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Aliases for CASP4 Gene

Aliases for CASP4 Gene

  • Caspase 4, Apoptosis-Related Cysteine Peptidase 2 3
  • Caspase 4, Apoptosis-Related Cysteine Protease 2 3
  • Protease ICH-2 3 4
  • Protease TX 3 4
  • ICE(Rel)-II 3 4
  • CASP-4 3 4
  • Apoptotic Cysteine Protease Mih1/TX 3
  • EC 3.4.22.57 4
  • ICE(Rel)II 3
  • ICEREL-II 3
  • Caspase-4 3
  • EC 3.4.22 63
  • Mih1/TX 3
  • ICH-2 3
  • ICH2 4
  • TX 3

External Ids for CASP4 Gene

Previous GeneCards Identifiers for CASP4 Gene

  • GC11M107006
  • GC11M106170
  • GC11M104806
  • GC11M104351
  • GC11M104318
  • GC11M100744

Summaries for CASP4 Gene

Entrez Gene Summary for CASP4 Gene

  • This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CASP4 Gene

CASP4 (Caspase 4, Apoptosis-Related Cysteine Peptidase) is a Protein Coding gene. Diseases associated with CASP4 include myocardial infarction. Among its related pathways are PAK Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include cysteine-type endopeptidase activity. An important paralog of this gene is CASP1.

UniProtKB/Swiss-Prot for CASP4 Gene

  • Involved in the activation cascade of caspases responsible for apoptosis execution. Involved in ER-stress induced apoptosis. Cleaves caspase-1.

Tocris Summary for CASP4 Gene

  • Caspases (short for �cysteinyl aspartate proteases�) are involved in the signal transduction pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory disease.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP4 Gene

Genomics for CASP4 Gene

Regulatory Elements for CASP4 Gene

Transcription factor binding sites by QIAGEN in the CASP4 gene promoter:

Genomic Location for CASP4 Gene

Start:
104,942,866 bp from pter
End:
104,969,436 bp from pter
Size:
26,571 bases
Orientation:
Minus strand

Genomic View for CASP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CASP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP4 Gene

Proteins for CASP4 Gene

  • Protein details for CASP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49662-CASP4_HUMAN
    Recommended name:
    Caspase-4
    Protein Accession:
    P49662
    Secondary Accessions:
    • A2NHL8
    • A2NHM0

    Protein attributes for CASP4 Gene

    Size:
    377 amino acids
    Molecular mass:
    43262 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit (By similarity). Interacts with NleF from pathogenic E.coli. Interacts with TMEM214, the interaction is required for ER membrane localization.

    Alternative splice isoforms for CASP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CASP4 Gene

Proteomics data for CASP4 Gene at MOPED

Post-translational modifications for CASP4 Gene

  • The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CASP4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CASP4 Gene

Gene Families for CASP4 Gene

HGNC:
IUPHAR :

Suggested Antigen Peptide Sequences for CASP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49662

UniProtKB/Swiss-Prot:

CASP4_HUMAN :
  • P49662
Domain:
  • Contains 1 CARD domain.
Family:
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP4: view

Function for CASP4 Gene

Molecular function for CASP4 Gene

GENATLAS Biochemistry: caspase 4,cysteine containing aspartate-specific protease,CASP1 subfamily,potentially involved in procytokine activation,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,promoting apoptosis,homolog to mammalian interleukin 1 beta convertase (IL1BC)
UniProtKB/Swiss-Prot CatalyticActivity: Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp- - but also cleaves at Asp-Glu-Val-Asp- -.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by the effector protein NleF that is produced by pathogenic E.coli; this inhibits apoptosis.
UniProtKB/Swiss-Prot Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Involved in ER-stress induced apoptosis. Cleaves caspase-1.

Enzyme Numbers (IUBMB) for CASP4 Gene

Gene Ontology (GO) - Molecular Function for CASP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity --
GO:0008234 cysteine-type peptidase activity --
GO:0097200 NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA --
genes like me logo Genes that share ontologies with CASP4: view
genes like me logo Genes that share phenotypes with CASP4: view

Animal Models for CASP4 Gene

MGI Knock Outs for CASP4:

Animal Model Products

miRNA for CASP4 Gene

miRTarBase miRNAs that target CASP4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CASP4

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for CASP4 Gene

Localization for CASP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CASP4 Gene

Endoplasmic reticulum membrane. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CASP4 Gene COMPARTMENTS Subcellular localization image for CASP4 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 3
mitochondrion 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CASP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IDA 15123740
GO:0005783 endoplasmic reticulum IDA 15123740
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with CASP4: view

Pathways for CASP4 Gene

genes like me logo Genes that share pathways with CASP4: view

Pathways by source for CASP4 Gene

3 Sino Biological pathways for CASP4 Gene
1 Cell Signaling Technology pathway for CASP4 Gene
2 BioSystems pathways for CASP4 Gene
1 GeneGo (Thomson Reuters) pathway for CASP4 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for CASP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006915 apoptotic process TAS 7743998
GO:0042981 regulation of apoptotic process IEA --
GO:0050727 regulation of inflammatory response IBA --
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP 15123740
genes like me logo Genes that share ontologies with CASP4: view

Compounds for CASP4 Gene

(5) Tocris Compounds for CASP4 Gene

Compound Action Cas Number
Ac-LEHD-AFC Fluorogenic caspase substrate [210345-03-2]
Cisplatin Potent pro-apoptotic anticancer agent; activates caspase-3 [15663-27-1]
Z-DQMD-FMK Caspase-3 inhibitor
Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor [187389-52-2]
Z-VDVAD-FMK Irreversible caspase-2 inhibitor

(12) ApexBio Compounds for CASP4 Gene

Compound Action Cas Number
Apoptosis Inhibitor Cell-permeable caspase-3 inhibitor [54135-60-3]
Caspase-3/7 Inhibitor I Cell-permeable and irreversible inhibitor of caspase-3 and -7 [220509-74-0]
Cisplatin Chemotherapy agent, induces apoptosis [15663-27-1]
PAC-1 Procaspase-activating compound, activates procaspase-3 and converts it to caspase-3 [315183-21-2]
Q-VD-Oph Cell-permeable, irreversible pan-caspase inhibitor [1135695-98-5]
VX-765 Novel Caspase-1 inhibitor [273404-37-8]
Z-DEVD-FMK Cell-permeable, and irreversible caspase-3 inhibitor [210344-95-9]
Z-DQMD-FMK Cell-permeable caspase-3 inhibitor
Z-FA-FMK An inhibitor of cysteine proteases, such as cathepsin B.
Z-VAD-FMK Cell-permeable, irreversible pan-caspase inhibitor [187389-52-2]
Z-VDVAD-FMK Cell-permeable and irreversible caspase-2 inhibitor
Z-VEID-FMK Cell-permeable and irreversible caspase-6 inhibitor

(8) Novoseek inferred chemical compound relationships for CASP4 Gene

Compound -log(P) Hits PubMed IDs
tunicamycin 73.4 3
bortezomib 47.7 4
thapsigargin 41.8 3
cysteine 40.9 2
tetrapeptide 31.1 1
genes like me logo Genes that share compounds with CASP4: view

Transcripts for CASP4 Gene

Unigene Clusters for CASP4 Gene

Caspase 4, apoptosis-related cysteine peptidase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CASP4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CASP4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: -
SP2:
SP3: - - -
SP4:

Relevant External Links for CASP4 Gene

GeneLoc Exon Structure for
CASP4
ECgene alternative splicing isoforms for
CASP4

Expression for CASP4 Gene

mRNA expression in normal human tissues for CASP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CASP4 Gene

This gene is overexpressed in Whole Blood (12.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CASP4 Gene

SOURCE GeneReport for Unigene cluster for CASP4 Gene Hs.138378

mRNA Expression by UniProt/SwissProt for CASP4 Gene

P49662-CASP4_HUMAN
Tissue specificity: Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain
genes like me logo Genes that share expressions with CASP4: view

In Situ Assay Products

Orthologs for CASP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CASP4 35
  • 99.29 (n)
  • 99.2 (a)
CASP4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CASP13 36
  • 76 (a)
OneToMany
CASP4 35
  • 82.23 (n)
  • 75.6 (a)
dog
(Canis familiaris)
Mammalia CASP4 36
  • 51 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Casp4 35
  • 69.26 (n)
  • 60.32 (a)
Casp4 16
Casp4 36
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Casp4 35
  • 68.54 (n)
  • 59.79 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii caspbl 36
  • 28 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Dredd 36
  • 12 (a)
ManyToMany
Nc 36
  • 17 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea csp-2 36
  • 9 (a)
ManyToMany
Species with no ortholog for CASP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CASP4 Gene

ENSEMBL:
Gene Tree for CASP4 (if available)
TreeFam:
Gene Tree for CASP4 (if available)

Paralogs for CASP4 Gene

Selected SIMAP similar genes for CASP4 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CASP4 Gene

genes like me logo Genes that share paralogs with CASP4: view

Variants for CASP4 Gene

Sequence variations from dbSNP and Humsavar for CASP4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs9507 -- 104,948,600(-) AACCT(A/G)GAGGA reference, synonymous-codon
rs473086 -- 104,963,012(-) aggtg(C/T)ttcaa intron-variant
rs474866 -- 104,962,849(-) GAAAT(C/T)GTTCC intron-variant
rs506761 -- 104,948,195(-) TGATT(A/C)TACAA intron-variant
rs509982 -- 104,945,041(-) AAAGC(A/G)TACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CASP4 Gene

Variant ID Type Subtype PubMed ID
esv2750978 CNV Gain 17911159
nsv832255 CNV Loss 17160897
nsv898355 CNV Gain 21882294
nsv468862 CNV Gain 19166990
nsv898356 CNV Loss 21882294
nsv469 CNV Insertion 18451855

Relevant External Links for CASP4 Gene

HapMap Linkage Disequilibrium report
CASP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASP4 Gene

Disorders for CASP4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CASP4 Gene including...

Search for CASP4 Gene in MalaCards »

(11) Novoseek inferred disease relationships for CASP4 Gene

Disease -log(P) Hits PubMed IDs
cowpox 49.2 1
cancer 25.2 2
alzheimers disease 17.7 3
melanoma 16.8 4
tumors 15.5 5

Relevant External Links for CASP4

Genetic Association Database (GAD)
CASP4
Human Genome Epidemiology (HuGE) Navigator
CASP4
genes like me logo Genes that share disorders with CASP4: view

No data available for UniProtKB/Swiss-Prot for CASP4 Gene

Publications for CASP4 Gene

  1. Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases. (PMID: 7797592) Munday N.A. … Nicholson D.W. (J. Biol. Chem. 1995) 3 4 23
  2. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. (PMID: 15123740) Hitomi J. … Tohyama M. (J. Cell Biol. 2004) 3 4 23
  3. Mutational analysis of CASP1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 14 genes in gastrointestinal stromal tumors. (PMID: 19269008) Kim Y.R. … Lee S.H. (Hum. Pathol. 2009) 3 23 48
  4. Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases. (PMID: 7797510) Kamens J. … Ghayur T. (J. Biol. Chem. 1995) 2 3 4
  5. Distinct mechanism of cell death is responsible for tunicamycin-induced ER stress in SK-N-SH and SH-SY5Y cells. (PMID: 18029041) Oda T. … Ito Y. (Neurosci. Res. 2008) 3 23

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