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Aliases for CASP4 Gene

Aliases for CASP4 Gene

  • Caspase 4, Apoptosis-Related Cysteine Peptidase 2 3
  • Caspase 4, Apoptosis-Related Cysteine Protease 2 3
  • Protease ICH-2 3 4
  • Protease TX 3 4
  • ICE(Rel)-II 3 4
  • CASP-4 3 4
  • Apoptotic Cysteine Protease Mih1/TX 3
  • EC 4
  • ICE(Rel)II 3
  • EC 3.4.22 63
  • Mih1/TX 3
  • ICH-2 3
  • ICH2 4
  • TX 3

External Ids for CASP4 Gene

Previous GeneCards Identifiers for CASP4 Gene

  • GC11M107006
  • GC11M106170
  • GC11M104806
  • GC11M104351
  • GC11M104318
  • GC11M100744

Summaries for CASP4 Gene

Entrez Gene Summary for CASP4 Gene

  • This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CASP4 Gene

CASP4 (Caspase 4, Apoptosis-Related Cysteine Peptidase) is a Protein Coding gene. Diseases associated with CASP4 include hepatitis c virus. Among its related pathways are Immune System and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type endopeptidase activity involved in execution phase of apoptosis. An important paralog of this gene is CASP1.

UniProtKB/Swiss-Prot for CASP4 Gene

  • Involved in the activation cascade of caspases responsible for apoptosis execution. Involved in ER-stress induced apoptosis. Cleaves caspase-1.

Tocris Summary for CASP4 Gene

  • Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP4 Gene

Genomics for CASP4 Gene

Regulatory Elements for CASP4 Gene

Transcription factor binding sites by QIAGEN in the CASP4 gene promoter:

Genomic Location for CASP4 Gene

104,942,866 bp from pter
104,969,436 bp from pter
26,571 bases
Minus strand

Genomic View for CASP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CASP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP4 Gene

Proteins for CASP4 Gene

  • Protein details for CASP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A2NHL8
    • A2NHM0

    Protein attributes for CASP4 Gene

    377 amino acids
    Molecular mass:
    43262 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit (By similarity). Interacts with NleF from pathogenic E.coli. Interacts with TMEM214, the interaction is required for ER membrane localization.

    Alternative splice isoforms for CASP4 Gene


neXtProt entry for CASP4 Gene

Proteomics data for CASP4 Gene at MOPED

Post-translational modifications for CASP4 Gene

  • The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CASP4 Gene

Domains & Families for CASP4 Gene

Gene Families for CASP4 Gene

Suggested Antigen Peptide Sequences for CASP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CARD domain.
  • Belongs to the peptidase C14A family.
  • Contains 1 CARD domain.
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP4: view

Function for CASP4 Gene

Molecular function for CASP4 Gene

GENATLAS Biochemistry:
caspase 4,cysteine containing aspartate-specific protease,CASP1 subfamily,potentially involved in procytokine activation,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,promoting apoptosis,homolog to mammalian interleukin 1 beta convertase (IL1BC)
UniProtKB/Swiss-Prot CatalyticActivity:
Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp- - but also cleaves at Asp-Glu-Val-Asp- -.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the effector protein NleF that is produced by pathogenic E.coli; this inhibits apoptosis.
UniProtKB/Swiss-Prot Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Involved in ER-stress induced apoptosis. Cleaves caspase-1.

Enzyme Numbers (IUBMB) for CASP4 Gene

Gene Ontology (GO) - Molecular Function for CASP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity --
GO:0008234 cysteine-type peptidase activity --
GO:0097200 NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA --
genes like me logo Genes that share ontologies with CASP4: view
genes like me logo Genes that share phenotypes with CASP4: view

Animal Models for CASP4 Gene

MGI Knock Outs for CASP4:

miRNA for CASP4 Gene

miRTarBase miRNAs that target CASP4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CASP4

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CASP4 Gene

Localization for CASP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CASP4 Gene

Endoplasmic reticulum membrane. Mitochondrion.

Subcellular locations from

Jensen Localization Image for CASP4 Gene COMPARTMENTS Subcellular localization image for CASP4 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
cytosol 3
plasma membrane 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CASP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IDA 15123740
GO:0005783 endoplasmic reticulum IDA 15123740
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0072557 IPAF inflammasome complex IBA --
genes like me logo Genes that share ontologies with CASP4: view

Pathways & Interactions for CASP4 Gene

genes like me logo Genes that share pathways with CASP4: view

Pathways by source for CASP4 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for CASP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006915 apoptotic process TAS 7743998
GO:0042981 regulation of apoptotic process IEA --
GO:0050727 regulation of inflammatory response IBA --
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP 15123740
genes like me logo Genes that share ontologies with CASP4: view

No data available for SIGNOR curated interactions for CASP4 Gene

Drugs & Compounds for CASP4 Gene

(11) Drugs for CASP4 Gene - From: Tocris, ApexBio, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Bortezomib Approved, Experimental, Investigational Pharma Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 758
Indomethacin Approved, Investigational Pharma Inhibition, Inhibitor Cox inhibitor 97
Apoptosis Activator 2 Pharma Indoledione caspase activator, cell-permeable 0
Tasisulam Pharma 0

(4) Additional Compounds for CASP4 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
genes like me logo Genes that share compounds with CASP4: view

Transcripts for CASP4 Gene

Unigene Clusters for CASP4 Gene

Caspase 4, apoptosis-related cysteine peptidase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CASP4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CASP4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: -
SP3: - - -

Relevant External Links for CASP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CASP4 Gene

mRNA expression in normal human tissues for CASP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CASP4 Gene

This gene is overexpressed in Whole Blood (x12.6).

Protein differential expression in normal tissues from HIPED for CASP4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.9), Cervix (8.6), and Monocytes (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CASP4 Gene

SOURCE GeneReport for Unigene cluster for CASP4 Gene Hs.138378

mRNA Expression by UniProt/SwissProt for CASP4 Gene

Tissue specificity: Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain
genes like me logo Genes that share expression patterns with CASP4: view

Protein tissue co-expression partners for CASP4 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CASP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CASP4 35
  • 82.23 (n)
  • 75.6 (a)
CASP13 36
  • 76 (a)
(Mus musculus)
Mammalia Casp4 35
  • 69.26 (n)
  • 60.32 (a)
Casp4 16
Casp4 36
  • 60 (a)
(Pan troglodytes)
Mammalia CASP4 35
  • 99.29 (n)
  • 99.2 (a)
CASP4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Casp4 35
  • 68.54 (n)
  • 59.79 (a)
(Canis familiaris)
Mammalia CASP4 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
(Gallus gallus)
Aves -- 36
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
(Danio rerio)
Actinopterygii caspbl 36
  • 28 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dredd 36
  • 12 (a)
Nc 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea csp-2 36
  • 9 (a)
Species with no ortholog for CASP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CASP4 Gene

Gene Tree for CASP4 (if available)
Gene Tree for CASP4 (if available)

Paralogs for CASP4 Gene

(6) SIMAP similar genes for CASP4 Gene using alignment to 3 proteins: Pseudogenes for CASP4 Gene

genes like me logo Genes that share paralogs with CASP4: view

Variants for CASP4 Gene

Sequence variations from dbSNP and Humsavar for CASP4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs9507 -- 104,948,600(-) AACCT(A/G)GAGGA reference, synonymous-codon
rs473086 -- 104,963,012(-) aggtg(C/T)ttcaa intron-variant
rs474866 -- 104,962,849(-) GAAAT(C/T)GTTCC intron-variant
rs506761 -- 104,948,195(-) TGATT(A/C)TACAA intron-variant
rs509982 -- 104,945,041(-) AAAGC(A/G)TACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CASP4 Gene

Variant ID Type Subtype PubMed ID
esv2750978 CNV Gain 17911159
nsv832255 CNV Loss 17160897
nsv898355 CNV Gain 21882294
nsv468862 CNV Gain 19166990
nsv898356 CNV Loss 21882294
nsv469 CNV Insertion 18451855

Variation tolerance for CASP4 Gene

Residual Variation Intolerance Score: 72.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CASP4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASP4 Gene

Disorders for CASP4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CASP4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitic c virus
- elite association
Search CASP4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CASP4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CASP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CASP4 Gene

Publications for CASP4 Gene

  1. Methylanthraquinone from Hedyotis diffusa WILLD induces Ca(2+)-mediated apoptosis in human breast cancer cells. (PMID: 19686834) Liu Z. … Li J. (Toxicol In Vitro 2010) 23 67
  2. Evidence that endoplasmic reticulum (ER) stress and caspase-4 activation occur in human neutrophils. (PMID: 19878647) Binet F. … Girard D. (Biochem. Biophys. Res. Commun. 2010) 23 67
  3. Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes. (PMID: 19894226) Das A. … Ray S.K. (Cancer 2010) 23 67
  4. Arsenic trioxide induces endoplasmic reticulum stress-related events in neutrophils. (PMID: 20138156) Binet F. … Girard D. (Int. Immunopharmacol. 2010) 23 67
  5. Oxidative and endoplasmic reticulum stress signaling are involved in dehydrocostuslactone-mediated apoptosis in human non-small cell lung cancer cells. (PMID: 19700217) Hung J.Y. … Huang M.S. (Lung Cancer 2010) 23 67

Products for CASP4 Gene

Sources for CASP4 Gene

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