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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CASP5 Gene

protein-coding   GIFtS: 62
GCID: GC11M104864

caspase 5, apoptosis-related cysteine peptidase

(Previous names: caspase 5, apoptosis-related cysteine protease )
 Explore 30 diseases affiliated with
CASP5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CASP5    

Aliases
for CASP5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Caspase 5, Apoptosis-Related Cysteine Peptidase1 2     ICEREL-III2
ICE(Rel)III1     ICH-32
Caspase 5, Apoptosis-Related Cysteine Protease1 2     Caspase-51
Protease ICH-32 3     TY Protease2
Protease TY2 3     EC 3.4.22.583
CASP-52 3     ICH33
ICE(Rel)-III1     EC 3.4.228

External Ids:    HGNC: 15061   Entrez Gene: 8382   Ensembl: ENSG000001377577   OMIM: 6026655   UniProtKB: P518783   

Export aliases for CASP5 gene to outside databases

Previous GC identifers: GC11M107058 GC11M106221 GC11M104899 GC11M104402 GC11M104370 GC11M100795


Summaries
for CASP5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CASP5:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases
plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo
proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form
the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central
component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and
apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of
this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been
identified for this gene. (provided by RefSeq, Aug 2010)

UniProtKB/Swiss-Prot: CASP5_HUMAN, P51878
Function: Mediator of programmed cell death (apoptosis)

summary for CASP5:
Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of
apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and
effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with,
upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector
caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the
executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase
Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors
such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For
example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form
part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by
inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of
many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory
disease.




Genomic Views
for CASP5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CASP5 gene promoter:
         C/EBPbeta   ISGF-3   AP-1   ATF-2   IRF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CASP5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CASP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.2-q22.3   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22.2-q22.3

CASP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CASP5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M104864:  view genomic region     (about GC identifiers)

Start:
 104,864,962 bp from pter      End:
 104,893,895 bp from pter
Size:
 28,934 bases      Orientation:
 minus strand

Proteins
for CASP5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CASP5_HUMAN, P51878 (See protein sequence)
Recommended Name: Caspase-5 precursor  
Size: 434 amino acids; 49736 Da
Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and
a 10 kDa (p10) subunits
Sequence caution: Sequence=AAA75172.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH74994.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI13407.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=ABF47103.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAG59257.1; Type=Frameshift; Positions=10; Sequence=CAA64450.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DKP5 Q0QVY7 Q0QVY8 Q0QVZ0 Q0QVZ1 Q0QVZ2 Q14DD6 Q1HBJ3 Q6DJV7
Alternative splicing, Alternative initiation: 6 isoforms:  P51878-1   P51878-2   P51878-3   P51878-4   P51878-5   P51878-6   (Produced by alternative initiation at Met-71 of isoform 1)

Explore the universe of human proteins at neXtProt for CASP5: NX_P51878

Post-translational modifications:

  • The two subunits are derived from the precursor sequence by an autocatalytic mechanism1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51878

    • 4/6 DME Specific Peptides for CASP5 (P51878) (see all 6)
     QMPTIER  SDSTFLV  DKPKVII  LITCFQKY 

    CASP5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001129581.1  NP_001129582.1  NP_001129584.1  NP_004338.3  

    ENSEMBL proteins: 
     ENSP00000396053   ENSP00000260315   ENSP00000388365   ENSP00000436877   ENSP00000434471  
     ENSP00000408455   ENSP00000415241   ENSP00000376849   ENSP00000398130   ENSP00000376847  

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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CASP5

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0072558NLRP1 inflammasome complex IDA12191486


    CASP5 for ontologies           About GeneDecksing



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    Enzo Life Sciences assays for CASP5
    Uscn ELISAs and CLIAs for CASP5

    Protein Domains /
    Families
    for CASP5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CASP5 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR001309 Pept_C14_ICE_p20
     IPR011029 DEATH-like_dom
     IPR017350 Caspase_IL-1_beta
     IPR002138 Pept_C14_p10
     IPR015917 Pept_C14_p45_core

    Graphical View of Domain Structure for InterPro Entry P51878

    ProtoNet protein and cluster: P51878

    3 Blocks protein families:
    IPB001309 Caspase-1
    IPB001315 CARD interaction domain
    IPB002398 Interleukin-1B converting enzyme signature


    UniProtKB/Swiss-Prot: CASP5_HUMAN, P51878
    Similarity: Belongs to the peptidase C14A family
    Similarity: Contains 1 CARD domain


    Function
    for CASP5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CASP5_HUMAN, P51878
    Function: Mediator of programmed cell death (apoptosis)
    Catalytic activity: Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of
    Tyr-Val-Ala-Asp- - but also cleaves at Asp-Glu-Val-Asp- -
    Induction: Up-regulated by bacterial lipopolysaccharides (LPS)

         Genatlas biochemistry entry for CASP5:
    caspase 5,cysteine containing aspartate-specific protease,CASP1 subfamily,potentially involved in procytokine
    activation,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic
    stimuli,promoting apoptosis,target gene in the microsatellite mutator pathway for cancer

    Enzyme Numbers (IUBMB): EC 3.4.222 EC 3.4.22.581

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for CASP5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP5

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IEA--
    GO:0008234cysteine-type peptidase activity TAS7797592


    CASP5 for ontologies           About GeneDecksing



    Pathways & Interactions
    for CASP5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TNF-Induced Apoptosis Implicating Sphingolipids
    		TNF-Induced Apoptosis Implicating Sphingolipids1.00
    		Ceramide Pathway0.32
    2Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    		NOD-like receptor signaling pathway0.36
    		NOD pathway0.23
    3Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    4S-1P Stimulated Signaling
    		S-1P Stimulated Signaling1.00
    514-3-3 Induced Apoptosis
    		14-3-3 Induced Apoptosis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CASP5 (see all 11)
        14-3-3 Induced Apoptosis
    DHA Signaling
    S-1P Stimulated Signaling
    Endothelin-1 Signaling Pathway
    TNF-Induced Apoptosis Implicating Sphingolipids

    1 Cell Signaling Technology (CST) Pathway for CASP5
        Apoptosis and Autophagy

    1 BioSystems Pathway for CASP5 
        NOD pathway


    1         Kegg Pathway  (Kegg details for CASP5):
        NOD-like receptor signaling pathway


    CASP5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CASP5

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for CASP5 (P518783 ENSP000003768494) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NLRP1Q9C0003, ENSP000002692804I2D: score=2 STRING: ENSP00000269280
    MAXP612443, ENSP000003514904I2D: score=1 STRING: ENSP00000351490
    PPHLN1Q8NEY83, ENSP000003385104I2D: score=2 STRING: ENSP00000338510
    IL18Q141163I2D: score=1 
    MEFVO155533I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0006915apoptotic process IEA--
    GO:0042981regulation of apoptotic process IEA--
    GO:0043066negative regulation of apoptotic process ----
    GO:0071260cellular response to mechanical stimulus IEP19593445


    CASP5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CASP5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CASP5 for compounds           About GeneDecksing

    EMD Millipore small molecules for CASP5:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for CASP5

    Compounds for CASP5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Z-WEHD-FMKCaspase-5 inhibitor--
    Ac-LEHD-AFCFluorogenic caspase substrate[210345-03-2]
    Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor --
    2 Novoseek chemical compound relationships for CASP5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mononucleotide 69.8 2 19787250 (1), 10383166 (1)
    cysteine 31.7 3 16465268 (1), 16886895 (1)

    Search CenterWatch for drugs/clinical trials and news about CASP5 

    Transcripts
    for CASP5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CASP5 gene (4 alternative transcripts): 
    NM_001136109.1  NM_001136110.1  NM_001136112.1  NM_004347.3  

    Unigene Cluster for CASP5:

    Caspase 5, apoptosis-related cysteine peptidase
    Hs.213327  [show with all ESTs]
    Unigene Representative Sequence: NM_001136112
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000438448 ENST00000260315 ENST00000444749 ENST00000526056 ENST00000531367
    ENST00000456200 ENST00000456094 ENST00000393141(uc010ruz.1 uc010rva.1 uc010rvb.1)
    ENST00000418434(uc010rvc.1 uc010rvd.1) ENST00000393139(uc009yxh.2)


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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK296660.1 BC074994.2 BC113406.1 DQ228672.1 DQ228673.1 DQ228674.1 DQ228675.1 DQ228676.1 
    DQ228677.1 NR_024239.1 NR_036562.1 U28015.1 X94993.1 

    2 DOTS entries:

    DT.441751  DT.97786382 

    13 AceView cDNA sequences:

    BC074994 BX108026 X94993 AL702880 BG185445 NM_004347 U28015 BG707417 
    W60764 AW337390 AW071186 W60703 AA468693 

    GeneLoc Exon Structure


    Expression
    for CASP5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CASP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTCCAGAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CASP5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CASP5

    SOURCE GeneReport for Unigene cluster: Hs.213327

    UniProtKB/Swiss-Prot: CASP5_HUMAN, P51878
    Tissue specificity: Expressed in barely detectable amounts in most tissues except brain, highest levels being found in
    lung, liver and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including CASP5: 
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              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP5

    Orthologs
    for CASP5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CASP5 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1P0X7_CHICK6
    		 caspase 1
    		 38(a)
    		 1 → many
    		 19(644765-649090)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 47(a)
    		 1 → many
    		 GL344618.1(3490-9499)
    zebrafish
    (Danio rerio)    		 Actinopterygii caspa6
    zgc:1717316
    (see all 5)    		 zgc:171731
    (see all 5)    		 29(a)
    27(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 16(44763011-44774004)
    7(20757858-20762495)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Nc6
    Dredd6
    		 Death related ced-3/Nedd2-like protein
    		 11(a)
    11(a)
    		 possible ortholog
    1 ↔ many
    		 3L(9961579-9964102)
    X(527553-529760)
    worm
    (Caenorhabditis elegans)    		 Secernentea csp-26
    ced-36
    (see all 4)    		 CaSPase family member (csp-2)
    Cell death protein 3 Cell death protein 3 subunit ...
    (see all 4)    		 7(a)
    17(a)
    (see all 4)    		 possible ortholog
    possible ortholog
    (see all 4)    		 IV(6307728-6315708)
    IV(13199206-13206272)


    ENSEMBL Gene Tree for CASP5 (if available)
    TreeFam Gene Tree for CASP5 (if available) 

    Paralogs
    for CASP5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CASP5 gene
    CASP162  CASP62  CASP82  CASP122  CASP92  CASP72  CASP32  CASP22  
    CASP142  CASP12  CASP102  CASP42  
    6 SIMAP similar genes for CASP5 using alignment to 4 protein entries:     CASP5_HUMAN (see all proteins):
    DKFZp586A181    mih1/Tx    LOC643733    CASP4    CASP12    CASP1

    CASP5 for paralogs           About GeneDecksing



    Genomic Variants
    for CASP5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/688 NCBI SNPs in CASP5 are shown (see all 688)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1512100221,2
    		--104864483(+) AACAAC/TGTTGC 6 -- ds50010--------
    rs1907119191,2
    		--104864532(+) CTTTCA/CATTAT 6 -- ds50010--------
    rs1997202711,2
    		--104864692(+) AAACA-/CCTGTT 6 -- ds50010--------
    rs115746921,2
    		C,F,H,--104864751(-) GATACC/GACCTC 6 -- ds500111Minor allele frequency- G:0.06NA NS EA WA 756
    rs1403478801,2
    		--104864847(+) CATGAG/TCCATA 6 -- ds50010--------
    rs31813381,2
    		C,F,A,H,--104864885(-) AAAATG/TAAGTG 6 -- ds500122Minor allele frequency- T:0.08NA NS EA CSA WA 2274
    rs454862971,2
    		C,--104864895(-) TGGACG/AAGTGA 6 -- ds50015Minor allele frequency- A:0.01NS 182
    rs1841545911,2
    		--104864919(+) AATTAC/TATTGT 6 -- ds50010--------
    rs455878321,2
    		C,F,--104864966(-) TATCTT/ATTTAG 6 -- ds50017Minor allele frequency- A:0.03NS WA EA 420
    rs455275331,2
    		C,--104865169(-) AAGCAT/CATGGC 6 -- int15Minor allele frequency- C:0.00NS 188

    HapMap Linkage Disequilibrium report for CASP5 (104864962 - 104893895 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CASP5
         1 CNV: 8695
    Human Gene Mutation Database (HGMD): CASP5

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CASP5

    Disorders / Diseases
    for CASP5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CASP5 for disorders           About GeneDecksing

    OMIM gene information: 602665    OMIM disorders: --

    20/30 diseases for CASP5 (see all 30):    About MalaCards
    non-hodgkin lymphoma    gastrointestinal stromal tumor    cowpox    leukemia/lymphoma
    leukemia/lymphoma, t-cell    hodgkin's lymphoma    chronic lymphocytic leukemia    epithelial ovarian cancer
    lymphocytic leukemia    colorectal cancer    lymphoblastic lymphoma    colon carcinoma
    myelodysplastic syndrome    colon cancer    multiple sclerosis    hepatitis c
    leukemia    ovarian cancer    hepatitis b    endometrial cancer

    10 Novoseek disease relationships for CASP5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    microsatellite instability 74.6 4 12531228 (1), 15088110 (1), 17676485 (1), 18430458 (1)
    cowpox 62.4 1 16465268 (1)
    colon carcinoma 40.8 1 10986288 (1)
    colorectal cancer 24.1 1 15088110 (1)
    leukemia 19 2 12479849 (1), 12531228 (1)
    colon cancer 11.7 1 12615711 (1)
    primary tumor 11.1 1 11979558 (1)
    tumors 8.37 4 15886296 (1), 10383166 (1), 11996796 (1), 15088110 (1)
    cancer lung 0 1 12964016 (1)
    cancer 0 6 18430458 (3), 15563124 (1), 10383166 (1)

    Human Genome Epidemiology (HuGE) Navigator: CASP5 (16 documents)

    Export disorders for CASP5 gene to outside databases

    Publications
    for CASP5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CASP5 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with CASP5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases. (PubMed id 7797592)1, 2, 3, 9 Munday N.A.... Nicholson D.W. (1995)
    2. Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants. (PubMed id 16893518)1, 2, 9 Eckhart L....Tschachler E. (2006)
    3. Interleukin-1beta-converting enzyme (ICE) and related cell death genes ICErel-II and ICErel-III map to the same PAC clone at band 11q22.2-22.3. (PubMed id 9250871)1, 3 Nasir J....Hayden M.R. (1997)
    4. Identification of a cysteine protease closely related to interleukin- 1 beta-converting enzyme. (PubMed id 8617266)1, 2 Faucheu C....Diu-Hercend A. (1996)
    5. Targeting of the transcription factor Max during apoptosis: phosphorylation-regulated cleavage by caspase-5 at an unusual glutamic acid residue in position P1. (PubMed id 11535131)1, 9 Krippner-Heidenreich A....Luscher B. (2001)
    6. Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma. (PubMed id 10986288)1, 9 Lin X.Y....Porter A.G. (2000)
    7. Mutational analysis of caspase 1, 4, and 5 genes in common human cancers. (PubMed id 18430458)1, 9 Soung Y.H....Lee S.H. (2008)
    8. TGF-betaRII, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 alterations are not associated with microsatellite instability or p53 mutations in invasive urothelial carcinoma of the urinary bladder. (PubMed id 17676485)1, 9 Saetta A.A....Patsouris E. (2007)
    9. Repeated sequences in CASPASE-5 and FANCD2 but not NF1 are targets for mutation in microsatellite-unstable acute leukemia/myelodysplastic syndrome. (PubMed id 15886296)1, 9 Offman J....Karran P. (2005)
    10. Microsatellite mutations of transforming growth factor-beta receptor type II and caspase-5 occur in human precursor T-cell lymphoblastic lymphomas/leukemias in vivo but are not associated with hMSH2 or hMLH1 promoter methylation. (PubMed id 12479849)1, 9 Scott S....DeCoteau J.F. (2003)

    External Searches for CASP5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CASP5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 838 HGNC: 1506 AceView: CASP5 Ensembl:ENSG00000137757 euGenes: HUgn838
    ECgene: CASP5 Kegg: 838 H-InvDB: CASP5

    Other Databases showing CASP5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CASP5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CASP5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CASP5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/casp5/

    Intellectual Property
    for CASP5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CASP5 gene:
    Search GeneIP for patents involving CASP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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