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Aliases for CASP4 Gene

Aliases for CASP4 Gene

  • Caspase 4 2 3 5
  • Caspase 4, Apoptosis-Related Cysteine Peptidase 2 3
  • Caspase 4, Apoptosis-Related Cysteine Protease 2 3
  • ICE And Ced-3 Homolog 2 3 4
  • Protease TX 3 4
  • ICE(Rel)-II 3 4
  • CASP-4 3 4
  • ICH-2 3 4
  • Mih1 3 4
  • Apoptotic Cysteine Protease Mih1/TX 3
  • Protease ICH-2 3
  • EC 3.4.22.57 4
  • ICE(Rel)II 3
  • ICEREL-II 3
  • EC 3.4.22 63
  • Mih1/TX 3
  • ICH2 4
  • TX 3

External Ids for CASP4 Gene

Previous GeneCards Identifiers for CASP4 Gene

  • GC11M107006
  • GC11M106170
  • GC11M104806
  • GC11M104351
  • GC11M104318
  • GC11M100744

Summaries for CASP4 Gene

Entrez Gene Summary for CASP4 Gene

  • This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CASP4 Gene

CASP4 (Caspase 4) is a Protein Coding gene. Among its related pathways are p53 Signaling and Immune System. GO annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type endopeptidase activity involved in execution phase of apoptosis. An important paralog of this gene is CASP1.

UniProtKB/Swiss-Prot for CASP4 Gene

  • Inflammatory caspase (PubMed:7797510, PubMed:23516580, PubMed:25119034). Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS (PubMed:22246630, PubMed:26174085, PubMed:26173988, PubMed:26508369, PubMed:25964352). Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators (PubMed:24879791, PubMed:25964352). Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection (PubMed:25121752). In later stages of the infection, LPS from cytosolic Salmonella triggers CASP4 activation, which ultimately results in pyroptosis of infected cells and their extrusion into the gut lumen, as well as in IL18 secretion. Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation. Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity (PubMed:26508369). Involved in cell death induced by endoplasmic reticulum stress and by treatment with cytotoxic APP peptides found Alzheimers patient brains (PubMed:15123740, PubMed:22246630, PubMed:23661706). Activated by direct binding to LPS without the need of an upstream sensor (PubMed:25119034). Does not directly process IL1B (PubMed:7743998, PubMed:7797592, PubMed:7797510).

Tocris Summary for CASP4 Gene

  • Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP4 Gene

Genomics for CASP4 Gene

Regulatory Elements for CASP4 Gene

Enhancers for CASP4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CASP4 on UCSC Golden Path with GeneCards custom track

Promoters for CASP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CASP4 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CASP4 gene promoter:

Genomic Location for CASP4 Gene

Chromosome:
11
Start:
104,942,866 bp from pter
End:
104,969,436 bp from pter
Size:
26,571 bases
Orientation:
Minus strand

Genomic View for CASP4 Gene

Genes around CASP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP4 Gene

Proteins for CASP4 Gene

  • Protein details for CASP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49662-CASP4_HUMAN
    Recommended name:
    Caspase-4
    Protein Accession:
    P49662
    Secondary Accessions:
    • A2NHL8
    • A2NHL9
    • A2NHM0
    • B3KPZ9
    • B4DJH5
    • B4E2D2
    • O95601
    • Q7KYX7
    • Q9UG96

    Protein attributes for CASP4 Gene

    Size:
    377 amino acids
    Molecular mass:
    43262 Da
    Quaternary structure:
    • Upon direct LPS-binding, forms large homooligomers, resulting in its activation. These oligomers are often referred to as non-canonical inflammasomes (PubMed:25119034). Active as a heterotetramer consisting of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit (By similarity). In its precursor form, interacts with TMEM214; this interaction is required for association with the endoplasmic reticulum membrane (PubMed:23661706). Interacts with CASP1 (PubMed:22246630). Interacts with NOD2 (PubMed:18511561).
    • (Microbial infection) Interacts with NleF protein from pathogenic E.coli; this interaction leads to enzyme inhibition.
    SequenceCaution:
    • Sequence=AAC99854.1; Type=Erroneous translation; Note=Erroneous CDS prediction.; Evidence={ECO:0000305}; Sequence=EAW67050.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CASP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CASP4 Gene

Proteomics data for CASP4 Gene at MOPED

Post-translational modifications for CASP4 Gene

  • In response to activation signals, including endoplasmic reticulum stress or treatment with amyloid beta A4 protein fragments (such as beta-amyloid protein 40), undergoes autoproteolytic cleavage.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CASP4 Gene

Domains & Families for CASP4 Gene

Gene Families for CASP4 Gene

Suggested Antigen Peptide Sequences for CASP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49662

UniProtKB/Swiss-Prot:

CASP4_HUMAN :
  • The CARD domain mediates LPS recognition and homooligomerization.
  • Belongs to the peptidase C14A family.
Domain:
  • The CARD domain mediates LPS recognition and homooligomerization.
  • Contains 1 CARD domain.
Family:
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP4: view

Function for CASP4 Gene

Molecular function for CASP4 Gene

GENATLAS Biochemistry:
caspase 4,cysteine containing aspartate-specific protease,CASP1 subfamily,potentially involved in procytokine activation,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,promoting apoptosis,homolog to mammalian interleukin 1 beta convertase (IL1BC)
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=681 uM for synthetic peptide acetyl-YVAD-p-nitroanilide {ECO:0000269 PubMed:7797510}; Note=Values obtained using the partial C-terminal enzyme sequence of 105-377. {ECO:0000269 PubMed:7797510};
UniProtKB/Swiss-Prot CatalyticActivity:
Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp- - but also cleaves at Asp-Glu-Val-Asp- -.
UniProtKB/Swiss-Prot EnzymeRegulation:
(Microbial infection) Inhibited by the effector protein NleF that is produced by pathogenic E.coli; this inhibits apoptosis (PubMed:23516580). Activated by homooligomerization induced by direct binding to cytosolic LPS, in a TLR4-independent manner (PubMed:25119034).
UniProtKB/Swiss-Prot Function:
Inflammatory caspase (PubMed:7797510, PubMed:23516580, PubMed:25119034). Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS (PubMed:22246630, PubMed:26174085, PubMed:26173988, PubMed:26508369, PubMed:25964352). Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators (PubMed:24879791, PubMed:25964352). Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection (PubMed:25121752). In later stages of the infection, LPS from cytosolic Salmonella triggers CASP4 activation, which ultimately results in pyroptosis of infected cells and their extrusion into the gut lumen, as well as in IL18 secretion. Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation. Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity (PubMed:26508369). Involved in cell death induced by endoplasmic reticulum stress and by treatment with cytotoxic APP peptides found Alzheimers patient brains (PubMed:15123740, PubMed:22246630, PubMed:23661706). Activated by direct binding to LPS without the need of an upstream sensor (PubMed:25119034). Does not directly process IL1B (PubMed:7743998, PubMed:7797592, PubMed:7797510).
UniProtKB/Swiss-Prot Induction:
In peripheral blood mononuclear cells and purified monocytes, up-regulated by bacterial lipopolysaccharides (LPS) and interferon-beta/IFNB1 at the mRNA level (PubMed:16893518, PubMed:24879791). However, this increase is not observed at the protein level, which remains constant in monocytes and other cell types following LPS treatment (PubMed:25121752) (PubMed:26508369). In monocyte-derived macrophages, some up-regulation at the protein level is observed following treatment with LPS and IFNB1 (PubMed:25964352). In SH-EP1 neuroblastoma cell line, up-regulated by NF-kappa-B RELA/p65 at both mRNA and protein levels.

Enzyme Numbers (IUBMB) for CASP4 Gene

genes like me logo Genes that share phenotypes with CASP4: view

Animal Models for CASP4 Gene

MGI Knock Outs for CASP4:

Animal Model Products

miRNA for CASP4 Gene

miRTarBase miRNAs that target CASP4

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CASP4 Gene

Localization for CASP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CASP4 Gene

Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion. Inflammasome. Secreted. Note=Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214 (PubMed:15123740). Released in the extracellular milieu by keratinocytes following UVB irradiation (PubMed:22246630). {ECO:0000269 PubMed:15123740, ECO:0000269 PubMed:22246630}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CASP4 Gene COMPARTMENTS Subcellular localization image for CASP4 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
mitochondrion 5
nucleus 2
plasma membrane 2
vacuole 1

Gene Ontology (GO) - Cellular Components for CASP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0072559 NLRP3 inflammasome complex IBA --
GO:0097169 AIM2 inflammasome complex IBA --
genes like me logo Genes that share ontologies with CASP4: view

Pathways & Interactions for CASP4 Gene

genes like me logo Genes that share pathways with CASP4: view

Pathways by source for CASP4 Gene

3 Sino Biological pathways for CASP4 Gene
2 GeneTex pathways for CASP4 Gene
1 Cell Signaling Technology pathway for CASP4 Gene
2 BioSystems pathways for CASP4 Gene

Gene Ontology (GO) - Biological Process for CASP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0045087 innate immune response IEA --
GO:0050727 regulation of inflammatory response IBA --
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP 15123740
GO:0097193 intrinsic apoptotic signaling pathway IMP 15123740
genes like me logo Genes that share ontologies with CASP4: view

No data available for SIGNOR curated interactions for CASP4 Gene

Drugs & Compounds for CASP4 Gene

(8) Drugs for CASP4 Gene - From: ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum 2569
Apoptosis Activator 2 Pharma Indoledione caspase activator, cell-permeable 0
Tasisulam Pharma 0
MDL 28170 Pharma Calpain and cathepsin B inhibitor, selective, Potent, selective calpain and cathepsin B inhibitor 0

(8) Additional Compounds for CASP4 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Calpeptin
117591-20-5
MG 132
133407-82-6
N-Acetyl-L-leucyl-L-leucyl-L-methional
136632-32-1
PD 150606
179528-45-1

(5) Tocris Compounds for CASP4 Gene

Compound Action Cas Number
Calpeptin Calpain and cathepsin L inhibitor 117591-20-5
MDL 28170 Potent, selective calpain and cathepsin B inhibitor 88191-84-8
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation 133407-82-6
N-Acetyl-L-leucyl-L-leucyl-L-methional Cathepsin inhibitor 136632-32-1
PD 150606 Cell permeable calpain inhibitor 179528-45-1

(3) ApexBio Compounds for CASP4 Gene

Compound Action Cas Number
Apoptosis Activator 2 Indoledione caspase activator, cell-permeable 79183-19-0
Cisplatin Inhibits DNA synthesis,chemotherapy drug 15663-27-1
Tasisulam 519055-62-0
genes like me logo Genes that share compounds with CASP4: view

Transcripts for CASP4 Gene

Unigene Clusters for CASP4 Gene

Caspase 4, apoptosis-related cysteine peptidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CASP4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: -
SP2:
SP3: - - -
SP4:

Relevant External Links for CASP4 Gene

GeneLoc Exon Structure for
CASP4
ECgene alternative splicing isoforms for
CASP4

Expression for CASP4 Gene

mRNA expression in normal human tissues for CASP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CASP4 Gene

This gene is overexpressed in Whole Blood (x12.6).

Protein differential expression in normal tissues from HIPED for CASP4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.9), Cervix (8.6), and Monocytes (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CASP4 Gene



SOURCE GeneReport for Unigene cluster for CASP4 Gene Hs.138378

mRNA Expression by UniProt/SwissProt for CASP4 Gene

P49662-CASP4_HUMAN
Tissue specificity: Widely expressed, including in keratinocytes and colonic and small intestinal epithelial cells (at protein level). Not detected in brain.
genes like me logo Genes that share expression patterns with CASP4: view

Protein tissue co-expression partners for CASP4 Gene

- Elite partner

Primer Products

Orthologs for CASP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CASP4 35
  • 82.23 (n)
  • 75.6 (a)
CASP13 36
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Casp4 35
  • 69.26 (n)
  • 60.32 (a)
Casp4 16
Casp4 36
  • 60 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CASP4 35
  • 99.29 (n)
  • 99.2 (a)
CASP4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Casp4 35
  • 68.54 (n)
  • 59.79 (a)
dog
(Canis familiaris)
Mammalia CASP4 36
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii caspbl 36
  • 28 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Dredd 36
  • 12 (a)
ManyToMany
Nc 36
  • 17 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea csp-2 36
  • 9 (a)
ManyToMany
Species with no ortholog for CASP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CASP4 Gene

ENSEMBL:
Gene Tree for CASP4 (if available)
TreeFam:
Gene Tree for CASP4 (if available)

Paralogs for CASP4 Gene

Paralogs for CASP4 Gene

(6) SIMAP similar genes for CASP4 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CASP4 Gene

genes like me logo Genes that share paralogs with CASP4: view

Variants for CASP4 Gene

Sequence variations from dbSNP and Humsavar for CASP4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs56226603 - 104,954,870(-) ATTAC(A/G)ATGCT reference, missense, utr-variant-5-prime
rs55901059 - 104,948,606(-) TCTGA(C/G/T)AACCT reference, missense
rs181090259 - 104,951,071(+) TGTGC(A/G)GTTGT reference, missense
rs532244 -- 104,947,734(-) CACCA(C/T)CCTGT intron-variant
rs540262 -- 104,943,989(-) ATGAT(G/T)ACTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CASP4 Gene

Variant ID Type Subtype PubMed ID
esv2750978 CNV Gain 17911159
nsv832255 CNV Loss 17160897
nsv898355 CNV Gain 21882294
nsv468862 CNV Gain 19166990
nsv898356 CNV Loss 21882294
nsv469 CNV Insertion 18451855

Variation tolerance for CASP4 Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CASP4 Gene

Disorders for CASP4 Gene

Relevant External Links for CASP4

Genetic Association Database (GAD)
CASP4
Human Genome Epidemiology (HuGE) Navigator
CASP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CASP4

No disorders were found for CASP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CASP4 Gene

Publications for CASP4 Gene

  1. Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases. (PMID: 7797510) Kamens J. … Ghayur T. (J. Biol. Chem. 1995) 2 3 4 67
  2. Mutational analysis of CASP1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 14 genes in gastrointestinal stromal tumors. (PMID: 19269008) Kim Y.R. … Lee S.H. (Hum. Pathol. 2009) 3 23
  3. Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis. (PMID: 17942194) Yukioka F. … Tohyama M. (Neurochem. Int. 2008) 3 23
  4. Distinct mechanism of cell death is responsible for tunicamycin-induced ER stress in SK-N-SH and SH-SY5Y cells. (PMID: 18029041) Oda T. … Ito Y. (Neurosci. Res. 2008) 3 23
  5. Caspase-4 interacts with TNF receptor-associated factor 6 and mediates lipopolysaccharide-induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 (macrophage-inflammatory protein-1 ). (PMID: 18056395) Lakshmanan U. … Porter A.G. (J. Immunol. 2007) 3 23

Products for CASP4 Gene

Sources for CASP4 Gene

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