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Aliases for CASP2 Gene

Aliases for CASP2 Gene

  • Caspase 2 2 3 5
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 57 2 3
  • Protease ICH-1 3 4
  • EC 4 61
  • CASP-2 3 4
  • NEDD-2 3 4
  • NEDD2 3 4
  • ICH1 3 4
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 2 2
  • Caspase 2, Apoptosis-Related Cysteine Peptidase 2
  • Caspase 2 Apoptosis-Related Cysteine Peptidase 3
  • Caspase-2 3
  • PPP1R57 3

External Ids for CASP2 Gene

Previous HGNC Symbols for CASP2 Gene

  • NEDD2

Previous GeneCards Identifiers for CASP2 Gene

  • GC07P141311
  • GC07P142379
  • GC07P142456
  • GC07P142502
  • GC07P142695
  • GC07P142985
  • GC07P137322
  • GC07P143307
  • GC07P143317
  • GC07P143325
  • GC07P143356

Summaries for CASP2 Gene

Entrez Gene Summary for CASP2 Gene

  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for CASP2 Gene

CASP2 (Caspase 2) is a Protein Coding gene. Diseases associated with CASP2 include Bladder Transitional Cell Papilloma and Retinal Ischemia. Among its related pathways are Immune System and p75 NTR receptor-mediated signalling. GO annotations related to this gene include enzyme binding and cysteine-type endopeptidase activity. An important paralog of this gene is CASP10.

UniProtKB/Swiss-Prot for CASP2 Gene

  • Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.

Tocris Summary for CASP2 Gene

  • Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.

Gene Wiki entry for CASP2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP2 Gene

Genomics for CASP2 Gene

Regulatory Elements for CASP2 Gene

Enhancers for CASP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F143248 1.1 Ensembl ENCODE 19.7 -37.9 -37915 4.2 ELF3 CBX3 MLX ARID4B RAD21 RARA YY1 MIXL1 THAP11 NR2F2 CASP2 TMEM139 LOC105375545 RN7SL535P FAM131B EPHB6 GSTK1
GH07F143258 1.5 FANTOM5 Ensembl ENCODE 13.3 -28.9 -28947 2.2 YY1 ZNF766 GATA2 CBX5 FOS SP3 JUNB NCOA1 SMARCA4 PBX2 TMEM139 LOC105375545 CASP2 RN7SL535P EPHA1 EPHA1-AS1 FAM131B HINT1P1 CLCN1 ZYX
GH07F143345 1.2 Ensembl ENCODE 11.1 +57.6 57570 1.3 ATF1 GLI4 ZNF2 ZNF48 GLIS2 KLF7 KDM4B JUNB NFIL3 ZNF610 CLCN1 HINT1P1 ZYX LOC100507507 RN7SL535P CASP2 LOC105375545 TMEM139 EPHA1 EPHA1-AS1
GH07F143244 1.1 FANTOM5 Ensembl ENCODE 11.6 -43.1 -43064 3.7 MCM7 PKNOX1 MCM3 ZNF266 KDM1A MYC FAM131B TMEM139 LOC105375545 CASP2 RN7SL535P LOC100507507 ZYX OR9A2 TAS2R39 TRPV6
GH07F143310 1 Ensembl ENCODE 11.9 +22.5 22473 0.6 CTCF ATF1 CBX3 RAD21 ZNF335 ZNF143 SMC3 ZMIZ1 ZSCAN29 CREM CASP2 LOC105375545 RN7SL535P TMEM139 GSTK1 FAM131B ZYX LOC100507507 EPHA1 EPHA1-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CASP2 on UCSC Golden Path with GeneCards custom track

Promoters for CASP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000314289 585 2001 HDGF PKNOX1 ARNT SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 KLF13

Genomic Location for CASP2 Gene

143,288,215 bp from pter
143,307,696 bp from pter
19,482 bases
Plus strand

Genomic View for CASP2 Gene

Genes around CASP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP2 Gene

Proteins for CASP2 Gene

  • Protein details for CASP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K5F9
    • D3DXD6
    • E9PDN0
    • P42576
    • Q59F21
    • Q7KZL6
    • Q86UJ3
    • Q9BUP7
    • Q9BZK9
    • Q9BZL0

    Protein attributes for CASP2 Gene

    452 amino acids
    Molecular mass:
    50685 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD. Interacts with NOL3 (via CARD domain); inhibits CASP2 activity in a phosphorylation-dependent manner.
    • Sequence=AAA58959.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAO25653.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP22346.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP22349.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92877.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CASP2 Gene

    Alternative splice isoforms for CASP2 Gene


neXtProt entry for CASP2 Gene

Selected DME Specific Peptides for CASP2 Gene


Post-translational modifications for CASP2 Gene

  • The mature protease can process its own propeptide, but not that of other caspases.
  • Ubiquitination at Lys 214
  • Modification sites at PhosphoSitePlus

Other Protein References for CASP2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CASP2 (CASP2)
  • Cloud-Clone Corp. Antibodies for CASP2

Domains & Families for CASP2 Gene

Suggested Antigen Peptide Sequences for CASP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CARD domain.
  • Belongs to the peptidase C14A family.
  • Contains 1 CARD domain.
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP2: view

Function for CASP2 Gene

Molecular function for CASP2 Gene

GENATLAS Biochemistry:
caspase 2,cysteine containing aspartate-specific protease,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,expressed in neural precursor cell,developmentally down-regulated,promoting apoptosis,Nedd 2 murine homolog,mammalian interleukin 1 beta convertase
UniProtKB/Swiss-Prot CatalyticActivity:
Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp- -.
UniProtKB/Swiss-Prot Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.

Enzyme Numbers (IUBMB) for CASP2 Gene

Gene Ontology (GO) - Molecular Function for CASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IDA 9044836
GO:0005515 protein binding IPI 9560245
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CASP2: view
genes like me logo Genes that share phenotypes with CASP2: view

Animal Models for CASP2 Gene

MGI Knock Outs for CASP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CASP2

Clone Products

  • Addgene plasmids for CASP2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CASP2 Gene

Localization for CASP2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CASP2 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 4
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 18309324
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CASP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CASP2 Gene

Pathways & Interactions for CASP2 Gene

genes like me logo Genes that share pathways with CASP2: view

SIGNOR curated interactions for CASP2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001554 luteolysis IEA --
GO:0003407 neural retina development IEA --
GO:0006508 proteolysis IEA --
GO:0006915 apoptotic process NAS 11156409
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
genes like me logo Genes that share ontologies with CASP2: view

Drugs & Compounds for CASP2 Gene

(41) Drugs for CASP2 Gene - From: ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2690
Z-VDVAD-FMK Pharma Inhibition, Inhibitor Caspase-2 inhibitor 0
Tasisulam Pharma 0
MDL 28170 Pharma Calpain and cathepsin B inhibitor, selective, Potent, selective calpain and cathepsin B inhibitor 0
PD 150606 Pharma Non-peptide calpain inhibitor, Cell permeable calpain inhibitor 0

(25) Additional Compounds for CASP2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
MG 101

(3) Tocris Compounds for CASP2 Gene

Compound Action Cas Number
MDL 28170 Potent, selective calpain and cathepsin B inhibitor 88191-84-8
MG 101 Calpain inhibitor; activates p53-dependent apoptosis 110044-82-1
PD 150606 Cell permeable calpain inhibitor 179528-45-1

(3) ApexBio Compounds for CASP2 Gene

Compound Action Cas Number
Cisplatin Inhibits DNA synthesis,chemotherapy drug 15663-27-1
Tasisulam 519055-62-0
Z-VDVAD-FMK Caspase-2 inhibitor
genes like me logo Genes that share compounds with CASP2: view

Drug Products

Transcripts for CASP2 Gene

Unigene Clusters for CASP2 Gene

Caspase 2, apoptosis-related cysteine peptidase:
Representative Sequences:

Clone Products

  • Addgene plasmids for CASP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CASP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ·
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: -
SP7: - -
SP8: -
SP9: - - - - - - -

ExUns: 17c · 17d · 17e

Relevant External Links for CASP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CASP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CASP2 Gene

Protein differential expression in normal tissues from HIPED for CASP2 Gene

This gene is overexpressed in Blymphocyte (20.8), CD8 Tcells (11.1), Peripheral blood mononuclear cells (9.2), and Fetal ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CASP2 Gene

Protein tissue co-expression partners for CASP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CASP2 Gene:


SOURCE GeneReport for Unigene cluster for CASP2 Gene:


mRNA Expression by UniProt/SwissProt for CASP2 Gene:

Tissue specificity: Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.
genes like me logo Genes that share expression patterns with CASP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CASP2 Gene

Orthologs for CASP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CASP2 34 35
  • 99.78 (n)
(Canis familiaris)
Mammalia CASP2 34 35
  • 88.89 (n)
(Rattus norvegicus)
Mammalia Casp2 34
  • 86.36 (n)
(Mus musculus)
Mammalia Casp2 34 16 35
  • 86.28 (n)
(Bos Taurus)
Mammalia CASP2 34 35
  • 84.88 (n)
(Monodelphis domestica)
Mammalia CASP2 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia CASP2 35
  • 71 (a)
(Gallus gallus)
Aves CASP2 34 35
  • 67.06 (n)
(Anolis carolinensis)
Reptilia CASP2 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486813 34
  • 56.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia xCaspase-2 34
(Danio rerio)
Actinopterygii casp2 34 35
  • 55.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nc 35
  • 19 (a)
Dredd 35
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
CSA.5278 35
  • 31 (a)
Species where no ortholog for CASP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASP2 Gene

Gene Tree for CASP2 (if available)
Gene Tree for CASP2 (if available)

Paralogs for CASP2 Gene

Paralogs for CASP2 Gene

(6) SIMAP similar genes for CASP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CASP2: view

Variants for CASP2 Gene

Sequence variations from dbSNP and Humsavar for CASP2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10241727 -- 143,288,056(+) CCCGT(C/T)TCCGT intron-variant, upstream-variant-2KB
rs10246434 -- 143,289,481(+) AGGGG(C/G/T)GTCCC intron-variant, upstream-variant-2KB
rs111333419 -- 143,291,730(+) CATGG(A/G)GTGGG intron-variant
rs111381999 -- 143,293,919(+) TGAAT(A/G)AGAAA intron-variant
rs111437190 -- 143,288,040(+) CAAAA(C/G)TCCAG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CASP2 Gene

Variant ID Type Subtype PubMed ID
nsv831169 CNV loss 17160897
nsv5984 CNV deletion 18451855

Variation tolerance for CASP2 Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.70; 57.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CASP2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASP2 Gene

Disorders for CASP2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CASP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bladder transitional cell papilloma
  • bladder papilloma
retinal ischemia
saethre-chotzen syndrome
  • saethre-chotzen syndrome with eyelid anomalies
  • dystrophinopathy
temporal lobe epilepsy
  • epilepsy, temporal lobe
- elite association - COSMIC cancer census association via MalaCards
Search CASP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CASP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CASP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CASP2 Gene

Publications for CASP2 Gene

  1. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. (PMID: 16652156) Vakifahmetoglu H. … Zhivotovsky B. (Oncogene 2006) 3 4 22 64
  2. The PIDDosome, a protein complex implicated in activation of caspase- 2 in response to genotoxic stress. (PMID: 15073321) Tinel A. … Tschopp J. (Science 2004) 3 4 22 64
  3. Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. (PMID: 12920126) Schweizer A. … Grutter M.G. (J. Biol. Chem. 2003) 3 4 22 64
  4. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. (PMID: 8087842) Wang L. … Yuan J. (Cell 1994) 3 4 22 64
  5. PIDDosome expression and the role of caspase-2 activation for chemotherapy-induced apoptosis in RCCs. (PMID: 20208132) Heikaus S. … Mahotka C. (Cell. Oncol. 2010) 3 22 64

Products for CASP2 Gene

Sources for CASP2 Gene

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