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CASP2 Gene

protein-coding   GIFtS: 71
GCID: GC07P142985

Caspase 2, Apoptosis-Related Cysteine Peptidase

(Previous names: neural precursor cell expressed, developmentally down-regulated...)
(Previous symbol: NEDD2)
  See CASP2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Caspase 2, Apoptosis-Related Cysteine Peptidase1 2     EC 3.4.22.553 8
NEDD21 2 3 5     Neural Precursor Cell Expressed, Developmentally Down-Regulated 21
ICH12 3 5     Protein Phosphatase 11
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 22 3     Regulatory Subunit 571
Protease ICH-12 3     PPP1R572
CASP-22 3     caspase-22
NEDD-22 3     Protein Phosphatase 1, Regulatory Subunit 572

External Ids:    HGNC: 15031   Entrez Gene: 8352   Ensembl: ENSG000001061447   OMIM: 6006395   UniProtKB: P425753   

Export aliases for CASP2 gene to outside databases

Previous GC identifers: GC07P141311 GC07P142379 GC07P142456 GC07P142502 GC07P142695 GC07P137322


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CASP2 Gene:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular
apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in
stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased
expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease,
Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple
isoforms have been observed for this gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for CASP2 Gene:
CASP2 (caspase 2, apoptosis-related cysteine peptidase) is a protein-coding gene. Diseases associated with CASP2 include temporal lobe epilepsy, and retinal ischemia. GO annotations related to this gene include cysteine-type endopeptidase activity and enzyme binding. An important paralog of this gene is CASP16.

UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by
either activating some proteins required for cell death or inactivating proteins necessary for cell survival

summary for CASP2 Gene:
Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of
apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and
effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with,
upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector
caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the
executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase
Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors
such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For
example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form
part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by
inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of
many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory
disease.

Gene Wiki entry for CASP2 (Caspase 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CASP2 gene promoter:
         SRF   TBP   AML1a   SRF (504 AA)   Meis-1b   E47   TFIID   Meis-1a   ZIC2/Zic2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CASP2 promoter sequence
   Search Chromatin IP Primers for CASP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CASP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34-q35   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34-q35

CASP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CASP2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P142985:  view genomic region     (about GC identifiers)

Start:
142,985,308 bp from pter      End:
143,004,789 bp from pter
Size:
19,482 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 142,387,424-142,406,906     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575 (See protein sequence)
Recommended Name: Caspase-2 precursor  
Size: 452 amino acids; 50685 Da
Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit
and a p12 subunit. Interacts with LRDD
Sequence caution: Sequence=AAA58959.1; Type=Erroneous initiation; Sequence=AAO25653.1; Type=Erroneous initiation;
Sequence=AAP22346.1; Type=Erroneous initiation; Sequence=AAP22349.1; Type=Erroneous initiation;
Sequence=BAD92877.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for CASP2 (see all 9):
1PYO (3D)        2P2C (3D)        3R5J (3D)        3R6G (3D)        3R6L (3D)        3R7B (3D)    
Secondary accessions: A8K5F9 D3DXD6 E9PDN0 P42576 Q59F21 Q7KZL6 Q86UJ3 Q9BUP7 Q9BZK9 Q9BZL0
Alternative splicing: 3 isoforms:  P42575-1   P42575-2   P42575-3   (May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death)

Explore the universe of human proteins at neXtProt for CASP2: NX_P42575

Explore proteomics data for CASP2 at MOPED

Post-translational modifications: 

  • The mature protease can process its own propeptide, but not that of other caspases1
  • Ubiquitination2 at Lys15, Lys214
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CASP2 (P42575) (see all 6)
     GSFSQNVE  LNLLPKRGP  SPGCEESDA  DGKLLQLQE 


    See CASP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001215.1  NP_116764.2  NP_116765.2  

    ENSEMBL proteins: 
     ENSP00000312664   ENSP00000376656   ENSP00000340030  
    Reactome Protein details: P42575

    CASP2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CASP2 Protein
    R&D Systems Recombinant & Natural Proteins for CASP2 (Caspase-2)
    Enzo Life Sciences proteins for CASP2
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CASP2
    GenScript Custom Purified and Recombinant Proteins Services for CASP2
    Novus Biologicals CASP2 Proteins
    Novus Biologicals CASP2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CASP2

     
    Search eBioscience for Proteins for CASP2 

     
    antibodies-online proteins for CASP2 (15 products) 

     
    antibodies-online peptides for CASP2

    CASP2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CASP2
    R&D Systems Antibodies for CASP2 (Caspase-2)
    Cell Signaling Technology (CST) Antibodies for CASP2 
    OriGene Antibodies for CASP2
    OriGene Custom Antibody Services for CASP2
    Novus Biologicals CASP2 Antibodies
    Abcam antibodies for CASP2
    Cloud-Clone Corp. Antibodies for CASP2
    ThermoFisher Antibodies for CASP2
    antibodies-online antibodies for CASP2 (149 products) 

    CASP2 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of CASP2
    OriGene Custom Assay Services for CASP2
    R&D Systems Enzyme Activity Assays & Reagents for CASP2 (Caspase-2)
    GenScript CASP2-Activity-based Protease?src=genec Assay for Compound Screening
    Enzo Life Sciences assays for CASP2
    Cloud-Clone Corp. ELISAs for CASP2
    Cloud-Clone Corp. CLIAs for CASP2
    Search eBioscience for ELISAs for CASP2 
    antibodies-online kits for CASP2 (30 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CASP: Caspases
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    IUPHAR Guide to PHARMACOLOGY protein family classification: Caspase 2
    Caspases

    Selected InterPro protein domains (see all 8):
     IPR001309 Pept_C14_ICE_p20
     IPR011029 DEATH-like_dom
     IPR017350 Caspase_IL-1_beta
     IPR002138 Pept_C14_p10
     IPR015917 Pept_C14A_p45_core

    Graphical View of Domain Structure for InterPro Entry P42575

    ProtoNet protein and cluster: P42575

    3 Blocks protein domains:
    IPB001309 Caspase-1
    IPB001315 CARD interaction domain
    IPB002398 Interleukin-1B converting enzyme signature


    UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575
    Similarity: Belongs to the peptidase C14A family
    Similarity: Contains 1 CARD domain


    Find genes that share domains with CASP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CASP2_HUMAN, P42575
    Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by
    either activating some proteins required for cell death or inactivating proteins necessary for cell survival
    Catalytic activity: Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic
    activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp- -

         Genatlas biochemistry entry for CASP2:
    caspase 2,cysteine containing aspartate-specific protease,stored in the mitochondrial intermembrane space and
    released into cytosol after appropriate apoptotic stimuli,expressed in neural precursor cell,developmentally
    down-regulated,promoting apoptosis,Nedd 2 murine homolog,mammalian interleukin 1 beta convertase

         Enzyme Number (IUBMB): EC 3.4.22.551 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IDA10980123
    GO:0005515protein binding IPI11076957
    GO:0008234cysteine-type peptidase activity ----
    GO:0019899enzyme binding ISS11076957
    GO:0019904protein domain specific binding IPI9044836
         
    Find genes that share ontologies with CASP2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for CASP2:
     Cell division defect  Decreased POU5F1-GFP protein e  Increased 8N DNA content  Increased cell death HMECs cel 
     Increased cell death in breast 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Casp2):
     cellular  endocrine/exocrine gland  hematopoietic system  immune system  mortality/aging 
     nervous system  reproductive system 

    Find genes that share phenotypes with CASP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CASP2: Casp2tm1Yuan Casp2tm1Vaux

       genOway: Develop your customized and physiologically relevant rodent model for CASP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CASP2:
    hsa-mir-421 (MIRT039414), hsa-mir-130b-3p (MIRT044168), hsa-mir-93-3p (MIRT038813)

    Block miRNA regulation of human, mouse, rat CASP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CASP2 (see all 38):
    hsa-miR-194* hsa-miR-1914* hsa-miR-106a hsa-miR-449a hsa-miR-342-3p hsa-miR-93 hsa-miR-28-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidCASP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CASP2
    Predesigned siRNA for gene silencing in human, mouse, rat CASP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CASP2

    Clone
    Products:
         
    OriGene clones in human, mouse for CASP2 (see all 11)
    OriGene ORF clones in mouse, rat for CASP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CASP2 (NM_032982)
    Sino Biological Human cDNA Clone for CASP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CASP2
    Addgene plasmids for CASP2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CASP2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CASP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion3
    nucleus2
    cytoskeleton1
    endoplasmic reticulum1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus TAS18309324
    GO:0005737cytoplasm IBA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CASP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CASP2 About   (see all 25)  
    See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    TNFR1 Pathway0.56
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    TNF Signaling0.55
    Apoptosis through Death Receptors0.42
    Apoptosis and survival TNFR1 signaling pathway0.52
    Fas Signaling0.35
    GITR Pathway0.46
    Apoptosis Modulation by HSP700.35
    2Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    Caspase cascade in apoptosis0.42
    Apoptosis and survival FAS signaling cascades0.44
    3p53 Signaling
    p53 Signaling0.38
    p53 Pathway0.38
    4Apoptosis Signaling Pathways
    Apoptosis and survival Apoptotic TNF family pathways0.35
    Apoptosis Signaling Pathways0.35
    5p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    NADE modulates death signalling0.00
    Cell death signalling via NRAGE, NRIF and NADE0.74


    Find genes that share SuperPaths with CASP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CASP2
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CASP2 (see all 17)
        Caspase Cascade
    14-3-3 Induced Apoptosis
    DHA Signaling
    Endothelin-1 Signaling Pathway
    TNF-Induced Apoptosis Implicating Sphingolipids

    1 Cell Signaling Technology (CST) Pathway for CASP2
        Apoptosis and Autophagy

    4 GeneGo (Thomson Reuters) Pathways for CASP2
        Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Apoptosis and survival TNFR1 signaling pathway

    Selected BioSystems Pathways for CASP2 (see all 8)
        MAPK signaling pathway
    Apoptosis
    Apoptosis Modulation and Signaling
    Parkinsons Disease Pathway
    TNF-alpha/NF-kB Signaling Pathway

    3 Sino Biological Pathways for CASP2
        EGFR Signaling Pathway
    p53 Pathway
    Death Receptor Signaling

    2 Reactome Pathways for CASP2
        NOD1/2 Signaling Pathway
    NADE modulates death signalling


        Pathway & Disease-focused RT2 Profiler PCR Arrays including CASP2 (see all 7): 
              Cancer PathwayFinder in human mouse rat
              p53 Signaling Pathway in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CASP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CASP2 (P425751, 2, 3 ENSP000003126644) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRADDP785601, 2, 3, ENSP000003276474EBI-520342,EBI-520375 MINT-17424 I2D: score=6 STRING: ENSP00000327647
    PRKDCP785271, 3, ENSP000003134204EBI-520342,EBI-352053 I2D: score=1 STRING: ENSP00000313420
    EEF1A1P681042, 3MINT-8250645 I2D: score=2 
    RAI1Q7Z5J42, 3MINT-8250656 I2D: score=2 
    GRB2P629932, 3, ENSP000003390074MINT-8256547 I2D: score=2 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001554luteolysis IEA--
    GO:0003407neural retina development IEA--
    GO:0006508proteolysis ----
    GO:0006915apoptotic process NAS11156409
    GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP--

    Find genes that share ontologies with CASP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CASP2
    Selected ApexBio Compounds for CASP2 (see all 12)     About this table
    CompoundAction CAS #
    Apoptosis InhibitorCell-permeable caspase-3 inhibitor[54135-60-3]
    Caspase-3/7 Inhibitor ICell-permeable and irreversible inhibitor of caspase-3 and -7[220509-74-0]
    CisplatinChemotherapy agent, induces apoptosis[15663-27-1]
    PAC-1Procaspase-activating compound, activates procaspase-3 and converts it to caspase-3[315183-21-2]
    Q-VD-OphCell-permeable, irreversible pan-caspase inhibitor[1135695-98-5]
    VX-765 Novel Caspase-1 inhibitor[273404-37-8]
    Z-DEVD-FMKCell-permeable, and irreversible caspase-3 inhibitor[210344-95-9]
    Z-DQMD-FMKCell-permeable caspase-3 inhibitor--
    Z-FA-FMKEffector caspases 2, 3, 5, and 7--
    Z-VAD-FMKCell-permeable, irreversible pan-caspase inhibitor[187389-52-2]

    Compounds for CASP2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AZ 10417808Selective non-peptide caspase-3 inhibitor[331645-84-2]
    Z-DQMD-FMKCaspase-3 inhibitor--
    CisplatinPotent pro-apoptotic anticancer agent; activates caspase-3[15663-27-1]
    Z-DEVD-FMK Cell-permeable, irreversible caspase-3 inhibitor --
    Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor [187389-52-2]

    1 IUPHAR Ligand for CASP2 (Caspase 2)    About this table
    LigandTypeActionAffinityPubmed IDs
    Z-VDVAD-FMK
    InhibitorInhibition10912804

    Selected Novoseek inferred chemical compound relationships for CASP2 gene (see all 61)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1,4-anthraquinone 73.1 1 15037204 (1)
    wp631 65.1 2 16319532 (1), 16735036 (1)
    phenoxodiol 61.2 1 16388521 (1)
    phosphatidylserine 55.1 5 16215683 (1), 16243317 (1), 9345052 (1), 17893514 (1) (see all 5)
    etoposide 53.4 23 15817479 (4), 12065594 (4), 19549763 (2), 19488905 (2) (see all 9)
    adpribose 52.3 1 9128256 (1)
    rottlerin 51.1 7 18413747 (7)
    polyadenosine diphosphate ribose 49.2 2 12351403 (1), 17599497 (1)
    z-vad-fmk 46.9 1 16545898 (1)
    ceramide 45.7 12 15817479 (4), 11368523 (2), 17666435 (2), 15262979 (1) (see all 6)



    Find genes that share compounds with CASP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CASP2 gene (3 alternative transcripts): 
    NM_001224.4  NM_032982.3  NM_032983.3  

    Unigene Cluster for CASP2:

    Caspase 2, apoptosis-related cysteine peptidase
    Hs.368982  [show with all ESTs]
    Unigene Representative Sequence: NM_032982
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310447(uc003wco.3 uc003wcp.3 uc011kta.2 uc003wcq.3 uc011ktb.2)
    ENST00000392925 ENST00000350623 ENST00000493642 ENST00000481483 ENST00000472067

    miRNA
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    Block miRNA regulation of human, mouse, rat CASP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CASP2 (see all 38):
    hsa-miR-194* hsa-miR-1914* hsa-miR-106a hsa-miR-449a hsa-miR-342-3p hsa-miR-93 hsa-miR-28-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidCASP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CASP2
    Clone
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    OriGene ORF clones in mouse, rat for CASP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CASP2 (NM_032982)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CASP2
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      QuantiFast Probe-based Assays in human, mouse, rat CASP2

    Additional mRNA sequence: 

    AF314174.1 AK096245.1 AK291274.1 AK303265.1 BC002427.2 BT007240.1 CR541748.1 U13021.1 

    13 DOTS entries:

    DT.454941  DT.121119586  DT.75168038  DT.216001  DT.87000033  DT.86839154  DT.100835221  DT.98083042 
    DT.100790400  DT.121119475  DT.121119587  DT.95195341  DT.97823615 

    Selected AceView cDNA sequences (see all 186):

    CD671883 BQ925010 NM_032982 AA233657 BM802814 AW505293 AW768251 BF475907 
    AA779091 AW574992 AW951422 BU733273 AA233693 CA421223 BM818044 BM741098 
    NM_032984 AA774648 BI869374 CD672270 U13021 AA233233 AA243486 BQ421870 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CASP2 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ·
    SP1:                                                              -                             -                             -     -                           
    SP2:                                -                             -                             -                       -     -     -                           
    SP3:                                                  -     -     -     -                       -                       -     -     -                           
    SP4:                                -                 -     -     -     -                       -                                                               
    SP5:              -     -     -     -                             -                                                                                             

    ExUns: 17c · 17d · 17e
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for CASP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CASP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCCCTAGCA
    CASP2 Expression
    About this image

    CASP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CASP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368982

    UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575
    Tissue specificity: Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and
    brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart,
    brain, liver and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CASP2 (see all 7): 
              Cancer PathwayFinder in human mouse rat
              p53 Signaling Pathway in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CASP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Casp21 , 5 caspase 21, 5 86.28(n)1
    89.6(a)1
      6 (20.54 cM)5
    123661  NM_007610.11  NP_031636.11 
     422649855 
    chicken
    (Gallus gallus)
    Aves CASP21 caspase 2, apoptosis-related cysteine peptidase 67.06(n)
    71.56(a)
      395857  NM_001167701.1  NP_001161173.1 
    lizard
    (Anolis carolinensis)
    Reptilia CASP26
    caspase 2, apoptosis-related cysteine peptidase
    67(a)
    1 ↔ 1
    GL343391.1(930536-959214)
    African clawed frog
    (Xenopus laevis)
    Amphibia xCaspase-22 caspase-2 76.4(n)    AB038168.1 
    zebrafish
    (Danio rerio)
    Actinopterygii casp22 caspase 2, apoptosis-related cysteine protease 71.78(n)   373118  AI815376.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nc6
    Dredd6
    Death related ced-3/Nedd2-like protein
    19(a)
    16(a)
    many ↔ many
    many ↔ many
    3L(9961579-9964102)
    X(527553-529760)


    ENSEMBL Gene Tree for CASP2 (if available)
    TreeFam Gene Tree for CASP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CASP2 gene
    CASP162  CASP62  CASP82  CASP122  CASP92  CASP72  CASP32  CASP142  
    CASP12  CASP52  CASP102  CASP42  
    6 SIMAP similar genes for CASP2 using alignment to 2 protein entries:     CASP2_HUMAN (see all proteins):
    CRADD    DKFZp586A181    CASP9    CASP14    CASP7    CASP3

    Find genes that share paralogs with CASP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CASP2 (see all 526)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112878481,2
    C--142990208(+) TTTTG-/TTTTTT 3 -- int1 trp30--------
    rs112974261,2
    C--142993827(+) GAACC-/AAAAAA 3 -- int1 trp30--------
    rs46473121,2
    C,F--142994447(+) GTATT-/TCTTTT 3 -- int1 trp31Minor allele frequency- T:0.01NS 174
    rs46473241,2
    C,F--142998114(+) gttaaA/-gaagt 3 -- int13Minor allele frequency- -:0.01NS NA 160
    rs2012115741,2
    C--146347291(+) CATCGG/TAAGAG 2 -- us2k10--------
    rs1855026011,2
    --146347321(+) CCTCCC/TTCTCT 2 -- us2k10--------
    rs1897681681,2
    C--146347373(+) TTGGCA/GTCAGC 2 -- us2k10--------
    rs2018469791,2
    --146347426(+) CAGAC-/AAAAAA 2 -- us2k10--------
    rs1404772711,2
    C--146347459(+) ATGGAA/GGCCAC 2 -- us2k10--------
    rs2012173421,2
    C--146347638(+) CATCCA/GGAGGG 2 -- us2k11Minor allele frequency- G:0.00EU 1323

    HapMap Linkage Disequilibrium report for CASP2 (142985308 - 143004789 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CASP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831169CNV Loss17160897
    nsv5984CNV Loss18451855

    Human Gene Mutation Database (HGMD): CASP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CASP2
    DNA2.0 Custom Variant and Variant Library Synthesis for CASP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600639    OMIM disorders: --

    6 diseases for CASP2:    
    About MalaCards
    temporal lobe epilepsy    retinal ischemia    polyploidy    primary effusion lymphoma
    saethre-chotzen syndrome    myocardial infarction


    Find genes that share disorders with CASP2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CASP2 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 37.4 22 11408858 (3), 19935698 (2), 15492260 (2), 17195089 (2) (see all 13)
    cancer 37.4 8 16172118 (1), 18375382 (1), 19293795 (1), 20208132 (1) (see all 6)
    necrosis 36.9 14 11408858 (3), 10713730 (1), 18425362 (1), 18064041 (1) (see all 9)
    colon carcinoma 34.5 1 9671409 (1)
    adenocarcinoma lung 32.6 4 18375382 (1), 15941563 (1)
    leukemia 32.1 3 15827335 (1), 10913000 (1), 16545898 (1)
    pancreatic carcinoma 24.6 1 16446371 (1)
    lymphoblastic leukemia acute 19 5 10632337 (2), 11426520 (1), 16740775 (1)
    melanoma 17.6 7 16569656 (3), 17308071 (2), 20187765 (2)
    leukaemia lymphocytic 9.31 1 9766499 (1)

    Genetic Association Database (GAD): CASP2
    Human Genome Epidemiology (HuGE) Navigator: CASP2 (13 documents)

    Export disorders for CASP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CASP2 gene, integrated from 10 sources (see all 439):
    (articles sorted by number of sources associating them with CASP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. (PubMed id 16652156)1, 2, 9 Vakifahmetoglu H.... Zhivotovsky B. (Oncogene 2006)
    2. Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. (PubMed id 12920126)1, 2, 9 Schweizer A.... Grutter M.G. (J. Biol. Chem. 2003)
    3. The PIDDosome, a protein complex implicated in activation of caspase- 2 in response to genotoxic stress. (PubMed id 15073321)1, 2, 9 Tinel A. and Tschopp J. (Science 2004)
    4. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. (PubMed id 8087842)1, 2, 9 Wang L.... Yuan J. (Cell 1994)
    5. Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms. (PubMed id 7789948)1, 3, 9 Kumar S....Hughes T.P. (Hum. Genet. 1995)
    6. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    7. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (amp 2010)
    8. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    9. Mutational analysis of caspase genes in prostate carcinomas. (PubMed id 20402676)1, 4 Kim M.S....Lee S.H. (APMIS 2010)
    10. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 835 HGNC: 1503 AceView: CASP2 Ensembl:ENSG00000106144 euGenes: HUgn835
    ECgene: CASP2 H-InvDB: CASP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CASP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CASP2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/casp2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CASP2 gene:
    Search GeneIP for patents involving CASP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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