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CASP3 Gene

protein-coding GIFtS: 74

GC04M185785

caspase 3, apoptosis-related cysteine peptidase
(Previous names: caspase 3, apoptosis-related cysteine protease )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Apopain ^³
CASP-3 ^³
CPP-32 ^³
CPP32 ^¹, ², ³, ⁵
CPP32B ^¹, ²
EC 3.4.22.56 ^³
OTTHUMP00000165054 ^²
SCA-1 ^², ³
Yama ^¹, ²
apopain ^¹, ²
procaspase3 ^²

Descriptions
Cysteine protease CPP32 ^², ³
PARP cleavage protease ^²
SREBP cleavage activity 1 ^², ³
Yama protein ^³
caspase 3 ^²
caspase 3, apoptosis-related cysteine peptidase ^²
caspase 3, apoptosis-related cysteine protease ^¹, ²

External Ids
HGNC: 1504¹
Entrez Gene: 836²
UniProtKB: P42574³
Ensembl: ENSG00000164305⁷

Search outside databases for aliases for CASP3 gene

Previous GC identifers: GC04M186576 GC04M186228 GC04M186133 GC04M186244 GC04M185924

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CASP3:

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase)

family. Sequential activation of caspases plays a central role in the execution-phase of cell

apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved

aspartic residues to produce two subunits, large and small, that dimerize to form the active

enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is

processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of

amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's

disease. Alternative splicing of this gene results in two transcript variants that encode the same

protein. [provided by RefSeq]

UniProtKB/Swiss-Prot: CASP3_HUMAN, P42574

Function: Involved in the activation cascade of caspases responsible for apoptosis execution. At

the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a

'216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins

(SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment

domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin

Gene Wiki entry for CASP3 (Caspase_3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CASP3 gene

Entrez Gene cytogenetic band: 4q34 Ensembl cytogenetic band: 4q35.1 HGNC cytogenetic band: 4q34

CASP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M185785: (about GC identifiers)

Start:	185,785,844 bp from pter
End:	185,807,623 bp from pter
Size:	21,780 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_022792.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CASP3_HUMAN, P42574 (See protein sequence)

Recommended Name: Caspase-3 precursor

Size: 277 amino acids; 31608 Da

Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed

by a 17 kDa (p17) and a 12 kDa (p12) subunit

Subcellular location: Cytoplasm

PDB structures from and Proteopedia :

1CP3 (3D)

1GFW (3D)

1I3O (3D)

1NME (3D)

1NMQ (3D)

1NMS (3D)

1PAU (3D)

1QX3 (3D)

1RE1 (3D)

1RHJ (3D)

1RHK (3D)

1RHM (3D)

1RHQ (3D)

1RHR (3D)

1RHU (3D)

2C1E (3D)

2C2K (3D)

2C2M (3D)

2C2O (3D)

2CDR (3D)

2CJX (3D)

2CJY (3D)

2CNK (3D)

2CNL (3D)

2CNN (3D)

2CNO (3D)

2DKO (3D)

2H5I (3D)

2H5J (3D)

2H65 (3D)

2J30 (3D)

2J31 (3D)

2J32 (3D)

2J33 (3D)

3DEH (3D)

3DEI (3D)

3DEJ (3D)

3DEK (3D)

3EDQ (3D)

3GJQ (3D)

3GJR (3D)

3GJS (3D)

3GJT (3D)

Secondary accessions: Q96AN1 Q96KP2

Post-translational modifications:

Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits.

Additional processing of the propeptides is likely due to the autocatalytic activity of the

activated protease. Active heterodimers between the small subunit of caspase-7 protease and the

large subunit of caspase-3 also occur and vice versa¹

S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated

upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase

activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase

zymogen to its active subunits, but also by stimulating the denitrosylation of its active site

thiol¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_004337.2 NP_116786.1

ENSEMBL proteins:

ENSP00000296745 ENSP00000377210 ENSP00000311032 ENSP00000377213

Human Recombinant Proteins

	Invitrogen human recombinant proteins for CASP3
	Millipore Purified and/or Recombinant CASP3 Protein
	Sigma-Aldrich Proteins for CASP3
	R&D Systems Recombinant & Natural Proteins for CASP3 (Caspase-3)
	Enzo Life Sciences proteins for CASP3
	Recombinant Proteins from Abcam (active Caspase 3, active + pro Caspase 3, pro Caspase 3, Caspase 3)
	Human Recombinant Proteins from Abnova (CASP3)

OriGene Purified Recombinant Human Proteins (see all 2): CASP3

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005654	nucleoplasm	EXP	9108473
GO:0005730	NOT nucleolus	IDA	18029348
GO:0005737	cytoplasm	IEA	--
GO:0005739	mitochondrion	IDA	18029348

About this table

Antibodies for CASP3:

	Invitrogen Antibodies for CASP3
	Millipore Mono- and Polyclonal Antibodies for the study of CASP3
	Sigma-Aldrich Antibody Arrays and Antibodies for CASP3
	R&D Systems Antibodies for CASP3 (Caspase-3)
	Cell Signaling Technology (CST) Antibodies for CASP3 (Caspase-3)
	Antibodies from Abcam (active Caspase 3, active + pro Caspase 3, pro Caspase 3, Caspase 3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CASP3)
	Novus Biologicals Antibodies for CASP3

Assays for CASP3:

	Invitrogen Assays for CASP3
	Millipore Kits and Assays for the Analysis of CASP3
	R&D Systems ELISAs for CASP3 (Caspase-3) (see all)
	Cell Signaling Technology (CST) Sandwich ELISA Kits for CASP3 (Caspase-3)
	Enzo Life Sciences assays for CASP3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P42574

ProtoNet protein and cluster: P42574

2 Blocks protein families:

IPB001309 Caspase-1

IPB002398 Interleukin-1B converting enzyme signature

UniProtKB/Swiss-Prot: CASP3_HUMAN, P42574

Similarity: Belongs to the peptidase C14A family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CASP3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CASP3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_032991

Applied Biosystems Silencer® siRNAs for CASP3

Sigma-Aldrich siRNA and siRNA Panels for CASP3

Sigma-Aldrich shRNA Panels and shRNA for CASP3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CASP3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004346
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004346
untagged cDNA clones in CMV expression vector (see all 4): NM_004346

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_032991

UniProtKB/Swiss-Prot: CASP3_HUMAN, P42574

Function: Involved in the activation cascade of caspases responsible for apoptosis execution. At

the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a

'216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins

(SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment

domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin

Catalytic activity: Strict requirement for an Asp residue at positions P1 and P4. It has a

preferred cleavage sequence of Asp-Xaa-Xaa-Asp- - with a hydrophobic amino-acid residue at P2 and

a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position

Enzyme regulation: Inhibited by isatin sulfonamides

Enzyme Number (IUBMB): EC 3.4.22.56

Genatlas biochemistry entry for CASP3:

caspase 3,effector,cysteine containing aspartate-specific protease CPP32,activated by

CASP9,cleaving specifically CDKN1A,alpha-fodrin (SPTAN1), gelsolin (GSN),stored in the

mitochondrial intermembrane space and released into cytosol after appropriate apoptotic

stimuli,promoting CD95/APO1/fas mediated apoptosis,homolog to C elegans Ced-3 and mammalian

interleukin 1 beta convertase (IL1BC),including two isoforms alpha and beta

15/21 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Casp3) (see all 21 ):

	behavior/neurological	cellular	craniofacial	endocrine/exocrine gland
growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system
lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	nervous system	pigmentation

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004197	cysteine-type endopeptidase activity	TAS	10942389
GO:0004861	cyclin-dependent protein kinase inhibitor activity	IEA	--
GO:0005515	protein binding	IPI	9736630
GO:0008233	peptidase activity	IDA	9353287

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/18 Sigma-Aldrich "Your Favorite Gene" Pathways for CASP3 (Your Favorite Gene powered by Ingenuity) (see all 18 )

Molecular Mechanisms of Cancer
Lysine Degradation
Parkinson's Signaling
Endoplasmic Reticulum Stress Pathway
CD27 Signaling in Lymphocytes

GeneDecks CASP3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CASP3

5/321 Interacting proteins for CASP3 (ENSP00000311032³ P42574^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 321 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BIRC2	Q13490¹	STRING (score=.998) EBI-524064, EBI-514538
BIRC7	Q96CA5¹	STRING (score=.994) EBI-524064, EBI-517623
XIAP	P98170²	STRING (score=.999) MINT-13839 MINT-13838
AKT1	P31749²	STRING (score=.984) MINT-4820691
AKT2	P31751²	STRING (score=.773) MINT-4820707

About this table

5/21 Gene Ontology (GO) biological process terms (links to tree view) (see all 21 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001782	B cell homeostasis	IEA	--
GO:0001836	release of cytochrome c from mitochondria	IEA	--
GO:0006309	DNA fragmentation during apoptosis	IEA	--
GO:0006508	proteolysis	IDA	12888622
GO:0006917	induction of apoptosis	TAS	7983002

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CASP3

Sigma-Aldrich Small Molecules for CASP3:

Inhibitor

Compounds for CASP3 available from Tocris Bioscience

Compound	Action	CAS number
PAC 1	Activator of procaspase-3; proapoptotic	[315183-21-2]
Ivachtin	Potent caspase-3 inhibitor
PETCM	Activator of caspase-3	[10129-56-3]
AZ 10417808	Selective non-peptide caspase-3 inhibitor	[331645-84-2]
Z-DQMD-FMK	Caspase-3 inhibitor

About this table

10/27 Novoseek chemical compound relationships for CASP3 gene (see all 27 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dutp	80.83	60	12393527 (1), 15122710 (1), 15517578 (1), 16881058 (1) (see all 56)
sp 600125	75.54	26	15130758 (2), 14766793 (1), 16923120 (1), 19248828 (1) (see all 23)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide	75.07	15	10655438 (1), 14970883 (1), 17850429 (1), 18199664 (1) (see all 11)
ceramide	73.17	138	8898109 (4), 12511568 (3), 14871831 (3), 11042671 (3) (see all 84)
oxygen	71.42	277	10388534 (4), 10998365 (3), 12853978 (3), 16310184 (2) (see all 99)
sbdp	70.79	18	8920967 (2), 17335970 (1), 17562168 (1), 16949208 (1) (see all 8)
hoechst 33342	70.28	12	12576187 (2), 18648526 (1), 11008984 (1), 17963107 (1) (see all 11)
pd 98,059	67.47	29	17161815 (2), 18361842 (2), 9506973 (1), 11279260 (1) (see all 26)
polyadenosine diphosphate ribose	66.91	17	15388586 (1), 15802533 (1), 15970928 (1), 18440520 (1) (see all 16)
wortmannin	62.11	28	10658194 (3), 10200474 (3), 11804874 (1), 15142122 (1) (see all 17)

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1 PharmGKB drug compound relationship for CASP3 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
ace inhibitors	FA	12785010

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CASP3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CASP3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_032991

Sigma-Aldrich siRNA and siRNA Panels for CASP3

Sigma-Aldrich shRNA Panels and shRNA for CASP3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004346 NM_032991

REFSEQ mRNAs for CASP3 gene (2 alternative transcripts):

NM_004346.3 NM_032991.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004346 NM_032991

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004346
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004346
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_004346

Additional cDNA sequence:

AJ413269.1 AK291337.1 BC016926.2 BX647609.1 CR620420.1 U13737.1 U13738.1 U26943.1

11 DOTS entries:

DT.95168006 DT.101983465 DT.454515 DT.70105468 DT.100798173 DT.121219812 DT.95167998 DT.91647927

DT.97779743 DT.100798171 DT.121219810

24/231 AceView cDNA sequences (see all 231 ):

AL135095 BF724959 AA243502 BI493442 BM673029 CA425368 BM818717 AA808562

AA651804 BU619152 CD703763 CB160172 AA961269 BU678741 CA397890 Z38379

U26943 BC016926 AI079900 AL602756 AI359475 AA830607 AI341242 AI419190

highest scoring ESTs for CASP3:

U13737 AL703503 AU076852 AU127028 AU127381 AU127408 AU133051 BC016926 BF966141 BU597037

Unigene Cluster for CASP3:

Caspase 3, apoptosis-related cysteine peptidase

Hs.141125 [show with all ESTs]

Unigene Representative Sequence: NM_004346

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CASP3

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b
SP1:					-
SP2:					-		-		-
SP3:					-
SP4:									-

About this scheme

ECgene alternative splicing isoforms for CASP3

4 Ensembl transcripts including schematic representations:

ENST00000352650 ENST00000393585 ENST00000308394 ENST00000393588

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CASP3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CASP3

¹ / ² / ³

6 probe-sets matching CASP3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36143_at²^{, 3}	U95-A	1	1.00	1.00	0.79	0.98	U13737	1.00	1.00	1.00	1
76948_at*²^{, 3}	U95-E	1	--	--	0.55	1.03	AI668623	0.20	1.00	0.72	1
202763_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004346	0.60	1.00	0.82	1
236729_at*²^{, 3}	U133-B	NULL	0.00	0.00	--	--	AI668623	0.20	1.00	0.72	1
202763_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
236729_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAATGGTATC

SOURCE GeneReport for Unigene cluster: Hs.141125
Expression variation in blood from EXPOLDB for CASP3
UniProtKB/Swiss-Prot: CASP3_HUMAN, P42574
Tissue specificity: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in
brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in
cells of the immune system

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CASP3 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CASP3¹	--	caspase 3, apoptosis-related cysteine peptidase	89.53(n) 89.17(a)	403567 NM_001003042.1 NP_001003042.1
chimpanzee (Pan troglodytes)	CASP3¹	--	caspase 3, apoptosis-related cysteine peptidase	99.52(n) 99.64(a)	461669 NM_001012433.1 NP_001012435.1
cow (Bos taurus)	CASP3¹	--	caspase 3, apoptosis-related cysteine peptidase	82.09(n) 79.1(a)	408016 XM_001256573.1 XP_001256574.1
rat (Rattus norvegicus)	Casp3¹	--	caspase 3, apoptosis related cysteine protease	84.84(n) 89.17(a)	25402 NM_012922.2 NP_037054.1
mouse (Mus musculus)	Casp3^{1, 5}	8 (26.00 cM)⁵	caspase 3^{1, 5}	83.63(n)¹ 86.64(a)¹	12367¹ NM_009810.2¹ NP_033940.1¹ AK049043⁵ AK080651⁵ (see all 17)

About this table Species with no ortholog for CASP3

ENSEMBL Gene Tree for CASP3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CASP3 gene

CASP6² CASP7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/175 NCBI SNPs in CASP3 are shown (see all 175 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 104)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1049253^1,2	A,C,F,H,O	185785945(-)	`ACACAT/CAGCAT`	2	--	ut3¹ ese³		13	NS MN EU EA WA NA	1332
	rs6948^1,2	A,C,F,H	185786124(-)	`TGAGCA/CCTCAG`	2	--	ut3¹ ese³		10	MN EA EU NS CSAM	2342
	rs1049216^1,2	C,F	185787083(-)	`AGTAAC/TGAATT`	2	--	ut3¹		18	EA NS MN NA CSAM	3082
	rs1049210^1,2	C,H	185789219(-)	`GTGGAG/TGCCGA`	2	E/D	mis¹ ese³		10	MN CSAM EA EU WA	1008
--	rs4647694^1,2	C,F	185787116(-)	`TTTTCA/CAGTAA`	2	--	ut3¹ ese³		12	NS MN CSAM EA	1232
	rs8549^1,2	C,F	185786002(-)	`CTCGCA/GTTTGT`	2	--	ut3¹ ese³		11	NS MN NA	1158
--	rs4647698^1,2	C,F	185786211(-)	`AAATAG/ATAATG`	2	--	ut3¹		9	NS NA MN CSAM EA	716
--	rs4647696^1,2	F	185786851(-)	`ATAAT-/AATGTTTA`	2	--	ut3¹		1	NS	168
	rs4647695^1,2	H	185786946(-)	`ATACAC/TGGATG`	2	--	ut3¹ ese³		5	NS EU EA WA	588
	rs35578277^1,2	F	185793555(-)	`CATACA/GTGGAA`	2	H/R	mis¹		5	MN CSAM EA	400

About this table

HapMap Linkage Disequilibrium images for CASP3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600636

10/94 Novoseek disease relationships for CASP3 gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	76.98	231	17185628 (3), 8619857 (2), 11414470 (2), 16111481 (2) (see all 99)
leukemia	74.53	133	9787175 (3), 15192328 (3), 16077919 (3), 17089125 (3) (see all 99)
tumors	74.26	480	15163235 (4), 14627349 (4), 17983518 (4), 12820420 (3) (see all 99)
cancer	73.62	125	12854132 (7), 10772815 (5), 11593405 (2), 17150164 (2) (see all 95)
promyelocytic leukemia	71.37	9	14555976 (1), 11844698 (1), 15816559 (1), 9489995 (1) (see all 8)
colon cancer	66.64	34	10855553 (3), 15494216 (2), 17805550 (2), 11894121 (1) (see all 29)
neurodegenerative diseases	65.03	5	19077216 (1), 19355923 (1), 14702258 (1), 15359610 (1) (see all 5)
cell damage	62.42	26	14705839 (2), 12198374 (2), 12815112 (1), 16624439 (1) (see all 21)
glioblastoma	59.03	18	15072442 (3), 18814044 (3), 15208263 (1), 18164543 (1) (see all 13)
prostate cancer	58.51	37	10344723 (2), 11593405 (1), 12168853 (1), 15492266 (1) (see all 32)

About this table

Human Gene Mutation Database: CASP3
Human Genome Epidemiology Navigator: CASP3 (14 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/3636 PubMed articles for CASP3 gene (see all 3636 ):

Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone. (PubMed id 9045680)^{1, 3, 4} Mittl P.R.E.... Gruetter M.G. (1997)
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. (PubMed id 7983002)^{1, 3, 4} Fernandes-Alnemri T.... Alnemri E.S. (1994)
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. (PubMed id 8755496)^{1, 3, 4} Fernandes-Alnemri T.... Alnemri E.S. (1996)
Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and Ich-1, involved in cellular apoptosis. (PubMed id 8780721)^{1, 2, 3} Tiso N....Danieli G.A. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality. (PubMed id 10821855)^{3, 4} Lee D.... Nuttall M.E. (2000)
The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis. (PubMed id 8673606)^{3, 4} Rotonda J.... Becker J.W. (1996)
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. (PubMed id 8696339)^{3, 4} Goldberg Y.P.... Hayden M.R. (1996)
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. (PubMed id 7596430)^{3, 4} Nicholson D.W....Miller D.K. (1995)
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. (PubMed id 7774019)^{3, 4} Tewari M.... Dixit V.M. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 836	HGNC: 1504	AceView: CASP3	Ensembl:ENSG00000164305	euGenes: HUgn836
ECgene: CASP3	H-InvDB: CASP3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CASP3	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/casp3/

Licensable Technologies for CASP3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CASP3:

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Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
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Antibodies & Assays for CASP3 (Caspase-3)

	Recombinant Proteins (active Caspase 3, active + pro Caspase 3, pro Caspase 3, Caspase 3)
	Antibodies (active Caspase 3, active + pro Caspase 3, pro Caspase 3, Caspase 3)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for CASP3

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	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CASP3

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CASP3 Gene

protein-coding GIFtS: 74

Aliases &
Descriptions
for CASP3

Summaries
for CASP3

Genomic Location
for CASP3

Proteins
for CASP3

Protein Domains/
Families
for CASP3

Gene Function
for CASP3

Pathways & Interactions
for CASP3

Drugs & Compounds
for CASP3

Transcripts
for CASP3

Expression
for CASP3

Orthologs
for CASP3

Paralogs
for CASP3

SNPs/Variants
for CASP3

Disorders & Mutations
for CASP3

Medical News
for CASP3

Publications
for CASP3

Search for CASP3

Genome Databases showing CASP3

Other Databases showing CASP3

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for CASP3

Services
for CASP3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CASP3 Gene

protein-coding GIFtS: 74

Aliases & Descriptionsfor CASP3

Summariesfor CASP3

Genomic Locationfor CASP3

Proteinsfor CASP3

Protein Domains/Familiesfor CASP3

Gene Functionfor CASP3

Pathways & Interactionsfor CASP3

Drugs & Compoundsfor CASP3

Transcriptsfor CASP3

Expression for CASP3

Orthologsfor CASP3

Paralogsfor CASP3

SNPs/Variantsfor CASP3

Disorders & Mutationsfor CASP3

Medical Newsfor CASP3

Publicationsfor CASP3

Search for CASP3

Genome Databases showing CASP3

Other Databases showing CASP3

Specialized Databases showing CASP3

Licensable Technologiesfor CASP3

Servicesfor CASP3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CASP3

Summaries
for CASP3

Genomic Location
for CASP3

Proteins
for CASP3

Protein Domains/
Families
for CASP3

Gene Function
for CASP3

Pathways & Interactions
for CASP3

Drugs & Compounds
for CASP3

Transcripts
for CASP3

Expression
for CASP3

Orthologs
for CASP3

Paralogs
for CASP3

SNPs/Variants
for CASP3

Disorders & Mutations
for CASP3

Medical News
for CASP3

Publications
for CASP3

Licensable Technologies
for CASP3

Services
for CASP3