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Aliases for CASP5 Gene

Aliases for CASP5 Gene

  • Caspase 5 2 3 5
  • Caspase 5, Apoptosis-Related Cysteine Peptidase 2 3
  • Caspase 5, Apoptosis-Related Cysteine Protease 2 3
  • Protease ICH-3 3 4
  • ICE(Rel)-III 3 4
  • Protease TY 3 4
  • CASP-5 3 4
  • EC 3.4.22.58 4
  • TY Protease 3
  • ICE(Rel)III 3
  • ICEREL-III 3
  • EC 3.4.22 63
  • ICH-3 3
  • ICH3 4

External Ids for CASP5 Gene

Previous GeneCards Identifiers for CASP5 Gene

  • GC11M107058
  • GC11M106221
  • GC11M104899
  • GC11M104402
  • GC11M104370
  • GC11M104864
  • GC11M100795

Summaries for CASP5 Gene

Entrez Gene Summary for CASP5 Gene

  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for CASP5 Gene

CASP5 (Caspase 5) is a Protein Coding gene. Diseases associated with CASP5 include cowpox. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and p53 Signaling. GO annotations related to this gene include cysteine-type endopeptidase activity and scaffold protein binding. An important paralog of this gene is CASP1.

UniProtKB/Swiss-Prot for CASP5 Gene

  • Mediator of programmed cell death (apoptosis).

Tocris Summary for CASP5 Gene

  • Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP5 Gene

Genomics for CASP5 Gene

Regulatory Elements for CASP5 Gene

Promoters for CASP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CASP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CASP5 Gene

Chromosome:
11
Start:
104,992,633 bp from pter
End:
105,023,221 bp from pter
Size:
30,589 bases
Orientation:
Minus strand

Genomic View for CASP5 Gene

Genes around CASP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP5 Gene

Proteins for CASP5 Gene

  • Protein details for CASP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51878-CASP5_HUMAN
    Recommended name:
    Caspase-5
    Protein Accession:
    P51878
    Secondary Accessions:
    • B4DKP5
    • Q0QVY7
    • Q0QVY8
    • Q0QVZ0
    • Q0QVZ1
    • Q0QVZ2
    • Q14DD6
    • Q1HBJ3
    • Q6DJV7

    Protein attributes for CASP5 Gene

    Size:
    434 amino acids
    Molecular mass:
    49736 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunits. Interacts with MEFV.
    SequenceCaution:
    • Sequence=AAA75172.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH74994.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI13407.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=ABF47103.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG59257.1; Type=Frameshift; Positions=10; Evidence={ECO:0000305}; Sequence=CAA64450.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CASP5 Gene

neXtProt entry for CASP5 Gene

Proteomics data for CASP5 Gene at MOPED

Selected DME Specific Peptides for CASP5 Gene

Post-translational modifications for CASP5 Gene

  • The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CASP5 (CASP5)

Assay Products

  • Enzo Life Sciences assays for CASP5
  • Cloud-Clone Corp Assay Kits for CASP5

Domains & Families for CASP5 Gene

Gene Families for CASP5 Gene

Suggested Antigen Peptide Sequences for CASP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51878

UniProtKB/Swiss-Prot:

CASP5_HUMAN :
  • Contains 1 CARD domain.
  • Belongs to the peptidase C14A family.
Domain:
  • Contains 1 CARD domain.
Family:
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP5: view

Function for CASP5 Gene

Molecular function for CASP5 Gene

GENATLAS Biochemistry:
caspase 5,cysteine containing aspartate-specific protease,CASP1 subfamily,potentially involved in procytokine activation,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,promoting apoptosis,target gene in the microsatellite mutator pathway for cancer
UniProtKB/Swiss-Prot CatalyticActivity:
Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp- - but also cleaves at Asp-Glu-Val-Asp- -.
UniProtKB/Swiss-Prot Function:
Mediator of programmed cell death (apoptosis).
UniProtKB/Swiss-Prot Induction:
Up-regulated by bacterial lipopolysaccharides (LPS).

Enzyme Numbers (IUBMB) for CASP5 Gene

genes like me logo Genes that share phenotypes with CASP5: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CASP5 Gene

Localization for CASP5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CASP5 Gene COMPARTMENTS Subcellular localization image for CASP5 gene
Compartment Confidence
cytosol 5
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CASP5 Gene

Pathways & Interactions for CASP5 Gene

genes like me logo Genes that share pathways with CASP5: view

Pathways by source for CASP5 Gene

3 Sino Biological pathways for CASP5 Gene
1 GeneTex pathway for CASP5 Gene
1 BioSystems pathway for CASP5 Gene
1 KEGG pathway for CASP5 Gene
1 R&D Systems pathway for CASP5 Gene

Gene Ontology (GO) - Biological Process for CASP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0035234 ectopic germ cell programmed cell death IEA --
GO:0050727 regulation of inflammatory response IBA --
GO:0070269 pyroptosis IEA --
GO:0071260 cellular response to mechanical stimulus IEP 19593445
genes like me logo Genes that share ontologies with CASP5: view

No data available for SIGNOR curated interactions for CASP5 Gene

Drugs & Compounds for CASP5 Gene

(4) Drugs for CASP5 Gene - From: IUPHAR, DGIdb, Novoseek, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Z-WEHD-FMK Pharma Inhibition, Inhibitor 0
z-VAD-fmk Pharma Cell-permeable, irreversible pan-caspase inhibitor 0
MDL 28170 Pharma Calpain and cathepsin B inhibitor, selective, Potent, selective calpain and cathepsin B inhibitor 0

(5) Additional Compounds for CASP5 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Calpeptin
117591-20-5
MG 132
133407-82-6
N-Acetyl-L-leucyl-L-leucyl-L-methional
136632-32-1
PD 150606
179528-45-1

(5) Tocris Compounds for CASP5 Gene

Compound Action Cas Number
Calpeptin Calpain and cathepsin L inhibitor 117591-20-5
MDL 28170 Potent, selective calpain and cathepsin B inhibitor 88191-84-8
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation 133407-82-6
N-Acetyl-L-leucyl-L-leucyl-L-methional Cathepsin inhibitor 136632-32-1
PD 150606 Cell permeable calpain inhibitor 179528-45-1

(1) ApexBio Compounds for CASP5 Gene

Compound Action Cas Number
Z-VAD-FMK Cell-permeable, irreversible pan-caspase inhibitor 187389-52-2
genes like me logo Genes that share compounds with CASP5: view

Drug Products

Transcripts for CASP5 Gene

mRNA/cDNA for CASP5 Gene

Unigene Clusters for CASP5 Gene

Caspase 5, apoptosis-related cysteine peptidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CASP5 Gene

No ASD Table

Relevant External Links for CASP5 Gene

GeneLoc Exon Structure for
CASP5
ECgene alternative splicing isoforms for
CASP5

Expression for CASP5 Gene

mRNA expression in normal human tissues for CASP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CASP5 Gene

This gene is overexpressed in Whole Blood (x23.7), Colon - Transverse (x11.3), and Small Intestine - Terminal Ileum (x8.9).

Protein differential expression in normal tissues from HIPED for CASP5 Gene

This gene is overexpressed in Plasma (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CASP5 Gene



SOURCE GeneReport for Unigene cluster for CASP5 Gene Hs.213327

mRNA Expression by UniProt/SwissProt for CASP5 Gene

P51878-CASP5_HUMAN
Tissue specificity: Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle.
genes like me logo Genes that share expression patterns with CASP5: view

Protein tissue co-expression partners for CASP5 Gene

Primer Products

In Situ Assay Products

Orthologs for CASP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CASP5 35
  • 99.08 (n)
  • 97.8 (a)
CASP5 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CASP13 36
  • 68 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CASP4 36
  • 50 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 17 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Casp4 36
  • 54 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii caspb 36
  • 26 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Dredd 36
  • 12 (a)
ManyToMany
Nc 36
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea csp-1 36
  • 15 (a)
ManyToMany
Species with no ortholog for CASP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CASP5 Gene

ENSEMBL:
Gene Tree for CASP5 (if available)
TreeFam:
Gene Tree for CASP5 (if available)

Paralogs for CASP5 Gene

Paralogs for CASP5 Gene

(6) SIMAP similar genes for CASP5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CASP5: view

Variants for CASP5 Gene

Sequence variations from dbSNP and Humsavar for CASP5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs3181320 - 105,008,901(-) AACTT(C/G)GTGAT intron-variant, reference, missense
rs3181179 - 105,003,314(-) TCCTC(A/G)TGAAG intron-variant, reference, missense
rs3181326 - 105,002,096(+) ACATC(C/G/T)TGGGG nc-transcript-variant, reference, missense
rs45483102 - 105,008,931(-) TTCAA(A/T)GGTAT intron-variant, reference, missense
rs1792778 - 105,008,911(-) TGGAT(G/T)GGATA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CASP5 Gene

Variant ID Type Subtype PubMed ID
esv2750978 CNV Gain 17911159
nsv898355 CNV Gain 21882294
nsv468862 CNV Gain 19166990

Variation tolerance for CASP5 Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CASP5 Gene

HapMap Linkage Disequilibrium report
CASP5
Human Gene Mutation Database (HGMD)
CASP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASP5 Gene

Disorders for CASP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CASP5 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
cowpox
  • yaba
- elite association - COSMIC cancer census association via MalaCards
Search CASP5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CASP5

Genetic Association Database (GAD)
CASP5
Human Genome Epidemiology (HuGE) Navigator
CASP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CASP5
genes like me logo Genes that share disorders with CASP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CASP5 Gene

Publications for CASP5 Gene

  1. Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases. (PMID: 7797592) Munday N.A. … Nicholson D.W. (J. Biol. Chem. 1995) 2 3 4 23 67
  2. Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival. (PMID: 19270026) Quaye L. … Gayther S.A. (Hum. Mol. Genet. 2009) 3 23
  3. Mutational analysis of caspase 1, 4, and 5 genes in common human cancers. (PMID: 18430458) Soung Y.H. … Lee S.H. (Hum. Pathol. 2008) 3 23
  4. TGF-betaRII, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 alterations are not associated with microsatellite instability or p53 mutations in invasive urothelial carcinoma of the urinary bladder. (PMID: 17676485) Saetta A.A. … Patsouris E. (Pathology 2007) 3 23
  5. Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PMID: 16886895) Hwang Y. … Chen D.S. (Pharmacogenomics 2006) 3 23

Products for CASP5 Gene

Sources for CASP5 Gene

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