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CASP5 Gene(Protein Coding)

Caspase 5

GCID:
GC11M104995
GIFtS:
64
Genes Participants
UDN Logo

Aliases for CASP5 Gene

Aliases for CASP5 Gene

  • Caspase 5 2 3 5
  • Caspase 5, Apoptosis-Related Cysteine Peptidase 2 3
  • Caspase 5, Apoptosis-Related Cysteine Protease 2 3
  • Protease ICH-3 3 4
  • ICE(Rel)-III 3 4
  • Protease TY 3 4
  • CASP-5 3 4
  • EC 3.4.22.58 4
  • TY Protease 3
  • ICE(Rel)III 3
  • ICEREL-III 3
  • Caspase-5 3
  • EC 3.4.22 61
  • ICH-3 3
  • ICH3 4

External Ids for CASP5 Gene

Previous GeneCards Identifiers for CASP5 Gene

  • GC11M107058
  • GC11M106221
  • GC11M104899
  • GC11M104402
  • GC11M104370
  • GC11M104864
  • GC11M100795

Summaries for CASP5 Gene

Entrez Gene Summary for CASP5 Gene

  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for CASP5 Gene

CASP5 (Caspase 5) is a Protein Coding gene. Diseases associated with CASP5 include Cowpox. Among its related pathways are TRAF Pathway and Development ERBB-family signaling. GO annotations related to this gene include cysteine-type endopeptidase activity and scaffold protein binding. An important paralog of this gene is CASP4.

UniProtKB/Swiss-Prot for CASP5 Gene

  • Mediator of programmed cell death (apoptosis).

Tocris Summary for CASP5 Gene

  • Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP5 Gene

Genomics for CASP5 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CASP5 Gene

Enhancers for CASP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G105032 1.4 FANTOM5 ENCODE dbSUPER 13.4 -11.1 -11102 3.7 CTCF TBP TAF1 CEBPB JUNB MAX CEBPG RAD21 YY1 JUND CARD17 CASP4 CASP5 CARD16 CASP1P2 CASP1
GH11G105043 1.5 FANTOM5 ENCODE dbSUPER 11.4 -22.8 -22813 4.6 FOXA2 ATF1 MLX ARID4B DMAP1 BRCA1 YY1 GATA2 FOS SP5 CASP5 CARD17 CARD16 CASP1 CASP1P2
GH11G104965 1.2 FANTOM5 ENCODE 11.8 +55.5 55484 4.9 ELF3 TBP ARID4B BRCA1 ZNF48 RAD21 YY1 GATA2 FOS ETV6 CASP4 LOC643733 CASP5 CASP12 CARD17 CARD16
GH11G105164 0.8 FANTOM5 12.5 -141.2 -141208 0.5 TAF1 MAX CEBPG RAD21 YY1 IKZF1 CEBPA HNF4A ZBTB33 CARD17 CASP5 CASP4 CASP1P2 CARD16 LOC105369469 GC11M105194
GH11G105000 0.6 ENCODE 12.3 +22.2 22223 0.2 CTCF TRIM22 MAX RAD21 TARDBP SMC3 ZNF143 IRF1 MYC CASP5 CASP1 CASP4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CASP5 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CASP5 gene promoter:

Genomic Location for CASP5 Gene

Chromosome:
11
Start:
104,992,633 bp from pter
End:
105,023,221 bp from pter
Size:
30,589 bases
Orientation:
Minus strand

Genomic View for CASP5 Gene

Genes around CASP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASP5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CASP5 Gene

Proteins for CASP5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CASP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51878-CASP5_HUMAN
    Recommended name:
    Caspase-5
    Protein Accession:
    P51878
    Secondary Accessions:
    • B4DKP5
    • Q0QVY7
    • Q0QVY8
    • Q0QVZ0
    • Q0QVZ1
    • Q0QVZ2
    • Q14DD6
    • Q1HBJ3
    • Q6DJV7

    Protein attributes for CASP5 Gene

    Size:
    434 amino acids
    Molecular mass:
    49736 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunits. Interacts with MEFV.
    SequenceCaution:
    • Sequence=AAA75172.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH74994.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI13407.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=ABF47103.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG59257.1; Type=Frameshift; Positions=10; Evidence={ECO:0000305}; Sequence=CAA64450.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CASP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CASP5 Gene

Protein Expression for CASP5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CASP5 Gene

P51878:
  • SSTPHNVSWR
  • LITCFQKY
  • DKPKVII
  • SDSTFLV
  • EKDFIAFCSSTP
  • QMPTIER

Post-translational modifications for CASP5 Gene

  • The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CASP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CASP5 (CASP5)
  • Cloud-Clone Corp. Antibodies for CASP5

Assay Products

  • Enzo Life Sciences assays for CASP5
  • Cloud-Clone Corp Assay Kits for CASP5

Domains & Families for CASP5 Gene

Gene Families for CASP5 Gene

HGNC:
IUPHAR :

Protein Domains for CASP5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CASP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51878

UniProtKB/Swiss-Prot:

CASP5_HUMAN :
  • Belongs to the peptidase C14A family.
Family:
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP5: view

Function for CASP5 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CASP5 Gene

GENATLAS Biochemistry:
caspase 5,cysteine containing aspartate-specific protease,CASP1 subfamily,potentially involved in procytokine activation,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,promoting apoptosis,target gene in the microsatellite mutator pathway for cancer
UniProtKB/Swiss-Prot CatalyticActivity:
Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp- - but also cleaves at Asp-Glu-Val-Asp- -.
UniProtKB/Swiss-Prot Function:
Mediator of programmed cell death (apoptosis).
UniProtKB/Swiss-Prot Induction:
Up-regulated by bacterial lipopolysaccharides (LPS).

Enzyme Numbers (IUBMB) for CASP5 Gene

Gene Ontology (GO) - Molecular Function for CASP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity TAS 7797592
GO:0016787 hydrolase activity IEA --
GO:0097110 scaffold protein binding IEA --
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA --
genes like me logo Genes that share ontologies with CASP5: view
genes like me logo Genes that share phenotypes with CASP5: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CASP5 Gene

Localization for CASP5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CASP5 gene
Compartment Confidence
cytosol 5
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CASP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043005 neuron projection IEA --
GO:0043025 neuronal cell body IEA --
GO:0043234 protein complex IEA --
GO:0072557 NOT IPAF inflammasome complex IBA --
GO:0072558 NLRP1 inflammasome complex IDA 12191486
genes like me logo Genes that share ontologies with CASP5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CASP5 Gene

Pathways & Interactions for CASP5 Gene

genes like me logo Genes that share pathways with CASP5: view

Pathways by source for CASP5 Gene

3 Sino Biological pathways for CASP5 Gene
1 GeneTex pathway for CASP5 Gene
1 Cell Signaling Technology pathway for CASP5 Gene
1 BioSystems pathway for CASP5 Gene
1 KEGG pathway for CASP5 Gene
1 R&D Systems pathway for CASP5 Gene

Gene Ontology (GO) - Biological Process for CASP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,TAS --
GO:0006915 apoptotic process TAS 7797592
GO:0021762 substantia nigra development IEP 22926577
GO:0035234 ectopic germ cell programmed cell death IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with CASP5: view

No data available for SIGNOR curated interactions for CASP5 Gene

Drugs & Compounds for CASP5 Gene

Products:

  1. Drug

(8) Drugs for CASP5 Gene - From: ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Z-WEHD-FMK Pharma Inhibition, Inhibitor Caspase 5 inhibitor,potent,cell-permeable and irreversible 0
Caspase Inhibitor Set I Pharma Caspase Inhibitors 0
Q-VD(OMe)-OPh Pharma Pan-caspase inhibitor 0
Z-FA-FMK Pharma Cysteine proteases inhibitor 0
z-VAD-fmk Pharma Cell-permeable, irreversible pan-caspase inhibitor 0

(2) Additional Compounds for CASP5 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
MG 101
110044-82-1

(3) Tocris Compounds for CASP5 Gene

Compound Action Cas Number
MDL 28170 Potent, selective calpain and cathepsin B inhibitor 88191-84-8
MG 101 Calpain inhibitor; activates p53-dependent apoptosis 110044-82-1
PD 150606 Cell permeable calpain inhibitor 179528-45-1

(5) ApexBio Compounds for CASP5 Gene

Compound Action Cas Number
Caspase Inhibitor Set I Caspase Inhibitors
Q-VD(OMe)-OPh Pan-caspase inhibitor
Z-FA-FMK Cysteine proteases inhibitor
Z-VAD-FMK Cell-permeable, irreversible pan-caspase inhibitor 187389-52-2
Z-WEHD-FMK Caspase 5 inhibitor,potent,cell-permeable and irreversible 210345-00-9
genes like me logo Genes that share compounds with CASP5: view

Drug Products

Transcripts for CASP5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CASP5 Gene

(5) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CASP5 Gene

Caspase 5, apoptosis-related cysteine peptidase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CASP5 Gene

No ASD Table

Relevant External Links for CASP5 Gene

GeneLoc Exon Structure for
CASP5
ECgene alternative splicing isoforms for
CASP5

Expression for CASP5 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CASP5 Gene

mRNA expression in normal human tissues for CASP5 Gene
mRNA expression by BioGPS for CASP5 GenemRNA expression by GTEx for CASP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CASP5 Gene

This gene is overexpressed in Whole Blood (x23.7), Colon - Transverse (x11.3), and Small Intestine - Terminal Ileum (x8.9).

Protein differential expression in normal tissues from HIPED for CASP5 Gene

This gene is overexpressed in Plasma (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CASP5 Gene



Protein tissue co-expression partners for CASP5 Gene

NURSA nuclear receptor signaling pathways regulating expression of CASP5 Gene:

CASP5

SOURCE GeneReport for Unigene cluster for CASP5 Gene:

Hs.213327

mRNA Expression by UniProt/SwissProt for CASP5 Gene:

P51878-CASP5_HUMAN
Tissue specificity: Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle.

Evidence on tissue expression from TISSUES for CASP5 Gene

  • Intestine(4.4)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with CASP5: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CASP5 Gene

Orthologs for CASP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CASP5 34 35
  • 99.08 (n)
cow
(Bos Taurus)
 Mammalia CASP13 35
  • 68 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Casp4 35
  • 54 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia CASP4 35
  • 50 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 47 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 17 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves -- 35
  • 42 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 48 (a)
 OneToMany
zebrafish
(Danio rerio)
 Actinopterygii caspb 35
  • 26 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta Nc 35
  • 16 (a)
 ManyToMany
Dredd 35
  • 12 (a)
 ManyToMany
worm
(Caenorhabditis elegans)
 Secernentea csp-1 35
  • 15 (a)
 ManyToMany
Species where no ortholog for CASP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CASP5 Gene

ENSEMBL:
Gene Tree for CASP5 (if available)
TreeFam:
Gene Tree for CASP5 (if available)

Paralogs for CASP5 Gene

Paralogs for CASP5 Gene

(6) SIMAP similar genes for CASP5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CASP5: view

Variants for CASP5 Gene

Sequence variations from dbSNP and Humsavar for CASP5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000142979 -- 104,997,655(+) GCTGG(C/G)AAAGG intron-variant
rs1000144673 -- 105,001,060(+) CCTTC(C/T)GGTAG intron-variant
rs1000216970 -- 105,015,955(+) CCTTA(C/G)AGTGA intron-variant
rs1000235164 -- 105,003,734(+) GACTT(C/T)CTGCT intron-variant
rs1000278217 -- 105,021,438(+) AATCT(A/G)CAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CASP5 Gene

Variant ID Type Subtype PubMed ID
esv2750978 CNV gain 17911159
nsv1038877 CNV gain 25217958
nsv1041081 CNV loss 25217958
nsv1046098 CNV loss 25217958
nsv1052674 CNV loss 25217958
nsv1153818 CNV duplication 26484159
nsv468862 CNV gain 19166990
nsv556218 CNV gain 21841781
nsv556219 CNV loss 21841781

Variation tolerance for CASP5 Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CASP5 Gene

Human Gene Mutation Database (HGMD)
CASP5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CASP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASP5 Gene

Disorders for CASP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CASP5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cowpox
  • yaba
- elite association - COSMIC cancer census association via MalaCards
Search CASP5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CASP5

Genetic Association Database (GAD)
CASP5
Human Genome Epidemiology (HuGE) Navigator
CASP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CASP5
genes like me logo Genes that share disorders with CASP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CASP5 Gene

Publications for CASP5 Gene

  1. Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases. (PMID: 7797592) Munday N.A. … Nicholson D.W. (J. Biol. Chem. 1995) 2 3 4 22 64
  2. Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival. (PMID: 19270026) Quaye L. … Gayther S.A. (Hum. Mol. Genet. 2009) 3 22 46 64
  3. Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants. (PMID: 16893518) Eckhart L. … Tschachler E. (Biochem. Biophys. Res. Commun. 2006) 3 4 22 64
  4. Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PMID: 16886895) Hwang Y. … Chen D.S. (Pharmacogenomics 2006) 3 22 46 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for CASP5 Gene

  • Cloud-Clone Corp. Antibodies for CASP5
  • Cloud-Clone Corp. Proteins for CASP5
  • Cloud-Clone Corp Assay Kits for CASP5

Sources for CASP5 Gene

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