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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CASP2 Gene

protein-coding GIFtS: 67
GCID: GC07P142985

caspase 2, apoptosis-related cysteine peptidase

(Previous names: neural precursor cell expressed, developmentally down-regulated...)
(Previous symbol: NEDD2)

Explore 49 diseases affiliated with
CASP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Caspase 2, Apoptosis-Related Cysteine Peptidase¹ ²		CASP-2² ³
ICH1¹ ² ³ ⁵		NEDD-2² ³
NEDD2¹ ² ³ ⁵		EC 3.4.22.55³ ⁸
PPP1R57¹ ²		Neural Precursor Cell Expressed, Developmentally Down-Regulated 2¹
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 2² ³		Caspase-2¹
Protease ICH-1² ³		Protein Phosphatase 1, Regulatory Subunit 57²

External Ids:	HGNC: 1503¹	Entrez Gene: 835²	Ensembl: ENSG00000106144⁷	OMIM: 600639⁵	UniProtKB: P42575³

Export aliases for CASP2 gene to outside databases

Previous GC identifers: GC07P141311 GC07P142379 GC07P142456 GC07P142502 GC07P142695 GC07P137322

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CASP2:

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis

through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced

cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene

may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe

epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

(provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575

Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either

activating some proteins required for cell death or inactivating proteins necessary for cell survival

summary for CASP2:

Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of

apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and

effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with,

upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector

caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the

executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase

Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors

such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For

example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form

part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by

inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of

many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory

disease.

Gene Wiki entry for CASP2 (Caspase 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CASP2 gene promoter:
SRF TBP AML1a SRF (504 AA) Meis-1b E47 TFIID Meis-1a ZIC2/Zic2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CASP2 promoter sequence

Search SABiosciences Chromatin IP Primers for CASP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34-q35 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q34-q35

CASP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CASP2 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P142985: view genomic region (about GC identifiers)

Start:	142,985,308 bp from pter	End:	143,004,789 bp from pter
Size:	19,482 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 142,387,518-142,406,902

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575 (See protein sequence)

Recommended Name: Caspase-2 precursor

Size: 452 amino acids; 50685 Da

Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and

a p12 subunit. Interacts with LRDD

Sequence caution: Sequence=AAA58959.1; Type=Erroneous initiation; Sequence=AAO25653.1; Type=Erroneous initiation;

Sequence=AAP22346.1; Type=Erroneous initiation; Sequence=AAP22349.1; Type=Erroneous initiation; Sequence=BAD92877.1;

Type=Erroneous initiation;

6/9 PDB 3D structures from and Proteopedia for CASP2 (see all 9):

1PYO (3D)

2P2C (3D)

3R5J (3D)

3R6G (3D)

3R6L (3D)

3R7B (3D)

Secondary accessions: A8K5F9 D3DXD6 E9PDN0 P42576 Q59F21 Q7KZL6 Q86UJ3 Q9BUP7 Q9BZK9 Q9BZL0

Alternative splicing: 3 isoforms: P42575-1 P42575-2 P42575-3 (May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death)

Explore the universe of human proteins at neXtProt for CASP2: NX_P42575

Post-translational modifications:

The mature protease can process its own propeptide, but not that of other caspases¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P42575

4/6 DME Specific Peptides for CASP2 (P42575) (see all 6)

GSFSQNVE

LNLLPKRGP

SPGCEESDA

DGKLLQLQE

CASP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001215.1 NP_116764.2 NP_116765.2

ENSEMBL proteins:

ENSP00000312664 ENSP00000376656 ENSP00000340030

Reactome Protein details: P42575
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant CASP2 Protein
	R&D Systems Recombinant & Natural Proteins for CASP2 (Caspase-2)
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	Novus Biologicals CASP2 Proteins Novus Biologicals CASP2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CASP2

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005624	membrane fraction	--	--
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	--	--

CASP2 for ontologies About GeneDecksing

CASP2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CASP2
	R&D Systems Antibodies for CASP2 (Caspase-2)
	Cell Signaling Technology (CST) Antibodies for CASP2
	OriGene Antibodies (see all 3): CASP2 OriGene Custom Antibody Services for CASP2
	GenScript Custom Superior Antibodies Services for CASP2
	Novus Biologicals CASP2 Antibodies
	Abcam antibodies for CASP2
	Uscn Antibodies for CASP2
	ThermoFisher Antibodies for CASP2

Assay Products for CASP2:

	EMD Millipore Kits and Assays for the Analysis of CASP2
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Kinase Activity Assays & Reagents for CASP2 (Caspase-2)
	GenScript CASP2-Activity-based Protease Assay for Compound Screening
	Enzo Life Sciences assays for CASP2
	Uscn ELISAs and CLIAs for CASP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CASP2 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR001309 Pept_C14_ICE_p20

IPR011029 DEATH-like_dom

IPR017350 Caspase_IL-1_beta

IPR002138 Pept_C14_p10

IPR015917 Pept_C14_p45_core

Graphical View of Domain Structure for InterPro Entry P42575

ProtoNet protein and cluster: P42575

3 Blocks protein families:

IPB001309 Caspase-1

IPB001315 CARD interaction domain

IPB002398 Interleukin-1B converting enzyme signature

UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575

Similarity: Belongs to the peptidase C14A family

Similarity: Contains 1 CARD domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575

Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either

activating some proteins required for cell death or inactivating proteins necessary for cell survival

Catalytic activity: Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity

and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp- -

Genatlas biochemistry entry for CASP2:

caspase 2,cysteine containing aspartate-specific protease,stored in the mitochondrial intermembrane space and released

into cytosol after appropriate apoptotic stimuli,expressed in neural precursor cell,developmentally

down-regulated,promoting apoptosis,Nedd 2 murine homolog,mammalian interleukin 1 beta convertase

Enzyme Number (IUBMB): EC 3.4.22.55¹ ²

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CASP2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CASP2
		8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate CASP2 (see all 38):
		hsa-miR-194* hsa-miR-1914* hsa-miR-106a hsa-miR-449a hsa-miR-342-3p hsa-miR-93 hsa-miR-28-5p hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: CASP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CASP2 (see all 7) OriGene shRNA RFP: CASP2 OriGene siRNA: CASP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASP2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CASP2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CASP2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CASP2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CASP2 (NM_032982)
		Sino Biological Human cDNA Clone for CASP2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASP2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CASP2
		Search LifeMap BioReagents cell lines for CASP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004197	cysteine-type endopeptidase activity	IDA	9044836
GO:0005515	protein binding	IPI	11156409
GO:0019899	enzyme binding	ISS	11076957
GO:0019904	protein domain specific binding	IPI	9044836

CASP2 for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for CASP2:

Cell division defect	Decreased POU5F1-GFP protein e	Increased 8N DNA content	Increased cell death HMECs cel
Increased cell death in breast

Animal Models:
Mouse knock-outs for CASP2: Casp2^tm1Yuan Casp2^tm1Vaux
7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Casp2):

cellular	endocrine/exocrine gland	hematopoietic system	immune system	mortality/aging
nervous system	reproductive system

CASP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TWEAK Pathway

8/9 pathways (see all 9)
TNFR1 Pathway	0.53	TNF Signaling	0.40
GITR Pathway	0.46	Apoptosis through Death Receptors	0.32
HIV-1 Nef- Negative effector of Fas and TNF-alpha	0.42	Apoptosis Modulation by HSP70	0.30
Apoptosis and survival TNFR1 signaling pathway	0.40	Fas Signaling	0.29

Apoptosis and survival_Caspase cascade

Apoptosis and survival_Caspase cascade	1.00	Apoptosis and survival FAS signaling cascades	0.44
Apoptosis and survival Caspase cascade	1.00	Caspase cascade in apoptosis	0.42
Apoptosis and survival_FAS signaling cascades	0.44

Apoptosis and survival_Apoptotic TNF-family pathways

	Apoptosis and survival_Apoptotic TNF-family pathways	1.00			Apoptosis Signaling Pathways	0.35
	Apoptosis and survival Apoptotic TNF-family pathways	1.00

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

1.00

NOD1/2 Signaling Pathway

0.69

Immune System

Immune System

1.00

Innate Immune System

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for CASP2

	Apoptosis and survival TNFR1 signaling pathway
	Apoptosis and survival Caspase cascade
	Apoptosis and survival FAS signaling cascades
	Apoptosis and survival Apoptotic TNF-family pathways

1 R&D Systems Pathway for CASP2

Apoptosis Signaling Pathways

5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CASP2 (see all 17)

	Caspase Cascade
	14-3-3 Induced Apoptosis
	DHA Signaling
	Endothelin-1 Signaling Pathway
	TNF-Induced Apoptosis Implicating Sphingolipids

1 Cell Signaling Technology (CST) Pathway for CASP2

Apoptosis and Autophagy

4 GeneGo (Thomson Reuters) Pathways for CASP2

	Apoptosis and survival Apoptotic TNF-family pathways
	Apoptosis and survival Caspase cascade
	Apoptosis and survival FAS signaling cascades
	Apoptosis and survival TNFR1 signaling pathway

5/8 BioSystems Pathways for CASP2 (see all 8)

	Apoptosis Modulation and Signaling
	MAPK signaling pathway
	Apoptosis
	Parkinsons Disease Pathway
	Apoptosis Modulation by HSP70

5/9 Reactome Pathways for CASP2 (see all 9)

	Cell death signalling via NRAGE, NRIF and NADE
	NADE modulates death signalling
	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
	p75 NTR receptor-mediated signalling
	Signal Transduction

CASP2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CASP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/55 Interacting proteins for CASP2 (P42575^{1, 2, 3} ENSP00000312664⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 55)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CRADD	P78560¹^,²^,³, ENSP00000327647⁴	EBI-520342,EBI-520375 MINT-17424 I2D: score=6 STRING: ENSP00000327647
PRKDC	P78527¹^,³, ENSP00000313420⁴	EBI-520342,EBI-352053 I2D: score=1 STRING: ENSP00000313420
EEF1A1	P68104²^,³	MINT-8250645 I2D: score=2
RAI1	Q7Z5J4²^,³	MINT-8250656 I2D: score=2
GRB2	P62993²^,³, ENSP00000339007⁴	MINT-8256547 I2D: score=2 STRING: ENSP00000339007

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001554	luteolysis	IEA	--
GO:0003407	neural retina development	IEA	--
GO:0006508	proteolysis	IEA	--
GO:0006915	apoptotic process	TAS	--
GO:0006917	induction of apoptosis	IEA	--

CASP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CASP2 for compounds About GeneDecksing

EMD Millipore small molecules for CASP2:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for CASP2

Compounds for CASP2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Z-VDVAD-FMK	Irreversible caspase-2 inhibitor	--
Ac-LEHD-AFC	Fluorogenic caspase substrate	[210345-03-2]
Z-VAD-FMK	Cell-permeable, irreversible caspase inhibitor	--

10/61 Novoseek chemical compound relationships for CASP2 gene (see all 61) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
1,4-anthraquinone	73.1	1	15037204 (1)
wp631	65.1	2	16319532 (1), 16735036 (1)
phenoxodiol	61.2	1	16388521 (1)
phosphatidylserine	55.1	5	16215683 (1), 16243317 (1), 9345052 (1), 17893514 (1) (see all 5)
etoposide	53.4	23	15817479 (4), 12065594 (4), 19549763 (2), 19488905 (2) (see all 9)
adpribose	52.3	1	9128256 (1)
rottlerin	51.1	7	18413747 (7)
polyadenosine diphosphate ribose	49.2	2	12351403 (1), 17599497 (1)
z-vad-fmk	46.9	1	16545898 (1)
ceramide	45.7	12	15817479 (4), 11368523 (2), 17666435 (2), 15262979 (1) (see all 6)

Search CenterWatch for drugs/clinical trials and news about CASP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CASP2 gene (3 alternative transcripts):

NM_001224.4 NM_032982.3 NM_032983.3

Unigene Cluster for CASP2:

Caspase 2, apoptosis-related cysteine peptidase

Hs.368982 [show with all ESTs]

Unigene Representative Sequence: NM_032982

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000310447(uc003wco.3 uc003wcp.3 uc011kta.2 uc003wcq.3 uc011ktb.2)

ENST00000392925 ENST00000350623 ENST00000493642 ENST00000481483 ENST00000472067

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CASP2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CASP2
		8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate CASP2 (see all 38):
		hsa-miR-194* hsa-miR-1914* hsa-miR-106a hsa-miR-449a hsa-miR-342-3p hsa-miR-93 hsa-miR-28-5p hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: CASP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CASP2 (see all 7) OriGene shRNA RFP: CASP2 OriGene siRNA: CASP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASP2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CASP2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CASP2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CASP2 (NM_032982)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASP2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CASP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CASP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CASP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASP2

Additional cDNA sequence:

AF314174.1 AK096245.1 AK291274.1 AK303265.1 BC002427.2 BT007240.1 CR541748.1 U13021.1

13 DOTS entries:

DT.454941 DT.121119586 DT.75168038 DT.216001 DT.87000033 DT.86839154 DT.100835221 DT.98083042

DT.100790400 DT.121119475 DT.121119587 DT.95195341 DT.97823615

24/186 AceView cDNA sequences (see all 186):

BU621082 AW505293 CR541748 BU688186 AA233693 BM802814 BF057560 AA233657

CR591430 BQ421870 AW951422 AW502916 BF475907 AA298416 AA243486 U13021

AA774648 BQ447606 BU733273 NM_032984 CD671883 CD672270 AA233233 BG392096

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CASP2 (see all 10) About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11a	·	11b	·	11c	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17a	·	17b	·
SP1:																					-										-										-		-
SP2:											-										-										-								-		-		-
SP3:																	-		-		-		-								-								-		-		-
SP4:											-						-		-		-		-								-
SP5:					-		-		-		-										-

ExUns:	17c	·	17d	·	17e
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CASP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CASP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCCCTAGCA

About this image
See CASP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CASP2

SOURCE GeneReport for Unigene cluster: Hs.368982

UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575

Tissue specificity: Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In

adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver

and skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Arrays including CASP2 (see all 7):

Cancer PathwayFinder in human mouse rat

p53 Signaling Pathway in human mouse rat

TNF Ligands & Receptors in human mouse rat

Apoptosis 384HT in human mouse rat

Apoptosis in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CASP2 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CASP2¹	caspase 2, apoptosis-related cysteine peptidase	66.98(n) 71.56(a)		395857 NM_001167701.1 NP_001161173.1
lizard (Anolis carolinensis)	Reptilia	CASP2⁶	--	70(a)	1 ↔ 1	GL343391.1(930536-958545)
African clawed frog (Xenopus laevis)	Amphibia	xCaspase-2²	caspase-2	76.4(n)		AB038168.1
zebrafish (Danio rerio)	Actinopterygii	casp2²	caspase 2, apoptosis-related cysteine protease	71.78(n)		373118 AI815376.1
fruit fly (Drosophila melanogaster)	Insecta	Nc⁶ Dredd⁶	Death related ced-3/Nedd2-like protein	14(a) 12(a)	possible ortholog 1 ↔ many	3L(9961579-9964102) X(527553-529760)
worm (Caenorhabditis elegans)	Secernentea	ced-3¹	Protein CED-3	46.45(n) 36.39(a)		178272 NM_070137.4 NP_502538.1

ENSEMBL Gene Tree for CASP2 (if available)
TreeFam Gene Tree for CASP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CASP2 gene

CASP16² CASP6² CASP8² CASP12² CASP9² CASP7² CASP3² CASP14²

CASP1² CASP5² CASP10² CASP4²

6 SIMAP similar genes for CASP2 using alignment to 2 protein entries: CASP2_HUMAN (see all proteins):

CRADD DKFZp586A181 CASP9 CASP14 CASP7 CASP3

CASP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4647280^1,2	C,F,H,	--	142386383(+)	`TTAGAA/TCCCTT`	2	--	us2k¹		2		NS	294
rs12433^1,2	C	--	142386465(-)	`tgtgcC/Actcgt`	2	--	us2k¹		2		NA	4
rs4647281^1,2	C,F,H,	--	142386641(+)	`CGACCA/GATTGT`	2	--	us2k¹		5		NS EA	510
rs11574688^1,2	C,H	--	142387233(+)	`TTCAAC/GTTCAA`	3	--	us2k¹		5		NA NS EA	424
rs10241727^1,2	C,H	--	142387265(+)	`CCCGTC/TTCCGT`	3	--	us2k¹		6		NS EA NA	414
rs11981631^1,2	C,H,	--	142387581(+)	`TCTGAG/CGGGAG`	3	--	us2k¹ ut5¹ ese³ trp³		5		NS EA WA	522
rs4647282^1,2	H	--	142387895(+)	`CGCTCC/GGAGCC`	3	--	us2k¹ int¹		5		NS EA	568
rs4647283^1,2	C,	--	142388310(+)	`CGGTCA/GTTCCA`	3	--	us2k¹ int¹		1		NS	166
rs4647284^1,2	C,F,H,	--	142388508(+)	`GTTCAC/TGTTTA`	3	--	us2k¹ int¹		12		NS EA NA WA	1512
rs10246434^1,2	C,	--	142388690(+)	`AGGGGC/G/TGTCCC`	3	--	us2k¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CASP2 (142985308 - 143004789 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CASP2: --
Human Gene Mutation Database (HGMD): CASP2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CASP2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CASP2 for disorders           About GeneDecksing

OMIM gene information: 600639    OMIM disorders: --

20/49 diseases for CASP2 (see all 49):    About MalaCards

temporal lobe epilepsy huntington's disease alzheimer's disease saethre-chotzen syndrome

bladder transitional cell papilloma non-hodgkin lymphoma gastrointestinal stromal tumor primary effusion lymphoma

lymphoblastic leukemia acute promyelocytic leukemia hodgkin's lymphoma acute lymphoblastic leukemia

chronic lymphocytic leukemia lymphocytic leukemia papilloma leukemia

retinal ischemia colon carcinoma ovarian carcinoma ischemia

10/25 Novoseek disease relationships for CASP2 gene (see all 25) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	37.4	22	11408858 (3), 19935698 (2), 15492260 (2), 17195089 (2) (see all 13)
cancer	37.4	8	16172118 (1), 18375382 (1), 19293795 (1), 20208132 (1) (see all 6)
necrosis	36.9	14	11408858 (3), 10713730 (1), 18425362 (1), 18064041 (1) (see all 9)
colon carcinoma	34.5	1	9671409 (1)
adenocarcinoma lung	32.6	4	18375382 (1), 15941563 (1)
leukemia	32.1	3	15827335 (1), 10913000 (1), 16545898 (1)
pancreatic carcinoma	24.6	1	16446371 (1)
lymphoblastic leukemia acute	19	5	10632337 (2), 11426520 (1), 16740775 (1)
melanoma	17.6	7	16569656 (3), 17308071 (2), 20187765 (2)
leukaemia lymphocytic	9.31	1	9766499 (1)

Human Genome Epidemiology (HuGE) Navigator: CASP2 (13 documents)

Export disorders for CASP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CASP2 gene, integrated from 9 sources (see all 429):
(articles sorted by number of sources associating them with CASP2)

Utopia: connect your pdf to the dynamic
world of online information

Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. (PubMed id 16652156)^{1, 2, 9} Vakifahmetoglu H.... Zhivotovsky B. (2006)
Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. (PubMed id 12920126)^{1, 2, 9} Schweizer A.... Grutter M.G. (2003)
The PIDDosome, a protein complex implicated in activation of caspase- 2 in response to genotoxic stress. (PubMed id 15073321)^{1, 2, 9} Tinel A. and Tschopp J. (2004)
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. (PubMed id 8087842)^{1, 2, 9} Wang L.... Yuan J. (1994)
Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms. (PubMed id 7789948)^{1, 3, 9} Kumar S....Hughes T.P. (1995)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade. (PubMed id 11156409)^{1, 2} Droin N.... Bertrand R. (2000)
Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and Ich-1, involved in cellular apoptosis. (PubMed id 8780721)^{1, 3} Tiso N....Danieli G.A. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 835	HGNC: 1503	AceView: CASP2	Ensembl:ENSG00000106144	euGenes: HUgn835
ECgene: CASP2	H-InvDB: CASP2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CASP2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CASP2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/casp2/

Intellectual Property for CASP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CASP2 gene:
Search GeneIP for patents involving CASP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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Advanced Cell Diagnostics
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