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Aliases for CASP5 Gene

Aliases for CASP5 Gene

  • Caspase 5, Apoptosis-Related Cysteine Peptidase 2 3
  • Caspase 5, Apoptosis-Related Cysteine Protease 2 3
  • Protease ICH-3 3 4
  • ICE(Rel)-III 3 4
  • Protease TY 3 4
  • CASP-5 3 4
  • EC 4
  • TY Protease 3
  • ICE(Rel)III 3
  • Caspase-5 3
  • EC 3.4.22 63
  • ICH-3 3
  • ICH3 4

External Ids for CASP5 Gene

Previous GeneCards Identifiers for CASP5 Gene

  • GC11M107058
  • GC11M106221
  • GC11M104899
  • GC11M104402
  • GC11M104370
  • GC11M104864
  • GC11M100795

Summaries for CASP5 Gene

Entrez Gene Summary for CASP5 Gene

  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for CASP5 Gene

CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase) is a Protein Coding gene. Diseases associated with CASP5 include cowpox and myocardial infarction. Among its related pathways are PAK Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include cysteine-type peptidase activity and cysteine-type endopeptidase activity. An important paralog of this gene is CASP1.

UniProtKB/Swiss-Prot for CASP5 Gene

  • Mediator of programmed cell death (apoptosis)

Tocris Summary for CASP5 Gene

  • Caspases (short for �cysteinyl aspartate proteases�) are involved in the signal transduction pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory disease.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP5 Gene

Genomics for CASP5 Gene

Regulatory Elements for CASP5 Gene

Genomic Location for CASP5 Gene

104,994,235 bp from pter
105,023,168 bp from pter
28,934 bases
Minus strand

Genomic View for CASP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CASP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP5 Gene

Proteins for CASP5 Gene

  • Protein details for CASP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DKP5
    • Q0QVY7
    • Q0QVY8
    • Q0QVZ0
    • Q0QVZ1
    • Q0QVZ2
    • Q14DD6
    • Q1HBJ3
    • Q6DJV7

    Protein attributes for CASP5 Gene

    434 amino acids
    Molecular mass:
    49736 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunits. Interacts with MEFV.
    • Sequence=AAA75172.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH74994.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI13407.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=ABF47103.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG59257.1; Type=Frameshift; Positions=10; Evidence={ECO:0000305}; Sequence=CAA64450.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CASP5 Gene

neXtProt entry for CASP5 Gene

Proteomics data for CASP5 Gene at MOPED

Selected DME Specific Peptides for CASP5 Gene

Post-translational modifications for CASP5 Gene

  • The two subunits are derived from the precursor sequence by an autocatalytic mechanism
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for CASP5 Gene

Gene Families for CASP5 Gene


Suggested Antigen Peptide Sequences for CASP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P51878
  • Contains 1 CARD domain.
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP5: view

Function for CASP5 Gene

Molecular function for CASP5 Gene

GENATLAS Biochemistry: caspase 5,cysteine containing aspartate-specific protease,CASP1 subfamily,potentially involved in procytokine activation,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,promoting apoptosis,target gene in the microsatellite mutator pathway for cancer
UniProtKB/Swiss-Prot CatalyticActivity: Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp- - but also cleaves at Asp-Glu-Val-Asp- -
UniProtKB/Swiss-Prot Function: Mediator of programmed cell death (apoptosis)
UniProtKB/Swiss-Prot Induction: Up-regulated by bacterial lipopolysaccharides (LPS).

Enzyme Numbers (IUBMB) for CASP5 Gene

Gene Ontology (GO) - Molecular Function for CASP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity --
GO:0005515 protein binding --
GO:0008234 cysteine-type peptidase activity TAS 7797592
GO:0097110 scaffold protein binding IEA --
GO:0097200 NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA --
genes like me logo Genes that share ontologies with CASP5: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CASP5 Gene

Localization for CASP5 Gene

Subcellular locations from

Jensen Localization Image for CASP5 Gene COMPARTMENTS Subcellular localization image for CASP5 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CASP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0043005 neuron projection IEA --
GO:0043025 neuronal cell body IEA --
GO:0043234 protein complex --
GO:0072557 NOT IPAF inflammasome complex IBA --
genes like me logo Genes that share ontologies with CASP5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CASP5 Gene

Pathways for CASP5 Gene

genes like me logo Genes that share pathways with CASP5: view

Pathways by source for CASP5 Gene

3 Sino Biological pathways for CASP5 Gene
1 Cell Signaling Technology pathway for CASP5 Gene
1 BioSystems pathway for CASP5 Gene
1 KEGG pathway for CASP5 Gene
1 R&D Systems pathway for CASP5 Gene

Gene Ontology (GO) - Biological Process for CASP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006915 apoptotic process TAS 7797592
GO:0021762 substantia nigra development IEP 22926577
GO:0035234 ectopic germ cell programmed cell death IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with CASP5: view

Compounds for CASP5 Gene

(12) ApexBio Compounds for CASP5 Gene

Compound Action Cas Number
Apoptosis Inhibitor Cell-permeable caspase-3 inhibitor [54135-60-3]
Caspase-3/7 Inhibitor I Cell-permeable and irreversible inhibitor of caspase-3 and -7 [220509-74-0]
Cisplatin Chemotherapy agent, induces apoptosis [15663-27-1]
PAC-1 Procaspase-activating compound, activates procaspase-3 and converts it to caspase-3 [315183-21-2]
Q-VD-Oph Cell-permeable, irreversible pan-caspase inhibitor [1135695-98-5]
VX-765 Novel Caspase-1 inhibitor [273404-37-8]
Z-DEVD-FMK Cell-permeable, and irreversible caspase-3 inhibitor [210344-95-9]
Z-DQMD-FMK Cell-permeable caspase-3 inhibitor
Z-FA-FMK An inhibitor of cysteine proteases, such as cathepsin B.
Z-VAD-FMK Cell-permeable, irreversible pan-caspase inhibitor [187389-52-2]
Z-VDVAD-FMK Cell-permeable and irreversible caspase-2 inhibitor
Z-VEID-FMK Cell-permeable and irreversible caspase-6 inhibitor

(5) Tocris Compounds for CASP5 Gene

Compound Action Cas Number
Ac-LEHD-AFC Fluorogenic caspase substrate [210345-03-2]
Cisplatin Potent pro-apoptotic anticancer agent; activates caspase-3 [15663-27-1]
Z-DQMD-FMK Caspase-3 inhibitor
Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor [187389-52-2]
Z-VDVAD-FMK Irreversible caspase-2 inhibitor

(1) IUPHAR Ligand for CASP5 Gene

Ligand Type Action Affinity Pubmed IDs
Z-WEHD-FMK Inhibitor Inhibition

(2) Novoseek inferred chemical compound relationships for CASP5 Gene

Compound -log(P) Hits PubMed IDs
mononucleotide 69.8 2
cysteine 31.7 2
genes like me logo Genes that share compounds with CASP5: view

Transcripts for CASP5 Gene

Unigene Clusters for CASP5 Gene

Caspase 5, apoptosis-related cysteine peptidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CASP5 Gene

No ASD Table

Relevant External Links for CASP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CASP5 Gene

mRNA expression in normal human tissues for CASP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CASP5 Gene

This gene is overexpressed in Whole Blood (23.7), Colon - Transverse (11.3), and Small Intestine - Terminal Ileum (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CASP5 Gene

SOURCE GeneReport for Unigene cluster for CASP5 Gene Hs.213327

mRNA Expression by UniProt/SwissProt for CASP5 Gene

Tissue specificity: Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle
genes like me logo Genes that share expressions with CASP5: view

Orthologs for CASP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CASP5 35
  • 99.08 (n)
  • 97.8 (a)
CASP5 36
  • 98 (a)
(Bos Taurus)
Mammalia CASP13 36
  • 68 (a)
(Canis familiaris)
Mammalia CASP4 36
  • 50 (a)
(Mus musculus)
Mammalia Casp4 36
  • 54 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 17 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
(Gallus gallus)
Aves -- 36
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
(Danio rerio)
Actinopterygii caspb 36
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dredd 36
  • 12 (a)
Nc 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea csp-1 36
  • 15 (a)
Species with no ortholog for CASP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CASP5 Gene

Gene Tree for CASP5 (if available)
Gene Tree for CASP5 (if available)

Paralogs for CASP5 Gene

Selected SIMAP similar genes for CASP5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CASP5: view

Variants for CASP5 Gene

Sequence variations from dbSNP and Humsavar for CASP5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs486576 -- 105,012,261(+) atctg(C/T)cacca intron-variant
rs491135 -- 105,022,196(+) GGGAG(A/G)TATAC intron-variant
rs491191 -- 105,014,420(+) TCCAG(C/T)CTAAT intron-variant
rs492859 -- 105,014,585(+) CCCAA(A/C)TCTTG intron-variant
rs492981 -- 105,014,624(+) TTGAT(G/T)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CASP5 Gene

Variant ID Type Subtype PubMed ID
esv2750978 CNV Gain 17911159
nsv898355 CNV Gain 21882294
nsv468862 CNV Gain 19166990

Relevant External Links for CASP5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASP5 Gene

Disorders for CASP5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CASP5 Gene including...

Search for CASP5 Gene in MalaCards »

(10) Novoseek inferred disease relationships for CASP5 Gene

Disease -log(P) Hits PubMed IDs
microsatellite instability 74.6 4
cowpox 62.4 1
colon carcinoma 40.8 1
colorectal cancer 24.1 1
leukemia 19 2

Relevant External Links for CASP5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CASP5: view

No data available for UniProtKB/Swiss-Prot for CASP5 Gene

Publications for CASP5 Gene

  1. Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases. (PMID: 7797592) Munday N.A. … Nicholson D.W. (J. Biol. Chem. 1995) 2 3 4 23
  2. Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PMID: 16886895) Hwang Y. … Chen D.S. (Pharmacogenomics 2006) 3 23 48
  3. Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants. (PMID: 16893518) Eckhart L. … Tschachler E. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  4. Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival. (PMID: 19270026) Quaye L. … Gayther S.A. (Hum. Mol. Genet. 2009) 3 23 48
  5. Mutational analysis of caspase 1, 4, and 5 genes in common human cancers. (PMID: 18430458) Soung Y.H. … Lee S.H. (Hum. Pathol. 2008) 3 23

Products for CASP5 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Apoptosis in human,mouse,rat
    • Apoptosis 384HT in human,mouse,rat
    • Inflammasomes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CASP5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CASP5
    • Block miRNA regulation of CASP5 using miScript Target Protectors

    Sources for CASP5 Gene

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