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CASP5 Gene

protein-coding   GIFtS: 64
GCID: GC11M104864

Caspase 5, Apoptosis-Related Cysteine Peptidase

(Previous names: caspase 5, apoptosis-related cysteine protease)
  See CASP5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Caspase 5, Apoptosis-Related Cysteine Peptidase1 2     ICEREL-III2
Caspase 5, Apoptosis-Related Cysteine Protease1 2     ICH-32
Protease ICH-32 3     caspase-52
Protease TY2 3     TY Protease2
CASP-52 3     EC 3.4.22.583
ICE(rel)-III2 3     ICH33
ICE(rel)III2     EC 3.4.228

External Ids:    HGNC: 15061   Entrez Gene: 8382   Ensembl: ENSG000001377577   OMIM: 6026655   UniProtKB: P518783   

Export aliases for CASP5 gene to outside databases

Previous GC identifers: GC11M107058 GC11M106221 GC11M104899 GC11M104402 GC11M104370 GC11M100795


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CASP5 Gene:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of
caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes
which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small,
that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in
fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell
growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated
dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide.
Alternatively spliced transcript variants have been identified for this gene. (provided by RefSeq, Aug 2010)

GeneCards Summary for CASP5 Gene:
CASP5 (caspase 5, apoptosis-related cysteine peptidase) is a protein-coding gene. Diseases associated with CASP5 include cowpox, and myocardial infarction. GO annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type peptidase activity. An important paralog of this gene is CASP16.

UniProtKB/Swiss-Prot: CASP5_HUMAN, P51878
Function: Mediator of programmed cell death (apoptosis)

summary for CASP5 Gene:
Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of
apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and
effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with,
upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector
caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the
executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase
Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors
such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For
example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form
part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by
inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of
many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory
disease.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CASP5 gene promoter:
         C/EBPbeta   ISGF-3   AP-1   ATF-2   IRF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCASP5 promoter sequence
   Search Chromatin IP Primers for CASP5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CASP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.2-q22.3   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22.2-q22.3

CASP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CASP5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M104864:  view genomic region     (about GC identifiers)

Start:
104,864,962 bp from pter      End:
104,893,895 bp from pter
Size:
28,934 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CASP5_HUMAN, P51878 (See protein sequence)
Recommended Name: Caspase-5 precursor  
Size: 434 amino acids; 49736 Da
Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa
(p20) and a 10 kDa (p10) subunits. Interacts with MEFV
Sequence caution: Sequence=AAA75172.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH74994.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI13407.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=ABF47103.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAG59257.1; Type=Frameshift; Positions=10;
Sequence=CAA64450.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DKP5 Q0QVY7 Q0QVY8 Q0QVZ0 Q0QVZ1 Q0QVZ2 Q14DD6 Q1HBJ3 Q6DJV7
Alternative splicing, Alternative initiation: 6 isoforms:  P51878-1   P51878-2   P51878-3   P51878-4   P51878-5   P51878-6   (Produced by alternative initiation at Met-71 of isoform 1)

Explore the universe of human proteins at neXtProt for CASP5: NX_P51878

Explore proteomics data for CASP5 at MOPED

Post-translational modifications: 

  • The two subunits are derived from the precursor sequence by an autocatalytic mechanism1
  • Modification sites at neXtProt
  • Selected DME Specific Peptides for CASP5 (P51878) (see all 6)
     QMPTIER  SDSTFLV  DKPKVII  LITCFQKY 


    See CASP5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001129581.1  NP_001129582.1  NP_001129584.1  NP_004338.3  

    ENSEMBL proteins: 
     ENSP00000396053   ENSP00000260315   ENSP00000388365   ENSP00000436877   ENSP00000434471  
     ENSP00000408455   ENSP00000415241   ENSP00000376849   ENSP00000398130   ENSP00000376847  

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    antibodies-online proteins for CASP5 (8 products) 

     
    antibodies-online peptides for CASP5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CASP: Caspases

    IUPHAR Guide to PHARMACOLOGY protein family classification: Caspase 5
    Caspases

    Selected InterPro protein domains (see all 8):
     IPR001309 Pept_C14_ICE_p20
     IPR011029 DEATH-like_dom
     IPR017350 Caspase_IL-1_beta
     IPR002138 Pept_C14_p10
     IPR015917 Pept_C14A_p45_core

    Graphical View of Domain Structure for InterPro Entry P51878

    ProtoNet protein and cluster: P51878

    3 Blocks protein domains:
    IPB001309 Caspase-1
    IPB001315 CARD interaction domain
    IPB002398 Interleukin-1B converting enzyme signature


    UniProtKB/Swiss-Prot: CASP5_HUMAN, P51878
    Similarity: Belongs to the peptidase C14A family
    Similarity: Contains 1 CARD domain


    Find genes that share domains with CASP5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CASP5_HUMAN, P51878
    Function: Mediator of programmed cell death (apoptosis)
    Catalytic activity: Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of
    Tyr-Val-Ala-Asp- - but also cleaves at Asp-Glu-Val-Asp- -
    Induction: Up-regulated by bacterial lipopolysaccharides (LPS)

         Genatlas biochemistry entry for CASP5:
    caspase 5,cysteine containing aspartate-specific protease,CASP1 subfamily,potentially involved in procytokine
    activation,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic
    stimuli,promoting apoptosis,target gene in the microsatellite mutator pathway for cancer

         Enzyme Numbers (IUBMB): EC 3.4.222 EC 3.4.22.581

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IBA--
    GO:0005515protein binding ----
    GO:0008234cysteine-type peptidase activity TAS7797592
         
    Find genes that share ontologies with CASP5           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CASP5

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    Inhib. RNA
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    Sino Biological Human cDNA Clone for CASP5
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IBA--
    GO:0072557NOT IPAF inflammasome complex IBA--
    GO:0072558NLRP1 inflammasome complex IDA12191486
    GO:0072559NOT NLRP3 inflammasome complex IBA--

    Find genes that share ontologies with CASP5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CASP5 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1p53 Signaling
    p53 Signaling0.38
    p53 Pathway0.38
    2Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    NOD-like receptor signaling pathway0.37
    NOD pathway0.33
    3Ceramide Pathway
    Ceramide Pathway0.32
    TNF-Induced Apoptosis Implicating Sphingolipids0.32
    4Apoptotic Pathways in Synovial Fibroblasts
    DHA Signaling0.74
    5NOD-like Receptor Signaling Pathways
    NOD-like Receptor Signaling Pathways0.58


    Find genes that share SuperPaths with CASP5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CASP5
        NOD-like Receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CASP5 (see all 11)
        14-3-3 Induced Apoptosis
    DHA Signaling
    S-1P Stimulated Signaling
    Endothelin-1 Signaling Pathway
    TNF-Induced Apoptosis Implicating Sphingolipids

    1 Cell Signaling Technology (CST) Pathway for CASP5
        Apoptosis and Autophagy

    1 BioSystems Pathway for CASP5
        NOD pathway

    3 Sino Biological Pathways for CASP5
        EGFR Signaling Pathway
    p53 Pathway
    Death Receptor Signaling


    1 Kegg Pathway  (Kegg details for CASP5):
        NOD-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CASP5: 
              Inflammasomes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CASP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for CASP5 (P518783 ENSP000003768494) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NLRP1Q9C0003, ENSP000002692804I2D: score=2 STRING: ENSP00000269280
    MAXP612443, ENSP000003514904I2D: score=1 STRING: ENSP00000351490
    PPHLN1Q8NEY83, ENSP000003385104I2D: score=2 STRING: ENSP00000338510
    IL18Q141163I2D: score=1 
    MEFVO155533I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS7797592
    GO:0006915apoptotic process TAS7797592
    GO:0021762substantia nigra development IEP--
    GO:0042981regulation of apoptotic process IEA--
    GO:0043066negative regulation of apoptotic process ----

    Find genes that share ontologies with CASP5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CASP5
    Selected ApexBio Compounds for CASP5 (see all 12)     About this table
    CompoundAction CAS #
    Apoptosis InhibitorCell-permeable caspase-3 inhibitor[54135-60-3]
    Caspase-3/7 Inhibitor ICell-permeable and irreversible inhibitor of caspase-3 and -7[220509-74-0]
    CisplatinChemotherapy agent, induces apoptosis[15663-27-1]
    PAC-1Procaspase-activating compound, activates procaspase-3 and converts it to caspase-3[315183-21-2]
    Q-VD-OphCell-permeable, irreversible pan-caspase inhibitor[1135695-98-5]
    VX-765 Novel Caspase-1 inhibitor[273404-37-8]
    Z-DEVD-FMKCell-permeable, and irreversible caspase-3 inhibitor[210344-95-9]
    Z-DQMD-FMKCell-permeable caspase-3 inhibitor--
    Z-FA-FMKEffector caspases 2, 3, 5, and 7--
    Z-VAD-FMKCell-permeable, irreversible pan-caspase inhibitor[187389-52-2]

    Compounds for CASP5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AZ 10417808Selective non-peptide caspase-3 inhibitor[331645-84-2]
    Z-DQMD-FMKCaspase-3 inhibitor--
    CisplatinPotent pro-apoptotic anticancer agent; activates caspase-3[15663-27-1]
    Z-DEVD-FMK Cell-permeable, irreversible caspase-3 inhibitor --
    Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor [187389-52-2]

    1 IUPHAR Ligand for CASP5 (Caspase 5)    About this table
    LigandTypeActionAffinityPubmed IDs
    Z-WEHD-FMK
    InhibitorInhibition12903195

    2 Novoseek inferred chemical compound relationships for CASP5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mononucleotide 69.8 2 19787250 (1), 10383166 (1)
    cysteine 31.7 3 16465268 (1), 16886895 (1)



    Find genes that share compounds with CASP5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CASP5 gene (4 alternative transcripts): 
    NM_001136109.1  NM_001136110.1  NM_001136112.1  NM_004347.3  

    Unigene Cluster for CASP5:

    Caspase 5, apoptosis-related cysteine peptidase
    Hs.213327  [show with all ESTs]
    Unigene Representative Sequence: NM_001136112
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000438448 ENST00000260315 ENST00000444749 ENST00000526056 ENST00000531367
    ENST00000456200 ENST00000456094 ENST00000393141(uc010ruz.1 uc010rva.1 uc010rvb.1)
    ENST00000418434(uc010rvc.1 uc010rvd.1) ENST00000393139(uc009yxh.2)

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    Additional mRNA sequence: 

    AK296660.1 BC074994.2 BC113406.1 DQ228672.1 DQ228673.1 DQ228674.1 DQ228675.1 DQ228676.1 
    DQ228677.1 NR_024239.1 NR_036562.1 U28015.1 X94993.1 

    2 DOTS entries:

    DT.441751  DT.97786382 

    13 AceView cDNA sequences:

    X94993 BX108026 BC074994 BG185445 AL702880 NM_004347 U28015 BG707417 
    AW337390 AW071186 W60764 W60703 AA468693 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CASP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCCAGAAA
    CASP5 Expression
    About this image


    CASP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Heart (Cardiovascular System)
    CASP5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CASP5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.213327

    UniProtKB/Swiss-Prot: CASP5_HUMAN, P51878
    Tissue specificity: Expressed in barely detectable amounts in most tissues except brain, highest levels being
    found in lung, liver and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CASP5: 
              Inflammasomes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CASP5 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    42(a)
    1 → many
    19(705896-708766) ENSGALG00000001049
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    48(a)
    1 → many
    GL344618.1(3490-9499)
    zebrafish
    (Danio rerio)
    Actinopterygii caspb6
    caspase b
    26(a)
    many ↔ many
    1(58737275-58751108) ENSDARG00000052039
    fruit fly
    (Drosophila melanogaster)
    Insecta Nc6
    Dredd6
    Death related ced-3/Nedd2-like protein
    16(a)
    12(a)
    many ↔ many
    many ↔ many
    3L(9961579-9964102)
    X(527553-529760)
    worm
    (Caenorhabditis elegans)
    Secernentea csp-16
    Protein CSP-1, isoform a
    15(a)
    many ↔ many
    II(13601204-13605057) WBGene00000819
            Species with no ortholog for CASP5

    ENSEMBL Gene Tree for CASP5 (if available)
    TreeFam Gene Tree for CASP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CASP5 gene
    CASP162  CASP62  CASP82  CASP122  CASP92  CASP72  CASP32  CASP22  
    CASP142  CASP12  CASP102  CASP42  
    6 SIMAP similar genes for CASP5 using alignment to 4 protein entries:     CASP5_HUMAN (see all proteins):
    DKFZp586A181    mih1/Tx    LOC643733    CASP4    CASP12    CASP1

    Find genes that share paralogs with CASP5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CASP5 (see all 859)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs358706131,2
    C--104744376(+) ACACG-/TATATAT 6 -- int10--------
    rs1512100221,2
    --104864483(+) AACAAC/TGTTGC 6 -- ds50010--------
    rs1907119191,2
    --104864532(+) CTTTCA/CATTAT 6 -- ds50010--------
    rs1997202711,2
    C--104864692(+) AAACA-/CCTGTT 6 -- ds50010--------
    rs115746921,2
    C,F,H--104864751(-) GATACC/GACCTC 6 -- ds500111Minor allele frequency- G:0.06NA NS EA WA 756
    rs1403478801,2
    --104864847(+) CATGAG/TCCATA 6 -- ds50010--------
    rs31813381,2
    C,F,A,H--104864885(-) AAAATG/TAAGTG 6 -- ds500122Minor allele frequency- T:0.08NA NS EA CSA WA 2274
    rs454862971,2
    C,F--104864895(-) TGGACG/AAGTGA 6 -- ds50015Minor allele frequency- A:0.01NS 182
    rs1841545911,2
    --104864919(+) AATTAC/TATTGT 6 -- ds50010--------
    rs455878321,2
    C,F--104864966(-) TATCTT/ATTTAG 6 -- ds50017Minor allele frequency- A:0.03NS WA EA 420

    HapMap Linkage Disequilibrium report for CASP5 (104864962 - 104893895 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CASP5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv468862CNV Gain19166990
    esv2750978CNV Gain17911159
    nsv898355CNV Gain21882294

    Human Gene Mutation Database (HGMD): CASP5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CASP5
    DNA2.0 Custom Variant and Variant Library Synthesis for CASP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602665    OMIM disorders: --

    2 diseases for CASP5:    
    About MalaCards
    cowpox    myocardial infarction


    Find genes that share disorders with CASP5           About GenesLikeMe

    10 Novoseek inferred disease relationships for CASP5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    microsatellite instability 74.6 4 12531228 (1), 15088110 (1), 17676485 (1), 18430458 (1)
    cowpox 62.4 1 16465268 (1)
    colon carcinoma 40.8 1 10986288 (1)
    colorectal cancer 24.1 1 15088110 (1)
    leukemia 19 2 12479849 (1), 12531228 (1)
    colon cancer 11.7 1 12615711 (1)
    primary tumor 11.1 1 11979558 (1)
    tumors 8.37 4 15886296 (1), 10383166 (1), 11996796 (1), 15088110 (1)
    cancer lung 0 1 12964016 (1)
    cancer 0 6 18430458 (3), 15563124 (1), 10383166 (1)

    Genetic Association Database (GAD): CASP5
    Human Genome Epidemiology (HuGE) Navigator: CASP5 (16 documents)

    Export disorders for CASP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CASP5 gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with CASP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases. (PubMed id 7797592)1, 2, 3, 9 Munday N.A.... Nicholson D.W. (J. Biol. Chem. 1995)
    2. Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants. (PubMed id 16893518)1, 2, 9 Eckhart L....Tschachler E. (Biochem. Biophys. Res. Commun. 2006)
    3. Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PubMed id 16886895)1, 4, 9 Hwang Y....Chen D.S. (Pharmacogenomics 2006)
    4. Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival. (PubMed id 19270026)1, 4, 9 Quaye L.... Gayther S.A. (Hum. Mol. Genet. 2009)
    5. Evidence for depletion of CASP5 Ala90Thr heterozygous genotype in aged subjects. (PubMed id 20434535)1, 4 Ulybina Y.M....Imyanitov E.N. (Exp. Gerontol. 2010)
    6. Mutational analysis of caspase genes in prostate carcinomas. (PubMed id 20402676)1, 4 Kim M.S....Lee S.H. (APMIS 2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (amp 2010)
    9. Mutational analysis of CASP1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 14 genes in gastrointestinal stromal tumors. (PubMed id 19269008)1, 4 Kim Y.R....Lee S.H. (Hum. Pathol. 2009)
    10. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 838 HGNC: 1506 AceView: CASP5 Ensembl:ENSG00000137757 euGenes: HUgn838
    ECgene: CASP5 Kegg: 838 H-InvDB: CASP5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CASP5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CASP5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/casp5/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CASP5 gene:
    Search GeneIP for patents involving CASP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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