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CASP3 Gene

protein-coding   GIFtS: 77
GCID: GC04M185548

Caspase 3, Apoptosis-Related Cysteine Peptidase

(Previous names: caspase 3, apoptosis-related cysteine protease)
  See CASP3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Caspase 3, Apoptosis-Related Cysteine Peptidase1 2     EC 3.4.22.563 8
CPP322 3 5     CPP32B2
Caspase 3, Apoptosis-Related Cysteine Protease1 2     apopain2
Cysteine Protease CPP322 3     caspase-32
Protein Yama2 3     PARP Cleavage Protease2
CASP-32 3     procaspase32
CPP-322 3     Apopain3
SCA-12 3     EC 3.4.228
SREBP Cleavage Activity 12 3     

External Ids:    HGNC: 15041   Entrez Gene: 8362   Ensembl: ENSG000001643057   OMIM: 6006365   UniProtKB: P425743   

Export aliases for CASP3 gene to outside databases

Previous GC identifers: GC04M186576 GC04M186228 GC04M186133 GC04M186244 GC04M185924 GC04M185785 GC04M181303


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CASP3 Gene:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential
activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive
proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and
small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the
protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of
amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative
splicing of this gene results in two transcript variants that encode the same protein. (provided by RefSeq, Jul
2008)

GeneCards Summary for CASP3 Gene:
CASP3 (caspase 3, apoptosis-related cysteine peptidase) is a protein-coding gene. Diseases associated with CASP3 include nervous system cancer, and cerebral hypoxia. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and peptidase activity. An important paralog of this gene is CASP16.

UniProtKB/Swiss-Prot: CASP3_HUMAN, P42574
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of
apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves
and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine
zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the
cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage

summary for CASP3 Gene:
Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of
apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and
effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with,
upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector
caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the
executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase
Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors
such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For
example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form
part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by
inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of
many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory
disease.

Gene Wiki entry for CASP3 (Caspase 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CASP3 gene promoter:
         PPAR-alpha   AP-1   ATF-2   c-Jun   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCASP3 promoter sequence
   Search Chromatin IP Primers for CASP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CASP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q34

CASP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CASP3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M185548:  view genomic region     (about GC identifiers)

Start:
185,548,850 bp from pter      End:
185,570,663 bp from pter
Size:
21,814 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CASP3_HUMAN, P42574 (See protein sequence)
Recommended Name: Caspase-3 precursor  
Size: 277 amino acids; 31608 Da
Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa
(p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce
Selected PDB 3D structures from and Proteopedia for CASP3 (see all 69):
1CP3 (3D)        1GFW (3D)        1I3O (3D)        1NME (3D)        1NMQ (3D)        1NMS (3D)    
Secondary accessions: A8K5M2 D3DP53 Q96AN1 Q96KP2

Explore the universe of human proteins at neXtProt for CASP3: NX_P42574

Explore proteomics data for CASP3 at MOPED

Post-translational modifications: 

  • Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional
    processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active
    heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and
    vice versa1
  • S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation
    of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore
    activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by
    stimulating the denitrosylation of its active site thiol1
  • Ubiquitination2 at Lys229
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CASP3 (P42574) (see all 14)
     PGYYSWR  SVDSKSI  IIQACRG  CVLLSHG 


    See CASP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004337.2  NP_116786.1  

    ENSEMBL proteins: 
     ENSP00000377210   ENSP00000311032   ENSP00000428929   ENSP00000428372   ENSP00000377213  
     ENSP00000407142  
    Reactome Protein details: P42574

    CASP3 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CASP3 Protein
    R&D Systems Recombinant & Natural Proteins for CASP3 (Caspase-3)
    Enzo Life Sciences proteins for CASP3
    OriGene Purified Proteins for CASP3
    OriGene Protein Over-expression Lysate for CASP3
    OriGene MassSpec for CASP3
    OriGene Custom Protein Services for CASP3
    GenScript Custom Purified and Recombinant Proteins Services for CASP3
    Novus Biologicals CASP3 Proteins
    Novus Biologicals CASP3 Lysates
    Sino Biological Recombinant Protein for CASP3
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CASP3

     
    Search eBioscience for Proteins for CASP3 

    CASP3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CASP3
    R&D Systems Antibodies for CASP3 (Caspase-3)
    Cell Signaling Technology (CST) Antibodies for CASP3 
    OriGene Antibodies for CASP3
    OriGene Custom Antibody Services for CASP3
    Novus Biologicals CASP3 Antibodies
    Abcam antibodies for CASP3
    Cloud-Clone Corp. Antibodies for CASP3
    ThermoFisher Antibody for CASP3
    LSBio Antibodies in human, mouse, rat for CASP3

    CASP3 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of CASP3
    OriGene Custom Assay Services for CASP3
    R&D Systems ELISAs for CASP3 (Caspase-3)         (see all)
    GenScript CASP3-Activity-based Protease?src=genec Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for CASP3
    Enzo Life Sciences assays for CASP3
    Cloud-Clone Corp. ELISAs for CASP3
    Cloud-Clone Corp. CLIAs for CASP3
    eBioscience ELISAs for CASP3:  
                        Human Caspase-3 Instant ELISA 128 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CASP: Caspases

    IUPHAR Guide to PHARMACOLOGY protein family classification: Caspase 3
    Caspases

    5 InterPro protein domains:
     IPR001309 Pept_C14_ICE_p20
     IPR002138 Pept_C14_p10
     IPR015917 Pept_C14A_p45_core
     IPR011600 Pept_C14_caspase
     IPR016129 Pept_C14_ICE_p20_AS

    Graphical View of Domain Structure for InterPro Entry P42574

    ProtoNet protein and cluster: P42574

    2 Blocks protein domains:
    IPB001309 Caspase-1
    IPB002398 Interleukin-1B converting enzyme signature


    UniProtKB/Swiss-Prot: CASP3_HUMAN, P42574
    Similarity: Belongs to the peptidase C14A family


    Find genes that share domains with CASP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CASP3_HUMAN, P42574
    Function: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of
    apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves
    and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine
    zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the
    cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage
    Catalytic activity: Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage
    sequence of Asp-Xaa-Xaa-Asp- - with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue
    at P3, although Val or Ala are also accepted at this position
    Enzyme regulation: Inhibited by isatin sulfonamides

         Genatlas biochemistry entry for CASP3:
    caspase 3,effector,cysteine containing aspartate-specific protease CPP32,activated by CASP9,cleaving specifically
    CDKN1A,alpha-fodrin (SPTAN1), gelsolin (GSN),stored in the mitochondrial intermembrane space and released into
    cytosol after appropriate apoptotic stimuli,promoting CD95/APO1/fas mediated apoptosis,homolog to C elegans Ced-3
    and mammalian interleukin 1 beta convertase (IL1BC),including two isoforms alpha and beta

         Enzyme Numbers (IUBMB): EC 3.4.22.561 2 EC 3.4.222

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004190aspartic-type endopeptidase activity EXP--
    GO:0004197cysteine-type endopeptidase activity TAS--
    GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity IEA--
    GO:0005515protein binding IPI16501604
    GO:0008233peptidase activity IDA17167422
         
    Find genes that share ontologies with CASP3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CASP3:
     Increased cell death HMECs cel  Increased cell death in breast  Increased viability with pacli 

         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Casp3) (see all 23):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  muscle  nervous system 

    Find genes that share phenotypes with CASP3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CASP3: Casp3tm1Flv Casp3tm1Kin Casp3tm1Mak

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CASP3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CASP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CASP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CASP3

    miRNA
    Products:
        
    miRTarBase miRNAs that target CASP3:
    hsa-mir-30d-5p (MIRT006240), hsa-mir-196a-5p (MIRT048249), hsa-let-7a-5p (MIRT005292), hsa-mir-138-5p (MIRT006864), hsa-mir-221-3p (MIRT024157), hsa-mir-128-3p (MIRT021992), hsa-mir-375 (MIRT019884), hsa-mir-26b-5p (MIRT029617)

    Block miRNA regulation of human, mouse, rat CASP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CASP3 (see all 22):
    hsa-miR-376b hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-508-3p hsa-miR-421 hsa-miR-1304 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCASP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CASP3
    Predesigned siRNA for gene silencing in human, mouse, rat CASP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CASP3

    Clone
    Products:
         
    OriGene clones in human, mouse for CASP3 (see all 14)
    OriGene ORF clones in mouse, rat for CASP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CASP3 (NM_004346)
    Sino Biological Human cDNA Clone for CASP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASP3
    Addgene plasmids for CASP3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP3

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    eBioscience FlowRNA Probe Sets ( VA1-12156) for CASP3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CASP3_HUMAN, P42574: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion4
    nucleus4
    plasma membrane4
    cytoskeleton3
    endoplasmic reticulum3
    extracellular3
    lysosome2
    vacuole2
    endosome1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17167422
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CASP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CASP3 About   (see all 91)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TWEAK Pathway0.87
    Apoptotic Pathways Triggered By HIV10.42
    DR3 Signaling0.87
    Apoptosis through Death Receptors0.42
    TNFR1 Pathway0.56
    TRAIL Pathway0.40
    TNF Signaling0.55
    Fas Signaling0.35
    2Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    Caspase cascade in apoptosis0.42
    Apoptosis and survival FAS signaling cascades0.44
    Stimulation of the cell death response by PAK-2p340.00
    FAS pathway and Stress induction of HSP regulation0.44
    3Amyotrophic lateral sclerosis (ALS)
    Amyotrophic lateral sclerosis (ALS)0.63
    Pathogenesis of ALS0.31
    Amyotrophic lateral sclerosis (ALS)0.63
    4MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    5LT-BetaR Pathway
    Apoptosis and survival Lymphotoxin beta receptor signaling0.46
    LT-BetaR Pathway0.46


    Find genes that share SuperPaths with CASP3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CASP3
        Apoptosis Signaling Pathways
    Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CASP3 (see all 43)
        Caspase Cascade
    TWEAK Pathway
    14-3-3 Induced Apoptosis
    LT-BetaR Pathway
    Mitochondrial Apoptosis

    1 Cell Signaling Technology (CST) Pathway for CASP3
        Apoptosis and Autophagy

    2 Tocris Bioscience Pathways for CASP3
        Apoptosis Pathway
    VEGF Pathway

    Selected GeneGo (Thomson Reuters) Pathways for CASP3 (see all 10)
        G-protein signaling Regulation of RAC1 activity
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Signal transduction PTEN pathway
    G-protein signaling Regulation of CDC42 activity

    Selected BioSystems Pathways for CASP3 (see all 32)
        MAPK signaling pathway
    Apoptosis
    DNA damage response
    Apoptosis Modulation and Signaling
    SIDS Susceptibility Pathways

    4 Sino Biological Pathways for CASP3
        TNF Signaling
    EGFR Signaling Pathway
    p53 Pathway
    Death Receptor Signaling

    Selected Reactome Pathways for CASP3 (see all 12)
        Activation of DNA fragmentation factor
    Signaling by Hippo
    Caspase-mediated cleavage of cytoskeletal proteins
    NADE modulates death signalling
    Activation of caspases through apoptosome-mediated cleavage

    1 PharmGKB Pathway for CASP3
        Celecoxib Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for CASP3) (see all 25):
        MAPK signaling pathway
    p53 signaling pathway
    Apoptosis
    Natural killer cell mediated cytotoxicity
    TNF signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CASP3 (see all 20): 
              Parkinson's Disease in human mouse rat
              Lung Cancer in human mouse rat
              HIV Host Response in human mouse rat
              Autophagy in human mouse rat
              Alzheimer's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CASP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CASP3 (P425741, 2, 3 ENSP000003110324) via UniProtKB, MINT, STRING, and/or I2D (see all 272)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622582, 3, ENSP000002643354MINT-18746 I2D: score=4 STRING: ENSP00000264335
    APAF1O147272, 3, ENSP000003530594MINT-18036 I2D: score=3 STRING: ENSP00000353059
    ENSG00000228321P013753, ENSP000003928584I2D: score=1 STRING: ENSP00000392858
    TNFP013753, ENSP000003986984I2D: score=1 STRING: ENSP00000398698
    ENSG00000204490P013753I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 42):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001782B cell homeostasis IEA--
    GO:0001836release of cytochrome c from mitochondria IEA--
    GO:0006309apoptotic DNA fragmentation TAS--
    GO:0006508proteolysis IDA12888622
    GO:0006915apoptotic process TAS--

    Find genes that share ontologies with CASP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CASP3
    Selected ApexBio Compounds for CASP3 (see all 12)     About this table
    CompoundAction CAS #
    Apoptosis InhibitorCell-permeable caspase-3 inhibitor[54135-60-3]
    Caspase-3/7 Inhibitor ICell-permeable and irreversible inhibitor of caspase-3 and -7[220509-74-0]
    CisplatinChemotherapy agent, induces apoptosis[15663-27-1]
    PAC-1Procaspase-activating compound, activates procaspase-3 and converts it to caspase-3[315183-21-2]
    Q-VD-OphCell-permeable, irreversible pan-caspase inhibitor[1135695-98-5]
    VX-765 Novel Caspase-1 inhibitor[273404-37-8]
    Z-DEVD-FMKCell-permeable, and irreversible caspase-3 inhibitor[210344-95-9]
    Z-DQMD-FMKCell-permeable caspase-3 inhibitor--
    Z-FA-FMKEffector caspases 2, 3, 5, and 7--
    Z-VAD-FMKCell-permeable, irreversible pan-caspase inhibitor[187389-52-2]

    Compounds for CASP3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AZ 10417808Selective non-peptide caspase-3 inhibitor[331645-84-2]
    Z-DQMD-FMKCaspase-3 inhibitor--
    CisplatinPotent pro-apoptotic anticancer agent; activates caspase-3[15663-27-1]
    Z-DEVD-FMK Cell-permeable, irreversible caspase-3 inhibitor --
    Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor [187389-52-2]

    2 HMDB Compounds for CASP3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Butyric acid1-Butyrate (see all 25)107-92-616927016
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    10 DrugBank Compounds for CASP3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Minocycline-- 10118-90-8targetnegative modulator15304547 18977395 12112047 10888929 14588118 14568022
    5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid-- --target--17139284 17016423 10592235
    (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate-- --target--10592235
    (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate-- --target--10592235
    1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE-- --target--10592235
    2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID-- --target--10592235
    4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID-- --target--10592235
    N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide-- --target--10592235
    [N-(3-DIBENZYLCARBAMOYL-OXIRANECARBONYL)-HYDRAZINO]-ACETIC ACID-- --target--10592235
    methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate-- --target--10592235

    5 IUPHAR Ligands for CASP3 (Caspase 3)    About this table
    LigandTypeActionAffinityPubmed IDs
    PETCM
    ActivatorNone12522243
    AZ10417808
    InhibitorInhibition12490620
    Z-DEVD-FMK
    InhibitorInhibition9774422
    Z-DQMD-FMK
    InhibitorInhibition11301346
    PAC1
    ActivatorNone16936720

    Selected Novoseek inferred chemical compound relationships for CASP3 gene (see all 130)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adpribose 87.7 299 11118097 (2), 14966908 (2), 11239917 (2), 19121316 (2) (see all 99)
    phosphatidylserine 82.2 225 18492369 (6), 18441683 (3), 18155705 (3), 18925930 (2) (see all 99)
    dutp 81.3 79 12393527 (1), 15122710 (1), 15517578 (1), 16881058 (1) (see all 71)
    sp 600125 77.4 30 15130758 (2), 14766793 (1), 16923120 (1), 19248828 (1) (see all 27)
    3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 77 21 10655438 (1), 14970883 (1), 17850429 (1), 18199664 (1) (see all 15)
    n acetylcysteine 76.7 101 10428064 (2), 17603285 (2), 14726501 (2), 15816534 (2) (see all 76)
    z-vad-fmk 73.3 10 10229803 (1), 16326984 (1), 14999810 (1), 11389070 (1) (see all 9)
    ly294002 73.1 42 10658194 (2), 20010439 (2), 12606820 (2), 11804874 (1) (see all 35)
    oxygen 72.9 315 10388534 (4), 10998365 (3), 12853978 (3), 16310184 (2) (see all 99)
    sb 203580 72.7 42 18640003 (2), 10233770 (2), 10026138 (1), 12369731 (1) (see all 34)



    Find genes that share compounds with CASP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CASP3 gene (2 alternative transcripts): 
    NM_004346.3  NM_032991.2  

    Unigene Cluster for CASP3:

    Caspase 3, apoptosis-related cysteine peptidase
    Hs.141125  [show with all ESTs]
    Unigene Representative Sequence: NM_004346
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393585(uc003iwg.3) ENST00000308394(uc003iwh.3) ENST00000523916(uc003iwi.3)
    ENST00000517513 ENST00000393588 ENST00000447121
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CASP3 (see all 22):
    hsa-miR-376b hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-508-3p hsa-miR-421 hsa-miR-1304 hsa-let-7g
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    Addgene plasmids for CASP3 
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    eBioscience FlowRNA Probe Sets ( VA1-12156) for CASP3 

    Additional mRNA sequence: 

    AJ413269.1 AK291337.1 BC016926.2 BX647609.1 U13737.1 U13738.1 U26943.1 

    10 DOTS entries:

    DT.95168006  DT.101983465  DT.454515  DT.100798173  DT.121219812  DT.95167998  DT.97779743  DT.100798171 
    DT.121219810  DT.91647927 

    Selected AceView cDNA sequences (see all 231):

    BU619152 AW089940 AI359475 BU168163 BC016926 AI206265 AA243502 BU678741 
    AA011446 Z38379 AL135095 CR620420 AI858799 AI341242 CA307482 AA360736 
    AI419190 CA397890 BI493442 AU125557 AI917657 AA830607 AA651804 AA808562 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CASP3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b
    SP1:              -                                                                     
    SP2:              -     -     -                                                         
    SP3:              -                                                                     
    SP4:                          -                                                         


    ECgene alternative splicing isoforms for CASP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CASP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATGGTATC
    CASP3 Expression
    About this image


    CASP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Spinous Keratinocytes Stratified Epidermis
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Neural Tube (Nervous System)
             Telencephalon
    CASP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CASP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.141125

    UniProtKB/Swiss-Prot: CASP3_HUMAN, P42574
    Tissue specificity: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and
    skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune
    system

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CASP3 (see all 20): 
              Parkinson's Disease in human mouse rat
              Lung Cancer in human mouse rat
              HIV Host Response in human mouse rat
              Autophagy in human mouse rat
              Alzheimer's Disease in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CASP3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Casp31 , 5 caspase 31, 5 83.63(n)1
    86.64(a)1
      8 (26.39 cM)5
    123671  NM_001284409.11  NP_001271338.11 
     466174495 
    chicken
    (Gallus gallus)
    Aves CASP31 caspase 3, apoptosis-related cysteine peptidase 70.76(n)
    66.91(a)
      395476  NM_204725.1  NP_990056.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia D89784.12   -- 75.89(n)    D89784.1 
    zebrafish
    (Danio rerio)
    Actinopterygii casp32 caspase 3, apoptosis-related cysteine protease 74.69(n)   140621  AB047003.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ice3 apoptosis effector caspase 42(a)
    (best of 3)
      99C1   --


    ENSEMBL Gene Tree for CASP3 (if available)
    TreeFam Gene Tree for CASP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CASP3 gene
    CASP162  CASP62  CASP82  CASP122  CASP92  CASP72  CASP22  CASP142  
    CASP12  CASP52  CASP102  CASP42  
    6 SIMAP similar genes for CASP3 using alignment to 3 protein entries:     CASP3_HUMAN (see all proteins):
    DKFZp686N1815    CASP7    CASP6    CASP8    CASP9    CASP2

    Find genes that share paralogs with CASP3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CASP3
    PGOHUM00000244069


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CASP3 (see all 425)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494070231,2
    C--185548911(+) CAAAAC/TTGTCA 2 -- ut310--------
    rs10492531,2
    C,F,O,A,H--185548951(-) ACACAT/CAGCAT 2 -- ut31 ese322Minor allele frequency- C:0.10NS MN EA NA 2400
    rs85491,2
    C,F,H--185549008(-) CTCGCA/GTTTGT 2 -- ut31 ese319Minor allele frequency- G:0.04NS MN NA WA 2170
    rs69481,2
    C,F,A,H--185549130(-) TGAGCA/CCTCAG 2 -- ut31 ese326Minor allele frequency- C:0.26MN EA NS NA WA CSA 3472
    rs46476991,2
    C,H--185549158(-) TAGACG/AGCATC 2 -- ut31 ese35Minor allele frequency- A:0.00NS EA 580
    rs46476981,2
    C,F,H--185549217(-) AAATAG/ATAATG 2 -- ut3119Minor allele frequency- A:0.03NS EA NA MN 1940
    rs1891877451,2
    --185549285(+) GTACTA/TTGATT 2 -- ut310--------
    rs1475280701,2
    --185549368(+) ATGGCA/GCCCTG 2 -- ut310--------
    rs1140784161,2
    C,F--185549431(+) TCCTGC/TGTGGT 2 -- ut311Minor allele frequency- T:0.04WA 118
    rs46476971,2
    H--185549438(-) GCCATG/CGACCA 2 -- ut31 ese35Minor allele frequency- C:0.00NS EA 590

    HapMap Linkage Disequilibrium report for CASP3 (185548850 - 185570663 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CASP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830168CNV Loss17160897

    Human Gene Mutation Database (HGMD): CASP3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CASP3
    DNA2.0 Custom Variant and Variant Library Synthesis for CASP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600636    OMIM disorders: --

    17 diseases for CASP3:    
    About MalaCards
    nervous system cancer    cerebral hypoxia    kennedy's disease    fanconi anemia, complementation group a
    diffuse large b-cell lymphoma    skin squamous cell carcinoma    thoracic cancer    alexander disease
    mediterranean spotted fever    pneumococcal meningitis    krabbe disease    corticobasal degeneration
    idiopathic neutropenia    talipes equinovarus    myocardial infarction    ischemia
    lung cancer

    13 diseases from the University of Copenhagen DISEASES database for CASP3:
    Cancer     Vascular disease     Toxic encephalopathy     Brain disease
    Alzheimer's disease     Eye disease     Heart disease     Diabetes mellitus
    Huntington's disease     Kidney disease     Hyperglycemia     Lung disease
    Amyotrophic lateral sclerosis

    Find genes that share disorders with CASP3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CASP3 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 77.4 255 17185628 (3), 8619857 (2), 11414470 (2), 16111481 (2) (see all 99)
    tumors 75.6 567 15163235 (4), 14627349 (4), 17983518 (4), 12820420 (3) (see all 99)
    cancer 75.5 147 12854132 (7), 10772815 (5), 11593405 (2), 17150164 (2) (see all 99)
    leukemia 75.1 141 9787175 (3), 15192328 (3), 16077919 (3), 17089125 (3) (see all 99)
    promyelocytic leukemia 71.1 11 14555976 (1), 11844698 (1), 15816559 (1), 9489995 (1) (see all 10)
    colon cancer 68.4 35 10855553 (3), 15494216 (2), 17805550 (2), 11894121 (1) (see all 30)
    neurodegenerative diseases 65.6 5 19077216 (1), 19355923 (1), 14702258 (1), 15359610 (1) (see all 5)
    cell damage 65.2 31 14705839 (2), 12198374 (2), 12815112 (1), 16624439 (1) (see all 26)
    prostate cancer 60.7 41 10344723 (2), 11593405 (1), 12168853 (1), 15492266 (1) (see all 36)
    glioblastoma 59.4 22 15072442 (3), 18814044 (3), 15208263 (1), 18164543 (1) (see all 17)

    Genetic Association Database (GAD): CASP3
    Human Genome Epidemiology (HuGE) Navigator: CASP3 (40 documents)

    Export disorders for CASP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CASP3 gene, integrated from 10 sources (see all 5482):
    (articles sorted by number of sources associating them with CASP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone. (PubMed id 9045680)1, 2, 9 Mittl P.R.E.... Gruetter M.G. (J. Biol. Chem. 1997)
    2. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. (PubMed id 7983002)1, 2, 9 Fernandes-Alnemri T.... Alnemri E.S. (J. Biol. Chem. 1994)
    3. Polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population. (PubMed id 19531679)1, 4, 9 Xu H.L....Shu X.O. (amp 2009)
    4. Identification of polymorphisms in the Caspase-3 gene and their association with lung cancer risk. (PubMed id 18058802)1, 4, 9 Jang J.S....Park J.Y. (Mol. Carcinog. 2008)
    5. Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and Ich-1, involved in cellular apoptosis. (PubMed id 8780721)1, 3, 9 Tiso N....Danieli G.A. (Biochem. Biophys. Res. Commun. 1996)
    6. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. (PubMed id 8755496)1, 2, 9 Fernandes-Alnemri T.... Alnemri E.S. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    7. TP53 codon 72 polymorphism associated with prognosis in patients with advanced gastric cancer treated with paclitaxel and cisplatin. (PubMed id 19052714)1, 4, 9 Kim J.G....Yu W. (Cancer Chemother. Pharmacol. 2009)
    8. Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. (PubMed id 8696339)1, 2, 9 Goldberg Y.P.... Hayden M.R. (Nat. Genet. 1996)
    9. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    10. Common variants in CASP3 confer susceptibility to Kawasaki disease. (PubMed id 20423928)1, 4 Onouchi Y....Tanaka T. (Hum. Mol. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 836 HGNC: 1504 AceView: CASP3 Ensembl:ENSG00000164305 euGenes: HUgn836
    ECgene: CASP3 Kegg: 836 H-InvDB: CASP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CASP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CASP3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/casp3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CASP3 gene:
    Search GeneIP for patents involving CASP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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