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Aliases for CASP6 Gene

Aliases for CASP6 Gene

  • Caspase 6, Apoptosis-Related Cysteine Peptidase 2 3
  • MCH2 3 4 6
  • Caspase 6, Apoptosis-Related Cysteine Protease 2 3
  • EC 4 63
  • Apoptotic Protease MCH-2 3
  • Apoptotic Protease Mch-2 4
  • Caspase-6 3
  • EC 3.4.22 63
  • CASP-6 4

External Ids for CASP6 Gene

Previous GeneCards Identifiers for CASP6 Gene

  • GC04M111026
  • GC04M110880
  • GC04M111068
  • GC04M110967
  • GC04M110829
  • GC04M110609
  • GC04M106342

Summaries for CASP6 Gene

Entrez Gene Summary for CASP6 Gene

  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CASP6 Gene

CASP6 (Caspase 6, Apoptosis-Related Cysteine Peptidase) is a Protein Coding gene. Diseases associated with CASP6 include thoracic cancer and myocardial infarction. Among its related pathways are Akt Signaling and ERK Signaling. GO annotations related to this gene include identical protein binding and cysteine-type endopeptidase activity. An important paralog of this gene is CASP1.

UniProtKB/Swiss-Prot for CASP6 Gene

  • Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death

Tocris Summary for CASP6 Gene

  • Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory disease.

Gene Wiki entry for CASP6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP6 Gene

Genomics for CASP6 Gene

Regulatory Elements for CASP6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CASP6 Gene

109,688,622 bp from pter
109,709,224 bp from pter
20,603 bases
Minus strand

Genomic View for CASP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CASP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP6 Gene

Proteins for CASP6 Gene

  • Protein details for CASP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q9BQE7

    Protein attributes for CASP6 Gene

    293 amino acids
    Molecular mass:
    33310 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce.

    Three dimensional structures from OCA and Proteopedia for CASP6 Gene

    Alternative splice isoforms for CASP6 Gene


neXtProt entry for CASP6 Gene

Proteomics data for CASP6 Gene at MOPED

Post-translational modifications for CASP6 Gene

  • Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CASP6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CASP6 Gene

Gene Families for CASP6 Gene


Suggested Antigen Peptide Sequences for CASP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C14A family.
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP6: view

Function for CASP6 Gene

Molecular function for CASP6 Gene

GENATLAS Biochemistry:
caspase 6,effector,cysteine containing aspartate-specific protease,CASP3 subfamily,with two isoforms alpha and beta,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,promoting apoptosis
UniProtKB/Swiss-Prot CatalyticActivity:
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp- -
UniProtKB/Swiss-Prot EnzymeRegulation:
Activation is suppressed by phosphorylation at Ser-257.
UniProtKB/Swiss-Prot Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death

Enzyme Numbers (IUBMB) for CASP6 Gene

Gene Ontology (GO) - Molecular Function for CASP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 12888622
GO:0008234 cysteine-type peptidase activity TAS 7796396
GO:0042802 identical protein binding IPI 20890311
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA --
genes like me logo Genes that share ontologies with CASP6: view
genes like me logo Genes that share phenotypes with CASP6: view

Animal Models for CASP6 Gene

MGI Knock Outs for CASP6:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CASP6

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for CASP6 Gene

Localization for CASP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CASP6 Gene


Subcellular locations from

Jensen Localization Image for CASP6 Gene COMPARTMENTS Subcellular localization image for CASP6 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CASP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CASP6: view

Pathways for CASP6 Gene

genes like me logo Genes that share pathways with CASP6: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CASP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 12888622
GO:0006915 apoptotic process TAS --
GO:0006921 cellular component disassembly involved in execution phase of apoptosis TAS --
GO:0012501 programmed cell death TAS --
GO:0030855 epithelial cell differentiation IEP 21492153
genes like me logo Genes that share ontologies with CASP6: view

Drugs for CASP6 Gene

(5) Tocris Compounds for CASP6 Gene

Compound Action Cas Number
Ac-LEHD-AFC Fluorogenic caspase substrate [210345-03-2]
Cisplatin Potent pro-apoptotic anticancer agent; activates caspase-3 [15663-27-1]
Z-DQMD-FMK Caspase-3 inhibitor
Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor [187389-52-2]
Z-VDVAD-FMK Irreversible caspase-2 inhibitor

(1) ApexBio Compounds for CASP6 Gene

Compound Action Cas Number
Apoptosis Activator 2 Indoledione caspase activator, cell-permeable [79183-19-0]

(1) IUPHAR Ligand for CASP6 Gene

Ligand Type Action Affinity Pubmed IDs
Z-VEID-FMK Inhibitor Inhibition

(20) Novoseek inferred chemical compound relationships for CASP6 Gene

Compound -log(P) Hits PubMed IDs
etoposide 48.5 3
cysteine 42.8 4
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 34.2 1
camptothecin 31.1 2
cycloheximide 28.1 1
genes like me logo Genes that share compounds with CASP6: view

Compound Products

Transcripts for CASP6 Gene

Unigene Clusters for CASP6 Gene

Caspase 6, apoptosis-related cysteine peptidase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CASP6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CASP6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2: - -
SP3: - -
SP4: -
SP6: - - - - -

Relevant External Links for CASP6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CASP6 Gene

mRNA expression in normal human tissues for CASP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CASP6 Gene

This gene is overexpressed in Colon - Transverse (4.6).

Protein differential expression in normal tissues for CASP6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.7), Lymph node (9.4), and Fetal gut (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CASP6 Gene

SOURCE GeneReport for Unigene cluster for CASP6 Gene Hs.654616

genes like me logo Genes that share expressions with CASP6: view

Expression partners for CASP6 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CASP6 Gene

Orthologs for CASP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CASP6 35
  • 86.3 (n)
  • 86.3 (a)
CASP6 36
  • 86 (a)
(Canis familiaris)
Mammalia CASP6 35
  • 88.7 (n)
  • 90.07 (a)
CASP6 36
  • 53 (a)
(Mus musculus)
Mammalia Casp6 35
  • 84.43 (n)
  • 90.88 (a)
Casp6 16
Casp6 36
  • 90 (a)
(Pan troglodytes)
Mammalia CASP6 35
  • 96.79 (n)
  • 95.93 (a)
(Rattus norvegicus)
Mammalia Casp6 35
  • 84.73 (n)
  • 89.45 (a)
(Monodelphis domestica)
Mammalia CASP6 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia CASP6 36
  • 68 (a)
(Gallus gallus)
Aves CASP6 35
  • 72.88 (n)
  • 72.4 (a)
CASP6 36
  • 67 (a)
(Anolis carolinensis)
Reptilia CASP6 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia casp6 35
  • 67.16 (n)
  • 68.13 (a)
Str.15354 35
African clawed frog
(Xenopus laevis)
Amphibia xCaspase-6 35
(Danio rerio)
Actinopterygii casp6 35
  • 67.04 (n)
  • 70.11 (a)
casp6 36
  • 65 (a)
casp6l1 36
  • 33 (a)
casp6l2 36
  • 52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.144 35
fruit fly
(Drosophila melanogaster)
Insecta Dcp-1 37
  • 38 (a)
decay 37
  • 34 (a)
Ice 37
  • 40 (a)
Dcp-1 36
  • 31 (a)
decay 36
  • 30 (a)
Ice 36
  • 31 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7590 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6562 36
  • 34 (a)
Species with no ortholog for CASP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASP6 Gene

Gene Tree for CASP6 (if available)
Gene Tree for CASP6 (if available)

Paralogs for CASP6 Gene

(4) SIMAP similar genes for CASP6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CASP6: view

Variants for CASP6 Gene

Sequence variations from dbSNP and Humsavar for CASP6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs768062 -- 109,698,977(-) cactt(C/T)catga intron-variant
rs768063 -- 109,699,300(-) AGTCC(A/G)TGCTT intron-variant
rs1042887 -- 109,697,656(-) GGCGG(C/G)GCACC missense, reference, intron-variant
rs1042889 -- 109,689,308(-) AATTT(C/T)ACACT utr-variant-3-prime
rs1541373 -- 109,707,738(+) CAGAA(C/T)CATGC intron-variant

Relevant External Links for CASP6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CASP6 Gene

Disorders for CASP6 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CASP6 Gene in MalaCards »

(3) Diseases for CASP6 Gene

(1) University of Copenhagen DISEASES for CASP6 Gene

(23) Novoseek inferred disease relationships for CASP6 Gene

Disease -log(P) Hits PubMed IDs
neuropil threads 61.5 6
neurofibrillary tangles 38.6 7
leukemia 37.1 1
huntington disease 35.8 1
tumors 32.3 15

Relevant External Links for CASP6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CASP6: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CASP6 Gene

Publications for CASP6 Gene

  1. Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. (PMID: 7796396) Fernandes-Alnemri T. … Alnemri E.S. (Cancer Res. 1995) 2 3 4 23
  2. Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and Ich-1, involved in cellular apoptosis. (PMID: 8780721) Tiso N. … Danieli G.A. (Biochem. Biophys. Res. Commun. 1996) 2 3 23
  3. Regulation of caspase-6 and FLIP by the AMPK family member ARK5. (PMID: 15273717) Suzuki A. … Esumi H. (Oncogene 2004) 3 4 23
  4. Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells. (PMID: 16135563) Werz O. … Steinhilber D. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 23
  5. Breaking the connection: caspase 6 disconnects intermediate filament-binding domain of periplakin from its actin-binding N-terminal region. (PMID: 15654952) Kalinin A.E. … Aho S. (J. Invest. Dermatol. 2005) 3 23

Products for CASP6 Gene

  • Addgene plasmids for CASP6

Sources for CASP6 Gene

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