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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CASP2 Gene

protein-coding   GIFtS: 70
GCID: GC07P142985

Caspase 2, Apoptosis-Related Cysteine Peptidase

(Previous names: neural precursor cell expressed, developmentally down-regulated...)
(Previous symbol: NEDD2)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Caspase 2, Apoptosis-Related Cysteine Peptidase1 2     EC 3.4.22.553 8
NEDD21 2 3 5     Neural Precursor Cell Expressed, Developmentally Down-Regulated 21
ICH12 3 5     Protein Phosphatase 11
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 22 3     Regulatory Subunit 571
Protease ICH-12 3     PPP1R572
CASP-22 3     caspase-22
NEDD-22 3     Protein Phosphatase 1, Regulatory Subunit 572

External Ids:    HGNC: 15031   Entrez Gene: 8352   Ensembl: ENSG000001061447   OMIM: 6006395   UniProtKB: P425753   

Export aliases for CASP2 gene to outside databases

Previous GC identifers: GC07P141311 GC07P142379 GC07P142456 GC07P142502 GC07P142695 GC07P137322


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CASP2 Gene:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular
apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in
stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased
expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease,
Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple
isoforms have been observed for this gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for CASP2 Gene: 
CASP2 (caspase 2, apoptosis-related cysteine peptidase) is a protein-coding gene. Diseases associated with CASP2 include temporal lobe epilepsy, and bladder transitional cell papilloma, and among its related super-pathways are TNFR1 Pathway and Apoptosis and survival Caspase cascade. GO annotations related to this gene include cysteine-type endopeptidase activity and enzyme binding. An important paralog of this gene is CASP16.

UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by
either activating some proteins required for cell death or inactivating proteins necessary for cell survival

summary for CASP2 Gene:
Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of
apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and
effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with,
upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector
caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the
executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase
Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors
such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For
example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form
part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by
inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of
many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory
disease.

Gene Wiki entry for CASP2 (Caspase 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007914.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CASP2 gene promoter:
         SRF   TBP   AML1a   SRF (504 AA)   Meis-1b   E47   TFIID   Meis-1a   ZIC2/Zic2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CASP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CASP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34-q35   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34-q35

CASP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CASP2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P142985:  view genomic region     (about GC identifiers)

Start:
142,985,308 bp from pter      End:
143,004,789 bp from pter
Size:
19,482 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 142,387,424-142,406,906     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575 (See protein sequence)
Recommended Name: Caspase-2 precursor  
Size: 452 amino acids; 50685 Da
Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit
and a p12 subunit. Interacts with LRDD
Sequence caution: Sequence=AAA58959.1; Type=Erroneous initiation; Sequence=AAO25653.1; Type=Erroneous initiation;
Sequence=AAP22346.1; Type=Erroneous initiation; Sequence=AAP22349.1; Type=Erroneous initiation;
Sequence=BAD92877.1; Type=Erroneous initiation;
6/9 PDB 3D structures from and Proteopedia for CASP2 (see all 9):
1PYO (3D)        2P2C (3D)        3R5J (3D)        3R6G (3D)        3R6L (3D)        3R7B (3D)    
Secondary accessions: A8K5F9 D3DXD6 E9PDN0 P42576 Q59F21 Q7KZL6 Q86UJ3 Q9BUP7 Q9BZK9 Q9BZL0
Alternative splicing: 3 isoforms:  P42575-1   P42575-2   P42575-3   (May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death)

Explore the universe of human proteins at neXtProt for CASP2: NX_P42575

Explore proteomics data for CASP2 at MOPED 

Post-translational modifications:

  • UniProtKB: The mature protease can process its own propeptide, but not that of other caspases
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P42575

  • 4/6 DME Specific Peptides for CASP2 (P42575) (see all 6)
     GSFSQNVE  LNLLPKRGP  SPGCEESDA  DGKLLQLQE 

    CASP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CASP2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001215.1  NP_116764.2  NP_116765.2  

    ENSEMBL proteins: 
     ENSP00000312664   ENSP00000376656   ENSP00000340030  
    Reactome Protein details: P42575
    Human Recombinant Protein Products for CASP2: 
    EMD Millipore Purified and/or Recombinant CASP2 Protein
    R&D Systems Recombinant & Natural Proteins for CASP2 (Caspase-2)
    Enzo Life Sciences proteins for CASP2
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CASP2
    GenScript Custom Purified and Recombinant Proteins Services for CASP2
    Novus Biologicals CASP2 Proteins
    Novus Biologicals CASP2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CASP2 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    CASP2 for ontologies           About GeneDecksing



    CASP2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CASP2
    R&D Systems Antibodies for CASP2 (Caspase-2)
    Cell Signaling Technology (CST) Antibodies for CASP2 
    OriGene Antibodies for CASP2
    OriGene Custom Antibody Services for CASP2
    GenScript Custom Superior Antibodies Services for CASP2
    Novus Biologicals CASP2 Antibodies
    Abcam antibodies for CASP2
    Cloud-Clone Corp. Antibodies for CASP2 
    ThermoFisher Antibodies for CASP2
    LSBio Antibodies in human, mouse, rat for CASP2 

    Assay Products for CASP2: 
    EMD Millipore Kits and Assays for the Analysis of CASP2
    OriGene Custom Assay Services for CASP2
    R&D Systems Kinase Activity Assays & Reagents for CASP2 (Caspase-2)
    GenScript CASP2-Activity-based Protease Assay for Compound Screening
    Enzo Life Sciences assays for CASP2
    Cloud-Clone Corp. ELISAs for CASP2 
    Cloud-Clone Corp. CLIAs for CASP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CASP: Caspases
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    IUPHAR Guide to PHARMACOLOGY protein family classification: Caspase 2 
    Caspases

    5/9 InterPro protein domains (see all 9):
     IPR001309 Pept_C14_ICE_p20
     IPR011029 DEATH-like_dom
     IPR017350 Caspase_IL-1_beta
     IPR002138 Pept_C14_p10
     IPR015917 Pept_C14_p45_core

    Graphical View of Domain Structure for InterPro Entry P42575

    ProtoNet protein and cluster: P42575

    3 Blocks protein domains:
    IPB001309 Caspase-1
    IPB001315 CARD interaction domain
    IPB002398 Interleukin-1B converting enzyme signature


    UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575
    Similarity: Belongs to the peptidase C14A family
    Similarity: Contains 1 CARD domain


    CASP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CASP2_HUMAN, P42575
    Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by
    either activating some proteins required for cell death or inactivating proteins necessary for cell survival
    Catalytic activity: Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic
    activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp- -

         Genatlas biochemistry entry for CASP2:
    caspase 2,cysteine containing aspartate-specific protease,stored in the mitochondrial intermembrane space and
    released into cytosol after appropriate apoptotic stimuli,expressed in neural precursor cell,developmentally
    down-regulated,promoting apoptosis,Nedd 2 murine homolog,mammalian interleukin 1 beta convertase

         Enzyme Number (IUBMB): EC 3.4.22.551 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IDA10980123
    GO:0005515protein binding IPI11076957
    GO:0008233peptidase activity ----
    GO:0008234cysteine-type peptidase activity ----
    GO:0019899enzyme binding ISS11076957
         
    CASP2 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for CASP2:
     Cell division defect  Decreased POU5F1-GFP protein e  Increased 8N DNA content  Increased cell death HMECs cel 
     Increased cell death in breast 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Casp2):
     cellular  endocrine/exocrine gland  hematopoietic system  immune system  mortality/aging 
     nervous system  reproductive system 

    CASP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CASP2: Casp2tm1Yuan Casp2tm1Vaux

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CASP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CASP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CASP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CASP2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CASP2
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate CASP2 (see all 38):
    hsa-miR-194* hsa-miR-1914* hsa-miR-106a hsa-miR-449a hsa-miR-342-3p hsa-miR-93 hsa-miR-28-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidCASP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CASP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CASP2
    Sirion Biotech Customized adenovirus for overexpression of CASP2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CASP2 (see all 11)
    OriGene ORF clones in mouse, rat for CASP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CASP2 (NM_032982)
    Sino Biological Human cDNA Clone for CASP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASP2
    Sirion Biotech Customized lentivirus for stable overexpression of CASP2 
                         Customized lentivirus expression plasmids for stable overexpression of CASP2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CASP2
    Search LifeMap BioReagents cell lines for CASP2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CASP2 About   (see all 27)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    TNFR1 Pathway0.56
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    TNF Signaling0.55
    Apoptosis through Death Receptors0.42
    Apoptosis and survival TNFR1 signaling pathway0.52
    Fas Signaling0.35
    GITR Pathway0.46
    Apoptosis Modulation by HSP700.35
    2Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    Caspase cascade in apoptosis0.42
    Apoptosis and survival Caspase cascade0.44
    3p53 Pathway
    p53 Signaling0.38
    p53 Pathway0.38
    4Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Apoptotic TNF-family pathways0.35
    Apoptosis Signaling Pathways0.35
    5Cell death signalling via NRAGE, NRIF and NADE
    Cell death signalling via NRAGE, NRIF and NADE0.74
    p75 NTR receptor-mediated signalling0.73

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for CASP2
        Apoptosis and survival TNFR1 signaling pathway
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Apoptosis and survival Apoptotic TNF-family pathways

    1 R&D Systems Pathway for CASP2
        Apoptosis Signaling Pathways

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CASP2 (see all 17)
        Caspase Cascade
    14-3-3 Induced Apoptosis
    DHA Signaling
    Endothelin-1 Signaling Pathway
    TNF-Induced Apoptosis Implicating Sphingolipids

    1 Cell Signaling Technology (CST) Pathway for CASP2
        Apoptosis and Autophagy

    4 GeneGo (Thomson Reuters) Pathways for CASP2
        Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Apoptosis and survival TNFR1 signaling pathway

    5/8 BioSystems Pathways for CASP2 (see all 8)
        MAPK signaling pathway
    Apoptosis
    Apoptosis Modulation and Signaling
    Parkinsons Disease Pathway
    TNF-alpha/NF-kB Signaling Pathway

    3 Sino Biological Pathways for CASP2 
        EGFR Signaling Pathway
    p53 Pathway
    Death Receptor Signaling

    5/9        Reactome Pathways for CASP2 (see all 9)
        Cell death signalling via NRAGE, NRIF and NADE
    NADE modulates death signalling
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    p75 NTR receptor-mediated signalling
    Signal Transduction



    CASP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CASP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/55 Interacting proteins for CASP2 (P425751, 2, 3 ENSP000003126644) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRADDP785601, 2, 3, ENSP000003276474EBI-520342,EBI-520375 MINT-17424 I2D: score=6 STRING: ENSP00000327647
    PRKDCP785271, 3, ENSP000003134204EBI-520342,EBI-352053 I2D: score=1 STRING: ENSP00000313420
    EEF1A1P681042, 3MINT-8250645 I2D: score=2 
    RAI1Q7Z5J42, 3MINT-8250656 I2D: score=2 
    GRB2P629932, 3, ENSP000003390074MINT-8256547 I2D: score=2 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001554luteolysis IEA--
    GO:0003407neural retina development IEA--
    GO:0006508proteolysis IEA--
    GO:0006915apoptotic process NAS11156409
    GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP--

    CASP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CASP2 for compounds           About GeneDecksing

    EMD Millipore small molecules for CASP2:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for CASP2

    Compounds for CASP2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AZ 10417808Selective non-peptide caspase-3 inhibitor[331645-84-2]
    Z-DQMD-FMKCaspase-3 inhibitor--
    CisplatinPotent pro-apoptotic anticancer agent; activates caspase-3[15663-27-1]
    Z-DEVD-FMK Cell-permeable, irreversible caspase-3 inhibitor --
    Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor [187389-52-2]

    1 IUPHAR Ligand for CASP2 (Caspase 2)    About this table 
    LigandTypeActionAffinityPubmed IDs
    Z-VDVAD-FMK
    InhibitorInhibition10912804

    10/61 Novoseek inferred chemical compound relationships for CASP2 gene (see all 61)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1,4-anthraquinone 73.1 1 15037204 (1)
    wp631 65.1 2 16319532 (1), 16735036 (1)
    phenoxodiol 61.2 1 16388521 (1)
    phosphatidylserine 55.1 5 16215683 (1), 16243317 (1), 9345052 (1), 17893514 (1) (see all 5)
    etoposide 53.4 23 15817479 (4), 12065594 (4), 19549763 (2), 19488905 (2) (see all 9)
    adpribose 52.3 1 9128256 (1)
    rottlerin 51.1 7 18413747 (7)
    polyadenosine diphosphate ribose 49.2 2 12351403 (1), 17599497 (1)
    z-vad-fmk 46.9 1 16545898 (1)
    ceramide 45.7 12 15817479 (4), 11368523 (2), 17666435 (2), 15262979 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about CASP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CASP2 gene (3 alternative transcripts): 
    NM_001224.4  NM_032982.3  NM_032983.3  

    Unigene Cluster for CASP2:

    Caspase 2, apoptosis-related cysteine peptidase
    Hs.368982  [show with all ESTs]
    Unigene Representative Sequence: NM_032982
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310447(uc003wco.3 uc003wcp.3 uc011kta.2 uc003wcq.3 uc011ktb.2)
    ENST00000392925 ENST00000350623 ENST00000493642 ENST00000481483 ENST00000472067


    miRNA
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    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate CASP2 (see all 38):
    hsa-miR-194* hsa-miR-1914* hsa-miR-106a hsa-miR-449a hsa-miR-342-3p hsa-miR-93 hsa-miR-28-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidCASP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CASP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASP2
    Clone
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    OriGene clones in human, mouse for CASP2 (see all 11)
    OriGene ORF clones in mouse, rat for CASP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CASP2 (NM_032982)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASP2
    Sirion Biotech Customized lentivirus for stable overexpression of CASP2 
                         Customized lentivirus expression plasmids for stable overexpression of CASP2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CASP2
    OriGene qSTAR qPCR primer pairs in human, mouse for CASP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CASP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CASP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASP2

    Additional mRNA sequence: 

    AF314174.1 AK096245.1 AK291274.1 AK303265.1 BC002427.2 BT007240.1 CR541748.1 U13021.1 

    13 DOTS entries:

    DT.454941  DT.121119586  DT.75168038  DT.216001  DT.87000033  DT.86839154  DT.100835221  DT.98083042 
    DT.100790400  DT.121119475  DT.121119587  DT.95195341  DT.97823615 

    24/186 AceView cDNA sequences (see all 186):

    BQ016282 AI380767 CD672270 CA421223 AA774648 BM664681 CR591430 BI869374 
    NM_032982 AW505293 AW502916 BF057560 BF475907 AA243486 BM818044 BQ421870 
    NM_032984 NM_001224 NM_032983 BQ938085 AA481283 BQ925010 BX282023 AA233693 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CASP2 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ·
    SP1:                                                              -                             -                             -     -                           
    SP2:                                -                             -                             -                       -     -     -                           
    SP3:                                                  -     -     -     -                       -                       -     -     -                           
    SP4:                                -                 -     -     -     -                       -                                                               
    SP5:              -     -     -     -                             -                                                                                             

    ExUns: 17c · 17d · 17e
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for CASP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CASP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCCCTAGCA
    CASP2 Expression
    About this image


    See CASP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CASP2

    SOURCE GeneReport for Unigene cluster: Hs.368982

    UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575
    Tissue specificity: Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and
    brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart,
    brain, liver and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including CASP2 (see all 7): 
              Cancer PathwayFinder in human mouse rat
              p53 Signaling Pathway in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CASP2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Casp21 , 5 caspase 21, 5 86.28(n)1
    89.6(a)1
      6 (20.54 cM)5
    123661  NM_007610.11  NP_031636.11 
     422649855 
    chicken
    (Gallus gallus)
    Aves CASP21 caspase 2, apoptosis-related cysteine peptidase 66.98(n)
    71.56(a)
      395857  NM_001167701.1  NP_001161173.1 
    lizard
    (Anolis carolinensis)
    Reptilia CASP26
    Caspase
    67(a)
    1 ↔ 1
    GL343391.1(930536-959214)
    African clawed frog
    (Xenopus laevis)
    Amphibia xCaspase-22 caspase-2 76.4(n)    AB038168.1 
    zebrafish
    (Danio rerio)
    Actinopterygii casp22 caspase 2, apoptosis-related cysteine protease 71.78(n)   373118  AI815376.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nc6
    Nedd2-like caspase
    18(a)
    1 → many
    3L(9961579-9964102)
    worm
    (Caenorhabditis elegans)
    Secernentea ced-31 Protein CED-3 46.45(n)
    36.39(a)
      178272  NM_070137.4  NP_502538.1 


    ENSEMBL Gene Tree for CASP2 (if available)
    TreeFam Gene Tree for CASP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CASP2 gene
    CASP162  CASP62  CASP82  CASP122  CASP92  CASP72  CASP32  CASP142  
    CASP12  CASP52  CASP102  CASP42  
    6 SIMAP similar genes for CASP2 using alignment to 2 protein entries:     CASP2_HUMAN (see all proteins):
    CRADD    DKFZp586A181    CASP9    CASP14    CASP7    CASP3

    CASP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/526 SNPs in CASP2 are shown (see all 526)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112878481,2
    C--142990208(+) TTTTG-/TTTTTT 3 -- int1 trp30--------
    rs112974261,2
    C--142993827(+) GAACC-/AAAAAA 3 -- int1 trp30--------
    rs46473121,2
    C,F--142994447(+) GTATT-/TCTTTT 3 -- int1 trp31Minor allele frequency- T:0.01NS 174
    rs46473241,2
    C,F--142998114(+) gttaaA/-gaagt 3 -- int13Minor allele frequency- -:0.01NS NA 160
    rs2012115741,2
    C--146347291(+) CATCGG/TAAGAG 2 -- us2k10--------
    rs1855026011,2
    --146347321(+) CCTCCC/TTCTCT 2 -- us2k10--------
    rs1897681681,2
    C--146347373(+) TTGGCA/GTCAGC 2 -- us2k10--------
    rs2018469791,2
    --146347426(+) CAGAC-/AAAAAA 2 -- us2k10--------
    rs1404772711,2
    C--146347459(+) ATGGAA/GGCCAC 2 -- us2k10--------
    rs2012173421,2
    C--146347638(+) CATCCA/GGAGGG 2 -- us2k11Minor allele frequency- G:0.00EU 1323

    HapMap Linkage Disequilibrium report for CASP2 (142985308 - 143004789 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CASP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831169CNV Loss17160897
    nsv5984CNV Loss18451855


    Human Gene Mutation Database (HGMD): CASP2
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CASP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600639    OMIM disorders: --

    20/47 diseases for CASP2 (see all 47):    About MalaCards
    temporal lobe epilepsy    bladder transitional cell papilloma    primary effusion lymphoma    polyploidy
    retinal ischemia    brain cancer    huntington's disease    saethre-chotzen syndrome
    alzheimer's disease    myocardial infarction    papilloma    gastrointestinal stromal tumor
    acute promyelocytic leukemia    testicular cancer    ischemia    esophageal adenocarcinoma
    lymphoblastic leukemia    astrocytoma    lung adenocarcinoma    non-hodgkin lymphoma


    CASP2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/25 Novoseek inferred disease relationships for CASP2 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 37.4 22 11408858 (3), 19935698 (2), 15492260 (2), 17195089 (2) (see all 13)
    cancer 37.4 8 16172118 (1), 18375382 (1), 19293795 (1), 20208132 (1) (see all 6)
    necrosis 36.9 14 11408858 (3), 10713730 (1), 18425362 (1), 18064041 (1) (see all 9)
    colon carcinoma 34.5 1 9671409 (1)
    adenocarcinoma lung 32.6 4 18375382 (1), 15941563 (1)
    leukemia 32.1 3 15827335 (1), 10913000 (1), 16545898 (1)
    pancreatic carcinoma 24.6 1 16446371 (1)
    lymphoblastic leukemia acute 19 5 10632337 (2), 11426520 (1), 16740775 (1)
    melanoma 17.6 7 16569656 (3), 17308071 (2), 20187765 (2)
    leukaemia lymphocytic 9.31 1 9766499 (1)

    Genetic Association Database (GAD): CASP2
    Human Genome Epidemiology (HuGE) Navigator: CASP2 (13 documents)

    Export disorders for CASP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CASP2 gene, integrated from 9 sources (see all 435):
    (articles sorted by number of sources associating them with CASP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. (PubMed id 16652156)1, 2, 9 Vakifahmetoglu H.... Zhivotovsky B. (2006)
    2. Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. (PubMed id 12920126)1, 2, 9 Schweizer A.... Grutter M.G. (2003)
    3. The PIDDosome, a protein complex implicated in activation of caspase- 2 in response to genotoxic stress. (PubMed id 15073321)1, 2, 9 Tinel A. and Tschopp J. (2004)
    4. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. (PubMed id 8087842)1, 2, 9 Wang L.... Yuan J. (1994)
    5. Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms. (PubMed id 7789948)1, 3, 9 Kumar S....Hughes T.P. (1995)
    6. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    7. Germline variation in apoptosis pathway genes and ris k of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (2010)
    8. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    9. Mutational analysis of caspase genes in prostate carc inomas. (PubMed id 20402676)1, 4 Kim M.S....Lee S.H. (2010)
    10. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 835 HGNC: 1503 AceView: CASP2 Ensembl:ENSG00000106144 euGenes: HUgn835
    ECgene: CASP2 H-InvDB: CASP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CASP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CASP2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/casp2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CASP2 gene:
    Search GeneIP for patents involving CASP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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