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Aliases for CASP16 Gene

Aliases for CASP16 Gene

  • Caspase 16, Apoptosis-Related Cysteine Peptidase (Putative) 2 3
  • CASP14L 3 4
  • Putative Caspase-14-Like Protein 3
  • Putative Caspase-16 3
  • EC 3.4.22.- 4

External Ids for CASP16 Gene

Previous GeneCards Identifiers for CASP16 Gene

  • GC16P003198

Summaries for CASP16 Gene

GeneCards Summary for CASP16 Gene

CASP16 (Caspase 16, Apoptosis-Related Cysteine Peptidase (Putative)) is a Protein Coding gene. GO annotations related to this gene include cysteine-type endopeptidase activity. An important paralog of this gene is CASP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP16 Gene

Genomics for CASP16 Gene

Genomic Location for CASP16 Gene

3,144,015 bp from pter
3,149,963 bp from pter
5,949 bases
Plus strand

Genomic View for CASP16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CASP16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP16 Gene

No data available for Regulatory Elements for CASP16 Gene

Proteins for CASP16 Gene

  • Protein details for CASP16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative caspase-16
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CASP16 Gene

    183 amino acids
    Molecular mass:
    20061 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CASP16 Gene

Proteomics data for CASP16 Gene at MOPED

Post-translational modifications for CASP16 Gene

No Post-translational modifications

Other Protein References for CASP16 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for CASP16 Gene

Domains for CASP16 Gene

Protein Domains for CASP16 Gene

Graphical View of Domain Structure for InterPro Entry



  • P0CB46
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP16: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CASP16 Gene

Function for CASP16 Gene

Enzyme Numbers (IUBMB) for CASP16 Gene

Gene Ontology (GO) - Molecular Function for CASP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity --
GO:0008234 cysteine-type peptidase activity --
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA --
genes like me logo Genes that share ontologies with CASP16: view

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CASP16 Gene

Localization for CASP16 Gene

Gene Ontology (GO) - Cellular Components for CASP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CASP16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for CASP16 Gene

Pathways for CASP16 Gene

SuperPathways for CASP16 Gene

No Data Available

Interacting Proteins for CASP16 Gene

Gene Ontology (GO) - Biological Process for CASP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0006915 apoptotic process --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IBA --
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA --
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IBA --
genes like me logo Genes that share ontologies with CASP16: view

No data available for Pathways by source for CASP16 Gene

Transcripts for CASP16 Gene

mRNA/cDNA for CASP16 Gene

(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CASP16 Gene

Caspase 16, apoptosis-related cysteine peptidase (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CASP16 Gene

No ASD Table

Relevant External Links for CASP16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CASP16 Gene

mRNA expression in normal human tissues for CASP16 Gene

mRNA differential expression in normal tissues according to GTEx for CASP16 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (17.0), Spleen (11.2), Liver (6.2), and Adrenal Gland (5.6).

SOURCE GeneReport for Unigene cluster for CASP16 Gene Hs.434132

genes like me logo Genes that share expressions with CASP16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for CASP16 Gene

Orthologs for CASP16 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CASP16 35
  • 98.89 (n)
  • 98.33 (a)
CASP16 36
  • 61 (a)
(Bos Taurus)
Mammalia CASP16 36
  • 44 (a)
LOC788915 35
  • 79.2 (n)
  • 73.09 (a)
(Canis familiaris)
Mammalia CASP16 35
  • 80.6 (n)
  • 75.24 (a)
CASP16 36
  • 33 (a)
(Mus musculus)
Mammalia Casp16 35
  • 71.67 (n)
  • 62.86 (a)
Casp16 16
Casp16 36
  • 72 (a)
(Monodelphis domestica)
Mammalia CASP16 36
  • 22 (a)
(Ornithorhynchus anatinus)
Mammalia CASP16 36
  • 20 (a)
(Rattus norvegicus)
Mammalia LOC680728 35
  • 74.95 (n)
  • 70.66 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 15 (a)
(Danio rerio)
Actinopterygii CU467905.1 36
  • 12 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dredd 36
  • 5 (a)
Nc 36
  • 8 (a)
Species with no ortholog for CASP16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASP16 Gene

Gene Tree for CASP16 (if available)
Gene Tree for CASP16 (if available)

Paralogs for CASP16 Gene

Paralogs for CASP16 Gene

Selected SIMAP similar genes for CASP16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CASP16: view

Variants for CASP16 Gene

Sequence variations from dbSNP and Humsavar for CASP16 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs224244 -- 3,149,528(+) ccaga(A/G)cagag intron-variant
rs224245 -- 3,150,279(+) GGCCA(A/G)AATAA downstream-variant-500B
rs224249 -- 3,144,656(+) AGTGA(C/G)CTGGG intron-variant
rs551845 -- 3,148,932(+) CTGAC(A/C)TAGGC intron-variant
rs551848 -- 3,148,937(+) CTAGG(C/T)TATGT reference, synonymous-codon

Relevant External Links for CASP16 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CASP16 Gene

Disorders for CASP16 Gene

No disorders were found for CASP16 Gene.

No data available for UniProtKB/Swiss-Prot for CASP16 Gene

Publications for CASP16 Gene

  1. Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire. (PMID: 18281271) Eckhart L. … Tschachler E. (Mol. Biol. Evol. 2008) 2 3 4
  2. Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3. (PMID: 9847080) Centola M. … Kastner D.L. (Genome Res. 1998) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CASP16 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CASP16
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CASP16
    • Block miRNA regulation of CASP16 using miScript Target Protectors

    Sources for CASP16 Gene

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