15164982 (1) (see all 5)
    cell damage 31.1 2 12633148 (1), 19528469 (1)
    pancreatic cancer 30.7 1 19393226 (1)

    Genetic Association Database (GAD): CASP7
    Human Genome Epidemiology (HuGE) Navigator: CASP7 (28 documents)

    Export disorders for CASP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CASP7 gene, integrated from 10 sources (see all 634):
    (articles sorted by number of sources associating them with CASP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis. (PubMed id 8576161)1, 2, 3 Duan H....Dixit V.M. (J. Biol. Chem. 1996)
    2. Mch3, a novel human apoptotic cysteine protease highly related to CPP32. (PubMed id 8521391)1, 2, 3 Fernandes-Alnemri T.... Alnemri E.S. (Cancer Res. 1995)
    3. Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32. (PubMed id 8567622)1, 2, 9 Lippke J.A.... Su M.S.-S. (J. Biol. Chem. 1996)
    4. Polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population. (PubMed id 19531679)1, 4, 9 Xu H.L....Shu X.O. (amp 2009)
    5. Caspase 7 influences susceptibility to rheumatoid arthritis. (PubMed id 17504820)1, 4, 9 GarcA-a-Lozano J.R....GonzA!lez-Escribano M.F. (Rheumatology (Oxford) 2007)
    6. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. (PubMed id 8755496)1, 2, 9 Fernandes-Alnemri T.... Alnemri E.S. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    7. TP53 codon 72 polymorphism associated with prognosis in patients with advanced gastric cancer treated with paclitaxel and cisplatin. (PubMed id 19052714)1, 4, 9 Kim J.G....Yu W. (Cancer Chemother. Pharmacol. 2009)
    8. Genetic and expression analysis of CASP7 gene in a European Caucasian population with rheumatoid arthritis. (PubMed id 18785314)1, 4, 9 Teixeira V.H....Petit-Teixeira E. (J. Rheumatol. 2008)
    9. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 840 HGNC: 1508 AceView: CASP7 Ensembl:ENSG00000165806 euGenes: HUgn840
    ECgene: CASP7 Kegg: 840 H-InvDB: CASP7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CASP7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CASP7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CASP7 gene:
    Search GeneIP for patents involving CASP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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