CASP6 Gene
protein-coding GIFtS: 67
GCID: GC04M110609
|
|
caspase 6, apoptosis-related cysteine peptidase(Previous names: caspase 6, apoptosis-related cysteine protease )
| |
Aliases
for CASP6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Caspase 6, Apoptosis-Related Cysteine Peptidase1 2 | | EC 3.4.22.593 8 | | MCH21 2 3 5 | | Caspase-61 | | Caspase 6, Apoptosis-Related Cysteine Protease1 2 | | CASP-63 | | Apoptotic Protease Mch-22 3 | | EC 3.4.228 |
Export aliases for CASP6 gene to outside databasesPrevious GC identifers: GC04M111026 GC04M110880 GC04M111068 GC04M110967 GC04M110829 GC04M106342 |
Summaries
for CASP6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CASP6:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequentialactivation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactiveproenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large andsmall, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought tofunction as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in twotranscript variants that encode different isoforms. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CASP6_HUMAN, P55212Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose)polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death
 summary
for CASP6: Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of
apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and
effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with,
upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector
caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the
executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase
Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors
such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For
example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form
part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by
inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of
many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory
disease.
Gene Wiki entry for CASP6 (Caspase 6)
|
Genomic Views
for CASP6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CASP6 gene promoter:
HOXA9B HOXA9 PPAR-alpha AML1a FOXF2 Meis-1b Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CASP6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASP6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q25 Ensembl cytogenetic band: 4q25 HGNC cytogenetic band: 4q25CASP6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M110609: view genomic region
(about GC identifiers)
Start:
|
110,609,785 bp from pter |
End:
|
110,624,739 bp from pter |
Size:
|
14,955 bases |
Orientation:
|
minus strand |
|
Proteins
for CASP6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CASP6_HUMAN, P55212 (See
protein sequence)Recommended Name: Caspase-6 precursor Size: 293 amino acids; 33310 Da
Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) anda 11 kDa (p11) subunit. Interacts with BIRC6/bruce
Subcellular location: Cytoplasm
6/15 PDB 3D structures from  and Proteopedia  for CASP6 (see all 15):1MI9 (3D)
2WDP (3D)
3K7E (3D)
3NKF (3D)
3NR2 (3D)
3OD5 (3D)
Secondary accessions: Q9BQE7Alternative splicing: 2 isoforms: P55212-1 P55212-2 Explore the universe of human proteins at neXtProt for CASP6: NX_P55212
Post-translational modifications:
Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P55212
4/7 DME Specific Peptides for CASP6 (P55212) (see all 7)
CASP6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001217.2 NP_116787.1
ENSEMBL proteins: ENSP00000285333 ENSP00000265164 ENSP00000427669 ENSP00000424080 Reactome Protein details: P55212
Human Recombinant Protein Products for CASP6:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
CASP6 for ontologies About GeneDecksing
CASP6 Antibody Products:
Assay Products for CASP6: |
Protein
Domains /
Families
for CASP6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CASP6 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P55212ProtoNet protein and cluster: P55212 2 Blocks protein families: IPB001309 Caspase-1 IPB002398 Interleukin-1B converting enzyme signature
UniProtKB/Swiss-Prot: CASP6_HUMAN, P55212Similarity: Belongs to the peptidase C14A family |
Function
for CASP6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CASP6_HUMAN, P55212Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose)polymerase in vitro, as well as lamins. Overexpression promotes programmed cell deathCatalytic activity: Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp--Enzyme regulation: Activation is suppressed by phosphorylation at Ser-257 Genatlas biochemistry entry for CASP6:caspase 6,effector,cysteine containing aspartate-specific protease,CASP3 subfamily,with two isoforms alpha andbeta,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptoticstimuli,promoting apoptosis
Enzyme Numbers (IUBMB): EC 3.4.22.591 2 EC 3.4.222
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
CASP6 for ontologies About GeneDecksing
Phenotypes:
7 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Casp6):
CASP6 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for CASP6: Casp6tm1.2Xen Casp6tm1Flv
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CASP6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CASP6 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CASP6 (NM_032992) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CASP6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASP6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP6 |
|
Pathways & Interactions
for CASP6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/31 super-pathways (see all 31) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TWEAK Pathway | | | 2 | Apoptosis and survival_Caspase cascade | | | 3 | Apoptotic cleavage of cellular proteins | | | 4 | TRAF Pathway | | | 5 | TNF-Induced Apoptosis Implicating Sphingolipids | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for CASP6
1  R&D Systems Pathway for CASP6
5/24 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CASP6 (see all 24)
1 
Cell Signaling Technology (CST) Pathway for CASP6
2 Tocris Bioscience Pathways for CASP6
3  GeneGo (Thomson Reuters) Pathways for CASP6
5/11  BioSystems Pathways for CASP6 (see all 11)
5 
Reactome Pathways for CASP6
1 
Kegg Pathway (Kegg details for CASP6):
CASP6 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CASP6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/58 Interacting proteins for CASP6 (P552121, 2, 3 ENSP000002651644) via UniProtKB, MINT, STRING, and/or I2D (see all 58)About this table
Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table
CASP6 for ontologies About GeneDecksing
|
Drugs & Compounds
for CASP6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CASP6 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for CASP6 |
Compounds for CASP6 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Z-VEID-FMK | Irreversible caspase-6 inhibitor | -- | | Ac-LEHD-AFC | Fluorogenic caspase substrate | [210345-03-2] | | Z-VAD-FMK | Cell-permeable, irreversible caspase inhibitor | -- |
10/20 Novoseek chemical compound relationships for CASP6 gene (see all 20) About this table
Search CenterWatch for drugs/clinical trials and news about CASP6
|
Transcripts
for CASP6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CASP6 gene (2 alternative transcripts): NM_001226.3 NM_032992.2 Unigene Cluster for CASP6: Caspase 6, apoptosis-related cysteine peptidase Hs.654616 [show with all ESTs]Unigene Representative Sequence: NM_0012268 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000352981(uc003hzo.1) ENST00000265164(uc003hzn.1) ENST00000507550
ENST00000505117 ENST00000510324 ENST00000508203 ENST00000503684 ENST00000505486
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CASP6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CASP6 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CASP6 (NM_032992) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CASP6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASP6 |
Additional cDNA sequence: BC000305.2 BC004460.1 U20536.1 U20537.1 9 DOTS entries: DT.453087 DT.100772649 DT.121269705 DT.100783987 DT.100783993 DT.100692964 DT.99990009 DT.95220751 DT.95296153 24/436 AceView cDNA sequences (see all 436): AY359024 CB163750 F09005 BM714055 CR616049 CR610634 AA234318 AA205188 AA844025 AA235373 N91912 CR618232 AA662174 AI218487 BX378996 BC004460 BX092618 BX089479 AF306567 BM837197 BM924043 BP344820 CA950903 AW589944
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CASP6 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CASP6
|
Expression
for CASP6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CASP6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGAAAGGGT
About this image
See CASP6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CASP6
SOURCE GeneReport for Unigene cluster: Hs.654616
SABiosciences Expression via Pathway-Focused PCR Arrays including CASP6:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CASP6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CASP6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CASP6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASP6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP6 |
Orthologs
for CASP6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CASP6 gene from 5/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CASP61 |
caspase 6, apoptosis-related cysteine peptidase |
72.76(n)
72.4(a) |
|
395477 NM_204726.1 NP_990057.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CASP66 |
-- |
74(a) |
1 ↔ 1 |
5(144457372-144466776) |
African clawed frog
(Xenopus laevis) |
Amphibia |
xCaspase-62 |
caspase-6 |
75.84(n) |
|
AB038169.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
casp61 |
caspase 6, apoptosis-related cysteine peptidase |
66.91(n)
69.49(a) |
|
552927 NM_001020497.1 NP_001018333.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Ice3 |
apoptosis effector caspase |
40(a)
(best of 3) |
|
99C1 -- |
ENSEMBL Gene Tree for CASP6 (if available)
TreeFam Gene Tree for CASP6 (if available) |
Paralogs
for CASP6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CASP6 gene
- CASP162 CASP82 CASP122 CASP92 CASP72 CASP32 CASP22 CASP142
- CASP12 CASP52 CASP102 CASP42
4 SIMAP similar genes for CASP6 using alignment to 3 protein entries: CASP6_HUMAN (see all proteins):CASP3 CASP7 DKFZp686N1815 CASP8
CASP6 for paralogs About GeneDecksing
|
Genomic Variants
for CASP6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CASP6 (110609785 - 110624739 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CASP6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CASP6 |
|
Disorders
/ Diseases
for CASP6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CASP6 for disorders About GeneDecksing
OMIM gene information: 601532
OMIM disorders: --
20/42  diseases for CASP6 (see all 42): About MalaCardsdna topoisomerase i non-small cell lung carcinoma temporal lobe epilepsy non-hodgkin lymphoma
gastrointestinal stromal tumor hodgkin's lymphoma alcohol dependence neurodegenerative disease
huntington's disease thoracic cancer renal cell carcinoma gallbladder carcinoma
gastroenteritis alzheimer's disease neurodegeneration colon cancer
keloids gastric cancer lung carcinoma colorectal cancer
1 disease from the University of Copenhagen DISEASES database for CASP6:Huntington's disease 10/23 Novoseek disease relationships for CASP6 gene (see all 23) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| neuropil threads |
61.5 |
12 |
15277226 (2), 18487604 (2), 17392160 (1), 19915487 (1) |
| neurofibrillary tangles |
38.6 |
13 |
15277226 (2), 18487604 (2), 17392160 (1), 19915487 (1) (see all 5) |
| leukemia |
37.1 |
1 |
18392682 (1) |
| huntington disease |
35.8 |
1 |
19326941 (1) |
| tumors |
32.3 |
21 |
15523899 (2), 20437871 (2), 15210759 (1), 9171342 (1) (see all 13) |
| alzheimers disease |
31.5 |
32 |
15277226 (6), 18487604 (4), 17392160 (2), 19915487 (2) (see all 10) |
| necrosis |
30.8 |
6 |
19017654 (1), 12815280 (1), 16977583 (1), 15298760 (1) (see all 6) |
| breast cancer |
27.9 |
4 |
12815280 (1), 16977583 (1), 10832593 (1), 11438643 (1) |
| cancer |
25.2 |
6 |
16948818 (2), 16925970 (1), 18497562 (1) |
| senile plaques |
21.1 |
12 |
15277226 (2), 18487604 (2), 17392160 (1), 19915487 (1) |
Human Genome Epidemiology (HuGE) Navigator: CASP6 (10 documents)
Export disorders for CASP6 gene to outside databases
|
Publications
for CASP6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CASP6 gene, integrated from 9 sources (see all 317):
(articles sorted by number of sources associating them with CASP6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. (PubMed id 7796396)1, 2, 3, 9 Fernandes-Alnemri T.... Alnemri E.S. (1995)
- Regulation of caspase-6 and FLIP by the AMPK family member ARK5. (PubMed id 15273717)1, 2, 9 Suzuki A.... Esumi H. (2004)
- Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and Ich-1, involved in cellular apoptosis. (PubMed id 8780721)1, 3, 9 Tiso N....Danieli G.A. (1996)
- Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. (PubMed id 15200957)1, 2 Bartke T....Jentsch S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. (PubMed id 8900201)1, 2 Srinivasula S.M....Alnemri E.S. (1996)
- Caspase-6 activation in familial alzheimer disease br ains carrying amyloid precursor protein or presenilin i or presenilin II mutati ons. (PubMed id 19915487)1, 9 Albrecht S....LeBlanc A.C. (2009)
- Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas. (PubMed id 16948818)1, 9 Lee J.W....Lee S.H. (2006)
- Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53. (PubMed id 18497562)1, 9 Chan J.Y....Lee S.C. (2008)
- Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain. (PubMed id 12232792)1, 9 Cowling V. and Downward J. (2002)
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External Searches for CASP6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CASP6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CASP6 gene
(According to HUGE)
About This Section
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Specialized Databases showing CASP6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for CASP6 gene:
Search GeneIP for patents involving CASP6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CASP6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for CASP6 | | OriGene shRNA RFP for CASP6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CASP6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CASP6 | | | OriGene Protein Over-expression Lysate for CASP6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CASP6 | | OriGene 3'-UTR Clone for CASP6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CASP6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CASP6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CASP6 | | OriGene Custom Protein Services for CASP6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CASP6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CASP6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASP6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASP6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASP6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CASP6 |
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| | | | Tocris compounds for CASP6 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP6 |
|  |  |  |  | | | | ThermoFisher Antibodies for CASP6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASP6 |
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