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Aliases for CASP2 Gene

Aliases for CASP2 Gene

  • Caspase 2, Apoptosis-Related Cysteine Peptidase 2 3
  • NEDD2 3 4 6
  • ICH1 3 4 6
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 2 3 4
  • Protease ICH-1 3 4
  • EC 3.4.22.55 4 63
  • CASP-2 3 4
  • NEDD-2 3 4
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 2 2
  • Protein Phosphatase 1, Regulatory Subunit 57 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 57 2
  • Caspase-2 3
  • PPP1R57 3

External Ids for CASP2 Gene

Previous Symbols for CASP2 Gene

  • NEDD2

Summaries for CASP2 Gene

Entrez Gene Summary for CASP2 Gene

  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for CASP2 Gene

CASP2 (Caspase 2, Apoptosis-Related Cysteine Peptidase) is a Protein Coding gene. Diseases associated with CASP2 include temporal lobe epilepsy and retinal ischemia. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include enzyme binding and cysteine-type endopeptidase activity. An important paralog of this gene is CASP1.

UniProtKB/Swiss-Prot for CASP2 Gene

  • Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival

Tocris Summary for CASP2 Gene

  • Caspases (short for cysteinyl aspartate proteases) are involved in the signal transduction pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of many disorders including stroke, Alzheimers disease, myocardial infarction, cancer, and inflammatory disease.

Gene Wiki entry for CASP2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP2 Gene

Genomics for CASP2 Gene

Genomic Location for CASP2 Gene

Start:
143,288,215 bp from pter
End:
143,307,696 bp from pter
Size:
19,482 bases
Orientation:
Plus strand

Genomic View for CASP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CASP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP2 Gene

Regulatory Elements for CASP2 Gene

Proteins for CASP2 Gene

  • Protein details for CASP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42575-CASP2_HUMAN
    Recommended name:
    Caspase-2
    Protein Accession:
    P42575
    Secondary Accessions:
    • A8K5F9
    • D3DXD6
    • E9PDN0
    • P42576
    • Q59F21
    • Q7KZL6
    • Q86UJ3
    • Q9BUP7
    • Q9BZK9
    • Q9BZL0

    Protein attributes for CASP2 Gene

    Size:
    452 amino acids
    Molecular mass:
    50685 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD. Interacts with NOL3 (via CARD domain); inhibits CASP2 activity in a phosphorylation-dependent manner.
    SequenceCaution:
    • Sequence=AAA58959.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAO25653.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP22346.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP22349.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92877.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CASP2 Gene

    Alternative splice isoforms for CASP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CASP2 Gene

Proteomics data for CASP2 Gene at MOPED

Selected DME Specific Peptides for CASP2 Gene

Post-translational modifications for CASP2 Gene

  • The mature protease can process its own propeptide, but not that of other caspases.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys15 and Lys214

Other Protein References for CASP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CASP2 Gene

Gene Families for CASP2 Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
  • CASP :Caspases
IUPHAR :

Suggested Antigen Peptide Sequences for CASP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P42575

UniProtKB/Swiss-Prot:

CASP2_HUMAN
Domain:
  • Contains 1 CARD domain.:
    • P42575
Family:
  • Belongs to the peptidase C14A family.:
    • P42575
genes like me logo Genes that share domains with CASP2: view

Function for CASP2 Gene

Molecular function for CASP2 Gene

GENATLAS Biochemistry: caspase 2,cysteine containing aspartate-specific protease,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,expressed in neural precursor cell,developmentally down-regulated,promoting apoptosis,Nedd 2 murine homolog,mammalian interleukin 1 beta convertase
UniProtKB/Swiss-Prot CatalyticActivity: Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp- -
UniProtKB/Swiss-Prot Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival

Enzyme Numbers (IUBMB) for CASP2 Gene

Gene Ontology (GO) - Molecular Function for CASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IDA 10980123
GO:0005515 protein binding IPI 11076957
GO:0008234 cysteine-type peptidase activity --
GO:0019899 enzyme binding ISS 11076957
GO:0019904 protein domain specific binding IPI 9044836
genes like me logo Genes that share ontologies with CASP2: view
genes like me logo Genes that share phenotypes with CASP2: view

Animal Models for CASP2 Gene

MGI Knock Outs for CASP2:

miRNA for CASP2 Gene

miRTarBase miRNAs that target CASP2

No data available for Transcription Factor Targeting and HOMER Transcription for CASP2 Gene

Localization for CASP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CASP2 Gene COMPARTMENTS Subcellular localization image for CASP2 gene
Compartment Confidence
cytosol 4
mitochondrion 3
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 18309324
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CASP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CASP2 Gene

Pathways for CASP2 Gene

genes like me logo Genes that share pathways with CASP2: view

Gene Ontology (GO) - Biological Process for CASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001554 luteolysis IEA --
GO:0003407 neural retina development IEA --
GO:0006508 proteolysis --
GO:0006915 apoptotic process NAS 11156409
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IBA --
genes like me logo Genes that share ontologies with CASP2: view

Compounds for CASP2 Gene

(12) ApexBio Compounds for CASP2 Gene

Compound Action Cas Number
Apoptosis Inhibitor Cell-permeable caspase-3 inhibitor [54135-60-3]
Caspase-3/7 Inhibitor I Cell-permeable and irreversible inhibitor of caspase-3 and -7 [220509-74-0]
Cisplatin Chemotherapy agent, induces apoptosis [15663-27-1]
PAC-1 Procaspase-activating compound, activates procaspase-3 and converts it to caspase-3 [315183-21-2]
Q-VD-Oph Cell-permeable, irreversible pan-caspase inhibitor [1135695-98-5]
VX-765 Novel Caspase-1 inhibitor [273404-37-8]
Z-DEVD-FMK Cell-permeable, and irreversible caspase-3 inhibitor [210344-95-9]
Z-DQMD-FMK Cell-permeable caspase-3 inhibitor
Z-FA-FMK An inhibitor of cysteine proteases, such as cathepsin B.
Z-VAD-FMK Cell-permeable, irreversible pan-caspase inhibitor [187389-52-2]
Z-VDVAD-FMK Cell-permeable and irreversible caspase-2 inhibitor
Z-VEID-FMK Cell-permeable and irreversible caspase-6 inhibitor

(5) Tocris Compounds for CASP2 Gene

Compound Action Cas Number
AZ 10417808 Selective non-peptide caspase-3 inhibitor [331645-84-2]
Cisplatin Potent pro-apoptotic anticancer agent; activates caspase-3 [15663-27-1]
Z-DEVD-FMK Cell-permeable, irreversible caspase-3 inhibitor
Z-DQMD-FMK Caspase-3 inhibitor
Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor [187389-52-2]

(1) IUPHAR Ligand for CASP2 Gene

Ligand Type Action Affinity Pubmed IDs
Z-VDVAD-FMK Inhibitor Inhibition

(61) Novoseek inferred chemical compound relationships for CASP2 Gene

Compound -log(P) Hits PubMed IDs
1,4-anthraquinone 73.1 1
wp631 65.1 2
phenoxodiol 61.2 1
phosphatidylserine 55.1 5
etoposide 53.4 18
genes like me logo Genes that share compounds with CASP2: view

Transcripts for CASP2 Gene

Unigene Clusters for CASP2 Gene

Caspase 2, apoptosis-related cysteine peptidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CASP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ·
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: -
SP7: - -
SP8: -
SP9: - - - - - - -
SP10:

ExUns: 17c · 17d · 17e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CASP2 Gene

GeneLoc Exon Structure for
CASP2
ECgene alternative splicing isoforms for
CASP2

Expression for CASP2 Gene

mRNA expression in normal human tissues for CASP2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CASP2 Gene

SOURCE GeneReport for Unigene cluster for CASP2 Gene Hs.368982

mRNA Expression by UniProt/SwissProt for CASP2 Gene

P42575-CASP2_HUMAN
Tissue specificity: Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle
genes like me logo Genes that share expressions with CASP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CASP2 Gene

Orthologs for CASP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CASP2 35
  • 99.78 (n)
  • 100 (a)
CASP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CASP2 35
  • 84.88 (n)
  • 88.05 (a)
CASP2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CASP2 35
  • 88.89 (n)
  • 90.7 (a)
CASP2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Casp2 35
  • 86.28 (n)
  • 89.6 (a)
Casp2 16
Casp2 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CASP2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CASP2 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Casp2 35
  • 86.36 (n)
  • 89.6 (a)
chicken
(Gallus gallus)
Aves CASP2 35
  • 67.06 (n)
  • 71.56 (a)
CASP2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CASP2 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia xCaspase-2 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486813 35
  • 56.45 (n)
  • 51.19 (a)
zebrafish
(Danio rerio)
Actinopterygii casp2 35
  • 55.18 (n)
  • 52.15 (a)
casp2 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dredd 36
  • 16 (a)
ManyToMany
Nc 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
CSA.5278 36
  • 31 (a)
OneToMany
Species with no ortholog for CASP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASP2 Gene

ENSEMBL:
Gene Tree for CASP2 (if available)
TreeFam:
Gene Tree for CASP2 (if available)

Paralogs for CASP2 Gene

Selected SIMAP similar genes for CASP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CASP2: view

Variants for CASP2 Gene

Sequence variations from dbSNP and Humsavar for CASP2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs869420 -- 143,296,507(+) GCTGG(C/T)CTTGA intron-variant
rs1141773 -- 143,306,309(+) tggag(G/T)gcagt utr-variant-3-prime
rs1141775 -- 143,306,360(+) cacgc(A/C)attct utr-variant-3-prime
rs1141776 -- 143,306,368(+) tctcc(C/T)gcctc utr-variant-3-prime
rs1815163 -- 143,293,529(-) ccatc(A/C)caaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CASP2 Gene

Variant ID Type Subtype PubMed ID
nsv831169 CNV Loss 17160897
nsv5984 CNV Loss 18451855

Relevant External Links for CASP2 Gene

HapMap Linkage Disequilibrium report
CASP2
Human Gene Mutation Database (HGMD)
CASP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASP2 Gene

Disorders for CASP2 Gene

(25) Novoseek inferred disease relationships for CASP2 Gene

Disease -log(P) Hits PubMed IDs
tumors 37.4 18
cancer 37.4 6
necrosis 36.9 11
colon carcinoma 34.5 1
adenocarcinoma lung 32.6 2

Relevant External Links for CASP2

Genetic Association Database (GAD)
CASP2
Human Genome Epidemiology (HuGE) Navigator
CASP2
genes like me logo Genes that share disorders with CASP2: view

No data available for UniProtKB/Swiss-Prot for CASP2 Gene

Publications for CASP2 Gene

  1. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. (PMID: 8087842) Wang L. … Yuan J. (Cell 1994) 3 4 23
  2. Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. (PMID: 12920126) Schweizer A. … Grutter M.G. (J. Biol. Chem. 2003) 3 4 23
  3. The PIDDosome, a protein complex implicated in activation of caspase- 2 in response to genotoxic stress. (PMID: 15073321) Tinel A. … Tschopp J. (Science 2004) 3 4 23
  4. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. (PMID: 16652156) Vakifahmetoglu H. … Zhivotovsky B. (Oncogene 2006) 3 4 23
  5. Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8. (PMID: 16193064) Shin S. … Kim K. (EMBO J. 2005) 3 23

Products for CASP2 Gene

  • Addgene plasmids for CASP2

Sources for CASP2 Gene

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