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CASP2 Gene

protein-coding GIFtS: 68

GC07P142695

caspase 2, apoptosis-related cysteine peptidase
(Previous names: neural precursor cell expressed, developmentally down-regulated 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: NEDD2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CASP-2 ^², ³
EC 3.4.22.55 ^³
ICH-1L ^²
ICH-1L/1S ^²
ICH1 ^¹, ², ³, ⁵
NEDD-2 ^³
NEDD2 ^², ³, ⁵

Descriptions
ICH-1 protease ^², ³
NEDD2 apoptosis regulatory ^²
Neural precursor cell expressed developmentally down-regulated protein 2 ^³
caspase 2 ^²
caspase 2, apoptosis-related cysteine peptidase ^²
neural precursor cell expressed, developmentally down-regulated 2 ^¹, ²

External Ids
HGNC: 1503¹
Entrez Gene: 835²
UniProtKB: P42575³
Ensembl: ENSG00000106144⁷

Search outside databases for aliases for CASP2 gene

Previous GC identifers: GC07P141311 GC07P142379 GC07P142456 GC07P142502

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CASP2:

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase)

family. Sequential activation of caspases plays a central role in the execution-phase of cell

apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved

aspartic residues to produce two subunits, large and small, that dimerize to form the active

enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli.

Alternative splicing of this gene results in multiple transcript variants that encode different

isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575

Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Might

function by either activating some proteins required for cell death or inactivating proteins

necessary for cell survival

Gene Wiki entry for CASP2 (Caspase_2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CASP2 gene

Entrez Gene cytogenetic band: 7q34-q35 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q34-q35

CASP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P142695: (about GC identifiers)

Start:	142,695,524 bp from pter
End:	142,714,907 bp from pter
Size:	19,384 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 142,387,518-142,406,902

RefSeq DNA sequence:

NC_000007.12 NT_007914.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575 (See protein sequence)

Recommended Name: Caspase-2 precursor

Size: 452 amino acids; 50685 Da

Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed

by a p18 subunit and a p12 subunit. Interacts with LRDD

PDB structure from and Proteopedia :

1PYO (3D)

2P2C (3D)

Secondary accessions: P42576 Q59F21 Q7KZL6 Q86UJ3 Q9BUP7 Q9BZK9

Alternative splicing: 2 isoforms: P42575-1 P42575-2 (Isoforms differ in the N- and C-termini)

Post-translational modifications:

The mature protease can process its own propeptide, but not that of other caspases¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_116764.2 NP_116765.2

ENSEMBL proteins:

ENSP00000312664 ENSP00000376656 ENSP00000376654 ENSP00000340030

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant CASP2 Protein
	Sigma-Aldrich Proteins for CASP2
	R&D Systems Recombinant & Natural Proteins for CASP2 (Caspase-2)
	Enzo Life Sciences proteins for CASP2
	Recombinant Proteins from Abcam (active Caspase 2, Caspase 2)
	Human Recombinant Proteins from Abnova (CASP2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	IEA	--

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Antibodies for CASP2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CASP2
	Sigma-Aldrich Antibody Arrays and Antibodies for CASP2
	R&D Systems Antibodies for CASP2 (Caspase-2)
	Cell Signaling Technology (CST) Antibodies for CASP2 (Caspase-2)
	Antibodies from Abcam (active Caspase 2, Caspase 2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CASP2)
	Novus Biologicals Antibodies for CASP2

Assays for CASP2:

	Invitrogen Assays for CASP2
	Millipore Kits and Assays for the Analysis of CASP2
	R&D Systems Peptides & Peptide-based Assays for CASP2 (Caspase-2) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P42575

ProtoNet protein and cluster: P42575

3 Blocks protein families:

IPB001309 Caspase-1

IPB001315 CARD interaction domain

IPB002398 Interleukin-1B converting enzyme signature

UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575

Similarity: Belongs to the peptidase C14A family

Similarity: Contains 1 CARD domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CASP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CASP2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001224

Applied Biosystems Silencer® siRNAs for CASP2

Sigma-Aldrich siRNA and siRNA Panels for CASP2

Sigma-Aldrich shRNA Panels and shRNA for CASP2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CASP2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_032982
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_032982
untagged cDNA clones in CMV expression vector (see all 4): NM_001224

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_032982

UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575

Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Might

function by either activating some proteins required for cell death or inactivating proteins

necessary for cell survival

Catalytic activity: Strict requirement for an Asp residue at P1, with 316-asp being essential for

proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp- -

Enzyme Number (IUBMB): EC 3.4.22.55

Genatlas biochemistry entry for CASP2:

caspase 2,cysteine containing aspartate-specific protease,stored in the mitochondrial intermembrane

space and released into cytosol after appropriate apoptotic stimuli,expressed in neural precursor

cell,developmentally down-regulated,promoting apoptosis,Nedd 2 murine homolog,mammalian

interleukin 1 beta convertase

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Casp2):

cellular	endocrine/exocrine gland	hematopoietic system	immune system	lethality-prenatal/perinatal
nervous system	reproductive system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004197	cysteine-type endopeptidase activity	NAS	11156409
GO:0008233	peptidase activity	IEA	--
GO:0019899	enzyme binding	ISS	11076957
GO:0042802	identical protein binding	IPI	11156409

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5 Sigma-Aldrich "Your Favorite Gene" Pathways for CASP2 (Your Favorite Gene powered by Ingenuity)

Huntington's Disease Signaling
Endothelin-1 Signaling
Lysine Degradation
Apoptosis Signaling
Death Receptor Signaling

GeneDecks CASP2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CASP2

5/77 Interacting proteins for CASP2 (ENSP00000312664³ P42575^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 77 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CRADD	P78560¹^,²	STRING (score=.999) EBI-520342, EBI-520375 MINT-17424 EBI-520342, EBI-520375 MINT-17424
CASP2	P42575¹	EBI-520357, EBI-520342
CRADD	P78560¹^,²	STRING (score=.999) EBI-520342, EBI-520375 MINT-17424 EBI-520342, EBI-520375 MINT-17424
FADD	ENSP00000301838³	STRING (score=.993)
TNFRSF1A	ENSP00000162749³	STRING (score=.993)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	TAS	8087842
GO:0042981	regulation of apoptosis	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CASP2

Browse Small Molecules at Sigma-Aldrich

Compounds for CASP2 available from Tocris Bioscience

Compound	Action	CAS number
Ac-DEVD-AFC	Fluorogenic caspase substrate	[201608-14-2]
Z-VDVAD-FMK	Irreversible caspase-2 inhibitor
Ac-LEHD-AFC	Fluorogenic caspase substrate	[210345-03-2]
Z-VAD-FMK	Cell-permeable, irreversible caspase inhibitor

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10/29 Novoseek chemical compound relationships for CASP2 gene (see all 29 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
1,4-anthraquinone	74.42	1	15037204 (1)
wp631	65.86	2	16319532 (1), 16735036 (1)
phenoxodiol	62.54	1	16388521 (1)
polyadenosine diphosphate ribose	51.45	2	12351403 (1), 17599497 (1)
ceramide	45.24	12	15817479 (4), 11368523 (2), 17666435 (2), 15262979 (1) (see all 6)
sp 600125	37.40	1	14716300 (1)
tetrapeptide	37.09	1	10791974 (1)
mevalonate	19.80	3	14678744 (3)
okadaic acid	10.07	3	15817479 (1), 16682503 (1)
oxygen	8.85	2	16545898 (1), 16446371 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CASP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CASP2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001224

Sigma-Aldrich siRNA and siRNA Panels for CASP2

Sigma-Aldrich shRNA Panels and shRNA for CASP2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_032982 NM_032983

REFSEQ mRNAs for CASP2 gene (2 alternative transcripts):

NM_032982.2 NM_032983.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_032982 NM_032983

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_032982
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_032982
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001224

Additional cDNA sequence:

AF314174.1 AK096245.1 AK291274.1 AK303265.1 AK303391.1 BC002427.2 BT007240.1 CR541748.1

CR591430.1 U13021.1

13 DOTS entries:

DT.454941 DT.121119586 DT.75168038 DT.216001 DT.87000033 DT.86839154 DT.100835221 DT.98083042

DT.100790400 DT.121119475 DT.121119587 DT.95195341 DT.97823615

24/186 AceView cDNA sequences (see all 186 ):

NM_032982 AI097182 NM_032983 CD672270 AA774648 BQ421870 AA243486 CR541748

CA421223 BM818044 BM741098 AA810033 BQ938085 AW951422 AU131719 BX282023

AA481283 CD672269 NM_001224 AA298416 U13021 BQ925010 AW502916 BF475907

highest scoring ESTs for CASP2:

N23013 U13021 AA009914 AA215319 AA233157 AA233233 AA233657 AA233693 AA243424 AA243486

Unigene Cluster for CASP2:

Caspase 2, apoptosis-related cysteine peptidase

Hs.368982 [show with all ESTs]

Unigene Representative Sequence: NM_032982

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CASP2 (see all 10 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11a	·	11b	·	11c	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17a	·	17b	·
SP1:																					-										-										-		-
SP2:											-										-										-								-		-		-
SP3:																	-		-		-		-								-								-		-		-
SP4:											-						-		-		-		-								-
SP5:					-		-		-		-										-

ExUns:	17c	·	17d	·	17e
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for CASP2

4 Ensembl transcripts including schematic representations:

ENST00000310447 ENST00000392925 ENST00000392923 ENST00000350623

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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CASP2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CASP2

¹ / ² / ³

19 probe-sets matching CASP2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1239_s_at²^{, 3}	U95-A	1	1.00	1.00	0.87	0.64	U13021	1.00	0.87	0.94	1
34449_at²^{, 3}	U133-A	1	1.00	1.00	0.66	0.92	U13022	0.80	0.83	0.82	1
1240_at²^{, 3}	U95-A	1	1.00	1.00	0.42	0.91	U13022	0.80	0.83	0.82	1
48571_at²^{, 3}	U95-B	1	1.00	1.00	0.88	1.53	N23013	1.00	1.00	1.00	1
34448_s_at²^{, 3}	U95-A	3	1.00	0.96	0.51	0.46	U13021	1.00	0.87	0.94	1
226032_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AU153405	0.60	1.00	0.82	1
209811_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC002427	0.80	0.83	0.82	1
208050_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001224	0.40	1.00	0.76	1
34449_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U13022	0.80	0.83	0.82	1
211140_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF314174	0.80	0.83	0.82	1
209812_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U13021	1.00	0.87	0.94	1
226036_x_at²^{, 3}	U133-B	129	1.00	0.62	--	--	BE139156	0.40	1.00	0.76	1
226032_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209811_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208050_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
34449_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211140_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209812_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226036_x_at²	U133Plus2	129	1.00	0.62	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTCCCTAGCA

SOURCE GeneReport for Unigene cluster: Hs.368982
Expression variation in blood from EXPOLDB for CASP2
UniProtKB/Swiss-Prot: CASP2_HUMAN, P42575
Tissue specificity: Expressed at higher levels in the embryonic lung, liver and kidney than in the
heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and
pancreas than in the heart, brain, liver and skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CASP2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CASP2¹	--	caspase 2, apoptosis-related cysteine peptidase	88.5(n) 89.82(a)	482737 XM_843508.1 XP_848601.1
chimpanzee (Pan troglodytes)	CASP2¹	--	caspase 2, apoptosis-related cysteine peptidase	99.78(n) 100(a)	463804 XM_519448.2 XP_519448.2
cow (Bos taurus)	CASP2¹	--	caspase 2, apoptosis-related cysteine peptidase	84.06(n) 87.82(a)	531419 XM_864029.2 XP_869122.1
rat (Rattus norvegicus)	Casp2¹	--	caspase 2	86.36(n) 89.6(a)	64314 NM_022522.2 NP_071967.2
mouse (Mus musculus)	Casp2^{1, 5}	6 (20.50 cM)⁵	caspase 2^{1, 5}	86.28(n)¹ 89.6(a)¹	12366¹ NM_007610.1¹ NP_031636.1¹ AK042072⁵ AK133829⁵ (see all 23)

About this table Species with no ortholog for CASP2

ENSEMBL Gene Tree for CASP2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CASP2 gene

CASP14²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/119 NCBI SNPs in CASP2 are shown (see all 119 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 60)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4647342^1,2	C,F,H	142713454(+)	`CCCTGT/ATCTTT`	2	--	ut3¹		8	NS EU EA WA NA	736
	rs4647339^1,2	C,F,H	142712293(+)	`GTCACC/TTCCCC`	2	--	ut3¹ ese³		8	NS EU EA WA NA	730
	rs4647297^1,2	C,F,H	142701483(+)	`GTCCTG/CTCTGC`	2	L/V	mis¹ int¹		19	NS NA EU EA WA	1860
	rs13438745^1,2	C,H	142715038(+)	`CCCTTC/TTTATT`	2	--	ng3¹		4	EU EA WA	416
	rs4647338^1,2	F,H	142712248(+)	`TGTGCC/GGCCAC`	2	R/G	mis¹ ut3¹ ese³		5	NS EU EA WA	588
--	rs4647340^1,2	C,F	142712604(+)	`TTCCCC/TATATT`	2	--	ut3¹		4	NS NA	316
	rs3212152^1,2	H	142712322(+)	`AAGCCA/CCTGGA`	2	--	ut3¹ ese³		5	NA EU EA WA	450
	rs3212151^1,2	H	142712224(+)	`AGATGT/GCTGAA`	2	A/S	mis¹ ut3¹		5	NA EU EA WA	452
	rs4647298^1,2	H	142701501(+)	`TGAAGC/GCTTGC`	2	P/A A/G	mis¹		5	NS EU EA WA	578
--	rs4647341^1,2	F	142713112(+)	`AGAAAC/TGTCCA`	2	--	ut3¹ ese³		1	NS	176

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HapMap Linkage Disequilibrium images for CASP2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600639

10/25 Novoseek disease relationships for CASP2 gene (see all 25 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	37.77	14	11408858 (3), 10713730 (1), 18425362 (1), 18064041 (1) (see all 9)
tumors	37.19	20	11408858 (3), 15492260 (2), 17195089 (2), 18425362 (1) (see all 12)
adenocarcinoma lung	35.38	4	18375382 (1), 15941563 (1)
cancer	34.94	7	16172118 (1), 18375382 (1), 19293795 (1), 12920126 (1) (see all 5)
leukemia	31.36	3	15827335 (1), 10913000 (1), 16545898 (1)
pancreatic carcinoma	26.59	1	16446371 (1)
colon carcinoma	24.03	1	9671409 (1)
lymphoblastic leukemia acute	21.24	5	10632337 (2), 11426520 (1), 16740775 (1)
prostate cancer	11.78	4	16849572 (1), 18615564 (1), 17110788 (1), 17262078 (1)
melanoma	11.46	5	16569656 (3), 17308071 (2)

About this table

Human Genome Epidemiology Navigator: CASP2 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/353 PubMed articles for CASP2 gene (see all 353 ):

Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. (PubMed id 16652156)^{1, 3, 4} Vakifahmetoglu H.... Zhivotovsky B. (2006)
Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. (PubMed id 12920126)^{1, 3, 4} Schweizer A.... Grutter M.G. (2003)
The PIDDosome, a protein complex implicated in activation of caspase- 2 in response to genotoxic stress. (PubMed id 15073321)^{1, 3, 4} Tinel A. and Tschopp J. (2004)
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. (PubMed id 8087842)^{1, 3, 4} Wang L.... Yuan J. (1994)
Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms. (PubMed id 7789948)^{1, 2, 3} Kumar S....Hughes T.P. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{3, 4} Hillier L.W.... Wilson R.K. (2003)
Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade. (PubMed id 11156409)^{3, 4} Droin N.... Bertrand R. (2000)
Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and Ich-1, involved in cellular apoptosis. (PubMed id 8780721)^{2, 3} Tiso N....Danieli G.A. (1996)
The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. (PubMed id 8654923)^{3, 4} Xue D.... Horvitz H.R. (1996)

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Entrez Gene: 835	HGNC: 1503	AceView: CASP2	Ensembl:ENSG00000106144	euGenes: HUgn835
ECgene: CASP2	H-InvDB: CASP2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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Name	Description
ATLAS Chromosomes in Cancer entry for CASP2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/casp2/

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CASP2 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for CASP2

Summaries
for CASP2

Genomic Location
for CASP2

Proteins
for CASP2

Protein Domains/
Families
for CASP2

Gene Function
for CASP2

Pathways & Interactions
for CASP2

Drugs & Compounds
for CASP2

Transcripts
for CASP2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CASP2 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor CASP2

Summariesfor CASP2

Genomic Locationfor CASP2

Proteinsfor CASP2

Protein Domains/Familiesfor CASP2

Gene Functionfor CASP2

Pathways & Interactionsfor CASP2

Drugs & Compoundsfor CASP2

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Expression for CASP2

Orthologsfor CASP2

Paralogsfor CASP2

SNPs/Variantsfor CASP2

Disorders & Mutationsfor CASP2

Medical Newsfor CASP2

Publicationsfor CASP2

Search for CASP2

Genome Databases showing CASP2

Other Databases showing CASP2

Specialized Databases showing CASP2

Licensable Technologiesfor CASP2

Servicesfor CASP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CASP2

Summaries
for CASP2

Genomic Location
for CASP2

Proteins
for CASP2

Protein Domains/
Families
for CASP2

Gene Function
for CASP2

Pathways & Interactions
for CASP2

Drugs & Compounds
for CASP2

Transcripts
for CASP2

Expression
for CASP2

Orthologs
for CASP2

Paralogs
for CASP2

SNPs/Variants
for CASP2

Disorders & Mutations
for CASP2

Medical News
for CASP2

Publications
for CASP2

Licensable Technologies
for CASP2

Services
for CASP2