CASP16 Gene
protein-coding GIFtS: 29
GCID: GC16P003198 (predicted)
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caspase 16, apoptosis-related cysteine peptidase (putative)
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Aliases
for CASP16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Caspase 16, Apoptosis-Related Cysteine Peptidase (Putative)1 2 | | CASP14L2 3 | | Putative Caspase-14-Like Protein2 | | Putative Caspase-162 | | EC 3.4.22.-3 |
Export aliases for CASP16 gene to outside databases |
Summaries
for CASP16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CASP16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NT_010393.16 NC_018927.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CASP16
Other transcription factors
Search SABiosciences Chromatin IP Primers for CASP16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASP16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3CASP16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P003198: view genomic region
(about GC identifiers)
Start:
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3,194,220 bp from pter |
End:
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3,199,964 bp from pter |
Size:
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5,745 bases |
Orientation:
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plus strand |
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Proteins
for CASP16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CASPG_HUMAN, P0CB46 (See
protein sequence)Recommended Name: Putative caspase-16 Size: 183 amino acids; 20061 Da
Caution: Could be the product of a pseudogeneExplore the universe of human proteins at neXtProt for CASP16: NX_P0CB46
CASP16 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000400592
Human Recombinant Protein Products:
CASP16 Antibody Products:
Assay Products for CASP16: |
Protein
Domains /
Families
for CASP16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CASP16 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P0CB46ProtoNet protein and cluster: P0CB46 UniProtKB/Swiss-Prot: CASPG_HUMAN, P0CB46Similarity: Belongs to the peptidase C14A family |
Function
for CASP16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 3.4.22.-1
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP16 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0004197 | cysteine-type endopeptidase activity |
IEA | -- |
CASP16 for ontologies About GeneDecksing
|
Pathways & Interactions
for CASP16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CASP16
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
CASP16 for ontologies About GeneDecksing
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Drugs & Compounds
for CASP16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CASP16
Search CenterWatch for drugs/clinical trials and news about CASP16 / CASPG 
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Transcripts
for CASP16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
Unigene Cluster for CASP16: Caspase 16, apoptosis-related cysteine peptidase (putative) Hs.434132 [show with all ESTs]Unigene Representative Sequence: AK0969894 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000571356 ENST00000575497 ENST00000428155(uc002cuf.1) ENST00000576807
Additional cDNA sequence: AF098666.1 AK096989.1 BC111724.1 3 DOTS entries: DT.95331034 DT.99997808 DT.120688480 2 AceView cDNA sequences: AK096989 AF098666
GeneLoc Exon Structure
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Expression
for CASP16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See CASP16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CASP16
SOURCE GeneReport for Unigene cluster: Hs.434132
SABiosciences Custom PCR Arrays for CASP16
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CASP16
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CASP16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CASP16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASP16 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP16 |
Orthologs
for CASP16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of human and mouse.
Orthologs for CASP16 gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Casp165 |
predicted gene 5146 |
-- |
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17 (11.66 cM) 23551073 |
ENSEMBL Gene Tree for CASP16 (if available)
TreeFam Gene Tree for CASP16 (if available) |
Paralogs
for CASP16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CASP16 gene
- CASP62 CASP82 CASP122 CASP92 CASP72 CASP32 CASP22 CASP142
- CASP12 CASP52 CASP102 CASP42
1 SIMAP similar gene for CASP16 using alignment to 1 protein entry: CASPG_HUMAN:CASP14
CASP16 for paralogs About GeneDecksing
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Genomic Variants
for CASP16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CASP16 (3194220 - 3199964 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CASP16: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CASP16 |
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Disorders
/ Diseases
for CASP16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CASP16 for disorders About GeneDecksing
1  disease for CASP16: About MalaCardsfamilial mediterranean fever
Export disorders for CASP16 gene to outside databases
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Publications
for CASP16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CASP16 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CASP16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire. (PubMed id 18281271)1, 2, 3 Eckhart L....Tschachler E. (2008)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3. (PubMed id 9847080)1, 2 Centola M....Kastner D.L. (1998)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CASP16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CASP16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing CASP16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CASP16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
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About This Section
| Patent Information for CASP16 gene:
Search GeneIP for patents involving CASP16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CASP16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CASP16 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CASP16 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CASP16 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CASP16 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CASP16 | | Browse OriGene Myc/DDK tagged cDNA clones in CMV expression vector | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CASP16 | | OriGene Custom Protein Services for CASP16 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CASP16 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CASP16 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CASP16 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CASP16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CASP16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CASP16 |
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 |  |  |  | |
| | | | Search Tocris compounds for CASP16 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CASP16 |
|  |  |  | | | | Search ThermoFisher Antibodies for CASP16 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CASP16 |
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